Benzene Ring And Cyano Connected By A Chain Consisting Of Two Carbons Multiple Bonded To Each Other Patents (Class 558/401)
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Patent number: 6680390Abstract: The invention relates to the use of compounds of the formula I in which X is the divalent radical of oxygen, a carbonyl radical, optionally aliphatically substituted imino or the radical ═CR9R10, Y is a carbonyl group or the radical ═CR9R10, R1 and R2 are identical or different electron-withdrawing radicals, chosen from the group consisting of cyano, alkyl- or arylcarbonyl, alkyloxy- or aryloxycarbonyl, optionally substituted aminocarbonyl, alkyl- or arylsulfinyl, alkyl- or arylsulfonyl and optionally substituted aminosulfonyl, R3 is a hydrogen atom, a cyano, hydroxyl, carboxyl or aminocarbonyl group or a C5-C20-aryl radical or C1-C20-alkylradical optionally bonded via an oxygen bridge, an aminocarbonyl bridge or oxycarbonyl bridge, R4 is a hydrogen atom, a hydroxyl group, an amino group, or a C5-C20-aryl radical or C1-C20-alkyl radical optionally bonded via an oxygen bridge, and R5 to R10 independently of one another are hydrogen or C1-C20-alkyl radicals and where in additioType: GrantFiled: June 18, 2002Date of Patent: January 20, 2004Assignee: BASF AktiengesellschaftInventors: Frank Prechtl, Thorsten Habeck, Horst Westenfelder, Thomas Wilnsch
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Patent number: 6559216Abstract: Novel ultraviolet absorbing compounds that are liquid in nature, are extremely low in color (and thus permit use without the concomitant necessity of adding large amounts of other coloring agents to combat such discoloring), and are highly effective in providing protection in wavelength ranges for which previous attempts at low-color ultraviolet absorbers have failed are provided herein. Such compounds provide such excellent, inexpensive, and beneficial protection from ultraviolet exposure within various media, including, but not limited to, clear thermoplastics. The particular compounds are generally polymeric in nature including various chain lengths of polyoxyalkylenes thereon and are liquid in nature to facilitate handling and introduction within the target media. In addition, such ultraviolet absorbers also exhibit extremely low migratory properties thereby providing long-term protective benefits to the target media as well.Type: GrantFiled: August 21, 2001Date of Patent: May 6, 2003Assignee: Milliken & CompanyInventors: Xiaodong E. Zhao, Todd D. Danielson, Mary E. Mason, Daniel M. Connor, Eric B. Stephens, Jason D. Sprinkle, Jusong Xia
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Patent number: 6555702Abstract: A compound of the formula I: wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy, alkoxy of 1-6 carbon atoms —CO2Z, —O(CH2)mCO2Z, —SO3Z, —OPO3Z2; and Y is cyano, —C(NR1R2)═C(CN)2; wherein X═O or S, and R1 and R2 are independently H, benzyl, —CH(CH3)C6H6, —(CH2)n C6H6, phenyl; —CO2R; n=2-4; R is lower alkyl of 1-6 carbon atoms; m=1-4 and Z is H, a cation or lower alkyl of 1-6 cabon atoms; is used for treating inflammation, immunological diseases or diabetes.Type: GrantFiled: April 3, 1998Date of Patent: April 29, 2003Assignee: Calyx Therapeutics, Inc.Inventors: Subramaniam Sriram, John Bright, Bishwajit Nag, Somesh D. Sharma
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Patent number: 6555287Abstract: An improved light attenuating compound for use in the production of microdevices is provided. Broadly, the light attenuating compound is difunctional and can be directly incorporated (either physically or chemically) into photolithographic compositions such as anti-reflective coatings (ARC) and contact or via hole fill materials. The preferred light attenuating compound comprises functional groups electronically isolated from the light absorbing moieties of the compound. As a result, the spectral properties of the compound are not negatively affected when the functional groups form bonds with other compounds during polymerization or crosslinking.Type: GrantFiled: October 10, 2000Date of Patent: April 29, 2003Assignee: Brewer Science, Inc.Inventor: Shreeram V. Deshpande
