Carbonyl Attached Directly Or Indirectly To Silicon By Nonionic Bonding Patents (Class 556/436)
- Silicon and the carbon of the -COO- group are bonded directly to the same hydrocarbon group (Class 556/438)
- Silicon and the oxy of the -COO- group are bonded directly to the same hydrocarbon group (Class 556/440)
- Carbocyclic ring having silicon as part of one substituent and the -COO- as part of another substituent (Class 556/441)
- Silicon is bonded directly to the oxy of the -COO- group (Class 556/442)
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Patent number: 5597938Abstract: A novel process for the production of a compound represented by the formula: ##STR1## wherein Z and Z' each represents a protective group for the hydroxyl group; R.sup.1 represents a hydrogen atom or an alkyl group; R.sup.2 represents an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a group represented by the formula --B--D (in which B is an alkylene group and D is a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenoxy group or a cycloalkyl group), a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenoxy group; R.sup.3 and R.sup.4 each represents a hydrogen atom, an alkyl group or an alkoxy group; R.sup.5 represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a cyano group, an amino group, a hydroxyl group or a group represented by a formula --COOR.sup.8 ; R.sup.6 represents a group represented by a formula --COOR.sup.9, a cyano group, a hydroxyl group, a group represented by a formula --OCOR.sup.Type: GrantFiled: August 10, 1995Date of Patent: January 28, 1997Assignees: Taisho Pharmaceutical Co., Ltd., Fumie SatoInventor: Fumie Sato
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Patent number: 5583195Abstract: Epoxysilicone polymers partially or completely functionalized by a fluorescent, photo-sensitizing, or simultaneously fluorescing and photo-sensitizing substituent bonded to the silicone polymer by means of a carbon oxygen carbon bond provide fluorescent dye marking compounds for silicone compositions that are particularly useful in determining the quality of release coatings made therewith.Type: GrantFiled: September 29, 1995Date of Patent: December 10, 1996Assignee: General Electric CompanyInventor: Richard P. Eckberg
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Patent number: 5554780Abstract: The present invention relates to a novel process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones which are useful for the treatment of Alzheimer's disease and senile dementia as disclosed by Schirlin, et al. in European Patent Application Publication No. 0 409 676, published Jan. 23, 1991.Type: GrantFiled: February 1, 1995Date of Patent: September 10, 1996Assignee: Merrell Pharmaceuticals Inc.Inventor: Richard A. Wolf
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Patent number: 5554317Abstract: A compound having an unsaturated side chain represented by the formula: ##STR1## in which A and B are the same and different and represent an aromatic or heterocyclic group or either one of A and B represents a single bond; X.sub.1, X.sub.2 and X.sub.3 are the same or different and represent a hydrogen atom or a lower alkyl group; R.sub.1 represents a saturated or unsaturated alkyl group which may be substituted with a halogen atom or an alkoxyalkyl group which may be substituted with a halogen atom; X represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.ident.C-- or a single bond; n is an integer of 0 to 6; q is an integer of 1 to 15; p and s are each 0 or 1; and the asterisk * indicates an asymmetric carbon atom, which is useful as an intermediate of a liquid crystal or a monomer of a liquid crystalline polymer.Type: GrantFiled: July 13, 1994Date of Patent: September 10, 1996Assignee: Sumitomo Chemical Company, LimitedInventors: Yoshiaki Tsubata, Kayoko Ueda, Koichi Fujisawa, Takayuki Higashii, Masayoshi Minai, Naoyuki Takano, Yukari Fujimoto
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Silanes, process for their preparation and their application to prepare polymers and polycondensates
Patent number: 5532398Abstract: Silanes of the general formula (I):{X.sub.a R.sub.b Si(R'(A).sub.c).sub.(4-a-b) }.sub.x B (I)in which the groups and indices have the following meaning:X: hydrogen, halogen, hydroxy, alkoxy, acyloxy, alkyl carbonyl, alkoxycaryl or --NR".sub.2 ;R: alkyl, alkenyl, aryl, alkaryl, or aralkyl;R': alkylene, arylene or alkylene arylene;R": hydrogen, alkyl or aryl;A: O, S, PR", POR", NHC(O)O or NHC(O)NR";B: straight chain or branched organic group, which is derived from a B' compound with at least one C.dbd.C double bond for c.dbd.1 and A.dbd.NHC(O)O or NHC(O)NR") or at least two C.dbd.C double bonds, and 5 to 50 carbon atoms;a: 1, 2 or 3;b: 0, 1 or 2;c: 0 or 1;x: whole number, whose maximum value corresponds to the number of double bonds in compound B' minus 1, or is equal to the number of double bonds in compound B', when c.dbd.Type: GrantFiled: December 29, 1994Date of Patent: July 2, 1996Assignee: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.Inventors: Herbert Wolter, Klaus Rose, Christian Egger -
