Abstract: The present invention relates to methods for the synthesis of chiral non-racemic products, e.g., enantiomerically-enriched hemiesters, from prochiral starting materials, e.g., meso anhydrides. The present invention also relates to catalysts for the aforementioned methods, and methods for synthesizing these catalysts.
Abstract: The present invention relates to methods for the synthesis of chiral non-racemic products, e.g., enantiomerically-enriched hemiesters, from prochiral and meso starting materials, e.g., prochiral and meso cyclic anhydrides. The present invention also relates to catalysts for the aforementioned methods, and methods for synthesizing these catalysts.
Abstract: A process is described for recycling catalysts in the reaction for the oxidation of alcohols and/or ketones to carboxylic acids and more particularly the oxidation of cyclic alcohols and/or cyclic ketones to dicarboxylic acids, such as the oxidation of cyclohexanol and/or cyclohexanone to adipic acid. This process involves treating the solution comprising the oxidation catalyst, before it is recycled, with an ion-exchange resin which makes it possible to selectively separate the iron from the other metal elements, in particular from copper and from vanadium.
Abstract: A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.
Type:
Grant
Filed:
November 10, 2004
Date of Patent:
April 11, 2006
Assignee:
Wyeth
Inventors:
Michael W. Winkley, Karen W. Sutherland
Abstract: A carboxylic acid is produced by oxidative cleavage of a cycloalkane with oxygen and performs a reaction in the presence of a catalyst including an imide compound and a metallic compound, the imide compound having a cyclic imide skeleton represented by the following Formula (I): wherein X is an oxygen atom or an —OR group, and wherein R is a hydrogen atom or a hydroxyl-protecting group, under conditions of a reaction temperature of 80° C. or higher and a concentration of the cycloalkane of 21% by weight or more.
Abstract: A polyamide that includes the reaction product of dimer acid (e.g. a dimer acid including at least 98% by weight dimer), caprolactam, hexamethylene diamine, sebacic acid, and optionally, chain terminating agent.
Type:
Grant
Filed:
June 14, 2002
Date of Patent:
February 21, 2006
Assignee:
H.B. Fuller Licensing & Financing Inc.
Inventors:
Steven L. Scholl, Sharf U. Ahmed, Andualem W. Emiru
Abstract: A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A mixture of liquid organic acids, including butyric acid, is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product. The addition of butyric acid results in a product which has an improved effect on animal growth over the animal feed additive without the addition of butyric acid.
Type:
Grant
Filed:
January 15, 2003
Date of Patent:
February 21, 2006
Assignee:
Kemin Industires, Inc.
Inventors:
Stefaan Van Dyck, Clifford Adams, Andre Meeuwsen, Leen van Campenhout
Abstract: A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A liquid organic acid is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product.
Abstract: The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1 to R11 are as defined herein.
Type:
Grant
Filed:
July 12, 2001
Date of Patent:
January 3, 2006
Assignee:
Biotie Therapies Corp.
Inventors:
David John Smith, Ferenc Fülöp, Marjo Pihlavisto, László Lázár, Sakari Alaranta, Petri Vainio, Zsolt Szakonyi
Abstract: Process for drying moist, solid adipic acid using at least two drying stages in which moist solid adipic acid is progressively dried by contacting it in at least two successive stages with a nonreactive gas, the temperature of the first stage being lower than the temperature in any of the subsequent stages.
Abstract: This invention pertains to novel methods for the synthesis of certain nitrogen mustard prodrugs, such as N-{4-[N,N-bis(2-haloethylamino)-phenoxycarbonyl}-L-glutamic acid: wherein: X2 is a halo group, and is —F, —Cl, —Br, or —I; n is an integer from 0 to 4; and, each RA is an aryl substituent. The methods comprise, at least, the steps of: glutamate conjugation (GC); silyloxy deprotection (SD); and, sulfonic esterification (SU). Certain preferred methods comprise the steps of: amine substitution (AS); silyloxy protection (SP); phenolic deprotection (PD); activation (AC); glutamate conjugation (GC); silyloxy deprotection (SD); sulfonic estenfication (SU); halogenation (HL); glutamate deprotection (GD); and glutamic acid protection (GP).
