Oxy, Bonded Directly To A Ring, In Same Side Chain As Carboxyl, Or Salt Thereof Patents (Class 562/471)
  • Patent number: 6730798
    Abstract: Compounds of formula (II) are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is converted into a hydroxylactone and then the hydroxy group into a leaving group, the leaving group is replaced with azide, the lactone amidated and then the azide converted to the amine group, in order to obtain compounds of formula (I).
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: May 4, 2004
    Assignee: Speedel Pharma AG
    Inventors: Stefan Stutz, Peter Herold, Felix Spindler
  • Patent number: 6602878
    Abstract: Acylquanidines of the formula wherein the substituents are defined as in the specification which are antagonists of the vitronectin receptor and inhibitors of cell adhesion and bone resorption mediated by the osteoclasts.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: August 5, 2003
    Assignees: Aventis Pharma S.A., Genentech, Inc.
    Inventors: Denis Carniato, Thomas R. Gadek, Jean-Francois Gourvest, Jochen Knolle, Anurschirwan Peyman, Jean-Marie Ruxer, Sarah C. Bodary
  • Patent number: 6603040
    Abstract: Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X1 and X2 can independently be aryl ketones, such as those selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: August 5, 2003
    Assignee: SurModics, Inc.
    Inventor: Dale G. Swan
  • Patent number: 6576663
    Abstract: Compositions and methods for the treatment of dry eye and related diseases utilizing 6-keto-PGF1&agr; and its analogs are disclosed.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: June 10, 2003
    Assignee: Alcon, Inc.
    Inventor: Peter G. Klimko
  • Patent number: 6541473
    Abstract: The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: April 1, 2003
    Assignee: Warner Lambert Company
    Inventors: Stuart E. Bradley, Eric W. Collington, Matthew C. Fyfe, William T. Gattrell, Joanna V. Geden, Peter J. Murray, Martin J. Procter, Robert J. Rowley, Jonathan G. Williams
  • Patent number: 6525093
    Abstract: Compounds are provided that lower blood glucose concentrations, lower serum triglyceride concentrations, lower systolic blood pressure, and increase glucose uptake by adipose tissue, but do not affect the expression of PPAR-&ggr; by adipose tissue.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: February 25, 2003
    Assignee: Calyx Therapeutics Inc.
    Inventors: Partha Neogi, Bishwajit Nag, Frederick J. Lakner, Debendranath Dey, Satyanarayana Medicherla
  • Publication number: 20030013911
    Abstract: The present invention relates to production of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid useful as an intermediate for pharmaceutical products, by an industrial means, economically, safely in a good yield. Novel 2-(2′-cyclohexen-1′-yl)-2-hydroxy-2-phenylacetic acid ester obtained by reacting cyclohexene and benzoylformic acid ester in the presence of a Lewis acid is hydrolyzed and reduced to give 2-cyclohexyl-2-hydroxy-2-phenylacetic acid.
    Type: Application
    Filed: November 6, 2001
    Publication date: January 16, 2003
    Applicant: Sumika Fine Chemicals Co., Ltd.
