Six-membered Alicyclic Ring Containing Patents (Class 558/430)
  • Patent number: 9200237
    Abstract: It is intended to provide a compound and a fragrance composition containing the compound, wherein the compound is useful as a fragrance, has floral and green odors in addition to a strong muguet odor, is stable in an aqueous vehicle, and can be blended with another fragrance to have enhanced freshness and diffusibility. It also is intended to provide 4,8-dimethyl-4,9-decadienenitrile and a fragrance composition containing 4,8-dimethyl-4,9-decadienenitrile.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: December 1, 2015
    Assignee: Kao Corporation
    Inventors: Takashi Aoki, Takahiro Hirose, Shoichi Tahara
  • Publication number: 20150097146
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Patent number: 8951443
    Abstract: Organic semiconducting material comprising at least one matrix material and at least one doping material, wherein the doping material is selected from a [3]radialene compound, and wherein the matrix material is selected from a terphenyldiamine compound, as well as an organic component and a mixture for producing a doped semiconductor layer.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: February 10, 2015
    Assignees: Novaled AG, Sensient Imaging Technologies GmbH
    Inventors: Ansgar Werner, Sascha Dorok, Carsten Rothe, Michael Felicetti, Volker Lischewski, Mirko Tschunarjew
  • Patent number: 8911645
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: December 16, 2014
    Assignee: Novaled AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Patent number: 8853449
    Abstract: Process for the industrial synthesis of the compound of formula (I)
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: October 7, 2014
    Assignee: Les Laboratoires Servier
    Inventors: Samir Zard, Béatrice Sire, Mehdi Boumediene
  • Publication number: 20140150380
    Abstract: Disclosed are compounds of formula (1) and (2) and/or E/E-, E/Z- or Z/Z geometrical isomer forms thereof; wherein R1-R5, R1-R11 and A are defined as in description. The compounds are used as UV absorbers for protecting household products from photolytic and oxidative degradation, as plastic additives, preferably for food and pharmaceutical packaging applications, for preventing photo-degradation of food by incorporation of the compounds of formula (1?) and/or (2?) into transparent food containers, for protection of UV-A sensitive drugs from photo-degradation by incorporation of UV absorber in transparent blister foils or transparent pharmacy containers, as additives for photographic and printing applications, as additives for electronic applications and protecting the ingredients in agriculture applications.
    Type: Application
    Filed: July 19, 2012
    Publication date: June 5, 2014
    Inventors: Barbara Winkler, Dietmar Hueglin, Kai Eichin, Larissa Ehrsam, Xavier Marat, Hervé Richard, ILona Marion Kienzle, Ute Schroeder
  • Publication number: 20140070145
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: November 14, 2013
    Publication date: March 13, 2014
    Applicant: NOVALED AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Patent number: 8617426
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: December 31, 2013
    Assignee: Novaled AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Publication number: 20130330582
    Abstract: A secondary battery includes: a cathode; an anode; and an electrolytic solution including a cyano compound, the cyano compound including a compound represented by R1-O—C(?O)—O—R2 (R1, R2, or both include a cyano-group-containing group), a compound represented by R3-C(?O)—O—R4 (R4 includes the cyano-group-containing group), or both.
    Type: Application
    Filed: June 3, 2013
    Publication date: December 12, 2013
    Inventors: Masayuki Ihara, Tadahiko Kubota
  • Patent number: 8455544
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 4, 2013
    Assignees: Reata Pharmaecuticals, Inc., Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
  • Publication number: 20130083284
    Abstract: The present invention relates to a switch element, which is thermo-responsive and which switches between a less transmissive state for radiant energy and a more transmissive state for radiant energy, and which comprises a liquid-crystalline medium. The invention furthermore relates to the use of the switch element for the regulation of radiant energy flow between interior spaces and the environment and for the regulation of the temperature of interior spaces. The invention furthermore relates to a liquid-crystalline medium, characterised in that it comprises 5-60% of a compound of the formula (I), in particular for use in the switch elements according to the invention.
