Two Carboxamido Carbonyls Having No Carboxamido Nitrogen Between The Carbonyls Patents (Class 564/160)
  • Patent number: 8987524
    Abstract: A process for the manufacture of Sevoflurane CF3—CH(OCH2F)—CF3 which comprises (a) manufacturing a substituted malonic acid derivative of formula (I): R1OOC—CH(OCH2X)—COOR2 or of formula (II): R3HNOC—CH(OCH2X)—CONHR4, wherein X is OH or a leaving group which can be substituted by nucleophilic substitution and wherein R1, R2 R3, R4, equal to or different from each other, are independently selected from the group consisting of H, an alkyl group having from 1 to 10 carbon atoms which is optionally substituted by at least one halogen atom, an aralkyl group, and an aryl group; and (b) further reacting said malonic acid derivative as intermediate for the manufacture of Sevoflurane CF3—CH(OCH2F)—CF3.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: March 24, 2015
    Assignee: Solvay Fluor GmbH
    Inventor: Max Josef Braun
  • Patent number: 8975441
    Abstract: The present invention generally relates to a process for preparing 2,2-dibromomalonamide from 2,2-dibromo-3-cyanoacetamide.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: March 10, 2015
    Assignee: Dow Global Technologies LLC
    Inventors: Charles D. Gartner, Dawn Carsten
  • Publication number: 20140346089
    Abstract: The invention relates to a class of novel surfactants that have utility in the recovery and/or extraction of oil.
    Type: Application
    Filed: April 22, 2014
    Publication date: November 27, 2014
    Inventors: David S. Soane, Rosa Casado Portilla, John H. Dise, Robert P. Mahoney
  • Publication number: 20140309174
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: November 12, 2013
    Publication date: October 16, 2014
    Applicant: Eisai Co., Ltd
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Patent number: 8841484
    Abstract: Disclosed are certain partially fluorinated amide compounds and composite materials containing the compounds. Also disclosed are methods for making the composite materials.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: September 23, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Anilkumar Raghavanpillai, Stefan Reinartz
  • Patent number: 8835502
    Abstract: The invention provides methods of treating Friedreich's ataxia using histone deacetylase inhibitors.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: September 16, 2014
    Assignee: The Scripps Research Institute
    Inventors: Joel M. Gottesfeld, Kai Jenssen, David M. Herman, Ryan Burnett, C. James Chou
  • Patent number: 8785691
    Abstract: The novel lipophilic metal extractants of the class dialkyldiaza-tetraalkyloctanediamide (DADA) useful to selectively separate trivalent americium (sup. 241 Am) from trivalent lanthanides are represented by the formula 1: Wherein R is a C1 to C5 normal alkyl and R? is a C4 to C8 normal and branched alkyl group. The compounds are synthesized at high yield and purity by the reaction of corresponding N,N?-dialkylethylenediamine and N,N-dialkyl-2-chloroacetamide. The separation is achieved by utilizing the soft-soft interaction between the trivalent actinides and ‘N’ atoms of the extractant. Both soft donor “n” and hard donor ‘O’ sites are incorporated in the molecule for better extraction of trivalent actinides over trivalent lanthanides. Thus, this molecule can be used as selective extractant to separate trivalent actinides from trivalent lanthanides.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: July 22, 2014
    Assignee: Secretary, Department of Atomic Energy
    Inventors: Joti Nath Sharma, Ritesh Ruhela, Smitha Manohar, Piaray Kishen Wattal, Ashok Kumar Suri
  • Publication number: 20140127429
    Abstract: A method of forming a coloured substrate, comprising applying to or incorporating within the substrate a diacetylene compound, and exposing the substrate to (i) a first, activating stimulus that converts the diacetylene compound from an unreactive to a reactive form, and (ii) a second stimulus that causes the reactive form of the diacetylene compound to polymerize and form the coloured substrate, wherein the diacetylene compound reverts to its unreactive form on removal of the activating stimulus and is of formula I: Y—C?C—C?C—(CH2)n-T-Q-Z (I) wherein: n=an odd integer; T=CO, CS or a bond; Q=NH, S, O, OCONH, NHCONH, NH—CHE-CONH, NHCOO or NHCSNH wherein E is H or a C1-20 alkyl group; Z=H or a hydrocarbon group containing 1 to 20 carbon atoms; Y=H or any group comprising at least one carbon atom.
