Carbamic Acid Patents (Class 560/157)
  • Publication number: 20120238661
    Abstract: The invention provides compounds containing the ring-opening products of ethylenically unsaturated cyclic carbonates for use in preparing hydrogel polymers, as well as methods for their preparation. A preferred method of the invention includes the reaction of nucleophilic compounds containing Si, F, N or O atoms, or combinations thereof, or latent moieties in the form of unsaturated or hydroxylated functional groups, with ethylenically unsaturated glycerol carbonate derivatives. The compounds and hydrogel polymers are useful for the preparation of contact lenses.
    Type: Application
    Filed: January 13, 2012
    Publication date: September 20, 2012
    Applicant: Cognis IP Management GmbH
    Inventors: Ramesh Iyer, Peter McKenna, Mark Smallridge, Melissa Matthews, Anbazhagan Natesh
  • Patent number: 8252850
    Abstract: Novel crosslink agents are described that provide for the copolymerization of at least one hydrophilic monomer with at least one lens monomer typically used to prepare materials for ophthalmic lenses. The new crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: August 28, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: Ivan M. Nunez, Joseph A. McGee, David E. Seelye
  • Publication number: 20120215007
    Abstract: This disclosure relates to methods for preparing an enantiomerically enriched N-carboxyanhydride of an amino alpha acid of the formula (IIIa) or (IIIb): from a compound of the formula (IIa) or (IIb), respectively: wherein R1, R2, and R3 are as defined in the disclosure.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 23, 2012
    Applicant: SANOFI
    Inventors: Antony BIGOT, Maxime LAMPILAS
  • Patent number: 8232315
    Abstract: The invention is directed to a method of treating addiction to drugs of abuse in a subject, comprising administering a therapeutically effective amount of a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: July 31, 2012
    Assignee: SK Biopharmaceuticals Co., Ltd.
    Inventors: Sung James Lee, Susan Marie Melnick
  • Publication number: 20120183619
    Abstract: The present invention is directed to triclosan derivatives and nanoparticles comprising said derivatives together with an organic or an inorganic carrier. The present invention is also directed to uses of the triclosan nanoparticles for preventing or inhibiting bacterial growth.
    Type: Application
    Filed: October 31, 2011
    Publication date: July 19, 2012
    Applicant: BAR ILAN UNIVERSITY
    Inventors: Jean Paul LELLOUCHE, Igor MAKAROVSKY, Yonit BOGUSLAVSKY, Ehud BANIN, Jonatan LELLOUCHE
  • Publication number: 20120148952
    Abstract: A radiation-sensitive resin composition includes a compound, a resin and a radiation-sensitive acid generator. The compound has a structure in which a group represented by a following formula (1) is bound to a nitrogen atom. The resin has an acid-dissociative dissolution-controlling group and has a property such that alkali solubility of the resin increases by an action of an acid. In the formula (1), Y is a monovalent group having 5 to 20 carbon atoms, and “*” represents a bonding hand with the nitrogen atom. In the formula (i), R1, R2 and R3 each independently represent a linear or branched alkyl group having 1 to 4 carbon atoms or a monovalent alicyclic hydrocarbon group having 4 to 12 carbon atoms, or R1 and R2 are linked with each other to form a bivalent alicyclic hydrocarbon group, and “*” represents a bonding hand with the oxygen atom.
    Type: Application
    Filed: January 17, 2012
    Publication date: June 14, 2012
    Applicant: JSR Corporation
    Inventors: Kazuo NAKAHARA, Mitsuo SATO
  • Publication number: 20120148595
    Abstract: The present invention relates to GABA-linked anthracycline-lipid conjugates and to methods of using the conjugates to treat cancer. Methods for making the GABA-linked anthracycline lipid conjugates are also provided.
    Type: Application
    Filed: March 11, 2010
    Publication date: June 14, 2012
    Applicant: Luitpold Pharmaceuticals, Inc.
    Inventors: Charles S. Swindell, Glenn G. Fegley, Hema M. Sundar, Richard Lawrence
  • Publication number: 20120129220
    Abstract: The present invention is aimed to provide a method for industrially producing a useful substance (protein etc.) utilizing a bacterium such as Escherichia coli in the presence of a surfactant and a surfactant to be used in this method for producing a useful substance. The present invention is a method for producing a useful substance into a culture solution by secretion by a bacterium in the culture solution, wherein the culture solution contains a surfactant (A), and a dried cell density based on the volume of the culture solution is 1.5 to 500 g/L. More preferably, the present invention is a method for producing a useful substance wherein the surfactant (A) is at least one agent selected from the group consisting of an amphoteric surfactant, an anionic surfactant, and a nonionic surfactant having an HLB value of 0 to 13.
