The Carbonyl Is Part Of A Carboxamide Group (i.e., Fatty Acid Amides) Patents (Class 554/35)
  • Patent number: 7585856
    Abstract: The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: September 8, 2009
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Charles N. Serhan
  • Patent number: 7582782
    Abstract: Disclosed are ?-amino-?-hydroxy-?-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
    Type: Grant
    Filed: November 25, 2004
    Date of Patent: September 1, 2009
    Assignee: Novartis AG
    Inventors: Daniel K Baeschlin, Juergen K Maibaum, Holger Sellner
  • Patent number: 7582306
    Abstract: The present invention relates to a pseudoceramide represented by the following formula (I) and a cosmetic composition comprising the same: wherein Z represents —OH and Y represents —OH, ?with the proviso that X is Z represents —OH and X represents —OH, with the proviso that Y is Y represents —OH and X represents —OH, with the proviso that Z is R represents a linear or branched, saturated or unsaturated aliphatic hydrocarbon group; and when substituted, R has one or more —OH groups.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: September 1, 2009
    Assignee: Coreana Cosmetics Co., Ltd.
    Inventors: Jung-No Lee, Kang-Tae Lee, Jee-Hean Jeong, Byong-Kee Jo
  • Publication number: 20090203778
    Abstract: A compound of formula (I) wherein R1 and R2 are different and each is chosen from a methyl group and a hydrogen atom; wherein X is chosen from a carboxylic acid group, a carboxylate group, a carboxamide group; or any pharmaceutically acceptable salt, solvate, complex, or pro-drug of said compound. A pharmaceutical composition and a lipid composition comprising a compound of formula (I) is also disclosed. A method for the treatment of obesity, diabetes mellitus, amyloidos-related diseases, cardiovascular-diseases, and cerebrovascular diseases is also disclosed.
    Type: Application
    Filed: May 4, 2006
    Publication date: August 13, 2009
    Inventors: Morten Bryhn, Anne Kristin Holmeide, Jan Kopecky
  • Patent number: 7541055
    Abstract: The present invention is directed to novel compounds and a process for augmenting or imparting a flavor enhancement effect or modifying the perception of one or more of the five basic taste qualities sweet, sour, salt, bitter and umami, to a foodstuff, chewing gum, medicinal product, toothpaste, alcoholic beverage, aqueous beverage, snack, sauce or soup comprising the step of adding to a foodstuff, chewing gum, medicinal product, toothpaste, alcoholic beverage, aqueous beverage, snack, sauce or soup a flavor enhancement or modification of basic taste quality augmenting, enhancing or imparting quantity and concentration of at least one N-substituted unsaturated alkyl amide defined according to the structures:
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: June 2, 2009
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark L. Dewis, Garry Conkiln, Tao Pei, Catherine Marie Smith, Adam Jan Janczuk
  • Publication number: 20080306153
    Abstract: Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety??(II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8.
    Type: Application
    Filed: December 19, 2007
    Publication date: December 11, 2008
    Inventors: Steffen Panzner, Evgenios Siepi, Silke Lutz, Christian Reinsch, Claudia Muller
  • Publication number: 20080234375
    Abstract: The invention relates to a process for decreasing the amount of environmental pollutants in a mixture comprising a fat or an oil, being edible or for use in cosmetics, the fat or oil containing the environmental pollutants, which process comprises the steps of adding a volatile working fluid to the mixture, where the volatile working fluid comprises at least one of a fatty acid ester, a fatty acid amid, a free fatty acid and a hydrocarbon, and subjecting the mixture with the added volatile working fluid to at least one stripping processing step, in which an amount of environmental pollutant present in the fat or oil, being edible or for use in cosmetics, is separated from the mixture together with the volatile working fluid. The present invention also relates to a volatile environmental pollutants decreasing working fluid, for use in decreasing an amount of environmental pollutants present in a fat or oil, being edible or for use in cosmetics.
