Chalcogen Bonded Directly To The Hetero Ring Patents (Class 549/475)
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Publication number: 20080071084Abstract: Method for preparing compounds of the formula (III) by reacting compounds of the formula (II) with a) an alcoholate or b) an alcohol R1-OH and a base in the presence of a Cu-containing catalyst and of a ligand, where X1-5 are independently of one another either carbon or nitrogen, or in each case two adjacent X1R1, with i=1?6, linked by a formal double bond together O, S, NRH or Nrl. The ligands preferably employed are acyclic and/or cyclic oligo- and polyglycols, oligo- and polyamides or oligo- and polyamine glycols of the general formula (IV) k is an integer >0 and n is an integer >1; X and Y are independently of one another O, NH or NR1.Type: ApplicationFiled: May 30, 2007Publication date: March 20, 2008Inventors: Andreas MEUDT, Bernhard J. Rausch
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Publication number: 20080064874Abstract: Novel 2-halofuryl/thienyl-3-carboxamides of the formula (I) in which A, Hal, R, M and Z are as defined in the description, a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms, and also novel intermediates and their preparation.Type: ApplicationFiled: January 22, 2005Publication date: March 13, 2008Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFTInventors: Ralf Dunkel, Hans-Ludwig Elbe, Jorg Nico Greul, Benoit Hartmann, Peter Dahmen, Karl-Heinz Kuck, Ulrike Wachendorff-Neumann
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Publication number: 20080015366Abstract: This invention describes protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid ester and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoic acid ester for the synthesis of epothilones and epothilone derivatives and process for the production of these esters.Type: ApplicationFiled: June 5, 2004Publication date: January 17, 2008Inventors: Juergen Westermann, Johannes Platzek, Orlin Petrov
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Publication number: 20080008965Abstract: Novel ester compounds having formulae (1) to (4) wherein A1 is a polymerizable functional group having a carbon-carbon double bond, A2 is oxygen, methylene or ethylene, R1 is a monovalent hydrocarbon group, R2 is H or a monovalent hydrocarbon group, any pair of R1 and/or R2 may form an aliphatic hydrocarbon ring, R3 is a monovalent hydrocarbon group, and n is 0 to 6 are polymerizable into polymers. Resist compositions comprising the polymers as a base resin are thermally stable and sensitive to high-energy radiation, have excellent sensitivity and resolution, and lend themselves to micropatterning with electron beam or deep-UV.Type: ApplicationFiled: July 5, 2007Publication date: January 10, 2008Inventors: Masaki Ohashi, Takeshi Kinsho, Takeru Watanabe
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Patent number: 7300948Abstract: Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in the following table R1 R2 R4 R5 R8a F CF3 Me H —OH F CF3 Cl H —OH F CF3 Me H —O—CH2CO2H Cl CN Cl H —OH.Type: GrantFiled: September 29, 2005Date of Patent: November 27, 2007Assignee: Boehringer Ingelheim International GmbHInventors: Pierre Bonneau, Patrick Deroy, Alexandre Gagnon, Jeffrey O′Meara, Bruno Simoneau, Christiane Yoakim
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Patent number: 7232930Abstract: A process for preparing (S)-(?)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.Type: GrantFiled: February 28, 2005Date of Patent: June 19, 2007Assignee: Pharmacia & Upjohn CompanyInventors: Sonja Suzanne MacKey, Michael E. Matison, Haifeng Wu, Michael Paul Goble, Moses W. McMillan, Vikram Gurudath Kalthod
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Patent number: 7202274Abstract: A compound represented by the following formula (I) wherein R1 is a lower alkyl group, R2 is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or 1, which has a calpain inhibitory activity, is provided.Type: GrantFiled: March 14, 2003Date of Patent: April 10, 2007Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Masayuki Nakamura, Jun Inoue
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Patent number: 7196089Abstract: Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(?O), S(?O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(?O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III): ?wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.Type: GrantFiled: January 29, 2004Date of Patent: March 27, 2007Assignee: Asterand UK LimitedInventors: Alexander W. Oxford, Richard J. Davis, Robert A. Coleman, Kenneth L. Clark, David E. Clark, Neil V. Harris, Garry Fenton, George Hynd, Keith A. J. Stuttle, Jonathan M. Sutton, Christopher G. Newton
