Patent number: 6426364
Abstract: Provided, among other things, is a compound of Formula I:
wherein:
Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of
alkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, alkanoyl, thioalkyl, aralkyl, aralkyloxy, aryloxyalkyl, aryloxyalkoxy, cycloalkyl-substituted alkyl, cycloalkyloxy-substituted alkyl, cycloalkyl-substituted alkoxy, cycloalkyloxy-substituted alkoxy, heterocycloalkyl-substituted alkyl, heterocycloalkyloxy-substituted alkyl, heterocycloalkyl-substituted alkoxy, heterocycloalkyloxy-substituted alkoxy, thioaryl, aralkylthio, thioarylalkyl, aralkylthioalkyl, halo, NO2, CF3, CN, OH, alkylenedioxy, SO2NRR′, NRR′, CO2R (where R and R′ are independently selected from the group consisting of H and alkyl), and a second aryl group, which may be substituted as above;
R1 is selected from the group consisting of H and alkyl;
R2 is selec
Type:
Grant
Filed:
November 1, 2000
Date of Patent:
July 30, 2002
Assignee:
NPS Allelix Corp.
Inventors:
Ian Egle, Jennifer Frey, Methvin Isaac
Patent number: 6310245
Abstract: The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I
where
R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, —OR5, —OCOR6, —OSO2R6, —SH, —S(O)nR7, —SO2OR5, —SO2NR5R8, —NR8SO2R6 or —NR8COR6;
R3 is hydrogen, alkyl, haloalkyl, alkenyl or alkynyl;
R4 is hydrogen, unsubstituted or substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, —COR9, —CO2R9, —COSR9 or —CONR8R9;
X is oxygen or sulfur;
Z is oxygen or NR8;
m is 0 or 1;
n is 0, 1 or 2;
R5 is hydrogen, alkyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl;
R6 is alkyl or haloalkyl;
R7 is alkyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl;
R8 is hydrogen or alkyl;
R9 is alkyl, alkenyl, alkynyl, phenyl or benzyl;
R10 is alkyl, haloalkyl, alkenyl or alkynyl;
Q is an unsubstituted or substituted cyclohexane-1,3-dione ring which is linked in the 2-position;
where m is 1 if R3 is
Type:
Grant
Filed:
June 23, 1999
Date of Patent:
October 30, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Uwe Kardorff, Regina Luise Hill, Michael Rack, Wolfgang von Deyn, Stefan Engel, Martina Otten, Matthias Witschel, Ernst Baumann, Joachim Rheinheimer, Guido Mayer, Ulf Misslitz, Karl-Otto Westphalen, Helmut Walter
Patent number: 6265603
Abstract: Peptidomimetic isoprenyl transferase inhibitors R6SCHR1′CHR1WCHR2YC(:X)NR3CHR5COR4 wherein R1=OH, H, alkyl, amino group or R1 and R6 together form a heterocyclic ring; R1′=H, alkyl, aryl; R2=H, alkyl, arylalkyl, heteroarylalkyl; R3=H, alkyl, arylalkyl; R4=OH, alkoxy, amino group; R5=natural amino acid residue or D—E—F, where D is alkyl or alkenyl, E is O, S, N, or null, F is H, alkyl, aryl, carboxy amino, etc.; R6=H, alkyl, acyl, etc.; W=alkyl, alkenyl; X=O, S, Y is M—O—P, where M is C0-6 alkyl, O is oxygen-C0-4 alkyl, P is(un)substituted C6-20 aryl are disclosed.
Type:
Grant
Filed:
April 1, 1999
Date of Patent:
July 24, 2001
Assignee:
Eisai Co., Ltd.
Inventors:
Michael D. Lewis, Ana Maria Garcia, James J. Kowalczyk, Hu Yang, Eric Schwartz
Patent number: 6048660
Abstract: Compounds of the formula I ##STR1## in which R.sub.1 and R.sub.2 independently of one another are, for example, a group of the formula II ##STR2## R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 independently of one another are, for example, hydrogen, C.sub.1 -C.sub.12 alkyl, OR.sub.8, SR.sub.9, NR.sub.10 R.sub.11, halogen or phenyl; R.sub.8, R.sub.9, R.sub.10, R.sub.11 independently of one another are, for example, hydrogen or C.sub.1 -C.sub.12 alkyl; R.sub.12 is, for example, C.sub.1 -C.sub.8 alkyl; R.sub.13 is, for example, C.sub.1 -C.sub.12 alkyl; R.sub.14 is, for example, hydrogen; Y is C.sub.1 -C.sub.12 alkylene, C.sub.4 -C.sub.8 alkenylene, C.sub.4 -C.sub.8 alkynylene or cyclohexylene, or is phenylene or C.sub.4 -C.sub.40 alkylene interrupted one or more times by --O--, --S-- or --NR.sub.15 --, or Y is a group of the formula III, IV, V, VI, VII, VIII, IX, X or XI ##STR3## Y.sub.1 is as defined for Y with the exception of the formula V; R.sub.15 is hydrogen, C.sub.1 -C.sub.12 alkyl or phenyl; and R.sub.
Type:
Grant
Filed:
January 28, 1998
Date of Patent:
April 11, 2000
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
David George Leppard, Manfred Kohler