Sulfur Or Oxygen Bonded Directly To Phosphorus Patents (Class 568/14)
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Publication number: 20110218130Abstract: Salts of the anion of di-, tri- or tetrathiophosphoric acid of the formula I in which Z1 and Z2 are each independently an oxygen or sulfur atom, and Ra and Rb are each independently an organic group having 1 to 20 carbon atoms, and a cation which comprises a heterocyclic ring system having one to three nitrogen atoms.Type: ApplicationFiled: March 7, 2011Publication date: September 8, 2011Applicants: BASF SE, ILCO Chemikalien GmbHInventors: Laszlo SZARVAS, Dirk GERHARD, Matthias VOLKHOLZ, Corvin VOLKHOLZ
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Patent number: 8008529Abstract: Ligands of the formula (I) secondary phosphine-Q-P(?O)HR1 (I) in the form of mixtures of diastereomers or pure diastereomers, in which secondary phosphine is a secondary phosphine group with hydrocarbon radicals or heterohydrocarbon radicals as substituents; Q is a bivalent bisaryl or bisheteroaryl radical with an axial chiral centre to which the two phosphorus atoms are bonded in the ortho positions to the bisaryl or bisheteroaryl bridge bond, or Q is a bivalent ferrocenyl radical with a planar chiral centre or without a planar chiral centre, to which the phosphorus atom of the secondary phosphine is bonded directly or via a C1-C4-carbon chain to a cyclopentadienyl ring, the —P*(?O)HR1 group is bonded either on the same cyclopentadienyl ring in ortho position to the bonded secondary phosphine or on the other cyclopentadienyl ring; P* is a chiral phosphorus atom, and R1 is a hydrocarbon radical, a heterohydrocarbon radical or a ferrocenyl radical, where R1 is a ferrocenyl radical with a planar chiral centre wType: GrantFiled: May 23, 2007Date of Patent: August 30, 2011Assignee: Solvias AGInventors: Andreas Pfaltz, Yann Ribourdouille, Xiangdong Feng, Balamurugan Ramalingam, Benoît Pugin, Felix Spindler
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Publication number: 20110124873Abstract: The invention relates to bis(perfluoroalkyl)phosphinous acids, bis(perfluoroalkyl)thiophosphinous acids and derivatives, the synthesis thereof and the use thereof, in particular for the synthesis of air-stable metal complexes for catalytic processes.Type: ApplicationFiled: July 10, 2009Publication date: May 26, 2011Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Berthold Hoge, Anne Julia Bader, Boris Kurscheid, Nikolai Ignatyev, Emil Ferdinand Aust
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METHOD FOR PRODUCING BIS(FLUORALKYL)PHOSPHINIC ACID CHLORIDES OR FLUORALKYLPHOSPHONIC ACID CHLORIDES
Publication number: 20110124921Abstract: The invention relates to a process for the preparation of bis(fluoroalkyl)phosphinyl chlorides or fluoroalkylphosphonyl dichlorides by reaction of the corresponding bis(fluoroalkyl)phosphinic acid or fluoroalkylphosphonic acid with aryltetrachlorophosphorane as chlorinating agentType: ApplicationFiled: June 24, 2009Publication date: May 26, 2011Applicant: MERCK PATENT GESELLSCHAFTInventors: Nikolai(Mykola) Ignatyev, Dana Bejan, Helge Willner, Emil Aust -
Publication number: 20110118482Abstract: Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the —P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group Z1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*R0R1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally iType: ApplicationFiled: November 14, 2008Publication date: May 19, 2011Inventors: Benoît Pugin, Matthias Lotz, Heidi Landert, Adrian Wyss, Raphael Aardoom, Bjõrn Gschwend, Andreas Pfaltz, Felix Spindler
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Publication number: 20110098485Abstract: Compounds of the formula I, in the form of mixtures comprising predominantly one enantiomer or in the form of pure enantiomers, secondary phosphine-Q-P*(?O)HR1 (I) in which secondary phosphine is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*(O)HR1 is bonded to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; and R1 is a hydrocarbon radiType: ApplicationFiled: November 14, 2008Publication date: April 28, 2011Inventors: Benoît Pugin, Heidi Landert, Björn Gschwend, Andreas Pfaltz, Felix Spindler