    Type: Application
    Filed: May 12, 2011
    Publication date: April 4, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventor: Michael Junge
  • Patent number: 8344163
    Abstract: There is provided a nitrile compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein m represents in integer of 0 to 4; n represents an integer of 1 to 4; q represents an integer of 0 to 4; Q represents a C1-C4 fluoroalkyl group; Z represents an optionally substituted C2-C6 alkynyl group or a ?N—OR3 group; R1 and R2 independently represent a monovalent C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and A represents an optionally substituted monovalent C1-C6 chain hydrocarbon group, etc.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: January 1, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiromasa Mitsudera
  • Publication number: 20120329696
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: May 24, 2012
    Publication date: December 27, 2012
    Inventors: Hugo Robert Germain Denutte, Johan Smets, An Pintens, Jeanne Alfons Van Aken, Freek Annie Camiel Vrielynck
  • Patent number: 8183194
    Abstract: The present invention relates to certain ester and nitrile derivatives of formula (I): wherein one dotted line represents a carbon-carbon single or double bond and the other dotted lines each represent a carbon-carbon single bond; R1 is a hydrogen atom or a methyl group, R2 is a methyl or ethyl group, R3 is a hydrogen atom or a methyl group, R4 is a hydrogen atom or a methyl group or said R4 taken together with the bond between carbon atom 2 and 3 form a cyclopropane; and X represents a CN or a COOR5 group, R5 representing a C1-5 alkyl group; with the compound being in the form of any one of its pure stereoisomers or mixtures thereof. These compounds are useful perfuming ingredients.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: May 22, 2012
    Assignee: Firmenich SA
    Inventors: Christian Chapuis, Hervé Pamingle
  • Patent number: 8129429
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: March 6, 2012
    Assignees: Reata Pharmaceuticals, Inc., Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
  • Publication number: 20120029211
    Abstract: A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphine and a reactant; generating a phosphonium ylide from the phosphonium ylide precursor; reacting the phosphonium ylide precursor with the aldehyde, ketone, or ester to form the olefin and the phosphine oxide which then reenters the cycle. The invention is also directed to a Mitsunobu reaction catalytic in phosphine.
    Type: Application
    Filed: April 6, 2010
    Publication date: February 2, 2012
    Inventor: Christopher J. O'Brien
  • Publication number: 20120004154
    Abstract: The present invention relates to certain ester and nitrile derivatives of formula (I): wherein one dotted line represents a carbon-carbon single or double bond and the other dotted lines each represent a carbon-carbon single bond; R1 is a hydrogen atom or a methyl group, R2 is a methyl or ethyl group, R3 is a hydrogen atom or a methyl group, R4 is a hydrogen atom or a methyl group or said R4 taken together with the bond between carbon atom 2 and 3 form a cyclopropane; and X represents a CN or a COOR5 group, R5 representing a C1-5 alkyl group; with the compound being in the form of any one of its pure stereoisomers or mixtures thereof. These compounds are useful perfuming ingredients.
    Type: Application
    Filed: March 30, 2010
    Publication date: January 5, 2012
    Inventors: Christian Chapuis, Hervé Pamingle
  • Publication number: 20110309309
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: July 8, 2011
    Publication date: December 22, 2011
    Applicant: NOVALED AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Patent number: 8057712
    Abstract: The present invention relates to radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: November 15, 2011
    Assignee: Novaled AG
    Inventors: Olaf Zeika, Steffen Willmann, Sascha Dorok, Ansgar Werner, Christine Bachmann
  • Publication number: 20110207873
    Abstract: A process for preparing a diaminoacetonitrile which includes reacting by contacting an amine comprising two primary amine groups with a cyanohydrin. The diaminoacetonitrile produced may subsequently be used in the production of polymers and/or as a curing agent for epoxy resins.
