Benzene Ring Attached Indirectly To Boron By Nonionic Bonding Patents (Class 558/294)
  • Patent number: 9353133
    Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 31, 2016
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Tsutomu Akama, Michael Richard Kevin Alley, Stephen J. Benkovic, Michael DiPierro, Vincent S. Hernandez, Karin M. Hold, Isaac Kennedy, Igor Likhotvorik, Weimin Mao, Kirk Maples, Jacob J. Plattner, Fernando Rock, Virginia Sanders, Aaron M. Stemphoski, George Petros Yiannikouros, Siead Zegar, Yong-Kang Zhang, Huchen Zhou
  • Patent number: 8722917
    Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: May 13, 2014
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Tsutomu Akama, Michael Richard Kevin Alley, Stephen J. Benkovic, Michael Dipierro, Vincent S. Hernandez, Karin M. Hold, Isaac Kennedy, Igor Likhotvorik, Weimin Mao, Kirk Maples, Jacob J. Plattner, Fernando Rock, Virginia Sanders, Aaron M. Stemphoski, George Petros Yiannikouros, Siead Zagar, Yong-Kang Zhang, Huchen Zhou
  • Publication number: 20120289686
    Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
    Type: Application
    Filed: January 23, 2012
    Publication date: November 15, 2012
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Tsutomu Akama, Michael Richard Kevin Alley, Stephen J. Benkovic, Michael DiPierro, Vincent S. Hernandez, Karin M. Hold, Isaac Kennedy, Igor Likhotvorik, Weimin Mao, Kirk R. Maples, Jacob J. Plattner, Fernando Rock, Virginia Sanders, Aaron M. Stemphoski, George Petros Yiannikouros, Siead Zagar, Yong-Kang Zhang, Huchen Zhou
  • Publication number: 20120289733
    Abstract: Borates, compositions comprising chiral (cyclic and acyclic) and achiral (cyclic and acyclic) borates; chiral (cyclic and acyclic) and achiral (cyclic and acyclic) biborates; and methods for their synthesis. Additionally, a significantly improved synthetic protocol for the synthesis of wide range of boronates starting from borates or biborates and Grignard or organolithium reagents that can be used for kilo lab and commercial scale production.
    Type: Application
    Filed: May 11, 2012
    Publication date: November 15, 2012
    Applicant: Anderson Development Company
    Inventors: Glenn L. HEISE, Malgorzata Myslinska
  • Patent number: 6352798
    Abstract: Novel fluorinated boronate-based compounds which act as anion receptors in non-aqueous battery electrolytes are provided. When added to non-aqueous battery electrolytes, the fluorinated boronate-based compounds of the invention enhance ionic conductivity and cation transference number of non-aqueous electrolytes. The fluorinated boronate-based anion receptors include different fluorinated alkyl and aryl groups.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: March 5, 2002
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Hung Sui Lee, Xiao-Qing Yang, James McBreen, Xuehui Sun
  • Publication number: 20010056202
    Abstract: A method is provided for making substantially ether-free alkali metal tetrakis(pentafluorophenyl) borate salts from tetrakis(pentafluorophenyl) borate magnesium bromide and converting the alkali metal tetrakis(pentafluorophenyl) borate salts to essentially ether-free trityl tetrakis(pentafluorophenyl) borate.
    Type: Application
    Filed: May 18, 2001
    Publication date: December 27, 2001
    Inventor: Michael Van Der Puy
  • Patent number: 6235222
    Abstract: In order to provide a method of safely, efficiently, and industrially manufacturing fluoroaryl magnesium halide containing no impurities, such as coloring components, by a relatively gradual reaction compared with the conventional reactions, and a method of readily and efficiently manufacturing a highly-pure fluoroaryl borane derivative, fluoroaryl magnesium halide expressed by General Formula (1): where each of R1-R5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at least three of R1-R5 are fluorine atoms, and Xa represents Cl, Br, or I; is manufactured by reacting, in a solvent containing a chain ether solvent, hydrocarbon magnesium halide expressed by General Formula (2): R6MgXa  (2) where R6 represents a hydrocarbon group, and Xa represents Cl, Br, or I; with fluoroaryl halide expressed by General Formula (3): where each of R1-R5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: May 22, 2001
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hitoshi Mitsui, Toshiya Iida, Ikuyo Ikeno, Naoko Hirano, Yukiko Ariyoshi
  • Patent number: 6022643
    Abstract: Novel fluorinated boron-based compounds which act as anion receptors in non-aqueous battery electrolytes are provided. When added to non-aqueous battery electrolytes, the fluorinated boron-based compounds of the invention enhance ionic conductivity and cation transference number of non-aqueous electrolytes. The fluorinated boron-based anion receptors include borane and borate compounds bearing different fluorinated alkyl and aryl groups.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: February 8, 2000
    Assignee: Brookhaven Science Associates
    Inventors: Hung Sui Lee, Xia-Oing Yang, James McBreen, Caili Xiang
  • Patent number: 5560853
    Abstract: A borate ester having the formula ##STR1## wherein Y is N, S or O, X is O or S, R.sup.1 and R.sup.2 are, independent of one another, selected from the group consisting of H, (C.sub.1 -C.sub.40)hydrocarbon residues and (C.sub.3 -C.sub.50)cycloalkyl, aryl and aralkyl, each of which may further contain N, O or S, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are independent of one another, selected from the group consisting of H and (C.sub.1 -C.sub.8)hydrocarbon residues, n is 0 to 4. An anti-wear/anti-oxidant/anti-friction/anti-rust additive comprises the borate ester of the invention when added to a lubricating oil.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: October 1, 1996
    Assignee: Pennzoil Products Company
    Inventor: I-Ching Chiu
  • Patent number: 5221758
    Abstract: A method of preparing a compound or formulation having biocidal or preservative properties, or both comprises reacting an organic complexing agent, preferably a selected organic alcohol, with a borate or boric acid to produce a borate organic complex ion. The complex ion is preferably further reacted with a suitable cationic species. A compound or formulation so prepared is also claimed.