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Publication number: 20110098507Abstract: The object of the invention is the use of phosphonic acids of the formula (4), where R2 is H or C1-C500-alkyl, and R3 and R4 independently from each other are H or C1-C500-alkyl, with the proviso that not all groups R2, R3, R4 are hydrogen, and having a molecular weight from 250 to 10,000 units, in quantities from 0.5 to 10,000 ppm with respect to the oil, for the dispersion of asphaltenes in asphalt-containing crude oils or residual oils.Type: ApplicationFiled: December 3, 2008Publication date: April 28, 2011Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Carsten Cohrs, Stefan Dilsky, Dirk Leinweber, Michael Feustel
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Publication number: 20110065869Abstract: A hydroxyphenyl or alkoxyphenyl phosphine oxide composition comprising (i) a first mixture of mono-(hydroxyphenyl) or (alkoxyphenyl) phosphine oxide isomers, (ii) a second mixture of bis-(hydroxyphenyl) or (alkoxyphenyl) phosphine oxide isomers, (iii) a third mixture of tris-(hydroxyphenyl) or (alkoxyphenyl) phosphine oxide isomers, and optionally iv) a minority amount of non-hydroxy or non-alkoxy tris-phenyl phosphine oxides is provided.Type: ApplicationFiled: September 10, 2010Publication date: March 17, 2011Inventors: Larry D. Timberlake, Mark V. Hanson, James D. Sibecker
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Patent number: 7902403Abstract: The present invention relates to oligomeric or polymer dithiophosphate di- or poly-sulfides and their utility in rubbers. Another aspect of the invention is a method for making oligomeric or polymeric dithiophosphates by reacting phosphorous pentasulfide with a di- or polyol and a mono alcohol to produce a dithiophosphoric acid, and then oxidizing the dithiophosphoric acid with an oxidizing agent to produce an oligomeric or polymeric dithiophosphate.Type: GrantFiled: January 31, 2008Date of Patent: March 8, 2011Assignee: R.T. Vanderbilt Company, Inc.Inventors: Thomas J. Karol, Ronald J. Tepper
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Patent number: 7888534Abstract: A method for preparing substantially pure optionally substituted diaryl alkylphosphonates from an optionally substituted triarylphosphite and an optionally substituted trialkylphosphite or an optionally substituted alkanol under special reaction conditions is described.Type: GrantFiled: October 17, 2006Date of Patent: February 15, 2011Assignee: FRX Polymers, Inc.Inventors: Dieter Freitag, Savvas Hadjikyriacou
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Publication number: 20110034734Abstract: The present invention relates to unsaturated diphosphine monoxides, to a process for preparation thereof and to the use thereof as flame retardants.Type: ApplicationFiled: March 23, 2009Publication date: February 10, 2011Applicant: BASF SEInventors: Alexander Tishkov, Klemens Massonne
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Patent number: 7884248Abstract: A beneficial method for the manufacture of amino polyalkylene phosphonic acids, under substantial absence of hydrohalogenic acid, is disclosed. The method, in essence, is based on reacting narrowly defined ratios of phosphorous acid, an amine, a formaldehyde in presence of specific ranges of an acid catalyst having a pKa equal or inferior to 3.1. The inventive method is capable of yielding economically and quality operational/capacity advantages, in particular significantly reduced one-step cycle duration under exclusion, of corrosion disadvantages and also is environmentally friendly without requiring, in that respect, anything more than nominal capital expenditures.Type: GrantFiled: November 7, 2005Date of Patent: February 8, 2011Assignee: Thermphos Trading GmbHInventors: Patrick P. Notte, Isabelle Emmanuel Vanesse, Jan H. J. Van Bree
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Patent number: 7875739Abstract: Methods and kits for decomposing organophosphorus compounds in non-aqueous media at ambient conditions are described. Insecticides, pesticides, and chemical warfare agents can be quickly decomposed to non-toxic products. The method comprises combining the organophosphorus compound with a non-aqueous solution, preferably an alcohol, comprising metal ions and at least a trace amount of alkoxide ions. In a first preferred embodiment, the metal ion is a lanthanum ion. In a second preferred embodiment, the metal ion is a transition metal.Type: GrantFiled: March 5, 2007Date of Patent: January 25, 2011Assignee: Queen's University at KingstonInventors: R. Stanley Brown, Alexei A. Neverov, Josephine S. W. Tsang