    Inventors: Tetsuya Ikemoto, Wei-Guo Gao, Mitsuhiro Takeda, Masami Igi
  • Patent number: 6495715
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: December 17, 2002
    Assignee: Warner-Lambert Company
    Inventors: Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder
  • Patent number: 6492550
    Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, X1, R1, R2, Ra and Rb are as defined in the specification.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: December 10, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Serge Plamondon, Yonghua Gai, Neelakantan Balasubramanian
  • Patent number: 6482852
    Abstract: This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula as defined herein.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: November 19, 2002
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: William C. Shakespeare, Michael G. Yang, Rajeswari Sundaramoorthi, Regine Bohacek, Charles Joseph Eyermann, Tomi K. Sawyer
  • Patent number: 6342592
    Abstract: The invention relates to a method which comprises synthesising bifunctional compounds then chiral compounds from the bifunctional compounds, also to synthesising supports comprising these chiral compounds, and the use of these supports for preparing or separating enantiomers, or for asymmetric synthesis. The invention also relates to bifunctional compounds, their use as a source of functionalised polymers, and to the chiral compounds, also to the use of these chiral compounds in a chiral support in the form of a three-dimensional network or for separating or preparing enantiomers, principally for analytical or preparative chromatography, and in a support for the production of chiral molecules by asymmetric synthesis.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: January 29, 2002
    Assignee: Institut Francais du Petrole and Chiralsep
    Inventors: Raphaƫl Duval, Hubert Leveque
  • Patent number: 6340762
    Abstract: A method for producing an optically active piperidine carboxylic acid derivative, which comprises subjecting a piperidine carboxylic acid derivative of the formula (1): wherein Z is a protecting group for the carboxyl group, to optical resolution by means of an optical resolution agent of the formula (2): wherein symbol * indicates that the designated carbon atom is asymmetric.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: January 22, 2002
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Isao Hashiba, Masami Kozawa, Kiyotomo Seto
  • Patent number: 6337306
    Abstract: Phenoxyacetic acid derivatives of the formula: wherein R1, R2, Xn and A are as defined herein, and a process for preparing the derivatives. The derivatives are used as herbicides.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: January 8, 2002
    Assignee: Rhone-Poulenc Agro
    Inventors: Norio Sasaki, Atsushi Go, Hideshi Mukaida, Yukiko Oe
  • Publication number: 20020002290
    Abstract: 1
    Type: Application
    Filed: June 14, 2001
    Publication date: January 3, 2002
    Applicant: Secretary of State for Defence in her Britannic Majesty's Government of the United Kingdom
    Inventors: Graeme P. Nicholson, Mark J. Kan, Gareth Williams, Michael G. Drew, Paul D. Beer
  • Patent number: 6316666
    Abstract: A method for producing phenylenedioxydiacetic acids of high purity at high yield from crude phenylenedioxydiacetic acids which mainly contains phenylenedioxydiacetic acids represented by the following general formula (I): wherein, R represents a hologen, carboxyl group or hydrocarbon group having 1-4 carbon atoms, and n represents an integer from 0 to 3, wherein an alkaline aqueous solution of the crude phenylenedioxydiacetic acids is mixed with a mineral acid to precipitate the phenylenedioxydiacetic acids, wherein at least 10% by weight of the alkaline aqueous solution is mixed with a mineral acid at 0 to 50° C.; and, after completion of the mixing, the temperature of the mixture is kept at 80 to 110° C.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: November 13, 2001
    Assignee: Sumitomo Chemical Company, Ltd.
    Inventors: Junji Morimoto, Takashi Kamikawa, Hiroshi Ueda
  • Patent number: 6294580
    Abstract: A compound having formula (I), wherein A is selected from the group consisting of: (i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C1-6alkyl, C1-3alkoxy, C1-3fluoroalkoxy, nitrile, or —NR7R8 where R7 and R8 are independently hydrogen or C1-3alkyl; (ii) a 5- or 6-membered hetrocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur; and (iii) a fused bicyclic ring (a), wherein ring C represents a heterocyclic group as defined in point (ii) above, which bicyclic ring is attached to group B via a ring atom of ring C; B is selected from the group consisting of: (iv) C1-6alkylene; (v) —MC1-6alkylene or C1-6alkyleneMC1-6alkylene, wherein M is O, S, or —NR2 wherein R2 represents hydrogen or C1-3alkyl; (vi) a 5- or 6-membered heterocyclic group containing at least one nitrogen heteroatom and optionally at least one further heteroatom selected from oxygen, nitrogen and sulfur and optionally substituted by C1-3alkyl; and (vii) H
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: September 25, 2001
    Assignee: Glaxo Wellcome Inc.
    Inventors: Timothy Mark Willson, Robert Anthony Mook, Istvan Kaldor, Brad Richard Henke, David Norman Deaton, Jon Loren Collins, Jeffrey Edmond Cobb, Marcus Brackeen, Matthew Jude Sharp, John Mark O'Callaghan, Greg Alan Erickson, Grady Evan Boswell
  • Patent number: 6274385
    Abstract: The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: August 14, 2001
    Assignee: Abbott Laboratories
    Inventors: Jill Edie Hochlowski, Thomas J. Sowin, Daniel W. Norbeck, Anne-Laure Marie Grillot, Rolf E. Swenson
  • Patent number: 6172239
    Abstract: The invention relates to compounds of the formula The compounds have agreat affinity for the neurotensin receptors.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: January 9, 2001
    Assignee: Sanofi
    Inventors: Bernard Labeeuw, Danielle Gully, Francis JeanJean, Jean-Charles Molimard, Robert Boigegrain
  • Patent number: 6156891
    Abstract: Carboxylic acids of formula (1): ##STR1## wherein R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1 -C.sub.3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): ##STR2## The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): ##STR3## wherein R.sup.3 and Q are as defined above, with malonic acid derivatives of formula (6):R.sup.2 CH(COOH).sub.2wherein R.sup.2 is as defined above in the presence of a base.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: December 5, 2000
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Takashi Furukawa
  • Patent number: 6136852
    Abstract: The present invention relates to 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives represented by the general formula: ##STR1## [wherein Q represents a vinylene group or a group represented by the general formula:-A-(CH.sub.2).sub.m --(wherein A represents an oxygen atom or a methylene group; and m is an integer of from 1 to 6); R represents a hydrogen atom or a lower alkyl group; n is an integer of 1 or 2; the carbon atom marked with * represents a carbon atom in R configuration, S configuration or a mixture thereof; and the carbon atom marked with (S) represents a carbon atom in S configuration] and pharmaceutically acceptable salts thereof, which have a selective .beta..sub.2 -adrenergic receptor stimulating effect with relieved burdens on the heart such as tachycardia and are useful as an agent for the prevention of threatened abortion and premature labor, a bronchodilator and an agent for pain remission and promoting stone removal in urolithiasis.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: October 24, 2000
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Makio Kitazawa, Kosuke Okazaki, Tetsuro Tamai, Masaru Saito, Nobuyuki Tanaka, Hiroaki Kobayashi, Ken Kikuchi, Hideyuki Muranaka
  • Patent number: 6107517
    Abstract: Thyroid hormone analogues are disclosed. Methods of using such analogues and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: August 22, 2000
    Assignee: The Regents of the University of California
    Inventors: Thomas S. Scanlan, Hikari A.I. Yoshihara, Grazia Chiellini, Timothy J. Mitchison
  • Patent number: 6093799
    Abstract: A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH, an activated ester or the residue of a solid support having a plurality of amino functionalities; A is --O-- or --NH-- and Q is hydrogen or a protecting group for an amine or alcohol.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: July 25, 2000
    Assignee: Pharmacopeia, Inc.
    Inventors: Ge Li, Sian Louise Griffiths, Edward McDonald, Libo Xu
  • Patent number: 6066763
    Abstract: A process for preparing .alpha.-hydroxy acids by heating ammonium salts of .alpha.-hydroxy acids of general formula (I), removing the formed ammonia and water, adding water to the residue, and heating the obtained mixture, wherein R is hydrogen, C.sub.1 -C.sub.6 alkyl, alkyl(C.sub.1 -C.sub.6)thioalkyl (C.sub.1 -C.sub.6), phenyl or the like. This process is freed from the problem of disposal of by-products such as ammonium bisulfate and makes it possible to prepare a free .alpha.-hydroxy acid from an ammonium salt thereof economically and in a high yield.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: May 23, 2000
    Assignee: Nippon Soda Co., Ltd.
    Inventor: Koichi Hayakawa
  • Patent number: 6040462
    Abstract: Novel calix[4]arene dibenzo crown ethers useful to selectively extract cesium are represented by the formula: wherein R is a C.sub.1 -C.sub.10 normal alkyl, a phenyl or a methoxyphenyl, R' is hydrogen, p-tert-butyl or a C.sub.1 -C.sub.10 normal alkyl, R" is a C.sub.1 -C.sub.10 normal alkyl, and n is an integer of 0-2. The novel compound is prepared at high yields by introduction of benzene rings into the crown ether ring of calix[4]arene crown-6-ether. The calix[4]arene dibenzo crown ethers are superior in selective absorptivity for cesium ions by virtue of their 1,3-alternate conformational structure and thus, can be used as selective extractants able to separate cesium ions at a high efficiency.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: March 21, 2000
    Assignees: Korea Atomic Energy Research Institute, Korea Electric Power Corporation
    Inventors: Won Zin Oh, Kune Woo Lee, Wang Kyu Choi, Hyun Soo Park, Jong Seung Kim, Moon Hwan Cho, Jong Kook Kim
  • Patent number: 6008321
    Abstract: A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH, an activated ester or the residue of a solid support having a plurality of amino functionalities; A is --O-- or --NH-- and Q is hydrogen or a protecting group for an amine or alcohol.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: December 28, 1999
    Assignee: Pharmacopeia, Inc.