    Type: Application
    Filed: May 1, 2008
    Publication date: September 25, 2008
    Inventors: Harald Breivik, Olay Thorstad
  • Patent number: 7427421
    Abstract: Saturated and unsaturated compounds having sweet, salt or umami taste enhancement qualities. The compounds have the structure: where R1?H or methyl; R2 is selected from the group consisting of H, C1-C4 alkyl, alkenyl and methylene; R3 is selected from the group consisting of H, C1-C8 straight or branched chain alkyl, alkenyl, dienalkyl or phenyl; or if R1?H, R2 and R3 taken together can represent cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, or cyclohexenyl; R4 is selected from the group consisting of H, methyl and ethyl; R5 is selected from the group consisting of H, methyl and ethyl; R6 is selected from the group consisting of H, C1-C9 straight or branched chain alkyl, alkenyl, alkyldienyl, acyclic or containing no more than one ring; with the proviso that in structure 1 when R4 is H or Me; and R5?H or methyl, R6 may be selected from the group described above or phenyl.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: September 23, 2008
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark L. Dewis, Garry Conklin, Tao Pei
  • Publication number: 20080200704
    Abstract: The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an amide linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
    Type: Application
    Filed: September 14, 2007
    Publication date: August 21, 2008
    Applicant: MULTI FORMULATIONS LTD.
    Inventors: Shan Chaudhuri, Joseph MacDougall, Jason Peters, James Ramsbottom
  • Patent number: 7361376
    Abstract: Alkyldienamides compounds suitable for use as flavoring agents are disclosed. The compounds are used as flavors since they possess umami characteristics or other desirable organoleptic properties. The disclosed compounds are defined by the structure set forth below: wherein R is methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyl, sec-butyl, isobutyl, cyclobutyl, CH2CH(CH3)CH2CH3, CH2CH(OH)CH3, CH(CH3)CH2OH, CH2C(CH3)2OH, CH2CH2OH, cyclopentyl or allyl; and wherein R? is methyl, ethyl, n-propyl, n-butyl or n-pentyl, n-hexyl.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: April 22, 2008
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark L. Dewis, Michelle E. Huber, Michael V. Cossette, David O. Agyemang
  • Patent number: 7344621
    Abstract: A paper additive composition comprising an amide compound (a) obtained by reacting a polyamine and a carboxylic acid or a salt of the amide compound (a) is provided. The polyamine is shown by formula (1): R—(NH—R1)n-NH2??(1) (wherein R is H2N—R1 or R2, and each R1 is independently an alkylene group having 1 to 4 carbon atoms, R2 is an alkyl group or alkenyl group having 12 to 22 carbon atoms, and n is an integer of 1 to 3); the number of carbon atoms of the carboxylic acid is 10 to 24; the amide compound is obtained by reacting the carboxylic acid at a ratio of 0.5 to 4.3 moles per 1 mol of the polyamine; and the ratio of a tertiary amine value to a total amine value of the amide compound (a) is 0.60 to 0.99.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: March 18, 2008
    Assignee: NOF Corporation
    Inventors: Yasuyuki Nakamura, Tetsuya Tamai, Kazumichi Asakura
  • Patent number: 7329767
    Abstract: Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: February 12, 2008
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark L. Dewis, Thumplasseril V. John, Markus A. Eckert, Jan Herman Colstee, Neil C. Da Costa, Tao Pei
  • Patent number: 7319157
    Abstract: The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: January 15, 2008
    Assignee: Multi Formulations Ltd.
    Inventors: Shan Chaudhuri, Joseph MacDougall, Jason Peters, James Ramsbottom
  • Patent number: 7276613
    Abstract: Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy, as well as suppression of the immune system, enhancement of appetite and in treatment of certain mental disorders.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: October 2, 2007
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Qian Liu, Andreas Goutopoulos
  • Patent number: 7244419
    Abstract: A compound represented by the following general formula (I), wherein R1 and R2 represent a hydrocarbon group having 1 to 26 carbon atoms, preferably a linear or branched alkyl group, R3 represents a hydrocarbon group having 7 to 10 carbon atoms, preferably a linear or branched alkyl group, n represents 1 or 2 provided that the acidic amino acid residue in the molecule is L-aspartic acid residue when n is 1 and said acidic amino acid residue is L-glutamic acid residue when n is 2, and a gelling agent for an oil comprising said compound
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: July 17, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Naoya Yamato, Hideki Yoshihara
  • Patent number: 7235586
    Abstract: The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: wherein a wavy segments indicate either the alpha (?) or beta (?) configuration; the dashed bond represents a double bond or a single bond; U, Y, X, R1, Ar, n, x and y are as defined in the specification.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: June 26, 2007
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Robert M. Burk
  • Patent number: 7214384
    Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: May 8, 2007
    Assignee: Novartis Vaccines And Diagnostics, Inc.
