Benzene Ring Attached Indirectly To The Cyano Group By Acyclic Nonionic Bonding Patents (Class 558/388)
  • Patent number: 10343972
    Abstract: A fullerene derivative of the present invention has a fullerene skeleton and a plurality of perfluoropolyether chains in a molecule, wherein the perfluoropolyether chains are bonded to the fullerene skeleton via methano groups, and a lubricant and fluororesin composition of the present invention contain the derivative.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 9, 2019
    Assignees: SHOWA DENKO K.K., MITSUBISHI CORPORATION
    Inventors: Takeshi Igarashi, Kentaro Watanabe
  • Patent number: 10343993
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: July 9, 2019
    Assignee: Pliva Hrvatska d.o.o.
    Inventors: Tomislav Biljan, Jasna Dogan, Leonid Metsger, Sara Morasi Pipercic, Marina Ratkaj, Maja Matanovic Skugor, Yi Wang
  • Patent number: 9682924
    Abstract: The present invention relates to a compound of formula (I) in crystalline form, wherein said compound is in the form of the free base or a pharmaceutically acceptable salt thereof, or a solvate of the free base or salt form thereof. The invention also relates to a pharmaceutical composition containing said crystalline form as an active ingredient, and use thereof in the prevention or treatment of disease. The invention further relates to a process for preparing the crystalline form.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: June 20, 2017
    Assignee: CANBEX THERAPEUTICS LIMITED
    Inventor: David Selwood
  • Patent number: 9672857
    Abstract: A lubricant for a magnetic recording medium of the present invention includes an organic compound having a fullerene skeleton, and the organic compound having the fullerene skeleton is expressed by the following general formula (i).
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: June 6, 2017
    Assignee: SHOWA DENKO K.K.
    Inventors: Kenzo Hanawa, Tsubasa Okada
  • Publication number: 20140314699
    Abstract: The present invention concerns a compound of formula wherein R represents a hydrogen atom or a C1-2 alkyl or alkoxyl group; each R1, R2 or R3 represents a hydrogen atom or a methyl or ethyl group; and X represents a CHO, COOR4 or CN group, R4 being a methyl or ethyl group; and at least one of said R, R1 or R2 represents a group containing at least one carbon atom; and it use as perfuming ingredient, for instance to impart odor notes of the floral and/or anis type.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Applicant: FIRMENICH SA
    Inventor: Robert MORETTI
  • Patent number: 8828902
    Abstract: A microencapsulated catalyst is prepared by dissolving or dispersing a catalyst in a first phase (for example an organic phase), dispersing the first phase in a second, continuous phase (for example an aqueous phase) to form an emulsion, reacting one or more microcapsule wall-forming materials at the interface between the dispersed first phase and the continuous second phase to form a microcapsule polymer shell encapsulating the dispersed first phase core and optionally recovering the microcapsules from the continuous phase. The catalyst is preferably a transition metal catalyst and the encapsulated catalyst may be used for conventional catalysed reactions. The encapsulated catalyst may recovered from the reaction medium and re-cycled.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: September 9, 2014
    Assignee: Reaxa Limited
    Inventors: Chandrashekar Ramarao, David Joszef Tapolczay, Ian Malcolm Shirley, Stephen Christopher Smith, Steven Victor Ley
  • Patent number: 8268751
    Abstract: The invention relates to novel insecticidal active compound combinations consisting, firstly, of anthranilamides and, secondly, of further insecticidally active compounds from the group of the pyrethroids, which combinations are highly suitable for controlling animal pests, such as insects.
    Type: Grant
    Filed: October 30, 2004
    Date of Patent: September 18, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Christian Funke, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Anton Kraus
  • Patent number: 8153688
    Abstract: Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: April 10, 2012
    Assignee: MCS Laboratories, Inc.
    Inventor: Donald Wesley Stoutamire
  • Publication number: 20120013244
    Abstract: An organic luminescent medium including an anthracene derivative represented by the following formula (1) and a compound having at least one electron-attracting group in the molecular structure thereof.