    Type: Application
    Filed: May 26, 2010
    Publication date: May 24, 2012
    Applicant: Sanyo Chemical Industries, Ltd.
    Inventors: Fusamitsu Yanagihara, Shunichiro Yamaguchi
  • Patent number: 8178703
    Abstract: Methods to convert biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: May 15, 2012
    Assignee: Battelle Memorial Institute
    Inventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
  • Patent number: 8173849
    Abstract: A (?)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: May 8, 2012
    Assignee: Signature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Publication number: 20120059186
    Abstract: A composition comprising at least one curable compound (I) advantageously having a refractive index Formula (I) of at least 1.60 and obtained from the reaction of A at least one aromatic polyisocyanate, B at least one monofunctional alcohol or amine, C at least one further monofunctional alcohol or amine different from B, D at least one diol or diamine, and E optionally a hydroxyl group containing (meth)acrylate, the compound (I) comprising at least one curable functional group selected from the group consisting of carbon-carbon double bonds and epoxy groups.
    Type: Application
    Filed: May 11, 2010
    Publication date: March 8, 2012
    Inventors: Zhikai Wang, Marcus Lee Hutchins
  • Publication number: 20120053359
    Abstract: The invention relates to the production of carbamates in a single reactor (one-pot) using solid catalysts, involving the reaction between at least one nitro compound, an organic carbonate of formula (OR)(OR?)C?O, a gas selected from hydrogen gas and a mixture of gases containing hydrogen and hydrogen precursor compounds, and a catalyst that has at least one metallic oxide and can also contain an element of groups 8, 9, 10 and 11 of the periodical table. The carbonates obtained can be transformed into their corresponding isocyanates.
    Type: Application
    Filed: September 9, 2011
    Publication date: March 1, 2012
    Inventors: Avelino CORMA CANOS, Hermenegildo GARCÍA GÓMEZ, Raquel JUAREZ MARÍN
  • Publication number: 20120029144
    Abstract: The present invention relates to new, urethane-group-containing polyisocyanates based on aliphatic and/or cycloaliphatic diisocyanates, and to their use.
    Type: Application
    Filed: July 28, 2011
    Publication date: February 2, 2012
    Applicant: BASF SE
    Inventors: Oihana Elizalde, Frederic Lucas, Angelika Maria Steinbrecher, Lydie Tuchbreiter
  • Patent number: 8106141
    Abstract: Reaction products prepared from reactants including: (a) at least one compound of structural Formula (I): wherein R1 is selected from aryl and heteroaryl; X is selected from a direct bond, —O—, —S—, —NH—, alkylene, cycloalkylene, heterocyclylene, arylene, alkarylene, and heteroarylene; Y is a substituted alkylene group having at least two contiguous carbon atoms and which can be interrupted by one or more —O—, —S—, or —NH— moieties as defined herein, wherein the alkylene group of Y has substituents independently selected from —OH, —NH2, —SH, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or two hydrogen atoms on the same carbon atom of Y are replaced by carbonyl, and wherein at least two substituents of Y are each independently selected from —OH, —NH2, and —SH, as defined herein; and (b) at least one isocyanate functional material.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: January 31, 2012
    Assignee: Henkel Corporation
    Inventors: Anthony F. Jacobine, Andrew Messana, David M. Glaser, Steven Thomas Nakos
  • Publication number: 20120010425
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Application
    Filed: August 11, 2011
    Publication date: January 12, 2012
    Applicant: XENOPORT, INC.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Publication number: 20110311583
    Abstract: (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.
    Type: Application
    Filed: November 10, 2009
    Publication date: December 22, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Jayaprakash K. Narayanannair, Martin Maier, Laxman Eltepu
  • Publication number: 20110245477
    Abstract: The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.