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Publication number: 20020137961Abstract: The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.Type: ApplicationFiled: September 17, 2001Publication date: September 26, 2002Inventors: Stuart E. Bradley, Eric W. Collington, Matthew C. Fyfe, William T. Gattrell, Joanna V. Geden, Peter J. Murray, Martin J. Procter, Robert J. Rowley, Jonathan G. Williams
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Patent number: 6444279Abstract: Acetylene derivatives of the formula I in which R, A1, A2, Z1, Z2, Z3, L1, L2, L3, Y, m and n are as defined herein are suitable as components of liquid-crystalline media.Type: GrantFiled: January 24, 2000Date of Patent: September 3, 2002Assignee: Merck Patent GmbHInventors: Volker Reiffenrath, Harald Hirschmann
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Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications
Patent number: 6379590Abstract: A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D wherein A′ is selected from the group consisting of —Br, —Cl, —F, —NO2, and —CN; A is selected from the group consisting of —NO2, —CN, —CO2R, —C(O)R, —SO2R, —SO2RF, —C(CN)═C(CN)2 and —CH═C(CN)2; RF is —CpF2p+1, p=from about 0 to about 10; R is an straight, branched or cyclic aliphatic alkyl group having about 1 to 10 carbon atoms, or an aromatic group such as phenyl or naphthyl; and is a carbonyl or a protected carbonyl such as a ketal or thio-ketal such as wherein R′ is —CrH2r+1; R″ is —(CH2)r—; and r is independently 2 or 3, with a nucleophilic reagent in the presence of an aprotic solventType: GrantFiled: December 2, 1994Date of Patent: April 30, 2002Assignee: AlliedSignal Inc.Inventors: Chengjiu Wu, Jianhui Shan -
Patent number: 6369226Abstract: Nonpeptide benzamide-containing inhibitors of human rhinovirus (HRV) 3C protease are described.Type: GrantFiled: June 20, 2000Date of Patent: April 9, 2002Assignee: Agouron Pharmaceuticals, Inc.Inventors: Siegfried Heinz Reich, Susan Elizabeth Kephart, Michael Brennan Wallace, Theodore Otto Johnson, Jr.
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Publication number: 20020019556Abstract: The present invention provides a process for the preparation of pesticidal 1,4-diaryl-2-fluoro-4-cyano-2 -butene compounds having the structural formula I 1Type: ApplicationFiled: May 4, 2001Publication date: February 14, 2002Applicant: Intl Prop Dept, BASF AktiengesellschaftInventors: Yulin Hu, David Allen Hunt
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Publication number: 20010056107Abstract: Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor &agr;, nuclear factor &kgr;B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.Type: ApplicationFiled: July 16, 2001Publication date: December 27, 2001Inventors: George W. Muller, Mary Shire
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Patent number: 6331564Abstract: The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P, the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.Type: GrantFiled: September 23, 1998Date of Patent: December 18, 2001Assignee: Ion Pharmaceuticals, Inc.Inventors: Carlo Brugnara, Jose Halperin, Emile M. Bellot, Jr., Mark Froimowitz, Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Falguni M. Kher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft
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Patent number: 6248893Abstract: Infrared radiation-sensitive compounds have been found that are represented by Structure DYE as follows: wherein R is a secondary or tertiary amine that contains no heterocyclic group, R1 and R2 are independently carbocyclic aromatic groups, and M+ is a monovalent cation. These compounds have a &lgr;max above 700 nm and are can be used in a number of photosensitive or heat-sensitive imaging materials.Type: GrantFiled: June 8, 2000Date of Patent: June 19, 2001Assignee: Eastman Kodak CompanyInventors: Kevin W. Williams, Shiying Zheng, Thap DoMinh
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Patent number: 6207716Abstract: Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.Type: GrantFiled: October 30, 1998Date of Patent: March 27, 2001Assignee: Glaxo Wellcome Inc.Inventor: Timothy Mark Willson
