Oxy, Not Bonded Directly To A Ring, In Same Side Chain As Ester Function Patents (Class 560/60)
  • Patent number: 5707544
    Abstract: The present invention is concerned with chromophore-containing photo cross-linkable liquid crystalline compounds having the formula ##STR1## wherein A.sup.1 and A.sup.2 each represent a cross-linkable, mesogenic group; andA.sup.3 represents a dichroic group.as well as liquid crystalline mixtures which contain such compounds and their use in the cross-linked state as optical components.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: January 13, 1998
    Assignee: Rolic AG
    Inventor: Stephen Kelly
  • Patent number: 5700393
    Abstract: The present invention is concerned with photo cross-linkable liquid crystalline compounds of the general formula ##STR1## wherein A.sup.1 and A.sup.2 each are a cross-linkable mesogenic residue; andA.sup.3 is (R,R)- or (S,S)-trans-1,2-cyclohexyl-diyl,liquid crystalline mixtures which contain such compounds and their use in the cross-linked state as optical components.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: December 23, 1997
    Assignee: Rolic AG
    Inventor: Stephen Kelly
  • Patent number: 5684186
    Abstract: A process for producing a phenyllactic acid derivative comprises hydrogenating a phenylpyruvic acid derivative in the presence of a catalyst containing at least one element selected from the Group VIII elements of the periodic table. The process provides a phenyllactic acid derivative useful as an intermediate in the production of pharmaceuticals and agricultural chemicals. The process uses as a starting material a phenylpyruvic acid derivative which is easily synthesized. The process is simpler in operation and provides a higher yield than conventional processes.
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: November 4, 1997
    Assignee: Nitto Chemical Industry Co., Ltd.
    Inventors: Hikari Morita, Hiroyuki Mori
  • Patent number: 5679285
    Abstract: Vinylene compounds of the formula I ##STR1## in which R, A.sup.1, Z.sup.1, X, L.sup.1, L.sup.2 and m have the meaning given in claim 1 are suitable as components of liquid-crystalline media.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: October 21, 1997
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ekkehard Bartmann, Sabine Schoen, Kazuaki Tarumi
  • Patent number: 5665773
    Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues for the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic compositions comprising said compounds.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: September 9, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Peter G. Klimko, John E. Bishop, Verney L. Sallee, Paul W. Zinke
  • Patent number: 5663370
    Abstract: Intermediates of formula (I), ##STR1## wherein R is H or CH.sub.3 ; processes for preparing them and their use as chemical intermediates, especially for preparing fungicidal acrylic ester derivatives.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: September 2, 1997
    Assignee: Zeneca Limited
    Inventors: Martin Charles Bowden, Stephen Martin Brown
  • Patent number: 5663128
    Abstract: Products are described which can be obtained by reacting components a), b), c) and d), where component a) is a compound of the formula I or a mixture of compounds of the formula I, component b) is a compound of the formula II or a mixture of compounds of the formula II, component c) is a compound of the formula III or a mixture of compounds of the formula III and component d) is a compound of the formula IV or a mixture of compounds of the formula IV, ##STR1## in which the general symbols are as defined in claim 1, the compound of the formula I being, for example, pentaerythritol, thiodiethylene glycol, 1,4-butanediol, 1,2-propanediol, diethylene glycol, triethylene glycol, diethanolamine or glycerol, the compound of the formula II being, for example, sunflower oil or coconut fat, the compound of the formula III being, for example, methyl 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propionate and the compound of the formula IV, being for example, sulfur or diisopropyl dithiophosphate.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: September 2, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Samuel Evans, Paul Dubs, Hugo Camenzind
  • Patent number: 5650533
    Abstract: The invention relates to 4-substituted isoxazole derivatives of formula I: ##STR1## wherein R, R.sup.1, R.sup.2, Q and n have the meaning defined in the description which possess valuable herbicidal properties.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 22, 1997
    Assignee: Rhone-Poulenc Agriculture Ltd.
