Six-membered Alicyclic Ring Containing Patents (Class 558/430)
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Patent number: 9200237Abstract: It is intended to provide a compound and a fragrance composition containing the compound, wherein the compound is useful as a fragrance, has floral and green odors in addition to a strong muguet odor, is stable in an aqueous vehicle, and can be blended with another fragrance to have enhanced freshness and diffusibility. It also is intended to provide 4,8-dimethyl-4,9-decadienenitrile and a fragrance composition containing 4,8-dimethyl-4,9-decadienenitrile.Type: GrantFiled: February 19, 2014Date of Patent: December 1, 2015Assignee: Kao CorporationInventors: Takashi Aoki, Takahiro Hirose, Shoichi Tahara
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Publication number: 20150097146Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: ApplicationFiled: December 15, 2014Publication date: April 9, 2015Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
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Patent number: 8951443Abstract: Organic semiconducting material comprising at least one matrix material and at least one doping material, wherein the doping material is selected from a [3]radialene compound, and wherein the matrix material is selected from a terphenyldiamine compound, as well as an organic component and a mixture for producing a doped semiconductor layer.Type: GrantFiled: April 27, 2011Date of Patent: February 10, 2015Assignees: Novaled AG, Sensient Imaging Technologies GmbHInventors: Ansgar Werner, Sascha Dorok, Carsten Rothe, Michael Felicetti, Volker Lischewski, Mirko Tschunarjew
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Patent number: 8911645Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: GrantFiled: November 14, 2013Date of Patent: December 16, 2014Assignee: Novaled AGInventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
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Patent number: 8853449Abstract: Process for the industrial synthesis of the compound of formula (I)Type: GrantFiled: January 4, 2012Date of Patent: October 7, 2014Assignee: Les Laboratoires ServierInventors: Samir Zard, Béatrice Sire, Mehdi Boumediene
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Publication number: 20140150380Abstract: Disclosed are compounds of formula (1) and (2) and/or E/E-, E/Z- or Z/Z geometrical isomer forms thereof; wherein R1-R5, R1-R11 and A are defined as in description. The compounds are used as UV absorbers for protecting household products from photolytic and oxidative degradation, as plastic additives, preferably for food and pharmaceutical packaging applications, for preventing photo-degradation of food by incorporation of the compounds of formula (1?) and/or (2?) into transparent food containers, for protection of UV-A sensitive drugs from photo-degradation by incorporation of UV absorber in transparent blister foils or transparent pharmacy containers, as additives for photographic and printing applications, as additives for electronic applications and protecting the ingredients in agriculture applications.Type: ApplicationFiled: July 19, 2012Publication date: June 5, 2014Inventors: Barbara Winkler, Dietmar Hueglin, Kai Eichin, Larissa Ehrsam, Xavier Marat, Hervé Richard, ILona Marion Kienzle, Ute Schroeder
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Publication number: 20140070145Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: ApplicationFiled: November 14, 2013Publication date: March 13, 2014Applicant: NOVALED AGInventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
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Patent number: 8617426Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: GrantFiled: July 8, 2011Date of Patent: December 31, 2013Assignee: Novaled AGInventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
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Publication number: 20130330582Abstract: A secondary battery includes: a cathode; an anode; and an electrolytic solution including a cyano compound, the cyano compound including a compound represented by R1-O—C(?O)—O—R2 (R1, R2, or both include a cyano-group-containing group), a compound represented by R3-C(?O)—O—R4 (R4 includes the cyano-group-containing group), or both.Type: ApplicationFiled: June 3, 2013Publication date: December 12, 2013Inventors: Masayuki Ihara, Tadahiko Kubota
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Patent number: 8455544Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.Type: GrantFiled: January 26, 2012Date of Patent: June 4, 2013Assignees: Reata Pharmaecuticals, Inc., Trustees of Dartmouth CollegeInventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
