Abstract: The invention concerns a process for preparing a hybrid organic-inorganic material (HOIM) with phosphorus-containing bridges between the surface of an inorganic substrate containing an element M and one or more organic groups of the covalent M-O-P-R type, said process using, as a precursor for said organic group or groups, at least one organophosphorus acid halide with formula RxP(O)Xy in which x=1 or 2, y=3?x, X being a halogen and R designating at least one organic alkyl, aryl or aryl-alkyl group. Non-exhaustive applications for the hybrid organic-inorganic material obtained by the process of the invention are in the fields of anti-corrosion, lubrication, microelectronics, nanotechnologies, composite materials, heterogeneous catalysis, supported catalysis, depollution and biomedical applications.

Abstract: This invention discloses 2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-19-nor-vitamin D3 and (20R)-25-hydroxy-2-methylene-19-nor-vitamin D3, as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. Although these compounds have relatively low calcemic activities they may also be useful in the treatment of bone diseases due to their ability to act as prodrugs in vivo.

Abstract: The invention pertains to an oligomer or polymer substituted by one or more bisacylphosphine oxide moieties, characterized in that said bisacylphosphine oxide moiety is linked via the phosphorous atom, optionally via a spacer group, to the oligomer or polymer backbone; as well as to specifically functionalized bisacylphosphine oxides, suitable to prepare said polymers or oligomers.

Abstract: The present invention is directed to a method of exchanging nanostructures from within aqueous liquid media into organic liquid media. The steps comprise first supplying solid nanostructures in an aqueous liquid media, adjusting the pH, incorporating an ionic surfactant sufficient to reduce nanostructure aggregation, followed by concentrating the nanostructures in the aqueous liquid media. The nanostructures may them be placed in organic liquid media followed by introduction of a coupling agent capable of covalent attachment to the nanostructure surface while providing a functional group capable of polymerization to covalently bond the nanostructures to a selected monomer and/or polymer resin.

Abstract: Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.

Abstract: There are provided an ion-conducting microparticle including an ion-dissociative group and exhibiting an affinity for a fluorine-containing resin, and a method of manufacturing the same, an ion-conducting composite including the ion-conducting microparticle, a membrane electrode assembly (MEA) including the ion-conducting composite as an electrolyte, and an electrochemical device such as a fuel cell.

Abstract: An ionic liquid that is a salt has a Formula: Such ionic liquids may be used in electrolytes and in electrochemical cells.

Abstract: The present invention relates to new hybrid, organic-inorganic hybrid silicates and metal-silicates characterized by a crystalline structure containing structural units having formula (a), wherein R is an organic group possibly containing one or more element T selected from Group IIIB, IVB, VB and from transition metals. A process starting from cyclic trisilanes for the preparation of said materials, is also described. These materials can be used as molecular sieves, adsorbents, in the field of catalysis, in the field of electronics, in the field of sensors, in the area of nanotechnology.

Abstract: A phosphazene-supported catalyst in which a support is bonded to a group represented by the general formula (1): wherein n, Zn?, a, b, c, d, R, R1 and D are all defined. The phosphazene-supported catalyst is highly effective to catalyze various organic reactions, and further has no reduction of activity even after recovery and reuse of the catalyst, thus it being economically advantageous. In addition, the polymerization of cyclic monomers, substitution of substituents, carbon-carbon bond forming reactions and the like can be conducted with extremely high efficiency.

Abstract: In one aspect, the present invention provides a protected ligand precursor having structure XX wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence a protecting group is selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, and C2-C30 aromatic radicals.

Abstract: In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions. Also provided are a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement agent I.

Abstract: A phosphorylcholine group-containing chemical compound represented by the following formula (1). In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group. R is one of the structures in the following formulas (2)-(4) (the chemical compound of formula (1) in the structures of the following formulas (2)-(4) is expressed as A-R—B). In formulas (2)-(4), L is 1-6, P is 1-3. Also a surface modifier consisting of the aforementioned phosphorylcholine group-containing chemical compound, modified powder treated with said surface modifier, a chromatography packing consisting of a modified carrier treated with said surface modifier, a filter treated with said surface modifier, and a glass device treated with said surface modifier.

Abstract: The invention relates to bis(perfluoroalkyl)phosphinous acids, bis(perfluoroalkyl)thiophosphinous acids and derivatives, the synthesis thereof and the use thereof, in particular for the synthesis of air-stable metal complexes for catalytic processes.