    Inventors: David Alan Roberts, Susan Mary Cramp, Derek Ian Wallis, Jean-Paul Bulot
  • Patent number: 5648387
    Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: July 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
  • Patent number: 5637755
    Abstract: To provide a sulfonate represented by the following general formula (1A) which is useful as an organic peracid precursor in bleach compositions for domestic use, a process for producing it, and a bleach composition having no irritative smell, high bleaching power and excellent persistence of the bleaching power during the use: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, etc., R.sup.2 represents an alkylene group having 1 to 8 carbon atoms, a phenylene group, etc., R.sup.3 represents an alkylene group having 1 to 8 carbon atoms, R.sup.4 represents an alkylene group having 1 to 5 carbon atoms, p is 0 or 1, A represents an alkylene group having 2 to 4 carbon atoms, n is 1 to 100, and Ma represents an alkali metal atom. etc.
    Type: Grant
    Filed: December 5, 1995
    Date of Patent: June 10, 1997
    Assignee: Kao Corporation
    Inventors: Hiroshi Nagumo, Norio Nishikawa, Toyomi Koike, Yukinaga Yokota, Hiroyuki Yamada
  • Patent number: 5602273
    Abstract: A release tag reagent suitable for use in the chemical analysis of a substance to be detected comprises signal, release, and reactivity groups. A class of release tag compounds that are cleaved to release as signal groups very stable electrophoric ketones which are sufficiently volatile for determination in the gas phase of an analytical reaction mixture is disclosed.
    Type: Grant
    Filed: February 8, 1996
    Date of Patent: February 11, 1997
    Assignee: Northeastern University
    Inventors: Roger W. Giese, Samy Abdel-Baky, Linxiao Xu
  • Patent number: 5599963
    Abstract: The invention relates to catalysts for the synthesis of .beta.-hydroxy carbonyl compounds, and in particular to enantioselective catalysts.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: February 4, 1997
    Assignee: California Institute of Technology
    Inventors: Erick M. Carreira, Robert A. Singer
  • Patent number: 5585512
    Abstract: There is disclosed an ester compound that is resistant to decomposition in blood, but is quickly hydrolyzed in cancer cells, and functions as an anticancer agent. The ester compound has a structure represented by formula (I) or formula (II): ##STR1## wherein R.sub.1 represents a methyl group, a methoxy group, or a trifluoroacetamido group; R.sub.2 represents a phenyl group or a phenylmethyl group; and the absolute configuration of the asymmetric center marked with an asterisk is R.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: December 17, 1996
    Assignee: Director-General of Agency of Industrial Science and Technology
    Inventors: Yoshimitsu Yamazaki, Yoshikatsu Ogawa, Hiroaki Okuno
  • Patent number: 5585513
    Abstract: A compound of the formula: ##STR1## useful as an intermediate in the preparation of fungicides.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 17, 1996
    Assignee: Zeneca Limited
    Inventors: Ian R. Matthews, Christoher R. A. Godfrey, John M. Clough
  • Patent number: 5583249
    Abstract: Compounds of formula I are suitable for controlling and preventing infestation by microorganisms, insects and acarina on plants ##STR1## and their possible isomers and mixtures of isomers, whereina) X is CH.sub.2 F or CHF.sub.2,Y is CH andZ is OCH.sub.3, orb) X is CH.sub.2 F or CHF.sub.2,Y is a nitrogen atom andZ is OCH.sub.3 or NHCH.sub.3,and wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen, cyano, C.sub.1 -C.sub.12 alkyl, halo-C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.12 alkenyl, C.sub.2 -C.sub.12 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, cyclopropylmethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.12 alkoxyalkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkylthio, C.sub.2 -C.sub.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: December 10, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Albert Pfifner, Stephen Trah