Type:
Grant
Filed:
January 24, 2002
Date of Patent:
July 12, 2005
Assignee:
Cancer Research Technology Limited
Inventors:
Caroline Joy Springer, Dan Niculescu-Duvaz
Abstract: A process for preparing butanetetracarboxylic acid derivatives as product of value I by coupled electrosynthesis which comprises cathodically reducing a compound selected from the group consisting of maleic esters, maleic ester derivatives, fumaric esters and fumaric ester derivatives where at least one hydrogen atom in positions 2 and 3 may be replaced by inert groups and obtaining a product of value II at the node.
Type:
Grant
Filed:
November 16, 2001
Date of Patent:
June 21, 2005
Assignee:
BASF Aktiengesellschaft
Inventors:
Hermann Pütter, Andreas Weiper-Idelmann
Abstract: The present invention is to provide a technology to establish a new cycle-based organic chemical industry, which may be called a polymer cascade (polymer reflux industry) wherein the polymer substances shall not remain the final products, but still give birth to synthetic materials as raw materials for chemical industry and produce useful organic compounds.
Abstract: The present invention relates to a process for the manufacture of adipic acid crystals and to the crystals obtained. It relates more specifically to a process for the treatment of the adipic acid crystals obtained at the end of crystallization in order to obtain crystals which can be stored with minimum possibility of caking. This process consists of a maturing stage in order to partially remove the water present in the said crystals.
Abstract: A process for recovering carboxylic acids from an aqueous mixture such as a fermentation broth using a solvent containing at least one olefin without the need for first removing the spent microorganism cells is provided. A co-solvent which increases the partition coefficient of the solvent relative to the carboxylic acid may optionally be included. The resulting carboxylic acid is hydrogenated to produce a saturated carboxylic acid.
Abstract: Compounds having the formula:
are disclosed. M1 and M2 are the same or different and are transition metal atoms or ions; Z2 and Z3, independently, are the atoms necessary to complete a 3-12 membered heterocyclic ring; Z1 is an alkylene or arylene group; Q1 and Q2 are the same or different and are electron withdrawing groups; L1 and L3, taken together, represent —O—CR13—O—; L2 and L4, taken together, represent —O—CR14—O—; and R13 and R14 are the same or different and are selected from the group consisting of alkyl groups and aryl groups or R13 and R14 represent alkylene or arylene groups that are directly or indirectly bonded to one another. Methods for making such compounds are also disclosed, as are intermediates which can be used in their preparation. Also disclosed are methods for carrying out C—H insertion reactions using bis-transition metal catalysts, such as the above compounds.
Type:
Grant
Filed:
March 30, 2002
Date of Patent:
July 13, 2004
Assignee:
Research Foundation of State University of New York
Abstract: Powder comprising particles of a curing agent selected from the group consisting of azelaic acid, sebacic acid, undecanedioic acid, dodecanedioic acid, brassylic acid and the anhydrides of said acids.
Abstract: The present invention is directed to a process for the synthesis of monoalkylated C—H acidic methylene group-containing compounds, such as malonic esters, and malonic ester nitriles.
Abstract: The present invention relates to novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Type:
Grant
Filed:
October 11, 2001
Date of Patent:
March 9, 2004
Assignee:
Esperion Therapeutics, Inc.
Inventors:
Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
Abstract: Powder comprising substantially spherical particles of at least one compound selected from the group consisting of azelaic acid, sebacic acid, undecanedioic acid, dodecanedioic acid, brassylic acid, and the anhydrides of said acids, said at least one compound being distributed substantially uniformly throughout the entirety of each of said particles, said particles having a particle size distribution as follows:
d90
-
d10
d50
<
1.90
wherein:
d50 is a particle diameter at which 50% of the particles have diameters which are greater or smaller than the d50 value;
d90 is a particle diameter at which 90% of the particles have diameters which are smaller than the d90 value;
d10 is the particle diameter at which 10% of the particles have diameters which are smaller than the d10 value; and
d50 is 8 to 30 micrometers.
Abstract: A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.
Type:
Grant
Filed:
February 11, 2002
Date of Patent:
January 6, 2004
Assignee:
Wyeth
Inventors:
Anthony F. Hadfield, Syed M. Shah, Michael W. Winkley, Karen W. Sutherland, James A. Provost, Aeri Park, Rex A. Shipplett, Brenton W. Russell, Beat T. Weber
Abstract: Processes for producing citraconic anhydride and citraconic acid using porous materials with specific surface acidities and surface areas are described. The preferred catalyst is a porous gamma alumina. Itaconic acid is produced from citraconic acid. Itaconic acid is an intermediate to a variety of compounds including polymers.
