The Nitrogen Is Not Bonded Directly To A Ring Patents (Class 560/37)
  • Patent number: 7375245
    Abstract: The present invention provides a compound of the following formula (I): wherein R1 is methyl or 4-aminobutyl, which may be acylated; X is phenyl or substituted phenyl; W is an esterified group removable by hydrogenolysis. Also disclosed is the preparation method and the application of formula (I) compound.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: May 20, 2008
    Assignee: Everlight USA, Inc.
    Inventors: Yu-Liang Liu, Rung-Tian Suen, Ying-Chi Chiu
  • Publication number: 20080076914
    Abstract: The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the deprotected product are carried out by the addition of a neutralisation agent. The deprotected product is buffered in a pH range suitable for subsequent autoclaving and formulation into an injectable radiopharmaceutical.
    Type: Application
    Filed: September 23, 2005
    Publication date: March 27, 2008
    Inventors: Julian Grigg, Nigel Osborn
  • Patent number: 7220876
    Abstract: Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side chains and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: May 22, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Christian Stapper, Heiner Glombik, Eugen Falk, Jochen Goerlitzer, Dirk Gretzke, Stefanie Keil, Hans-Ludwig Schaefer, Wolfgang Wendler
  • Patent number: 7208520
    Abstract: The present invention provides ethyl (?)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent ?3-adrenoceptor stimulating effects, therapeutic effects on pollakiuria or urinary incontinence and storage stabilities and are useful as a medicament.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: April 24, 2007
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Hidetoshi Isawa, Yukihiko Hotei, Kiyoshi Kasai, Junichi Sonehara, Satoshi Akahane, Hiromu Harada
  • Patent number: 7138538
    Abstract: Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiomers.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: November 21, 2006
    Assignee: Solvay (Societe Anonyme)
    Inventors: Thierry Delplanche, Roland Callens
  • Patent number: 7135586
    Abstract: Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: November 14, 2006
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Lieven Meerpoel, Leo Jacobs Jozef Backx
  • Patent number: 7057038
    Abstract: One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomeric mixture of a chiral substrate, e.g., a cyclic carbonate or cyclic carbamate; and a nucleophile, e.g., an alcohol, amine or thiol. A preferred embodiment of the present invention relates to a method for achieving the kinetic resolution of racemic and diastereomeric mixtures of derivatives of ?- and ?-amino, hydroxy, and thio carboxylic acids. In certain embodiments, the methods of the present invention achieve dynamic kinetic resolution of a racemic or diastereomeric mixture of a substrate, i.e.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: June 6, 2006
    Assignee: Brandeis University
    Inventors: Li Deng, Jianfeng Hang, Liang Tang
  • Patent number: 7030160
    Abstract: The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: April 18, 2006
    Assignee: Sanofi-Aventis
    Inventors: Laura Barzaghi, Philippe R. Bovy, Roberto Cecchi, Tiziano Croci, Stefano Romagnano
  • Patent number: 7015346
    Abstract: The invention provides a process for preparing a compound useful for inducing or maintaining general anesthesia or sedation in mammals.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: March 21, 2006
    Assignee: Theravance, Inc.
    Inventors: Thomas E. Jenkins, Sabine Axt, Jennifer Bolton
  • Patent number: 7015348
    Abstract: To provide a producing method of an optically active ?-amino acid useful as intermediate for the production of medicines, agricultural chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a high enantiomeric excess, without requiring additional procedures such as introduction and removal of protecting group and so on. A producing method of an optically active ?-amino acids which comprises subjecting an enamine to an asymmetric hydrogenation.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: March 21, 2006
    Assignee: Takasago International Corporation
    Inventors: Kazuhiko Matsumura, Xiaoyong Zhang, Takao Saito
  • Patent number: 6967220
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: November 22, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Ajita Bhat, Siegfried B. Christensen, IV, James S. Frazee, Martha S. Head, Jack D. Leber, Mei Li
  • Patent number: 6894076
    Abstract: New esters derived from (RR, SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate, analog to Tramadol, a process for obtaining them and the use of these compounds for the production of a medicament with analgesic properties. These new products of general formula (I) exhibit an analgesic activity higher than that of tramadol.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: May 17, 2005
    Assignee: Vita-Invest, S.A.
    Inventors: Marisabel Mourelle Mancini, Elisabet De Ramon Amat, Juan Huguet Clotet
  • Patent number: 6887866
    Abstract: The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: May 3, 2005
    Assignee: Theravance, Inc.
