Of Compound Which Contains An Atom Other Than Carbon, Hydrogen, And Halogen Patents (Class 564/483)
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Patent number: 8519191Abstract: A synthesis method of 3-methylamino-1,2-propanediol is disclosed in the invention, and it includes the following steps: (a) adding glycerin chlorohydrin, aqueous monomethylamine solution and an amination catalyst, namely NaOH solution and NaHCO3, into a reactor, mixing the material sufficiently, and allowing amination reaction to proceed in two temperature stages; (b) removing monomethylamine and water from the amination solution after the amination reaction is completed, filtering out the solid resultant, and feeding the filtrate into a still; (c) distilling under reduced pressure to obtain 3-methylamino-1,2-propanediol, wherein the vacuum for distillation under reduced pressure is equal to or greater than 0.099 MPa and the temperature is 130-160° C.Type: GrantFiled: March 12, 2010Date of Patent: August 27, 2013Assignee: Weifang PBNS Chem. Industry Co., LtdInventors: Zhongfa Zhang, Xueyang Guo, Hui Huang
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Patent number: 7652170Abstract: Disclosed is a method for producing a primary amine compound represented by the formula (2) below, which is characterized in that a halogen compound represented by the formula (1) below, ammonia and formaldehyde are reacted with each other, and then the thus-obtained reaction product is [1] brought into contact with an aqueous solution of an acid or [2] reacted with a hydroxylamine under acidic conditions. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product. (1) (In the formula, R1 and R2 independently represent a hydrogen atom, a C1-C5 alkyl group which may be substituted by a halogen atom or the like, a C1-C5 alkoxy group which may be substituted by a halogen atom, a cyano group, a C2-C11 alkenyl group or a phenyl group or the like; R3 represents a hydrogen atom, a linear or branched C1-C5 alkyl group or a cyano group; and X represents a halogen atom.Type: GrantFiled: December 25, 2006Date of Patent: January 26, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroshi Souda, Naoyuki Takano, Shinzo Seko
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Patent number: 6984759Abstract: Process for the perfluoropolyether preparation having reactive end groups —CH2NH2, —CHO, —CH2OH, by reduction of the corresponding perfluoropolyethers having —CN, —COCl, —CHO end groups by using gaseous hydrogen in the presence of a catalyst constituted by Pd, Rh, or Ru, supported on solid metal fluorides, at a temperature from 20° C. to 150° C. and under a pressure between 1 and 50 atm.Type: GrantFiled: July 31, 2003Date of Patent: January 10, 2006Assignee: Solvay Solexis S.p.A.Inventors: Antonella Di Meo, Rosaldo Picozzi, Claudio Tonelli
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Patent number: 6852887Abstract: The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.Type: GrantFiled: March 4, 2003Date of Patent: February 8, 2005Assignee: Aerojet Fine Chemicals LLCInventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
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Publication number: 20040236151Abstract: The invention relates to a method of preparing enantiomerically enriched amino alcohols of Formula I 1Type: ApplicationFiled: March 19, 2004Publication date: November 25, 2004Applicant: Pfizer, Inc.Inventors: Steven P. Tanis, James A. Nieman
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Patent number: 6806379Abstract: A continuous process for preparing alkylamines comprises reacting continuous streams of ammonia and alkyl halide in a molar ratio of at least 10:1 in a pressure reactor. The ultimate reaction mixture has a temperature of >80° C., a pressure of >40 bar and an ammonium halide content of >1% by weight, and comprises two phases (A) a first phase comprising at least 75% by weight of the total amount of ammonium halide formed, and (B) a second phase comprising at least 80% by weight of the total amount of alkylamine formed. The first and second phases are separated, and an alkylamine product is recovered therefrom.Type: GrantFiled: December 30, 2002Date of Patent: October 19, 2004Assignee: Consortium fuer elektrochemische Industries GmbHInventors: Andreas Bauer, Herbert Jekat, Jochen Rauch, Peter John, Wolfgang Kohlmann, Volker Frey, Bernd Pachaly
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Patent number: 6649780Abstract: Cationic lipids are provided which are useful in the preparation of liposomes and other lipid vesicle carriers. The lipids of the invention are particularly useful as carriers of nucleic acids and other negatively charged substances, for delivery to cells.Type: GrantFiled: December 17, 1999Date of Patent: November 18, 2003Assignees: Valentis, Inc., Max-Planck-Gesellschaft zur Foerderung der Wissaschaften B.V.Inventors: Hansjörg Eibl, Jinkang Wang, Yi Lin Zhang
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Patent number: 6548706Abstract: The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present inventin can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.Type: GrantFiled: December 22, 2000Date of Patent: April 15, 2003Assignee: Aerojet Fine Chemicals LLCInventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, Roland P. Carlson, John Leach, Thomas G. Archibald, Robert G. Miotke