    Inventors: Ronald N. Zuckermann, Chin-Yi Huang, John E. Murphy, Tetsuo Uno
  • Patent number: 7183432
    Abstract: A method of synthesizing diacetylenic amides is described. The key steps of the invention include the reaction of an aldehyde with the monoanion of a diacetylene and the reductive removal of a propargylic alcohol. The invention offers the first known method of synthesizing diacetylenic amides that are naturally isolated from Echinacea through a direct and flexible route.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: February 27, 2007
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: George A. Kraus, Jaehoon Bae
  • Patent number: 7141686
    Abstract: Described is a genus of E2,E4,Z8-undecatrienoic acid derivatives defined according to the structure: wherein Z represents —OR? or —NRR? with the provisos that when Z is —OR?, R? is hydrogen, C1–C6 straight chain or branched-chain alkyl or C3–C6 straight chain or branched-chain alkenyl; and when Z is —NRR?, R represents, in the alternative, hydrogen, methyl or ethyl and R? represents methyl, ethyl, n-propyl, cyclopropyl, isopropyl, n-butyl, sec-butyl, isobutyl, 2-methylbutyl, cyclobutyl, cyclopentyl or allyl. The E2,E4,Z8-undecatrienoic acid derivatives are useful in imparting, augmenting and/or enhancing flavors, aromas and somatosensory effects in or to consumable materials such as foods, beverages, skin care products, oral care products, medicinal products and the like. Also described is a synthesis process for producing such derivatives.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: November 28, 2006
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark L. Dewis, Michelle E. Huber
  • Patent number: 6982092
    Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: January 3, 2006
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Chin-Yi Huang, John E. Murphy, Tetsuo Uno
  • Patent number: 6979744
    Abstract: The present invention relates to a class of compounds having specific betaines based upon a dimer acid amido amine. Dimer acid is a C-36 diacid having a cyclic structure and two amine groups that allow for the synthesis of a high molecular weight material quaternary compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of personal care products.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: December 27, 2005
    Assignee: SurfaTech Corporation
    Inventors: Anthony J. O'Lenick, Jr., Thomas G. O'Lenick, Kevin A. O'Lenick
  • Patent number: 6888015
    Abstract: A inhibitor of sphingolipids synthesis comprising a compound represented by general formula A. Desirably, a novel inhibitor of sphingolipids synthesis comprising (1R, 3R) N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl) alkaneamide, wherein carbon number of alkanoyl group is 8-16. (in the formula, X is an aliphatic alkyl group, desirably is an aliphatic alkyl group having 7 to 15 carbon atoms).
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: May 3, 2005
    Assignee: Japan Science and Technology Agency
    Inventors: Shu Kobayashi, Kentaro Hanada
  • Patent number: 6861542
    Abstract: The present invention relates to a class of compounds having specific quaternized amine based upon a dimer acid amido amine linked to specific phosphate esters. Dimer acid is a C-36 diacid having a cyclic structure and two amine groups that allow for the synthesis of a high molecular weight material quaternary compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: March 1, 2005
    Assignee: SurfaTech Corporation
    Inventors: Anthony J. O'Lenick, Jr., Thomas G. O'Lenick
  • Publication number: 20040254165
    Abstract: The present invention provides compounds of formula (I) and analogues or derivatives thereof for the treatment of skin conditions, such as Vitiligo, which are treatable by the stimulation of melanocyte proliferation and also for treating skin cancer. The compounds may also be used to cosmetically enhance the natural coloration of the skin.