    Type: Application
    Filed: February 24, 2012
    Publication date: May 8, 2014
    Applicant: DATALASE LTD.
    Inventors: Anthony N. Jarvis, Christopher A. Wyres, Benjamin Mulchin, Adam O'Rourke
  • Publication number: 20140081045
    Abstract: Disclosed are metal plating compositions and methods. The metal plating compositions provide good leveling performance and throwing power.
    Type: Application
    Filed: September 16, 2012
    Publication date: March 20, 2014
    Applicant: Rohm and Haas Electronic Materials LLC
    Inventors: Erik Reddington, Gonzalo Urrutia Desmaison, Zukra I. Niazimbetova, Donald E. Cleary, Mark Lefebvre
  • Patent number: 8664405
    Abstract: The object is to provide a stable SM-108 derivative, which is effective as a carcinostatic agent, particularly an SM-108 derivative having good storage stability. An SM-108 compound having good storage stability can be produced by producing an organic sulfonic acid salt compound of SM-108. Further, a crystalline SM-108 compound containing a trace amount of an organic carboxylic acid can be produced by using an aqueous solution of the organic sulfonic acid salt of SM-108, and by adding an alkali metal salt of an organic carboxylic acid to the aqueous solution to neutralize the aqueous solution and then causing the crystal precipitation in the solution.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: March 4, 2014
    Assignee: Fujifilm Corporation
    Inventors: Nobuo Kato, Yusuke Higuchi, Chihiro Kondo, Makoto Sunagawa
  • Publication number: 20140057816
    Abstract: The invention relates to a class of novel surfactants that have utility in the recovery and/or extraction of oil.
    Type: Application
    Filed: November 5, 2012
    Publication date: February 27, 2014
    Applicant: Soane Energy, LLC
    Inventors: David S. Soane, Rosa Casado Portilla, John H. Dise, Robert P. Mahoney
  • Publication number: 20130333840
    Abstract: This invention relates to a polyether-amido-amine corn-pound, obtainable by a two-step reaction of a poly-etheramine with an alkyl acrylate and a polyalkyle-neimine, whereas the polyetheramine and the polyalkyleneimine have at least one primary or secondary amine group, in which the first step comprises the reaction of the polyetheramine with the alkyl acrylate and the second step comprises the reaction of the polyalkyleneimine with the product of the first step. The invention also relates to a method for synthesising a polyether-amido-amine compound by a two-step-reaction. Another object of this invention is a curable composition containing at least one polyether-amido-amine-compound of this invention and a method for coating the surface of a substrate or for binding at least two substrates together using such a curable composition.
    Type: Application
    Filed: February 3, 2012
    Publication date: December 19, 2013
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Frans A. Audenaert, Martin A. Hutchinson, Ian Robinson
  • Publication number: 20130306098
    Abstract: The present invention relates to bleaching composition for keratin fibres, especially human hair, comprising at least one compound with bleaching and/or highlighting effect and a lipidic compound.
    Type: Application
    Filed: December 23, 2011
    Publication date: November 21, 2013
    Applicant: KAO GERMANY GMBH
    Inventors: Jonathan Wood, Mustafa Grit
  • Patent number: 8580712
    Abstract: Novel bis(dialkylamide) compounds having the formula: R2R3NOC—R1a—CONR4R5 are particularly useful solvents, for example in plant-protection formulations.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: November 12, 2013
    Assignee: Rhodia Operations
    Inventors: Jean-Manuel Mas, Valerio Bramati, Massimo Guglieri, Wagner Celio Ferraz Lourenco
  • Publication number: 20130225409
    Abstract: Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amines, wherein the fatty amine is made by reducing the amide reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and a secondary amine, are disclosed. Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amidoamines, wherein the amidoamine is made by reacting of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and an aminoalkyl-substituted tertiary amine, are also disclosed. The quaternized compositions are advantageously sulfonated or sulfated. In one aspect, the ester derivative of the C10-C17 monoun-saturated acid or octadecene-1,18-dioic acid is a lower alkyl ester. In other aspects, the ester derivative is a modified triglyceride made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin.
