Ortho Fused Patents (Class 560/139)
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Patent number: 11912646Abstract: Provided are aromatic oligoamide foldamers and self-assembled compositions of the same. The aromatic oligoamide foldamers and compositions can form tube-like structures that can form pores in membranes. The pores can be used to transport ions and molecules, such as, for example, cryoprotective agents or therapeutic agents, through the membrane. The tube-like structures exhibit desirable stability at low temperatures.Type: GrantFiled: July 27, 2021Date of Patent: February 27, 2024Assignee: The Research Foundation for The State University of New YorkInventor: Bing Gong
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Publication number: 20150097145Abstract: OLED materials having the formula: T-A(-S-B(-P-B)m-S-A)n-T where A are independently selected rod-shaped, rigid molecular core units, S are independently selected flexible spacer units, B are polymerisable crosslinking groups independently selected, P are spacer groups independently selected, T are independently selected end groups, m are independently selected from values of from 1 to 4, n is equal to I to 3.Type: ApplicationFiled: May 9, 2013Publication date: April 9, 2015Inventor: Gene Carl Koch
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Publication number: 20150031651Abstract: The invention relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma.Type: ApplicationFiled: March 4, 2013Publication date: January 29, 2015Inventors: Mona Moller, Marcel Sandberg, Inger Reidun Aukrust
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Patent number: 8940184Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.Type: GrantFiled: August 30, 2010Date of Patent: January 27, 2015Assignee: MERCK PATENT GmbHInventors: Andreas Taugerbeck, Achim Goetz
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Publication number: 20140350032Abstract: The present invention relates to a compound characterized by the following Formula I: or a pharmaceutically acceptable salt thereof, wherein X, Y, and Z are as described herein. Compounds of the present invention are useful for the treatment of HIV.Type: ApplicationFiled: December 14, 2012Publication date: November 27, 2014Inventors: Nianhe Han, Brian Alvin Johns, Jun Tang
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Patent number: 8765982Abstract: A composition is provided that, when utilized in combination with warfarin, greatly improves the anticoagulant effects of warfarin in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin K1 and has the general formula: where R1 and R4 are hydrogen or acyl, R2 is a saturated or unsaturated alkyl group with up to 6 carbons, and R3 is a saturated or unsaturated alkyl group with up to 20 carbons, or R2 and R3 are part of a cyclic or polycyclic ring system.Type: GrantFiled: September 30, 2010Date of Patent: July 1, 2014Assignee: Marshfield Clinic Health System, Inc.Inventors: David E. Lewis, Michael D. Caldwell
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Publication number: 20140179845Abstract: Provided are compounds and processes of making compounds of the formula: wherein x=4 to 8, R is H, C1 to C4 alkyl, —C(O)OR1 or —OC(O)R1, y=4 to 8, R? is H, C1 to C4 alkyl, and at least one R? is —C(O)OR1 or —OC(O)R1, wherein R1 is a branched C4 to C14 alkyl, and their use in polymer compositions.Type: ApplicationFiled: December 21, 2012Publication date: June 26, 2014Applicant: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: Jihad Mohammed Dakka, Edmund John Mozeleski, Lisa Saunders Baugh, Stephen Zushma
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Publication number: 20140121187Abstract: Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.Type: ApplicationFiled: June 18, 2012Publication date: May 1, 2014Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Young Sik Jung, Chong Kgo Lee, Ihl Young Choi, Hae Soo Kim, Pil Ho Kim, Soo Bong Han, Johan Neyts, Hendrik Jan Thibaut
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Patent number: 8698117Abstract: The present invention relates to compounds represented by the following Formulas (I) and (II), Ring-A of Formulas I and II can be, for example, an aryl group, and Q? and Q?? can each be independently selected from groups, such as, halogen, —OH, —CN, amine groups, amide groups, carboxylic acid ester groups, carboxylic acid groups, alkenyl groups, alkynyl groups, carbonate groups, sulfide groups, and sulfonic acid ester groups. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds, such as represented by Formula II.Type: GrantFiled: August 31, 2011Date of Patent: April 15, 2014Assignee: Transitions Optical, Inc.Inventors: Meng He, Anil Kumar, Darrin R. Dabideen