Patent number: 5523442Abstract: Fluorinated silylated aromatic compounds, their intermediates, methods of use in treating diseases associated with deficiencies of cholinergic transmission in the central nervous system and methods for their preparation are disclosed.Type: GrantFiled: July 18, 1995Date of Patent: June 4, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Jean-Noel Collard, Jean-Marie Hornsperger
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Patent number: 5514825Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 10 carbons; R.sub.2 and R.sub.3 are hydrogen, or alkyl of 1 to 6 carbons and the substituted ethynyl group occupies either the 2 or the 3 position of the tetrahydronaphthalene nucleus; m is an integer having the value of 0-3; o is an integer having the value 0-4; Y is a phenyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, and imidazolyl, said groups being optionally substituted with one or two R.sub.2 groups; A is (CH.sub.2).sub.n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.Type: GrantFiled: December 29, 1994Date of Patent: May 7, 1996Assignee: Allergan, Inc.Inventors: Vidyasagar Vuligonda, Min Teng, Richard L. Beard, Alan T. Johnson, Tien T. Duong, Yuan Lin, Roshantha A. Chandraratna
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Patent number: 5504255Abstract: The present invention provides special epoxy derivative (1), cyclohexanone derivative (2), cyclohexenone derivative (3) and 3-substituted cyclohexenone derivative (4) which are useful as intermediates for synthesizing physiologically active materials, and a method for stereoselectively introducing substituted groups. Further, the present invention provides a method for synthesizing optically active compounds, such as optically active carvone via these intermediates.Type: GrantFiled: May 15, 1995Date of Patent: April 2, 1996Assignee: Chisso CorporationInventors: Seiichi Takano, Kunio Ogasawara
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Patent number: 5492939Abstract: Silicone surfactants having a siloxane backbone and polyether pendants having average atomic masses of 2250. The surfactants of the invention operate in polyurethane foam compositions to provide stable foams over a range of surfactant concentrations while still producing product foams without splits. Also disclosed and claimed are polyurethane foam compositions which include the surfactants, a method of making polyurethane foam using the surfactants, and polyurethane foam made by the method.Type: GrantFiled: April 12, 1995Date of Patent: February 20, 1996Assignee: Dow Corning CorporationInventors: Michael A. Stanga, John H. Frey, Robert F. Hoffman, Robert E. Stevens
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Patent number: 5484950Abstract: A process for the selective monoadditon of an olefin or acetylene to a siloxane which contains two reactive Si--H bonds to produce a product in which only one of the two Si--H functions has added across the olefin or acetylene is disclosed. A process for making unsymmetrical siloxanes from symmetrical dihydrosiloxanes and products of both of these processes are also disclosed. Products are represented by the formula I in which R.sup.1 and R.sup.Type: GrantFiled: December 21, 1992Date of Patent: January 16, 1996Assignee: Polyset Company, Inc.Inventor: James V. Crivello
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Patent number: 5464922Abstract: There is disclosed a novel organopolysiloxane-grafted polybenzobisoxazole and a method for preparing the functional organopolysiloxane-grafted polybenzobisoxazoles using a phthaloyl halide-functional organopolysiloxane.Type: GrantFiled: August 24, 1994Date of Patent: November 7, 1995Assignee: Dow Corning Asia Ltd.Inventors: Maki Itoh, Akihito Sakakibara
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Patent number: 5449801Abstract: A process for the selective high yield halogenation R--CH.sub.3 wherein R is ##STR1## Si(Cl).sub.m (CH.sub.3).sub.n, wherein m is 1 to 3, n is 1 to 3 and m+n is 3; phenyl; or phenyl substituted with Cl, Br, F, OR.sup.1, SR.sup.1 or NO.sub.2 ; R.sup.1 is C.sub.1 -C.sub.3 alkyl; and X is chlorine or bromine; under reactive distillation conditions which continuously and selectively separate the mono, di, or trihalogenated product from the reaction zone and which does not require recycling of the starting materials is disclosed.Type: GrantFiled: July 14, 1993Date of Patent: September 12, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: Chris S. Barnum, Charles T. Blaisdell