Type:
Grant
Filed:
August 23, 2002
Date of Patent:
December 16, 2003
Assignee:
Board of Trustees of Michigan State University
Inventors:
Dennis J. Miller, Dushyant Shekhawat, Kirthivasan Nagarajan, James E. Jackson
Abstract: A process for recovering carboxylic acids from an aqueous mixture such as a fermentation broth using a solvent containing at least one olefin without the need for first removing the spent microorganism cells is provided. A co-solvent which increases the partition coefficient of the solvent relative to the carboxylic acid may optionally be included.
Abstract: Metformin salts of lipophilic acids, their pharmaceutical formulations, and methods of administrating the metformin salts for the treatment of hyperglycemia.
Type:
Application
Filed:
February 14, 2003
Publication date:
November 27, 2003
Applicant:
Sonus Pharmaceuticals, Inc.
Inventors:
Manjari Lal, Nagesh Palepu, Dean Kessler
Abstract: A method of making a cesium salt is described and involves reacting a cesium sulfate containing solution with lime to form 1) a solution containing at least cesium hydroxide and 2) a residue comprising calcium sulfate. The method further involves removing the residue from the solution and converting the cesium hydroxide that is present in the solution to at least one type of cesium salt. The present invention further relates to uses of the cesium salt as well as methods of making cesium hydroxide using lime. Also, methods of making alkali metal salts and alkali metal hydroxides are also described.
Abstract: Compounds of the formula R2.[(AO)n.R3]m, where R2 is a residue of a group having at least m active hydrogen atoms derived from hydroxyl and/or amino and/or amido groups, AO is alkyleneoxy, n is 2 to 200; R3 includes residue(s) of alkenyl succinic acids and optionally other acids, and m is 2 to 10, but when m is 2 there are other restrictions in the definitions, are disclosed as useful thickeners and/or dispersants in aqueous systems. The use of such materials as thickeners is also disclosed.
Type:
Application
Filed:
December 10, 2002
Publication date:
August 14, 2003
Applicant:
Imperial Chemical Industries PLC
Inventors:
Neil Michael Carpenter, Steven John Anderson, Richard Robert Tenore, Peter Glynn Hibbert
Abstract: Phosphinato-substituted propane- and butanepolycarboxylic acids and derivatives thereof are useful as crosslinking agents for cellulosic materials to render them wrinkle resistant and/or iron free in a durable press process.
Abstract: This invention relates to novel substituted succinic acid metallo-&bgr;-lactamase inhibitors which are useful potentiators of &bgr;-lactam antibiotics.
Type:
Application
Filed:
March 15, 2002
Publication date:
April 24, 2003
Inventors:
James M. Balkovec, Mark L. Greenlee, Steven H. Olson, Gregory P. Rouen
Abstract: The invention discloses a method for purifying adipic acid by crystallization or recrystallization in at least one carbolyxic acid. More precisely, it discloses an improvement in adipic acid crystallization or recrystallization, characterised in that the said crystallization or recrystallization is effected in at least one carboxylic acid with a melting point below 20° C. The presence of carbon monoxide during crystallization or recrystallization can have a favourable effect on the adipic acid purity, in particular by reducing the content of metal catalyst traces of the adipic acid. The adipic acid purity can also be improved when the crystallization or recrystallization is effected in presence of a strong proton acid.
Type:
Grant
Filed:
December 4, 1998
Date of Patent:
March 25, 2003
Assignee:
Rhodia Fiber & Resin Intermediates
Inventors:
Eric B. Henriet, Philippe Leconte, Carl Patois, Robert Perron
Abstract: Dicarboxylic acid crystals are prepared from a solution containing at least one organic dicarboxylic acid in a process in which at least one anionic polyelectrolyte having a molecular weight of at least 2000 is added to the solution before or during the crystallization.
Type:
Grant
Filed:
October 27, 1999
Date of Patent:
March 18, 2003
Assignee:
BASF Aktiengesellschaft
Inventors:
Matthias Rauls, Dieter Baumann, Hermann Wistuba, Bernhard Otto
Abstract: A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.