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Publication number: 20130277609Abstract: A compound represented by formula (1), a liquid crystal composition, a liquid crystal display device are described. In formula (1), for example, the ring A1 and the ring A4 are phenylene or cyclohexylene; Z1, Z2, Z3 and Z4 are a single bond or alkylene having 1 to 6 carbons; L1 is a single bond; s and t are 0; and P1, P2, P3 and P4 are a polymerizable group.Type: ApplicationFiled: December 23, 2012Publication date: October 24, 2013Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: YASUYUKI GOTO, MAIKO MATSUKUMA, JUNICHI YAMASHITA
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Patent number: 8524939Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.Type: GrantFiled: August 24, 2011Date of Patent: September 3, 2013Assignee: Chirogate International Inc.Inventors: Shih-Yi Wei, Min-Kuan Hsu, Ming-Kun Hsu
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Publication number: 20130053581Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.Type: ApplicationFiled: August 24, 2011Publication date: February 28, 2013Inventors: Shih-Yi WEI, Min-Kuan Hsu, Ming-Kun Hsu
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Publication number: 20120182516Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.Type: ApplicationFiled: August 30, 2010Publication date: July 19, 2012Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Andreas Taugerbeck, Achim Goetz
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Publication number: 20120129736Abstract: A highly oxidized form of graphene oxide and methods for production thereof are described in various embodiments of the present disclosure. In general, the methods include mixing a graphite source with a solution containing at least one oxidant and at least one protecting agent and then oxidizing the graphite source with the at least one oxidant in the presence of the at least one protecting agent to form the graphene oxide. Graphene oxide synthesized by the presently described methods is of a high structural quality that is more oxidized and maintains a higher proportion of aromatic rings and aromatic domains than does graphene oxide prepared in the absence of at least one protecting agent. Methods for reduction of graphene oxide into chemically converted graphene are also disclosed herein. The chemically converted graphene of the present disclosure is significantly more electrically conductive than is chemically converted graphene prepared from other sources of graphene oxide.Type: ApplicationFiled: May 14, 2010Publication date: May 24, 2012Applicant: WILLIAM MARSH RICE UNIVERSITYInventors: James M. Tour, Dmitriy V. Kosynkin
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Publication number: 20120126185Abstract: The present invention relates to compounds represented by the following Formulas (I) and (II), Ring-A of Formulas I and II can be, for example, an aryl group, and Q? and Q?? can each be independently selected from groups, such as, halogen, —OH, —CN, amine groups, amide groups, carboxylic acid ester groups, carboxylic acid groups, alkenyl groups, alkynyl groups, carbonate groups, sulfide groups, and sulfonic acid ester groups. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds, such as represented by Formula II.Type: ApplicationFiled: August 31, 2011Publication date: May 24, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventors: Meng He, Anil Kumar, Darrin R. Dabideen
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Publication number: 20120092608Abstract: Provided is a polymerizable compound with large solubility in a liquid crystal composition and high reactivity irradiated by ultraviolet in the longer wavelength range. Provided is a liquid crystal composition that satisfies at least one of characteristics such as high maximum temperature of a nematic phase, low minimum temperature of a nematic phase, small viscosity, suitable optical anisotropy, large negative dielectric anisotropy, large specific resistance, high stability to ultraviolet light and high stability to heat, or that is suitably balanced between at least two of the characteristics.Type: ApplicationFiled: May 7, 2010Publication date: April 19, 2012Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: Maiko Ito, Keiji Kimura, Norikatsu Hattori, Eriko Saegusa
