Unsaturation In Acid Moiety Patents (Class 560/183)
  • Publication number: 20100273909
    Abstract: Disclosed is a urethane (meth)acrylate oligomer which is obtained by reacting at least one polyoxyalkylene polyol (A), at least one monool (B1) soluble in the component (A) and/or at least one silane coupling agent (B2) reactive with an isocyanate group, at least one polyisocyanate (C) and at least one hydroxylated mono(meth)acrylate compound (D) at a ratio at which the equivalent weights of hydroxy groups, active hydrogen groups and isocyanate groups in the respective components satisfy the following formulae (1)-(3). The urethane (meth)acrylate oligomer does not substantially contain an unreacted isocyanate group. B(active hydrogen)+D(OH)=C(NCO)?A(OH) (1) 1.05?C(NCO)/A(OH)?2 (2) {C(NCO)?2A(OH)+2 m}×0.35?D(OH)?{C(NCO)?2A(OH)+2 m}×0.
    Type: Application
    Filed: August 3, 2007
    Publication date: October 28, 2010
    Inventors: Yoshinobu Ogawa, Kazutoshi Doki, Osamu Kawata, Yoshihiro Tani
  • Publication number: 20100217031
    Abstract: The present invention relates to a continuous process for preparing alkyl 3,3-dialkoxy-propionates of the formula (RO)2CHCH2CO2R, wherein R is C1-6 alkyl, by reacting ketene with an ortho formate of formula (RO)3CH in the presence of an acidic catalyst, characterized in that the reaction is carried out in a loop reactor.
    Type: Application
    Filed: October 29, 2008
    Publication date: August 26, 2010
    Inventors: Wolfgang Wenger, Cornelia Zur Täschler, Daniel Zollinger
  • Publication number: 20100217030
    Abstract: The present invention relates to a process for purifying unsaturated compounds, said purification being performed in a plant which comprises at least two evaporators which are connected in such a way that a portion of the unsaturated compound is circulated, the vapours condensed in the first evaporator being isolated and the vapours condensed in the second evaporator being introduced into the first evaporator, which is characterized in that the mass flow with which the condensed vapours are isolated from the mixture to be purified in the first evaporator is less than the mass flow with which the condensed vapours from the second evaporator are introduced into the first evaporator.
    Type: Application
    Filed: August 29, 2008
    Publication date: August 26, 2010
    Applicant: EVONIK ROEHM GMBH
    Inventors: Benedikt Laux, Christian Maul, Volker Schleep, Ingo Sander
  • Patent number: 7750108
    Abstract: Copolyesters containing secondary hydroxyl groups are useful polyols for manufacturing polyurethanes. These can be prepared by reacting a secondary hydroxyl-containing fatty acid or ester thereof with an initiator containing hydroxyl and/or primary or secondary amino groups. A copolyester of particular interest includes a poly(ethylene oxide) segment derived from a poly(ethylene oxide) initiator.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: July 6, 2010
    Assignee: Dow Global Technologies Inc.
    Inventors: Zenon Lysenko, David A. Babb, Kenneth J. Stutts, Robbyn Prange, Min Zhang, Alan K. Schrock
  • Patent number: 7682522
    Abstract: The invention includes compounds represented by Formula (1): wherein R represents hydrogen or methyl; A represents alkylene having from 1 to 12 carbon atoms, wherein in the alkylene, arbitrary —CH2— may be replaced by —O—, —S—, —CH?CH—, —CO—, —COO— or —OCO—; X and Y each independently represent an aromatic ring or a cyclohexane ring, wherein in the rings, arbitrary hydrogen may be replaced by alkyl having from 1 to 3 carbon atoms; Z independently represents a single bond, —O—, —S—, —COO—, —OCO—, —CON(R1)— or —N(R1)CO—, wherein R1 represents hydrogen or methyl; and m represents an integer of from 0 to 3.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: March 23, 2010
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventor: Mayumi Tanabe
  • Publication number: 20090156673
    Abstract: (Neuro)protectin D1 (1OR,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) and 15,16-dehydro-PD1 and their derivatives are useful in the treatment of airway inflammation, especially asthma.