    Type: Application
    Filed: December 15, 2010
    Publication date: January 19, 2012
    Inventors: Masahiro Kawamura, Yumiko Mizuki, Yuichiro Kawamura, Hiroyuki Saito
  • Publication number: 20110308555
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: June 22, 2011
    Publication date: December 22, 2011
    Inventors: Johan SMETS, Hugo Robert Germain Denutte, An Pintens, Koen Van Aken, Freek Annie Camiel Vrielynck
  • Patent number: 8003788
    Abstract: A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: August 23, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Charles Alois Dvorak, Keena Lynn Green, Gary R. Lee
  • Patent number: 7964635
    Abstract: The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: June 21, 2011
    Assignee: Novartis AG
    Inventors: Noëlle Gauvry, Thomas Goebel, Pierre Ducray, François Pautrat, Ronald Kaminsky, Martin Jung
  • Publication number: 20110024691
    Abstract: Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties are derived from the incorporation of electron active substituents in selective positions.
    Type: Application
    Filed: November 10, 2009
    Publication date: February 3, 2011
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Roger Harquail French, Ross Getty, Simona Percec
  • Patent number: 7863475
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: January 4, 2011
    Assignee: Wellstat Therapeutics Corporation
    Inventor: Shalini Sharma
  • Patent number: 7807616
    Abstract: A fragrance preparation containing 3,7-dimethyloct-6-enenitrile and other compounds described herein is a geranonitrile substitute which has the advantages inherent to geranonitrile, such as fragrance freshness and composition stability but is less objectionable from a toxicological standpoint.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: October 5, 2010
    Assignee: Henkel AG & Co. KGaA
    Inventors: Georg Meine, Theo ten Pierik
  • Publication number: 20100249446
    Abstract: A method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline, wherein 4-cyano-3-trifluoromethylaniline is crystallized from a mixed solvent of methanol and water, and the obtained 4-cyano-3-trifluoromethylaniline is reacted with methacryloyl chloride improved separation property even in industrial production in a large scale.
    Type: Application
    Filed: September 2, 2008
    Publication date: September 30, 2010
    Inventors: Tadashi Katsura, Tadashi Mizuno
  • Publication number: 20100130757
    Abstract: The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (?) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis.
    Type: Application
    Filed: January 21, 2010
    Publication date: May 27, 2010
    Applicant: UNIVERSITY OF WYOMING
    Inventors: Robert C. Corcoran, Aaron D. Strickland
  • Patent number: 7705047
    Abstract: The invention relates to compounds of the general formula wherein either R signifies C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C2-C6-alkyl or halo-C1-C6-alkoxy-halo-C2-C6-alkyl; and X1 signifies a single bond, O, S, S(O) or S(O)2; or R signifies halogen and X1 signifies a single bond; X2 signifies CN, halogen, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-alkylsulfonylamino, halo-C1-C6-alkylsulfonylamino, OH, NH2, COOH, CONH2, C1-C6-alkylaminocarbonyl or C1-C6-alkylcarboxamido, whereby if n is greater than 1, X2 may differ from each other; m signifies 1, 2, 3 or 4; and n is 1, 2, 3, 4 or 5, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: April 27, 2010
    Assignee: Novartis AG
    Inventors: Thomas Goebel, Noëlle Gauvry, Pierre Ducray
  • Patent number: 7696382
    Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR1 or NR1R2 wherein each of R1 and R2 is independently H, or a hydrocarbyl group; X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO2-alkyl, alkenyl, CN, NH2, hydroxy, halo, alkoxy, CF3 and nitro; Y is a polar functional group selected from OH, NO2, CN, COR3, COOR3, NR3R4, CONR3R4, SO3H, SO2—R3, SO2NR3R4 and CF3, where each of R3 and R4 is independently H or a hydrocarbyl group; A is an aryl or heteroaryl group, each of which may be optionally substituted; and B is (CH2)n where n is 0, 1, 2, 3, 4 or 5; with the proviso that: (i) when A is phenyl, n is 0, and Z is OH, X—Y is other than meta-C?—C—(CH2)2CO2H, meta-C?—C—(CH2)2OH, meta-C?C—(CH2)2CO2Me, meta-(CH2)4CO2H, ortho-CH2CO2H, ortho-(CH2)2CO2H and ortho-(CH2)4CO2H; and (ii) when A is phenyl, n is 0, and Z is OMe, X—Y is other than meta-C?