    Type: Application
    Filed: October 7, 2009
    Publication date: August 25, 2011
    Applicant: Huntsman Petrochemical LLC
    Inventors: Ralph M DiGuilio, Matthew W. Forkner, Cheng-Kuang Li
  • Patent number: 7981324
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: July 19, 2011
    Assignee: Novaled AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Publication number: 20110021627
    Abstract: There is provided a nitrile compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein m represents in integer of 0 to 4; n represents an integer of 1 to 4; q represents an integer of 0 to 4; Q represents a C1-C4 fluoroalkyl group; Z represents an optionally substituted C2-C6 alkynyl group or a ?N—OR3 group; R1 and R2 independently represent a monovalent C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and A represents an optionally substituted monovalent C1-C6 chain hydrocarbon group, etc.
    Type: Application
    Filed: March 18, 2009
    Publication date: January 27, 2011
    Applicant: Sumitomo Chemical Company, Limited
    Inventor: Hiromasa Mitsudera
  • Publication number: 20100237298
    Abstract: The present invention is concerned with novel compounds derived from polyquinonic ionic compounds and their use in electrochemical generators.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Inventors: Michel Armand, Christophe Michot, Nathalie Ravet
  • Publication number: 20100152083
    Abstract: The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume systems, as well as processes for making and using such, perfume systems and consumer products. The perfume compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: December 16, 2008
    Publication date: June 17, 2010
    Inventors: Jose Maria Velazquez, Rafael Trujillo Rosaldo, Philip John Porter, Zerlina Guzdar Dubois, Yoshimi Sunohara, Javier Medina, Michael Green, Hugo Robert Germain Denutte, Jonathan Richard Clare, Stacy Renee Hertenstein
  • Publication number: 20100102709
    Abstract: The present invention relates to radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: November 4, 2008
    Publication date: April 29, 2010
    Inventors: Olaf Zeika, Steffen Willmann, Andrea Lux, Horst Hartmann, Sascha Dorok, Ansgar Werner
  • Publication number: 20090264657
    Abstract: Described is the use of specific merocyanine derivatives for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding UV absorber properties.
    Type: Application
    Filed: July 19, 2006
    Publication date: October 22, 2009
    Inventors: Barbara Wagner, Oliver Reich
  • Publication number: 20090175809
    Abstract: Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is optionally interrupted by —O— or by —NR7—; R4 is a cyano group; or -Q1-R5; Q1 is —COO—; —CONH—; —CO—; —SO2—; or —CONR6—; R5 is C1-C22alkyl; cyclo-C3-C8alkyl; or unsubstituted or C1-C6alkyl-substituted C6-C20aryl; R6 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; R7 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; the cyclohexene radical C is not substituted or substituted by one or more C1-C5alkyl; m is from 3 to 7; n is from 2 to 4; and o is from 2 to 4.
    Type: Application
    Filed: February 17, 2009
    Publication date: July 9, 2009
    Inventors: Barbara Wagner, Thomas Ehlis, Stefan Muller
  • Publication number: 20090069577
    Abstract: In one embodiment of the present invention, a silicon-based cross-coupling reagent is disclosed which is a highly stable tetraorganosilicon compound allowing for a cross-coupling reaction under mild reaction conditions without using fluoride ions, transition metal promoter, or strong bases, and the residue of the silicon reagent can be recovered and reused. The silicon-based cross-coupling reagent is a silicon compound in which an o-hydroxymethylphenyl group is connected to a silicon atom for intramolecular activation.
    Type: Application
    Filed: November 21, 2005
    Publication date: March 12, 2009
    Inventors: Yoshiaki Nakao, Tamejiro Hiyama
  • Patent number: 7384897
    Abstract: The present invention is directed to the novel cyclopropanated cyclohexyl ester compounds of the general formula:
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: June 10, 2008
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Franc T. Schiet
  • Patent number: 7276575
    Abstract: A process for refining a crude resin for a resist which is capable of effectively removing by-products such as polymers and oligomers contained within the crude resin. The refining process for the crude resin of resist resin (A) used in a photoresist composition includes at least the resist resin (A) and an acid generator (B) dissolved in a first organic solvent (C1), such that if the concentration of the component (A) in the photoresist composition is labeled X, and the crude resin concentration of the component (A) in a crude resin solution including the crude resin of the component (A) dissolved in a second organic solvent (C2) is labeled Y, then (i) the crude resin solution is prepared so that Y is smaller than X, and (ii) the crude resin solution is subsequently filtered.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: October 2, 2007
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Hideo Hada, Takeshi Iwai, Miwa Miyairi, Masaaki Muroi, Kota Atsuchi, Hiroaki Tomida
  • Patent number: 7064231
    Abstract: The invention relates to stereoisomerically enriched diamines, to metal complexes comprising these diamines and also to their use in a process for asymmetrically reducing ketones using silanes, in particular polymethylhydrosiloxane, as reducing agents.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: June 20, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventor: Jürgen Köcher
  • Patent number: 6906218
    Abstract: Disclosed herein are methods for preparing nitrile derivatives and their corresponding amines from 1-,2-,4-trivinylcyclohexane by hydrocyanation, followed by hydrogenation. Also disclosed are novel compounds used in the methods described herein.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: June 14, 2005
    Assignee: Invista North America S.a.r.l.