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Publication number: 20110015155Abstract: The present disclosure provides biologically active deuterated 2,4-pyrimidinediamine compounds and prodrugs thereof, compositions comprising the deuterated compounds, intermediates and methods for synthesizing the deuterated compounds and methods of using the deuterated compounds in a variety of applications.Type: ApplicationFiled: July 16, 2010Publication date: January 20, 2011Applicant: RIGEL PHARMACEUTICALS, INC.Inventors: Somasekhar Bhamidipati, Rajinder Singh, Jeffrey Clough
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Patent number: 7872156Abstract: Novel fluorophosphite compounds having the structure of general formula (I): where Ar1 and Ar2 are aryl groups containing 4 to 30 carbon atoms; R1 to R6 are H or alkyl or aryl hydrocarbon radicals containing 1 to 40 carbon atoms; and X is a connecting group or a simple chemical bond, were developed and found to be very active for hydroformylation processes for ethylenically unsaturated substrates. Catalyst solutions prepared from these compounds with a Rh metal show an unusual “ligand acceleration effect” for simple alkenes, i.e., the hydroformylation activity increases as the concentration of ligand increases, and are capable of producing linear or branched aldehydes under typical hydroformylation conditions.Type: GrantFiled: December 8, 2008Date of Patent: January 18, 2011Assignee: Eastman Chemical CompanyInventors: Yun-Shan Liu, Jody Lee Rodgers
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Patent number: 7872157Abstract: Novel trivalent organophosphonite ligands having the structure of general formula (I): wherein R is an alkyl or aryl group containing 1 to 30 carbon atoms; Ar1 and Ar2 are aryl groups containing 4 to 30 carbon atoms; R1 to R6 are H or alkyl or aryl hydrocarbon radicals containing 1 to 40 carbon atoms; and X is a connecting group or a simple chemical bond, were developed and found to be very active for hydroformylation processes for ethylenically unsaturated substrates. Catalyst solutions prepared from these ligands with a Rh metal show an unusual “ligand acceleration effect” for simple alkenes, i.e., the hydroformylation activity increases as the concentration of ligand increases, and are capable of producing linear or branched aldehydes under typical hydroformylation conditions.Type: GrantFiled: December 8, 2008Date of Patent: January 18, 2011Assignee: Eastman Chemical CompanyInventors: Yun-Shan Liu, Jody Lee Rodgers
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Publication number: 20100323990Abstract: The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.Type: ApplicationFiled: June 21, 2007Publication date: December 23, 2010Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond Andersen, Matthew Nodwell, Alice Mui
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Publication number: 20100324337Abstract: There is provided a process capable of preventing the adhesion of a catalyst to an evaporator in a step of separating a chlorophosphite as a target substance from a reaction liquid by evaporation. The process includes a first step of allowing phosphorus trichloride and a phosphorous acid triester represented by (RO)3P to react in the presence of a catalyst having a viscosity at 80° C. of 100 mPa·s or lower to produce a chlorophosphite represented by RO(R?)PCl, and a second step of vaporizing a reaction liquid containing the chlorophosphite obtained in the first step, in a short time, to separate the catalyst.Type: ApplicationFiled: December 5, 2008Publication date: December 23, 2010Applicant: NIPPON CHEMICAL INDUSTRIAL CO., LTD.Inventors: Kentaro Sasaki, Katsuhiko Tsunashima, Tadashi Saito, Yoshifusa Hara