    Type: Grant
    Filed: February 21, 2005
    Date of Patent: April 13, 2010
    Assignee: University College London
    Inventors: Masahiro Okuyama, David Selwood, Cristina Visintin, David Baker, Gareth Pryce
  • Publication number: 20100081208
    Abstract: A multirange indicator is proposed which permits quantitative dose determination of high-energy actinic radiation, where the dose for different wavelength ranges can be respectively determined in parallel. To this end, the multirange indicator has two indicator systems designed with mutually corresponding properties, thus eliminating any mutual distortion of the results of the dose measurements. The first indicator system is based on a photolatent Lewis acid or photolatent Lewis base, and the second indicator system is based on a polysubstituted triphenylmethane dye. Both the multirange indicator and its use for the production of various dose-measurement devices are described.
    Type: Application
    Filed: September 24, 2009
    Publication date: April 1, 2010
    Applicant: Tesa SE
    Inventors: Klaus KEITE-TELGENBÜSCHER, Hermann NEUHAUS-STEINMETZ
  • Publication number: 20100039027
    Abstract: An organic electroluminescent device including, a cathode, an anode, and at least an emitting layer and an electron transporting layer between the cathode and the anode, the emitting layer including a host compound and a fluoranthene compound, the electron transporting layer including a compound represented by (A)u-(B)v wherein A is a group containing an aromatic hydrocarbon group having 3 or more carbon rings, B is a heterocyclic group which may be substituted, and u and v are each an integer of 1 to 6.
    Type: Application
    Filed: February 19, 2008
    Publication date: February 18, 2010
    Applicant: IDEMITSU KOSAN CO., LTD
    Inventors: Yoriyuki Takashima, Masakazu Funahashi, Takashi Arakane, Yumiko Mizuki, Hiroshi Yamamoto, Chishio Hosokawa, Kiyoshi Ikeda
  • Patent number: 7655701
    Abstract: Compounds of formula (I) and their use as fragrance ingredients wherein R is selected from methyl, ethyl, propyl, isopropyl, methoxy and ethoxy; R is hydrogen or methyl; and n is 0 or 1.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: February 2, 2010
    Assignee: Givaudan SA
    Inventors: Felix Flachsmann, Jean-Pierre Bachmann
  • Publication number: 20100022640
    Abstract: Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations.
    Type: Application
    Filed: December 10, 2007
    Publication date: January 28, 2010
    Inventor: Donald Wesley Stoutamire
  • Publication number: 20090312558
    Abstract: The present invention relates to an efficient process for preparing an arylcyclopropanecarbonitrile, which involves the use of sulfolane as a solvent.
    Type: Application
    Filed: June 26, 2008
    Publication date: December 17, 2009
    Applicant: Reliance Life Sciences Pvt. Ltd.
    Inventors: Sandeep Pandurang Bhujbal, Venkata Ramana Kondepati, Rajesh Rao, Jayaraman Venkat Raman
  • Publication number: 20090253656
    Abstract: The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 represents a cyano group and the other represents a hydrogen atom; Ar1 represents a group selected from among the groups represented by formulas (2) to (4): and Ar2 represents an aromatic hydrocarbon group having a condensed ring which may be substituted by a halogen atom, or a group selected from among the groups represented by the following formulas (5) to (15): or a salt thereof.
    Type: Application
    Filed: March 29, 2006
    Publication date: October 8, 2009
    Applicant: Kabushiki Kaisha Yakult Honsha
    Inventors: Ryuta Yamazaki, Yukiko Nishiyama, Tomio Furuta, Takeshi Matsuzaki, Hiroshi Hatano, Oh Yoshida, Masato Nagaoka, Ritsuo Aiyama, Shusuke Hashimoto, Yoshikazu Sugimoto
  • Patent number: 7521006
    Abstract: Disclosed is a near-infrared absorbing compound which does not contain antimony or arsenic, and has excellent stability, especially excellent heat resistance, light resistance and moist heat resistance. Also disclosed are a near-infrared absorbing filter, which is produced by using the near-infrared absorbing compound, and has excellent resistance such as light resistance and heat resistance, an optical filter and an optical recording medium. Specifically disclosed are a diimmonium compound represented by the formula (1) below and a near-infrared absorbing filter obtained by using such a diimmonium compound. Further specifically disclosed are a near-infrared absorbing filter wherein an adhesive layer containing the diimmonium compound is arranged on a transparent supporting body, and an optical filter using such a near-infrared absorbing filter.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: April 21, 2009
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Masaaki Ikeda, Takaaki Kurata, Syouichi Kaneko, Junichi Segawa
  • Publication number: 20090088584
    Abstract: A process for preparing 3,4-disubstituted phenylacetic acids of the formula (I) in which X is fluorine, chlorine, bromine or iodine and R is C1-C4-alkylthio, C1-C4-alkylsulfonyl or C1-C4-alkylsulfoxide, starting from a 2-halo-C1-C4-alkylthiobenzene of the formula (II) in which X is as defined above and R1 is C1-C4-alkylthio.