    Type: Application
    Filed: February 8, 2011
    Publication date: October 6, 2011
    Applicants: Trustees of Boston College, Massachusetts Institute of Technology
    Inventors: Amir H. Hoveyda, Simon J. Meek, Robert V. O'Brien, Josep Llaveria Cros, Richard R. Schrock
  • Publication number: 20110237758
    Abstract: The present invention provides a urethane-forming reaction catalyst which is useful for catalyzing a reaction between an isocyanate compound, in particular, an aliphatic isocyanate and a hydroxyl group-containing compound to form a urethane material, which does not affect the performance of the urethane material, and which can be easily removed from the resulting urethane material, and a method for producing a metal compound-free urethane material using the urethane-forming reaction catalyst. The catalyst of the present invention is a urethane-forming reaction catalyst for producing a urethane material by allowing a hydroxyl group-containing compound to react with an isocyanate compound, the catalyst being at least one solid acid catalyst selected from the group consisting of a (A) composite metal oxide in which a metal oxide (A-2) or a non-metal compound (A-3) is carried on a surface of a metal oxide carrier (A-1), (B) zeolite, and a (C) heteropoly acid.
    Type: Application
    Filed: September 16, 2009
    Publication date: September 29, 2011
    Applicant: DIC Corporation
    Inventors: Hironobu Oki, Yasuyuki Watanabe, Youichi Abe
  • Publication number: 20110224295
    Abstract: A crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug and methods of preparing a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug, and methods of using a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug are provided.
    Type: Application
    Filed: December 7, 2010
    Publication date: September 15, 2011
    Applicant: XenoPort, Inc.
    Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
  • Patent number: 7994354
    Abstract: Methods to convert biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: August 9, 2011
    Assignee: Battelle Memorial Institute
    Inventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
  • Publication number: 20110172421
    Abstract: An object of the present invention is to provide a novel photobase generator which can sensitively generate a base even by h-ray in place of a conventional 2-nitro-4,5-dimethoxybenzyloxycarbonylamine compound. Disclosed is an N-(?-aromatic group-substituted-2-nitro-4,5-dialkoxybenzyloxycarbonyl)amine compound represented by the following general formula (I). (In the above formula (I), R1 to R9 denote specific groups.
    Type: Application
    Filed: October 1, 2009
    Publication date: July 14, 2011
    Applicant: SHOWA DENKO K.K.
    Inventors: Isao Yamagami, Yoshihiko Maeda, Hiroshi Yasuda, Katsumi Murofushi
  • Publication number: 20110160478
    Abstract: The present invention pertains to a catalyst for the synthesis of organic alkyl carbamates, the method for preparing the same and the use thereof. The catalyst comprises a catalytically active component and a catalyst support, and the catalytically active component being carried by the catalyst support, wherein the catalytically active component comprises a transition metal oxide, and the general formula of the transition metal oxide is EOx, wherein E is selected from transition metal element and x is in the range of 0.5-4.
    Type: Application
    Filed: February 13, 2009
    Publication date: June 30, 2011
    Inventors: Youquan Deng, Yubo Ma, Liguo Wang, Xiaoguang Guo, Shigo Zhang, Yude He, Stefan Wershofen, Stephan Klein, Zhiping Zhou
  • Publication number: 20110136827
    Abstract: The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
    Type: Application
    Filed: December 7, 2010
    Publication date: June 9, 2011
    Inventors: John P. Toscano, Art Sutton, Vincent J. Kalish, Frederick Arthur Brookfield, Stephen Martin Courtney, Lisa Marie Frost
  • Publication number: 20110073977
    Abstract: There is provided an amino acid generator comprising a protecting group for an amino group that is eliminated to generate an amino acid, and a coating film forming composition using the amino acid generator and a polysiloxane composition containing the amino acid generator. A coating film forming composition comprising: a component (A): an amino acid generator comprising a protecting group that is eliminated to generate an amino acid, which is a compound of Formula (1): D-A (1) where D is a protecting group for an amino group, and A is an organic group remaining after subtracting hydrogen atoms from an amino group of an amino acid; a component (B): a hydrolyzable silane, a hydrolysis product thereof, a hydrolysis-condensation product thereof, or a mixture thereof; and a component (C): a solvent.