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Patent number: 7851656Abstract: Method of producing compounds of the general formula XPR2(OR1)??Ia where X is chlorine, bromine or iodine and R1 is an organic radical, by reacting compounds of the general formula X2PR2??II, in which X has the meaning given above and R2 is an organic radical, with compounds of the general formula R1OH??III, in which R1 has the meaning given above, to give a mixture IV, in that a) the postreaction is carried out at a temperature of from 50 to 240° C. and a pressure of from 0.001 to 0.9 bar, b) from the mixture IV the compounds Ia are separated off from the compounds PR2(OR1)2??Ib and, if appropriate, the compounds II and c) compounds Ib and, if appropriate, unreacted compounds II are returned to the synthesis stage.Type: GrantFiled: July 3, 2007Date of Patent: December 14, 2010Assignee: BASF SEInventors: Robert Baumann, Tobias Aechtner, Wolfgang Siegel, Hermann Luyken, Peter Pfab, Jens Scheidel, Andreas Leitner, Andreas Glass
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Publication number: 20100305296Abstract: The invention relates to an improved linear microdialysis probe comprising a continuous length of flexible tubing (1) having at least one window (4) formed therein, said window covering at least one pan of the circumference of the tubing, while the remaining part forms at least one unbroken connection between a first end of said tubing and a second end of said tubing, said ends adapted to be attached to an inlet for perfusion liquid and the other end forming an outlet for the dialysate, said at least one window (4) exposing a tubular semipermeable membrane (2).Type: ApplicationFiled: December 21, 2006Publication date: December 2, 2010Applicant: TORAY INDUSTRIES INC.Inventors: Hua Qi, Keisuke Honda, Kunihiro Morimoto, Jun Sakamoto, Hiroji Kojima
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Publication number: 20100292084Abstract: A novel process of preparing tridentate ligands containing one or more of a diarylphosphine and/or dialkylphosphine electron donating groups are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing and dialkylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed. Novel precursor molecules useful for preparing the tridentate ligands and processes of preparing same are also disclosed.Type: ApplicationFiled: May 13, 2010Publication date: November 18, 2010Applicant: Technion Research & Development Foundation Ltd.Inventors: Mark GANDELMAN, Elaine Melissa Schuster, Gennady Nisnevich
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Patent number: 7820862Abstract: Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclosed are a method for producing such an asymmetric ligand, and a catalyst using such an asymmetric ligand. Specifically disclosed is a ligand represented by the general formula I below or the like. (In the formula, R1 and R2 independently represent 0-5 substituents; X represents P, As or N; m represents an integer of 0-7; n represents an integer of 0-3; A1-A4 independently represent hydrogen, fluorine, chlorine, bromine, benzoyl or acetyl, or alternatively A2 and A3 combine together to form a ring.Type: GrantFiled: March 2, 2007Date of Patent: October 26, 2010Assignee: The University of TokyoInventors: Masakatsu Shibasaki, Motomu Kanai, Ikuo Fujimori, Kenzo Yamatsugu, Shin Kamijo
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Publication number: 20100267991Abstract: Disclosed is a method for making a diphosphite of Structure I,Type: ApplicationFiled: April 15, 2010Publication date: October 21, 2010Applicant: INVISTA NORTH AMERICA S.A.R.L.Inventors: JOACHIM C. RITTER, Thomas E. Vos
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Publication number: 20100267990Abstract: Disclosed is a method for making a diphosphite of Structure I,Type: ApplicationFiled: April 15, 2010Publication date: October 21, 2010Applicant: INVISTA NORTH AMERICA S.A R.L.Inventors: JOACHIM C. RITTER, Thomas E. Vos
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Patent number: 7799293Abstract: Methods of separating actinides from lanthanides are disclosed. A regio-specific/stereo-specific dithiophosphinic acid having organic moieties is provided in an organic solvent that is then contacted with an acidic medium containing an actinide and a lanthanide. The method can extend to separating actinides from one another. Actinides are extracted as a complex with the dithiophosphinic acid. Separation compositions include an aqueous phase, an organic phase, dithiophosphinic acid, and at least one actinide. The compositions may include additional actinides and/or lanthanides. A method of producing a dithiophosphinic acid comprising at least two organic moieties selected from aromatics and alkyls, each moiety having at least one functional group is also disclosed. A source of sulfur is reacted with a halophosphine. An ammonium salt of the dithiophosphinic acid product is precipitated out of the reaction mixture. The precipitated salt is dissolved in ether.Type: GrantFiled: September 11, 2006Date of Patent: September 21, 2010Assignee: Battelle Energy Alliance, LLCInventors: Dean R. Peterman, John R. Klaehn, Mason K. Harrup, Richard D. Tillotson, Jack D. Law