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Patent number: 7148363Abstract: An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or (3): In formulae (1) through (4), R1 and R2 are H or F, R3 is H, F, or an alkyl, alkenyl, fluoroalkyl or fluoroalkenyl group, R4 and R5 are H, halogen, or an alkyl, alkenyl, halogenated alkyl or halogenated alkenyl group; and X and Y are an unsubstituted or substituted hydrocarbon group, and dashed line - - - means that X and Y may be bonded together to form a cyclic structure.Type: GrantFiled: November 15, 2004Date of Patent: December 12, 2006Assignee: Tosoh CorporationInventors: Shinichi Ishikawa, Hisao Eguchi
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Patent number: 7144897Abstract: Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compounds of formula X are also disclosed.Type: GrantFiled: May 31, 2002Date of Patent: December 5, 2006Assignees: Elan Oharmaceuticals, Inc., Pharmacia & Upjohn, Co.Inventors: John Freskos, David L. Brown, Yvette M. Fobian, Larry Fang, Arthur Glenn Romero, Varghese John
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Patent number: 7132449Abstract: Compounds of general formula (I): wherein R1, R2, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.Type: GrantFiled: January 7, 2002Date of Patent: November 7, 2006Assignee: Amura Therapeutics LimitedInventor: Martin Quibell
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Patent number: 7122661Abstract: The invention concerns a method for purifying a composition containing at least a product for internal dehydration of a hydrogenated sugar. The invention is characterised in that it comprises: (a) an optional step whereby said composition is treated, whether after re-dissolving or not, with at least a discoloration means; (b) a subsequent step whereby the composition, optionally treated with discoloration means, is treated with at least ion-exchanging means; (c) a subsequent step whereby the resulting composition is treated with at least discoloration means. Said method is in particular applicable to isohexide compositions, in particular isosorbide or isomannide. The resulting compositions, which exhibit particular characteristics in terms of purity and proportion of some impurities, constitute novel products for use in chemical, pharmaceutical, cosmetology and food industries.Type: GrantFiled: December 6, 2002Date of Patent: October 17, 2006Assignee: Roquette FreresInventors: Guy Fleche, Patrick Fuertes, Rodolphe Tamion, Hervé Wyart
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Patent number: 7102027Abstract: An adamantanetricarboxylic acid derivative is represented by following Formula (1): wherein X is a hydrogen atom or a hydrocarbon group; and R1, R2 and R3 may be the same as or different from one another and are each a carboxyl group which may be protected by a protecting group, or a carbonyl halide group, wherein at least one of R1, R2 and R3 is a carboxyl group which is protected by a protecting group, or a carbonyl halide group.Type: GrantFiled: March 24, 2004Date of Patent: September 5, 2006Assignee: Daicel Chemical Industries, Ltd.Inventors: Shinya Nagano, Jiichiro Hashimoto
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Patent number: 7052742Abstract: Fluorinated five-membered ring compounds of the formula (I) R1—X—(A1—M1)a—(A2—M2)b—A3—Y—E ??(I) where E is a radical T—Z—R2 containing a five-membered ring and, for example, T is undirected and is 4-fluorothiophene-2,5-diyl, 3-fluorothiophene-2,5-diyl, 3-fluorothiophene-2,4-diyl, 5-fluorothiophene-2,4-diyl, furan-2,5-diyl, furan-2,4-diyl, isoxazole-3,5-diyl, thiazole-2,5-diyl, thiazole-2,4-diyl, cyclopentane-1,3-diyl or cyclopentene-1,3-diyl, R1 and R2 are hydrogen, X is a single bond, —O—, OC(?O)—, —C(?O)O— or —OC(?O)O—, Y is —OC(?O)—, —OCH2—, —CH2CH2—, Z is a single bond or —O—, A1, A2, A3 are each, independently of one another, phenylene-1,4-diyl, M1, M2 are undirected and are each, independently of one another, —OC(?O)—, —OCH2—, —CH2CH2—, —OC(?O)CH2CH2—, —OCH2CH2CH2—, —C?C—, —CH2CH2CH2CH2— or a single bond, a, b are each, independently of one another, 0 or 1, are used in FLC mixtures.Type: GrantFiled: August 31, 2000Date of Patent: May 30, 2006Assignee: Clariant International Ltd.Inventors: Barbara Hornung, Toshiaki Nonaka, Ayako Ogawa, Wolfgang Schmidt, Rainer Wingen
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Patent number: 7049338Abstract: This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents, especially tumor growth inhibitors and anti-cancer agents, antibiotics and/or antiviral agents.Type: GrantFiled: March 9, 2005Date of Patent: May 23, 2006Inventors: Washington Odur Ayuko, Michael John Tisdale, Eric Lattmann