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Patent number: 5874623Abstract: Disclosed herein is a method of preparing polyether aminoalcohol by reacting a primary aminoalcohol with a polyether terminated with a good leaving group.Type: GrantFiled: August 2, 1993Date of Patent: February 23, 1999Assignee: Bayer CorporationInventors: Rick L. Adkins, William E. Slack
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Patent number: 5872298Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.Type: GrantFiled: April 9, 1997Date of Patent: February 16, 1999Assignee: G. D. Searle & Co.Inventors: John S Ng, Claire A Przybyla, Richard A Mueller, Michael L Vazquez, Daniel P Getman, John J Freskos, Gary A DeCrescenzo, Deborah E Bertenshaw, Robert M Heintz, Suhong Zhang, Chin Liu, Scott A Laneman
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Patent number: 5498707Abstract: A composition adapted to convert hydrogen sulfide and organic sulfides to nontoxic polymers. The compositions comprise amine resin solutions made by reacting sterically hindered amines such as selected diamines, triamines, amino alcohols, and mixtures thereof, with aldehydes, aldehyde donors, or the reaction products of lower alkanolamines and lower aldehydes. The subject compositions are preferably made by reacting the sterically hindered amines and aldehyde components in about a 1:1 molar ratio at a temperature ranging from about 110.degree. to about 120.degree. F. (about 43.degree. to about 49.degree. C.), using enough of the sterically hindered amine to produce a reaction product having a pH ranging from about 10.5 to about 12. Streams containing hydrogen sulfide or organic sulfides are preferably treated by contacting such streams with from about 2 to about 4 ppm of the amine solution of the invention per ppm of sulfide.Type: GrantFiled: May 6, 1994Date of Patent: March 12, 1996Inventor: Larry W. Gatlin
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Patent number: 5488103Abstract: A composition adapted to convert hydrogen sulfide and organic sulfides to nontoxic polymers. The compositions comprise amine resin solutions made by reacting sterically hindered amines such as selected diamines, triamines, amino alcohols, and mixtures thereof, with aldehydes, aldehyde donors, or the reaction products of lower alkanolamines and lower aldehydes. The subject compositions are preferably made by reacting the sterically hindered amines and aldehyde components in about a 1:1 molar ratio at a temperature ranging from about 110.degree. to about 120.degree. F. (about 43.degree. to about 49.degree. C.), using enough of the sterically hindered amine to produce a reaction product having a pH ranging from about 10.5 to about 12. Streams containing hydrogen sulfide or organic sulfides are preferably treated by contacting such streams with from about 2 to about 4 ppm of the amine solution of the invention per ppm of sulfide.Type: GrantFiled: May 15, 1995Date of Patent: January 30, 1996Inventor: Larry W. Gatlin
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Patent number: 5486605Abstract: A composition is disclosed that is adapted to convert hydrogen sulfide and organic sulfides to nontoxic polymers. The compositions comprise amine resin solutions made by reacting sterically hindered amines such as amine heads with aldoses selected from the group consisting of D-aldoses having from 3 to 6 carbon atoms. Streams containing hydrogen sulfide or organic sulfides are preferably treated by contacting such streams with from about 2 to about 4 ppm or more of the amine solution of the invention per ppm of sulfide.Type: GrantFiled: May 20, 1994Date of Patent: January 23, 1996Inventor: Larry W. Gatlin
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Patent number: 5440049Abstract: A compound of the formula: ##STR1## wherein R.sup.11 is hydrogen, lower alkyl, haloloweralkyl, lower alkenyl, lower alkynyl or cycloalkyl and R.sup.21 is a group selected from the group consisting of: ##STR2## wherein R.sup.3 -R.sup.5, R.sup.31, R.sup.32, R.sup.41, R.sup.42 and R.sup.51 are as defined herein, and W is chlorine or bromine, is prepared by reacting a compound of the formula:Z--CH.sub.2 --CH.dbd.CH--W (I)wherein W is as defined above and Z is a leaving group, with an amine of the formula: ##STR3## wherein R.sup.11 and R.sup.21 are as defined above.Type: GrantFiled: June 13, 1994Date of Patent: August 8, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Susumu Nakagawa, Akira Asai, Satoru Kuroyanagi, Makoto Ishihara, Yoshiharu Tanaka
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Patent number: 4792630Abstract: A process for preparing an aminoacetaldehyde dialkyl acetal which comprises reacting a halogenoacetaldehyde dialkyl acetal with ammonia or an alkylamine in an aqueous medium in the simultaneous presence of an alkali metal hydroxide or of an alkaline earth metal hydroxide, and distilling the resulting reaction mixture.Type: GrantFiled: February 13, 1987Date of Patent: December 20, 1988Assignee: Nippon Gosei Kagaku Kogyo Kabushiki KaishaInventors: Akira Taisha, Takeo Kawabata, Takehiko Kakimoto, Kazumasa Hirata