    Type: Application
    Filed: October 3, 2006
    Publication date: June 18, 2009
    Applicant: The Brigham and Women's Hospital, Inc. Corporate Sponsored Research & Licensing
    Inventors: Charles N. Serhan, Nicos A. Petasis, Bruce D. Levy
  • Publication number: 20090128767
    Abstract: It is an object of the present invention to provide a curable resin composition for a column spacer which has excellent developability and solubility and is capable of forming a clearly patterned column spacer without leaving a development residue at the time of pattern formation of the column spacer to be used in producing a liquid crystal display panel. The present invention is directed to a curable resin composition for a column spacer, which contains a compound having two or more polymerizable unsaturated bonds in a molecule, an alkali-soluble polymer compound, and a photo-reaction initiator, the compound having two or more polymerizable unsaturated bonds in a molecule being an oxide-modified compound having two or more polymerizable unsaturated bonds in a molecule.
    Type: Application
    Filed: May 30, 2006
    Publication date: May 21, 2009
    Inventors: Minoru Suezaki, Yoshio Nishimura, Toru Takahashi, Sayaka Kobayashi, Tatsuya Matsukubo
  • Patent number: 7517911
    Abstract: The present invention relates to ester compounds derived from 3,4,5-trimethoxy phenyl acetate, 3,4,5-trimethoxy cinnamate or 3,4,5-trimethoxy hydrocinnamate that are represented by Formula (I), wherein R1 is CH2—, —CH?CH— or CH2—CH2, R2 is thymyl or carvacryl, to methods for preparing them, and to a whitening cosmetic composition containing the ester compounds. Because the ester compounds of the present invention inhibit the generation of melanin, the cosmetic composition can improve the skin pigmentation and can be used for whitening cosmetics.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: April 14, 2009
    Assignee: Amorepacific Corporation
    Inventors: Ho-Sik Rho, Jae-Sung Hwang, Hyun-Jung Choi, Hyun-Jung Shin, Bae-Hwan Kim, Eun-Young Lee, Byeong-Gon Lee, Duck-Hee Kim
  • Patent number: 7488824
    Abstract: The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim 1, by reaction of a compound of formula (II) wherein R3 is C1-C8alkyl or C3-C6cycloalkyl and R4 and R05 are as defined for formula (I), with a compound of formula (III) wherein R, R1, R2 and X1, are as defined for formula (I) in claim 1, in an inert solvent in the presence of a proton source.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: February 10, 2009
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: David Anthony Jackson, Martin Charles Bowden
  • Publication number: 20090012320
    Abstract: Carbonyl compounds of the formula (II), wherein R1 and R2 are as defined herein, react in the presence of an amine with carboxylic acid derivatives of the formula (II), wherein R3 and EWG are also as defined herein, to give ?,?-unsaturated compounds of the formula (I) according to the following scheme: It is possible under mild reaction conditions to obtain unsaturated esters with high (E) stereoselectivity. The reaction typically proceeds at room temperature or lower without particular requirements such as inert gas, exclusion of moisture, heat, etc., being made. The only by-products obtained are CO2 and water.