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Patent number: 5446182Abstract: A method for the removal and concentration of desired ions such as Pd(II), Ru(III), Pd(IV), Au(III), Au(I), Ag(I), and Hg(II) from a multiple ion source solution which may contain larger concentrations of other undesired ions including H.sup.+ comprises bringing the source solution into contact with a compound comprising a sulfur and electron withdrawing group containing ligand covalently bonded through an organic spacer silicon grouping to a solid inorganic support. The sulfur and electron withdrawing group containing ligand portion(s) of the compound has an affinity for the desired ions to form a complex thereby removing the desired ions from the source solution. The desired ions are removed from the compound by contacting the compound with a much smaller volume of a receiving solution having a greater affinity for the desired ions than does the sulfur and electron withdrawing group containing ligand portion of the compound.Type: GrantFiled: February 15, 1994Date of Patent: August 29, 1995Assignee: Brigham Young UniversityInventors: Ronald L. Bruening, Bryon J. Tarbet, Reed M. Izatt, Jerald S. Bradshaw
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Patent number: 5437816Abstract: A high polymer comprising a recurring unit represented by the formula: ##STR1## wherein r and p each represent an integer of 2 to 5, q represents a number of 4 to 20, m represents an integer of 8 to 12, a represents an integer of 1 to 8, and * represents an asymmetric carbon, and a ferroelectric liquid crystal composition comprising the high polymer and a low molecular weight smectic liquid crystal are disclosed.Type: GrantFiled: November 16, 1992Date of Patent: August 1, 1995Assignee: Idemitsu Kosan Co., Ltd.Inventors: Hiroyuki Endo, Fumio Moriwaki, Satoshi Hachiya
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Patent number: 5426206Abstract: Methods are provided for preparing all four diastereomers of 2-alkyl-3-hydroxyalkanals, 2-alkyl-3-silyloxyalkanals, and the like, with high enantiocontrol, using non-aldol chemistry. The synthetic methods also provide novel, stereospecific routes to polypropinates and chiral 2-substituted-1,3 diols.Type: GrantFiled: November 24, 1993Date of Patent: June 20, 1995Assignee: The Regents of the University of CaliforniaInventors: Michael E. Jung, Derin C. D'Amico
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Patent number: 5405598Abstract: Compounds of formula I and II ##STR1## in which B contains a carboranyl group and one of R.sub.3 and R.sub.4 is a carboranyl group or a boronic acid or ester are useful sensitizing agents for boron neutron capture therapy.Type: GrantFiled: February 24, 1992Date of Patent: April 11, 1995Inventors: Raymond F. Schinazi, Dennis C. Liotta
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Silanes, process for their preparation and their application to prepare polymers and polycondensates
Patent number: 5399738Abstract: Silanes of the general formula (I):{(X.sub.a R.sub.b Si(R'(A).sub.c).sub.(4-a-b) }.sub.x B (I)in which the groups and indices have the following meaning:X: hydrogen, halogen, hydroxy, alkoxy, acyloxy, alkyl carbonyl, alkoxycaryl or --NR".sub.2 ;R: alkyl, alkenyl, aryl, alkaryl, or aralkyl;R': alkylene, arylene or alkylene arylene;R": hydrogen, alkyl or aryl;A: O, S, PR", POR", NHC(O)O or NHC(O)NR";B: straight chain or branched organic group, which is derived from a B' compound with at least one C.dbd.C double bond for c=1 and A=NHC(O)O or NHC(O)NR") or at least two C.dbd.C double bonds, and 5 to 50 carbon atoms;a: 1, 2 or 3;b: 0, 1 or 2;c: 0 or 1;x: whole number, whose maximum value corresponds to the number of double bonds in compound B' minus 1, or is equal to the number of double bonds in compound B', when c=1 and A stands for NHC(O)O or NHC(O)NR";are suitable to prepare homo and copolycondensates and homo or copolymers according to the sol-gel method or by photochemical or thermal polymerization.Type: GrantFiled: April 5, 1991Date of Patent: March 21, 1995Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.Inventors: Herbert Wolter, Klaus Rose, Christian Egger -
Patent number: 5391795Abstract: Novel silylated agents capable of absorbing ultraviolet light are incorporated into silicone hardcoats and used to coat polycarbonate substrates. The coated polycarbonate substrates display improved resistances to abrasion and ultraviolet light.Type: GrantFiled: February 18, 1994Date of Patent: February 21, 1995Assignee: General Electric CompanyInventor: James E. Pickett