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Publication number: 20130083284Abstract: The present invention relates to a switch element, which is thermo-responsive and which switches between a less transmissive state for radiant energy and a more transmissive state for radiant energy, and which comprises a liquid-crystalline medium. The invention furthermore relates to the use of the switch element for the regulation of radiant energy flow between interior spaces and the environment and for the regulation of the temperature of interior spaces. The invention furthermore relates to a liquid-crystalline medium, characterised in that it comprises 5-60% of a compound of the formula (I), in particular for use in the switch elements according to the invention.Type: ApplicationFiled: May 12, 2011Publication date: April 4, 2013Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventor: Michael Junge
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Patent number: 8344163Abstract: There is provided a nitrile compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein m represents in integer of 0 to 4; n represents an integer of 1 to 4; q represents an integer of 0 to 4; Q represents a C1-C4 fluoroalkyl group; Z represents an optionally substituted C2-C6 alkynyl group or a ?N—OR3 group; R1 and R2 independently represent a monovalent C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and A represents an optionally substituted monovalent C1-C6 chain hydrocarbon group, etc.Type: GrantFiled: March 18, 2009Date of Patent: January 1, 2013Assignee: Sumitomo Chemical Company, LimitedInventor: Hiromasa Mitsudera
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Publication number: 20120329696Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.Type: ApplicationFiled: May 24, 2012Publication date: December 27, 2012Inventors: Hugo Robert Germain Denutte, Johan Smets, An Pintens, Jeanne Alfons Van Aken, Freek Annie Camiel Vrielynck
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Patent number: 8183194Abstract: The present invention relates to certain ester and nitrile derivatives of formula (I): wherein one dotted line represents a carbon-carbon single or double bond and the other dotted lines each represent a carbon-carbon single bond; R1 is a hydrogen atom or a methyl group, R2 is a methyl or ethyl group, R3 is a hydrogen atom or a methyl group, R4 is a hydrogen atom or a methyl group or said R4 taken together with the bond between carbon atom 2 and 3 form a cyclopropane; and X represents a CN or a COOR5 group, R5 representing a C1-5 alkyl group; with the compound being in the form of any one of its pure stereoisomers or mixtures thereof. These compounds are useful perfuming ingredients.Type: GrantFiled: March 30, 2010Date of Patent: May 22, 2012Assignee: Firmenich SAInventors: Christian Chapuis, Hervé Pamingle
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Patent number: 8129429Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.Type: GrantFiled: January 12, 2009Date of Patent: March 6, 2012Assignees: Reata Pharmaceuticals, Inc., Trustees of Dartmouth CollegeInventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
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Publication number: 20120029211Abstract: A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphine and a reactant; generating a phosphonium ylide from the phosphonium ylide precursor; reacting the phosphonium ylide precursor with the aldehyde, ketone, or ester to form the olefin and the phosphine oxide which then reenters the cycle. The invention is also directed to a Mitsunobu reaction catalytic in phosphine.Type: ApplicationFiled: April 6, 2010Publication date: February 2, 2012Inventor: Christopher J. O'Brien
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Publication number: 20120004154Abstract: The present invention relates to certain ester and nitrile derivatives of formula (I): wherein one dotted line represents a carbon-carbon single or double bond and the other dotted lines each represent a carbon-carbon single bond; R1 is a hydrogen atom or a methyl group, R2 is a methyl or ethyl group, R3 is a hydrogen atom or a methyl group, R4 is a hydrogen atom or a methyl group or said R4 taken together with the bond between carbon atom 2 and 3 form a cyclopropane; and X represents a CN or a COOR5 group, R5 representing a C1-5 alkyl group; with the compound being in the form of any one of its pure stereoisomers or mixtures thereof. These compounds are useful perfuming ingredients.Type: ApplicationFiled: March 30, 2010Publication date: January 5, 2012Inventors: Christian Chapuis, Hervé Pamingle
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Publication number: 20110309309Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: ApplicationFiled: July 8, 2011Publication date: December 22, 2011Applicant: NOVALED AGInventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
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Patent number: 8057712Abstract: The present invention relates to radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: GrantFiled: November 4, 2008Date of Patent: November 15, 2011Assignee: Novaled AGInventors: Olaf Zeika, Steffen Willmann, Sascha Dorok, Ansgar Werner, Christine Bachmann