    Type: Application
    Filed: May 9, 2006
    Publication date: January 8, 2009
    Applicant: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Benjamin List, Maria Hechavarria-Fonseca, Arno Dohring, Andreas Job
  • Patent number: 7449513
    Abstract: A polymer compound is provided which is suitable to improve the dispersibility of coloring materials or solids in an ink or toner composition and which has a repeating unit represented by the general formula (2): (2) wherein X? represents a polyalkenyl group; each A represents independently a linear or branched alkylene group of 1 to 15 carbon atoms which may be substituted; m represents an integer of 0 to 30; B represents a single bond or an alkylene group which may be substituted; each D represents independently an aromatic ring in which at least one hydrogen atom attached to the ring is displaced by a fluorine atom; n represents an integer of 1 to 10; and R represents a hydrogen atom, an alkyl group which may be substituted, or an aromatic ring which may be substituted.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: November 11, 2008
    Assignee: Canon Kabushiki Kaisha
    Inventors: Koichi Sato, Ikuo Nakazawa, Sakae Suda, Masayuki Ikegami, Keiichiro Tsubaki, Ryuji Higashi, Keiko Yamagishi
  • Patent number: 7423170
    Abstract: Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g. a farnesyl group) is attached to the protein in the presence of an enzyme (e.g. farnesyl protein transferase). Deactivation of the prenylation enzyme through covalent modification can therefore ultimately result in the mitigation and/or cessation of cancer cell growth. Various prenylation inhibitors having the necessary structural groups to bond covalently, or essentially irreversibly, to the prenylation enzyme include carbonyl or thiocarbonyl compounds (or masked versions of these compounds) and alpha oxo-epoxides bonded to a hydrophobic, substrate-mimicking group. The carbonyl or thiocarbonyl compounds also contain a nucleofugal atom or group to enhance the tendency to form covalent bonds.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: September 9, 2008
    Assignee: Arizona Biomedical Research Commission
    Inventors: Seth D. Rose, Scott R. Lefler, Steven R. Ottersberg, Ann Y. Kim, Karl J. Okolotowicz, Rosemarie F. Hartman
  • Patent number: 7407707
    Abstract: The invention detailed herein comprises a family of radiation-curable coating formulations specifically for metal substrates. These coating formulations are based on multifunctional acrylate resins formed by the reaction of acrylate monomers and oligomers with ÿ-keto esters (e.g., acetoacetates), ÿ-diketones (e.g., 2, 4-pentanedione), ÿ-keto amides (e.g., acetoacetanilide, acetoacetamide), and/or other ÿ-dicarbonyl compounds that can participate in the Michael addition reaction. An essential novelty of these coating resins is that they will cure under standard UV-cure conditions without the addition of traditional photoinitiators. Other materials, both reactive (conventional acrylates) and non-reactive (e.g., solvents) may also be incorporated into the resin oligomers to enhance the coatings properties on metal substrates.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: August 5, 2008
    Assignee: Ashland Licensing and Intellectual Property LLC
    Inventors: Michael Gould, Thomas L. Marino, Alexandre Mejiritski, Dustin B. Martin
  • Patent number: 7393961
    Abstract: (Per)haloethers having formula: X-(Rf)L-O—CF2CF2—O—CX1X2—CFX3X4 , ??(I) process for obtaining them and hypofluorites usable in the synthesis of said (per)haloethers.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: July 1, 2008
    Assignee: Solvay Solexis S.p.A.