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Patent number: 8048496Abstract: The purpose the invention is to provide a polymerizable liquid crystal compound which has an excellent solubility with other compounds, a high homeotropic property, and a spirobiindan-backbone, and a liquid crystal composition comprising this compound. The purpose is attained with a polymerizable liquid crystal compound represented by Formula (1). A polymer which is excellent in many characteristics can be obtained from this compound and a formed body having optical anisotropy, produced from this polymer can be obtained. In Formula (1), G is a single bond or oxygen; R is hydrogen, methyl (Me) or a group represented by Formula (a), wherein at least two of R are groups represented by Formula (a); P is a polymerizable group represented by any of Formula (P1) to Formula (P8). In Formula (a), a desirable A is 1,4-cyclohexylene or 1,4-phenylene; Z is a bonding group; m is an integer of 0 to 3; X0 is a single bond or alkylene; Z0 is a single bond, —O—, —OCO—, or —OCOO—; X is a single bond or alkylene.Type: GrantFiled: September 25, 2009Date of Patent: November 1, 2011Assignee: JNC CorporationInventors: Maiko Itoh, Yoshiharu Hirai, Junichi Inagaki, Daisuke Ootsuki
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Publication number: 20110263539Abstract: The present invention provides the use of pelorol analogs of Formula, (I) and pharmaceutical compositions thereof as modulators of SHIP 1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.Type: ApplicationFiled: June 21, 2007Publication date: October 27, 2011Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond Andersen, Matthew Nodwell, Alice Mui
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Patent number: 8043789Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula. Also, the present invention provides a photoresist composition comprising 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to 15 weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 10 to 5000 weight parts of an organic solvent. In the formula, n is 0 or 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, z is 0, 1, 2, 3 or 4, R, R? and R? are independently hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms, and R?? is a hydrogen atom or hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms.Type: GrantFiled: December 17, 2008Date of Patent: October 25, 2011Assignee: Dongjin Semichem Co., Ltd.Inventors: Jae-Woo Lee, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
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Publication number: 20110245341Abstract: The present invention is directed to a process for producing non-genotoxic Diacetylrhein (Diacerein), comprising: i) transformation of raw Diacerein (or raw Rhein), into a water-soluble salt; ii) adsorption of the salt Diacerein (or Rhein) solution on a hydrophobic resin; iii) washing with an appropriate solvent to eliminate the impurities (in particular the genotoxic impurities); iv) elution to recover Diacereinor Rhein; v) if the process is applied to Rhein, its transformation to Diacerein by acetylation; vi) acidification of purified Diacerein and its recovery, and drying. The invention is also directed to non-genotoxic Diacerein obtained by the process of the invention, in which the total content of genotoxic impurities is below 1 ppm, and suitable for the preparation of pharmaceutical formulations, in particular capsules, for human and veterinary use, in agreement with the current Health Authorities request.Type: ApplicationFiled: November 3, 2009Publication date: October 6, 2011Applicant: EVULTIS SAInventors: Alessandro Mazzola, Silvia Moiana
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Patent number: 7985455Abstract: The compound of the present invention is represented by the formula (1). In the formula (1), R1 and R2 are hydrogen, fluorine, chlorine, methyl or ethyl; X1 and X2 are hydrogen, fluorine, methyl or trifluoromethyl; Z1 and Z2 are a single bond, —COO—, —OCO—, —CH?CH—COO—, —OCO—CH?CH—, —CH2CH2—COO—, —OCO—CH2CH2—, —CH2O—, —CONH—, —(CH2)4—, —CH2CH2— or —C?C—; Z3 and Z4 are a single bond or —O—; A1 and A2 are 1,4-cyclohexylene, 1,4-phenylene, 1,3-phenylene, pyridin-2,5-diyl, pyrimidin-2,5-diyl, naphthalen-2,6-diyl or tetrahydronaphtlane-2,6-diyl; and Y1 and Y2 are alkylene having from 2 to 20 carbon atoms.Type: GrantFiled: May 7, 2010Date of Patent: July 26, 2011Assignees: JNC Corporation, Chisso Petrochemical CorporationInventors: Junichi Inagaki, Tomohiro Yano, Daisuke Ootsuki, Maiko Ito, Ryushi Shundo