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Publication number: 20110207873Abstract: A process for preparing a diaminoacetonitrile which includes reacting by contacting an amine comprising two primary amine groups with a cyanohydrin. The diaminoacetonitrile produced may subsequently be used in the production of polymers and/or as a curing agent for epoxy resins.Type: ApplicationFiled: October 7, 2009Publication date: August 25, 2011Applicant: Huntsman Petrochemical LLCInventors: Ralph M DiGuilio, Matthew W. Forkner, Cheng-Kuang Li
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Patent number: 7981324Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: GrantFiled: April 29, 2008Date of Patent: July 19, 2011Assignee: Novaled AGInventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
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Publication number: 20110021627Abstract: There is provided a nitrile compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein m represents in integer of 0 to 4; n represents an integer of 1 to 4; q represents an integer of 0 to 4; Q represents a C1-C4 fluoroalkyl group; Z represents an optionally substituted C2-C6 alkynyl group or a ?N—OR3 group; R1 and R2 independently represent a monovalent C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and A represents an optionally substituted monovalent C1-C6 chain hydrocarbon group, etc.Type: ApplicationFiled: March 18, 2009Publication date: January 27, 2011Applicant: Sumitomo Chemical Company, LimitedInventor: Hiromasa Mitsudera
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Publication number: 20100237298Abstract: The present invention is concerned with novel compounds derived from polyquinonic ionic compounds and their use in electrochemical generators.Type: ApplicationFiled: June 2, 2010Publication date: September 23, 2010Inventors: Michel Armand, Christophe Michot, Nathalie Ravet
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Publication number: 20100152083Abstract: The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume systems, as well as processes for making and using such, perfume systems and consumer products. The perfume compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.Type: ApplicationFiled: December 16, 2008Publication date: June 17, 2010Inventors: Jose Maria Velazquez, Rafael Trujillo Rosaldo, Philip John Porter, Zerlina Guzdar Dubois, Yoshimi Sunohara, Javier Medina, Michael Green, Hugo Robert Germain Denutte, Jonathan Richard Clare, Stacy Renee Hertenstein
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Publication number: 20100102709Abstract: The present invention relates to radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: ApplicationFiled: November 4, 2008Publication date: April 29, 2010Inventors: Olaf Zeika, Steffen Willmann, Andrea Lux, Horst Hartmann, Sascha Dorok, Ansgar Werner
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Publication number: 20090264657Abstract: Described is the use of specific merocyanine derivatives for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding UV absorber properties.Type: ApplicationFiled: July 19, 2006Publication date: October 22, 2009Inventors: Barbara Wagner, Oliver Reich
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Publication number: 20090175809Abstract: Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is optionally interrupted by —O— or by —NR7—; R4 is a cyano group; or -Q1-R5; Q1 is —COO—; —CONH—; —CO—; —SO2—; or —CONR6—; R5 is C1-C22alkyl; cyclo-C3-C8alkyl; or unsubstituted or C1-C6alkyl-substituted C6-C20aryl; R6 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; R7 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; the cyclohexene radical C is not substituted or substituted by one or more C1-C5alkyl; m is from 3 to 7; n is from 2 to 4; and o is from 2 to 4.Type: ApplicationFiled: February 17, 2009Publication date: July 9, 2009Inventors: Barbara Wagner, Thomas Ehlis, Stefan Muller
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Publication number: 20090069577Abstract: In one embodiment of the present invention, a silicon-based cross-coupling reagent is disclosed which is a highly stable tetraorganosilicon compound allowing for a cross-coupling reaction under mild reaction conditions without using fluoride ions, transition metal promoter, or strong bases, and the residue of the silicon reagent can be recovered and reused. The silicon-based cross-coupling reagent is a silicon compound in which an o-hydroxymethylphenyl group is connected to a silicon atom for intramolecular activation.Type: ApplicationFiled: November 21, 2005Publication date: March 12, 2009Inventors: Yoshiaki Nakao, Tamejiro Hiyama
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Patent number: 7384897Abstract: The present invention is directed to the novel cyclopropanated cyclohexyl ester compounds of the general formula:Type: GrantFiled: March 22, 2007Date of Patent: June 10, 2008Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Franc T. Schiet