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Patent number: 7037937Abstract: Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular proliferation, for example, as effective anti-cancer agents. The compounds can also induce cytotoxicity in cells such as leukemia cells. The chemical structure of the compounds includes a furan, thiophene, thiazole, oxazole, or imidazole group at one end of the molecule (head) and a hydrophobic, aliphatic chain at the other end of the molecule (tail).Type: GrantFiled: May 11, 2004Date of Patent: May 2, 2006Assignee: Parker Hughes InstituteInventors: Fatih M. Uckun, Shyi-Tai M. Jan
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Patent number: 7029606Abstract: A dihydrofuran-containing nonlinear optical chromophore having a ?-electron donor group conjugated to the dihydrofuran group through a ?-electron conjugated bridge group. The nonlinear optical chromophore is a hyperpolarizable chromophore that can be used as an electro-optic modulator in electro-optic devices.Type: GrantFiled: July 24, 2001Date of Patent: April 18, 2006Assignee: University of WashingtonInventors: Larry R. Dalton, Kwan-Yue Jen, Timothy Londergan, William Brenden Carlson, Gregory Phelan, Diyun Huang, Daniel Casmier, Todd Ewy, Nicholas Buker
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Patent number: 6969731Abstract: HIV protease inhibitors are among the most powerful drugs in suppressing HIV in human patients. However, HIV developed resistance to all protease inhibitor drugs so far marketed or used in clinical trials. HIV generates resistance by mutating its protease. The strains of HIV containing mutant proteases less vulnerable to inhibitor drug are able to replicate better and maintain the infection. No effective principle exists for the design of resistance-proof HIV protease inhibitors (HIVPr). A new inhibitor has been developed based on a new concept for designing resistance invulnerable HIVPr inhibitors. In vitro data have shown that this inhibitor is effective against many known HIVPr mutants resistant to other HIVPr inhibitor drugs. The new concept is, therefore, generally applicable for the design of other resistance invulnerable HIVPr inhibitor drugs.Type: GrantFiled: February 18, 2000Date of Patent: November 29, 2005Assignees: The University of Illinois, Board of Trustees, The Oklahoma Medical Research FoundationInventors: Jordan J. N. Tang, Arun K. Ghosh
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Patent number: 6964981Abstract: The present invention relates compounds that are NK-1 antagonists and that are of use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.Type: GrantFiled: September 10, 2001Date of Patent: November 15, 2005Assignee: Merck Sharp & Dohme Ltd.Inventors: Brian John Williams, Christopher John Swain, Simon Neil Owen
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Patent number: 6906196Abstract: Provided are processes and chemical intermediates useful for preparing a compound of the formula I wherein X is selected from the group consisting of C1-C6 trihalomethyl; C1-C6 alkyl; and an optionally substituted or di-substituted phenyl group of formula II: Y and Z are independently selected from the group consisting of substituted and unsubstiotuted arylType: GrantFiled: September 18, 2002Date of Patent: June 14, 2005Assignee: Onconova Therapeutics, Inc.Inventors: M. V. Ramana Reddy, Stanley C. Bell
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Patent number: 6897324Abstract: For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound for formula (1) wherein the bond between carbon atoms y and z is either a single or double bond; R1 is selected from vinyl, trialkylsilylethynyl, a formyl group protected as an acetal, or a protected hydroxymethyl group; R2 is C1-5 alkyl, optionally substituted at the terminus with an aryloxy or alkoxy group; and R3-R6 are independently selected from C1-6 alkyl and C6-10 arylType: GrantFiled: May 16, 2001Date of Patent: May 24, 2005Assignee: Chirotech Technology LimitedInventors: Martin Edward Fox, Mark Jackson
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Patent number: 6875784Abstract: The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.Type: GrantFiled: October 2, 2003Date of Patent: April 5, 2005Assignee: Pharmacia & Upjohn CompanyInventors: Mikhail Fedor Gordeev, Adam Renslo, Dinesh Vinoobhai Patel
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Patent number: 6864285Abstract: The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as agonists of the CB2 cannabinoid receptor and hence as drugs active in pathological conditions which can be controlled by stimulation and/or costimulation of this receptorType: GrantFiled: July 7, 1999Date of Patent: March 8, 2005Assignee: Innovet Italia S.r.l.Inventors: Cristina Comelli, Francesco Della Valle, Maria Federica Della Valle, Gabriele Marcolongo