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Patent number: 6153784Abstract: Halides are removed from halide-containing nitrile mixtures by(a) thermally treating the halide-containing nitrile mixture,(b) subsequently adding a base to the thermally treated nitrile mixture and(c) subsequently separating off the base from the nitrile mixture.Amines are prepared by(A) reacting alkyl halides with metal cyanides in an at least two-phase reaction medium in the presence of halide-containing phase-transfer catalysts to give alkanenitriles,(B) separating off the resulting halide-containing alkanenitrile mixture phase and(C) further treating the halide-containing alkanenitrile mixture phase, as described in the stages(a)-(c) removing halides from halide-containing nitrile mixtures and(d) hydrogenating nitrites obtained in stage (c) to give amines, in the presence of suspended or fixed-bed catalysts.Type: GrantFiled: February 17, 1998Date of Patent: November 28, 2000Assignee: BASF AktiengesellschaftInventors: Heinz-Josef Kneuper, Hans-Jurgen Weyer, Horst Neuhauser, Johann-Peter Melder, Andreas Henne, Karl-Heinz Ross, Rainer Becker
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Patent number: 6107508Abstract: The present invention relates to processes for the production of .alpha.-aryl-.beta.-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.Type: GrantFiled: March 31, 1999Date of Patent: August 22, 2000Assignee: Dupont Pharmaceuticals CompanyInventors: Jiacheng Zhou, Lynette May Oh, Philip Ma
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Patent number: 6096918Abstract: The acrylic acid esters of Formula I are useful for the delivery of organoleptic compounds, especially for flavors, fragrances, masking agents and antimicrobial compounds. They can also deliver fluorescent whitening agents.Type: GrantFiled: February 12, 1999Date of Patent: August 1, 2000Assignee: Givaudan Roure (International) SAInventors: Denise Anderson, Georg Frater
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Patent number: 6028103Abstract: The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. The compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.Type: GrantFiled: March 19, 1997Date of Patent: February 22, 2000Assignees: Children's Medical Center Corporation, Ion Pharmaceuticals, Inc.Inventors: Carlo Brugnara, Jose Halperin, Emile M. Bellot, Jr., Mark Froimowitz, Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Falguni M. Kher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft
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Patent number: 5981569Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction and particularly KDR/FLK-1 receptor signal transduction in order to regulate and/or modulate vasculogenesis and angiogenesis. The invention is based, in part, on the demonstration that KDR/FLK-1 tyrosine kinase receptor expression is associated with endothelial cells and the identification of vascular endothelial growth factor (VEGF) as the high affinity ligand of FLK-1. These results indicate a major role for KDR/FLK-1 in the signaling system during vasculogenesis and angiogenesis. Engineering of host cells that express FLK-1 and the uses of expressed FLK-1 to evaluate and screen for drugs and analogs of VEGF involved in FLK-1 modulation by either agonist or antagonist activities is also described.Type: GrantFiled: June 5, 1995Date of Patent: November 9, 1999Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Sugen, Inc.Inventors: Harald App, Gerald M. McMahon, Peng Cho Tang, Aviv Gazit, Alexander Levitzki
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Patent number: 5951841Abstract: Salts of aromatic hydroxy compounds are used as brighteners in acidic electroplating baths. Furthermore, acidic electroplating baths for the electrolytic deposition of metallic layers onto shaped articles comprise, as brighteners, at least one novel salt of an aromatic hydroxy compound. Finally, shaped articles are electroplated by a process using the novel acidic electroplating baths.Type: GrantFiled: October 6, 1997Date of Patent: September 14, 1999Assignee: BASF AktiengesellschaftInventors: Thomas Wehlage, Ulrich Schroder, Alfred Oftring
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Patent number: 5929117Abstract: Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor .alpha., nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.Type: GrantFiled: August 11, 1997Date of Patent: July 27, 1999Assignee: Celgene CorporationInventors: George W. Muller, Mary Shire