    Type: Application
    Filed: May 19, 2009
    Publication date: March 31, 2011
    Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Taku Kato, Junpei Kobayashi, Satoko Takano, Naoki Sakumoto
  • Publication number: 20110071093
    Abstract: Oligomeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble, non-peptidic oligomer and a pharmaceutically active agent. The oligomeric reagents are useful for, among other things, forming oligomer active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Application
    Filed: March 12, 2009
    Publication date: March 24, 2011
    Applicant: Nektar Therapeutics
    Inventor: Franco J. Duarte
  • Publication number: 20110065047
    Abstract: The present invention provides a photoresist composition comprising a resin, an acid generator and a compound represented by the formula (I): wherein R1, R2 and R3 each independently represent a hydrogen atom or a C1-C4 alkyl group, A1 represents a single bond or a C1-C2 alkylene group, R4 and R5 each independently represent a hydrogen atom or a C1-C2 alkyl group, R6 and R7 each independently represent a hydrogen atom etc.
    Type: Application
    Filed: September 13, 2010
    Publication date: March 17, 2011
    Applicant: SUMITOMO CHEMICHAL COMPANY, LIMITED
    Inventors: Tatsuro MASUYAMA, Mitsuhiro HATA
  • Patent number: 7897639
    Abstract: Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: wherein A is selected from the group consisting of an unsubstituted aryl, a substituted aryl, an unsubstituted heteroaryl and a substituted heteroaryl. The carbamoyl esters are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the carbamoyl esters can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: March 1, 2011
    Assignee: CoLucid Pharmaceuticals, Inc.
    Inventors: Jeroen C. Verheijen, ShouCheng Du
  • Publication number: 20110039209
    Abstract: The present invention provides a compound represented by the formula (C1): wherein Rc2 represents a C6-C10 aromatic hydrocarbon group having at least one nitro group and Rc1 represents a group represented by the formula (1): wherein Rc4 represents a hydrogen atom etc., Rc5 represents a C1-C30 divalent hydrocarbon group, and Rc3 represents a group represented by the formula (3-1), (3-2) or (3-3): wherein Rc6, Rc7, Rc8, Rc9, Rc10, Rc11, Rc12, Rc13 and Rc14 each independently represent a C1-C30 hydrocarbon group, and a photoresist composition comprising a resin, an acid generator and the compound represented by the formula (C1).
    Type: Application
    Filed: August 6, 2010
    Publication date: February 17, 2011
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Tatsuro Masuyama, Mitsuhiro Hata
  • Publication number: 20110015292
    Abstract: A prepolymer and products made from the preopolymer is described. The prepolymer includes the reaction product of at least one isocyanate and at least one natural oil based polyol. The natural oil based polyol includes at least two natural oil moieties separated by a molecular structure having an average of at least about 19 ether groups between any 2 of the natural oil moieties or by a polyether molecular structure having an equivalent weight of at least about 480.
    Type: Application
    Filed: March 20, 2009
    Publication date: January 20, 2011
    Applicant: DOW GLOBAL TECHNOLOGIES INC.
    Inventors: Bindushree Radhakrishnan, William A. Koonce, Laura A. Grier, Dwight D. Latham
  • Publication number: 20100303804
    Abstract: The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ?2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ?O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ?O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a)
    Type: Application
    Filed: November 21, 2008
    Publication date: December 2, 2010
    Applicant: TECHNISCHE UNIVERSITAT WIEN
    Inventors: Robert Liska, Jürgen Stampfl, Franz Varga, Heinrich Gruber, Stefan Baudis, Christian Heller, Monika Schuster, Helga Bergmeister, Günter Weigel, Claudia Dworak
  • Patent number: 7807738
    Abstract: A urea-urethane compound having one or more urea groups and one or more urethane groups in the molecular structure, the number of said urea groups (A) and the number of said urethane groups (B) satisfying the following numerical formula: 10?(A+B)?3 wherein each of A and B is an integer of 1 or more.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: October 5, 2010
    Assignee: Chemipro Kasei Kaisha, Ltd.
    Inventors: Kazuo Kabashima, Hiroshi Kobayashi, Tetsurou Iwaya
  • Patent number: 7786242
    Abstract: The ring-containing modified resin is represented by the following chemical formula (1) R1[—(—O—CO—NH—R2—NH—CO—O—R3—)p—O—R4]q??(1) (in the chemical formula (1), R1 is a dehydroxyl residue of a resin having a benzene ring and/or a condensed ring and hydroxyl group: —R2— is deisocyanate group derived from an organic diisocyanate: —R3— is a dehydroxyl residue of polyol having number-average molecular weight of 200 to 30000: p is 1 to 3: —R4 is a hydrogen atom, alkyl group having 1 to 18 carbons, phenyl group: q is the same number as the number of the dehydroxyl residue of R1).