    Inventors: Thomas E. Jenkins, Sabine Axt, Jennifer Bolton
  • Patent number: 6875831
    Abstract: The invention pertains to a compound of formula (I), (II) or (III) wherein R1 and R2 are independently of each other hydrogen, C1-C18alkyl, C3-C18alkenyl, C3-C18alkinyl or phenyl which are unsubstituted or substituted by NO2, halogen, amino, hydroxy, cyano, carboxy, C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylamino or di(C1-C4alkyl)amino; A is a group capable of forming a stable free nitroxyl radical A*, which is bound via its oxygen atom to the carbon atom; Y is O, NR3 or CHR3—Xa, wherein Xa is O, S or NR3; R3 is hydrogen, C1-C18alkyl, C3-C18alkenyl, C3-C18alkinyl or phenyl which are unsubstituted or substituted by NO2, halogen, amino, hydroxy, cyano, carboxy, C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylamino or di(C1-C4alkyl)amino; Q1 is an organic or inorganic radical, derived from a compound having at least one functional group being capable of reacting with a hydroxy group; Q2 is an organic radical derived from a mono or polyfunctional alcohol, mono or polyfunctional aminoalcohol, mono or polyfunctional amine
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: April 5, 2005
    Assignee: CIBA Specialty Chemicals Corp.
    Inventors: Andreas Kramer, Peter Nesvadba, Marie-Odile Zink, Wiebke Wunderlich
  • Patent number: 6844448
    Abstract: The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive ?-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: January 18, 2005
    Assignee: President and Fellows of Harvard College
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Patent number: 6841183
    Abstract: N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-?-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspartame to a reductive alkylation reaction. These compounds may be purified by subjecting such a derivative containing one or more impurities to a crystallization step to crystallize the same. Further, there are provided a process for producing dialkoxychroman derivatives useful as intermediates for the production of such aspartame derivatives in the above process, and novel dialkoxychroman derivatives thus produced, which are excellent as the production intermediate.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: January 11, 2005
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kazutaka Nagashima, Shinji Fujita, Yuuichi Aoki, Shigeru Kawahara, Tadashi Takemoto, Eriko Ono
  • Patent number: 6835848
    Abstract: The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates for the production of highly active antibacterial quinolone medicaments.
    Type: Grant
    Filed: January 6, 2003
    Date of Patent: December 28, 2004
    Assignees: Ranbaxy Laboratories Limited, Toyama Chemical Co., Ltd.
    Inventors: Prosenjit Bose, Naresh Kumar, Taro Kiyoto
  • Publication number: 20040242686
    Abstract: The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent &bgr;3-adrenoceptor stimulating effects, therapeutic effects on pollakiuria or urinary incontinence and storage stabilities and are useful as a medicament.
    Type: Application
    Filed: March 12, 2004
    Publication date: December 2, 2004
    Inventors: Hidetoshi Isawa, Yukihiko Hotei, Kiyoshi Kasai, Junichi Sonehara, Satoshi Akahane, Hiromu Harada
  • Publication number: 20040242685
    Abstract: The present invention relates to N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives having the general formula I 1
    Type: Application
    Filed: July 19, 2004
    Publication date: December 2, 2004
    Inventors: John Richard Morphy, Zoran Rankovoc
  • Patent number: 6809207
    Abstract: The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, or thienyl group. The present invention further provides a method for synthesizing alpha-amino acids and derivatives thereof via a modified Ugi type reaction using an aldehyde, ammonium formate and a C1-C5 alkyl isocyanide. The compounds provided by this method are useful in the development of new pharmaceuticals for the treatment of human diseases.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: October 26, 2004
    Assignee: PharmaCore, Inc.
    Inventors: Sekar Alla, Seung-Yong Choi, Dale Dhanoa, Elso DiFranco, Galina Krokhina, Keqiang Li, Balasubramanian Thiagarajan, Wen-Chun Zhang
  • Patent number: 6794531
    Abstract: The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: September 21, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kazutaka Nagashima, Yuuichi Aoki, Tadashi Takemoto, Yusuke Amino, Nao Funakoshi, Eriko Ono
  • Publication number: 20040180953
    Abstract: The subject-matter of the invention is the B form of ethyl [(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino]-5,6,7,8-tetrahydronaphth-2-yloxy]acetate hydrochloride, of use as a medicament, which exhibits in particular the following physical characteristics:
    Type: Application
    Filed: May 3, 2004
    Publication date: September 16, 2004
    Inventors: Antoine Caron, Olivier Monnier, Sabarina Obert, Jerome Roche, Isabelle Ziri
  • Publication number: 20040176446
    Abstract: The invention relates to compounds of formula (I), to salts and stereoisomers thereof, to their production and to their use for producing medicaments used for treating cardiovascular diseases.
