Benzene Ring Containing Patents (Class 568/306)
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Publication number: 20110124859Abstract: The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.Type: ApplicationFiled: February 7, 2011Publication date: May 26, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Thomas KRUEGER, Uwe RIES, Juergen SCHNAUBELT, Werner RALL, Zeno A. LEUTER, Adil DURAN, Rainer SOYKA
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Patent number: 7935847Abstract: C-nitroso compound releases nitroxyl ion in blood in a second order reaction.Type: GrantFiled: April 16, 2008Date of Patent: May 3, 2011Assignee: Duke UniversityInventors: Eric J. Toone, David M. Gooden
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Publication number: 20110087013Abstract: The present invention concerns a synthesis process comprising the following steps (i) reacting 3-ethyl-4-nitrobenzoic acid with thionyl chloride to produce a 3-ethyl-4-nitrobenzoic acid chloride or a 3-ethyl-4-nitrobenzoic acid anhydride from 3-ethyl-4-nitrobenzoic acid by means of water cleavage and (ii) Friedel-Crafts acylation by reacting the 3-ethyl-4-nitrobenzoic acid chloride or the 3-ethyl-4-nitrobenzoic acid anhydride with an optionally substituted aryl-H to form an optionally substituted (3-ethyl-4-nitrophenyl)-aryl-methanone. In addition the present invention concerns compounds containing (3-ethyl-4-nitrophenyl)-aryl-methanone, characterized in that the optionally substituted aryl is an optionally substituted condensed aromate.Type: ApplicationFiled: October 5, 2010Publication date: April 14, 2011Inventor: Bernhard Knipp
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Publication number: 20110082295Abstract: To develop a highly safe measure to treat Alzheimer's disease using a secretase-inhibiting substance, there is provided a compound represented by the following general formula (I) or a salt thereof: wherein A represents a phenyl group or the like, R1 represents a chlorine atom, a bromine atom, or a nitro group or the like, R2, R3, R4, and R5 each represent a hydrogen atom or the like, and L represents CH2—CH2 or CH?CH.Type: ApplicationFiled: May 27, 2009Publication date: April 7, 2011Applicants: Tokyo Institute of Technology, Kyoto UniversityInventors: Hachiro Sugimoto, Takashi Takahashi, Ichiro Hijikuro, Michiaki Okuda
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Publication number: 20110039701Abstract: The invention relates to novel compounds of the formula (I) in which X, Y, Z, A, B and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the phenyl-substituted bicyclooctane-1,3-dione derivates 33 and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or acaricides and/or for preventing unwanted plant growth.Type: ApplicationFiled: March 30, 2010Publication date: February 17, 2011Applicant: Bayer CropScience AGInventors: Alfred ANGERMANN, Guido Bojack, Reiner Fischer, Stefan Lehr, Jan Dittgen, Dieter Feucht, Isolde Häuser-Hahn, Christopher Hugh Rosinger, Arnd Voerste
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Publication number: 20110034654Abstract: A chiral polymer organocatalyst comprising a main chain and side chain organocatalytic groups covalently attached to the main chain, which organocatalytic groups comprise an amino acid or amino acid derivative of the following general formula (I), in which one stereoisomeric form predominates: formula (I) wherein the catalyst is bound to the polymer main chain via R1, R2, R4, R5 or R6 through a linker (L) or direct bond, and wherein R1-R6 and Z are defined as follows: R1 is H, a naturally occurring alpha-amino acid side chain or a non-natural commercially available alpha-amino acid side chain that may contain L; R2 is H, O (doubly bonded to give a carbonyl), O-L (where L is a linker), NH-L or L; R3 is H or doubly bonded to give a carbonyl with R2 when R2 is O; R4 is H, C1-C6 alkyl or L R5 is H, CO2H, C1-C6 alkyl, benzyl, L, CONHR (in which R is alkyl, aryl, heteroaryl, arylalkyl or, heteroarylalkyl), tetrazolyl, CH2 coupled to a triazole moiety, an esterified CH2OH or CO2R (in which R is alkyl, aryl, heteroarType: ApplicationFiled: January 7, 2009Publication date: February 10, 2011Inventors: Tore Hansen, Finn Knut Hansen, Tor Erik Kristensen
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Patent number: 7862996Abstract: Protective groups which may be cleaved with an activatable deprotecting reagent are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.Type: GrantFiled: December 28, 2006Date of Patent: January 4, 2011Assignee: Affymetrix, Inc.Inventors: Robert G. Kuimelis, Glenn H. McGall, Martin J. Goldberg, Guangyu Xu