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Patent number: 4760189Abstract: The present invention relates to a new process for the preparation of diamine-alcohols.The process according to the present invention relates to the preparation of compounds of the formula:R--NH--CH.sub.2 --CH(OH)--CH.sub.2 NH.sub.2in which R is a C.sub.1 to C.sub.30 alkyl radical, characterized in that ammonia is reacted with the compound of the formula: ##STR1## in which R has the meaning given above and X is a halogen atom.Type: GrantFiled: September 3, 1986Date of Patent: July 26, 1988Assignee: Laboratories PharmascienceInventors: Martine Mercier, Alain Rancurel
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Patent number: 4731689Abstract: A method and a device for directional detection of a fault on a power transmission line extending between two stations (P, Q). In one of the stations (P) there is a travelling wave model which, by means of currents and voltages measured in the station, calculates the voltage distirbution along the line. The direction to a fault is determined by monitoring changes in calculated voltages in the two stations. If a fault occurs between the stations, the voltage change occurring in a station (Q) between the voltage existing prior to a fault and after a fault can be estimated as .vertline..DELTA.Uq.vertline., and the corresponding voltage change occurring in the other station (P) can be estimated as .vertline..DELTA.Up.vertline., whereby according to the invention the difference .vertline..DELTA.Uq.vertline.-.vertline..DELTA.Up.vertline.>0 signifies a fault on the line side of the station (P), i.e. a fault lying ahead of the measuring point. A fault lying behind station P is evidenced when .vertline..DELTA.Uq.Type: GrantFiled: March 27, 1987Date of Patent: March 15, 1988Assignee: ASEA ABInventors: Gunnar Nimmersjo, Murari M. Saha
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Patent number: 4725680Abstract: The invention relates to a process for preparing carbamic acid derivatives of formula: ##STR1## in which R.sup.1 or R.sup.2 denotes a hydrogen atom or a substituted or unsubstituted, saturated or unsaturated aliphatic, cycloaliphatic or heterocyclic radical, or R.sup.1 and R.sup.2 together form a ring, and Y denotes OR, SR, ##STR2## groups, R being a substituted or unsubstituted, saturated or unsaturated aliphatic or cycloaliphatic radical, or a substituted or unsubstituted aromatic radical, R.sup.3 and R.sup.4 denote a hydrogen atom or an aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical or together form a ring, and R.sup.6 and R.sup.7 denote a saturated or unsaturated, substituted or unsubstituted aliphatic or cycloaliphatic radical, a hydrogen atom, an alkylthio radical or an alkyloxy radical.According to the process, a compound of formula ##STR3## is reacted with an .alpha.-halogenated derivative of formula ##STR4## at a temperature of -5.degree. to 150.degree. C.Type: GrantFiled: February 14, 1985Date of Patent: February 16, 1988Assignee: Societe Nationale des Poudres et ExplosifsInventors: Gerard Barcelo, Jean-Pierre Senet, Gerard Sennyey
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Patent number: 4665234Abstract: A novel class of severely sterically hindered secondary aminoether alcohols of the general formula: ##STR1## are prepared wherein R.sub.1 and R.sub.2 are each selected from the group consisting of alkyl and hydroxylalkyl radicals R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each selected from the group consisting of hydrogen, alkyl and hydroxyalkyl radicals, with the proviso that at least one of R.sub.4 or R.sub.5 bonded to the carbon atom directly bonded to the nitrogen atom is an alkyl or hydroxyalkyl radical when R.sub.3 is hydrogen, x and y are each positive integers ranging from 2-4 and z is a positive integer ranging from 1-4. The compounds are useful in the selective removal of H.sub.2 S from mixtures containing H.sub.2 S and CO.sub.2.Type: GrantFiled: August 15, 1983Date of Patent: May 12, 1987Assignee: Exxon Research and Engineering CompanyInventor: Eugene L. Stogryn
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Patent number: 4587353Abstract: There is described a process for producing N-chlorosulfenyl compounds of the formula ##STR1## in which R.sub.1 is alkyl, alkoxycarbonyl, alkoxycarbonylalkyl or 2,3-dihydro-2,2-dimethylbenzofuran-7-yloxycarbonyl, and R.sub.2 is alkyl or alkoxycarbonylalkyl, which process is based on the reaction of an amino compound of the formula ##STR2## with sulfur dichloride. The essential feature of the process is that the reaction of the amino compound of the above formula with the sulfur dichloride is performed in excess sulfur dichloride as solvent and in the absence of a base. The formed N-chlorosulfenyl compounds of the above formula are intermediates for insecticidal and acaricidal active substances.Type: GrantFiled: August 23, 1983Date of Patent: May 6, 1986Assignee: Ciba-Geigy CorporationInventor: Hansjakob Fah