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: August 31, 2010
    Assignee: Kyoeisha Chemical Co., Ltd.
    Inventor: Motoe Hosoda
  • Publication number: 20100191010
    Abstract: Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO2 in the presence of ionic liquids and optionally in the presence of a base.
    Type: Application
    Filed: June 11, 2008
    Publication date: July 29, 2010
    Applicant: Huntsman International LLC
    Inventors: Joris Karel Peter Bosman, Robert Henry Carr
  • Publication number: 20100144869
    Abstract: A novel use of conjugates of psychotropic drugs (e.g., antidepressants or anti-epileptic drugs) and organic acids such as GABA in the treatment of pain is disclosed. A novel GABA conjugate and uses thereof is also disclosed.
    Type: Application
    Filed: July 17, 2007
    Publication date: June 10, 2010
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
  • Publication number: 20100113819
    Abstract: The present invention provides methods of forming carbamates, ureas, and isocyanates. In certain embodiments these methods include the step of reacting an amine with an ester-substituted diaryl carbonate to form an activated carbamate which can be further derivitized to form non-activated carbamate or a urea. The urea or carbamate can be subjected to a pyrolysis reaction to form isocyanate.
    Type: Application
    Filed: December 31, 2008
    Publication date: May 6, 2010
    Applicant: SABIC INNOVATIVE PLASTICS IP BV
    Inventors: Hatem Abdallah Belfadhel, Hans-Peter Brack, Ricardo Godoy-Lopez, Dennis James Patrick Maria Willemse
  • Publication number: 20100093981
    Abstract: The present invention relates to carbamoylation of amines, mercaptanes, thiophenols and phenols employing organic azides. More specifically, the invention relates to a method for generating urea derivatives, thiocarbamate derivatives and carbamate derivatives, and is based on the intermediate formation of isocyanate, starting from an organic azide. The reaction as described is useful in applications for modified nucleoside synthesis, oligonucleotide synthesis, as well as modification, labeling and conjugation of polymers and biomolecules.
    Type: Application
    Filed: October 25, 2007
    Publication date: April 15, 2010
    Inventors: Andrey Yagodkin, Alex Azhayen
  • Patent number: 7696374
    Abstract: The invention relates to a compound having general formula (I): Wherein n, A, R1, R2, and R3 are as defined herein. The invention also relates to methods of preparation of compound of formula (I) as well as its use in therapeutics.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: April 13, 2010
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia
  • Publication number: 20100080880
    Abstract: The present invention concerns geranylamine derivates of oxalic acid, use of the same as flavorings and certain mixtures, compositions, preparations and semi-finished goods containing one or more such compounds.
    Type: Application
    Filed: September 23, 2009
    Publication date: April 1, 2010
    Applicant: SYMRISE GmbH & Co. KG
    Inventors: Michael Backes, Jan Looft
  • Publication number: 20100074880
    Abstract: The present invention includes a novel polyethylene glycol derivative; a drug carrier comprising the derivative; and a pharmaceutical composition comprising the drug carrier having a pharmacologically active substance included therein. Specifically disclosed are: a polyethylene glycol derivative represented by the general formula (I); a drug carrier comprising the derivative and 2-O-(2-diethylaminoethyl)carbamoyl-1,3-O-dioleoyl-glycerol; and a pharmaceutical composition comprising the drug carrier and a pharmacologically active substance (preferably double-stranded RNA, double-stranded DNA or an oligonucleic acid), wherein R represents a saturated or unsaturated aliphatic hydrocarbon group having 10 to 30 carbon atoms or a saturated or unsaturated fatty acid residue having 10 to 30 carbon atoms; and n represents an integer of 30 to 150.
    Type: Application
    Filed: February 4, 2008
    Publication date: March 25, 2010
    Applicant: NIPPON SHINYAKU CO., LTD.