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Patent number: 7858399Abstract: The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophilic attack; reacting the activated benzoic acid derivative with a polyamine to produce the benzoic acid derivative of Formula 3: and binding the benzoic acid derivative of Formula 3 to a latex polymer having functional groups that react with aliphatic amino groups. A method of conducting an immunoassay using the immobilized procainamide analog Formula 3 is described, comprising the steps of preparing a solution comprising said immobilized procainamide analog; adding a sample suspected of containing procainamide to said solution; adding an anti-procainamide antibody to said solution and observing the rate of increase in solution turbidity following antibody addition.Type: GrantFiled: August 28, 2007Date of Patent: December 28, 2010Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Victor P. Chu, Zhu Teng, Steve P. A. Goss, Ronald A. Edwards, Kelle M. Garvey, Timothy J. Gorzynski, William D. Bedzyk
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Publication number: 20100305095Abstract: The present invention relates to, inter alia, the use of a compound capable of inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD) in an animal in the manufacture of a medicament for use in the treatment and/or prevention of depression. The invention also provides for the use of a compound capable of inhibiting HPPD in an animal in the manufacture of a medicament for use in the treatment of the withdrawal symptoms associated with an addictive drug which causes dopamine dependant associative learning disorders in said animal. In a particular embodiment said HPPD inhibitor is selected from the group consisting of the compound depicted as compound 1; 2; and 3.22.Type: ApplicationFiled: August 18, 2006Publication date: December 2, 2010Inventors: Kim Zachary Travis, John Posner
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Patent number: 7820681Abstract: Methods for concomitant administration of colchicine together with one or more second active agents, e.g., ketoconazole and ritonavir, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.Type: GrantFiled: February 17, 2009Date of Patent: October 26, 2010Assignee: Mutual Pharmaceutical Company, Inc.Inventor: Matthew W. Davis
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Publication number: 20100249243Abstract: This invention relates to ?-hydroxyketones and ?-alkoxyketones of formula (I), to their use as estrogen receptor modulators, and to methods for their preparation.Type: ApplicationFiled: November 21, 2008Publication date: September 30, 2010Inventors: Juha Pulkkinen, Paavo Honkakoski, Mikael Peräkylä, Istvan Berczi, Reino Laatikainen
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Patent number: 7795258Abstract: A pyridazine compound represented by formula (1): wherein R1 and R2 are same or different and represent a C1-C4 alkyl group; R3 represents a halogen atom, a nitro group, a cyano group, a C1-C4 alkyl group optionally substituted by at least one halogen atom, a C1-C4 alkoxy group optionally substituted by at least one halogen atom or a C1-C4 alkylthio group optionally substituted by at least one halogen atom; R4 and R5 each represents a halogen atom, a nitro group, a cyano group, a C1-C4 alkyl group optionally substituted by at least one halogen atom or a C1-C4 alkoxy group optionally substituted by at least one halogen atom; and m and n each represents an integer.Type: GrantFiled: June 2, 2005Date of Patent: September 14, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroshi Morishita, Akio Manabe
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Publication number: 20100204482Abstract: The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by the groups R6, R7 and R8; R1 is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4alkoxy, C1-4haloalkoxy, CH2C?CR9, CH2CR10?CHR11, CH?C?CH2 or COR12; R2 and R3 are each, independently, hydrogen, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl or C1-4 haloalkoxy; R4 and R5 are each independently selected from halo, cyano and nitro; or one of R4 and R5 is hydrogen and the other is selected from halo, cyano and nitro; R6, R7 and R8 are each, independently, hydrogen, halo, cyano, nitro, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy(C1-4)alkyl, C1-4haloalkoxy(C1-4)alkyl or C1-4haloalkoxy, provided that at least one of R6, R7 and R8 is not hydrogen; R9, R10 and R11 are each, independently, hydrogen, halo, C1-4 alkyl, C1-4 haloalkyl or C1-4 alkoxy(C1-4)alkyl; and R12 is hydrogen,Type: ApplicationFiled: April 23, 2010Publication date: August 12, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Hans Tobler, Harald Walter, Josef Ehrenfreund, Camilla Corsi