Type:
Application
Filed:
February 11, 2002
Publication date:
March 6, 2003
Applicant:
American Home Products Corporation
Inventors:
Anthony F. Hadfield, Syed M. Shah, Michael W. Winkley, Karen W. Sutherland, James A. Provost, Aeri Park, Rex A. Shipplett, Brenton W. Russell, Beat T. Weber
Abstract: A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A liquid organic acid is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product.
Abstract: A process for forming a mineral, food or pharmaceutical grade salt product is described. The process comprises completing all the process steps in a single reactor vessel resulting in high yield and purity in shortened processing times on the order of {fraction (1/10)} to ⅓ of the processing times required in prior processes.
Type:
Grant
Filed:
October 19, 2000
Date of Patent:
January 21, 2003
Assignee:
Nutrapure, Inc.
Inventors:
Dennis M. Hager, William E. Stern, Kim R. Nielsen
Abstract: Processes for producing citraconic anhydride and citraconic acid using porous materials with specific surface acidities and surface areas are described. The preferred catalyst is a porous gamma alumina. Itaconic acid is produced from citraconic acid. Itaconic acid is an intermediate to a variety of compounds including polymers.
Type:
Grant
Filed:
September 21, 2000
Date of Patent:
January 7, 2003
Assignee:
Board of Trustees of Michigan State University
Inventors:
Dennis J Miller, Dushyant Shekhawat, Kirthivasan Nagarajan, James E. Jackson
Abstract: Aliphatic tricarboxylic acids, as exemplified by 9-carboxy-1,18-octadecanedioic acid, may be prepared by the biotransformation of an olefinic monocarboxylic acid such as oleic acid to the corresponding olefinic dicarboxylic acid, preferably 1,18-octadec-9-enedioic acid, in the presence of a strain of yeast, such as a strain of Candida tropicalis, followed by the carboxylation of the olefinic dicarboxylic acid by reaction with carbon monoxide and water in the presence of a catalyst. The product tricarboxylic acids are useful as branching agents for polycarbonates.
Type:
Grant
Filed:
January 10, 2002
Date of Patent:
December 24, 2002
Assignee:
General Electric Company
Inventors:
David Paul Mobley, Mohan Mark Amaratunga, John Henry Lobos
Abstract: Aliphatic tricarboxylic acids, as exemplified by 9-carboxy-1,18-octadecanedioic acid, may be prepared by the biotransformation of an olefinic monocarboxylic acid such as oleic acid to the corresponding olefinic dicarboxylic acid, preferably 1,18-octadec-9-enedioic acid, in the presence of a strain of yeast, such as a strain of Candida tropicalis, followed by the carboxylation of the olefinic dicarboxylic acid by reaction with carbon monoxide and water in the presence of a catalyst. The product tricarboxylic acids are useful as branching agents for polycarbonates.
Type:
Application
Filed:
January 10, 2002
Publication date:
November 14, 2002
Inventors:
David Paul Mobley, Mohan Mark Amaratunga, John Henry Lobos
Abstract: A process for preparing a malonic acid monoester or &bgr;-ketoester from an epoxide includes the steps of reacting an epoxide with carbon monoxide and an alcohol in the presence of a catalytic amount of a cobalt compound and at least one promoter to produce a &bgr;-hydroxyester, separating the &bgr;-hydroxyester from the cobalt compound and the promoter, and oxidizing the &bgr;-hydroxyester to produce a malonic acid monoester or &bgr;-ketoester.
Type:
Grant
Filed:
June 20, 2001
Date of Patent:
October 15, 2002
Assignee:
Samsung Electronics Co., Ltd.
Inventors:
Byeong No Lee, In-Sun Jung, Eun Joo Jang
Abstract: A method is described for producing saturated dicarboxylic acids with a chain length of C6 to C21 or the corresponding diamidic dicarboxylic acids from fatty acid cleavage of unsaturated fatty acids or the bis-fatty acid diamides of these unsaturated fatty acids by oxidative ozonolysis and subsequent separation and purification of the dicarboxylic acids, whereby after oxidative ozonolysis, the reaction products are dissolved at a high temperature in a carboxylic acid or a mixture of several carboxylic acids with a medium chain length of C6 to C12 or esters of short-chain alcohols of these carboxylic acids as the recrystallization solvent.