    Inventors: Giovanni Fontana, Walter Navarrini
  • Patent number: 7378558
    Abstract: A process for preparing carotenoids, in which the process includes reacting a dialkoxy dialdehyde in a double Wittig condensation with a phosphonium salt of or in a double Wittig-Horner condensation with a phosphonate. The carotenoids include, for example, ?-carotene, zeaxanthin, canthaxanthin, astaxathin, lycopene and croceptin, which are useful as nutraceuticals, food colorants, and feed additives.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: May 27, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Hansgeorg Ernst, Klaus Henrich, Andreas Keller
  • Patent number: 7261836
    Abstract: The invention pertains to a phenylethanediol derivative having at least one polymerizable group, characterized in that the phenylethanediol derivative further comprises at least one photo-convertible group for adjusting the helical twisting power of the phenylethanediol derivative. According to a preferred embodiment the phenylethanediol has the formula wherein A stands for a bond or a p-phenylene group; B and B? are independently (O)p—CoH2o—O—CO—CR??CH2, o being 2-12, p being 0 or 1, and R? being H or CH3; P stands for a CH2 or a C?O group; Q and Q? are independently selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN; n is an integer from 1 to 3; and m is an integer from 0 to 2; and: wherein A stands for a bond or a p-phenylene group; B is (O)p—CoH2o—O—CO—CR??CH2, o being 2-12, p is 1, and R? being H or CH3; P stands for a CH2 or a C?O group; Q is selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN; and m is an integer from 0 to 2.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: August 28, 2007
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Johan Lub, Rene Theodorus Wegh
  • Patent number: 7232875
    Abstract: A comb-branched polymer is disclosed. The polymer comprises recurring units of an unsaturated carboxylic monomer, an oxypropylene-rich poly(oxyethylene-oxypropylene) macromonomer and an oxyethylene-rich poly(oxyethylene-oxypropylene) macromonomer. The comb-branched polymer can be used as a water reducing agent in cement. It gives significantly lower air entrainment in cement admixture.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: June 19, 2007
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Frank J. Liotta, Jr., Edward T. Shawl
  • Patent number: 7214817
    Abstract: The present invention provides: a high-quality hydroxyalkyl (meth)acrylate of which the alkylene glycol di(meth)acrylate content and the acid component content are both low; and its novel production process. The hydroxyalkyl (meth)acrylate, which has a content, in terms of an alkylene glycol di(meth)acrylate as an impurity, of not more than 0.1 weight % and an acid component content of not more than 0.1 weight %, is obtained by a process comprising the step of carrying out a batch reaction between (meth)acrylic acid and an alkylene oxide in the presence of a catalyst in order to produce the hydroxyalkyl (meth)acrylate; with the process making an adjustment as to charging of both raw materials in such a manner that, for, of a time as needed for supplying both raw materials, a supplying time of not less than 40% of a total supplying time when the raw materials as supplied have a temperature of not lower than 40° C.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: May 8, 2007
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Tokumasa Ishida, Hiroyuki Takaki, Masahiro Uemura
  • Patent number: 7186856
    Abstract: Processes for preparing carboxylic acids and derivatives thereof in which an ammonium salt of the carboxylic acid is heated in the presence of an organic reagent to split the salt and form the acid or, where the organic reagent is an esterifying agent, the corresponding ester. Both the acid and the ester may be dehydrated to form unsaturated counterparts.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: March 6, 2007
    Assignee: Cargill, Incorporated
    Inventors: Xiangsheng Meng, Paraskevas Tsobanakis, Jeffrey Malsam, Timothy W. Abraham
  • Patent number: 7109371
    Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: September 19, 2006
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Derek Wyndham Clissold, Stuart Wilbert Craig, Rajendrakumar Reddy Gadikota, Min He, Jurjus Fayez Jurayj, Shahrokh Kazerani, Erwin Rannala, Pradeep Kumar Sharma
  • Patent number: 6956018
    Abstract: A polymerizable polyoxyalkylene monoalkyl ether derivative prepared by using a polyoxyalklene monoalkyl ether which gives, in gel permeation chromatography, a chromatogram which satisfies a relation expressed by an equation: S1/S0?0.
    Type: Grant
    Filed: July 13, 2004
    Date of Patent: October 18, 2005
    Assignee: Nof Corporation
    Inventors: Akinori Itoh, Susumu Honda, Tatsuya Matsui, Yoshihiro Hayashi
  • Patent number: 6953850
    Abstract: The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the specific deprotection of any substituent ono the saccharide ring, and greatly facilitates targeted or library-focused carbohydrate-related syntheses. In particular, the invention provides a universal monosaccharide building block of General Formula (I) or General Formula (II) in which A is a leaving group; X is hydrogen, O, N or N3; X1 is hydrogen, —CH2O—, —CH2NH—, —CH3, —CH2N3 or —COO—; and B, C, D and E are protecting groups that can be cleaved orthogonally, and in which B, C, D and E are absent when X is hydrogen or N3, and E is absent when X1 is hydrogen, CH3 or N3.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: October 11, 2005
    Assignee: Alchemia Pty. Ltd.