    Inventors: Ge Li, Sian Louise Griffiths, Edward McDonald, Libo Xu
  • Patent number: 5990342
    Abstract: A surfactant, an emusifier for emulsion polymerization, a dispersant for suspension polymerization and a modifier for modification of resin properties are disclosed, each of these agents being comprised of a novel compound having a dibasic carboxyl group. The compound is represented by Formula (1)[X--O--(R.sup.1 O).sub.m --OC--R.sup.2 --COO].sub.y M (1)where M is a hydrogen atom, a metal atom or a quaternary nitrogen-containing group, y is equal to the valence of M, R.sup.1 is at least one hydrocarbon group, R.sup.2 is a moiety of a dibasic acid or a moiety of its anhydride, m is 0 or an integer of 1 to 1,000, and X is a hydrocarbon group having at least one polymerizable double bond of carbon--ncarbon which may contain an oxygen atom and a fluorine atom.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: November 23, 1999
    Assignee: Asahi Denka Kogyo K.K.
    Inventors: Masahide Tsuzuki, Kaoru Komiya
  • Patent number: 5939584
    Abstract: Process for preparing solid, free-flowing water-soluble salts of aryloxy-C.sub.1 -C.sub.4 -alkanecarboxylic acids by reacting the aryloxy-C.sub.1 -C.sub.4 -alkanecarboxylic acids with a salt-forming base, the salt formation taking place in the melt in the presence or absence of an entraining agent suitable for the azeotropic removal of water or in solution in the presence of an entraining agent suitable for the azeotropic removal of water and, if appropriate, removing the entraining agent from the reaction mixture during the reaction or subsequently and then isolating the solid salts in a customary manner.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: August 17, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans Rupert Merkle, Karl Siegfried Brenner, Erich Fretschner, Michael Schonherr, Anne van Gastel
  • Patent number: 5883294
    Abstract: Selective thyroid hormone agonists are disclosed that are highly selective for the TR.beta. subtype with high binding affinity. Methods of using such agonists and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: March 16, 1999
    Assignee: The Regeants of the University of California
    Inventors: Thomas S. Scanlan, Grazia Chiellini, Hikari Yoshihara, James Apriletti, John D. Baxter, Ralff C. J. Ribeiro
  • Patent number: 5877334
    Abstract: A solid phase synthesis method and intermediates useful in the process are disclosed for the preparation of diamino diol and diamino alcohol inhibitors of HIV protease.
    Type: Grant
    Filed: July 23, 1996
    Date of Patent: March 2, 1999
    Assignee: Abbott Laboratories
    Inventor: Gary T. Wang
  • Patent number: 5869735
    Abstract: Process for the preparation of alkyl aryl ethers containing carboxyl groups which are suitable for the preparation of colour film couplers, or derivatives thereof, by reaction of aromatic alcohols with alkyl halides containing carboxyl groups or derivatives thereof and basic alkali metal or alkaline earth metal compounds, characterized in that the reaction is carried out in the melt of the aromatic alcohol.
    Type: Grant
    Filed: October 11, 1996
    Date of Patent: February 9, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Stefan Antons, Erich Hammerschmidt, Heinz Ulrich Blank, Helmut Fiege, Heinz-Gerd Hartges
  • Patent number: 5780624
    Abstract: A process for preparing oxime ethers of the general formula I ##STR1## where R.sup.1 is a C-organic radical,R.sup.2 is hydrogen, alkoxy, cyano, nitro, SOR.sup.4, SO.sub.2 R.sup.4, CO.sub.2 -alkyl, P(O)(OR.sup.4).sub.2 or a C-organic radical, andR.sup.3 and R.sup.4 are unsubstituted or substituted C.sub.1 -C.sub.6 -alkyl, entails converting an oxime of the general formula II ##STR2## where the substituents R.sup.1 and R.sup.2 have the abovementioned meanings, in the presence or absence of an organic diluent, with a base into the corresponding salt, and reacting the latter with a dialkyl carbonate of the general formula III ##STR3## where R.sup.3 has the abovementioned meanings.
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: July 14, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Wingert, Michael Keil
  • Patent number: 5767310
    Abstract: Phenoxyphenylacetic acids and derivatives of general structural formula (I) have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: June 16, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Scott W. Bagley, Theodore P. Broten, Prasun K. Chakravarty, Daljit S. Dhanoa, Kenneth J. Fitch, William J. Greenlee, Nancy Jo Kevin, Douglas J. Pettibone, Ralph A. Rivero, James R. Tata, Thomas F. Walsh, David L. Williams, Jr.
  • Patent number: 5766610
    Abstract: Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: June 16, 1998
    Assignee: Centre International De Recherches Dermatologiques Galderma
    Inventor: Jean-Michel Bernardon
  • Patent number: 5734077
    Abstract: New substituted 2,2-dimethyl-.omega.-phenoxyalkanoic acids and esters of formula: ##STR1## wherein: X, A, B, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and Z are as defined in the specification,The corresponding enantiomers and diastereoisomers, and the physiologically tolerable salts thereof with appropriate bases.The products of the invention may be used therapeutically.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: March 31, 1998
    Assignee: Adir ET Compagnie
    Inventors: Gilbert Regnier, Claude Guillonneau, Jean-Paul Vilaine, Florence Mahlberg, Christine Breugnot
  • Patent number: 5698711
    Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 16, 1997
    Assignee: Rhone-Poulenc Rorer Limited
    Inventor: Malcolm Norman Palfreyman
  • Patent number: 5679740
    Abstract: Mechanically stable, self-inverting water-in-oil polymer emulsions for use in industrial water treatment, waste water treatment, sludge conditioning, ore dressing, papermaking, secondary and tertiary oil recovery containing carboxylated ethoxylated phenols and alcohols are provided.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: October 21, 1997
    Assignee: Cytec Technology Corp.
    Inventor: Howard Ivan Heitner
  • Patent number: 5658944
    Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein Ar is a mono- or bicyclic aromatic group optionally containing one or two heteroatoms independently selected from nitrogen, oxygen and sulphur, said group being optionally substituted by one or more atoms or groups independently selected from halogen, nitro, amino, --NRR.sup.1 where R and R.sup.1 are independently selected from hydrogen, C.sub.1-8 alkyl and C.sub.1-8 alkanoyl, cyano, carboxyalkoxy, alkoxycarbonylalkoxy, C.sub.1-8 alkyl (including cycloalkyl and cycloalkylalkyl), C.sub.1-8 alkoxy (including cycloalkoxy and cycloalkylalkoxy), C.sub.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: August 19, 1997
    Assignee: The University of South Carolina
    Inventors: James Mood Chapman, Jr., Roy Lee Hawke, Karl Witold Franzmann, Kevin Julian O'Connor
  • Patent number: 5654476
    Abstract: A process for the preparation of 2,2-dimethyl-5-(2,5-xylyloxy)-valeric acid, which process comprises the reaction of 2,5-dimethylphenol with a compound of formula (II), ##STR1## wherein R is an alkyl, aryl, arylalkyl group and --X is a halogen atom, and the subsequent hydrolysis to compound (I), characterized in that the reaction of compound (II) with 2,5-dimethylphenol is carried out in the absence of solvents and in the presence of an ammonium or quaternary phosphonium salt.
    Type: Grant
    Filed: November 16, 1995
    Date of Patent: August 5, 1997
    Assignee: Recordati S.A. Chimical and Pharmaceutical Company
    Inventors: Gianfranco Piccoli, Antonio Tarquini, Giovanni Frare
  • Patent number: 5654469
    Abstract: Compounds of Formula I ##STR1## wherein the symbols are as defined in the specification.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: August 5, 1997
    Assignee: Allergan
    Inventors: Vidyasagar Vuligonda, Min Teng, Richard L. Beard, Alan T. Johnson, Yuan Lin, Roshantha A. Chandraratna
  • Patent number: 5654338
    Abstract: Optically active .alpha.-(hydroxyphenoxy)-alkanecarboxylic acids or derivatives thereof, for example D-2-(4-hydroxyphenoxy)propionic acid or lower alkyl ester thereof, are prepared by (a) saponifying an alkyl ester of an optically active .alpha.-halogeno-alkanecarboxylic acid, in an alcoholic solvent medium, by reacting same with an aqueous solution of an alkali metal hydroxide, thereby providing a solution of an alkali metal salt of an optically active .alpha.-halogeno-alkanecarboxylic acid, (b) next reacting the step (a) solution thus provided with a dihydroxybenzene or salt thereof, in the presence of an alkali metal hydroxide and in an alcoholic solvent medium, and thence (c) recovering the optically active .alpha.-(hydroxyphenoxy)-alkanecarboxylic acid or derivative thereof from the medium of reaction.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: August 5, 1997
    Assignee: Rhone-Poulenc Chimie
    Inventor: Pascal Metivier
  • Patent number: 5650533
    Abstract: The invention relates to 4-substituted isoxazole derivatives of formula I: ##STR1## wherein R, R.sup.1, R.sup.2, Q and n have the meaning defined in the description which possess valuable herbicidal properties.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 22, 1997
    Assignee: Rhone-Poulenc Agriculture Ltd.
    Inventors: David Alan Roberts, Susan Mary Cramp, Derek Ian Wallis, Jean-Paul Bulot
  • Patent number: 5646184
    Abstract: Disclosed is a preparation for external application to the skin characterized by containing at least one of benzoic acid derivatives represented by formula (I) or pharmacologically acceptable salts thereof as an active ingredient, the preparation having sufficient sebaceous secretion inhibitory activity with no substantial side effect and high safety for human body. ##STR1## wherein R.sup.1 represents --OH, --OR.sup.3 or --NHR.sup.3 ; R.sup.2 represents a hydrogen atom, a lower alkyl group or a lower acyl group; R represents --O--R.sup.4 or ##STR2## R.sup.3 represents an alkyl group, an alkenyl group or a hydroxyalkyl group; R.sup.4 represents a straight-chain or branched, saturated or mono-unsaturated alkyl group or cycloalkylalkyl group having from 4 to 10 carbon atoms; X represents --O-- or --NH--; and n represents 1 or 2.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: July 8, 1997
    Assignee: Kao Corporation
    Inventors: Akira Sakaguchi, Takashi Kitahara, Keiko Koizumi, Noriko Sato, Kimihiko Hori, Hiroyuki Shinta
  • Patent number: 5635608
    Abstract: The invention relates to caged compounds for the study of biological processes, where the caged compound has a photoremoveable .alpha.-carboxy-substituted o-nitrobenzyl group. Covalent attachment of the substituted o-nitrobenzyl to a parent compound yields a caged compound with biological and/or physical properties that are significantly altered from the original properties of the parent compound. Illumination of the caged compounds to cleave the photoremoveable group yields the parent compound with its original properties restored.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: June 3, 1997
    Assignee: Molecular Probes, Inc.
    Inventors: Richard P. Haugland, Kyle R. Gee
  • Patent number: 5608084
    Abstract: Lactones of formula ##STR1## and their pharmacologically acceptable salts endowed with antioxiding and hypolipidaemic properties and that show the capability to prevent and/or to delay the oxidative modification of the lipoproteins by competing with the chain of propagation of the lipidic peroxidation by means of an effective scavenging of the peroxylic radicals. The compounds object of the present invention are useful in the treatment of the atherosclerosis and of many correlated vascular pathologies, like ischaemic cardiopathies (angina pectoris and myocardial infarction), cerebral thrombosis and peripheral arteriopathies, because the high plasma levels of lipids and the oxidative modifications of the low density lipoproteins (LDL) represent crucial events in the pathogenesis of the atherosclerosis.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: March 4, 1997
    Assignee: Alfa Wassermann S.p.A.
    Inventors: Goffredo Rosini, Claudia Baldazzi, Eleonora Romagnoli, Stefano Saguatti, Silvano Piani
  • Patent number: 5563129
    Abstract: There are disclosed novel hydroquinone derivatives of the formula: ##STR1## The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: October 8, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hirotomo Masuya, Masayoshi Yamaoka
  • Patent number: 5556864
    Abstract: Compounds of formula (I): ##STR1## [wherein: R.sup.1 is aryl; R.sup.2 is hydrogen, alkyl, alkoxy, halogen or cyano; R.sup.3 is a group of formula --B--NR.sup.4 R.sup.5, where R.sup.4 and R.sup.5 are independently hydrogen, alkyl or substituted alkyl or R.sup.4 and R.sup.5, together with the nitrogen to which they are attached, form a heterocycle, and B is alkylene or a group of formula --CH.sub.2 CH(OR.sup.6)CH.sub.2 --, where R.sup.6 is hydrogen, alkanoyl, substituted alkanoyl or arylcarbonyl, or a group of formula --D--R.sup.7, where D is a single bond or alkylene and R.sup.7 is a heterocycle; and A is alkylene; and pharmaceutically acceptable salts and esters thereof] are useful for the treatment and prevention of circulatory diseases and psychosis.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: September 17, 1996
    Assignee: Sankyo Company, Limited
    Inventors: Koichi Fujimoto, Naoki Tanaka, Fumitoshi Asai, Tomiyoshi Ito, Hiroyuki Koike
  • Patent number: 5530145
    Abstract: Novel anticholesteremic compounds capable of reducing blood cholesterol levels. Also included in this invention are (i) intermediates from which the abovementioned anticholesteremic compounds can be prepared, and (ii) methods for preparing both the intermediates and the anticholesteremic compounds.
    Type: Grant
    Filed: December 6, 1994
    Date of Patent: June 25, 1996
    Assignee: Syn-Tech Chem & Pharm Co., Ltd.
    Inventors: Hui-Po Wang, On Lee, Chin-Tsai Fan
  • Patent number: 5523457
    Abstract: This invention relates to a retinoid mpound of formula I ##STR1## in which Y is --CO--NH--, --CR.sup.2 .dbd.CR.sup.3 --, --CO--O--, --O--CO--, --C(.dbd.S)--NH--, --C.tbd.C--, --O--CH.sub.2 --, --CH.sub.2 --O--, or --CH.sub.2 --CH.sub.2 --;A is --(CH.sub.2).sub.t -- or a bond;Q is phenyl optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen, or --CO.sub.2 R.sup.4 ;R.sup.1 is --CO.sub.2 Z, --CONHR.sup.5, C.sub.1-6 alkyl, --CH.sub.2 OH, or --CHO;R.sup.2, R.sup.3, R.sup.4, R.sup.5, and Z are independently hydrogen or C.sub.1-6 alkyl;t is one to six.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 4, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Starrett, Jr., Muzammil M. Mansuri, David R. Tortolani
  • Patent number: 5512595
    Abstract: New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and Z are as defined in the description.Those compounds and their physiologically tolerable salts can be used therapeutically.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: April 30, 1996
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnier, Claude Guillonneau, Jean-Paul Vilaine, Albert Lenaers, Christine Breugnot
  • Patent number: 5489447
    Abstract: A description is given of carrier-bound compounds of the formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 independently of one another are hydrogen, halogen, nitro, cyano, CF.sub.3, C.sub.1 -C.sub.15 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.2 -C.sub.15 alkenyl, C.sub.1 -C.sub.12 haloalkyl, C.sub.1 -C.sub.12 alkoxy, C.sub.1 -C.sub.12 alkylthio, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 aryloxy, C.sub.7 -C.sub.12 arylalkyl, --CO.sub.2 R.sub.6, --COR.sub.6 or ##STR2## in which at least one of the radicals R.sub.1 to R.sub.5 is hydrogen, halogen or C.sub.1 -C.sub.15 alkyl, and, in addition, the radicals R.sub.1 and R.sub.2, R.sub.2 and R.sub.3, R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 together with the carbon atoms to which they are attached form a benzo or cyclohexenyl ring,R.sub.6 is C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkyl which is interrupted by oxygen, sulfur or >N--R.sub.9 ; or is C.sub.7 -C.sub.12 arylalkyl,R.sub.7 and R.sub.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: February 6, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas Kramer, Adalbert Braig