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Publication number: 20110130589Abstract: The invention relates to a process for the preparation of bis(fluoroalkyl)phosphinic acid and/or fluoroalkylphosphonic acid by reaction of, monofluoroalkyltetrafluorophosphorane bis(fluoroalkyl)trifluorophosphorane or tris(fluoroalkyl)difluorophosphorane with water.Type: ApplicationFiled: July 8, 2009Publication date: June 2, 2011Applicant: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Nikolai Mykola Ignatyev, Dana Bejan, Helge Willner
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Publication number: 20100308265Abstract: This invention relates to liquid crystal compositions, and polymer networks and articles comprising the compositions. The compositions comprise at least one compound of the group of compounds represented by the structures of each of the following Formulas (IV), (V) and (VI), as defined herein. A process for making the composition is also provided.Type: ApplicationFiled: June 8, 2009Publication date: December 9, 2010Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventor: MARC B. GOLDFINGER
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Publication number: 20100240748Abstract: The present invention relates to novel tetrahydronaphthalen-2-ol derivatives, to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular to their use for the manufacture of a medicament for the prevention or treatment of lower urinary tract symptoms, benign prostate hyperplasia, prostate cancer, hot flushes, anxiety, depression, breast cancer, medullary thyroid carcinoma, ovarian cancer, inflammatory bowel disease, arthritis, endometriosis, and colon cancer.Type: ApplicationFiled: March 11, 2010Publication date: September 23, 2010Inventors: Herman Thijs Stock, Neeltje Miranda Teerhuis, Gerrit Herman Veeneman
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Publication number: 20100173991Abstract: The aim of the invention to provide a less complex method for the production of A-ring aromatized acetyl minocyclines of the formula (I), wherein R1 to R5=acetyl and/or H, which can also be used on an industrial scale, is achieved in that minocycline hydrochloride is reacted with acetanhydride in the presence of a proton catcher, the reaction product is subjected to chromatographic filtration using a carrier material and an eluant, the eluant is distilled off, and the product is subsequently cleaned by recrystallization.Type: ApplicationFiled: June 25, 2008Publication date: July 8, 2010Inventors: Peter Lorenz, Peter Kreutzmann, Fritz Rothe, Jens Martens-Lobenhoffer, Harry Schmidt, Gerald Wolf
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Publication number: 20100113643Abstract: The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions.Type: ApplicationFiled: April 9, 2008Publication date: May 6, 2010Applicant: DESIGNER MOLECULES, INC.Inventor: Stephen M. Dershem
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Publication number: 20080293812Abstract: Pamoic acid or its derivatives of formula (I) are used to treat diseases characterized by deposits of amyloid aggregates.Type: ApplicationFiled: November 1, 2007Publication date: November 27, 2008Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S. P.A.,Inventors: Maria Grazia Gallo, Maria Grazia Cima, Fabrizio Giorgi, Maria Ornella Tinti, Paola Piovesan, Orlando Ghirardi
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Patent number: 6958412Abstract: A method for synthesizing a pentafluorophenyl acrylate polymer includes bulk polymerizing a pentafluorophenyl acrylate monomer in the presence of a free radical initiator. The reactant mixture was subjected to an ultrasonication treatment, so that the mixing of the initiator and the monomer is enhanced; carried out the bulk polymerization at 25-99° C. for a period of time, and at 100-200° C. under a vacuum pressure for another period of time to complete the bulk polymerization, so that residue amounts of the initiator, unreacted monomer and oligomer of the monomer are reduced in the resulting reaction mixture.Type: GrantFiled: September 25, 2003Date of Patent: October 25, 2005Assignee: Chung-Shan Institute of Science & TechnologyInventors: Shean-Jeng Jong, Chang-Chih Lin, Yu-Sheng Lin
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Patent number: 6953813Abstract: The use of racemic or optically active compounds represented by formula (I) and the salts thereof wherein R is H or CH3 for the preparation of pharmaceutical compositions for the therapy of ophthalmic disorders.Type: GrantFiled: July 26, 2000Date of Patent: October 11, 2005Assignee: Chiesi Farmaceutici S.p.A.Inventors: Stefano Bongrani, Roberta Razzetti, Paolo Chiesi