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Publication number: 20100221809Abstract: This invention is directed to compositions and methods for the isolation and further characterization of eukaryotic, mammalian, and/or human PC-PLC. In addition, the present invention discloses methods for the synthesis of an affinity chromatography resin for the isolation and purification of biologically active proteins, including eukaryotic PC-PLC.Type: ApplicationFiled: December 15, 2009Publication date: September 2, 2010Inventors: Henry J. Forman, Matthew P. Meyer
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Patent number: 7777080Abstract: The invention relates to carboxylic acid derivates which contain at least one organically polymerisable group and at least one group which contains phosphorous and is reactive or that modulates the properties of the molecule. The invention also relates to a method for production of the inventive molecules and the use thereof in dentistry and for influencing the properties of materials.Type: GrantFiled: September 11, 2003Date of Patent: August 17, 2010Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventors: Herbert Wolter, Somchith Nique
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Patent number: 7767861Abstract: The present invention relates to a process for preparing organophosphites, organophosphonites and organophosphinites by condensing phosphorus trihalides or organophosphorus halides with organic compounds bearing hydroxyl groups in the presence of polymeric basic ion exchange resins. The process according to the invention makes possible in a simple manner the preparation of trivalent organophosphorus compounds which may be used, for example, as ligands in rhodium complexes which may be used as a catalyst in hydroformylation.Type: GrantFiled: October 29, 2004Date of Patent: August 3, 2010Assignee: Evonik Oxeno GmbHInventors: Dagmara Ortmann, Klaus-Diether Wiese, Oliver Moller, Dirk Fridag
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Publication number: 20100190901Abstract: The invention relates to alkylphosphonous acids, salts and esters of formula (I) A-P(?O)(OX)—H (I) wherein A is C2-C20alkyl, C2-C20alkylene, and C8-C20 alkaryl are optionally substituted, and X is H, alkyl, aryl, alkylaryl, alkenyl, substituted alkyl, aryl, alkaryl, alkenyl, ammonium, primary, secondary, tertiary, quaternary alkyl and/or aryl ammonium, an alkali metal, an alkaline earth metal, a metal of the third and fourth main group and the second, fourth and eight sub-group or a metal of the lanthanoid group. The invention also relates to methods for producing same and to the uses of said compounds.Type: ApplicationFiled: July 2, 2008Publication date: July 29, 2010Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Michael Hill, Harald Bauer, Werner Krause
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Publication number: 20100187505Abstract: The present invention relates to the compounds of the formula (1) and to organic electroluminescent devices, in particular blue-emitting devices, in which these compounds are used as host material or dopant in the emitting layer and/or as hole-transport material and/or as electron-transport material.Type: ApplicationFiled: April 29, 2008Publication date: July 29, 2010Inventors: Philipp Stoessel, Arne Buesing, Holger Heil
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Patent number: 7759522Abstract: A crude phosphate ester product can be purified by first washing it with chelating agent composition (such as a dilute acidic solution) and then, preferably, water, drying the resulting product, and then treating the resulting product with an acid scavenger, as exemplified by an epoxy-containing compound, such as 3,4-epoxy cyclohexyl methyl-3,4-epoxy cyclohexyl carboxylate.Type: GrantFiled: February 8, 2002Date of Patent: July 20, 2010Assignee: Supresta LLCInventors: Danielle A. Bright, Eric W. Burkhardt, Antoon ten Kate, Sophia Dashevsky, John Tomko