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Patent number: 5380900Abstract: Disclosed herein is an .alpha.-methylene-cyclopentanone derivative represented by the formula [I] below which is useful as an intermediate for pharmaceuticals and insecticides, especially prostaglandins. Also disclosed herein is a process for producing the derivative advantageously on an industrial scale. ##STR1## where X denotes (.alpha.-OZ, .beta.-H) or (.alpha.-H, .beta.-OZ), with Z representing a protecting group for the hydroxyl group; U denotes (.alpha.-H, .beta.-R.sup.1) or (.beta.-R.sup.1, .alpha.-H); R.sup.1 denotes ##STR2## where R.sup.2 denotes a protected hydroxyl group, a substituted or unsubstituted C.sub.1-15 alkyl group, a substituted or unsubstituted C.sub.2-15 alkenyl group, a substituted or unsubstituted C.sub.2-15 alkynyl group, or a substituted or unsubstituted C.sub.6-15 aryl group; Z' denotes a protecting group for the hydroxyl group; and k is 0 or 1).Type: GrantFiled: February 12, 1992Date of Patent: January 10, 1995Assignee: Nissan Chemical Industries, LimitedInventors: Fumie Sato, Kazutaka Arai, Katsuaki Miyaji
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Patent number: 5359110Abstract: A process for the preparation of R.alpha.-cyclopentenoids and then R.alpha., R.omega.-cyclopentanoids is described. The process involves the reaction of a compound of the formula ##STR1## where X is halo, particularly Br or I and P is a protecting group with an alkylborane to produce the R.alpha.-cyclopentenone. The R.alpha.-cyclopentenone is reacted with a R.omega. cuprate to produce the R.alpha., R.omega.-cyclopentenoid. The process is used for the preparation of prostaglandins which are known pharmaceutically active compounds.Type: GrantFiled: November 16, 1993Date of Patent: October 25, 1994Assignee: Board of Governors of Wayne State UniversityInventors: Carl R. Johnson, Matthew P. Braun
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Patent number: 5359101Abstract: Anionically polymerizable monomers containing at least one silicon or titanium atom form polymeric photoresists having good dry etch resistance for use in microlithography. The monomers are of the formula ##STR1## wherein A is --H or --CH.dbd.CH.sub.2 ; X is a strong electron withdrawing group;Y is a strong electron withdrawing group containing at least one silicon or titanium atom.Preferably Y is ##STR2## wherein n is 1-5 and R.sup.2, R.sup.3 and R.sup.4 are C.sub.1 -C.sub.10 alkyl. A particularly preferred monomer is 3-trimethylsilylpropyl 2-cyanoacrylate.Methods for applying a resist coating by vapor deposition of these monomers and exposure to radiation are described. A positive or negative tone image can be produced, depending upon the imaging method employed. The imaging layer may be applied over a planarizing layer to form a multilayer photoresist.Type: GrantFiled: October 1, 1991Date of Patent: October 25, 1994Assignee: Loctite Ireland, Ltd.Inventors: John Woods, Pauline Coakley
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Patent number: 5352822Abstract: The present invention discloses pesticidally active compounds of formula (II) ##STR1## or a salt thereof, wherein Q is an monocyclic aromatic ring, or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of which one may be nitrogen and the rest carbon each ring system being optionally substituted, or Q is a dihalovinyl group or a group R.sup.6 --C.tbd.C-- where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halogen or hydrogen; R.sup.2, R.sup.3 , R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 haloalkyl; and R.sup.1 is selected from hydrogen and C.sub.1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C.sub.1-6 alkoxy and X.sup.1 is hydrogen, fluoro or chloro.Type: GrantFiled: April 7, 1993Date of Patent: October 4, 1994Assignee: Roussel UclafInventors: Robert J. Blade, George S. Cockerill, John E. Robinson
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Patent number: 5348684Abstract: The novel silylalkyl or silylalkenyl compounds correspond to the general formula (I) ##STR1## Here the symbols A.sup.1, A.sup.2, A.sup.3 denote aromatic or heteroaromatic molecular units such as 1,4-phenylene or pyrimidine-2,5-diyl which are combined via a single bond (for k, m=0) or via functional groups M.sup.1,M.sup.2 such as CO--O or CH.sub.2 --O; j, k, l, m, n are zero or 1 (j+l+n=2 or 3). The radicals R.sup.2, R.sup.3, R.sup.4, R.sup.5 are hydrogen or alkyl/alkenyl, cycloalkyl, and the radicals R.sup.6, R.sup.7, R.sup.8 have a comparable meaning (hydrogen); R.sup.1 is alkyl/alkenyl or one of the substituents known from LC chemistry such as an .alpha.-haloalkanoic radical. In some cases compounds have wide and polymorphous liquid crystalline phases.Type: GrantFiled: August 20, 1992Date of Patent: September 20, 1994Assignee: Hoechst AktiengesellschaftInventors: Wolfgang Hemmerling, Hans-Rolf Dubal, Claus Escher, Gerhard Illian, Yoshio Inoguchi, Ingrid Muller, Mikio Murakami, Dieter Ohlendorf, Rainer Wingen