    Type: Application
    Filed: October 25, 2011
    Publication date: August 29, 2013
    Applicant: Stepan Company
    Inventors: Dave R. Allen, Marcos Alonso, Randal J. Bernhardt, Aaron Brown, Sangeeta Ganguly-Mink, Andrew D. Malec, Teresa Manuel, Ronald A. Masters, Lawrence A. Munie, Dennis S. Murphy, Patti Skelton, Brian Sook, Michael R. Terry, Jeremy Aaron Weitgenant, Laura Lee Whitlock, Michael Wiester, Patrick Shane Wolfe
  • Patent number: 8273398
    Abstract: The present invention concerns geranylamine derivates of oxalic acid, use of the same as flavorings and certain mixtures, compositions, preparations and semi-finished goods containing one or more such compounds.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: September 25, 2012
    Assignee: Symrise AG
    Inventors: Michael Backes, Jan Looft
  • Publication number: 20120172626
    Abstract: The novel lipophilic metal extractants of the class dialkyldiaza-tetraalkyloctanediamide (DADA) useful to selectively separate trivalent americium (sup. 241 Am) from trivalent lanthanides are represented by the formula 1: Wherein R is a C1 to C5 normal alkyl and R? is a C4 to C8 normal and branched alkyl group. The compounds are synthesized at high yield and purity by the reaction of corresponding N,N?-dialkylethylenediamine and N,N-dialkyl-2-chloroacetamide. The separation is achieved by utilizing the soft-soft interaction between the trivalent actinides and ‘N’ atoms of the extractant. Both soft donor “n” and hard donor ‘O’ sites are incorporated in the molecule for better extraction of trivalent actinides over trivalent lanthanides. Thus, this molecule can be used as selective extractant to separate trivalent actinides from trivalent lanthanides.
    Type: Application
    Filed: September 11, 2009
    Publication date: July 5, 2012
    Applicant: Secretary ,Department of Atomic Energy
    Inventors: Joti Nath Sharma, Ritesh Ruhela, Smitha Manohar, Piaray Kishen Wattal, Ashok Kumar Suri
  • Publication number: 20120157708
    Abstract: A process for the manufacture of Sevoflurane CF3—CH(OCH2F)—CF3 which comprises (a) manufacturing a substituted malonic acid derivative of formula (I): R1OOC—CH(OCH2X)—COOR2 or of formula (II): R3HNOC—CH(OCH2X)—CONHR4, wherein X is OH or a leaving group which can be substituted by nucleophilic substitution and wherein R1, R2 R3, R4, equal to or different from each other, are independently selected from the group consisting of H, an alkyl group having from 1 to 10 carbon atoms which is optionally substituted by at least one halogen atom, an aralkyl group, and an aryl group; and (b) further reacting said malonic acid derivative as intermediate for the manufacture of Sevoflurane CF3—CH(OCH2F)—CF3.
    Type: Application
    Filed: August 10, 2010
    Publication date: June 21, 2012
    Applicant: SOLVAY FLUOR GMBH
    Inventor: Max Josef Braun
  • Publication number: 20120136073
    Abstract: There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 31, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Zhiwei Yang, Parul Angrish, Xavier de Mollerat du Jeu, Kristin Wiederholt
  • Publication number: 20120083533
    Abstract: A therapy for renal diseases, in particular renal diseases which develop in diabetic patients or patients who have been subjected to a treatment with an antitumor chemotherapy such as a platinum derivative and more generally cytotoxic drugs at renal level for treating of neoplastic diseases. More particularly, the present invention relates to palmitoylethanolamide and diethanolamide of fumaric acid for use in the treatment of renal diseases, in particular those caused by dysmetabolic diseases or by toxic or chemotherapy agents, such as platinum derivatives. Palmitoylethanolamide is used preferably in micronized or ultra-micronized form. Diethanolamide of fumaric acid is used preferably in aqueous solution.