Abstract: The object of the present invention is to provide a packing material and a separation method that manifest excellent hydrophilic interactions. The present invention provides a packing material for hydrophilic interaction chromatography consisting of a modified support treated with the surface modifier represented by the following formula (6) or (7). (In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group.

Abstract: This invention discloses 1-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-1-desoxy-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.

Abstract: A phosphorus-containing silsesquioxane is represented by the formula [R13SiO1/2]m[R2SiO3/2]n[R3SiO3/2]p[(R4O)2PO(CH2)xSiO3/2]q wherein each of R1, R2, R3, and R4 independently represents a hydrocarbyl group; x represents an integer of from 1 to 8; m is a positive number less than 1.5; n and q are positive numbers greater than 0 and less than 1; and p is a number greater than or equal to 0 and less than 1. Further, (n+p)/q is in a range of from 0.5 to 99, and (n+p+q)=1. Curable and cured compositions comprising the phosphorus-containing silsesquioxane are disclosed.

Abstract: The present invention relates to a process for preparing pentanoic diacid derivatives useful for preparing pyrimidine derivatives, in particular as intermediates useful for preparing pyrimidine derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, such as HMG-CoA reductase inhibitors, e.g. rosuvastatin.

Abstract: A phosphorylcholine group-containing chemical compound represented by the following formula (1). In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group. R is one of the structures in the following formulas (2)-(4) (the chemical compound of formula (1) in the structures of the following formulas (2)-(4) is expressed as A-R—B). In formulas (2)-(4), L is 1-6, P is 1-3. Also a surface modifier consisting of the aforementioned phosphorylcholine group-containing chemical compound, modified powder treated with said surface modifier, a chromatography packing consisting of a modified carrier treated with said surface modifier, a filter treated with said surface modifier, and a glass device treated with said surface modifier.

Abstract: A process comprises (a) combining (1) at least one metal cation source, (2) at least one phosphate anion source, (3) at least one organic base comprising at least one organic moiety comprising at least about five carbon atoms, and (4) at least one organosilane comprising at least one organic moiety comprising at least about six carbon atoms; and (b) allowing the metal cation source and the phosphate anion source to react in the presence of the organic base and the organosilane (for example, to form surface-modified metal phosphate nanoparticles).

Abstract: Disclosed herein is an radioisotope adsorbent including a bifunctional organosilane compound, including an organosiloxane functional group and a phosphate group, bonded on the surface of silica which is a bone structure of the adsorbent, and a method of preparing the radioisotope adsorbent, and a strontium/yttrium generator using the radioisotope adsorbent. Since the radioisotope adsorbent has a high adsorption capacity for 90Y such as 95% extraction efficiency or more from ICi 90Sr/90Y by using a column packed with 0.4 g of the adsorbent with a high-purity of 90Y, it can be usefully to be employed in the fields requiring 90Y.

Abstract: A method for synthesizing a phosphonic acid functionalized mesoporous metal oxide material (e.g., silica, titania, alumina, preferably silica material) is provided. Further, a method of using the phosphonic acid functionalized mesoporous silica material as a solid acid catalyst in a pinicole-pinacolone rearrangement reaction, and a method of using a phosphonic acid functionalized mesoporous silica material as a solid acid catalyst in a transesterification reaction is provided. A method for preparing a mesoporous titania film for use in a dye sensitized solar cell is also provided.

Abstract: The present invention relates to a zwitterionic stationary phase comprising a carrier and at least one zwitterionic ligand bound to said carrier, said phase being suitable for HPLC separation in Hydrophilic Interaction mode, wherein the positively charged part of said zwitterionic ligand is located at the end of the ligand, and the negatively charged part of said zwitterionic ligand is located between the positively charged part and the part of said zwitterionic ligand directly binding to said carrier, or a polymeric backbone attached to the carrier, wherein the intramolecular distance between the negatively charged part of the zwitterionic ligand preferably is at most 10 atoms long. The invention also provides methods for producing said zwitterionic stationary phase and method for using the phase in HPLC separations.

Abstract: The invention relates to novel acidic siloxane derivatives, the use, methods of use or processes making use of siloxane derivatives of this type, especially to achieve an anti-microbial, preservative and/or antiadhesive effect, for the protection of articles and/or materials, and a process for the manufacture of the novel compounds. The siloxane acids (which may also be in salt form) have the formula (I), formula (II) and/or formula (III), wherein the symbols have the meanings given in the specification.