    Type: Application
    Filed: January 22, 2007
    Publication date: April 2, 2009
    Inventors: John-Matthias Wiegand, Carsten Schafer, Melanie Palaoro, Wolfgang Skranc, Oliver Maurer
  • Publication number: 20090064426
    Abstract: The present invention relates to a dyestuff of the formula (I) wherein each of G1 and G2, independently is hydrogen, (C1-C4)-alkyl, trifluoromethyl, halogen, nitro, cyano or —SO2-T, wherein T is halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, aryl or aryloxy; K is a coupling component; and n is 1 or 2. The invention also relates to a process for its preparation and their use and for ink jet printing containing the ink.
    Type: Application
    Filed: March 2, 2007
    Publication date: March 12, 2009
    Applicant: DyStar Textilfarben GmbH & Co. Deutschland KG
    Inventors: Andreas Endres, Rainer Hamprecht, Hartwig Jordan, Anthony Lawrence, Nigel Hall
  • Patent number: 7494956
    Abstract: The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: February 24, 2009
    Assignee: Novartis AG
    Inventors: Noëlle Gauvry, Thomas Goebel, Pierre Ducray, François Pautrat, Ronald Kaminsky, Martin Jung
  • Publication number: 20090018340
    Abstract: The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).
    Type: Application
    Filed: July 1, 2005
    Publication date: January 15, 2009
    Inventors: Kevin R. Campos, Artis Klapars, J. Christopher McWilliams, C. Scott Shultz, Debra J. Wallace, Alex M. Chen, Lisa F. Frey, Andrey V. Peresypkin, Yaling Wang, Robert M. Wenslow, Cheng-Yi Chen
  • Patent number: 7468453
    Abstract: A process for the preparation of gamma-cyahlothrin comprising a) chlorinating 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid to give 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride; b) esterifying 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride with 3-phenoxy benzaldehyde in the presence of a source of cyanide to form a diastereoisomeric mixture of cyhalothrin isomers and c) epimerising the diastereoisomeric mixture under conditions in which the least soluble diastereoisomer crystallises from solution.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: December 23, 2008
    Assignee: Syngenta Limited
    Inventors: Stephen Martin Brown, Brian David Gott
  • Publication number: 20080265216
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: April 29, 2008
    Publication date: October 30, 2008
    Applicant: NOVALED AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Patent number: 7425580
    Abstract: The present invention concerns compounds of formula: where R1, R2, R3 and R4 are defined in the specification.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: September 16, 2008
    Assignee: Wyeth
    Inventors: Thomas Joseph Caggiano, Antony Aldo Brazzale
  • Publication number: 20080200554
    Abstract: Compounds of formula (I) and their use as fragrance ingredients wherein R is selected from methyl, ethyl, propyl, isopropyl, methoxy and ethoxy; R is hydrogen or methyl; and n is 0 or 1.
    Type: Application
    Filed: June 15, 2006
    Publication date: August 21, 2008
    Applicant: Givaudan SA
    Inventors: Felix Flachsmann, Jean-Pierre Bachmann
  • Patent number: 7390899
    Abstract: The present invention relates to a new process for the synthesis of high purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine of formula (I) using 2,3-dichlorobenzoyl cyanide and an aminoguanidine salt as starting materials. 2,3-dichlorobenzoyl cyanide is reacted with 1-2 mol equivalent of aminoguanidine salt in 3-6 mol equivalent of methanesulfonic acid, then the obtained adduct of formula (IV) is transformed without isolation into the product with magnesium oxide.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: June 24, 2008
    Assignee: Richter Gedeon Vegyeszeti Gyar. RT.