    Type: Application
    Filed: October 3, 2011
    Publication date: April 5, 2012
    Inventors: Francesco Della Valle, Raffacle Migliaccio, Maria Federica Della Valle
  • Publication number: 20120021044
    Abstract: The present invention provides a novel cationic lipid, a preparation method of the same and a delivery system comprising the same. The cationic lipid of the present invention is used for the preparation of delivery systems of nucleic acids or physiologically active anionic proteins. The cationic lipid of the present invention can be conveniently prepared and purified by a simple process and is therefore economically highly advantageous for industrial-scale production thereof. Further, a nucleic acid or protein delivery system comprising the cationic lipid of the present invention not only significantly improves the intracellular delivery efficiency of desired nucleic acid drugs (such as DNAs, RNAs, siRNAs, antisense oligonucleotides, and nucleic acid aptamers) or anionic proteins having physiological activity, but also is usefully used to augment therapeutic efficacy of nucleic acid or protein drugs due to attenuated cytotoxicity of the delivery system.
    Type: Application
    Filed: August 20, 2008
    Publication date: January 26, 2012
    Applicants: SNU R&DB FOUNDATION, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Yu-Kyoung Oh, Min-Sung Suh, Hye-Jeong Shin, Ga Yong Shim
  • Publication number: 20110319516
    Abstract: Release agents with increased affinity toward nano-imprint lithography template surfaces interact strongly with the template during separation of the template from the solidified resist in a nano-imprint lithography process. The strong interaction between the surfactant and the template surface reduces the amount of surfactant pulled off the template surface during separation of a patterned layer from the template in an imprint lithography cycle. Maintaining more surfactant associated with the surface of the template after the separation of the patterned layer from the template may reduce the amount of surfactant needed in a liquid resist to achieve suitable release of the solidified resist from the template during an imprint lithography process. Strong association of the release agent with the surface of the template facilitates the formation of ultra-thin residual layers and dense fine features in nano-imprint lithography.
    Type: Application
    Filed: September 7, 2011
    Publication date: December 29, 2011
    Applicant: MOLECULAR IMPRINTS, INC.
    Inventors: Frank Y. Xu, Weijun Liu
  • Publication number: 20110318479
    Abstract: Disclosed are metal plating compositions and methods. The metal plating compositions provide good leveling performance and throwing power.
    Type: Application
    Filed: September 6, 2011
    Publication date: December 29, 2011
    Applicant: Rohm and Haas Electronic Materials LLC
    Inventors: Erik REDDINGTON, Gonzalo Urrutia DESMAISON, Zukhra I. NIAZIMBETOVA, Donald E. CLEARY, Mark LEFEBVRE
  • Publication number: 20110269652
    Abstract: The invention relates to gemini surfactants of formula IA wherein A is a core derived from an organic polyhydroxy compound; R1 and R2 are each independently a hydrophobic group; and R3 and R4 are each independently a surfactant head group. Such surfactants can be used as components of fluids used in the petroleum industry or used in formulating cleansing compositions or detergent compositions.