Type:
Grant
Filed:
October 24, 2001
Date of Patent:
September 24, 2002
Assignee:
Dr. Frische GmbH
Inventors:
Rainer Frische, Katja Hegwein, Jürgen Volkheimer
Abstract: A process for preparing aliphatic C4-18 &agr;,&ohgr;-dicarboxylic acids by oxidation of C6-20 &agr;,&ohgr;-dienes with hydrogen peroxide or compounds which release hydrogen peroxide under the reaction conditions as is characterized in that the reaction is carried out in the presence of a transition metal catalyst of group VI and of a mixture containing at least one organic acid and one aprotic organic solvent. A specific temperature profile is maintained at different phases of the reaction, which increases yield and selectivity.
Type:
Grant
Filed:
May 11, 2000
Date of Patent:
August 20, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Michael Schelhaas, Helmut Greiving, Manfred Jautelat
Abstract: This invention relates to methods of controlling the oxidation of cyclohexane to adipic acid in the presence of a monobasic acid solvent, by extracting the catalyst from the reaction mixture, outside the reaction zone. Substantially all the unreacted cyclohexane, the majority of adipic acid, and preferably substantially all the monobasic acid solvent are removed from the reaction product. In the case that substantially all the monobasic acid solvent is removed, protic solvent, is added intermittently or continuously in the reaction mixture during the removal of the monobasic acid solvent, preferably by distillation, thus preventing solids precipitation. Dipolar aprotic solvent is then added in the presence of an adequate amount of the protic solvent (the total of dipolar aprotic solvent and the protic solvent constituting a novel combination solvent) to maintain a single liquid phase, followed by a step of extracting substantially all the catalyst in protic solvent.
Type:
Grant
Filed:
June 30, 1999
Date of Patent:
August 13, 2002
Assignee:
RPC Inc.
Inventors:
Douglas J. Dudgeon, David C. DeCoster, Mark W. Dassel, Eustathios Vassiliou, Ader M. Rostami
Abstract: This invention relates to methods of controlling the oxidation of cyclohexane to adipic acid in the presence of a monobasic acid solvent, by separating the catalyst from the reaction mixture, outside the reaction zone. Substantially all the unreacted cyclohexane, the majority of adipic acid, and substantially all the monobasic acid solvent are preferably removed. A protic solvent, may be added intermittently or continuously in the reaction mixture during the removal of the monobasic acid solvent, preferably by distillation, for preventing solids precipitation. A dipolar aprotic solvent is then added in the presence of an adequate amount of the protic solvent to maintain a single liquid phase, followed by a step of formation of two liquid phases, a solids-free protic liquid phase containing substantially all the catalyst, and a solids-free aprotic liquid phase containing at least the majority of ingredients of the reaction mixture.
Type:
Grant
Filed:
June 30, 1999
Date of Patent:
August 13, 2002
Assignee:
RPC Inc.
Inventors:
Ader M. Rostami, Douglas J. Dudgeon, David C. DeCoster, Mark W. Dassel, Eustathios Vassiliou
Abstract: A process for making an alkanedioic acid in which a mixture of a cycloalkene, a base and a solvent is contacted simultaneously with both oxygen and ozone at a temperature between 40 and 60 degrees Centigrade.
Abstract: The present invention relates to a polymer produced by polymerizing a vinyl aromatic monomer in the presence of a small amount of furfuryl (alkyl)acrylate.
Type:
Application
Filed:
July 25, 2001
Publication date:
July 25, 2002
Inventors:
Jose M. Rego, Ludo Aerts, Duane B Priddy, Mehmet Demirors
Abstract: This invention relates to methods of replacing water and cyclohexanone with acetic acid in an aqueous solution of catalyst, preferably a cobalt compound. Such an aqueous solution is produced by extracting catalyst with water from a cyclohexanone/water solution of reaction products made by the direct oxidation of cyclohexane to adipic acid. The replacement of both water and cyclohexanone are conducted in a solvent exchange column, wherein acetic acid dissolves the catalyst, while water vapors force the cyclohexanone into a condenser, followed by a decanter wherein two liquid phases may be formed and separated; an upper liquid phase containing a majority of cyclohexanone and a lower liquid phase containing a majority of water. The cyclohexanone may be removed in a pretreatment zone, wherein also part of the water may be removed, before the concentrated catalyst extract enters the solvent exchange column.