    Type: Application
    Filed: April 12, 2004
    Publication date: September 9, 2004
    Inventors: Cristina Alonso-Alija, Michael Harter, Michael Hahn, Josef Pernerstorfer, Stefan Weigand, Johannes-Peter Stasch, Frank Wunder
  • Publication number: 20040176445
    Abstract: The present application relates to novel potent PPAR-alpha-activating compounds for treating, for example, coronary heart disease, and to their preparation.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 9, 2004
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Klaus Urbahns, Michael Woltering, Susanne Nikolic, Josef Pernerstorfer, Berthold Hinzen, Elke Dittrich-Wengenroth, Hilmar Bischoff, Claudia Hirth-Dietrich, Klemens Lustig
  • Patent number: 6784311
    Abstract: Process for the preparation of 3-aminoalkanoic acid esters of the general formula: in which R is C1-6-alkyl and R1 is hydrogen, C1-6-alkyl or phenyl, or their salts, by catalytic hydrogenation of the corresponding 3-amino-2-alkenoic acid esters of the general formula: in which R and R1 have the above mentioned meanings. The hydrogenation is carried out in the presence of a strong acid and the salt of the 3-aminoalkanoic acid ester (I) and the strong acid formed is optionally converted into the free 3-aminoalkanoic acid ester (I) or into another salt in a manner known per se.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: August 31, 2004
    Assignee: Lonza AG
    Inventor: Rudolf Fuchs
  • Publication number: 20040138270
    Abstract: The present invention describes compounds of the general formula I 1
    Type: Application
    Filed: December 10, 2003
    Publication date: July 15, 2004
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Publication number: 20040122254
    Abstract: Disclosed are the compounds of formula I 1
    Type: Application
    Filed: December 4, 2003
    Publication date: June 24, 2004
    Inventors: Roger A. Fujimoto, Leslie W. McQuire, Benjamin B. Mugrage, John H. Van Duzer, Daqiang Xu
  • Publication number: 20040106653
    Abstract: The present invention relates to a compound formula [I]: 1
    Type: Application
    Filed: November 20, 2003
    Publication date: June 3, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Minoru Sakurai, Hitoshi Hamashima, Kouji Hattori
  • Patent number: 6743914
    Abstract: One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomeric mixture of a chiral substrate, e.g., a cyclic carbonate or cyclic carbamate; and a nucleophile, e.g., an alcohol, amine or thiol. A preferred embodiment of the present invention relates to a method for achieving the kinetic resolution of racemic and diastereomeric mixtures of derivatives of &agr;- and &bgr;-amino, hydroxy, and thio carboxylic acids. In certain embodiments, the methods of the present invention achieve dynamic kinetic resolution of a racemic or diastereomeric mixture of a substrate, i.e.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: June 1, 2004
    Assignee: Brandeis University
    Inventors: Li Deng, Jianfeng Hang, Liang Tang
  • Publication number: 20040077896
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Application
    Filed: October 14, 2003
    Publication date: April 22, 2004
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 6699463
    Abstract: Compounds of Formula I Each R is independently linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy or one R is H and the other R is linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy; R1 is selected from the group consisting of COCH3, CO2R3, CONH2, CONH(R4)2, CN, COX(CH2)n-N—(R2)(R4)(R3), and the quaternized salt form of the formula COX(CH2)n-N—(R2)(R4)(R3)+Y−; X is O or NH; n is an integer of 1 to 5; Y is an anion; and R2, R3 and R4 are independently linear or branched C1 to C20. Hair care formulations and other compounds containing compounds of Formula I, and methods for protecting hair and substrates such as polymers, textiles, fabrics, leathers and paints using the compounds herein.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: March 2, 2004
    Assignee: EM Industries
    Inventor: Ratan K. Chaudhuri
  • Patent number: 6699904
    Abstract: PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: March 2, 2004
    Assignee: Pfizer Inc.
    Inventors: Cheryl M. Hayward, David A. Perry
  • Publication number: 20040010020
    Abstract: A compound of Formula (IA) or Formula (IB) 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Martin Kirrane, Daniel Kuzmich, John Robert Proudfoot, David Thomson
  • Patent number: 6677360
    Abstract: The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have the formula (1) wherein R1, R2, U, V, A, B, W, R3, C and R4 have the meaning as defined in the claims.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: January 13, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Markus Albers, Klaus Urbahns, Andrea Vaupel, Michael Härter, Delf Schmidt, Beatrix Stelte-Ludwig, Christoph Gerdes, Elke Stahl, Jörg Keldenich, Ulf Brueggemeier, Klemens Lustig
  • Patent number: 6667314
    Abstract: The present invention provides compounds of the formula: wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or more fluorine atoms, or C3-6 cycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and R2 is phenyl optionally substituted by one or more fluorine atoms, to pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such compounds.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: December 23, 2003
    Assignee: Pfizer, Inc.
    Inventors: Manoussos Perros, David Anthony Price, Blanda Luzia Christa Stammen, Anthony Wood
  • Publication number: 20030216403
    Abstract: 1
    Type: Application
    Filed: May 14, 2003
    Publication date: November 20, 2003
    Inventors: Sarah Elizabeth Lively, Bohdan Waszkowycz, Martin James Harrison, Christopher Neil Farthing, Keith Michael Johnson
  • Publication number: 20030212292
    Abstract: The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions.
    Type: Application
    Filed: December 9, 2002
    Publication date: November 13, 2003
    Inventor: Claus O Meese
  • Patent number: 6645992
    Abstract: Compounds of formula I, in which R1, R2, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, for treating thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. Also disclosed are processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: November 11, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Manfred Schudok, Otmar Klingler, Hans-Peter Nestler, Hans Matter, Herman Schreuder
  • Patent number: 6627767
    Abstract: or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: September 30, 2003
    Assignee: Abbott Laboratories
    Inventors: Gang Liu, Yihong Li, David A. Janowick, Zhonghua Pei
  • Patent number: 6610710
    Abstract: Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to &agr;4&bgr;7 integrin and a selectivity toward &agr;4&bgr;1 integrin. They are used as therapeutic agents for various diseases to which &agr;4&bgr;7 integrin relates.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: August 26, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yasuhiro Tanaka, Toshihiko Yoshimura, Chieko Ejima, Mitsuhiko Kojima, Eiji Nakanishi, Hiroyuki Izawa, Yuko Satake, Nobuyasu Suzuki, Manabu Suzuki, Masahiro Murata
  • Publication number: 20030158253
    Abstract: This invention provides O-&agr;-acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): 1
    Type: Application
    Filed: December 10, 2002
    Publication date: August 21, 2003
    Applicant: Wyeth
    Inventors: John P. Yardley, Magid A. Abou-Gharbia, John W. Ullrich
  • Patent number: 6593345
    Abstract: The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: July 15, 2003
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Thomas Alan Crowell, Charles David Jones, Alan David Palkowitz
  • Publication number: 20030100754
    Abstract: This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.
    Type: Application
    Filed: August 26, 1997
    Publication date: May 29, 2003
    Inventors: HENRY UHLMAN BRYANT, THOMAS ALAN CROWELL, CHARLES DAVID JONES
  • Publication number: 20030096858
    Abstract: The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is administered.
    Type: Application
    Filed: November 18, 2002
    Publication date: May 22, 2003
    Inventor: Paul W. Erhardt
  • Publication number: 20030092747
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: June 13, 2002
    Publication date: May 15, 2003
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Publication number: 20030083518
    Abstract: The invention relates to substituted alcohol compounds of the formula (I): 1
    Type: Application
    Filed: June 27, 2002
    Publication date: May 1, 2003
    Inventors: Varghese John, Roy Hom, John Tucker
  • Publication number: 20030050324
    Abstract: This invention describes the new benzocycloheptenes of general formula I 1
    Type: Application
    Filed: September 11, 2002
    Publication date: March 13, 2003
    Applicant: Schering AG
    Inventors: Rolf Bohlmann, Jorg Kroll, Hermann Kuenzer, Christa Hegele-Hartung, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino
  • Publication number: 20030032671
    Abstract: The present application relates to novel potent PPAR-alpha-activating compounds for treating, for example, coronary heart disease, and to their preparation.
    Type: Application
    Filed: October 9, 2001
    Publication date: February 13, 2003
    Inventors: Klaus Urbahns, Michael Woltering, Susanne Nikolic, Josef Pernerstorfer, Berthold Hinzen, Elke Dittrich-Wengenroth, Hilmar Bischoff, Claudia Hirth-Dietrich, Klemens Lustig
  • Patent number: 6518450
    Abstract: The present invention reveals a novel structure of guaiacoxypropanolamines shown in formula I: The composition comprising formula I acts as active intergant and pharmaceutical acceptable vehicle. The composition by perfect administration routes in the mammal when given potential &agr;/&bgr;-adrenergic blocking, is selective for emergency hypertension.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: February 11, 2003
    Assignee: National Science Council
    Inventor: Ing-Jun Chen
  • Patent number: RE39593
    Abstract: 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: April 24, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Wolfgang Strassburger, Elmar Friderichs