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Patent number: 5888481Abstract: The invention relates to novel cinnamamides, a process for their manufacture and their use as UV absorbers. The cinnamamides of the invention may be used as UV absorbers in a variety of engineered resins such as polyamides (especially nylon 6 and 6,6), polycarbonates, polyacetals, polysulfones, polyimides, polyaryletherketones, and polyesters, (especially PET and PBT), as well as, other polymers such as polyvinylchloride and polyolefins (polyethylenes and polypropylenes).Type: GrantFiled: September 29, 1995Date of Patent: March 30, 1999Assignee: AlliedSignal Inc.Inventors: Keith A. Horn, Richard B. Heath, David B. Schwind
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Patent number: 5877219Abstract: Described herein are non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.Type: GrantFiled: June 18, 1997Date of Patent: March 2, 1999Assignee: Glaxo WellcomeInc.Inventor: Timothy Mark Willson
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Patent number: 5830441Abstract: A photostable UV absorbent with maximum absorption above 340 nm having the formula: ##STR1## wherein R is --CO(R.sub.2) or phenyl optionally substituted with lower alkyl and/or lower alkoxy;R.sub.2 is --alkyl, --O(C.sub.2+ alkyl), ##STR2## n has a value of from 2 to 8; S and T each independently are hydroxy, lower alkyl, lower alkoxy or, when R.sub.2 is alkyl or alkoxy, S can also be phenyl and when R.sub.2 is alkoxy, T is alkoxy, or S+T taken with the phenyl ring form a naphthyl radical or a fused benzodioxol-5-yl heterocyclic radical;k+l has a value of from 0 to 3 with the proviso that, when R.sub.2 is--O(alkyl), T is --O(lower alkyl) and the value of l is 2 or 3;R.sub.3 is hydrogen or lower alkylene;R.sub.4, R.sub.5, and R.sub.6 are each independently C.sub.1 to C.sub.18 alkyl or one of R.sub.4, R.sub.5 and R.sub.6 can be phenyl andA is an anion.Type: GrantFiled: January 20, 1998Date of Patent: November 3, 1998Assignee: ISP Investments Inc.Inventors: Chenjie Wang, Ratan K. Chaudhuri, Janusz Jachowicz, Bruce C. Locke, Frank M. Miksza
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Patent number: 5789448Abstract: Disclosed is a benzoylethylene derivative represented by the following formula (I) or a salt thereof. ##STR1## R.sup.1 to R.sup.5 : a hydrogen atom, --OR.sup.9 (R.sup.9 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc.), etc.,R.sup.6 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc.,R.sup.7 : a hydrogen atom, a cyano group, a C.sub.1 -C.sub.5 alkyl group, --SO.sub.q R.sup.15 (q: 0, 1, 2, R.sup.15 : a thienyl group, a phenyl group, etc.) etc.,R.sup.8 : a cyano group, --CR.sup.22 R.sup.23 X (R.sup.22, R.sup.23 : a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, etc., X: --NR.sup.24 R.sup.25 (R.sup.24, R.sup.25 : a C.sub.1 -C.sub.5 alkyl group, etc., an alkylene group by combining, etc.)), etc.The benzoylethylene derivative of the present invention has potent tyrosine kinase inhibiting activity and cancer cell growth inhibiting activity. The tyrosine kinase inhibitor of the present invention is useful as a carcinostatic agent.Type: GrantFiled: June 25, 1996Date of Patent: August 4, 1998Assignee: Mitsubishi Chemical CorporationInventors: Yasunori Kitano, Haruki Inokawa, Hisao Takayanagi, Tamaki Yano, Hiroe Umeki, Hiroto Hara
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Patent number: 5703265Abstract: A compound having the structure: ##STR1## is disclosed. R.sup.1 is defined in the specification. The compounds are charged control agents for use in electrostatographic toners and developers.Type: GrantFiled: May 10, 1996Date of Patent: December 30, 1997Assignee: Eastman Kodak CompanyInventors: John C. Wilson, Peter S. Alexandrovich
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Patent number: 5696243Abstract: Diphenylamines of the formula ##STR1## where the ring A can be benzo-fused, andD is aryl or a five-membered aromatic heterocyclyl which contains one to three hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur, in the heterocyclic ring and can be fused to a benzene, thiophene, pyridine or pyrimidine ring,X is N.dbd.N or, if D is aryl, is alternatively CH.dbd.CH, or D--X together is 1,2,2-tricyanovinyl,R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or halogen,R.sup.5 is prop-1-en-3-yl, acryloyl or methacryloyl,R.sup.6 and R.sup.7 are each hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, prop-1-en-3-yl, acryloyl, methacryloyl or oxiranylmethoxy, andY is C.sub.1 -C.sub.20 -alkylene,polymers derived from the compounds, and their use in non-linear optics.Type: GrantFiled: April 19, 1996Date of Patent: December 9, 1997Assignee: GASF AktiengesellschaftInventors: Stefan Beckmann, Karl-Heinz Etzbach, Ruediger Sens