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Patent number: 5329023Abstract: The invention relates to a method of preparing optically active alcohols which consist substantially (at least 75% e.e.) or entirely of one enantiomer of formula 4 ##STR1## wherein R and A are as defined therein. The method comprises, which maintaining enantiomeric excess, converting an optically active cyanohydrin of formula 1 ##STR2## into optically active protected cyanohydrin of formula 2 ##STR3## converting the protected cyanohydrin of formula 2 into an optically active compound of formula 3 ##STR4## removing the protecting group B.Type: GrantFiled: June 15, 1992Date of Patent: July 12, 1994Assignee: Duphar International Research B.V.Inventors: Johannes Brussee, Arne Van Der Gen
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Patent number: 5322557Abstract: A primer composition comprising (A) a fluorinated alkoxysilane containing an epoxy group, (B) an organic titanium or aluminum compound, and (C) a solvent is effective in bonding fluorinated organic polymers to metal and glass members.Type: GrantFiled: December 22, 1992Date of Patent: June 21, 1994Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Hiroshi Inomata, Yasuo Tarumi, Kazuhiko Tomaru
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Patent number: 5302737Abstract: This invention provides a process to regioselectively silylcarbonylate 1-alkynes and in predominantly the Z-isomer with substantial absence of hydrosilylation by-products. The process involves reacting a 1-alkyne with an organosilane and carbon monoxide in a solvent in the presence of a catalyst. The catalyst is a carboxylate salt of a metal such as rhodium, iridium or rhenium.Type: GrantFiled: December 23, 1992Date of Patent: April 12, 1994Assignee: Trinity UniversityInventors: Michael P. Doyle, Michael S. Shanklin
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Patent number: 5300375Abstract: This invention is directed to a novel acrylic alkoxy substituted silane and to a single phase solid solvent-containing electrolyte having recurring units derived from such silane incorporated within the solid polymeric matrix of the solid electrolyte. A novel electrolytic cell that incorporates the subject electrolyte also is provided. The specific molecular structure exhibited by such solid polymeric matrix is believed to advantageously facilitate the positioning of an inorganic ion salt and solvent between adjacent polymeric molecules during service within the solid electrolyte.Type: GrantFiled: April 19, 1993Date of Patent: April 5, 1994Assignee: Valence Technology, Inc.Inventor: Benjamin Chaloner-Gill
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Patent number: 5300613Abstract: Fluorine-containing organosilicon compounds having the following general formula:CH.sub.2 .dbd.CHCH.sub.2 NHCO--[Rf--CONH(CH.sub.2).sub.3 --Q--(CH.sub.2).sub.3 NHCO].sub.a --Rf--CONHCH.sub.2 CH .dbd.CH.sub.2wherein a is an integer of 1 or above, Rf is a divalent perfluoropolyether group, and Rf is a divalent cyclosiloxane group containing an unsubstituted or substituted monovalent hydrocarbon group without an aliphatically unsaturated bond. The compounds are of use as a starting material in synthesizing rubbers or mold release agents which are high in such properties as solvent resistance, chemical resistance and the like.Type: GrantFiled: June 1, 1993Date of Patent: April 5, 1994Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Hirofumi Kishita, Shinichi Sato, Takashi Matsuda
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Patent number: 5294501Abstract: This invention is directed to a novel silane acrylate and to a single phase solid solvent-containing electrolyte having recurring units derived from the silane acrylate incorporated within the solid polymeric matrix of such solid electrolyte. A novel electrolytic cell that incorporates the subject electrolyte also is provided. The specific molecular structure exhibited by such solid polymeric matrix is believed to advantageously facilitate the positioning of an inorganic ion salt and solvent between adjacent polymeric molecules during service within the solid electrolyte.Type: GrantFiled: April 19, 1993Date of Patent: March 15, 1994Assignee: Valence Technology, Inc.Inventor: Benjamin Chaloner-Gill