    Type: Application
    Filed: October 29, 2009
    Publication date: November 3, 2011
    Applicant: ST. FRANCIS XAVIER UNIVERSITY
    Inventors: D. Gerrard Marangoni, T. Bruce Grindley, Nusrat Jahan, Christian Petropolis, Thomas Tran, Nawal Paul
  • Patent number: 8017804
    Abstract: The present invention is related to a compound according to formula (I), wherein R1 and R2 are each and independently selected from the group comprising alkyl; n is any integer between 1 and 4; R3 is an acyl selected from the group comprising lysyl, ornithyl, 2,4-diaminobutyryl, histidyl and an acyl moiety according to formula (II), wherein m is any integer from 1 to 3 and YÉ is a pharmaceutically acceptable anion.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: September 13, 2011
    Assignee: Silence Therapeutics AG
    Inventors: Oliver Keil, Jörg Kaufmann
  • Patent number: 7919528
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: April 5, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Kelly M. Aubart, Andrew B. Benowitz, Siegfried B. Christensen, IV, Joseph M. Karpinski, Jinhwa Lee, Domingos J. Silva
  • Publication number: 20110070657
    Abstract: The present inventions include methods and compositions for detecting the presence of ions and measuring the level or concentration of ions in a sample by nuclear magnetic resonance (NMR) using magnetic particles. In particular, the inventions include the preparation and use of magnetic particles having synthetic ion chelators covalently bound to their surfaces. In the presence of target ions, the surface-modified magnetic particles form clusters, which can be monitored by NMR relaxation measurements. The relaxation times can then be used to detect specific ions and determine their concentration. The described methods, compositions, and devices are useful for a variety of applications including biomedical applications in diagnostics and imaging.
    Type: Application
    Filed: August 18, 2008
    Publication date: March 24, 2011
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Lee Josephson, Sonia Taktak
  • Publication number: 20110039937
    Abstract: The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient, vorinostat. In particular it relates to an efficient process for the preparation of vorinostat of high purity without the requirement to isolate any synthetic intermediate compounds.
    Type: Application
    Filed: February 6, 2009
    Publication date: February 17, 2011
    Inventors: Abhay Gaitonde, Bharati Choudhari
  • Publication number: 20110009641
    Abstract: Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Application
    Filed: June 14, 2006
    Publication date: January 13, 2011
    Inventors: Daniel G. Anderson, Andreas Zumbuehl, Elizaveta Sergeyevna Leshchiner (Turkhanova), Robert S. Langer, Michael Goldberg
  • Publication number: 20100280186
    Abstract: Aromatic polyamines are derivatized with polycarboxylic acids or their derivatives to form polyamine amides) containing pendant amine groups; the derivatives have enhanced curative properties when used as curatives for polyureas, hybrid epoxy-urethanes, hybrid urea-urethanes, chain extenders for polyurethane and polyurea elastomers, and also for reaction injection molding (RIM) products.
    Type: Application
    Filed: August 28, 2009
    Publication date: November 4, 2010
    Inventors: Herman P. Benecke, Alex W. Kawczak, Daniel B. Garbark
  • Publication number: 20100234640
    Abstract: This invention provides a comprehensive solution which comprises the production of a bed of ash-containing hot char via the pyrolysis of coal which generates a hydrogen rich gas that, subsequent to its cleanup, can be synthesized into chemicals and/or transportation fuels, while the hot char is used to: (i) reduce SO2 and NOX to elemental sulfur and to elemental nitrogen, respectively; (ii) react hot char with CO2 to reduce it to CO, a valuable chemical that can be converted into fertilizer or into a fuel gas that can be used for electric or thermal power generation; (iii) trap particulate matter in the bed of char to join the ash in the char to form a combined ash which is eventually converted to inert slag; and (iv) filter the mercury through a portion of the char to prevent it from being emitted into the atmosphere.
    Type: Application
    Filed: March 13, 2009
    Publication date: September 16, 2010
    Inventors: Albert Calderon, Terry James Laubis
  • Patent number: 7790926
    Abstract: Alpha, omega-difunctional aldaramides, in particular diaminoaldaramides, dihydroxyaldaramides, bis(alkoxycarbonylalkyl)aldaramides, and bis(carboxyalkyl)aldaramides, and processes for preparing the aldaramides are provided.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: September 7, 2010
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Mark Allen Andrews, Henry Keith Chenault, Garret D. Figuly
  • Publication number: 20100218414
    Abstract: The compounds of general formula (I) wherein: R1 is hydrogen, phenyl, C1-6 alkyl which can be further substituted with R3, R3 is 5- or 6-membered aromatic or heteroaromatic ring system which can be further substituted with benzyl or hydroxyl groups; R2 is OR4, NHR4, R4 is hydrogen, C1-6 alkyl or benzyl n is an integer from 1 to 12 or the salts of compounds mentioned which can form gels with commercial fuels, organic solvents and water.