Abstract: At least one (poly)thio alkoxy and/or halosilane is/are prepared by reaction of at least one sulfur-containing reagent with at least one alkoxy and/or halosilane, wherein an ionic addition of a sulfur-containing reagent to an alkoxy and/or halosilane is preferably conducted with thermal and/or actinic activation; the novel polythio alkoxy and/or halosilanes of formula (III.2) thus prepared are particularly useful as coupling agents in elastomeric compositions containing a white filler of the silica type and having the formula (III.2) wherein, for example, R1.1 and R1.3=methyl and R1.2=ethoxy.

Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain hydrophilic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerizable hydrophilic siloxanyl monomers.

Abstract: The invention relates to new compounds of the formula, wherein R and R1 are each independently hydrogen, a linear or branched C1-40 alkyl, C2-40 alkenyl or C2-40 alkynyl group, an aryl or C1-40 alkylaryl group or an optionally complex metal ion Mn+/n wherein n is an integer from 1 to 8; the free valences of the silicate oxygen atoms are saturated by one or more of: silicon atoms of other groups of the formula, hydrogen, a linear or branched C1-12 alkyl group or by cross-linking bridge members R3qM1(OR2)mOk/2 or Al(OR2)3-pOp/2 or R3 Al(OR?)2-1 O1/2; wherein M1 is Si or Ti; R2 is linear or branched C1-12 alkyl group; and R3 is alinear or branched C1-6 alkyl group; k is an integer from 1 to 4 and q and m are integers from 0 to 2; such that M+k+q=4; and p is an integer from 1 to 3; and r is an integer from 1 to 2; or other known oxo metal bridging systems; x, y and z are integers such that the radio of x:y+z, varies from 0.

Abstract: A phosphorus-containing silsesquioxane is represented by the formula [R13SiO1/2]m[R2SiO3/2]n[R3SiO3/2]p[(R4O)2PO(CH2)xSiO3/2]q wherein each of R1, R2, R3, and R4 independently represents a hydrocarbyl group; x represents an integer of from 1 to 8; m is a positive number less than 1.5; n and q are positive numbers greater than 0 and less than 1; and p is a number greater than or equal to 0 and less than 1. Further, (n+p)/q is in a range of from 0.5 to 99, and (n+p+q)=1. Curable and cured compositions comprising the phosphorus-containing silsesquioxane are disclosed.

Abstract: Novel cyclic and acyclic oxazaphospholanes are described, as well as their use in the synthesis of sphingomyelin and sphingomyelin analogous. The production of synthetic sphingomyelins is also described. 2S, 3R stereoisomers of oxazaphospholanes and sphingomyelins, and synthetic methods for their preparation are described.

Abstract: The invention concerns a process for preparing a hybrid organic-inorganic material (HOIM) with phosphorus-containing bridges between the surface of an inorganic substrate containing an element M and one or more organic groups of the covalent M-O-P-R type, said process using, as a precursor for said organic group or groups, at least one organophosphorus acid halide with formula RxP(O)Xy in which x=1 or 2, y=3?x, X being a halogen and R designating at least one organic alkyl, aryl or aryl-alkyl group. Non-exhaustive applications for the hybrid organic-inorganic material obtained by the process of the invention are in the fields of anti-corrosion, lubrication, microelectronics, nanotechnologies, composite materials, heterogeneous catalysis, supported catalysis, depollution and biomedical applications.

Abstract: Disclosed are electrolytes that are organosilicon phosphorus-based, and supercapacitors which incorporate them. These electrolytes are cationic salts with a phosphorous containing organosilicon moiety. They appear particularly suitable for use in applications such as electric and hybrid electric vehicles.

Abstract: The invention relates to chemical genera of organometal benzenephosphonates useful in cross-coupling organic synthesis, having general formula: where R is selected from boron, zinc, tin and silicon residues.

Abstract: A quaternary onium aromatic sulfonate represented by the formula: wherein each R1 independently comprises substituted or unsubstituted, aliphatic or aromatic, hydrocarbyl, carbocyclic or heterocyclic radicals, each X is selected from the group consisting of phosphorus and nitrogen; wherein “a” has a value of 0, 1 or 2, and “b” has a value of 0 or 1 with the proviso that (a+b) is equal to 1 or 2; G1 is an aromatic group; E comprises a bis(carbonyloxyalkyl) polydiorganosiloxane, a bis(carbonyloxyaryl) polydiorganosiloxane, and an ether linkage; each Y1 independently comprises hydrogen, a monovalent hydrocarbon group, alkenyl, allyl, halogen, bromine, chlorine; nitro; and OR, wherein R is a monovalent hydrocarbon group; “q” represents any integer from and including zero through the number of positions on G1 available for substitution; “t” represents an integer equal to at least one; “s” represents an integer equal to either zero or one; and “u” represents any integer including zero; with the proviso that whe

Abstract: Autocatalyzed, thermally curable compositions free from external catalysts and comprising condensates of silanes which contain at least one of hydrolyzable atoms and hydrolyzable groups and processes for preparing them, and their use for producing thermally cured compositions.