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Patent number: 5283349Abstract: A 2,6,7-trisubstituted-3-methylenebicyclo-[3.3.0]octane of formula (I) or an enantiomer thereof, or a mixture of these in an arbitrary ratio. The compound is a key intermediate for preparation of isocarbacyclins which are useful as medicines for the circulatory system such as an antithrombotic agent, an antilipidemic agent, a hypotensive agent or an antiarterosclerotic agent.Type: GrantFiled: September 11, 1986Date of Patent: February 1, 1994Assignee: Teijin LimitedInventors: Toshio Tanaka, Kiyoshi Bannai, Seizi Kurozumi
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Patent number: 5270426Abstract: This invention discloses a novel organosilicon compound, which is soluble in silicone oils and strongly absorbs ultraviolet light, represented by the general formula:An organosilicon compound having a benzophenone skeleton represented by the general formula: ##STR1## where "n" is an integer in the range 0.about.100, R.sup.1 are similar or dissimilar saturated hydrocarbon groups with a number of carbon atoms in the range 1-30 or phenyl group, R.sup.2 is a monofunctional organic group represented by the formula --(CR.sup.3 .sub.2 CR.sup.3 (H) CR.sup.3 .sub.2)-- R.sup.4, R.sup.3 is hydrogen atom or a saturated monofunctional hydrocarbon group with 1-5 carbon atoms, and R.sup.4 is a group represented by the formula: ##STR2## wherein R.sup.5 is a hydrogen atom or hydroxyl group, R.sup.6 are hydrogen atoms, or similar or dissimilar monofunctional saturated or unsaturated hydrocarbon groups with 1-10 carbon atoms, "a" is an integer in the range 0-3, and "b" is an integer in the range 0-4.Type: GrantFiled: December 7, 1992Date of Patent: December 14, 1993Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Koji Sakuta, Satoshi Kuwata
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Patent number: 5254708Abstract: The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.Type: GrantFiled: December 14, 1990Date of Patent: October 19, 1993Assignee: Nissan Chemical Industries, Ltd.Inventors: Fumie Sato, Kazutaka Arai, Katsuaki Miyaji
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Patent number: 5254542Abstract: Novel organic silicon compounds having a UV absorbing benzotriazole or benzophenone skeleton are provided comprising R.sup.1.sub.3 SiO.sub.1/2 and SiO.sub.2 units as essential units, 0 to 20 mol % of R.sup.2 SiO.sub.3/2 and R.sup.3.sub.2 SiO units, and 0 to 20 mol % of R.sup.3.sub.2 SiO units. The siloxane units are present in a molar ratio: (R.sup.1.sub.3 SiO.sub.1/2 +R.sup.2 SiO.sub.3/2 +R.sup.3.sub.2 SiO)/SiO.sub.2 of from 0.5 to 1.5. At least one group of formulae (1) through (7) constitutes 1 to 33 mol % of the total quantity of the organic groups represented by R.sup.1, R.sup.2 and R.sup.3 while the remainder is a monovalent saturated or unsaturated organic group or groups having 1 to 18 carbon atoms. Cosmetic compositions containing the same compounds have improved UV absorbing capacity.Type: GrantFiled: September 25, 1991Date of Patent: October 19, 1993Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Koji Sakuta, Satoshi Kuwata
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Patent number: 5232915Abstract: 9.alpha.-Hydroxy-19,11.beta.-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R.sup.1, R.sup.2, G, Z, R.sup.4 --Y and R.sup.4' --Y' follows from the description. The steroids of general formula I have antigestagen and/or antiglucocorticoidal action and can be used for the production of pharmaceutical agents.Type: GrantFiled: January 14, 1992Date of Patent: August 3, 1993Assignee: Schering AktiengesellschaftInventors: Eckhard Ottow, Gunter Neef, Rudolf Wiechert, Walter Elger, Sybille Beier, Karl-Heinrich Fritzemeier
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Patent number: 5233076Abstract: A novel process and intermediates are disclosed for the preparation of the optically active compound ##STR1## wherein R.sup.3 is a protecting group. This cyclobutanone compound is used to prepare a compound of the formula ##STR2## having anti-viral activity.Type: GrantFiled: April 29, 1991Date of Patent: August 3, 1993Assignee: E. R. Squibb & Sons, Inc.Inventor: Saleem Ahmad
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Patent number: 5231208Abstract: The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.Type: GrantFiled: December 14, 1990Date of Patent: July 27, 1993Assignee: Nissan Chemical Industries, Ltd.Inventors: Fumie Sato, Kazutaka Arai, Katsuaki Miyaji
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Patent number: 5231206Abstract: Cyclic organosiloxanes which contain at least one Si-bonded organic radical and have at least one donor/acceptor .pi.-electron system.Type: GrantFiled: November 23, 1990Date of Patent: July 27, 1993Assignee: Consortium fur elektrochemische Industrie GmbHInventors: Peter Spes, Mechthild HeBling, Franz-Heinrich Kreuzer