  • Patent number: 5573999
    Abstract: .beta.-Substituted cinnamic acid derivatives of the formula 1, ##STR1## where R.sup.1 is alkyl, chlorine or bromine, --X-- is --O--, --S--, ##STR2## m is 0 or 1, --Y is --OR.sup.4, --O--N.dbd.CR.sup.5 R.sup.6, --NR.sup.7 R.sup.8, --N(OR.sup.9)R.sup.10 or --SR.sup.11, where the above-mentioned substituents R.sup.2 to R.sup.11 are alkyl, and R.sup.2, and R.sup.3 and R.sup.5 to R.sup.11 can also be hydrogen,Z is halogen, nitro, cyano, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, arylthioalkyl, hetarylalkyl, hetaryloxyalkyl, hetarylthioalkyl, alkenyl, aralkenyl, aryloxyalkenyl, arylthioalkenyl, hetarylalkenyl, hetaryloxyalkenyl, hetarylthioalkenyl, alkynyl, arylalkynyl, hetarylalkynyl, aryl, hetaryl, arylazo, acylamino, --OR.sup.12, --SR.sup.13, --SOR.sup.14, --SO.sub.2 R.sup.15, --COOR.sup.16, --CONR.sup.17 R.sup.18, --COR.sup.19, --CR.sup.20 .dbd.NR.sup.21, --N.dbd.CR.sup.22, R.sup.23, --CR.sup.24 .dbd.N--OR.sup.25, --CR.sup.25 R.sup.26 --O--, N.dbd.CR.sup.27 R.sup.28, --CH.sub.2 --OCOR.sup.39 or --NR.sup.37 R.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: November 12, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Hubert Sauter, Herbert Bayer, Klaus Oberdorf, Horst Wingert, Wolfgang von Deyn, Wassilios Grammenos, Hartmann Koenig, Harald Rang, Franz Roehl, Gisela Lorenz, Eberhard Ammermann
  • Patent number: 5567838
    Abstract: The present invention relates to a new method of making the dimethacrylate ester of alkoxylated bisphenol-A via transesterification with methyl methacrylate. This transesterification reaction proceeds at low temperatures and is driven by the removal of methanol as a methanol/saturated hydrocarbon azeotrope. The lower temperature reaction advantageously inhibits polyerization of the feed ester. The reaction is catalyzed by potassium based catalysts.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 22, 1996
    Assignee: Aristech Chemical Corporation
    Inventors: Joseph Pugach, Jeffrey S. Salek, John E. Aiken
  • Patent number: 5563161
    Abstract: Compounds of formula (I), and salt and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; R.sup.1 is H; optionally substituted C.sub.1-6 alkyl; optionally substituted phenyl(C.sub.1-4 alkyl); C.sub.2-6 alkenyl; C.sub.2-6 alkynyl; COR.sup.a ; COOR.sup.a ; COHet; COC.sub.1-6 alkylhalo; COC.sub.1-6 alkylNR.sup.a R.sup.b ; CONR.sup.12 C.sub.1-6 alkylCONR.sup.a R.sup.b ; CONR.sup.a R.sup.b ; or SO.sub.2 R.sup.a ; R.sup.2 represents H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; or R.sup.1 and R.sup.2 together form a chain (CH.sub.2).sub.q optionally substituted by oxo where q is 4 or 5 and where one methylene group may optionally be replaced by an oxygen atom or a group NR.sup.x, where R.sup.x is H or C.sub.1-6 alkyl; R.sup.3 is C.sub.1-3 alkyl substituted by optionally substituted phenyl; R.sup.4 and R.sup.5 are each H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; and Z represents O or S; are tachykinin receptor antagonists useful in therapy.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: October 8, 1996
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Ian T. Huscroft, Graeme I. Stevenson, Brain J. Williams
  • Patent number: 5530145
    Abstract: Novel anticholesteremic compounds capable of reducing blood cholesterol levels. Also included in this invention are (i) intermediates from which the abovementioned anticholesteremic compounds can be prepared, and (ii) methods for preparing both the intermediates and the anticholesteremic compounds.
    Type: Grant
    Filed: December 6, 1994
    Date of Patent: June 25, 1996
    Assignee: Syn-Tech Chem & Pharm Co., Ltd.