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Publication number: 20100174007Abstract: A haloneopentyl dialkylphosphate ester possesses the general formula wherein each X is Br or Cl, provided at least two of X are Br, and R1 and R2 each independently is alkyl of up to 12 carbon atoms.Type: ApplicationFiled: January 2, 2008Publication date: July 8, 2010Inventors: Yinzhong Guo, Andrew M. Piotrowski, Anantha N. Desikan, Sophia Dashevsky
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Publication number: 20100174079Abstract: Disclosed is a process for producing an optically active phosphorus compound having an R- or S-type absolute configuration on phosphorus in a simple manner and at high efficiency, while avoiding racemization. An optically active phosphorus compound having an R- or S-type absolute configuration on phosphorus represented by the general formula (III) can be produced by reacting an optically active phosphorus compound having an R- or S-type absolute configuration on phosphorus represented by the general formula (I) with a metal compound represented by the general formula (II) and water. (I) wherein R1 represents a hydrogen atom, analkyl group, a cycloalkyl group, an aralkyl group or an aryl group; and R2 represents a hydrogen, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, alkenyl group, an alkoxy group, an aryloxy group, a heterocyclic ring residue or a silyl-containing group. R3M (II) wherein R3 is the same as R2; and M represents a lithium or magnesium halide MgX (X?Cl, Br or I).Type: ApplicationFiled: August 20, 2007Publication date: July 8, 2010Applicant: National Institute of Advanced Industrial Science TechnologyInventors: Li-Biao Han, Qing Xu
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Publication number: 20100168403Abstract: A refolding agent and refolding method which makes it possible to produce high-purity proteins in high productivity. The refolding agent includes a phosphorus-containing compound (A) and an oxycarbonyl group-containing compound (B). The refolding method includes the step of treating the unfolded protein with the refolding agent. As the compound (A), there may be at least one selected from inorganic phosphoric acids, alkyl phosphate esters, sugar phosphate esters, and salts of these, and as the compound (B), there may be at least one selected from formic acid, acetic acid, propionic acid, lactic acid, tartaric acid, and salts of these.Type: ApplicationFiled: March 2, 2010Publication date: July 1, 2010Inventors: Shunichlro Yamaguchi, Shuii Mjura
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Patent number: 7745666Abstract: A bisphosphite represented by the general formula (I): General Formula (I) (in the formula, A represents an alkylene group which may have a substituent, a cycloalkylene group which may have a substituent, a phenylene group which may have a substituent, or a naphthylene group which may have a substituent; and R1 represents a hydrogen atom or an alkyl group) and a method for producing an aldehyde including reacting a non-conjugated diene having a carbon-carbon double bond in a molecular end and having from 6 to 20 carbon atoms with a carbon monoxide and hydrogen in the presence of such a bisphosphite and a group 8 to 10 metal compound, are provided.Type: GrantFiled: April 3, 2007Date of Patent: June 29, 2010Assignee: Kuraray Co., Ltd.Inventors: Takashi Sugioka, Jin Tokuyasu, Takuo Tsuruta, Hideharu Iwasaki
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Publication number: 20100160260Abstract: The present invention embraces compounds selected for interacting with the T-pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.Type: ApplicationFiled: February 8, 2010Publication date: June 24, 2010Inventor: Emmanuel Skordalakes
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Publication number: 20100137643Abstract: The present invention relates to a process for preparing cyclohexyl-substituted phosphines. The invention further relates to a process for preparing cyclohexyl-substituted phosphine oxides which can be used as intermediates in the preparation of cyclohexyl-substituted phosphines.Type: ApplicationFiled: May 7, 2008Publication date: June 3, 2010Applicant: Basf SEInventors: Alexander Tishkov, Klemens Massonne, Daniela Mirk, Jochem Henkelmann, Matthias Maase, Thomas Wettling