    Inventors: Satoru Sonoke, Toshihiro Ueda
  • Patent number: 7674805
    Abstract: The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: March 9, 2010
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia, Jacques Froissant, Christian Hoornaert
  • Publication number: 20100022719
    Abstract: A compound, oligomer, or polymer having a functional group of formula (I) wherein R is a group having 1 to 12 carbons and optionally including one or more heteroatoms selected from oxygen, nitrogen, and sulfur is useful in curable compositions having active hydrogen functional groups reactive with group (I). The functional groups of formula (I) and active hydrogen functional groups may be part of the same material or different materials. In some embodiments a filler is surface modified to have a functional group of formula (I). Also disclosed is a method of making a material having a functional group of formula (I).
    Type: Application
    Filed: December 29, 2008
    Publication date: January 28, 2010
    Applicant: BASF CORPORATION
    Inventor: Walter H. Ohrbom
  • Patent number: 7635784
    Abstract: The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: December 22, 2009
    Assignees: Hoffmann-La Roche Inc., Roche Palo Alto LLC
    Inventors: Thomas Cleary, Yaohui Ji, Gary R. Lee, Thimma Rawalpally, Keshab Sarma
  • Patent number: 7635662
    Abstract: A urea-urethane compound having one or more urea groups and one or more urethane groups in the molecular structure, the number of said urea groups (A) and the number of said urethane groups (B) satisfying the following numerical formula: 10?(A+B)?3 wherein each of A and B is an integer of 1 or more.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: December 22, 2009
    Assignee: Chemipro Kasei Kaisha, Ltd.
    Inventors: Kazuo Kabashima, Hiroshi Kobayashi, Tetsurou Iwaya
  • Patent number: 7635742
    Abstract: Modified stable polyisocyanates are described having at least one isocyanate function modified by a group having cross-linking functionality.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: December 22, 2009
    Assignee: Rhodia Chimie
    Inventor: Jean-Marie Bernard
  • Patent number: 7625988
    Abstract: The present invention is directed to novel flame retardant monomers and polymers, wherein the flame retardant properties of the polymers are provided by functionality in pendant groups attached to a polymer backbone (as opposed to the polymer backbone itself possessing flame retardant properties. The present invention is also directed to methods of making such polymers and monomers, and articles of manufacture incorporating such monomers and polymers.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: December 1, 2009
    Assignee: William Marsh Rice University
    Inventors: James M. Tour, Joshua L. Jurs, Jason J. Stephenson
  • Publication number: 20090270499
    Abstract: This invention relates to a process for synthesizing Atazanvir, including novel intermediates and novel steps to various intermediates along the synthetic pathway.
    Type: Application
    Filed: April 24, 2008
    Publication date: October 29, 2009
    Applicant: OXYRANE (UK) LIMITED
    Inventor: Weiping Chen
  • Patent number: 7598421
    Abstract: The invention provides a lipid of general formula (I) or (II): wherein X1, X2 and R1 to R5 are as defined herein. Such lipids are used to form complexes with a biologically-active material such as a nucleic acid, peptide or small molecule for delivering the biologically-active material to cells. The complexes may incorporate an integrin-binding peptide and, when the biologically-active material is DNA, thereby constitute a LID complex.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: October 6, 2009
    Assignee: UCL Biomedica PLC
    Inventors: Helen C. Hailes, Alethea B. Tabor, John B. Wong, Michael Pilkington-Miksa, Stephen L. Hart, Christopher A. Hurley
  • Publication number: 20090247718
    Abstract: The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acrylate having a urethane bond represented by the formula (1), and cyclic ketal (meth)acrylate having a urethane bond represented by the formula (2): (R1: H, —CH3; R2: —(CH2)n-; R3: —(CH2)m-; n: 1-4; m: 1-8; (AO): C2-C4 oxyalkylene group; x: 0-1000; R4, R5: H, —CH3, —C2H5).
    Type: Application
    Filed: June 4, 2009
    Publication date: October 1, 2009
    Applicant: NOF Corporation
    Inventors: Eui-chul KANG, Atsuhiko OGURA, Shingo KATAOKA, Takashi IWATA
  • Patent number: 7589229
    Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2?CHCO2— TBu by nucleophilic addition to form the triester nitrotrialkanoate of the formula and then reducing the nitrosubstituent to afford the said amine monomer.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: September 15, 2009
    Assignee: The University of South Florida
    Inventors: George R. Newkome, Charles N. Moorefield, Rajani K. Behera
  • Patent number: RE41226
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine polymitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: April 13, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini