Aromatic Acid Moiety Patents (Class 560/8)
  • Publication number: 20100234610
    Abstract: Disclosed is a method for producing an optically active ester by highly selectively esterifying one enantiomer of a racemic carboxylic acid, while producing an optically active carboxylic acid which is the other enantiomer. An optically active ester is produced while producing an optically active carboxylic acid at the same time by reacting a racemic carboxylic acid with a specific alcohol or phenol derivative in the presence of benzoic anhydride or a derivative thereof and a catalyst such as tetramisole or benzotetramisole, thereby selectively esterifying one enantiomer of the racemic carboxylic acid.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 16, 2010
    Inventors: Isamu Shiina, Kenya Nakata
  • Publication number: 20100221656
    Abstract: A photosensitive compound has two or more structural units, in a molecule, represented by the following general formula (1): wherein R1 to R8 are selected from the group consisting of a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an acetoxy group, a phenyl group, a naphthyl group, and an alkyl group in which some or all of the hydrogen atoms are optionally replaced by fluorine atoms; R9 is a hydrogen atom or a hydroxyl group; X is a substituted or unsubstituted phenylene group or a substituted or unsubstituted naphthalene group; and Y is an oxygen atom or a single bond.
    Type: Application
    Filed: February 14, 2008
    Publication date: September 2, 2010
    Applicant: CANON KABUSHIKI KAISHA
    Inventor: Toshiki Ito
  • Patent number: 7786057
    Abstract: Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating, oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: August 31, 2010
    Assignee: Infineum International Limited
    Inventors: Tushar K. Bera, Jacob Emert, Jun Hua
  • Patent number: 7763691
    Abstract: Norbornene monomers with fluorene group and polymer material thereof are disclosed. The norbornene monomers with fluorene group are prepared by Diels-Alder reation. The Norbornene monomers containing fluorene groups are highly active for ring-opening-metathesis polymerization (ROMP), and the molecular weight and PDI value of the obtained polymers are controllable.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: July 27, 2010
    Assignee: National Taiwan University of Science & Technology
    Inventor: Der-Jang Liaw
  • Publication number: 20100168459
    Abstract: The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C1-C6 alkyl group or an aryl group which may optionally be substituted. This process comprises: (a) reacting a compound of formula (II), with a compound of formula (III), wherein R is as defined above and X is a leaving group, in the presence of N,N-di-isopropylethylamine.
    Type: Application
    Filed: June 5, 2007
    Publication date: July 1, 2010
    Applicant: SCHWARZ PHARMA LTD.
    Inventors: Seth C. Ennis, Roland Drews, Claus Meese
  • Publication number: 20100137250
    Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
    Type: Application
    Filed: November 9, 2009
    Publication date: June 3, 2010
    Inventors: Fariborz Firooznia, Paul Gillespie, Tai-An Lin, Eric Mertz, Achyutharao Sidduri, Sung-Sau So, Jenny Tan, Kshitij Chhabilbhai Thakkar
  • Patent number: 7718656
    Abstract: Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: May 18, 2010
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Valerio Chiroli, Wesley Kwan Mung Chong, Achim Hans-Peter Krauss, Michael Ross Niesman, Ennio Ongini
  • Publication number: 20100093955
    Abstract: The present invention relates to a photoreactive polymer that comprises a multi-cyclic compound in a main chain, and a polymerization method thereof. Since the photoreactive polymer according to the present invention comprises a multi-cyclic compound having a high glass transition temperature as a main chain, the thermal stability is excellent, and since the mobility of the main chain is relatively high as compared to that of an additional polymer, a photoreactive group can be freely moved in the main chain of the polymer. Accordingly, it is possible to overcome a slow photoreactive rate that is considered a disadvantage of a polymer material used to prepare an alignment film for known liquid crystal display devices.
    Type: Application
    Filed: March 21, 2008
    Publication date: April 15, 2010
    Inventors: Dai-Seung Choi, Hye-Young Jung, Sung-Ho Chun, Heon Kim, Sung-Don Hong, Dong-Woo Yoo
  • Patent number: 7682522
    Abstract: The invention includes compounds represented by Formula (1): wherein R represents hydrogen or methyl; A represents alkylene having from 1 to 12 carbon atoms, wherein in the alkylene, arbitrary —CH2— may be replaced by —O—, —S—, —CH?CH—, —CO—, —COO— or —OCO—; X and Y each independently represent an aromatic ring or a cyclohexane ring, wherein in the rings, arbitrary hydrogen may be replaced by alkyl having from 1 to 3 carbon atoms; Z independently represents a single bond, —O—, —S—, —COO—, —OCO—, —CON(R1)— or —N(R1)CO—, wherein R1 represents hydrogen or methyl; and m represents an integer of from 0 to 3.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: March 23, 2010
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventor: Mayumi Tanabe
  • Publication number: 20100040548
    Abstract: The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.
    Type: Application
    Filed: June 10, 2009
    Publication date: February 18, 2010
    Inventor: Chongxi Yu
  • Publication number: 20100029904
    Abstract: A carrier for use for separation purpose and a method for separation of a compound enable a chemical reaction to be performed in a liquid phase, a compound of interest to be separated from the liquid phase after the completion of the reaction readily, the separated compound to be evaluated by structural analysis or the like while the compound is being bound to the carrier, and the compound to be separated from the carrier readily. A carrier for separation is also provided which has a reaction site capable of reacting with other compound(s) on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.
    Type: Application
    Filed: September 20, 2006
    Publication date: February 4, 2010
    Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
  • Publication number: 20100009991
    Abstract: The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.
    Type: Application
    Filed: December 13, 2007
    Publication date: January 14, 2010
    Applicant: Astellas Pharma Inc.
    Inventors: Tadashi Terasaka, Tatsuya Zenkoh, Hisashi Hayashida, Hiroshi Matsuda, Junji Sato, Yoshimasa Imamura, Hiroshi Nagata, Norio Seki, Yoshiyuki Tenda, Mamoru Tasaki, Masahiro Takeda, Seiichiro Tabuchi, Minoru Yasuda, Kazunori Tsubaki
  • Patent number: 7635716
    Abstract: Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: December 22, 2009
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Todd S. Gac, Vinh X. Ngo
  • Publication number: 20090299076
    Abstract: To provide an axially asymmetric optically active biaryl ester compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. There is provided a method for producing an axially asymmetric ester compound, comprising a cycloaddition of a compound having a triple bond with the use of a catalyst containing rhodium metal and an optically active bisphosphine.
    Type: Application
    Filed: June 1, 2009
    Publication date: December 3, 2009
    Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY, TAKASAGO INTERNATIONAL CORPORATION
    Inventor: Ken Tanaka
  • Patent number: 7605178
    Abstract: Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: October 20, 2009
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Vinh X. Ngo
  • Patent number: 7585997
    Abstract: Compounds are disclosed with activity towards killing dysproliferative cells in vitro and treating cancer in vivo. Cancers such as cancer of the colon, pancreas, prostate, lung, breast, urinary bladder, skin and liver are exemplary. Compounds, pharmaceutical compositions and methods of use are described.
    Type: Grant
    Filed: December 31, 2004
    Date of Patent: September 8, 2009
    Assignee: Chesterford Enterprises Limited
    Inventor: Khosrow Kashfi
  • Publication number: 20090203773
    Abstract: The present invention relates to compounds of the formula (I); wherein R1 is H, CH3 or OCH3; R3=H, OH, CH3, OCH3, O-glucose or benzoyloxy; R4=H; R5=H or OH; R6=H or OCH3; R7=H, CH3, OCH3, cinnamoyloxy or (3,4,5-trimethoxy)-benzoyloxy; R8=H, OH, CH3 or OCH3; or R7 and R8 form together a group 0-CH2—O; R9=H or OCH3; R10=H or N-acetyl, N-methyl-2-aminoethyl; to their use as medicament for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X, to dietary and pharmaceutical compositions containing them and to a method for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X in animals including humans, said method comprising the step of administering an effective dose of a compound of the formula (I) to animals including humans which are in need thereof.
    Type: Application
    Filed: June 23, 2006
    Publication date: August 13, 2009
    Inventors: Daniel D'Orazio, Antoine De Saizieu, Goede Schuler, Ying Wang-Schmidt, Christof Wehrli, Swen Wolfram, Karin Wertz, Daniel Raederstorff
  • Publication number: 20090197198
    Abstract: Disclosed are a photosensitive compound containing oxime group which is directly decomposed by exposure to light, which is a molecular resist whose size is smaller than conventional polymer for photoresist, and a photoresist composition including the same. The photosensitive molecular compound has a structure represented by a following formula. In Formula, R1 is hydrogen atom or methyl group (CH3); Ra and Rb each is independently alkyl group of 1-6 carbon atoms, alkylcarbonyl group of 2-7 carbon atoms, aryl group of 6-10 carbon atoms or arylcarbonyl group of 7-11 carbon atoms, and Ra and Rb form one group as an united body, alkyl or cycloalkyl group of 1-20 carbon atoms or arylalkyl group of 7-20 carbon atoms which are doubly bonded to nitrogen atom.
    Type: Application
    Filed: January 29, 2009
    Publication date: August 6, 2009
    Inventors: Jung-Youl Lee, Jeong-Sik Kim, Eu-Jean Jang, Jae-Woo Lee, Jae-Hyun Kim
  • Publication number: 20090161516
    Abstract: The invention discloses novel dicyanostilbene derivatives bound to a methacrylic moiety that can serve as an active chromophore in a 3-dimensional optical memory, processes for its synthesis and its intermediates.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 25, 2009
    Applicant: MemPile Inc.
    Inventors: Andrew N. SHIPWAY, Nimer JABER, Moshe GREENWALD, Ariel LITWAK
  • Publication number: 20090149533
    Abstract: The invention provides novel omega-3 ester-based oil solutions of fenofibrate. These solutions are substantially free of any food effect, effective in small volumes, and readily bioavailable. Notably, because the solutions of the invention contain an omega-3 ester-based oil as the major ingredient, they not only provide an antihyperlipidemic effect due to the fenofibrate active ingredient, they also provide recommended daily dosages of omega-3 oils (i.e., approximately 1 gram of omega-3 oil per day), or a portion thereof.
    Type: Application
    Filed: August 4, 2005
    Publication date: June 11, 2009
    Applicant: TransForm Pharmaceuticals, Inc.
    Inventors: Orn Almarsson, Pasut Ratanabanangkoon, Julius Remenar, Hector Guzman
  • Patent number: 7524983
    Abstract: The present invention relates to the field of organic synthesis. More particularly it provides a process for making aromatic non-conjugated enol esters or enol ethers from an aromatic compound or moiety and a protected enal compound or moiety, such as an acetal or an acylal. The reaction is promoted by a salt of formula MX1-4, M representing a transition metal such as Zn or Fe and X representing a mono-anion, or by BY3, wherein Y represents a fluoride or a phenyl group optionally substituted.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: April 28, 2009
    Assignee: Firmenich SA
    Inventors: Roger Snowden, Anthony Birkbeck, Gary Womack
  • Patent number: 7514555
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: April 7, 2009
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Kirvin L. Hodge, Shalini Sharma, Reid W. von Borstel, Stephen D. Wolpe
  • Publication number: 20090069577
    Abstract: In one embodiment of the present invention, a silicon-based cross-coupling reagent is disclosed which is a highly stable tetraorganosilicon compound allowing for a cross-coupling reaction under mild reaction conditions without using fluoride ions, transition metal promoter, or strong bases, and the residue of the silicon reagent can be recovered and reused. The silicon-based cross-coupling reagent is a silicon compound in which an o-hydroxymethylphenyl group is connected to a silicon atom for intramolecular activation.
    Type: Application
    Filed: November 21, 2005
    Publication date: March 12, 2009
    Inventors: Yoshiaki Nakao, Tamejiro Hiyama
  • Publication number: 20090062149
    Abstract: Compounds represented by the following structural formulas can be used as photoacid generators: Such compounds are useful, for example, in fabricating arrays of polymers.
    Type: Application
    Filed: November 3, 2008
    Publication date: March 5, 2009
    Applicant: Affymetrix, INC.
    Inventors: Glenn H. McGall, Andrea Cuppoletti
  • Publication number: 20090054435
    Abstract: The present invention provides a compound represented by the formula: wherein each symbol is as defined in the specification. Since the compound of the present invention has superior hypoglycemic action and superior hypolipidemic action, it is useful as an agent for the prophylaxis or treatment of diabetes, hyperlipidemia, impaired glucose tolerance and the like.
    Type: Application
    Filed: July 28, 2006
    Publication date: February 26, 2009
    Inventor: Hiroshi Imoto
  • Publication number: 20090050844
    Abstract: A polymerizable liquid crystal composition of the present invention includes a compound including a repeated unit represented by a general formula (I) (wherein R1, R2, R3, and R4 each independently represents a hydrogen atom, a halogen atom, or a hydrocarbon group having 1 to 20 carbon atoms, and one or more of hydrogen atoms in the hydrocarbon group may be substituted by the halogen atoms.), in which a weight average molecular weight is 100 or more.
    Type: Application
    Filed: February 16, 2007
    Publication date: February 26, 2009
    Applicant: DIC CORPORATION
    Inventors: Osamu Yamazaki, Hiroshi Hasebe, Kiyofumi Takeuchi
  • Patent number: 7473705
    Abstract: The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I): wherein R1 to R3 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: January 6, 2009
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Narendra Panday, Hasane Ratni, Matthew Blake Wright
  • Patent number: 7462715
    Abstract: The present invention provides a 1,3,5-triazine compound represented by the following formula I: This compound can be synthesized easily and more economically and can be used as a dehydrating condensing agent having the property of accumulating at a water interface. In the case where carboxylic acid, amine, alcohol or other reaction substrate is amphiphilic, when mixing the dehydrating condensing agent of the present invention, which is amphiphilic, and the substrate to form various molecular aggregate phase including micelles in an aqueous solution, the substrate and the dehydrating condensing agent can be accumulated at the water interface. As a result, the concentration of the substrate increases locally at the water interface, and condensation reaction can be performed extremely efficiently.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: December 9, 2008
    Assignee: Japan Science and Technology Agency
    Inventor: Munetaka Kunishima
  • Publication number: 20080300261
    Abstract: Compounds of formula I are useful in treatment of diseases associated with the deposition of ?-amyloid in the brain.
    Type: Application
    Filed: July 19, 2005
    Publication date: December 4, 2008
    Inventors: Peter Blurton, Frank Burkamp, Ian Churcher, Timothy Harrison, Joseph Neduvelil
  • Publication number: 20080293764
    Abstract: A compound of the general formula (I): (wherein the symbols are as defined in the description), or a non-toxic salt thereof.
    Type: Application
    Filed: April 30, 2008
    Publication date: November 27, 2008
    Inventors: Masahiko Terakado, Shinji Nakade, Takuya Seko, Yoshikazu Takaoka
  • Publication number: 20080293695
    Abstract: Drug substances comprising a pharmaceutically acceptable organic acid addition salt 6f amine containing pharmaceutically active compounds useful for the treatment of a therapeutic ailment administration and exhibiting prophylactic properties when employed in non-therapeutic administration.
    Type: Application
    Filed: May 22, 2007
    Publication date: November 27, 2008
    Inventors: David William Bristol, Clifford Riley King, Joseph Pike Mitchener, JR., Vicki Haynes Audia
  • Publication number: 20080287441
    Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
    Type: Application
    Filed: April 22, 2008
    Publication date: November 20, 2008
    Applicant: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
  • Patent number: 7442796
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: October 28, 2008
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 7442418
    Abstract: The present compound represented by formula(I) CH2?CR1—COO—(L)k-E1-E2-E3-(E4)m-(E5)n-R2??(1) provided that the symbols in the formula have the following meanings: R1: a hydrogen atom or a methyl group; R2: a C1-8 alkyl group; L: —(CH2)pO—, —(CH2)q—, -Cy-COO— (Cy is a trans-1,4-cyclohexylene group), -Cy-OCO—, -E6-(CH2)2—, -E7-CH2O— or -E8-O— (wherein each of p and q which are independent of each other, is an integer of from 2 to 8); E1, E2, E3 E4, E5, E6, E7, E8: each independently a 1,4-pheneylene group or a trans-1,4-cyclohexylene group (provided that at least one of E1, E2 and E3 is a trans-1,4-cyclohexylene group, and in a case where L is -Cy-OCO—, E1 is a trans-1,4-cyclohexylene group),and k, m, n: each independently 0 or 1, provided that when k is 1 and L is -Cy-COO—, -Cy-OCO—, -E6-(CH2)2—, -E7-CH2O— or -E8-O—, at least one of m and n is 0. The present compound is useful for liquid crystal composition and optical element.
    Type: Grant
    Filed: December 26, 2006
    Date of Patent: October 28, 2008
    Assignee: Asahi Glass Company, Limited
    Inventors: Yuriko Kaida, Hiromichi Nagayama, Hiroshi Kumai
  • Publication number: 20080257493
    Abstract: The invention is based on the discovery that certain well-defined compounds derived from pentacyclopentadecane dimethanol are useful components in adhesive formulations. In particular, the invention compounds described herein provide high Tg values and low shrinkage. Compounds of the invention are useful as adhesives for use in the semiconductor packaging industry.
    Type: Application
    Filed: April 9, 2008
    Publication date: October 23, 2008
    Inventor: Stephen M. Dershem
  • Publication number: 20080234370
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: February 4, 2005
    Publication date: September 25, 2008
    Inventors: Robert W. Marquis, Joshi M. Ramanjulu
  • Publication number: 20080221350
    Abstract: Process for preparing compounds by cross-coupling of enolizable carbonyl compounds, nitriles or their analogues with substituted aryl or heteroaryl compounds in the presence of a Brönsted base and of a catalyst or precatalyst containing a.) a transition metal, a complex, a salt or a compound of this transition metal from the group V, Mn, Fe, Co, Ni, Rh, Pd, Ir, Pt) and b.) at least one sulphonated phosphane ligand in a solvent or solvent mixture.
    Type: Application
    Filed: September 12, 2006
    Publication date: September 11, 2008
    Inventors: Andreas Meudt, Sven Nerdinger, Bernd Wilhelm Lehnemann, Till Vogel, Victor Snieckus
  • Patent number: 7411084
    Abstract: The present invention relates to a method of preparing a phenoxy alkanoic, alkenoic, or alkynoic acid or a salt thereof from a phenoxy containing compound via a dicarboxylate intermediate. The phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof prepared by this method are suitable for use in composition for delivering active agents via oral or other routes of administration to animals. Furthermore, the present invention relates to phenoxy dicarboxylic acids and their salts for delivering active agents, such as biologically or chemically active agents, to a target.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: August 12, 2008
    Assignee: Emisphere Technologies, Inc.
    Inventor: Joseph N. Bernadino
  • Publication number: 20080169448
    Abstract: To provide a liquid crystalline composition, which can be obtained by mixing a plurality of liquid crystalline composition search of which can exhibit different liquid crystal phases from one another, being capable of exhibiting a biaxial liquid crystal phase, a liquid crystalline composition contains a liquid crystalline composition R which exhibits a liquid crystal phase having a positive birefringence; and a liquid crystalline composition D which exhibits a liquid crystal phase having a negative birefringence, in which the liquid crystalline composition R comprises a compound having a rectangular plate-like shape.
    Type: Application
    Filed: March 12, 2008
    Publication date: July 17, 2008
    Applicant: FujiFilm Corporation
    Inventors: Hideyuki Nishikawa, Atsuhiro Ohkawa
  • Patent number: 7378539
    Abstract: Classes of molecules are disclosed which can, for example, be used in molecular switches. The classes of molecules include at least three segments—an electronic donor (“D”), a switchable bridge (“B”), and an electronic acceptor (“A”)—chemically connected and linearly arranged (e.g., D-B-A). The electronic donor can be an aromatic ring system with at least one electron donating group covalently attached; an aromatic ring system with an electron withdrawing group covalently attached is usually employed as the electronic acceptor; and the switchable bridge can be a pi system that can be switched on or off using an external electric field.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: May 27, 2008
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Sean X. Zhang, Zhang-Lin Zhou, Kent Vincent, R. Stanley Williams
  • Patent number: 7375245
    Abstract: The present invention provides a compound of the following formula (I): wherein R1 is methyl or 4-aminobutyl, which may be acylated; X is phenyl or substituted phenyl; W is an esterified group removable by hydrogenolysis. Also disclosed is the preparation method and the application of formula (I) compound.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: May 20, 2008
    Assignee: Everlight USA, Inc.