    Inventors: Alan M. Allgeier, Christian P. Lenges
  • Publication number: 20040242905
    Abstract: Aldehydes containing a difluorooxymethylene bridge, of the general formula I
    Type: Application
    Filed: May 27, 2004
    Publication date: December 2, 2004
    Inventors: Eike Poetsch, Werner Binder, Volker Meyer, Stephen Gurtler, Juergen Eckstein, Michael Schwarz
  • Patent number: 6812350
    Abstract: The present invention relates to a method of making novel dipeptidyl peptidase-IV (“DPP-IV’) inhibitor compounds useful for treating, inter alia, diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, metabolic syndrome (Syndrome X or insulin resistance syndrome), hyperglycemia, impaired glucose tolerance, glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: November 2, 2004
    Assignee: Pfizer Inc.
    Inventor: Bernard Hulin
  • Publication number: 20040198982
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: August 28, 2003
    Publication date: October 7, 2004
    Inventors: Petpihoon Prasit, Christopher Ian Bayly, Joel Stephane Robichaud, W. Cameron Black, Eduardo L. Setti, Robert M. Rydzewski, James T. Palmer
  • Publication number: 20040176630
    Abstract: Alicyclic methacrylate compounds having an oxygen substituent group on their &agr;-methyl group, represented by formula (1), are novel wherein R1 is H or C1-C10 alkyl which may contain a halogen atom, hydroxyl group, ether bond, carbonyl group, carboxyl group or cyano group, and R2 is a monovalent C3-C20 organic group having an alicyclic structure. Polymers prepared from these alicyclic methacrylate compounds have improved transparency, especially at the exposure wavelength of an excimer laser, and improved dry etching resistance. Resist compositions comprising the polymers are sensitive to high-energy radiation, show a high resolution, allow smooth development, lend themselves to micropatterning, and are thus suitable as micropatterning material for VLSI fabrication.
    Type: Application
    Filed: March 4, 2004
    Publication date: September 9, 2004
    Inventors: Takeru Watanabe, Takeshi Kinsho
  • Publication number: 20040127719
    Abstract: A solid phase reaction template for the production of heterocyclic scaffolds in a reaction media, said solid phase component comprising an alpha-isocyanocarboxylate core compound linked to a solid substrate, the template having the formula: 1
    Type: Application
    Filed: March 8, 2002
    Publication date: July 1, 2004
    Inventors: Kexin Yang, Boliang Lou
  • Publication number: 20040127487
    Abstract: An agent comprising the benzoic acid of formula (I) 1
    Type: Application
    Filed: December 18, 2003
    Publication date: July 1, 2004
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Kousuke Tani, Kaoru Kobayashi, Takayuki Maruyama
  • Publication number: 20040122252
    Abstract: Disclosed herein are methods for preparing nitrile derivatives and their corresponding amines from 1-,2-,4-trivinylcyclohexane by hydrocyanation, followed by hydrogenation. Also disclosed are novel compounds used in the methods described herein.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: Alan M. Allgeier, Christian P. Lenges, Rafael Shapiro, Wilson Tam
  • Publication number: 20030199708
    Abstract: The present invention relates to a process for the preparation of compounds of formula I 1
    Type: Application
    Filed: April 8, 2003
    Publication date: October 23, 2003
    Inventors: Hermann Schneider, Christoph Luthy, Andrew Edmunds
  • Publication number: 20030144322
    Abstract: The invention provides a compound of formula (I): 1
    Type: Application
    Filed: October 23, 2002
    Publication date: July 31, 2003
    Inventors: Alan P. Kozikowski, Gian Luca Araldi