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Patent number: 7276575Abstract: A process for refining a crude resin for a resist which is capable of effectively removing by-products such as polymers and oligomers contained within the crude resin. The refining process for the crude resin of resist resin (A) used in a photoresist composition includes at least the resist resin (A) and an acid generator (B) dissolved in a first organic solvent (C1), such that if the concentration of the component (A) in the photoresist composition is labeled X, and the crude resin concentration of the component (A) in a crude resin solution including the crude resin of the component (A) dissolved in a second organic solvent (C2) is labeled Y, then (i) the crude resin solution is prepared so that Y is smaller than X, and (ii) the crude resin solution is subsequently filtered.Type: GrantFiled: January 29, 2004Date of Patent: October 2, 2007Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Hideo Hada, Takeshi Iwai, Miwa Miyairi, Masaaki Muroi, Kota Atsuchi, Hiroaki Tomida
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Patent number: 7064231Abstract: The invention relates to stereoisomerically enriched diamines, to metal complexes comprising these diamines and also to their use in a process for asymmetrically reducing ketones using silanes, in particular polymethylhydrosiloxane, as reducing agents.Type: GrantFiled: August 19, 2003Date of Patent: June 20, 2006Assignee: Bayer AktiengesellschaftInventor: Jürgen Köcher
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Patent number: 6906218Abstract: Disclosed herein are methods for preparing nitrile derivatives and their corresponding amines from 1-,2-,4-trivinylcyclohexane by hydrocyanation, followed by hydrogenation. Also disclosed are novel compounds used in the methods described herein.Type: GrantFiled: December 18, 2002Date of Patent: June 14, 2005Assignee: Invista North America S.a.r.l.Inventors: Alan M. Allgeier, Christian P. Lenges
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Publication number: 20040242905Abstract: Aldehydes containing a difluorooxymethylene bridge, of the general formula IType: ApplicationFiled: May 27, 2004Publication date: December 2, 2004Inventors: Eike Poetsch, Werner Binder, Volker Meyer, Stephen Gurtler, Juergen Eckstein, Michael Schwarz
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Patent number: 6812350Abstract: The present invention relates to a method of making novel dipeptidyl peptidase-IV (“DPP-IV’) inhibitor compounds useful for treating, inter alia, diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, metabolic syndrome (Syndrome X or insulin resistance syndrome), hyperglycemia, impaired glucose tolerance, glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.Type: GrantFiled: June 3, 2003Date of Patent: November 2, 2004Assignee: Pfizer Inc.Inventor: Bernard Hulin
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Publication number: 20040198982Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: ApplicationFiled: August 28, 2003Publication date: October 7, 2004Inventors: Petpihoon Prasit, Christopher Ian Bayly, Joel Stephane Robichaud, W. Cameron Black, Eduardo L. Setti, Robert M. Rydzewski, James T. Palmer
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Publication number: 20040176630Abstract: Alicyclic methacrylate compounds having an oxygen substituent group on their &agr;-methyl group, represented by formula (1), are novel wherein R1 is H or C1-C10 alkyl which may contain a halogen atom, hydroxyl group, ether bond, carbonyl group, carboxyl group or cyano group, and R2 is a monovalent C3-C20 organic group having an alicyclic structure. Polymers prepared from these alicyclic methacrylate compounds have improved transparency, especially at the exposure wavelength of an excimer laser, and improved dry etching resistance. Resist compositions comprising the polymers are sensitive to high-energy radiation, show a high resolution, allow smooth development, lend themselves to micropatterning, and are thus suitable as micropatterning material for VLSI fabrication.Type: ApplicationFiled: March 4, 2004Publication date: September 9, 2004Inventors: Takeru Watanabe, Takeshi Kinsho
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Publication number: 20040127719Abstract: A solid phase reaction template for the production of heterocyclic scaffolds in a reaction media, said solid phase component comprising an alpha-isocyanocarboxylate core compound linked to a solid substrate, the template having the formula: 1Type: ApplicationFiled: March 8, 2002Publication date: July 1, 2004Inventors: Kexin Yang, Boliang Lou
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Publication number: 20040127487Abstract: An agent comprising the benzoic acid of formula (I) 1Type: ApplicationFiled: December 18, 2003Publication date: July 1, 2004Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Kousuke Tani, Kaoru Kobayashi, Takayuki Maruyama