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Patent number: 5227505Abstract: The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.Type: GrantFiled: December 14, 1990Date of Patent: July 13, 1993Assignee: Nissan Chemical Industries, Ltd.Inventors: Fumie Sato, Kazutaka Arai, Katsuaki Miyaji
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Patent number: 5225583Abstract: Alkyl-aryl 1,3-propanedione silicone derivative characterized in that said derivative is siloxane having at least one unit expressed by the general formula 1 as shown below and other unit which can exist in said siloxane is expressed by a general formula of O.sub.4-r/2 SiR.sup.5.sub.r, and an external preparation for skin with said derivative compounded therein. ##STR1## Herein; R.sup.1 : A hydroxyl group, an alkyl group having 1 to 8 carbon atoms, or an alkoxy group having 1 to 8 carbon atomsR.sup.2 : An alkyl group having 1 to 7 carbon atomsR.sup.3 : A bivalent alkylene group or an oxyalkylene group having at least 2 carbon atomsR.sup.4, R.sup.5 : An alkyl group, a phenyl group, or a trimethylsiloxy group having 1 to 4 carbon atomsm: An integer from 0 to 3p: 0 or 1q,r: An integer from 0 to 3.)An excellent UV-A absorbing capability and compatibility with a silicone-based base are provided.Type: GrantFiled: August 13, 1992Date of Patent: July 6, 1993Assignee: Shiseido Co., Ltd.Inventors: Tomomi Okazaki, Kenichi Umishio, Keiichi Uehara
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Patent number: 5210247Abstract: The present invention relates to compounds of the formula ##STR1## in which Y represents an organosilicon radical;R" represents a divalent radical which connects the radical Y to the benzene ring via a chain of at least three atoms;X represents a radical of the formula --COOH, --CN, --CHO, --NH.sub.2 or --OH, in which it is possible to block the hydroxyl group with a protecting group;Z represents the same or different substituents in the 2-, 3-, 5- or 6-position to the radical X, preferably hydrogen or halogen atoms; andp represents a value of 0 to 4;and the use of these and related compounds in the preparation of compounds having liquid-crystalline properties.Type: GrantFiled: October 22, 1990Date of Patent: May 11, 1993Assignee: Consortium fur elektrochemische Industrie GmbHInventors: Norman Haberle, Wolfgang Haas, Leonhard Brader, Franz-Heinrich Kreuzer
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Patent number: 5206230Abstract: Fluorine-containing vitamin D.sub.3 analogues of the formula[I]: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen atom, a chemically inactive hydroxy-protecting group, an acyl having 2 to 8 carbon atoms, or an alkyl having 1 to 8 carbon atoms, X is a straight carbon chain having 4 to 6 carbon atoms which contains at least one double or triple bond, which have excellent vitamin D.sub.3 -like activities, particularly anti-tumor activity owing to differentiation-inducing activity and are useful for the prophylaxis and treatment of various tumors, and intermediates therefor.Type: GrantFiled: June 5, 1991Date of Patent: April 27, 1993Assignee: Daikin Industries, Ltd.Inventors: Nobuo Ikekawa, Yoshiro Kobayashi, Takeo Taguchi, Yoko Tanaka, Yutaka Ohira
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Patent number: 5202459Abstract: The present invention relates to a process for producing cyclobutane derivatives represented by general formula (28): ##STR1## (wherein R represents a substituent; R.sub.2 represents an electron attracting group and Nu represents a substituent corresponding to nucleophilic reagent), by reacting a compound represented by general formula (27): ##STR2## (wherein R has the same significance as defined above and R.sub.1 represents an electron attracting group) with nucleophilic reagents Nu.sup..crclbar. in a solvent.The compounds of formula (28) are useful as intermediates for synthesis of, for example, 9-[2,3-bis(hydroxymethyl)cyclobutan-1-yl]guanine which is expected to be useful as an antiviral agent.Type: GrantFiled: October 16, 1990Date of Patent: April 13, 1993Assignee: Nippon Kayaku Kabushiki KaishaInventors: Chikara Kaneko, Nobuya Katagiri
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Patent number: 5187192Abstract: Compounds of the structure ##STR1## where M is a pharmaceutically acceptable cation or a metabolically cleavable group, R is alkyl, cycloalkyl or --NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted alkyl, cycloalkyl, carbocyclic aryl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.Type: GrantFiled: March 13, 1992Date of Patent: February 16, 1993Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, Karen E. Rodriques