    Inventors: Gyula Dekany, John Papagerogiou, Laurent Francois Bornaghi
  • Patent number: 6916890
    Abstract: The present invention discloses reworkable epoxy compositions suitable for encapsulation of and underfill for electronic components including (a) the epoxidized reaction product of a multifunctional 1-alkenyl ether or 1-cycloalkenyl ether and an alkenyl carboxylic acid, the epoxidized reaction product having two or more thermally labile alpha-alkoxy ester linkages; and (b) a curing agent for the epoxy component. The epoxy composition, when cured, provides a composition which is thermally reworkable, the weak ?-alkoxy ester linkages providing for the reworkable aspect of the invention.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: July 12, 2005
    Assignee: Henkel Corporation
    Inventors: John G. Woods, Susanne D. Morrill
  • Patent number: 6878845
    Abstract: Oligomers from multifunctional acrylates and organonitro compounds are provided. Films obtained from crosslinked oligomers of the present invention are useful as protective or decorative coatings as well as components in adhesives and composites.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: April 12, 2005
    Assignee: Ashland Inc.
    Inventors: Matthew S. Sheridan, Laurence G. Dammann, Sridevi Narayan-Sarathy
  • Publication number: 20040171867
    Abstract: The present invention Nos.
    Type: Application
    Filed: March 1, 2004
    Publication date: September 2, 2004
    Inventor: Akira Okazaki
  • Patent number: 6743943
    Abstract: Vinyl ether compounds having the formula: R—O—X—O—CH═CH2 wherein R is a radical selected from R1—CnHm—, R1—CnHm—C(═O)—, R1—CnHm—CH[—O—X—O—CH═CH2—], R1—CnHm—CH[—O—X—O—CH═CH2—]C(═O)—, R1—CnHm—CH[—C(═O)—O—X—O—CH═CH2—], R1—CnHm—CH[—C(═O)—O—X—O—CH═CH2—]C(═O)—, R1—[CFCl—CF2—]pCH2— and HCFCl—CF2—, wherein R1 is hydrogen, an unsubstituted or substituted fluorinated aliphatic radical, an unsubstituted or substituted fluorinated cyclic aliphatic radical, an unsubstituted or substituted fluorinated aromatic radical, an unsubstituted or substituted fluorinated araliphatic radical, or an unsubstituted or substituted fluorinated heterocyclic rad
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: June 1, 2004
    Assignee: Honeywell International Inc.
    Inventors: Russell F. Anderson, David E. Bradley, David Nalewajek, Haridasan K. Nair, Mariola J. Proszowski, Eugene V. Sitzman, Ellen L. Swan
  • Patent number: 6723843
    Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: April 20, 2004
    Assignee: Alchemia PTY LTD
    Inventors: Istvan Toth, Gyula Dekany, Barry Kellam
  • Patent number: 6720445
    Abstract: Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions using these compounds are also disclosed. The compounds are effective in the inhibition of histone deacetylase.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: April 13, 2004
    Assignee: Beacon Laboratories, Inc.