    Type: Application
    Filed: January 30, 2004
    Publication date: December 16, 2004
    Inventors: Amala Soumyanath, Robert Charles Hider, Radhakrishnan Venkatasamy
  • Publication number: 20040122102
    Abstract: The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)]heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
    Type: Application
    Filed: December 10, 2003
    Publication date: June 24, 2004
    Applicant: ALLERGAN, INC.
    Inventor: Robert M. Burk
  • Publication number: 20040116408
    Abstract: The present invention is generally drawn to novel isolated therapeutic agents, termed resolving, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
    Type: Application
    Filed: August 12, 2003
    Publication date: June 17, 2004
    Inventor: Charles N. Serhan
  • Patent number: 6713511
    Abstract: The invention relates to a novel acylate which is the reaction product of (a) a substance which is selected from the group consisting of naturally occuring alpha-aminocarboxylic acids, neurotransmitters other than such acids, and central or peripheral nervous system pharmacologically active compounds, and containing a functional group including an acylatable hydrogen atom, or a reactive derivative thereof; and (b) an essential fatty acid or a reactive derivative thereof; and including the pharmaceutically acceptable salts of such acylates possessing a basic and (or) acidic function; and to their functional derivatives. The acylates and their functional derivatives may be used for treatment of a disease or condition related to a neurotransmitter defector deficiency, or to another central or peripheral nervous system defect or deficiency, and in particular Parkinson's disease.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: March 30, 2004
    Inventor: Zvi Yehuda
  • Patent number: 6696038
    Abstract: A biodegradable, novel cationic lipopolymer comprising a branched polyethylenimine(PEI), a cholesterol derived lipid anchor, and a biodegradable linker which covalently links the branched PEI and cholesterol derived lipid anchor. One example of such a novel lipolymer is poly{(ethylene imine)-co-[N-2-aminoehtyl)ethylene imine]-co-[N-(N-cholesteryloxycabonyl-(2-aminoethyl))ethylene imine]} (“PEACE”). The cationic lipopolymers in the present invention can be used in drug delivery and are especially useful for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration. Methods of preparing and using the cationic lipopolymer gene carriers of the present invention to efficiently transfect cells, both in vitro and in vivo, are disclosed.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: February 24, 2004
    Assignee: Expression Genetics, Inc.
    Inventors: Ram I. Mahato, Sang-Oh Han, Darin Y. Furgeson
  • Publication number: 20030139376
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): 1
    Type: Application
    Filed: October 22, 2002
    Publication date: July 24, 2003
    Applicant: Schering Aktiengesellschaft
    Inventors: John G. Bauman, William J. Guilford, John F. Parkinson, Werner Skuballa, Babu Subramanyam
  • Patent number: 6583301
    Abstract: Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: June 24, 2003
    Assignee: Celltech R & D Limited
    Inventors: Michael Anthony William Eaton, Timothy John Norman, David Parker, Terence Seward Baker, Andrew Neil Charles Weir, Catherine Fiona Catterall
  • Patent number: 6572881
    Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: June 3, 2003
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Chin-Yi Huang, John E. Murphy, Tetsuo Uno
  • Patent number: 6569450
    Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: May 27, 2003
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Chin-Yi Huang, John E. Murphy, Tetsuo Uno
  • Patent number: 6552206
    Abstract: The invention relates to compositions that can be isolated from Lepidium plant material and to methods for their isolation. The compositions are useful for treating and preventing cancer and sexual dysfunction.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: April 22, 2003
    Assignee: Pure World Botanicals, Inc.
    Inventors: Bo Lin Zheng, Kan He, Yu Shao, Qun Yi Zheng
  • Patent number: 6524353
    Abstract: A fuel additive composition composed of the reaction product of (a) mixed fatty acid esters; (b) a mono or di-(hydroxy alkyl amine) or mixtures thereof; and (c) a low temperature property enhancing effective amount of a low molecular weight ester; wherein the reaction mixture has a molar ratio of amine to total ester content in the range from 10.0 to 1.0. The fuel additive exhibits detergent and friction reducing properties when added to a fuel thereto and further exhibits good low temperature stability properties. Methods for making the inventive composition and fuel compositions containing the additive are also disclosed.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: February 25, 2003
    Assignee: Texaco Development Corporation
    Inventors: Thomas F. de Rosa, Benjamin J. Kaufman, Frank J. DeBlase, James R. Ketcham, Michael G. Rawdon, Max R. Cesar
  • Patent number: 6518311
    Abstract: The present invention relates to compounds and pharmaceutical compositions useful for treating pain. The invention also relates to methods of treating or alleviating pain in mammals, comprising administering to a mammal suffering from pain, a pain-alleviating amount of a compound of the general formula (I) or (II).