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Patent number: 6864283Abstract: Compounds of formula (I) wherein R1is selected from H, C(?O)R?, P(?O)R?R?, S(?O)R?R?, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, or substituted or unsubstituted aryl; or R1 together with R2 forms a saturated or unsaturated heterocyclic ring; R2 and R3 are each, independently, selected from H, C(?O)R?, P(?O)R?R?, S(?O)R?R?, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, or substituted or unsubstituted aryl; or one of R2 or R3 together with R1 forms a saturated or unsaturated heterocyclic ring; or R2 and R3 together form a saturated or unsaturated heterocyclic ring; R4 is selected from H, C(?O)R?, P(?O)R?R?, S(?O)R?R?, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18, alkynyl, or substituted or unsubstituted aryl, wherein R? is selected from the group consisting ofType: GrantFiled: February 16, 2001Date of Patent: March 8, 2005Assignee: Pharma Mar, S.A.Inventors: Tatsuo Higa, Junichi Tanaka, Dolores Garcia Gravalos
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Patent number: 6849733Abstract: There are disclosed novel neuropeptide Y ligands having the general formula I Wherein the symbols W, A, D, R1, R2, R3, R4 are further defined in the description. Compounds of formula I are agonists and antagonists of neuropeptide Y, and are therefore useful as regulators.Type: GrantFiled: August 22, 1997Date of Patent: February 1, 2005Assignee: Agouron Pharmaceuticals, Inc.Inventors: Yufeng Hong, Vlad Edward Gregor, Anthony Lai Ling, Eileen Valenzuela Tompkins
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Patent number: 6844452Abstract: A process for the co-production of a diol product (e.g. butane-1,4-diol) and a cyclic ether (e.g. tetrahydrofuran) by hydrogenation of an aliphatic diester or lactone feedstock (e.g. dimethyl or diethyl maleate), which contains a minor amount of acidic material, such as the corresponding monoester. The process utilizes a plurality of hydrogenation zones connected in series, each containing a charge of a granular ester hydrogenation catalyst. The catalyst in the first hydrogenation zone is tolerant of a minor amount of acidic material, while the catalyst in the second hydrogenation zone provides enhanced yields of cyclic ethers compared to the catalyst of the first hydrogenation zone. The catalyst in a third hydrogenation zone exhibits low selectivity towards conversion of the diester to at least one by product (e.g. 2-4?-hydroxybutoxy-tetrahydrofuran).Type: GrantFiled: December 12, 2000Date of Patent: January 18, 2005Assignee: Davy Process Technology Ltd.Inventors: Michael Anthony Wood, Paul Willett, Robert Wild, Stephen William Colley
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Patent number: 6841571Abstract: Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R2, R3, R4, R6, R8 and Y are defined herein. The compounds are useful for treating autoimmune and other diseases.Type: GrantFiled: October 24, 2002Date of Patent: January 11, 2005Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Younes Bekkali, Denice Mary Spero, Sanxing Sun, Yancey David Ward
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Patent number: 6833462Abstract: An acrylate compound of formula (4): is produced by allowing an acrylic acid compound of formula (1): to react with an unsaturated compound of formula (2) or (3): In formulae (1) through (4), R1 and R2 are H or F, R3 is H, F, or an alkyl, alkenyl, fluoroalkyl or fluoroalkenyl group, R4 and R5 are H, halogen, or an alkyl, alkenyl, halogenated alkyl or halogenated alkenyl group; and X and Y are an unsubstituted or substituted hydrocarbon group, and dashed line - - - means that X and Y may be bonded together to form a cyclic structure.Type: GrantFiled: November 26, 2002Date of Patent: December 21, 2004Assignee: Tosoh CorporationInventors: Shinichi Ishikawa, Hisao Eguchi
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Patent number: 6818664Abstract: A compound represented by the following formula (I) or a salt thereof and a medicament such as an angiogenesis inhibitor and an antitumor agent which comprises said compound or a physiologically acceptable salt thereof as an active ingredient.Type: GrantFiled: September 23, 2002Date of Patent: November 16, 2004Assignees: Riken, Institute of Biotechnology Applied to Soil EumycetesInventors: Hiroyuki Osada, Hideaki Kakeya, Hiroshi Konno, Susumu Kanazawa