    Inventors: Hui-Po Wang, On Lee, Chin-Tsai Fan
  • Patent number: 5523460
    Abstract: A 4-fluorobiphenyl derivative of formula (I), which is useful as a cholesterol lowering agent or a lipid lowering agent because of its strong inhibitory effect on HMG-CoA reductase), and which is also useful as an intermediate for producing the above-mentioned cholesterol lowering agent or lipid lowering agent: ##STR1## wherein A is a .omega.-oxycarbonyldihydroxybutyl group, a tetrahydropyranyl group, a .omega.-oxycarbonyl-3-oxobutyl group, a formyl group, or a cyano group; R.sup.1 is a halogen atom, an alkyl group, or a group represented by R.sup.5 O--, wherein R.sup.5 is a hydrogen atom, or an alkyl group; R.sup.2 is a hydrogen atom, an alkyl group; R.sup.3 is a hydrogen atom, or an alkyl group; R.sup.5 and R.sup.2 may form a five-membered ring or a six-membered ring in combination with the oxygen atoms to which R.sup.5 and R.sup.2 are respectively bonded, and R.sup.5 and R.sup.3 may form a five-membered ring or a six-membered ring in combination with the oxygen atom to which R.sup.5 is bonded.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: June 4, 1996
    Assignee: Fujirebio Inc.
    Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Eiko Mori, Miwa Ishihara, Tetsuaki Yamaura, Misao Aoyama, Hiroshi Ikawa, Hisako Kobayashi
  • Patent number: 5516932
    Abstract: The present invention relates to compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen or an alkyl radical having 1 to 18 carbon atoms and optionally containing oxygen, nitrogen or halogen, the radicals X, Y and Z are identical and are a fluorine, bromine or iodine atom or if two of the radicals X, Y or Z are identical or all of the radicals X, Y, Z are different from each other, X, Y and Z are a fluorine, chlorine, bromine or iodine atom. The invention further relates to a process for the preparation of the compounds, by reacting an aryldiazonium salt of the formula ##STR2## in which the radicals X, Y and Z are identical and are a fluorine, bromine or iodine atom or, if two of the radicals X, Y and Z are identical or all of the radicals X, Y, Z are different from each other, X, Y and Z are a fluorine, chlorine, bromine or iodine atom and A.sup.(-) is an anion of an acid having a pK.sub.a <7, with a compound of the formula ##STR3## in which R.sup.
    Type: Grant
    Filed: January 6, 1994
    Date of Patent: May 14, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Matthias Beller, Hartmut Fischer, Laurent Weisse, Klaus Forstinger, Ralf Pfirmann, Heinz Strutz
  • Patent number: 5510371
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: April 23, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Sheo B. Singh, George M. Garrity, Olga Genillourd, Russell B. Lingham, Isabel Martin, Mary N. Omstead, Keith C. Silverman, Deborah L. Zink
  • Patent number: 5508275
    Abstract: Lipid-selective antioxidants of the formula I(A).sub.a (L)(X).sub.a, (I),in whichA=an antioxidative component,L=a bridging member,X=a lipophilic componenta and a'=independently of one another the numbers 1 or 2.The compounds are used for the protection of lipid-containing substances against oxidation and in pharmaceuticals for the prophylaxis and treatment of diseases in which bioradicals are involved, in particular of coronary, circulatory and vascular diseases.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: April 16, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus-Ulrich Weithmann, Gunther Wess, Dirk Seiffge
  • Patent number: 5481009
    Abstract: Methods of producing carboxylic acid ester derivatives of formulae (I) and (II), which are useful, for instance, as intermediates for producing an anti-hypercholesterolemic agent having an inhibitory effect on HMG-CoA Reductase: ##STR1## wherein R.sup.1 and R.sup.2 are independently a protective group for hydroxyl group, or R.sup.1 and R.sup.2 integrally constitute a protective group for hydroxyl groups; R.sup.3 is an alkyl group, or an aryl group; and R.sup.4 is a substituted aryl group, a substituted heterocyclic group, a substituted vinyl group, or a substituted cycloalkenyl group; and ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are respectively the same as defined in the above formula (I), are disclosed. In addition, intermediates for use in these methods of producing the carboxylic acid ester derivatives are disclosed.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: January 2, 1996
    Assignee: Fujirebio Inc.
    Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Eiko Mori, Hisako Kobayashi, Hiroshi Ikawa
  • Patent number: 5478964
    Abstract: The invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.
    Type: Grant
    Filed: December 10, 1992
    Date of Patent: December 26, 1995
    Assignee: Allied-Signal Inc.