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Patent number: 5681835Abstract: Prescribed herein are novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.Type: GrantFiled: April 25, 1994Date of Patent: October 28, 1997Assignee: Glaxo Wellcome Inc.Inventor: Timothy Mark Willson
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Patent number: 5663410Abstract: The present invention relates to the compounds cis-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and trans-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and to a process for their preparation.Type: GrantFiled: November 6, 1995Date of Patent: September 2, 1997Assignee: Hoechst AktiengesellschaftInventors: Matthias Beller, Ralf Pfirmann
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Patent number: 5650511Abstract: Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.Type: GrantFiled: December 12, 1995Date of Patent: July 22, 1997Assignee: BioCryst Pharmaceuticals, Inc.Inventors: Arthur J. Elliott, David A. Walsh
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Patent number: 5627207Abstract: The present invention provides compounds of the formula ##STR1## wherein Y is a naphthyl, tetrahydronaphthyl, pyridyl, quinolyl, isoquinolyl or indolyl ring system, R is a moiety which is an acrylic acid, a CN-substituted acrylic acid, acrylamide, acrylonitrile or thioacrylamide, or a group of formulae (e) to (j): ##STR2## wherein R.sub.3 is OH or NH.sub.2, R.sub.1 is H, alkyl or alkanoyl, R.sub.2 is H, halogen, CN or alkyl; and n is 0, 1, 2 or 3; and the pharmaceutically acceptable salts thereof are useful as tyrosine kinase inhibitors.Type: GrantFiled: May 31, 1995Date of Patent: May 6, 1997Assignee: Farmitalia Carlo Erba S r lInventors: Franco Buzzetti, Antonio Longo, Maristella Colombo
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Patent number: 5567418Type: GrantFiled: June 5, 1995Date of Patent: October 22, 1996Assignee: L'OrealInventors: Serge Forestier, Andre Deflandre
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Patent number: 5538716Abstract: A photostable cosmetic composition for protecting the human epidermis against UV radiation comprises, in a cosmetically acceptable carrier, from 0.5 to 5% by weight of 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane and at least 0.5% by weight of a compound of formula (I): ##STR1## where R stands for an alkyl radical, the molar ratio of the compound of formula (I) to 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane being 0.8 or over.Type: GrantFiled: April 7, 1993Date of Patent: July 23, 1996Assignee: L'OrealInventors: Serge Forestier, Andre Deflandre
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Patent number: 5514711Abstract: Styrene derivatives of the following general formula (I): ##STR1## or pharmaceutically acceptable salts thereof. A pharmaceutical composition useful as anticancer agent, which comprises the above compound as an essential component, is also provided.Type: GrantFiled: January 5, 1995Date of Patent: May 7, 1996Assignee: Mitsubishi Chemical CorporationInventors: Yasunori Kitano, Hisao Takayanagi, Koichi Sugawara, Hiroto Hara, Hideo Nakamura, Toshiko Oshino
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Patent number: 5468870Abstract: Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR.sup.1 or CONR.sup.2 R.sup.3 ;R.sup.1, R.sup.2 and R.sup.3 each independently represent hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or R.sup.2 and R.sup.3 together represent the necessary atoms to close a heterocyclic nucleus or substituted heterocyclic nucleus;Y represents OR.sup.4 or NR.sup.5 R.sup.6 or CN;R.sup.4 represents hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, SO.sub.2 R.sup.7, COR.sup.7, CSR.sup.7, POR.sup.7 R.sup.8 ;R.sup.5 and R.sup.6 each independently has one of the significances given to R.sup.4 or represent substituted or unsubstituted amino, or R.sup.5 and R.sup.Type: GrantFiled: October 20, 1994Date of Patent: November 21, 1995Assignee: AGFA-GAVAERT, N.V.Inventor: Luc J. Vanmaele