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Publication number: 20040204452Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.Type: ApplicationFiled: April 10, 2003Publication date: October 14, 2004Applicant: Schering AGInventors: Thorsten Blume, Roland Neuhaus, Detlev Suelzle, Iris Pribilla, Gisbert Depke, Joseph S. Beckman
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Publication number: 20040204454Abstract: The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I:Type: ApplicationFiled: March 16, 2004Publication date: October 14, 2004Inventors: Jennifer X. Qiao, Tammy C. Wang
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Publication number: 20040142975Abstract: Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes.Type: ApplicationFiled: December 23, 2003Publication date: July 22, 2004Applicant: The Procter &Gamble CompanyInventors: Stanislaw Pikul, Norman Eugene Ohler, Kelly Michelle Solinsky, Neil Gregory Almstead, Biswanath De, Michael George Natchus
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Patent number: 6764829Abstract: The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I) where X is OH, or H, and Y is the residue of Y—OH where Y—OH is a chromophore or a compound readily converted to a chromophore and the substrates are hydrolyzed by the nucleoside hydrolase to yield ribose or 2-deoxyribose plus Y—OH. Alternatively, those substrates may be phosphorylysed by nucleoside phosphorylase to yield ribose-1-phosphate plus Y—OH. The methods may be used to detect and/or assay parasites in biological samples.Type: GrantFiled: March 18, 2002Date of Patent: July 20, 2004Assignees: Albert Einstein College of Medicine of Yeshiva University, Industrial Research LimitedInventors: Vern L. Schramm, Richard Hubert Furneaux, Peter Charles Tyler, Keith Clinch
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Publication number: 20040110969Abstract: The invention concerns a method for purifying a composition containing at least a product for internal dehydration of a hydrogenated sugar. The invention is characterised in that it comprises: (a) an optional step whereby said composition is treated, whether after re-dissolving or not, with at least a discoloration means; (b) a subsequent step whereby the composition, optionally treated with discoloration means, is treated with at least ion-exchanging means; (c) a subsequent step whereby the resulting composition is treated with at least discoloration means. Said method is in particular applicable to isohexide compositions, in particular isosorbide or isomannide. The resulting compositions, which exhibit particular characteristics in terms of purity and proportion of some impurities, constitute novel products for use in chemical, pharmaceutical, cosmetology and food industries.Type: ApplicationFiled: December 6, 2002Publication date: June 10, 2004Inventors: Guy Fleche, Patrick Fuertes, Rodolphe Tamion, Herve Wyart
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Publication number: 20040063968Abstract: Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.Type: ApplicationFiled: September 16, 2003Publication date: April 1, 2004Inventors: Pete Delgado, Raymond E. Conrow, William D. Dean, Michael S. Gaines
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Patent number: 6710078Abstract: Compounds of Formula (I): wherein R1, R2, R3, X, Y, Z and Q are as defined in the specification which compounds are inhibitors of Ras farnesyl-protein transferase enzyme (FPTase), and useful in treating ras oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid and processes for the preparation of said compounds of Formula (I).Type: GrantFiled: August 23, 2002Date of Patent: March 23, 2004Assignee: Wyeth Holdings CorporationInventors: Semiramis Ayral-Kaloustian, Irwin Hollander, Ann Aulabaugh
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Publication number: 20040030141Abstract: Compounds of formula (I): 1Type: ApplicationFiled: July 7, 2003Publication date: February 12, 2004Applicant: Galderma Research & DevelopmentInventors: Jean-Michel Bernardon, Philippe Nedoncelle
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Patent number: 6673934Abstract: Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is hydrogen, hydroxy, nitro, amino, halogen, C1 to C5 alkyl or haloalkyl, C1 to C5 alkoxy or cyclic alkoxy, C1 to C5 hydroxyalkyl and C1 to C5 hydroxyalkoxy; Ar is an aromatic group, preferably an aromatic group selected from a furanyl, thienyl, pyridinyl, phenyl, 2,3-dihydro-benzo[1,4]dioxin-5 or -6-yl or benzo[1,3]dioxol-4 or -5-yl group; and y=1 to 3.Type: GrantFiled: January 18, 2002Date of Patent: January 6, 2004Assignee: The Procter & Gamble CompanyInventors: Mu-Ill Lim, Yuh-Guo Pan