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: February 11, 2003
    Assignee: D-Pharm Ltd.
    Inventors: Alexander Kozak, Revital Duvdevani, Firas M. Younis
  • Patent number: 6515178
    Abstract: The invention concerns a composition, in particular a cosmetic composition, comprising at least a powder substance and a branched amide used as dispersion agent The invention also concerns novel branched amides of formula (I′).
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: February 4, 2003
    Assignee: L'Oreal
    Inventors: Michel Philippe, Didier Semeria
  • Publication number: 20020188144
    Abstract: The invention concerns a composition, in particular a cosmetic composition, comprising at least a powder substance and a branched amide used as dispersion agent. The invention also concerns novel branched amides of formula (I′).
    Type: Application
    Filed: October 31, 2001
    Publication date: December 12, 2002
    Applicant: L'Oreal
    Inventors: Michel Philippe, Didier Semeria
  • Patent number: 6482985
    Abstract: Disclosed is a compound comprising a 2-benzyloxy-5-haloacylanilide having the structural formula I: wherein R is hydrogen or an alkyl group, RA is a substituent and n is 0-5; and X is a halogen. Also disclosed is a method for preparing a coupler using the compound. The compound and method simplify the preparation of photographic couplers.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: November 19, 2002
    Assignee: Eastman Kodak Company
    Inventor: Chang-Kyu Kim
  • Patent number: 6448366
    Abstract: An improved thickening composition for organic systems, including paints and coatings, is described. The additive provides paints and coatings more than adequate viscosity improvement without affecting intercoat adhesion characteristics.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: September 10, 2002
    Assignee: Elementis Specialties, Inc.
    Inventors: Mahalingam Santhanam, Wilbur S. Mardis
  • Patent number: 6399798
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide (hereinafter referred to as a “protected/activated salicylamide”). The method comprises the steps of (a) alkylating the protected/activated salicylamide with an alkylating agent to form a protected/activated alkylated salicylamide, and (b) deprotecting and deactivating the protected/activated alkylated salicylamide, simultaneously or in any order, to form the alkylated salicylamide. The alkylated salicylamides prepared by this method are suitable for use in compositions for delivering active agents via oral or other routes of administration to animals.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: June 4, 2002
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gschneidner, Joseph N. Bernadino, William E. Bay
  • Patent number: 6369248
    Abstract: Compounds having formula (I) in which n is 1, 2 or 3 and R1 to R6 represent, independently, branched or unbranched, substituted or unsubstituted alkyl-, alkenyl-, alkinyl-, cycloalkyl-, cycloalkenyl- or aromatic-radicals or hydrogen wherein these radicals may in addition contain one or more —O— and/or (a)—groups, whereby one or two rings can be built by the combination of the respective R1 to R6 and this/these ring(s) can be further substituted by an alkyl-group, in which X is either O and R7 represents a radical of an alcohol or phenol R7OH, or X is N and R7 represents the radical of an amine R7′R7″NH, whereby R7′ and R7″ represent independently, branched or unbranched, substituted or unsubstituted alkyl-, alkenyl-, alkinyl-, cycloalkyl-, cycloalkenyl- or aromatic radicals or either R7′R7″ may be hydrogen, whereby the amine is a fragrant amine or the amine has more than 9 C atoms, whereby R7 of the alcohol or phenol and R7′ and/or R7″ of the a
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: April 9, 2002
    Assignee: Givaudan SA
    Inventors: Denise Anderson, Georg Frater
  • Patent number: 6369249
    Abstract: The present invention relates to a process for the preparation of N-substituted acrylamides of the general formula CH2═CH—CONHR, wherein, R is alkyl group having carbon 1 to 22 or acyl group having carbon 1 to 18. The process for the preparation of the N-substituted acrylamides comprises reacting acrylamide with alkyl acyl chloride in the presence of Lewis acid catalyst in an organic solvent at a temperature ranging between room temperature to 50° C. for a period ranging between 1 hour to 24 hours.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: April 9, 2002
    Assignee: Council of Scientific & Industrial Research
    Inventors: Bhalchandra Shripad Lele, Mohan Gopalkrishna Kulkarni
  • Patent number: 6359175
    Abstract: The invention concerns a composition, in particular a cosmetic composition, comprising at least a powder substance and a branched amide used as dispersion agent. The invention also concerns novel branched amides of formula (I′).