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Patent number: 5446194Abstract: A compound according to formula 1 ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms or which is substituted with hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable esters and salts thereof, and a pharmaceutically acceptable carrier therefor, as well as pharmaceutical compositions containing said compounds as COMT inhibitors.Type: GrantFiled: September 16, 1993Date of Patent: August 29, 1995Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 5442086Abstract: Disclosed are certain poly-methine compounds having the formula ##STR1## wherein each R.sup.1 is independently selected from cyano; carboxy; alkenyloxycarbonyl; an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; an unsubstituted or substituted, carbocyclic or heterocyclic aryl radical; an unsubstituted or substituted alkanoyl, cycloalkanoyl or aroyl radical; an unsubstituted or substituted carbamoyl radical; or an unsubstituted or substituted alkylsulfonyl, cycloalkylsulfonyl or arylsulfonyl radical; each R.sup.2 is independently selected from cyano or an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; each A is independently selected from an unsubstituted or substituted 1,2-phenylene or 1,2-naphthylene radical; each Z is independently selected from --0-- or --S--; and L is an organic linking group bonded by non-oxo carbon atoms to each Z atom.Type: GrantFiled: September 19, 1994Date of Patent: August 15, 1995Assignee: Eastman Chemical CompanyInventors: James J. Krutak, Max A. Weaver, Clarence A. Coates, Jr., Samuel D. Hilbert, Terry A. Oldfield, William W. Parham, Wayne P. Pruett
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Patent number: 5399690Abstract: Solid particle dispersions of dyes according to the formula: ##STR1## wherein D is selected from the group consisting of ##STR2## and ketomethylene nuclei are disclosed as filter dyes for photographic elements.In this formula, E.sup.1 and E.sup.2 are each independently electron withdrawing groups. R.sup.1 and R.sup.6 are each independently R or NHR, where R is aryl. R.sup.2 and R.sup.3 are each independently alkyl or aryl, or represent the carbon atoms necessary to form a fused ring with the phenyl ring to which the N atom is attached. R.sup.4 and R.sup.7 are each independently hydrogen, alkyl or aryl. R.sup.5 is alkyl. Z represents the atoms necessary to complete a 5 or 6 memebered heterocyclic nucleus. M.sup.+ is a cation. L.sup.1 through L.sup.7 are each independently methine groups. m is 0, 1, 2, or 3. n is 0 or 1. p is 0, 1, 2, 3, or 4. q is 0, 1, 2, or 3. At least one of R.sup.1 or D includes an aryl ring substituted with a carboxy or sulfonamido substituent.Type: GrantFiled: February 10, 1993Date of Patent: March 21, 1995Assignee: Eastman Kodak CompanyInventors: Donald R. Diehl, Glenn M. Brown, Margaret J. Helber
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Patent number: 5374419Abstract: Disclosed are sunscreen compositions containing certain poly-methine compounds having the formula ##STR1## wherein each R.sup.1 is independently selected from cyano; carboxy; alkenyloxycarbonyl; an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; an unsubstituted or substituted, carbocyclic or heterocyclic aryl radical; an unsubstituted or substituted alkanoyl, cycloalkanoyl or aroyl radical; an unsubstituted or substituted carbamoyl radical; or an unsubstituted or substituted alkylsulfonyl, cycloalkylsulfonyl or arylsulfonyl radical; each R.sup.2 is independently selected from cyano or an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; each A is independently selected from an unsubstituted or substituted 1,2-phenylene or 1,2-naphthylene radical; each Z is independently selected from --O-- or --S--; and L is an organic linking group bonded by non-oxo carbon atoms to each Z atom.Type: GrantFiled: December 18, 1992Date of Patent: December 20, 1994Assignee: Eastman Chemical CompanyInventors: James J. Krutak, Max A. Weaver, Clarence A. Coates, Jr., Samuel D. Hilbert, Terry A. Oldfield, William W. Parham, Wayne P. Pruett
