Nitrogen Bonded Directly To The Metal Patents (Class 556/137)
-
Publication number: 20100197890Abstract: The invention provides polypeptide-platinum conjugates comprising an anti-cancer platinum complex conjugated to polypeptides that bind relatively specifically to cancer cells, so as to direct the conjugates to cancer cells resulting in increased anti-cancer efficacy and decreased side-effects as compared to cisplatin and other conventional anti-cancer platinum complexes.Type: ApplicationFiled: January 29, 2010Publication date: August 5, 2010Inventor: Hugh McTavish
-
Publication number: 20100190180Abstract: The subject invention concerns methods and materials for cancer screening using platinum complexes to detect a STAT protein biomarker. Platinum (IV) complexes interacting with STATs directly correlate with the STAT expression. In one embodiment, fluorescently-labeled and/or antibody-linked platinum (IV) complexes can be used to assess the STAT expression and define malignant potential. Other methods such as imaging (MRI, e.g.) can also be used to assess platinum-STAT interactions. The STAT protein can be, for example, STAT3.Type: ApplicationFiled: July 6, 2006Publication date: July 29, 2010Inventor: Heidi Kay
-
Publication number: 20100184854Abstract: Provided are nitroplatinum(IV) complexes which may be useful treating various forms of proliferative diseases, such as cancer. In some instances the platinum(IV) complexes are relatively stable and may be suitable for oral administration. Also provided are methods of treatment, as well as kits and unit dosages.Type: ApplicationFiled: December 11, 2009Publication date: July 22, 2010Applicant: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus DU PREEZ
-
Patent number: 7759510Abstract: The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.Type: GrantFiled: July 21, 2009Date of Patent: July 20, 2010Assignee: University of South FloridaInventors: Heidi Kay, Jay W. Palmer, Joseph A. Stanko
-
Patent number: 7754899Abstract: This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability, in a high turnover number (TON) and a high enantioselectivity. In the formula (I), Ar is represented by the following formula (VI) or (VII), wherein in the formula (VI), Xs are independently a halogen or a halogenated alkyl group and R1 and R2s are independently hydrogen or an alkyl group or a trialkylsilyl group having a carbon number of 1-4, and in the formula (VII), R3 is a bulky group.Type: GrantFiled: June 16, 2005Date of Patent: July 13, 2010Assignee: Japan Science And Technology AgencyInventors: Tsutomu Katsuki, Kazufumi Omura, Tatsuya Uchida, Ryo Irie
-
Publication number: 20100174102Abstract: The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy.Type: ApplicationFiled: June 8, 2006Publication date: July 8, 2010Inventors: Vladimir Kysilka, Jan Mengler, Petr Kacer, Libor Cerveny
-
Publication number: 20100155590Abstract: The invention relates to a labeled transition metal complex comprising a transition metal atom, a reactive moiety for allowing a chemical or biological entity to become attached to the transition metal atom, an inert tridentate moiety as a stabilizing bridge, and a marker. The invention also relates to a labeled chemical or biological entity comprising a chemical or biological entity which is attached to said labeled transition metal complex, to the use of said complex for creating a defined shift in the molecular mass of said entity in order to facilitate mass spectrometric analysis of said entity, to methods for rendering chemical or biological entities distinguishable by mass spectrometry as well as to methods for mass spectrometric analysis of the chemical or biological entities.Type: ApplicationFiled: December 1, 2005Publication date: June 24, 2010Applicant: Kreatch Biotechnology B.V.Inventors: Marie Lacombe, Franciscus Johannes Opdam, Eduard Gerhard Talman, Jacky Theo Maria Veuskens
-
Publication number: 20100155650Abstract: An amidine-carboxylic acid complex in accordance with an aspect of the invention has an amidine ligand and a carboxylic acid ligand that are coordinated to one metal atom or a plurality of metal atoms of the same element. A multiple-complex-containing compound, i.e. a bridged polynuclear complex, in accordance with the aspect of the invention is formally derived from two or more such amidine-carboxylic acid complexes, linked by a polyvalent carboxylic acid ligand. The bridged polynuclear complex may be used in a production method to support metal (oxide) clusters on a porous support by impregnating these with a solution thereof, followed by drying and firing.Type: ApplicationFiled: June 7, 2007Publication date: June 24, 2010Inventors: Kazushi Mashima, Masato Ohashi, Akihiro Yagyu, Hirohito Hirata