    Inventors: Yu-Liang Liu, Rung-Tian Suen, Ying-Chi Chiu
  • Patent number: 7329770
    Abstract: The instant invention relates to the discovery of certain novel herbicidal esters of agriculturally active acids. These esters present agronomical advantages over traditional herbicidal products by presenting multiple herbicidal mechanisms that ensure activity over a broad weed spectrum while limiting the appearance of plant resistance.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: February 12, 2008
    Inventor: Joel Marcel Coret
  • Patent number: 7323584
    Abstract: The invention relates to a process for preparing N-(4?-cyano-3?-trifluoromethylphenyl)-3-(4?-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide (bicalutamide).
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: January 29, 2008
    Assignees: Helm AG, CF Pharma Gyogyszergyarto KFT
    Inventors: Ádám Bor, György Orosz, Ferenc Lukács, Géza Schneider
  • Patent number: 7294369
    Abstract: The invention relates to new polymerisable mesogenic or liquid crystalline compounds comprising a laterally substituted cinnamate group, to polymerisable mesogenic or liquid crystalline mixtures and anisotropic polymers prepared thereof, and to the use of the new compounds and the mixtures and polymers prepared thereof in optical and electrooptical devices, adhesives, synthetic resins with anisotropic mechanical properties, cosmetics, diagnostics, liquid crystal pigments, decorative and security applications, nonlinear optics, optical information storage, electronic devices like organic field effect transistors (FET or OFET), electroluminescent devices, or as chiral dopants.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: November 13, 2007
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Richard Harding, Ian Victor Edward Hassall, Shirley Ann Marden, Darren Brown
  • Patent number: 7273946
    Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: September 25, 2007
    Assignee: Nicox S.A.
    Inventors: Eninnio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
  • Patent number: 7259278
    Abstract: It is presently accepted that the mechanism of action for all anti-tumor tubulin ligands involves the perturbation of microtubule dynamics during the G2/M phase of cell division and subsequent entry into apoptosis (1). In this invention, we report a novel tubulin ligands which have a unique mechanism of action. These compounds, halogenated derivatives of acetamido benzoyl ethyl ester (HAABE), arrest cancer cells in S-phase and cause cell death by a combination of apoptosis (DNA ladder) and necrosis (DNA degradation) type mechanisms. Normal cells are not affected at the same concentrations of compound. The ligands bind covalently to tubulin in vitro and in vivo and shows potent cancericidal activity in tissue culture assays and in animal tumor models. These compounds target early S-phase at the G1/S transition rather than the G2/M phase and mitotic arrest.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: August 21, 2007
    Assignee: Cytoskeleton Inc.
    Inventors: Ashley Stuart Davis, Kim Maria Middleton, Jain Dong Jiang, J. George Bekesi
  • Patent number: 7241898
    Abstract: The present invention relates to new compounds of formula 1, the preparation thereof, intermediate products for preparing them and the use of the compounds of formula 1 as catalysts in various metathesis reactions The new metathesis catalysts, which are obtained from readily accessible preliminary products, have a high activity and can be used for all kinds of metathesis reactions.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: July 10, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Dieter Arlt
  • Publication number: 20070155981
    Abstract: Provided is an arylene derivative including a polar functional group represented by Formula 1: An arylene derivative including a polar functional group has excellent solubility in an organic solvent. A soluble compound of the arylene derivative can be used to form a thermally stable organic layer which can be used to form an organic light emitting device having low operating voltage, high efficiency, and excellent brightness.
    Type: Application
    Filed: December 4, 2006
    Publication date: July 5, 2007
    Inventors: Dong-Woo Shin, Woon-Jung Paek, Tae-Yong Noh, O-Hyun Kwon, Jong- Jin Park, Myeong-Suk Kim, Byoung-Ki Choi
  • Patent number: 7238834
    Abstract: The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is —COOH or —COOR4; R4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 3, 2007
    Assignee: AMR Technology, Inc.
    Inventor: Thomas E. D'Ambra
  • Patent number: 7223881
    Abstract: The present invention relates to an improved process for the preparation of novel antidiabetic compounds having formula (1) where R1 represents hydrogen or lower alkyl group and X represents hydrogen or halogen atom
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: May 29, 2007
    Assignee: Dr. Reddy's Laboratories Limited
    Inventors: Mahender Rao Siripragada, Prabhakar Chebiyyam, Rajender Kumar Potlapally, Chandra Sekhar Batchu, Ramabhadra Sarma Mamillapalli, Om Reddy Gaddam