Abstract: The present invention relates to a curing accelerating compound-silica composite material capable of giving excellent storage stability to a curable resin composition, which is obtained by subjecting one or more compounds selected from compounds represented by the general formula (I-1) below and partial condensates thereof to a sol-gel reaction in the presence of a curing accelerating compound and water; a curable resin composition comprising the same; and an electronic component device comprising a device sealed with the curable resin composition.

Abstract: The invention relates to novel silane compounds corresponding to the formula (I) below: A-E-X??(I) in which: X represents a silyl group capable of creating a covalent bond after reaction with the hydroxyl or hydride functional groups of a support; E represents an organic spacer group; A represents a group chosen from the groups of formulae below: in which: Z1 to Z5 independently represent a hydrogen atom or a halogen atom; Z6 and Z7 represent a group for protecting the phosphonic acid functional group, a hydrogen atom or a monovalent cation; Z8 to Z12 independently represent a group for protecting the carboxylic acid functional group, a hydrogen atom or a monovalent cation; and Z13 represents an imidazole, N-hydroxysuccinimide, nitrophenyl, pentafluorophenyl or acid anhydride group. Use of these silane compounds for functionalizing solid supports and for immobilizing biological molecules on these supports.

Abstract: The invention relates to compounds of formula (I) (XaRbSi)m[(B) ([O]oP[O]pR?cYd)n]4-a-b (I), where the groups, residues and indices have the following meanings: B=an at least doubly-valent straight chained or branched group with at least one organic polymerizable group and at least three carbon atoms, X=a group which may be cleaved from the silicon atom by hydrolysis, R=optionally substituted alkyl, alkanyl, aryl, alkylaryl or arylalkyl, R??R, Y?Cl, OH or OR?, R??H, alkyl or aryl, a=0, 1, 2 or 3, b=0, 1 or 2, a+b together=1, 2 or 3, c=0, 1 or 2, d=0, 1 or 2, c+d together=2, m=at least 1, with the proviso that m is not greater than 1 when a+b=1 or 2, n=at least 1, o=0 or 1 and p=0 or 1. The invention further relates to a series of methods by which the above compounds may be produced.

Abstract: Provided is an organosilane compound expressed by any one of the following general formulae (1) to (7): (wherein: Ar represents a phenylene group or the like; R1 represents a hydrogen atom or the like; R2 to R8 each represent a methyl group or the like; n represents an integer in a range from 0 to 2; m represents an integer of 1 or 2; L represents a single bond or the like; X represents a hydrogen atom or the like; and Y represents a hydrogen atom or the like).

Abstract: A phosphorylcholine group-containing chemical compound represented by the following formula (1). In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group. R is one of the structures in the following formulas (2)-(4) (the chemical compound of formula (1) in the structures of the following formulas (2)-(4) is expressed as A-R—B). In formulas (2)-(4), L is 1-6, P is 1-3. Also a surface modifier consisting of the aforementioned phosphorylcholine group-containing chemical compound, modified powder treated with said surface modifier, a chromatography packing consisting of a modified carrier treated with said surface modifier, a filter treated with said surface modifier, and a glass device treated with said surface modifier.

Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain hydrophilic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerized hydrophilic siloxanyl monomers.

Abstract: The present invention provides a novel phosphorus-containing organosilicon compound furnished with performance of an oxaphosphorin compound, a method for producing therefore and a resin composition containing the same, particularly a polyester or polycarbonate resin composition and a coating composition containing the same, characterized by that said phosphorus-containing organosilicon compound has in the molecule a phosphorus-containing group (an X group) bonded to a silicon atom and represented by the following chemical formula (1)