    Inventor: Edmond Differding
  • Patent number: 5478875
    Abstract: Products are described which can be obtained by reacting components a), b) and c), where component a) is a compound of the formula I or a mixture of compounds of the formula I, component b) is a compound of the formula II or a mixture of compounds of the formula II and component c) is a compound of the formula III or a mixture of compounds of the formula III, ##STR1## in which the general symbols are as defined in claim 1, the compound of the formula I being, for example, pentaerythritol, thiodiethylene glycol, 1,4-butanediol, 1,4-propanediol, diethylene glycol, triethylene glycol, diethanolamine or glycerol, the compound of the formula II being, for example, sunflower oil or coconut fat, and the compound of the formula III being, for example, methyl 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propionate. The abovementioned products can be used as liquid antioxidants in polymers and lubricants.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: December 26, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Paul Dubs, Roger Martin, Samuel Evans
  • Patent number: 5466833
    Abstract: The invention relates to a novel process for the preparation of 13,14-dihydro-15 (R)-17-phenyl-18,19,20-trinor-PGF.sub.2.alpha. isopropyl ester of the formula (I)--wherein R stands for saturated or unsaturated straight, branched or cyclic C.sub.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: November 14, 1995
    Assignees: Kabi Pharmacia AB, Chinoin Ltd.
    Inventors: Jozsef Ivanics, Tibor Szabo, Istvan Hermecz, Gyula Dalmadi, Jozsefne Ivanics, Gaborne Kovacs, Resul Bahram
  • Patent number: 5453443
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of the PLA.sub.2 s enzymes. These compounds are useful as anti-allergic, anti-asthmatic, they are also useful in treating various inflammatory diseases such as rheumatoid arthritis, osteoarthritis, bursitis, psoriasis; immunoinflammatory disorders such as contact dermatitis, irritable bowel disease and the like.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: September 26, 1995
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Helene Perrier, Petpiboon Prasit, Ian Street, Zhaoyin Wang
  • Patent number: 5453464
    Abstract: This invention provides the use and preparation of certain 2,2'-diacetyl-bisacetoacetates and bis(beta-ketoesters). These compounds are useful in coating formulations as crosslinkers in conjunction with polyester, acrylic and/or other hydroxylated resins to provide coatings that cure at about 100.degree. and 175.degree. C. Certain combinations of these crosslinkers and resins cure at unusually low temperatures and provide films with good combinations of flexibility, hardness and adhesion.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: September 26, 1995
    Assignee: Eastman Chemical Company
    Inventors: J. Stewart Witzeman, Allen L. Crain
  • Patent number: 5453534
    Abstract: A process for the preparation of alkoxycarboxylic acid esters of the general formula I ##STR1## in which Y denotes CR.sup.4 R.sup.5 or CR.sup.4 R.sup.5 -CR.sup.6 R.sup.7,R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 denote C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.20 aralkyl, and C.sub.7 -C.sub.20 alkylaryl andR.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 can additionally denote hydrogen, and n is 0 or 1,by the reaction of hydroxycarboxylic acid esters of the general formula II ##STR2## in which R.sup.2, R.sup.3, R.sup.8, Y, and n have the aforementioned meanings, with alcohols of the general formula IIIR.sub.1 --OH (III),in which R.sup.1 has the aforementioned meanings, in the presence of heterogeneous catalysts at temperatures ranging from 100.degree. to 400.degree. C. and pressures ranging from 0.01 to 150 bar, wherein the heterogeneous catalysts used are zeolites and/or hydrothermally prepared phosphates.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: September 26, 1995
    Assignee: BASF Aktiengesellschaft
    Inventor: Karsten Eller
  • Patent number: 5438059
    Abstract: Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein R.sup.1 is optionally substituted aryl or optionally substituted heteroaryl; Y is oxygen, sulphur or NR.sup.4 ; R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, are hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkenyl; X is halogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.1-4 alkoxy, nitro or cyano; and n is 0 or an integer of 1 to 4; provided that when Y is oxygen, n is 0 and R.sup.1 is unsubstituted phenyl at least one of R.sup.2 and R.sup.3 is other than hydrogen or methyl.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: August 1, 1995
    Assignee: Zeneca Limited
    Inventors: John M. Clough, Christopher R. A. Godfrey, Paul J. de Fraine, Michael G. Hutchings, Vivienne M. Anthony
  • Patent number: 5434267