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Patent number: 6916946Abstract: Disclosed is a novel acid halide derivative represented by Formula (I): wherein X and Y may be the same or different and are each a halogen atom; and R is a lower alkyl group. By cyclizing the acid halide derivative of Formula (I) in the presence of a catalyst, an indanonecarboxylic acid ester represented by Formula (VI): wherein X and R are as defined above, is produced. Such indanonecarboxylic acid esters are useful as intermediates for insecticides.Type: GrantFiled: March 11, 2004Date of Patent: July 12, 2005Assignee: Daicel Chemical Industries, Ltd.Inventors: Satoru Nose, Kieko Sano, Syu-ichi Yamagiwa, Takeshi Hamatani
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Patent number: 6875895Abstract: Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R22 each independently represent a hydrogen atom, a halogen atom, cyano group, nitro group, etc., and at least one of R1-R20 is a halogen atom, etc. The arene compound has sufficient solubility in an organic solvent and excellent reactivity.Type: GrantFiled: August 20, 2002Date of Patent: April 5, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Takahiro Ueoka, Hideyuki Ikehira, Yoshiaki Tsubata
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Patent number: 6696436Abstract: The invention provides B-ring expanded estra-1,3,5(10)-triene compounds of general formula (1) which modulate the polymerization of tubulin and/or the depolymerization of microtubules. The compounds have anti-angiogenic and anti-tumor activity. The invention also provides methods of preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirable angiogenesis. The compounds of the invention are also expected to have utility as research tools.Type: GrantFiled: August 16, 2002Date of Patent: February 24, 2004Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Ernest Hamel, Mark S. Cushman
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Patent number: 6593490Abstract: Monomers containing the benzocyclobutenone moiety, and a method of preparing same, are provided.Type: GrantFiled: September 13, 2002Date of Patent: July 15, 2003Assignee: Avery Dennison CorporationInventors: Kai Li, Yukihiko Sasaki, Prakash Mallya, Pradeep Iyer
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Publication number: 20030083377Abstract: The present invention discloses the use of ER&bgr;-selective ligands for production of medicaments for regulating fertility without additional use of a progestin.Type: ApplicationFiled: February 27, 2002Publication date: May 1, 2003Applicant: SCHERING AKTIENGESELLSCHAFTInventors: Christa Hegele-Hartung, Karl-Heinrich Fritzemeier, Hiroshi Yamanouchi, Olaf Peters, Dirk Kosemund, Gerd Mueller, Ingo Tornus, Gerd Schubert
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Patent number: 6495680Abstract: Helical oligomer and polymer compositions that form nanotubes are described. The compositions comprise a plurality of aromatic substituents linked by at least one amide group. The compositions have a curved backbone due to intramolecular hydrogen bonds that rigidify the amide linkage of each amide group to each aromatic substituent and due to an interaction between the aromatic substituents such that the curved backbone is stabilized. The helical compositions are formed by ridigifying the amide group, which is flanked on each side by the aromatic substituents, by introducing intramolecular hydrogen bonds into a linkage between the amide group and each aromatic substituent such that the compositions fold into a helical shape when the amide linkages are meta to each other.Type: GrantFiled: March 24, 2000Date of Patent: December 17, 2002Assignee: The University of ToledoInventor: Bing Gong
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Publication number: 20020110530Abstract: An antimicrobial compound, composition containing such compound, and method of use of the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and one or more essential antimicrobial compounds including non-halogenated naphthol compounds.Type: ApplicationFiled: December 20, 2001Publication date: August 15, 2002Inventors: David Scott Harper, Robert A. Coburn, Andre Soshinsky, Constantine Georgiades, Marianne D. Huntley