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Patent number: 7714167Abstract: The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.Type: GrantFiled: January 22, 2007Date of Patent: May 11, 2010Assignees: University of Chicago, Japan Science & Technology AgencyInventors: Hisashi Yamamoto, Arindrajit Basak, Wei Zhang
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Patent number: 7705065Abstract: A photoinitiator compound is functionalized with alkoxy groups so as to be soluble in alkoxy-containing monomers. The photoinitiator has a formula of R1—(OR2)n—OC(?O)—R3, wherein R1—(OR2)n— represents an alkoxy group and R3 represents a photoinitiator structure. The photoinitiator may be used in a composition for incorporation into inks.Type: GrantFiled: August 28, 2007Date of Patent: April 27, 2010Assignee: Xerox CorporationInventor: Jennifer L. Belelie
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Publication number: 20100075926Abstract: The invention provides methods and compounds for the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (Amyotrophic Lateral Sclerosis), traumatic brain injury, ischemic brain injury or a stroke. In one aspect the compounds are HDAC1 activators. Exemplary HDAC1 activators include metal chelators, iron chelators, deferoxamin, flavonoids, compounds comprising a catechol moity, ginkgetin K, Chembridge 5104434, sciadopilysin, tetrahydrogamboic acid, TAM-11, LY 235959, CGS 19755, SK&F 97541, etidronic acid, levonordefrin, methyldopa, ampicillin trihydrate, D-aspartic acid, gamma-D-glutamylaminomethylsulfonic acid, phenazopyridine to hydrochloride, oxalamine citrate salt, podophyllotoxin, SK&F 97541, (+-)-4-amino-3-(5-chloro-2-thienyl)-butanoic acid, (RS)-(tetrazol-5-yl) glycine, R(+)-SKF-81297, gambogic acid, and derivatives thereof.Type: ApplicationFiled: July 23, 2009Publication date: March 25, 2010Inventors: Li-Huei Tsai, Stephen J. Haggarty, Dohoon Kim
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Patent number: 7683194Abstract: The invention relates to a method for the production of salts of weakly coordinating anions of the type according to the following formula (1), (2) or (3): M[F—X(OR F)m]z (1), M[(FRO)mX—F—X(ORF)m]z (2), M[(FRO)mX—F—X(ORF)n—F—X(ORF)m]z (3), these salts of weakly coordinating anions and use thereof.Type: GrantFiled: October 28, 2004Date of Patent: March 23, 2010Assignee: Universitat FreiburgInventors: Ingo Krossing, Marcin Gonsior, Lutz Muller
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Patent number: 7674937Abstract: This invention is directed to a class of compounds that can be both monodentate and bidentate in their association with a transition metal to form a catalyst for reactions such as the hydroformylation of olefins to produce aldehydes. The compounds contain two phosphorus atoms having different steric and/or electronic nature. In hydroformylation catalysts, the compounds advantageously can produce a variable n/iso product mixture of aldehyde products that can be varied by simply changing process variables such as [H2]/[CO] partial pressure gas ratio or temperature/inert gas partial pressure.Type: GrantFiled: May 28, 2008Date of Patent: March 9, 2010Assignee: Eastman Chemical CompanyInventors: Ginette Struck Tolleson, Thomas Allen Puckette
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Publication number: 20100041016Abstract: The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. Such compounds may comprise phosphates permitting the detection of phosphatases. The present disclosure can also be used to measure enzyme-kinetics.Type: ApplicationFiled: February 17, 2009Publication date: February 18, 2010Inventors: Neal Arthur Siegel, Samar Kumar Kundu, Charles Lester Ginsburgh
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Publication number: 20100016585Abstract: The Phosphorus-containing bisphenols and preparing method thereof are disclosed. A method for producing the phosphorus-containing bisphenol of the general formula (1) includes reacting compounds respectively defined by a general formula (a), (b), (c) and an acid catalyst to yield compounds of phosphorus-containing bisphenol.Type: ApplicationFiled: July 14, 2009Publication date: January 21, 2010Applicants: NATIONAL CHUNGHSING UNIVERSITY, CHANG CHUN PLASTICS CO., LTDInventors: Ching-Hsuan LIN, Chia-Wei CHANG, Tsung-Li LIN, Kuen-Yuan HWANG, An-Pang TU, Fang-Hsien SU