    Abstract: Process for the preparation of compounds of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X and n have the meaning given in the description, by reacting acetates with carbon monoxide in the presence of a basic auxiliary, followed by alkylation. The products are intermediates for fungicidal acrylates.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: July 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut Kraus, Alexander Klausener, Hans-Joachim Diehr
  • Patent number: 5433887
    Abstract: The invention discloses optically active liquid crystal compounds represented by the formulas [I], [II] and [III]: ##STR1## wherein R.sub.1 and R.sub.2 each represents an alkyl group of 4-18 carbon atoms, X represents O, COO or a single bond, and (A), (B), (C), (D) and (E) each represents ##STR2## in which l represents a halogen. The invention further discloses optically active liquid crystal compounds which are able to exhibit tristable states, represented by the formulas [IV], [V] and [VI]: ##STR3## wherein R.sub.1 ' and R.sub.2 ' each represents a straight chain alkyl group of 5-16 carbon atoms, X' represents O or COO and (A), (B), (C), (D) and (E), and l each has the same meaning as above.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: July 18, 1995
    Assignee: Showa Shell Sekiyu Kabushiki Kaisha
    Inventors: Tadaaki Isozaki, Hiroyuki Mogamiya, Shigenori Sakuma, Noriko Yamakawa
  • Patent number: 5424474
    Abstract: The present invention relates to fluorinated carboxylic acid esters of phosphono- and phosphinocarboxylic acids containing hydroxyl and/or mercapto groups, their use as waterproofing and/or oil-repellency agents, and a method for their preparation.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: June 13, 1995
    Assignee: Bayer AG
    Inventors: Klaus Pohmer, Rainer Weber, Hans-Dieter Block, Hans-Heinrich Moretto
  • Patent number: 5420160
    Abstract: There are described new 1-alkoxyhexatriene-2-carboxylates of the formula (I) ##STR1## in which R represents substituted phenyl,and a plurality of processes for their preparation.The new 1-alkoxyhexytriene-2-carboxylates are used as pesticides.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: May 30, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Gayer, Peter Gerdes, Heinz-Wilhelm Dehne, Stefan Dutzmann
  • Patent number: 5416068
    Abstract: .alpha.-Phenylacrylic acid derivatives I ##STR1## n=1; y=1;R.sup.1 =methylR.sup.2 =methyl, ethyl or methoxymethylR.sup.3 =H;R.sup.4 is 2,5-dimethylphenyl, 2,5-dichloropehnyl, 2-methyl-5-chlorophenyl, 2,4-dimethylphenyl, 2-chloro-5-methylphenyl, 2,3,5-trimethylphenyl or 2-methyl-5-isopropylphenyl.W=oxygen;A is --O--, --S--, --OCH.sub.2 --, --SCH.sub.2 --, --CH.dbd.CH--, --CO--OCH.sub.2 -- or --N(CH.sub.3) --CH.sub.2 --; methods for their preparation, agents containing them for combating injurious fungi and pests, and their use.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: May 16, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Wassilios Grammenos, Reinharad Kirstgen, Klaus Oberdorf, Hubert Sauter, Franz Roehl, Rainer Otter, Eberhard Ammermann, Gisela Lorenz, Uwe Kardorff, Christoph Kuenast
  • Patent number: 5414102
    Abstract: The present invention relates to fluorinated carboxylic acid esters of phosphonocarboxylic acids containing acrylate and/or methacrylate groups, their use as waterproofing or oil-repellency agents, and a method for their preparation.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: May 9, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Pohmer, Rainer Weber, Hans-Dieter Block, Hans-Heinrich Moretto
  • Patent number: 5412112
    Abstract: Novel 3-substituted derivatives of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids of formula (I) are prepared. These compouds are prepared from 2,2-dimethyl-5-substituted phenoxy-3-hydroxy-pentanoic acid-.beta.-lactones (formula II). The .beta.-lactones are prepared by condensing relevant phenoxypropanals with dimethylketene.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: May 2, 1995
    Assignee: Industrial Technology Research Institute
    Inventors: Hui-Po Wang, On Lee, Chin-Tsai Fan
  • Patent number: 5409954
    Abstract: .alpha.-arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; Y is a direct bond or oxygen;R.sup.1 is a mononuclear or dinuclear aromatic system substituted by C.sub.1 -C.sub.4 -alkyl, their preparation, insecticides and fungicides containing them and methods for their use.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: April 25, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Reinhard Kirstgen, Albrecht Harreus, Uwe Kardorff, Thomas Kuekenhoehner, Harald Rang, Gisela Lorenz, Eberhard Ammermann, Christoph Kuenast
  • Patent number: 5403952
    Abstract: Novel substituted cyclic compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophic epidermolysis bullosa, and coronary thrombosis associated with atherosclerotic plaque rupture. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also be useful as novel birth control agents by preventing ovulation or implantation.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: April 4, 1995
    Assignee: Merck & Co., Inc.