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Publication number: 20040122252Abstract: Disclosed herein are methods for preparing nitrile derivatives and their corresponding amines from 1-,2-,4-trivinylcyclohexane by hydrocyanation, followed by hydrogenation. Also disclosed are novel compounds used in the methods described herein.Type: ApplicationFiled: December 18, 2002Publication date: June 24, 2004Inventors: Alan M. Allgeier, Christian P. Lenges, Rafael Shapiro, Wilson Tam
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Publication number: 20030199708Abstract: The present invention relates to a process for the preparation of compounds of formula I 1Type: ApplicationFiled: April 8, 2003Publication date: October 23, 2003Inventors: Hermann Schneider, Christoph Luthy, Andrew Edmunds
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Publication number: 20030144322Abstract: The invention provides a compound of formula (I): 1Type: ApplicationFiled: October 23, 2002Publication date: July 31, 2003Inventors: Alan P. Kozikowski, Gian Luca Araldi
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Patent number: 6593473Abstract: Improved process for the preparation of granular N-alkylammoniumacetonitrile salts I R2R3N+R1—CR4R5—CN Y− (I) where R1 to R5 are hydrogen or organic radicals, and Y− is a sulfate or hydrogensulfate anion, from an aqueous solution of the compound II R2R3N+R1—CR4R5—CN R6O—SO2—O− (II) where R6 is C1- to C4-alkyl, which comprises evaporating this aqueous solution at a temperature of from 80° C. to 250° C. and a pressure of from 10 mbar to 2 bar to give a melt, then allowing the melt to solidify, where, during or following the evaporation, customary carrier materials and/or auxiliaries can be added, and the resulting solidified compound I is converted into the desired granular form.Type: GrantFiled: September 25, 2001Date of Patent: July 15, 2003Assignee: BASF AktiegesellschaftInventors: Michael Schönherr, Hans-Jürgen Kinder, Klaus Mundinger, Gregor Schürmann
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Publication number: 20030096827Abstract: Compounds having the formula (I), 1Type: ApplicationFiled: March 4, 2002Publication date: May 22, 2003Inventors: Guixue Yu, John Macor, Timothy Herpin, R. Michael Lawrence, George C. Morton, Rejean Ruel, Graham S. Poindexter, Edward H. Ruediger, Carl Thibault
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Publication number: 20030082830Abstract: The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis.Type: ApplicationFiled: June 27, 2002Publication date: May 1, 2003Inventors: Stuart L. Schreiber, Matthew D. Shair, Derek S. Tan, Michael A. Foley, Brent R. Stockwell
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Publication number: 20030013905Abstract: Salts of Cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylate are disclosed herein.Type: ApplicationFiled: June 10, 2002Publication date: January 16, 2003Inventor: Guishu Kris Huang
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Patent number: 6472553Abstract: Compounds of the structure: wherein R1 is H, a C1 to C4 alkyl, or a substituted C1 to C4 alkyl; R2 is H or a cyanoethyl; n is an integer of 1 to 4, and y is 1 or 2, and a method for making the compounds. The compounds are made by reacting acrylonitrile with one or more cycloaliphatic vicinal diamines in the presence of water and a catalytic amount of an acid catalyst having a pKa of −3.0 to 7.5.Type: GrantFiled: April 17, 2002Date of Patent: October 29, 2002Assignee: Air Products and Chemicals, Inc.Inventor: Juan Jesus Burdeniuc
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Publication number: 20020156315Abstract: Compounds of the structure: 1Type: ApplicationFiled: April 17, 2002Publication date: October 24, 2002Inventor: Juan Jesus Burdeniuc
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Patent number: 6462076Abstract: The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease inhibitors useful for the treatment of diseases associated with cysteine proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.Type: GrantFiled: June 1, 2001Date of Patent: October 8, 2002Assignee: Hoffmann-La Roche Inc.Inventors: Tobias Gabriel, Michael Pech, Rosa Maria Rodriguez Sarmiento
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Patent number: 6433212Abstract: Compounds of the structure: wherein R1 is H, a C1 to C4 alkyl, or a substituted C1 to C4 alkyl; R2 is H or a cyanoethyl; n is an integer of 1 to 4, and y is 1 or 2, and a method for making the compounds. The compounds are made by reacting acrylonitrile with one or more cycloaliphatic vicinal diamines in the presence of water and a catalytic amount of an acid catalyst having a PKa of −3.0 to 7.5.Type: GrantFiled: January 31, 2001Date of Patent: August 13, 2002Assignee: Air Products and Chemicals, Inc.Inventor: Juan Jesus Burdeniuc
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Patent number: 6362230Abstract: The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them.Type: GrantFiled: November 21, 2000Date of Patent: March 26, 2002Assignee: Eli Lilly and CompanyInventors: Macklin Brian Arnold, Paul Leslie Ornstein, Dennis Michael Zimmerman, Ana Maria Escribano