    Type: Grant
    Filed: September 28, 1989
    Date of Patent: June 22, 1993
    Inventor: Nigel P. Maynard
  • Patent number: 5169547
    Abstract: Borated or partially borated, amine-contained hindered phenols provide effective antioxidant properties to compositions comprising lubricants and liquid fuels.
    Type: Grant
    Filed: September 29, 1988
    Date of Patent: December 8, 1992
    Assignee: Mobil Oil Corporation
    Inventors: Liehpao O. Farng, Andrew G. Horodysky
  • Patent number: 5006270
    Abstract: Mixed resorcinol-hydroxyester borates have been found to be effective multifunctional additives when incorporated into various lubricating media.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: April 9, 1991
    Assignee: Mobil Oil Corporation
    Inventors: Liehpao O. Farng, Andrew G. Horodysky
  • Patent number: 4985157
    Abstract: Mixed alkoxylated alcohol-hydroquinone or alkoxylated alcohol-resorcinol borates are effective multifunctional antioxidants for lubricants.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: January 15, 1991
    Assignee: Mobil Oil Corporation
    Inventors: Liehpao O. Farng, Andrew G. Horodysky, Robert E. Ernhoffer, John A. Keller, Jr.
  • Patent number: 4985156
    Abstract: A borated reaction product that is useful as a dispersancy enhancing lubricant additive. The product is produced from the maleic anhydride adduct of an olefinic alpha-olefin oligomer. The oligomer (HVI-PAO) comprises the product of the oligomerization of C.sub.2 to C.sub.24 alpha-olefin using a reduced valence state Group VIB metal as the oligomerization catalyst. This adduct of maleic anhydride and HVI-PAO is reacted with a secondary amine such as diphenylamine, an alkanol amine such as triethanolamine, and a borating agent such as boric acid or a borate ester.
    Type: Grant
    Filed: October 24, 1989
    Date of Patent: January 15, 1991
    Assignee: Mobil Oil Corporation
    Inventors: Henry Ashjian, Henry A. Gawel
  • Patent number: 4828740
    Abstract: Mixed hydroquinones-hydroxyester borates have been found to be effective multifunctional additives when incorporated into various lubricating media.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: May 9, 1989
    Assignee: Mobil Oil Corporation
    Inventors: Liehpao O. Farng, Andrew G. Horodysky
  • Patent number: 4724099
    Abstract: A boron-containing heterocyclic compound prepared by reacting a primary amine or ammonia with an alkylene oxide or epoxide and then reacting concurrently or subsequently this reaction intermediate with a boric acid. This boron-containing heterocyclic compound may further be reacted with a metal, metaloid or other metal compound and even further contain sulfur, such as a sulfide group.The boron-containing heterocyclic compound provides extreme pressure anti-wear properties when provided in a lubricating composition. The lubricating composition may also comprise anti-oxidants, copper corrosion inhibitors, and lead corrosion inhibitors. The anti-wear properties of a lubricating composition can be enhanced using the borates of the present invention in conjunction with a copper compound.The boron-containing heterocyclic compound may be used in automatic transmission fluids alone, further reacted with an ester of a polyhydric alcohol or mixed with said ester.Automatic transmission fluid compositions are provided.
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: February 9, 1988
    Assignee: Union Oil Company of California
    Inventors: Richard A. Holstedt, Michael C. Croudace
  • Patent number: 4701274
    Abstract: A lubricating composition having extreme pressure anti-wear properties comprises a lubricating oil and a trisubstituted-borate prepared by sulfurizing the reaction product of a boron compound, a phenol compound, and either a mono-functional compound or dihydroxy functional compound free of nitrogen.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: October 20, 1987
    Assignee: Union Oil Company of California
    Inventors: Michael C. Croudace, Leah T. Mendelson, Richard A. Holstedt
  • Patent number: 4698169
    Abstract: Products made by reacting (i) an alkenylsuccinic compound with (ii) an arylamine and (iii) an alkanolamine, an aminomethane or a hindered alcohol and borated reaction products thereof which provide superior dispersant and antioxidant activity to lubricant compositions when incorporated therein.
    Type: Grant
    Filed: May 1, 1986
    Date of Patent: October 6, 1987
    Assignee: Mobil Oil Corporation
    Inventors: Harry J. Andress, Jr., Henry Ashjian
  • Patent number: 4629578
    Abstract: Lubricating oils containing borated alkyl catechols-succinimide complex are effective in reducing fuel consumption in an internal combustion engine.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: December 16, 1986
    Assignee: Chevron Research Company
    Inventor: Thomas V. Liston
  • Patent number: RE37133
    Abstract: A method of preparing a compound or formulation having biocidal or preservative properties, or both comprises reacting an organic complexing agent, preferably a selected organic alcohol, with a borate or boric acid to produce a borate organic complex ion. The complex ion is preferably further reacted with a suitable cationic species. A compound or formulation so prepared is also claimed.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: April 10, 2001
    Assignee: Fernz Timber Protection Limited
    Inventor: Nigel P. Maynard