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Publication number: 20010037025Abstract: The present invention provides novel compounds of formula I 1Type: ApplicationFiled: May 23, 2001Publication date: November 1, 2001Inventors: Anthony Murray, John Bondo Hansen
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Patent number: 6288266Abstract: Acrylates having a high degree of halogenation, as well as polymers that include one or more mer units derived from such acrylates provide materials having tailorable optical and physical properties. The polymers find utility particularly in optical devices including optical waveguides and interconnecting devices.Type: GrantFiled: August 24, 1999Date of Patent: September 11, 2001Assignee: 3M Innovative Properties CompanyInventors: George G. I. Moore, Fred B. McCormick, Mita Chattoraj, Elisa M. Cross, Junkang Jacob Liu, Ralph R. Roberts, Jay F. Schulz
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Publication number: 20010018539Abstract: The invention relates to novel anthracene compounds useful in the treatment of allergic, inflammatory conditions, tumor conditions and therapeutic compositions containing such compounds. The compounds of the present invention are 9-acyloxy-substituted 1,5-dichloroanthracene or analogs thereof.Type: ApplicationFiled: March 5, 2001Publication date: August 30, 2001Inventors: Hsu-Shan Huang, Kung-Yuan Lee, Chang-Hsin Shi, Hsien-Chin Hsu
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Patent number: 6252104Abstract: A naphthol derivative represented by the general formula (I), [wherein Y and Y′ indicate —(CONH)n—X or —COR; X is a phenyl group, a naphthyl group, an anthraquinonyl group, a benzimidazolonyl group or a carbazolyl group; R is a hydroxyl group, an alkoxy group having 1 to 6 carbon atoms, a halogen atom, a benzyloxy group, a phenyloxy group or a phenacyloxy group; R2 is a hydrogen atom, an alkaline metal, an alkyl group having 1 to 6 carbon atoms, an acyl group having 1 to 6 carbon atoms or a phenylalkyl group; Z is a group selected from the group consisting of a hydrogen atom, a halogen atom, a nitro group, a nitroso group and an amino group (Z may be substituted on any ring of the naphthalene ring); and n is an integer of 1 or 2; provided that R2 and Z do not simultaneously indicate a hydrogen atom when both R simultaneously indicate a hydroxyl group], and a process for producing the same.Type: GrantFiled: December 12, 1996Date of Patent: June 26, 2001Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Shigeru Ito, Kenji Minami, Masaya Kitayama
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Patent number: 6066757Abstract: A stilbene compound is disclosed which has the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each stand for hydrogen, an alkyl group or an acyl group and Ar.sup.1 and Ar.sup.2 each stand for a monovalent homocyclic aromatic group. The stilbene compound may be incorporated into a photoconducting layer of an electrophotographic photoconductor as a charge transporting material. A process for the production of the stilbene compound is also disclosed.Type: GrantFiled: January 20, 1998Date of Patent: May 23, 2000Assignee: Ricoh Company, Ltd.Inventors: Chiaki Tanaka, Masaomi Sasaki, Tomoyuki Shimada
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Patent number: 6005137Abstract: Acrylates having a high degree of halogenation, as well as polymers that include one or more mer units derived from such acrylates provide materials having tailorable optical and physical properties. The polymers find utility particularly in optical devices including optical waveguides and interconnecting devices.Type: GrantFiled: June 10, 1997Date of Patent: December 21, 1999Assignee: 3M Innovative Properties CompanyInventors: George G. I. Moore, Fred B. McCormick, Mita Chattoraj, Elisa M. Cross, Junkang Jacob Liu, Ralph R. Roberts, Jay F. Schulz
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Patent number: 5942641Abstract: The present invention provides a novel fluorenone derivatives represented by the formula: ##STR1## wherein R.sup.a -R.sup.g are defined in the specification, and a method for repairing and protecting central or peripheral nerve degeneration comprising use of a fluorenone derivative represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 p and q are as defined in the specification as an active component.Type: GrantFiled: February 7, 1995Date of Patent: August 24, 1999Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Tatsuyoshi Tanaka, Yohji Sakurai, Nobutaka Fujisawa, Osamu Hongoh, Takao Nishi