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Publication number: 20030208084Abstract: Thienyl-, furyl- and pyrrolyl-sulfonamides, formulations of pharmaceutically-acceptable salts thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides, formulations thereof and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit the activity of endothelin are also provided.Type: ApplicationFiled: May 28, 2003Publication date: November 6, 2003Inventors: Chengde Wu, Bore Gowda Raju, Timothy Kogan, Natalie Blok, Patricia Woodard
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Publication number: 20030199500Abstract: The present invention relates compounds of the formula (1): wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 represent a variety of substituents; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.Type: ApplicationFiled: March 18, 2003Publication date: October 23, 2003Inventors: Brian John Williams, Christopher John Swain, Simon Neil Owen
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Patent number: 6620947Abstract: Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.Type: GrantFiled: August 26, 2002Date of Patent: September 16, 2003Assignee: Alcon, Inc.Inventors: Pete Delgado, Raymond E. Conrow, William D. Dean, Michael S. Gaines
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Publication number: 20030171431Abstract: The present invention relates to a 2-fluoro-2-(3-oxobicyclopentyl)acetate derivative represented by the formula (1): 1Type: ApplicationFiled: December 17, 2002Publication date: September 11, 2003Inventors: Atsuro Nakazato, Toshihito Kumagai, Kazunari Sakagami, Takeo Taguchi
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Publication number: 20030166668Abstract: Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: ApplicationFiled: November 14, 2002Publication date: September 4, 2003Applicant: The Institutes for Pharmaceutical Discovery, Inc. A Corporation of the State of DelawareInventors: Michael C. Van Zandt, Leo Geraci
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Patent number: 6613743Abstract: The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity. The sulfonamides of formula I have the structure: wherein A, B, D, D′, E, G and R7 are as defined above.Type: GrantFiled: December 6, 2000Date of Patent: September 2, 2003Assignee: Vertex Pharmaceuticals IncorporatedInventors: Michael Robin Hale, Clarence Webster Andrews, III, Eric Steven Furfine, Ronald George Sherrill, Andrew Spaltenstein, Gregory Thomas Lowen
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Patent number: 6593478Abstract: A new, more efficient and highly stereospecific process is described for the preparation of compounds with general formula (R)-(I) and of absolute configuration (R), where the groups M, W, Q and Q1 are as defined in the description, starting from compounds of absolute configuration (S) by hydrolysis, in the presence of acids, of the corresponding esterified derivatives. The (R)-(I) products obtained with the process described herein are chiral synthons useful for the production of enanthiomerically pure drugs. The preparation of (R)-carnitine is also provided.Type: GrantFiled: June 24, 2002Date of Patent: July 15, 2003Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Oreste Piccolo, Roberto Castagnani, Paolo De Witt
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Publication number: 20030125489Abstract: The invention relates to a compound of formula Ia, Ib or Ic 1Type: ApplicationFiled: November 18, 2002Publication date: July 3, 2003Inventors: Peter Nesvadba, Andreas Kramer, Marie-Odile Zink, Dario Lazzari
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Publication number: 20030100580Abstract: P51084 The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.Type: ApplicationFiled: June 13, 2002Publication date: May 29, 2003Inventors: Dashyant Dhanak, Steven David Knight
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Publication number: 20030100583Abstract: Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.Type: ApplicationFiled: August 9, 2002Publication date: May 29, 2003Applicant: Galderma Research & DevelopmentInventors: Jean-Michel Bernardon, Philippe Diaz
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Patent number: 6566375Abstract: Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis.Type: GrantFiled: April 26, 2001Date of Patent: May 20, 2003Assignee: WyethInventor: Thomas J. Commons
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Patent number: 6559137Abstract: The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.Type: GrantFiled: June 23, 2000Date of Patent: May 6, 2003Assignee: Vertex Pharmaceuticals IncorporatedInventors: Roger Dennis Tung, Michael Robin Hale, Christopher Todd Baker, Eric Steven Furfine, Istvan Kaldor, Wieslaw Mieczylaw Kazmierski, Andrew Spaltenstein