Type:
Grant
Filed:
April 19, 2000
Date of Patent:
July 9, 2002
Assignee:
RPC, Inc.
Inventors:
David C. DeCoster, Mark W. Dassel, Eustathios Vassiliou, Ader M. Rostami, Douglas J. Dudgeon
Abstract: A process for preparing malonic acid from the hydrolysis of cyanoacetic acid in the presence of aqueous hydrochloric acid, the process conditions being such that they allow high yields in malonic acid product. The product of said acid hydrolysis is a mixture of malonic acid and ammonium chloride by-product; the mixture is concentrated, the ammonium chloride by-product is separated by dissolution with an oxygen solvent and isolated. Alternatively, said concentrated mixture is dissolved with a primary or secondary esterifying alcohol in C1-C10, the resulting mixture being esterified, while the ester product is purified by distillation under reduced pressure, the molar yields and purity of the ester product being high.
Type:
Grant
Filed:
January 14, 2000
Date of Patent:
May 28, 2002
Assignee:
Trikem S.A.
Inventors:
Otavio Vianna Carvalho, Ronaldo Mendonca Mansur, Sandro da Silva Aguiar, Jane Hitoni Fujiyama, Antonio Luiz Ribeiro de Castro
Abstract: The invention discloses pentenoic acid hydroxycarbonylation into adipic acid. More particularly, it concerns one pentenoic acid hydroxycarbonylation method involving reaction water and carbon monoxide, in the presence of a catalyst comprising at least rhodium and/or iridium and an iodinated or brominated catalytic promoter. In the method, the catalyst is derived at least in part from a previous pentenoic acid hydroxycarbonylation operation. The reaction is effected in the presence of an amount of branched carboxylic diacids having 6 carbon atoms not exceeding 200 grams per kilogram reaction mixture.
Type:
Grant
Filed:
March 17, 1999
Date of Patent:
April 16, 2002
Assignee:
Rhodia Fiber & Resin Intermediates
Inventors:
Jacques Brivet, Eric B. Henriet, Carl Patois, Robert Perron
Abstract: A method is described for producing saturated dicarboxylic acids with a chain length of C6 to C21 or the corresponding diamidic dicarboxylic acids from fatty acid cleavage of unsaturated fatty acids or the bis-fatty acid diamides of these unsaturated fatty acids by oxidative ozonolysis and subsequent separation and purification of the dicarboxylic acids, whereby after oxidative ozonolysis, the reaction products are dissolved at a high temperature in a carboxylic acid or a mixture of several carboxylic acids with a medium chain length of C6 to C12 or esters of short-chain alcohols of these carboxylic acids as the recrystallization solvent.
Type:
Grant
Filed:
August 4, 2000
Date of Patent:
March 26, 2002
Assignee:
Frische GmbH
Inventors:
Rainer Frische, Katja Hegwein, Jürgen Volkheimer
Abstract: The present invention provides: an acrylic acid-maleic acid copolymer (or its salt) which is excellent in performances, such as Mg2+ scavengeability, clay dispersibility in the presence of Mg2+, inhibitability upon Mg(OH)2 scale, and inhibitability upon CaCO3 scale; and a production process for such a copolymer (or its salt). The present invention further provides a production process for an aqueous maleic salt solution with a low impurity content which has the advantage of easily giving the above copolymer (or its salt). The present invention still further provides uses of the above copolymer (or its salt) having the above excellent properties.
Abstract: Malonic esters of the general formula
where R is C1-10-alkyl, C3-10-alkenyl or aryl-C1-4-alkyl, are prepared by reacting an alkali metal salt of malonic acid with a halide of the general formula R—X (II), where R is as defined above and X is chlorine, bromine or iodine, in the presence of water and a phase-transfer catalyst.
Abstract: Osmium-catalyzed aminohydroxylation reactions are accelerated and expanded in scope by the use of olefinic substrates having ionic groups, either anionic or cationic. The use of ionic groups on olefinic substrates also extends the aminohydroxylatable positions of unsaturations to include &agr;,&bgr;, &bgr;,&ggr;, and &ggr;,&dgr; positions, with respect to such ionic groups. A mechanism for the disclosed acceleration and extension is provided.