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Patent number: 5942648Abstract: Naphthalene derivatives of the fomula I ##STR1## in which: R.sup.1 is an alkyl or alkenyl radical which is unsubstituted, monosubstituted by CH or CF.sub.3 or monosubstituted by halogen and has 1 to 15 carbon atoms, it also being possible for one or more CH.sub.2 groups in these radicals to be replaced, in each case independently of one another, by --O--, --S--, ##STR2## --CO--, --CO--O--, --O--CO-- or --O--CO--O-- in such a manner that oxygen atoms are not linked directly to one another, ##STR3## m is 0, 1 or 2, n is 0 or 1, wherem+n is 1 or 2,Z.sup.1 and Z.sup.2 are each, independently of one another, --CH.sub.2 CH.sub.2 --, --C.tbd.C-- or a single bond,L.sup.1 and L.sup.2 independently of one another, are H or F,x is an alkyl or alkoxy radical which is unsubstituted, monosubstituted by CN or CF.sub.3 or substituted bi halogen and has 1 to 15 carbon atoms, or is OH, CN, SCN, OCN, NCS or Q--Y,whereQ is a single bond, (CF.sub.2).sub.r or O(CF.sub.2).sub.Type: GrantFiled: March 4, 1997Date of Patent: August 24, 1999Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: David Coates, Mark Goulding, Simon Greenfield, Volker Reiffenrath, Reinhard Hittich, Herbert Plach
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Patent number: 5811421Abstract: The present invention provides compounds of formula ##STR1## wherein R.sup.1 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOC.sub.6 H.sub.5, --OCO(C.sub.1 -C.sub.6 alkyl), or --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl);R.sup.2 is C.sub.1 -C.sub.6 alkyl or C.sub.5 -C.sub.7 cycloalkyl which is optionally substituted with 1 to 3 substitutents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, amino, nitro, and halo;X is --CH(OH)-- or --CH.sub.2 --;M is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;n is 2 or 3; andR.sup.3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof. Also provided are methods of using the compounds of the present invention for the treatment of various medical indications associated with post-menopausal syndrome, uterine fibroid disease, endometriosis, and aortal smooth muscle cell proliferation.Type: GrantFiled: July 16, 1996Date of Patent: September 22, 1998Assignee: Eli Lilly and CompanyInventors: Jeffrey Alan Dodge, Kennan Joseph Fahey, Charles David Jones, Charles Willis Lugar, III
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Patent number: 5792762Abstract: The invention provides dihydronaphthofluorene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions.Type: GrantFiled: September 19, 1997Date of Patent: August 11, 1998Assignee: Eli Lilly and CompanyInventors: Henry Uhlman Bryant, Thomas Alan Crowell, Charles David Jones
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Patent number: 5750577Abstract: Novel medicinally-useful compounds are provided herein. These compounds include isomeric cyclic tetramers of formaldehyde and 1-naphthol, and the derivatives or analogues of such cyclic tetramers, and linear oligomers of chromotropic acid, or its derivatives or analogues with naphthalene.Type: GrantFiled: December 5, 1996Date of Patent: May 12, 1998Assignee: Seabright Corporation LimitedInventor: Paris Georghiou
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Patent number: 5739374Abstract: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.Type: GrantFiled: February 14, 1997Date of Patent: April 14, 1998Assignee: BASF AktiengesellschaftInventors: Bernd Janssen, Hans-Heiner Wuest
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Patent number: 5705533Abstract: 10-thio-substituted 1,8-dihydroxy-9(10H) anthracenones, therapeutic compositions containing at least one of the 10-thio-substituted 1,8-dihydroxy-9(10H) anthracenones of the invention and methods of treating inflammatory conditions are provided.Type: GrantFiled: June 7, 1995Date of Patent: January 6, 1998Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Klaus Muller, Hsu-Shan Huang, Wolfgang Wiegrebe
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Patent number: 5670698Abstract: A one pot process is provided in which a Mannich base of the formula 5 is reacted with acetic anhydride to produce a diacetate derivative. Without any intermediate isolation, the derivative is hydrogenated to produce a reaction mixture containing 1-acetoxy-2-methylnaphthalene which is readily precipitated from the reaction mixture by addition of water.Type: GrantFiled: August 19, 1996Date of Patent: September 23, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Mu-Ill Lim, Yuh-Guo Pan, Linas Stasaitis, James Anderson