    Inventors: William Hagmann, Charles G. Caldwell, Paul R. Gooley
  • Patent number: 5399722
    Abstract: A novel process is described for preparing tert-butyl (3R, 5S ) 6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate of the formula I ##STR1## which is a valuable structural element for preparing inhibitors of HMG-CoA reductase.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: March 21, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Joachim-Heiner Jendralla, Kurt Kesseler
  • Patent number: 5399747
    Abstract: A new process for preparing aryl-substituted aliphatic carboxylic acids is provided. Aryl-substituted aliphatic ether or thioether compound is reacted with carbon monoxide in aqueous conditions at a temperature between about 25.degree. C. and about 200.degree. C. An acid such as hydrochloric acid may be added. As catalyst, a mixture of palladium or a palladium compound and a copper compound with at least one acid-stable ligand are present.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: March 21, 1995
    Assignee: Albemarle Corporation
    Inventors: Kannappan Chockalingam, Tse-Chong Wu
  • Patent number: 5389619
    Abstract: Compounds of the formula I ##STR1## where n, W, X, Y, Z, R.sup.1, R.sup.2, and R.sup.3 are as defined herein exhibit fungicidal, insecticidal, and acaracidal activity.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: February 14, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Reinhard Doetzer, Hubert Sauter, Horst Wingert, Reinhard Kirstgen, Albrecht Harreus, Gisela Lorenz, Eberhard Ammermann
  • Patent number: 5380915
    Abstract: A liquid-crystalline copolymer comprising the repeating units represented by the following general formulas ##STR1## wherein each of r and p is an integer of 2 to 5, q is an integer of 0 to 3, m is an integer of 1 to 20, and R.sup.1 is ##STR2## R.sup.2 being --COOR.sup.3, --OR.sup.3 or --OCOR.sup.3 R.sup.3, ##STR3## each of R.sup.4 and R.sup.5 being --CH.sub.3 or a halogen atom, each of a and d being an integer of 0 to 10, b being an integer of 0 or 1, with the proviso that d is not 0 when R.sup.5 is --CH.sub.3, the repeating units [I] and [II] being present in the liquid-crystalline copolymer in a substantial molar ratio [I]:[II] of 1:1, exhibits ferroelectricity even at a temperature neighboring room temperature and having a high response speed to changes of external electric fields.
    Type: Grant
    Filed: May 26, 1993
    Date of Patent: January 10, 1995
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Kazuharu Morita, Satoshi Hachiya, Fumio Moriwaki, Hiroyuki Endo
  • Patent number: 5376683
    Abstract: The invention relates to .DELTA..sup.8 - and .DELTA..sup.9 -prostaglandin derivatives of formula I, ##STR1## in which means the radicals or , R.sup.1 means ##STR2## COOR.sup.4 or CONHR.sup.5, R.sup.2 and R.sup.3 respectively mean a hydrogen atom or a hydroxy group, and the OH group can be respectively in alpha- or beta- position,means a CH.sub.2 group, an O or S atom,W means hydrogen, --OR.sup.6, halogen, --CN--, --NO.sub.2, trifluoromethyl or COOR.sup.6, and if R.sup.4 means hydrogen, their salts with physiologically compatible bases, the alpha-, beta- or gamma- cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and their pharmaceutical use.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: December 27, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Hartmut Rehwinkel, Helmut Vorbruggen, Karl H. Thierauch, Claus S. Sturzebecher
  • Patent number: 5373092
    Abstract: This invention relates to the production of derivatives of hydroxymethoxy mandelic acid (HMMA) and homvanillic acid (HVA), to their use in raising antibodies, and in the production of labelled compounds, and to the use of such materials in immunoassays for HMMA and HVA.