    Inventors: Hsuan-Yin Lan-Hargest, Norbert L. Wiech
  • Patent number: 6692728
    Abstract: The present invention provides biodegradable polyesters based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for sunscreens, skin lotions and by themselves are also useful as milder skin exfoliants.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: February 17, 2004
    Assignee: Ethox Chemicals LLC
    Inventors: Paul David Weipert, Bharat B. Desai
  • Patent number: 6639095
    Abstract: The present invention provides a process for preparing optically active &agr;-hydroxy acids and derivatives thereof by subjecting the alkylated 1,3-dioxolanones of formula (IV) wherein R1 and R2 are the same or different and are each independently H or C1-6 alkyl; R5 is H, C1-16 alkyl, or unsubstituted or substituted phenyl; and R6 is C1-8 alkyl, C2-7 alkenyl or unsubstituted or substituted benzyl, to either alcoholysis or hydrolysis, in which the alkylated 1,3-dioxolanones are obtained by using 10-camphorsulfonamide as a chiral auxiliary.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: October 28, 2003
    Inventors: Biing-Jiun Uang, Jia-Wen Chang, Der-Pin Jang
  • Patent number: 6610892
    Abstract: The invention relates to a process for preparing 2,7-dimethyl-2,4,6-octatrienal monoacetals of the general formula I which comprises a) condensing an ester phosphonium salt of the general formula II or an ester phosphonate of the general formula III with an aldehyde of the formula IV in a Wittig or Wittig-Horner reaction to give an acetal ester of the general formula V b) reducing the ester of the formula V to give an acetal alcohol of the general formula VI and c) oxidizing the alcohol to 2,7-dimethyl-2,4,6-octatrienal monoacetals of the general formula I, where the substituents have the meaning defined in the description.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: August 26, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Hansgeorg Ernst, Klaus Henrich
  • Patent number: 6573391
    Abstract: The present invention relates to novel macrocyclic compounds, and to their preparation and use in perfumes. Specifically, the present invention relates to novel 1,4-dioxacycloalkan-2ones and 1,4-dioxzcycloaken-2-ones.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: June 3, 2003
    Assignee: Haarmann & Reimer GmbH
    Inventors: Marcus Eh, Peter Wörner
  • Patent number: 6573337
    Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: June 3, 2003
    Assignee: Alchemia Pty LTD
    Inventors: Istvan Toth, Gyula Dekany, Barry Kellam
  • Publication number: 20030100791
    Abstract: Acrylic esters containing fluorine at &agr;-position and having an alkoxymethyl group introduced into the ester side chain thereof are novel. Polymers obtained from the acrylic esters are improved in transparency, acid elimination and substrate adhesion and are used to formulate chemically amplified resist compositions for lithographic microfabrication.
    Type: Application
    Filed: November 27, 2002
    Publication date: May 29, 2003
    Inventors: Yuji Harada, Jun Hatakeyama, Yoshio Kawai, Masaru Sasago, Masayuki Endo, Shinji Kishimura, Kazuhiko Maeda, Michitaka Ootani, Haruhiko Komoriya
  • Patent number: 6540987
    Abstract: The present invention provides biodegradable polyesters based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for sunscreens, skin lotions and by themselves are also useful as milder skin exfoliants.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: April 1, 2003
    Assignee: Ethox Chemicals LLC
    Inventors: Paul David Weipert, Bharat B. Desai
  • Publication number: 20030004368
    Abstract: An enantiomerically enriched compound of formula 1, 1
    Type: Application
    Filed: August 19, 2002
    Publication date: January 2, 2003
    Inventors: Philip Mark Jackson, Ian Campbell Lennon
  • Patent number: 6495594
    Abstract: The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents. The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: December 17, 2002
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Sarath P. Gunasekera, Ross E. Longley, Richard A. Isbrucker, Gopal K. Paul, Shirley A. Pomponi, Amy E. Wright
  • Patent number: 6495220
    Abstract: Compounds of the formula (I) R1—A—Z1  (I) in which: R1 is an alkyl radical having 1 to 8 carbon atoms or an alkenyl radical having 2 to 8 carbon atoms, where, in each case, one (nonterminal) —CH2— group may also be replaced by —O— or —C(═O)O— and/or one or more H may be replaced by F A is phenanthrene-2,7-diyl or 9,10-dihydrophenanthrene-2,7-diyl Z1 is F, OCHxF3−x or CHxF3−x, where, in each case, x is 0, 1 or 2, OC2HzF5−z or C2HzF5−z, where, in each case, z is 0, 1, 2, 3 or 4, CH═CF2 or Cl, with the proviso that 2-fluoro-7-methoxy-phenanthrene is excluded.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: December 17, 2002
    Assignee: Clariant International Ltd.