    Type: Application
    Filed: September 4, 2008
    Publication date: September 2, 2010
    Inventors: Mladen Zinic, Janja Makarevic
  • Publication number: 20100159593
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2—Z or —Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Yongliang CHU, Malek Masoud, Gulilat Gebeyehu
  • Publication number: 20100152452
    Abstract: This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 17, 2010
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Shan-Yen Chou, Chi-Hsin Richard King
  • Publication number: 20100109195
    Abstract: Release agents with increased affinity toward nano-imprint lithography template surfaces interact strongly with the template during separation of the template from the solidified resist in a nano-imprint lithography process. The strong interaction between the surfactant and the template surface reduces the amount of surfactant pulled off the template surface during separation of a patterned layer from the template in an imprint lithography cycle. Maintaining more surfactant associated with the surface of the template after the separation of the patterned layer from the template may reduce the amount of surfactant needed in a liquid resist to achieve suitable release of the solidified resist from the template during an imprint lithography process. Strong association of the release agent with the surface of the template facilitates the formation of ultra-thin residual layers and dense fine features in nano-imprint lithography.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 6, 2010
    Applicant: MOLECULAR IMPRINTS, INC.
    Inventors: Frank Y. Xu, Weijun Liu
  • Publication number: 20100113279
    Abstract: Novel bis(dialkylamide) compounds having the formula: R2R3NOC—R1a—CONR4R5 are particularly useful solvents, for example in plant-protection formulations.
    Type: Application
    Filed: December 19, 2007
    Publication date: May 6, 2010
    Inventors: Jean-Manuel Mas, Valerio Bramati, Massimo Guglieri, Wagner Celio Ferraz Lourenco
  • Publication number: 20100080880
    Abstract: The present invention concerns geranylamine derivates of oxalic acid, use of the same as flavorings and certain mixtures, compositions, preparations and semi-finished goods containing one or more such compounds.
    Type: Application
    Filed: September 23, 2009
    Publication date: April 1, 2010
    Applicant: SYMRISE GmbH & Co. KG
    Inventors: Michael Backes, Jan Looft
  • Patent number: 7638650
    Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: December 29, 2009
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Weiming Qiu
  • Publication number: 20090314639
    Abstract: The present invention relates to means and devices for electro-filtration of molecules. The membranes comprise N-acryloyl-tris(hydroxymethyl)aminomethane (NAT) covalently linked to a support. The invention further encompasses compositions comprising an isoelectric buffer covalently bound to N-acryloyl-tris(hydroxymethyl)aminomethane (NAT). In particular, the present invention relates to membranes and devices allowing an isoelectric filtration of molecules in solution.
    Type: Application
    Filed: September 17, 2007
    Publication date: December 24, 2009
    Inventors: Michel Daniel Faupel, Jan Van Oostrum
  • Publication number: 20090305196
    Abstract: A hardenable dental composition that includes a polymerizable component and an organogelator.
    Type: Application
    Filed: September 12, 2007
    Publication date: December 10, 2009
    Inventors: Naimul Karim, Todd D. Jones, Kevin M. Lewandowski, Bradley D. Craig, Sumita B. Mitra, Jie Yang
  • Patent number: 7612236
    Abstract: It is provided that a method for producing an optically active bisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted phenyl group, a 1-naphthyl group, a 2-naphthyl group or an optionally substituted aralkyl group, R3 and R4 are the same or different, and each represents a hydrogen atom or C1-3 alkyl group, m represents an integer of 0 to 2, and * represents an asymmetric center, which comprises reacting an optically active aminoalcohol compound represented by the formula (1): wherein R1, R2 and * are as defined above, with a diester compound represented by the formula (2): wherein R3, R4 and m are as defined above and R5 represents a C1-3 alkyl group,
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: November 3, 2009
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Makoto Itagaki
  • Publication number: 20090143583
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and
    Type: Application
    Filed: January 14, 2009
    Publication date: June 4, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Yongliang CHU, Malek MASOUD, Gulilat GEBEYEHU
  • Publication number: 20090047435
    Abstract: One aspect of the invention is a compound of formula (I) Ro-[L-(CqH2qS)pCrH2rRf]2??(I) wherein Ro is a divalent organic group having 2 to 40 carbon atoms; L is a linking group selected from —NHC(O)NH— or —C(O)NH— wherein the left side of the linking group is bonded to Ro; p is an integer of 0 or 1; q is an integer of 2 to 10; r is an integer of 1 to 10; and Rf is a linear or branched C1-C6 perfluoroalkyl group. Another aspect of the invention is a composite material comprising a porous support and a porous nanoweb, wherein said porous nanoweb comprises fibrous structures of between about 10 nm and about 1000 nm effective average fiber diameter as determined with electron microscopy; said fibrous structures being comprised of one or more compositions of formula (I). Another aspect of the invention is a method for making a composite material comprising a porous support and a porous nanoweb.