    Type: Grant
    Filed: September 15, 1993
    Date of Patent: December 13, 1994
    Assignee: Cancer Research Campaign Technology Limited
    Inventors: Gerard Gallacher, Geoffrey W. Mellor, Yee-Ping Ho
  • Patent number: 5371284
    Abstract: Phenyl acetylenic acetals and thioacetals and their use in the treatment of allergy, asthma, inflammation, arthritis, hyperproliferative skin disease, psoriasis or contact dermatitis are disclosed. Also disclosed are intermediates useful for producing said phenyl acetylenic acetals and thioacetals.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: December 6, 1994
    Assignee: Schering Corporation
    Inventors: Richard J. Friary, Michael J. Green, Anil K. Saksena, Vera A. Seidl
  • Patent number: 5371268
    Abstract: Ortho-substituted benzyl esters of cyclopropanecarboxylic acids I ##STR1## where X is N or CH and A is one of the following cyclopropane radicals: ##STR2## where R.sup.1 is CN, C.sub.2 -C.sub.8 -alkyl, CF.sub.3, C.sub.3 -C.sub.8 -alkenyl, (C.sub.1 -C.sub.4 -alkoxycarbonyl, unsubstituted or substituted phenyl-C.sub.1 -C.sub.6 -alkyl or phenyl-C.sub.3 -C.sub.6 -alkenyl, ethoxyphenyl, 2- or 3-bromophenyl, 2- or 4-trifluoromethylphenyl, 2,4- or 2,6-difluorophenyl, 2-fluoro-6-chlorophenyl, 2,4- or 2,6-dimethylphenyl, 2,3,6-trichlorophenyl or trimethylsilyl, R.sup.2 is H or halogen, R.sup.3 is unsubstituted or substituted phenyl, R.sup.4 is CH.sub.3 or halogen and Hal is halogen, with the proviso that X is CH when R.sup.1 is CF.sub.3 or trimethylsilyl, are suitable as fungicides and for controlling pests.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: December 6, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Franz Schuetz, Hubert Sauter, Norbert Goetz, Jochen Wild, Hans-Josef Wolf, Reinhard Doetzer, Gisela Lorenz, Eberhard Ammermann, Christoph Kuenast, Uwe Kardorff
  • Patent number: 5369109
    Abstract: The present invention provides optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids represented by the following formula: ##STR1## wherein R is a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group or a substituted vinyl group;Ar is a condensed aromatic group;X.sup.1 and Y.sup.1 are not the same and each is a hydrogen atom or a hydroxyl group; andX.sup.2 and Y.sup.2 are not the same and each is a hydrogen atom or a hydroxyl group or enantiomers thereof.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: November 29, 1994
    Assignee: Sagami Chemical Research Center
    Inventors: Tamejiro Hiyama, Tatsuya Minami, Takeshi Hanamoto, Guntoori B. Reddy
  • Patent number: 5362822
    Abstract: An adduct is prepared by reacting (A) a compound containing at least one epoxy group per molecule, with (B) a compound containing at least one epoxide reactive group per molecule selected from the group consisting of phenolic, thiol, secondary amine and carboxyl; wherein (i) when compound (A) is a polyepoxide, compound (B) contains a single epoxide reactive group per molecule; (ii) when compound (A) is a monoepoxide it is a monoglycidyl ether and compound (B) contains at least two epoxide reactive groups per molecule; and (iii) at least one of components (A) and (B) contains a rodlike mesogenic moiety. These adducts are useful in the preparation of polyurethanes.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: November 8, 1994
    Assignee: The Dow Chemical Company
    Inventor: Robert E. Hefner, Jr.