    Inventors: Jozsef Neu, Tibor Gizur, Jozsef Törley, Janos Csabai, Ferenc Vegh, Peter Kalvin, Gabor Tarkanyi
  • Patent number: 7390772
    Abstract: The present invention is directed to novel compounds of the general formula wherein R and R1 independently represent a hydrogen or a straight, branched or cyclic hydrocarbon moiety consisting of less than 15, preferably less than 10, most preferably less than 4 carbon atoms and containing single and/or double bonds. Another embodiment of the invention is a method for enhancing a perfume composition by incorporating an olfactory acceptable amount of the compound provided above.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: June 24, 2008
    Assignee: International Flavor & Fragrances Inc.
    Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Patrick M. Merritt, Franc T. Schiet
  • Publication number: 20080145946
    Abstract: Reference markers and reference standards for the determination of impurities in Anastrozole are provided.
    Type: Application
    Filed: January 31, 2008
    Publication date: June 19, 2008
    Inventors: Alessandro Pontiroli, Roberto Casalone
  • Patent number: 7323574
    Abstract: A process for the preparation of compound (III) which comprises the reaction between a compound of general formula (V) and dicyano acetylene (IV), said reaction carried out in the presence of water wherein R is selected from CF3, or C1 to C6 alkyl M is an alkaline or alkaline-earth metal or silver.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: January 29, 2008
    Assignee: BASF Agro B.V. Arnhem
    Inventors: Jean-Erick Ancel, Joelle Vidal
  • Patent number: 7304018
    Abstract: The invention relates to compounds of the general formula: (I) and optionally the enantiomers thereof. The active ingredients have advantages pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
    Type: Grant
    Filed: June 15, 2003
    Date of Patent: December 4, 2007
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Pierre Ducray, Thomas Goebel, Jacques Bouvier
  • Patent number: 7255853
    Abstract: Cosmetic compositions for topical use for protecting the skin and the hair, containing, in a cosmetically acceptable support, at least one compound of formula (1) or (2) in which X1 represents R3—(C?O)—, R3—SO2— or R3—O—(C?O)—, X2 represents —(C?O)—R?3—(C?O), —SO2—R?3—SO2— or —(C?O)—O—R?3—O—(C?O)—, Y represents —(C?O)—R4 or —SO2R5, R2 represents a C1-8 alkyl group, n is 0, 1 or 2, R3 represents C1-30 alkyl or C3-30 alkenyl, R?3 represents a single bond or a divalent C1-30 alkylene or C3-30 alkenylene radical, R4 represents —OR6 or —NHR6, R5 represents C1-30 alkyl or a phenyl nucleus, R6 represents C1-30 alkyl or C3-30 alkenyl, and novel compounds of formula (2).
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: August 14, 2007
    Assignee: L'Oreal
    Inventors: Hervé Richard, Bernadette Luppi
  • Patent number: 7241776
    Abstract: Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: July 10, 2007
    Assignee: Abbott Laboratories
    Inventors: William A. Carroll, Arturo Perez-Medrano, Sridhar Peddi, Alan S. Florjancic
  • Patent number: 7217682
    Abstract: A 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 2,2-dimethyl-3-(2-cyano-3-hydrocarbyloxy-3-oxo-1-propenyl) cyclopropanecarboxylate given by the formula (1): wherein G represents C1–C4 alkyl or C3–C4 alkenyl, has excellent pests controlling effect.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: May 15, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Tatsuya Mori
  • Patent number: 7012075
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 14, 2006
    Assignees: Merck & Co., Inc., Axys Pharmaceuticals, Inc.
    Inventors: Petpihoon Prasit, Christopher Ian Bayly, Joel Stephane Robichaud, W. Cameron Black, Eduardo L. Setti, Robert M. Rydzewski, James T. Palmer
  • Patent number: 7011838
    Abstract: The present invention relates to malononitrile compounds of formula wherein R1 and R2 are the same or different and independently C1–C5 (halo)alkyl, C1–C5 (halo)alkyloxy, C2–C5 (halo)alkenyl, C2–C5 (halo)alkynyl, hydrogen, or cyano; R3 is C1–C3 haloalkyl, C2–C4 haloalkenyl, or C2–C4 haloalkynyl; m is an integer of 1 to 3; R5 is halogen, cyano, nitro, C1–C4 (halo)alkyl, or the like; n is an integer of 0 to 4, with the proviso that when n is 2 or more, then R5's are the same or different from each other; R6 is hydrogen, halogen, cyano, nitro, C1–C4 (halo)alkyl, or the like; as well as pesticide compositions containing these compounds as active ingredients. The present invention makes it possible to effectively control pests such as insect pests, acarine pests, and nematode pests.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: March 14, 2006
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Ken Otaka, Daisuke Oohira, Satoshi Okada
  • Patent number: 7012095
    Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (I).