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Patent number: 5354511Abstract: Compounds having non-linear optical activity of the general formula ##STR1## wherein D and A are electron donor and acceptor groups, respectively, R.sup.1 and R.sup.2 are aromatic bridging groups, X and Y are preferably groups capable of partaking in polymerization reactions are suitable for use in polymer-based light modulator devices.Type: GrantFiled: November 27, 1992Date of Patent: October 11, 1994Assignee: AlliedSignal Inc.Inventors: Chengjiu Wu, Jianhui Shan, Ajay Nahata
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Patent number: 5354777Abstract: New cyanoalkene derivatives of the formula (I) ##STR1## are described, in which R and R.sup.1 have the meaning given in the description, and a process for their preparation.The new cyanoalkene derivatives are used for combating microorganisms for the protection of industrial materials.Type: GrantFiled: February 23, 1993Date of Patent: October 11, 1994Assignee: Bayer AktiengesellschaftInventors: Peter Wachtler, Wilfried Paulus, Georg-Wilhelm Ludwig
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Patent number: 5334750Abstract: Cinnamic acid derivatives, in particular 2-ethylhexyl p-methoxycinnamate and 2-isoamyl p-methoxycinnamate, are prepared avoiding particular effort for workplace hygiene and ecology by using bromoaromatic and acrylic acid derivatives in the presence of palladium catalysts and a large excess of phosphane (based on the palladium), in the presence of an inorganic base and in the presence of alcohols and/or a phase transfer catalyst.Type: GrantFiled: March 31, 1993Date of Patent: August 2, 1994Assignee: Bayer AktiengesellschaftInventors: Dieter Kaufmann, Carsten Hesse, Thomas Himmler
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Patent number: 5302740Abstract: Disclosed are certain poly-methine compounds having the formula ##STR1## wherein each R.sup.1 is independently selected from cyano; carboxy; alkenyloxycarbonyl; an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; an unsubstituted or substituted, carbocyclic or heterocyclic aryl radical; an unsubstituted or substituted alkanoyl, cycloalkanoyl or aroyl radical; an unsubstituted or substituted carbamoyl radical; or an unsubstituted or substituted alkylsulfonyl, cycloalkylsulfonyl or arylsulfonyl radical; each R.sup.2 is independently selected from cyano or an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; each A is independently selected from an unsubstituted or substituted 1,2-phenylene or 1,2-naphthylene radical; each Z is independently selected from --O-- or --S--; and L is an organic linking group bonded by non-oxo carbon atoms to each Z atom.Type: GrantFiled: October 30, 1992Date of Patent: April 12, 1994Assignee: Eastman Kodak CompanyInventors: James J. Krutak, Max A. Weaver, Clarence A. Coates, Jr., Samuel D. Hilbert, Terry A. Oldfield, William W. Parham, Wayne P. Pruett
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Patent number: 5283352Abstract: Catechol compounds of formula I ##STR1## where R.sub.1, R.sub.2, R.sub.3 and X are as described herein are effective Catechol-O-methyltransferase inhibitors.Type: GrantFiled: December 7, 1992Date of Patent: February 1, 1994Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 5279764Abstract: The invention relates to dihalogenobenzene derivatives of the formula IR.sup.1 --A.sup.1 --Z.sup.1 --A.sup.2 --(Z.sup.2 --A.sup.3).sub.n --R.sup.2wherein R.sup.1, R.sup.2, A.sup.1, A.sup.2, A.sup.3, Z.sup.1, Z.sup.2 and n are as defined in the specification.Type: GrantFiled: November 23, 1992Date of Patent: January 18, 1994Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Volker Reiffenrath, Joachim Krause, Georg Weber, Ulrich Finkenzeller, Andreas Wachtler, Thomas Geelhaar, David Coates, Ian C. Sage, Simon Greenfield
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Patent number: 5214186Abstract: A process for the preparation of arylidene dyes comprises the reaction of an aromatic amine with an enolate salt of a formylated active methylene compound in the presence of a sulfonyl halide compound. An enol sulfonate is postulated as a reactive intermediate in the reaction. The process gives high yields of products under mild reaction conditions and allows the use of aromatic groups containing substituents such as hydroxy that lead to side reactions and low product yields with previously known methods for making arylidene dyes.Type: GrantFiled: December 3, 1991Date of Patent: May 25, 1993Assignee: Eastman Kodak CompanyInventor: Leslie Shuttleworth