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Publication number: 20100004363Abstract: A composition is disclosed that comprises a blend of at least two different phosphites of the structure wherein R1, R2, and R3 are independently selected alkylated aryl groups and wherein said blend is a liquid at ambient conditions. The compositions are useful for stabilizing thermoplastic resins and elastomers.Type: ApplicationFiled: July 31, 2009Publication date: January 7, 2010Applicant: Chemtura CorporationInventors: Michael E. Gelbin, Maurice Power, Jonathan S. Hill
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Publication number: 20100004440Abstract: The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.Type: ApplicationFiled: September 9, 2009Publication date: January 7, 2010Inventors: Dong-Gyu CHO, Jae-Hong LIM, Jae-Taeg HWANG, Woo-Young CHO, Hyun-Sook JANG, Chang-Ho LEE, Tae-Saeng CHOI, Chung-Mi KIM, Yong-Zu KIM, Tae-Kyun KIM, Seung-Joo CHO, Gyoung-Won KIM, Jong-Ryoo CHOI, Jeong-Min KIM, Kee-Yoon ROH
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Publication number: 20090292135Abstract: The invention relates to chemical genera of organometal benzenephosphonates useful in cross-coupling organic synthesis, having general formula: where R is selected from boron, zinc, tin and silicon residues.Type: ApplicationFiled: May 9, 2006Publication date: November 26, 2009Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Timothy C. Barden, Peter Lee, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley, JingJing Yang
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Publication number: 20090286885Abstract: A composition comprising a compound of formula (I) or (II): (A)w-P(O)(O?M+)3-w ??(I) or wherein A is Rf—(CH2)k?[(CF2CF)y—(CH2CH2)z]mO and contains from about 8 to about 22 carbon atoms; Rf is CnF2n+1; n and k are each independently 1 to about 6; y, z, and m are each independently 1, 2, 3, or mixture thereof; w is 1 or 2 or a mixture thereof; and M is hydrogen, ammonium ion, an alkali metal ion, or an alkanolammonium ion.Type: ApplicationFiled: May 19, 2008Publication date: November 19, 2009Applicant: E.I. du Pont de Nemuours and CompanyInventors: Weiming Qiu, Xiuling Shirley Wang
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Publication number: 20090281356Abstract: Method of producing compounds of the general formula XPR2(OR1)??I a where X is chlorine, bromine or iodine and R1 is an organic radical, by reacting compounds of the general formula X2PR2??II, in which X has the meaning given above and R2 is an organic radical, with compounds of the general formula R1OH??III, in which R1 has the meaning given above, to give a mixture IV, in that a) the postreaction is carried out at a temperature of from 50 to 240° C. and a pressure of from 0.001 to 0.9 bar, b) from the mixture IV the compounds I a are separated off from the compounds PR2(OR1)2??I b and, if appropriate, the compounds II and c) compounds I b and, if appropriate, unreacted compounds II are returned to the synthesis stage.Type: ApplicationFiled: July 3, 2007Publication date: November 12, 2009Applicant: BASF SEInventors: Robert Baumann, Tobias Aechtner, Wolfgang Siegel, Hermann Luyken, Peter Pfab, Jens Scheidel, Andreas Leitner, Andreas Glass
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Publication number: 20090275782Abstract: Cadmium selenide, and other quantum dot materials, can be integrated into thin films of poly(para-phenylene vinylene) (PPV) or other polymer compounds without aggregation of the nanocrystals. Solid-state photoluminescence spectra of composite materials prepared by these novel techniques reveal the effect of this greatly enhanced quantum dot-polymer interface relative to cases where the nanoparticles are aggregated, such that electronic communication and energy transfer between the nanoparticle and polymer components is made more efficient.Type: ApplicationFiled: April 27, 2009Publication date: November 5, 2009Inventors: Todd S. Emrick, Habib Skaff, Kevin Sill