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: March 14, 2006
    Assignee: HSC Research and Development Limited
    Inventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe
  • Patent number: 6911554
    Abstract: This invention relates to compounds comprising isocyano derivatives tethered to solid supports for use in 3 and 4 component condensation reactions. The invention also relates to methods for synthesizing cyclic derivatives by a 3 and 4 component condensation reaction using the compounds of the invention.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: June 28, 2005
    Assignee: Array Biopharma Inc.
    Inventors: April Kennedy, John A. Josey
  • Patent number: 6846946
    Abstract: A method for preparing organic products from aqueous solutions, such as waste or byproduct liquid streams and waste or byproduct gas or vapor streams, uses phase transfer catalysis to transfer a chemical species in low concentration from the aqueous solution to the organic phase or the aqueous-organic interface. The system has little or no organic solvent, and the organic phase contains an electrophile which participates in the reaction. In one embodiment, the aqueous solution is contacted with the electrophile and a phase transfer catalyst and, optionally, a pH adjusting agent in the event that the chemical species in the aqueous solution is not sufficiently ionized to react with the electrophile, and optionally an organic solvent. A method for continuously converting a chemical species involves this contacting step, separating the phases, then dividing the organic phase into the product, the phase transfer catalyst, and the optional organic solvent.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: January 25, 2005
    Assignee: Value Recovery, Inc.
    Inventors: Peter J. Joyce, Roman Bielski, Marc Halpern
  • Patent number: 6812229
    Abstract: It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate derivative represented by the general formula [I] {wherein X is a halogen atom, a C1-C6 alkyl group or the like, n is 0 or an integer of from 1 to 4, R1 is a C1-C6 alkyl group, R2 is a hydrogen atom, a C1-C6 alkyl group or the like, R3 is a hydrogen atom or a C1-C6 alkyl group, G is an oxygen atom, a sulfur atom or the like, Y is a hydrogen atom, a C1-C10 alkyl group, C2-C10 alkenyl group or the like, and Q is a hydrogen atom, a C1-C6 haloalkyl group, a phenyl group or the like} and an agricultural/horticultural fungicide containing the same as the active ingredient.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: November 2, 2004
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Masami Ozaki, Shunichiro Fukumoto, Ryuji Tamai, Kazuhiro Ikegaya, Norihisa Yonekura, Takahiro Kawashima, Junetsu Sakai, Norimichi Muramatsu, Makikazu Takagaki, Kouzou Nagayama
  • Publication number: 20040214934
    Abstract: Novel ultraviolet absorbing compounds that are liquid in nature, are low in color (and thus permit use without the concomitant necessity of adding large amounts of other coloring agents to combat such discoloring), and are highly effective in providing protection in wavelength ranges for which previous attempts at low-color ultraviolet absorbers have failed are provided herein. Such compounds provide such excellent, inexpensive, and beneficial protection from ultraviolet exposure within various media, including, but not limited to, clear thermoplastics. The particular compounds are generally polymeric in nature including various chain lengths of polyoxyalkylenes thereon and are liquid in nature to facilitate handling and introduction within the target media. In addition, such ultraviolet absorbers also exhibit extremely low migratory properties thereby providing long-term protective benefits to the target media as well.
    Type: Application
    Filed: April 28, 2003
    Publication date: October 28, 2004
    Inventors: Jusong Xia, Mary E. Mason, Eric B. Stephens
  • Patent number: 6806281
    Abstract: The invention provides a compound of formula (I): wherein R1, R2, R3, and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermediates and methods useful for preparing a compound of formula I; and therapeutic methods for treating drug addiction, Parkinson's disease or depression comprising administering a compound of formula I, to a mammal in need of such treatment.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: October 19, 2004
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Gian Luca Araldi