  • Patent number: 6593473
    Abstract: Improved process for the preparation of granular N-alkylammoniumacetonitrile salts I R2R3N+R1—CR4R5—CN Y−  (I) where R1 to R5 are hydrogen or organic radicals, and Y− is a sulfate or hydrogensulfate anion, from an aqueous solution of the compound II R2R3N+R1—CR4R5—CN R6O—SO2—O−  (II) where R6 is C1- to C4-alkyl, which comprises evaporating this aqueous solution at a temperature of from 80° C. to 250° C. and a pressure of from 10 mbar to 2 bar to give a melt, then allowing the melt to solidify, where, during or following the evaporation, customary carrier materials and/or auxiliaries can be added, and the resulting solidified compound I is converted into the desired granular form.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: July 15, 2003
    Assignee: BASF Aktiegesellschaft
    Inventors: Michael Schönherr, Hans-Jürgen Kinder, Klaus Mundinger, Gregor Schürmann
  • Publication number: 20030096827
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: March 4, 2002
    Publication date: May 22, 2003
    Inventors: Guixue Yu, John Macor, Timothy Herpin, R. Michael Lawrence, George C. Morton, Rejean Ruel, Graham S. Poindexter, Edward H. Ruediger, Carl Thibault
  • Publication number: 20030082830
    Abstract: The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis.
    Type: Application
    Filed: June 27, 2002
    Publication date: May 1, 2003
    Inventors: Stuart L. Schreiber, Matthew D. Shair, Derek S. Tan, Michael A. Foley, Brent R. Stockwell
  • Publication number: 20030013905
    Abstract: Salts of Cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylate are disclosed herein.
    Type: Application
    Filed: June 10, 2002
    Publication date: January 16, 2003
    Inventor: Guishu Kris Huang
  • Patent number: 6472553
    Abstract: Compounds of the structure: wherein R1 is H, a C1 to C4 alkyl, or a substituted C1 to C4 alkyl; R2 is H or a cyanoethyl; n is an integer of 1 to 4, and y is 1 or 2, and a method for making the compounds. The compounds are made by reacting acrylonitrile with one or more cycloaliphatic vicinal diamines in the presence of water and a catalytic amount of an acid catalyst having a pKa of −3.0 to 7.5.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: October 29, 2002
    Assignee: Air Products and Chemicals, Inc.
    Inventor: Juan Jesus Burdeniuc
  • Publication number: 20020156315
    Abstract: Compounds of the structure: 1
    Type: Application
    Filed: April 17, 2002
    Publication date: October 24, 2002
    Inventor: Juan Jesus Burdeniuc
  • Patent number: 6462076
    Abstract: The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease inhibitors useful for the treatment of diseases associated with cysteine proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: October 8, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Tobias Gabriel, Michael Pech, Rosa Maria Rodriguez Sarmiento
  • Patent number: 6433212
    Abstract: Compounds of the structure: wherein R1 is H, a C1 to C4 alkyl, or a substituted C1 to C4 alkyl; R2 is H or a cyanoethyl; n is an integer of 1 to 4, and y is 1 or 2, and a method for making the compounds. The compounds are made by reacting acrylonitrile with one or more cycloaliphatic vicinal diamines in the presence of water and a catalytic amount of an acid catalyst having a PKa of −3.0 to 7.5.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: August 13, 2002
    Assignee: Air Products and Chemicals, Inc.
    Inventor: Juan Jesus Burdeniuc
  • Patent number: 6362230
    Abstract: The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: March 26, 2002
    Assignee: Eli Lilly and Company
    Inventors: Macklin Brian Arnold, Paul Leslie Ornstein, Dennis Michael Zimmerman, Ana Maria Escribano