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: March 19, 2002
    Assignee: L'Oreal S.A.
    Inventors: Michel Philippe, Didier Semeria
  • Publication number: 20020019416
    Abstract: 1 The present invention relates to a novel fatty acid derivative of formula (I), wherein R1 is acyl group; R2 is acyl(lower)alkyl; R3 is hydrogen, aryl(lower)alkyl, etc.; R4 is acyl(lower)alkyl; and X is —O—, —NH— or formula (II) [wherein R5 is lower alkyl, etc.]; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
    Type: Application
    Filed: April 20, 1998
    Publication date: February 14, 2002
    Inventors: NAOKI FUKAMI, SEIJI YOSHIMURA, KEISUKE IMAI, KEIJI HEMMI, MITSUE HEMMI, KEIICHIRO HEMMI, YUSUKE HEMMI
  • Patent number: 6339173
    Abstract: The present invention provides novel amide-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a lipophilic moiety; (c) R2, R3, and R4 are positively charged moieties, or at least one but not all of R2,R3, or R4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X− is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R3 or R4 must have an alkyl moiety of at least 10 carbon atoms.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: January 15, 2002
    Assignee: Promega Biosciences, Inc.
    Inventors: David Aaron Schwartz, William J. Daily, Brian Patrick Dwyer, Kumar Srinivasan, Bob Dale Brown
  • Publication number: 20010056116
    Abstract: The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the blood brain barrier. Once in the central nervous system, the prodrug is hydrolyzed into the fatty acid carrier and the drug to release the drug.
    Type: Application
    Filed: July 9, 2001
    Publication date: December 27, 2001
    Inventor: Victor Shashoua
  • Patent number: 6320017
    Abstract: The present invention relates to new polyamide oligomers. These oligomers can be conjugated to lipids, nucleic acids, peptides, proteins, etc. The oligomer-lipid conjugates can be used to form liposomes, virusomes, micelles, etc., optionally containing drugs or biological agents. The polyamide oligomers are heterobifunctional allowing the attachment of other suitable ligand compounds (e.g., a targeting moiety). In addition, methods of use for the liposomes, virusomes, micelles, etc., are provided.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: November 20, 2001
    Assignee: INEX Pharmaceuticals Corp.
    Inventor: Steven Michial Ansell
  • Patent number: 6319952
    Abstract: The present invention provides a family of branched fatty acids and their derivatives, which improve and enable the penetration and absorption of active ingredients through biomembranes, such as blood brain barrier. The invention further provides pharmaceutical compositions comprising these branched fatty acids and methods of using these compositions to permeabilize biological membranes thereby improving the administration of bioactive or therapeutic substances to cells or organs. According to a more preferred embodiment of this invention the methods are particularly useful to treat certain kinds of CNS lesions and diseases including tumors, infections, abscesses and degenerative and behavioral disorders.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: November 20, 2001
    Assignee: D-Pharm Ltd.
    Inventors: Marina Vinikova, Israel Shapiro, Alexander Kozak
  • Patent number: 6310247
    Abstract: Novel trienoic retinoid compounds of with apoptotic activity useful for the prevention and treatment of cancer.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: October 30, 2001
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Adrian Wai-Hing Cheung, Stephen B. Ferguson, Louise Helen Foley, Allen John Lovey
  • Patent number: RE38073
    Abstract: This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: and N-oxides thereof and salts thereof.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: April 8, 2003
    Assignee: Research Corporations Technologies, Inc.
    Inventor: Louis A. Carpino