Abstract: A silicon containing adduct having the formula (I) wherein X is an electron withdrawing group selected from the group consisting of carbonyl and sulphone groups, sulphonium and phosphonium salts; R is selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, alkaryl, aralkyl, alkoxyaryl, alkoxyalkyl, oligoalkoxyalkyl, di-alkylaminoalkyl, N-aryl-N-alky-laminoalkyl, hydroxyalkoxy, alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, cycloalkenyloxy, cycloalkynyloxy, aralkoxy, alkoxyaryloxy, alkoxyalkoxy, oligoalkoxyalkoxy, di-alkylaminoalkoxy, N-aryl-N-alkylamino-alkoxy, acyloxy, acyloxyalkyl, N-diacyl-iminoalkyl groups, organosilane, organosiloxane, hydroxyaryl, hydroxyalkenyl, hydroxyalkynyl and hydroxy groups and any of the above groups substituted with one or more hydroxyl or xzwitterionic group Z, or R—X— is a nitrile group; R3 and R4 are individually selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl,

Abstract: A composition including nanoparticles each having an acidic polymerizable siloxane moiety. For example, a hydrolysis stable, self-etching, self-priming dental adhesive composition including 90 to 10 percent by weight of an aqueous phase, and 10 to 90 percent by weight of acidic polymerizable nanoparticles. The acidic polymerizable nanoparticles are obtainable by hydrolysis of a mixture containing one or more hydrolyzable organosilicon compounds wherein (i) at least a portion of the hydrolyzable organosilicon compounds contains one or more polymerizable groups and (ii) at least a portion of the hydrolyzable organosilicon compounds contain one or more acidic moieties.

Abstract: Compounds of the formula I (I), in which Ar is a group or unsubstituted or substituted cyclopentyl, cyclohexyl, naphthyl, biphenylyl or an O-, S- or N-containing 5- or 6-membered heterocyclic ring; R1 and R2 are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 are hydrogen, C1-C20alkyl, OR11 or halogen; R6 is unsubstituted or substituted C1-C24alkyl, C2-C24alkyl, which is interrupted by O, S or NR14 and is unsubstituted or substituted; C2-C24alkenyl, uninterrupted or interrupted by O, S or NR14 and unsubstituted or substituted; unsubstituted or substituted C7-C24arylalkyl; C4-C24cycloalkyl, uninterrupted or interrupted by O, S and/or NR14; or C8-C24arylcycloalkyl; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O or S and unsubstituted or substituted; R12 and R13 are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O atoms and unsubstituted or substituted; or R12 and R13 together are C3-C5alkylene, uninterrupted or interrupted by

Abstract: The present invention relates to a series of novel silicone alkoxylated esters which have terminal carboxyl groups that form salt complexes with certain amid containing cationic compounds to form very mild conditioning products suited for personal care applications like shampoos, body wash, hand wash and bath products.

Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

Abstract: Method is provided for selectively opening rings of polyhedral oligomeric silsesquioxane (POSS) compounds to from functionalized derivatives thereof or new POSS species. Per the inventive method, the POSS compound is reacted with an acid to selectively cleave bonds in the POSS rings to add functionalities thereto for grafting, polymerization or catalysis, to thus form new familes of POSS derived compounds. Also provided are the new compounds so formed. Method is also provided for expanding rings of POSS compounds. Per the inventive method, a POSS compound is reacted with silane reagents to obtain an expanded POSS framework with added Si ring substituends to form new families of POSS compounds. Also provided are the new compounds so formed.

Abstract: The invention relates to compounds of formula (I) (XaRbSi)m[(B) ([O]oP[O]pR′cYd)n]4-a-b (I), where the groups, residues and indices have the following meanings: B=an at least doubly-valent straight chained or branched group with at least one organic polymerisable group and at least three carbon atoms, X=a group which may be cleaved from the silicon atom by hydrolysis, R=optionally substituted alkyl, alkanyl, aryl, alkylaryl or arylalkyl, R′═R, Y═Cl, OH or OR′, R″═H, alkyl or aryl, a=0, 1, 2 or 3, b=0, 1 or 2, a+b together=1, 2 or 3, c=0, 1 or 2, d=0, 1 or 2, c+d together=2, m=at least 1, with the proviso that m is not greater than 1 when a+b=1 or 2, n=at least 1, o=0 or 1 and p=0 or 1. The invention further relates to a series of methods by which the above compounds may be produced.

Abstract: There are disclosed amphoteric nano-sized metal oxide particles functionalized with silyl esters of a phosphonate and composites thereof with an acrylate-based monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Also disclosed are the method making such functionalized particular by reacting a metal oxide with a silyl ester of a phosphonate in the presence of a non-aqueous solvent and in an inert atmosphere and the method of making the composites wherein the functionalized particles are admixed with an acrylate-based matrix monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Further disclosed is the method of dental repair wherein the composites are applied to a tooth and photopolymerized.

Abstract: The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.