    Type: Application
    Filed: August 13, 2007
    Publication date: February 19, 2009
    Inventors: Keith Ward Hutchenson, Anilkumar Raghavanpillai, Stefan Reinartz
  • Publication number: 20080221218
    Abstract: The present invention relates to synthetic receptors, products and methods which are useful in relation to the binding of phosphates for example in water purification and renal dialysis systems.
    Type: Application
    Filed: August 15, 2006
    Publication date: September 11, 2008
    Applicant: The University of York
    Inventors: Hubertus Franciscus Martinus Nelissen, David Kelham Smith
  • Patent number: 7399879
    Abstract: A process for the preparation of a monoalkylidene substituted 1,4-dions derivatives of formula (Ia) or (Ib) or a mixture of (Ia) and (Ib): wherein: R1, R2 and R3, equal to or different from each other, are hydrogen atoms or C1–C20 hydrocarbon groups: T1 and T2, equal to or different from each other, are OR4, R4, NR42, SR4 or PR42; or T1 and T2 can be fused in an oxygen atom or a NR4 group; said process comprises the step of reacting a compound of formula (II) with a compound of formula (IIIa) or (IIIb) in the presence of at least one equivalent with respect to the compound of formula (IIIa) or (IIIb) of a carbonate of metal M or of a compound of formula MTj such as K2CO3 or KHCO3
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: July 15, 2008
    Assignee: Basell Poliolefine Italia S.p.A.
    Inventors: Yuri V. Gulevich, Giampiero Morini
  • Publication number: 20080113172
    Abstract: Partially fluorinated amino acid derivatives are provided that are useful as organogelators and surface treatment materials to provide oil- and water-repellency properties to substrates. Also provided are composite materials comprising a porous support and a porous nanoweb. The porous nanoweb contains fibrous structures of about 10 nm to about 1000 nm effective average fiber diameter.
    Type: Application
    Filed: November 13, 2006
    Publication date: May 15, 2008
    Inventors: Erick Jose Acosta, Anilkumar Raghavanpillai, Sheng Peng, Stefan Reinartz
  • Patent number: 7351862
    Abstract: Alpha, omega-difunctional aldaramides, in particular diaminoaldaramides, dihydroxyaldaramides, bis(alkoxycarbonylalkyl)aldaramides, and bis(carboxyalkyl)aldaramides, and processes for preparing the aldaramides are provided.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: April 1, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Mark Allen Andrews, Henry Keith Chenault, Garret D. Figuly
  • Patent number: 7332485
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: February 19, 2008
    Assignee: SmithKline Beecham Corp
    Inventors: Kelly M. Aubart, Siegfried Benjamin Christensen, IV, Chaya Duraiswami, Joseph M. Karpinski
  • Patent number: RE41151
    Abstract: In accordance with the present invention, there are provided normal modified forms of nonsteroidal anti-inflammatory drugs. Modified NSAIDs according to the invention provide a new class of anti-inflammatory agent which provide the therapeutic benefits of NSAIDs while causing a much lower incidence of side-effects then typically observed with such agents.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: February 23, 2010
    Assignee: Medinox, Inc.
    Inventors: Ching-San Lai, Tingmin Wang