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Patent number: 5185459Abstract: Cyclobutanols of the formula ##STR1## wherein P is a hydroxy protecting group are useful intermediates in the preparation of antiviral compounds.Type: GrantFiled: May 26, 1992Date of Patent: February 9, 1993Assignee: E. R. Squibb & Sons Inc.Inventors: William A. Slusarchyk, Robert Zahler
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Patent number: 5180844Abstract: The present invention provides an optically active 2-methylenecyclopentanone derivative represented by the general formula ##STR1## (wherein R.sup.1 is a protective group for hydroxyl, and the symbol * represents an asymmetric carbon atom).Type: GrantFiled: July 9, 1991Date of Patent: January 19, 1993Assignee: Daiso Co., Ltd.Inventors: Takashi Takahashi, Yoshikazu Takehira
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Patent number: 5159095Abstract: Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing substituted alcohols include hydrosilation of a vinylic ester, especially vinyl acetate, followed by hydrolysis in mild base. The silyl alcohols are useful in preparing phosphorylating reagents for phosphorylating an oligonucleotide. The phosphorylated intermediate bearing the silyl group may be separated from failure product on the basis of bulky substituents on the silyl protecting group, which is later removed, e.g. by fluoride ion.Type: GrantFiled: June 7, 1991Date of Patent: October 27, 1992Assignee: Abbott LaboratoriesInventor: Joseph E. Celebuski
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Patent number: 5149846Abstract: The invention is directed to deuterated vitamin D analogs, and processes and intermediates for their preparation. The end products, that is the deuterated vitamin D analogs, are useful for the treatment osteoporosis and cutaneous inflammations such as psoriasis, and contact dermatitis.Type: GrantFiled: November 16, 1989Date of Patent: September 22, 1992Assignee: Hoffmann-La Roche Inc.Inventors: Enrico G. Baggiolini, Bernard M. Hennessy, Milan R. Uskokovic
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Patent number: 5138010Abstract: New ferroelectric liquid crystal (FLC) materials comprising linear and cyclic polysiloxanes are described. The FLCs exhibit high polarization and fast switching speeds. The disclosed polysiloxanes are derivitized with mesogenic groups which induce high polarization, specifically chiral nonracemic epoxide mesogens, having phenylbenzoate, reverse phenylbenzoate and biphenyl cores. These epoxy polysiloxanes are chemically stable over extended periods. Further, the epoxides can be crosslinked to produce FLC elastomers and like materials having optoelectronic applications. It was found that in the pure polysiloxanes, the smectic layers align along the rubbing direction of an anisotropic surface on contact with that surface.Type: GrantFiled: June 25, 1990Date of Patent: August 11, 1992Assignee: University of Colorado Foundation, Inc.Inventors: Patrick J. Keller, David M. Walba
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Patent number: 5136066Abstract: The present invention provides a process for preparing an optically active cyclopentenone derivative represented by the formula ##STR1## by oxidizing an optically active cyclopentanone derivative represented by the formula ##STR2## with an oxidizing agent, and subsequently subjecting the oxidized compound to an elimination reaction. (In the above formulae, R.sup.1 is a protective group for hydroxyl, R.sup.5 is straight-chain or branched alkyl, alkenyl, alkynyl or alkylaryl having 5 to 22 carbon atoms and containing or not containing oxygen, sulfur or silicon, R.sup.6 is alkyl, aryl or heterocyclic group having or not having a substituent, Z is selenium or sulfur, and the symbol * represents an asymmetic carbon atom.Type: GrantFiled: July 9, 1991Date of Patent: August 4, 1992Assignee: Daiso Co., Ltd.Inventors: Takashi Takahashi, Yoshikazu Takehira
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Patent number: 5136067Abstract: There is disclosed an organopolysiloxane having a molecular weight of 200 to 100,000 which contains at least one silicon-bonded, chloroformyl group-containing organic group, said organopolysiloxane being prepared by reacting (I) the corresponding organopolysiloxane which contains at least one silicon-bonded, triorganosiloxycarbonyl group-containing organic group; and (II) an inorganic halide, such as thionyl chloride. By virtue of its highly reactive chloroformyl group, the organopolysiloxane of the invention find utility as modifiers for polyamide resins, polyester resins, and the like.Type: GrantFiled: January 22, 1991Date of Patent: August 4, 1992Assignee: Dow Corning Toray Silicone, Ltd.Inventor: Tadashi Okawa