    Inventors: Hans-Rolf Dübal, Barbara Hornung, Wolfgang Schmidt, Rainer Wingen
  • Publication number: 20020161267
    Abstract: A polyoxyalkylene monoalkyl ether which gives, in gel permeation chromatography, a chromatogram which satisfies a relation expressed by an equation: S1/S0≦0.
    Type: Application
    Filed: June 15, 1999
    Publication date: October 31, 2002
    Applicant: NOF CORPORATION, Tokyo, Japan
    Inventors: AKINORI ITOH, SUSUMU HONDA, TATSUYA MATSUI, YOSHIHIRO HAYASHI
  • Patent number: 6452038
    Abstract: The present invention provides a compound according to the formula: CH2═C(R1)—C(O)—R6—NHCO2(CH2)p(CF2)q—O—((CF2)aCFXO)m(CF2)r—Z wherein each R1 is independently selected from —H, —CH3, —F and —Cl, wherein each R6 is independently selected from substituted or unsubstituted C1-C10 alkyl, cyclic alkyl, or aryl groups, wherein each a is independently selected from 0-3, wherein each X is independently selected from —F, —CF3 or —CF2CF3, wherein each p is independently selected from 1-4, each q is independently selected from 1-5, each r is independently selected from 1-5, each m is independently selected from 1-50, each Z is independently selected from —F and —(CH2)sOH, and each s is independently selected from 1-4. The present invention also provides for the use of this compound as a surfactant in highly fluorinated liquid solvents. Latexes of dispersed particles utilizing this surfactant are provided.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: September 17, 2002
    Assignee: 3M Innovative Properties Company
    Inventors: Prabhakara Satyauolu Rao, Naiyong Jing
  • Patent number: 6452042
    Abstract: Substituted propenoates are prepared by eliminating an alcohol from a substituted malondialdehyde acetal, optionally in the presence of a homogeneous or heterogeneous catalyst.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: September 17, 2002
    Assignee: Creanova, Inc.
    Inventors: Frank Bauer, Chitoor Subramaniam
  • Patent number: 6436994
    Abstract: Heteroatom-interrupted HETE derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: August 20, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Raymond E. Conrow, Peter G. Klimko
  • Patent number: 6413698
    Abstract: A photohardenable resin composition comprising (A) a urethanated acrylic compound represented by formula (I): (A)a—C—(R)4−a wherein R is H or alkyl; a is 3 or 4; and A represents a group of formula (II): wherein D represents —CH2CH2O—, —CH2CH(CH3)O—, —CH2CH2COO— or —(CH2)6COO—; E represents —CH2CH2O—, —CH2CH(CH3)O—, —COCH2CH2O— or —CO(CH2)6O—; G represents a diol or triol residual group; J represents a divalent or trivalent and substituted or unsubstituted hydrocarbon group; L represents —(CH2CH2O)h— (h: integer of 1 to 4), —(CH2CH(CH3)O)j— (j: integer of 1 to 4), or —(CH2CH2O)k—(CH2CH(CH3)O)m— (k, m: integer of 1 to 3 (k+m=2, 3 or 4); b, c, and d are each 0 or 1 (b+c+d=1, 2 or 3); e is 0, 1 or 2; f is 0 or 1 (e+f=1 or 2); and g is 1 or 2, and (B) a radical polymerizable compound at a (A) : (B) r
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: July 2, 2002
    Assignees: Teijin Seiki Co., Ltd., Takemoto Yushi Kabushiki Kaisha, Shin-Nakamura Chemical Co., Ltd.