-
Patent number: 7741240Abstract: This invention relates to new transition metal catalyst compounds represented by the formula (I): where: M and M? are, independently, a group 8, 9, 10 or 11 transition metal, preferably Ni, Co, Pd, Cu or Fe; each R group is, independently, is, hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent R groups may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; R? is hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent R groups may join together with R? to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; each X group is, independently, is, hydrogen, a halType: GrantFiled: May 23, 2005Date of Patent: June 22, 2010Assignee: ExxonMobil Chemical Patents Inc.Inventors: Gregory A. Solan, Jeremie D. A. Pellettier
-
Patent number: 7737276Abstract: The present invention relates to a process for preparing highly pure tris-ortho-metalated organometallic compounds and to pure organometallic compounds of this type, especially compounds of the d8 metals, which may find use as coloring components in the near future as active components (=functional materials) in a series of different types of applications which can be classified within the electronics industry in the widest sense.Type: GrantFiled: May 29, 2004Date of Patent: June 15, 2010Assignee: Merck Patent GmbHInventors: Ingrid Bach, Philipp Stössel
-
Patent number: 7737290Abstract: Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) NN?-diispropylacetamidinate vapor and hydrogen gas. Cobalt metal films were deposited on heated substrates be the reaction of alternating doses of cobalt(II) bis(N,N?-diispropylacetamidinate) vapor and hydrogen gas. Nitrides and oxides of these metals can be formed by replacing the hydrogen with ammonia or water vapor, respectively. The films have very uniform thickness and excellent step coverage in narrow holes. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices.Type: GrantFiled: July 1, 2009Date of Patent: June 15, 2010Assignee: President and Fellows of Harvard UniversityInventors: Roy Gerald Gordon, Booyong S. Lim
-
Publication number: 20100141127Abstract: Heteroleptic compounds containing phenylpyridine and phenylbenzimidazole are provided. The compounds may be used in organic light emitting devices, particularly as emissive dopants in the emissive layer of such devices.Type: ApplicationFiled: November 10, 2009Publication date: June 10, 2010Applicant: Universal Display CorporationInventors: Chuanjun XIA, Raymond Kwong, Dinesh Rayabarapu, Bin Ma
-
Patent number: 7723493Abstract: Metal-containing complexes of a tridentate beta-ketoiminate, one embodiment of which is represented by the structure: wherein M is a metal such as calcium, strontium, barium, scandium, yttrium, lanthanum, titanium, zirconium, vanadium, tungsten, manganese, cobalt, iron, nickel, ruthenium, zinc, copper, palladium, platinum, iridium, rhenium, osmium; R1 is selected from the group consisting of alkyl, alkoxyalkyl, fluoroalkyl, cycloaliphatic, and aryl, having 1 to 10 carbon atoms; R2 is selected from the group consisting of hydrogen, alkyl, alkoxy, cycloaliphatic, and aryl; R3 is linear or branched selected from the group consisting of alkyl, alkoxyalkyl, fluoroalkyl, cycloaliphatic, and aryl; R4 is a branched alkylene bridge with at least one chiral center; R5-6 are individually linear or branched selected from the group consisting of alkyl, fluoroalkyl, cycloaliphatic, aryl, and can be connected to form a ring containing carbon, oxygen, or nitrogen atoms; n is an integer equal to the valence of the metalType: GrantFiled: October 3, 2008Date of Patent: May 25, 2010Assignee: Air Products and Chemicals, Inc.Inventors: Xinjian Lei, Daniel P. Spence, Hansong Cheng
-
Publication number: 20100121090Abstract: The present invention is an optically active organic acidate-bridged dinuclear platinum(II) complex represented by the general formula (I): or the general formula (I?): (wherein R1 and R2 are the same or different and each represent a hydrogen atom or an alkyl group, or form an alkylene group by binding to each other at the ends thereof; R3 and R4 are the same or different and each represent a hydrogen atom or an alkyl group, or form an alkylene group by binding to each other at the ends thereof; A represents a single bond or a methylene group; and X? represents an anion). The complex of the present invention has an excellent anticancer activity, and is useful as medicine, especially an anticancer agent.Type: ApplicationFiled: March 27, 2008Publication date: May 13, 2010Inventor: Sumio Kaizaki
-
Publication number: 20100113815Abstract: This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability, in a high turnover number (TON) and a high enantioselectivity. In the formula (I), Ar is represented by the following formula (VI) or (VII), wherein in the formula (VI), Xs are independently a halogen or a halogenated alkyl group and R1 and R2s are independently hydrogen or an alkyl group or a trialkylsilyl group having a carbon number of 1-4, and in the formula (VII), R3 is a bulky group.Type: ApplicationFiled: January 5, 2010Publication date: May 6, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Tsutomu Katsuki, Kazufumi Omura, Tatsuya Uchida, Ryo Irie
-
Patent number: 7704755Abstract: The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit to employ a method according to the invention.Type: GrantFiled: May 28, 2002Date of Patent: April 27, 2010Assignee: Kreatech Biotechnology B.V.Inventors: Eduard Gerhard Talman, Robertus Petrus Maria van Gijlswijk, Robert Jochem Heetebrij, Jacky Theo Maria Veuskens
-
Publication number: 20100092667Abstract: Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) NN?-diispropylacetamidinate vapor and hydrogen gas. Cobalt metal films were deposited on heated substrates b the reaction of alternating doses of cobalt(II) bis(N,N?-diispropylacetamidinate) vapor and hydrogen gas. Nitrides and oxides of these metals can be formed by replacing the hydrogen with ammonia or water vapor, respectively. The films have very uniform thickness and excellent step coverage in narrow holes. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices.Type: ApplicationFiled: July 1, 2009Publication date: April 15, 2010Applicant: President and Fellows of Harvard CollegeInventors: Roy G. Gordon, Booyong S. Lim
-
Patent number: 7692002Abstract: The present invention relates to a metal complex of the general formula M(L)n, wherein each L is independently selected and represents a ligand and at least one L is vitamin B12 (cyanocobalamin) or a derivative thereof bound through the nitrogen atom of its cyanide group to M, which is an element selected from the transition metals, thus, forming a M-NC-[Co] moiety with [Co] representing vitamin B12 without cyanide and wherein n is 1, 2, 3, 4, 5 or 6. The complex can be prepared by mixing a precursor molecule with vitamin B12. The metal complexes can be used for radiodiagnostics, chemotherapy and radionuclide therapy.Type: GrantFiled: January 10, 2005Date of Patent: April 6, 2010Assignee: University of ZurichInventors: Roger Alberto, Susanne Barbara Kunze, Hector Knight Castro, Stefan Mundwiler
-
Patent number: 7691984Abstract: Metal-containing complexes of a tridentate beta-ketoiminate, one embodiment of which is represented by the structure: wherein M is a metal such as calcium, strontium, barium, scandium, yttrium, lanthanum, titanium, zirconium, vanadium, tungsten, manganese, cobalt, iron, nickel, ruthenium, zinc, copper, palladium, platinum, iridium, rhenium, osmium; R1 is selected from the group consisting of alkyl, fluoroalkyl, cycloaliphatic, and aryl, having 1 to 10 carbon atoms; R2 is selected from the group consisting of hydrogen, alkyl, alkoxy, cycloaliphatic, and aryl; R3 is linear or branched selected from the group consisting of alkylene, fluoroalkyl, cycloaliphatic, and aryl; R4 is a branched alkylene bridge with at least one chiral center; R5-6 are individually linear or branched selected from the group consisting of alkyl, fluoroalkyl, cycloaliphatic, aryl, and can be connected to form a ring containing carbon, oxygen, or nitrogen atoms; n is an integer equal to the valence of the metal M.Type: GrantFiled: November 27, 2007Date of Patent: April 6, 2010Assignee: Air Products and Chemicals, Inc.Inventors: Xinjian Lei, Daniel P. Spence, Hansong Cheng
-
Patent number: 7687635Abstract: This invention provides metal complexes being useful as catalyst components in metathesis reactions and in reactions involving the transfer of an atom or group to an ethylenically or acetylenically unsaturated compound or another reactive substrate and, with respect to a sub-class thereof, for the polymerisation of ?-olefins and optionally conjugated dienes, with high activity at moderate tempera-tures. It also provides methods for obtaining polymers with very narrow molecular weight distribution by means of a living reaction. It also provides methods for making said metal complexes and novel intermediates involved in such methods. It further provides derivatives of said metal complexes which are suitable for covalent bonding to a carrier, the product of such covalent bonding being useful as a supported catalyst for heterogeneous catalytic reactions. It also provides a direct one-step synthesis of pyrrole, furan and thiophene compounds from diallyl compounds.Type: GrantFiled: July 19, 2004Date of Patent: March 30, 2010Assignee: Telene S.A.S.Inventors: Francis Walter Cornelius Verpoort, Bob De Clercq
-
Patent number: 7687651Abstract: The invention relates to a method for the preparation of trans- or cis-diammoniumdichlorodihydroxoplatinum(IV) and derivatives thereof. What is suggested is reacting trans- or cis-diammoniumdichloroplatinum(II) with a solution comprising >30% peroxide at temperatures below 30° C. and dissolving the product thus obtained in a mineral acid and subsequently precipitating with an alkaline solution.Type: GrantFiled: October 13, 2004Date of Patent: March 30, 2010Assignee: RIEMSER Arzneimittel AGInventor: Zoser B. Salama
-
Patent number: 7683180Abstract: The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions, and for enantioselective reactions in particular. The synthesis of these complexes and details of their use as catalysts is also provided.Type: GrantFiled: April 16, 2002Date of Patent: March 23, 2010Assignee: California Institute of TechnologyInventors: Robert H. Grubbs, Donald W. Ward, Thomas J. Seiders, Steven D. Goldberg
-
Publication number: 20100047458Abstract: There are provided technologies for adsorbing a catalyst metal selectively to an anionic group such as a carboxyl group, thereby forming a metal film on a nonconductive resin selectively, including a palladium complex represented by the following formula (I): wherein L represents an alkylene group and R represents an amino group or a guanidyl group, or a structural isomer thereof, a processing solution for electroless plating catalyst application containing the complex as an active component, and a method for forming a metal plated film on a nonconductive resin, containing subjecting a nonconductive resin having a surface anionic group to a catalyst adsorbing treatment using the processing solution and then to a reduction treatment, electroless metal plating, and metal electroplating.Type: ApplicationFiled: November 2, 2006Publication date: February 25, 2010Applicant: EBARA-UDYLITE CO., LTD.Inventors: Makoto Kohtoku, Mika Hamada
-
Publication number: 20100016618Abstract: The invention relates to a chiral iridium aqua complex of formula (1): wherein R1 and R2 are the same or different and each is an aryl group optionally having at least one substituent selected from the group consisting of a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a haloalkoxy group having 1 to 6 carbon atoms, a nitro group, a carboxyl group and a cyano group, or the like; and wherein R3 and R4 are the same or different and each is an alkyl group or the like, as well as the use of such a chiral iridium aqua complex for asymmetric transfer hydrogenation.Type: ApplicationFiled: January 29, 2008Publication date: January 21, 2010Applicants: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Erick M. Carreira
-
Patent number: 7638645Abstract: Metal(IV) tetrakis(N,N?-dialkylamidinates) were synthesized and characterized. Exemplary metals include hafnium, zirconium, tantalum, niobium, tungsten, molybdenum, tin and uranium. These compounds are volatile, highly stable thermally, and suitable for vapor deposition of metals and their oxides, nitrides and other compounds.Type: GrantFiled: October 17, 2006Date of Patent: December 29, 2009Assignee: President and Fellows of Harvard UniversityInventors: Roy G. Gordon, Jean-Sebastien Lehn, Huazhi Li
-
Patent number: 7635776Abstract: A ligand represented by the formula (1): R1R2N-Q1-X-Q2-NR3R4??(1) wherein R1, R2, R3 and R4 are each the same or different and represent a group represented by the formula (2): wherein Q3 is an optionally substituted alkylene group, an optionally substituted cycloalkylene group, an optionally substituted arylene group, or an optionally substituted divalent heterocyclic group, R5 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heterocyclic group and R6 is a substituent which may coordinate or bind to a metal atom, or R5 and R6, taken together, may form a ring, Q1 and Q2 are each the same or different and represent an optionally substituted alkylene group or a single bond, and X is a divalent spacer.Type: GrantFiled: February 4, 2004Date of Patent: December 22, 2009Assignee: Takasago International CorporationInventors: Kazushi Mashima, Koji Ohno, Kazuhiko Matsumura
-
Publication number: 20090312417Abstract: The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.Type: ApplicationFiled: June 24, 2009Publication date: December 17, 2009Applicant: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
-
Publication number: 20090299085Abstract: This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, wherein more then 1 g/L of the oxalate salt is soluble in the solvent. The invention also relates to new platinum(II) complexes.Type: ApplicationFiled: July 23, 2009Publication date: December 3, 2009Applicant: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus DU PREEZ
-
Publication number: 20090291208Abstract: Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) NN?-diispropylacetamidinate vapor and hydrogen gas. Cobalt metal films were deposited on heated substrates b the reaction of alternating doses of cobalt(II) bis(N,N?-diispropylacetamidinate) vapor and hydrogen gas. Nitrides and oxides of these metals can be formed by replacing the hydrogen with ammonia or water vapor, respectively. The films have very uniform thickness and excellent step coverage in narrow holes. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices.Type: ApplicationFiled: August 4, 2009Publication date: November 26, 2009Inventors: Roy G. Gordon, Booyong S. Lim
-
Publication number: 20090292134Abstract: An iridium-platinum complex of the following formula: wherein Cp* is a pentamethylcyclopentadienyl ligand or the like, X is a hydrogen atom, or a substituent group such as a bromine atom or an organic group disposed at a position ortho, meta or para to the phenyl group, or at a combination of the positions, and Y is a methyl group or the like.Type: ApplicationFiled: March 7, 2007Publication date: November 26, 2009Inventors: Hiroyuki Matzuzaka, Shin Takemoto, Hirohito Hirata
-
Patent number: 7622590Abstract: Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.Type: GrantFiled: September 9, 1999Date of Patent: November 24, 2009Assignee: University of New Orleans FoundationInventors: Steven P. Nolan, Jinkun Huang
-
Publication number: 20090285884Abstract: The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.Type: ApplicationFiled: July 21, 2009Publication date: November 19, 2009Applicant: University of South FloridaInventors: Heidi Kay, Jay W. Palmer, Joseph A. Stanko
-
Patent number: 7615636Abstract: A ruthenium complex is provided. The ruthenium complex is represented by the following Formula (I): in which, X is a monodentate anion ligand, R1, R2, R4 and R5 are the same or different substituents and represent alkyl, alkoxy, aminoalkyl, haloalkanes or substituted phenyl group, carboxylic acid group or acid radical salt thereof, sulfonic acid group or acid radical salt thereof, phosphoric acid group or acid radical salt thereof or hydrogen atom. R3 represents perhalogenated alkyl group, alkoxy, alkyl, amino, halogens, or hydrogen atom. The ruthenium complexes are suitable for being used as dye-sensitizers for fabricating dye-sensitized solar cells.Type: GrantFiled: November 14, 2007Date of Patent: November 10, 2009Assignee: Industrial Technology Research InstituteInventors: Ching-Yen Wei, Chao-Ining Yu, Fu-Ching Tung, Yun Chi, Hsing-Yi Chen, I-Hui Lin
-
Patent number: 7615659Abstract: The present invention relates to a process for preparing a palladium(0) compound, comprising the reaction of a palladium compound with one or more compounds of the general formula I, II or III in the presence of a base: Term-O—{[Si(R16)(CR19CR17R18)O]v[Si(R20)2O]w}-Term ??(III). The Palladium(0) compounds are suitable as homogeneous catalysts, as a precursor for preparing homogeneous catalysts, as a precursor for preparing homogeneous catalysts in situ or as a precursor for preparing heterogeneous catalysts.Type: GrantFiled: October 30, 2003Date of Patent: November 10, 2009Assignee: Umicore AG & Co. KGInventors: Bernd Kayser, Ralf Karch, Oliver Briel, Ingo Kleinwächter
-
Patent number: 7611733Abstract: Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a first microemulsion by mixing a molten lipid, a surfactant, and optionally a co-surfactant and the platinum compound acqueous solution; b) preparing a solution by mixing a surfactant and optionally a co-surfactant in water, heating to complete solution, preferably at the same melting temperature of the lipid used in a) and adding a co-surfactant; c) dispersing the microemulsion obtained in a) into the solution obtained in b) obtaining a multiple microemulsion c); d) dispersing the microemulsion obtained in c) in aqueous medium at a temperature ranging from 0.5° C. to 4° C.Type: GrantFiled: March 24, 2005Date of Patent: November 3, 2009Assignees: Cell Therapeutics Europe S.r.l., NANOVECTOR S.r.l.Inventors: Maria Rosa Gasco, Paolo Gasco, Alberto Bernareggi
-
Patent number: 7608730Abstract: We disclose here processes for making Platinum complex of general formula (I) where in, the conformation of 1,2-diaminocyclohexane is cis, trans-l or trans-d isomer and R1 and R2 combinedly make dicarboxylic acid having formulae (II), (III) and (IV), here in, the two carboxylic acid groups are on the same or on vicinal carbon atoms, n is zero or an integer ranging from 1 to 5 and R3 is either hydrogen or a substituent with electron withdrawing or electron releasing effects exemplified by alkoxy, halo, and nitro groups by reacting a compound of formula M2PtX4 wherein X represents halogen atom such as Cl or Br or thiocyanate with (i) 1,2-diaminocyclohexane (ii) source of silver ion selected from a silver compound containing divalent anion in presence of a corresponding carboxylic acid of formula (II) or (III) or (IV) to get the compound of formula (I), purifying the said compound by treating with alkali metal iodide and isolating the title compound by any conventional methods.Type: GrantFiled: February 5, 2004Date of Patent: October 27, 2009Assignee: Fresenius Kabi Oncology LimitedInventors: Golak Chandra Maikap, Bhagat Raj, Pradipta Kumar, Kannan Vivekanandan, Chandrakant Belwal
-
Patent number: 7605282Abstract: The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy.Type: GrantFiled: April 9, 2005Date of Patent: October 20, 2009Assignee: Vuab Pharma A.S.Inventors: Vladimir Kysilka, Tomas Kalisz, Petr Kacer
-
Patent number: 7601392Abstract: Provided are an organic-metal precursor material that can be readily decomposed without reacting with an oxidant, a method of manufacturing a metal thin film using the organic-metal precursor material, and a metal thin film prepared using the organic-metal precursor material. The organic-metal precursor material is an organic molecule having lone-pair electrons selected from the group consisting of ether, amine, tetrahydrofuran (THF), a phosphine group, and a phosphite group, and has a structure of covalent coordination bond.Type: GrantFiled: August 31, 2006Date of Patent: October 13, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Jung-hyun Lee, Bum-seok Seo
-
Patent number: 7601796Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.Type: GrantFiled: January 4, 2006Date of Patent: October 13, 2009Assignee: Intezyne Technologies, Inc.Inventors: Kurt Breitenkamp, Kevin Sill
-
Patent number: 7589225Abstract: This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, wherein more than 1 g/L of the oxalate salt is soluble in the solvent. The invention also relates to new platinum(II) complexes.Type: GrantFiled: March 7, 2005Date of Patent: September 15, 2009Assignee: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
-
Patent number: 7589196Abstract: 1,1?-Biphenyl-2,2?-diphosphines having at least one amine substituent in the para position relative to the phosphine group and having the formulae are ligands for metal complexes which serve as catalysts for asymmetric addition reactions of prochiral organic compounds and whose catalytic properties can be tailored specifically to particular substrates by substitution of the amine group.Type: GrantFiled: April 5, 2004Date of Patent: September 15, 2009Assignee: Solvias AGInventors: Benoît Pugin, Pierre Martin, Markus Müller, Frédéric Maurice Naud, Felix Spindler, Marc Thommen, Gianpietro Melone, Martin Kesselgruber
-
Publication number: 20090214626Abstract: The subject invention concerns biotin-conjugated platinum complexes that exhibit direct and indirect (immunological) antitumor cell activity. The subject invention also concerns the biotin-platinum complexes of the invention that have another molecule, such as an antibody, a ligand, a receptor, etc., bound to the biotin moiety. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.Type: ApplicationFiled: November 10, 2005Publication date: August 27, 2009Inventors: Heidi Kay, Valerie L. McDevitt
-
Patent number: 7579373Abstract: Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or spermidine, and the central amines of the polyamine-bridge are chemically bonded to labile blocking groups. The presence of the blocking groups serves to minimize the toxicity of the Pt compounds upon administration. Selective removal of the blocking groups and release of the active, unblocked species occurs upon exposure to suitable environmental conditions.Type: GrantFiled: August 22, 2002Date of Patent: August 25, 2009Assignee: Virginia Commonwealth UniversityInventors: Nicholas Farrell, Alexander Hegmans, John D. Roberts
-
Patent number: 7576126Abstract: The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.Type: GrantFiled: November 24, 2004Date of Patent: August 18, 2009Assignee: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
-
Publication number: 20090199739Abstract: This invention relates to organometallic compounds having the formula (L1)yM(L2)z wherein M is a metal or metalloid, L1 is the same or different and is (i) a substituted or unsubstituted anionic 4 electron donor ligand or (ii) a substituted or unsubstituted anionic 4 electron donor ligand with a pendant neutral 2 electron donor moiety, L2 is the same or different and is (i) a substituted or unsubstituted anionic 2 electron donor ligand or (ii) a substituted or unsubstituted neutral 2 electron donor ligand; y is an integer of 2; and z is an integer of from 0 to 2; and wherein the sum of the oxidation number of M and the electric charges of L1 and L2 is equal to 0; a process for producing the organometallic compounds, and a method for producing a film or coating from the organometallic compounds. The organometallic compounds are useful in semiconductor applications as chemical vapor or atomic layer deposition precursors for film depositions.Type: ApplicationFiled: January 12, 2009Publication date: August 13, 2009Inventors: David M. Thompson, Joan Geary, Adrien R. Lavoie, Juan E. Dominquez
-
Publication number: 20090203928Abstract: This invention relates to organometallic compounds having the formula (L1)yM(L2)z wherein M is a metal or metalloid, L1 is the same or different and is (i) a substituted or unsubstituted anionic 4 electron donor ligand or (ii) a substituted or unsubstituted anionic 4 electron donor ligand with a pendant neutral 2 electron donor moiety, L2 is the same or different and is (i) a substituted or unsubstituted anionic 2 electron donor ligand or (ii) a substituted or unsubstituted neutral 2 electron donor ligand; y is an integer of 2; and z is an integer of from 0 to 2; and wherein the sum of the oxidation number of M and the electric charges of L1 and L2 is equal to 0; a process for producing the organometallic compounds, and a method for producing a film or coating from the organometallic compounds. The organometallic compounds are useful in semiconductor applications as chemical vapor or atomic layer deposition precursors for film depositions.Type: ApplicationFiled: January 12, 2009Publication date: August 13, 2009Inventors: David M. Thompson, Joan Geary, Adrien R. Lavoie, Juan E. Dominquez
-
Patent number: 7569606Abstract: Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L1 and L2 )which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.Type: GrantFiled: April 17, 2006Date of Patent: August 4, 2009Assignee: BioNumerik Pharmaceuticals, Inc.Inventors: Zejun Xiao, Frederick H. Hausheer, Pavankumar Petluru
-
Patent number: 7566798Abstract: The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.Type: GrantFiled: August 13, 2004Date of Patent: July 28, 2009Assignee: University of South FloridaInventors: Heidi Kay, Jay W. Palmer, Joseph A. Stanko
-
Publication number: 20090179552Abstract: A light emitting composition includes a light-emitting lumophore-functionalized nanoparticle, such as an organic-inorganic light-emitting lumophore-functionalized nanoparticle. A light emitting device includes an anode, a cathode, and a layer containing such a light-emitting composition. In an embodiment, the light emitting device can emit white light.Type: ApplicationFiled: November 6, 2008Publication date: July 16, 2009Inventors: JESSE FROEHLICH, HYUN SIK CHAE, AMANE MOCHIZUKI, SHENG LI, GHASSAN JABBOUR
-
Patent number: RE41209Abstract: Platinum complexes of formula Ia or Ib where each A, is a leaving group and may be the same or different, which is suitably halo, especially chloro, hydroxy, carboxylate or together form a bi-dentate carboxylate or sulphate, each B, which may be the same or different, is halo, hydroxy, carboxylate, carbamate or carbonate ester, Z is a substituted amine wherein the substituent sterically hinders access of the Pt atom to a DNA strand of a tumour cell, and X is NH3 or mono- or di-alkyl substituted NH3, are active against cancer cells, and appear to show a unique form of chemical and biological action.Type: GrantFiled: May 8, 2009Date of Patent: April 6, 2010Assignees: Genzyme Corporation, The Institute of Cancer ResearchInventor: Barry Murrer