Patent number: 6410592
Abstract: The present invention relates to aminomethylcarboxylic acid derivatives general formula (I), wherein Z is (CH2)n, O, S, SO, SO2 or N—R5; n is 0, 1 or 2; X represents 1-3 substituents independently selected from hydrogen, halogen, (C1-6)alkyloxy, (C3-6)cycloalkyloxy, (C6-12)aryloxy, (C6-12)aryl, thienyl, SR6, SOR6, SO2R6, NR6R6, NHR6, NH2, NHCOR6, NSO2R6, CN, COOR6 and (C1-4)alkyl, optionally substituted with halogen, (C6-12)aryl, (C1-6)alkyloxy or (C6-12)aryloxy; or 2 substituents at adjacent positions together represent a fused (C5-6)aryl group, a fused (C5-6)cycloalkyl ring or O—(CH2)m—O; m is 1 or 2; Y represents 1-3 substituents independently selected from hydrogen, halogen, (C1-4)alkyloxy, SR6, NR6R6 and (C1-4)alkyl, optionally substituted with halogen; R1 is COOR7 or CONR8R9; R2 and R6 are (C1-4)alkyl; R3, R4 and R5 are independently hydrogen or (C1-4)alkyl; R7, R8 and R9 are independently hydrogen, (C1-4)alkyl, (C6-12)aryl or arylalkyl; or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
January 25, 2001
Date of Patent:
June 25, 2002
Assignee:
Akzo Nobel N.V.
Inventors:
S. G. Gibson, D. R. Jaap, S. N. Thorn, R. R. Gilfillan
Patent number: 6310245
Abstract: The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I
where
R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, —OR5, —OCOR6, —OSO2R6, —SH, —S(O)nR7, —SO2OR5, —SO2NR5R8, —NR8SO2R6 or —NR8COR6;
R3 is hydrogen, alkyl, haloalkyl, alkenyl or alkynyl;
R4 is hydrogen, unsubstituted or substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, —COR9, —CO2R9, —COSR9 or —CONR8R9;
X is oxygen or sulfur;
Z is oxygen or NR8;
m is 0 or 1;
n is 0, 1 or 2;
R5 is hydrogen, alkyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl;
R6 is alkyl or haloalkyl;
R7 is alkyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl;
R8 is hydrogen or alkyl;
R9 is alkyl, alkenyl, alkynyl, phenyl or benzyl;
R10 is alkyl, haloalkyl, alkenyl or alkynyl;
Q is an unsubstituted or substituted cyclohexane-1,3-dione ring which is linked in the 2-position;
where m is 1 if R3 is
Type:
Grant
Filed:
June 23, 1999
Date of Patent:
October 30, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Uwe Kardorff, Regina Luise Hill, Michael Rack, Wolfgang von Deyn, Stefan Engel, Martina Otten, Matthias Witschel, Ernst Baumann, Joachim Rheinheimer, Guido Mayer, Ulf Misslitz, Karl-Otto Westphalen, Helmut Walter