    Inventors: Yorikazu Tamura, Tsuneo Hagiwara, Makoto Ohtake, Minoru Shinoda, Toshiharu Suzuki, Tatsuhiko Ozaki, Yasushi Ishihama, Takayuki Nakamura
  • Publication number: 20020049350
    Abstract: A single batch process for preparing (R)-benzyl-4-hydroxy-2-pentynoate by reacting (R)-3-butyn-2-ol with 1,1,1,3,3,3-hexamethyldisilazane to silylate the starting alcohol, followed by deprotonation with an alkyl lithium compound, then a reaction with a haloformate compound, and finally a hydrolysis reaction to arrive at the product ester.
    Type: Application
    Filed: June 26, 2001
    Publication date: April 25, 2002
    Inventors: Xiaoyong Fu, Chou-Hong Tann, T.K. Thiruvengadam, Jianguo Yin, Timothy L. McAllister, Cesar Colon
  • Patent number: 6372923
    Abstract: The present invention provides a process for preparing an alcohol derivative, where the alcohol derivative is an ester, acetal, ketal, ether glycoside, or alkyl glycoside, by reacting an alcohol with a carbonyl compound, alcohol, olefin, epoxy compound or saccharide, where C2-4 vicinal alkylene oxides are excluded, in the presence of (A) an aluminum alkoxide and (B) sulfuric acid or phosphoric acid.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: April 16, 2002
    Assignee: Kao Corporation
    Inventors: Mitsuru Uno, Munehisa Okutsu, Tomohito Kitsuki
  • Patent number: 6358675
    Abstract: The polymers of the invention are characterized by having at least one pendent ester group having a tertiary carbon atom attached to the ester oxygen atom in which at least one substituent of the tertiary carbon atom comprises at least one silicon atom. The polymer compositions of the present invention are useful as resist materials for lithography, in particular as the imaging layer or as the top imaging layer in a bilayer resist scheme for use in the manufacture of integrated circuits. The silicon-containing tertiary alcohols and esters of the present invention enable the preparation of polymers with relatively high silicon content.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: March 19, 2002
    Assignee: 3M Innovative Properties Company
    Inventors: Larry D. Boardman, Carl R. Kessel
  • Patent number: 6337420
    Abstract: An electroclinic device having two spaced cell walls each bearing electrode structures and treated on at least one facing surface with an alignment layer, a layer of a smectic liquid crystal material enclosed between the cell walls, where the liquid crystal material contains one or more of the compounds described by formula I as defined in the specification.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: January 8, 2002
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland Defence Evaluation Research Agency
    Inventors: Andrew John Slaney, Damien Gerard McDonnell, Amarjit Kaur Samra, Maurice Stanley, Victoria Minter, John William Goodby, Michael Hird, Simon John Cross, Chu Chuan Dong
  • Patent number: 6307044
    Abstract: The present invention is directed to a process for the preparation of a compound of formula (X-a): or a pharmaceutically acceptable salt form thereof, wherein: R1 is selected from the group consisting of: C1-5 alkyl substituted with 0-5 R1a, —(CH2)r—C3-10 cycloalkyl substituted with 0-5 R1a, and —(CH2)r-aryl substituted with 0-5 R1a. Compounds of Formula (X-a) are macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-succinates are formed by an Ireland Claisen rearrangement of a silyl ketene acetal which proceeds with high stereoselectivity.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: October 23, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Roberta L. Dorow, Silvio Campagna, Pasquale N. Confalone, Fuqiang Jin, Zhe Wang
  • Patent number: 6255343
    Abstract: 2,2-Difluoro HETE derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: July 3, 2001
    Assignee: Alcon Universal Ltd.
    Inventor: David B. Belanger
  • Patent number: 6242506
    Abstract: Radiation curable acrylic compositions are improved with regard to flame resistance by incorporating a reactive compound which is the reaction product of tetrabromophthalic anhydride or acid and a (meth)acrylic compound.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: June 5, 2001
    Inventors: Mingxin Fan, Gary W. Ceska, James Horgan