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Patent number: 5196147Abstract: An organic nonlinear optical substance having the formula (I): ##STR1## wherein R.sup.1 represents --H or --CH.sub.3 ;n is 0, 1, or 2;A represents Z.sup.1 --Ar, ##STR2## wherein Ar represents a 6-14 membered aromatic group including a heterocyclic ring or bisphenylene type ring; Z.sup.1 represents H--, R.sup.5 R.sup.6 N--, R.sup.7 O--, R.sup.8 S--, NC--, R.sup.9 OCO--, R.sup.10 COO--, O.sub.2 N--, R.sup.11 R.sup.12 NOC, R.sup.13 CO(R.sup.14)N--, or R.sup.15 --; Z.sup.2, Z.sup.3, and Z.sup.4 independently represent H--, a C.sub.1 -C.sub.8 alkyl--, R.sup.16 O--, R.sup.17 R.sup.18 N, R.sup.19 S--, O.sub.2 N--, or two R.sup.16 being, in combination, R.sup.20 CH<; R.sup.2 represents H-- or a C.sub.1 -C.sub.12 alkyl; R.sup.5 to R.sup.20 independently represent H--, or a C.sub.1 -C.sub.10 hydrocarbon residue; Z.sup.5 independently represents H--, a C.sub.1 -C.sub.8 saturated hydrocarbon residue, O.sub.2 N--, R.sup.21 O--, R.sup.22 S--, NC--, or R.sup.23 R.sup.24 N-- wherein R.sup.21 to R.sup.Type: GrantFiled: March 28, 1989Date of Patent: March 23, 1993Assignee: Teijin LimitedInventors: Yutaka Taketani, Hiroshi Matsuzawa, Kaoru Iwata
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Patent number: 5166395Abstract: Fungicidal 3-cyano-4-phenyl-pyrroles of the formula ##STR1## in which R.sup.1 represents chlorine, bromine, alkyl, halogenoalkyl or halogenoalkoxy,R.sup.2 represents chlorine, bromine, alkyl, halogenoalkyl or halogenoalkoxy andR.sup.3 represents hydrogen or fluorine,with the proviso that at least one of the radicals R.sup.1 or R.sup.2 represents halogenoalkyl.Type: GrantFiled: September 13, 1991Date of Patent: November 24, 1992Assignee: Bayer AktiengesellschaftInventors: Detlef Wollweber, Wilhelm Brandes, Stefan Dutzmann, Gerd Hanssler
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Patent number: 5135950Abstract: Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).Type: GrantFiled: October 31, 1990Date of Patent: August 4, 1992Assignee: Orion-yhtyma OyInventors: Aino K. Pippuri, Erkki J. Honkanen, Jorma V. Haarala
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Patent number: 5124326Abstract: A pharmaceutically efficacious pteridine compound of formula I: ##STR1## wherein A denote a bridging hydrocarbon group containing 1 to 8 carbon atoms and containing a ##STR2## group directly bonded to the phenyl group and one of the methylene radicals of the bridging A group is optionally replaced by --O--; R.sub.1 is hydrogen, a cycloalkyl group with up to 7 carbon ring atoms, or an alkyl group having 1 to 6 carbon atoms, benzyl, or aryl; R.sub.2 is hydrogen or an alkyl group having 1 to 6 carbon atoms, or wherein R.sub.1 and R.sub.2 together form a five- or six-membered heterocyclic group which optionally contains additional hetero atoms selected from the group consisting of nitrogen, oxygen, and sulfur; R.sub.3 is hydrogen or an alkyl group having 1 to 3 carbon atoms; R.sub.3 ' is hydrogen, an optionally substituted alkyl group having 1 to 3 carbon atoms, carboxyl, hydroxyl or R.sub.3 and R.sub.Type: GrantFiled: April 20, 1990Date of Patent: June 23, 1992Assignee: Roehm GmbH Chemische FabrikInventors: Ernst Mutschler, Angelika Christner, Ingrid Hofmann
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Patent number: 5063243Abstract: Novel derivatives of caffeic acid of the general formula (I): ##STR1## wherein X is hydrogen atom or hydroxy; R.sup.1 is hydrogen atom, a straight or branched alkyl or alkenyl having 1 to 20 carbon atoms or a group of the formula:--(CH.sub.2).sub.n --Z--R.sup.2wherein n is an integer of 1 to 10; Z is oxygen atom, vinylene residue or a single bond; and R.sup.2 is a substituted or unsubstituted phenyl or heterocyclic residue is provided. These derivatives possess 12-lipoxygenase inhibitory activity and are useful for curing and preventing circulatory diseases. A pharmaceutical composition containing said derivtive is also provided.Type: GrantFiled: April 28, 1989Date of Patent: November 5, 1991Assignee: Suntory, Ltd.Inventors: Hidetsura Cho, Masaru Ueda, Mie Tamaoka, Mikiko Hamaguchi, Seiitsu Murota, Ikuo Morita