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Publication number: 20100184986Abstract: Organocatalysts, particularly proline sulfonamide organocatalysts, having a first general formula as follows are disclosed. Embodiments of a method for using these organocatalysts also are disclosed. The method comprises providing a disclosed organocatalyst, and performing a reaction, often an enantioselective or diastereoselective reaction, using the organocatalyst. Solely by way of example, disclosed catalysts can be used to perform aldol reactions, conjugate additions, Michael additions, Robinson annulations, Mannich reactions, ?-aminooxylations, ?-hydroxyaminations, ?-aminations and alkylation reactions. Certain of such reactions are intramolecular cyclizations used to form cyclic compounds, such as 5- or 6-membered rings, having one or more chiral centers. Disclosed organocatalysts generally are much more soluble in typical solvents used for organic synthesis than are known compounds.Type: ApplicationFiled: March 17, 2010Publication date: July 22, 2010Inventors: Rich Garrett Carter, Hua Yang
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Publication number: 20100160295Abstract: Methods of preventing and/or treating at least one symptom of Restless Leg Syndrome (RLS) and its related disorders, including disorders such as periodic limb movements in sleep (PLMS) and periodic limb movement disorder (PLMD), are disclosed. The methods comprise identifying a host, afflicted with Restless Leg Syndrome (RLS) and its related disorders; and administering to the host a pharmaceutically effective amount of a 4-hydroxyphenylpyruvate dioxygenase. Also provided are methods and compositions for treating/preventing sleep disorders, and methods and compositions for improving sleep quantity and adequacy.Type: ApplicationFiled: November 6, 2009Publication date: June 24, 2010Applicant: SYNOSIA THERAPEUTICSInventors: Lesley PICKFORD, Uwe Meya, Mark Moran
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Patent number: 7718145Abstract: A polyisocyanate production system is provided that can stably produce chlorine from hydrogen chloride produced secondarily while reacting stably between carbonyl chloride and polyamine and can perform an effective treatment of the hydrochloric gas produced secondarily. A hydrochloric gas control unit 32 controls a flow-rate control valve 23 to keep constant an amount of hydrogen chloride supplied from a hydrogen chloride purifying tank 4 to a hydrogen chloride oxidation reactor 6 via a second hydrochloric-gas connection line 11 to be constant, and also controls a pressure control valve 22 based on an inner pressure of the hydrogen chloride purifying tank 4 input from a pressure sensor 25 to discharge the hydrochloric gas from the hydrogen chloride purifying tank 4 to the hydrogen chloride absorbing column 5 via a first hydrochloric-gas connection line 10, so as to keep an inner pressure of the hydrogen chloride purifying tank 4 to be constant.Type: GrantFiled: March 17, 2006Date of Patent: May 18, 2010Assignee: Mitsui Chemicals, Inc.Inventors: Masaaki Sasaki, Hirofumi Takahashi, Kouji Maeba, Takao Naito, Kouichirou Terada, Takashi Yamaguchi, Takuya Saeki
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Publication number: 20100094060Abstract: C-nitroso compound releases nitroxyl ion in blood in a second order reaction.Type: ApplicationFiled: April 16, 2008Publication date: April 15, 2010Applicant: Duke UniversityInventors: Eric Toone, David M. Gooden
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Publication number: 20100029588Abstract: The present invention relates to oxime ether-, hydrazone- or azomethine-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the amidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.Type: ApplicationFiled: March 8, 2008Publication date: February 4, 2010Applicant: BAYER CROPSCIENCE AGInventors: Thomas Seitz, Klaus Kunz, Wahed Ahmed Moradi, Jörg Nico Greul, Darren James Mansfield, Urlich Heinemann, Amos Mattes, Oswald Ort, Jean-Pierre Vors, Peter Dahem, Ulrike Wachendorff-Neumann, Arnd Voerste
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Publication number: 20090326072Abstract: The present invention relates to, inter alia, the use of 2-(2-Nitro-4-Trifluoromethylbenzoyl)-1,3-Cyclohexanedione (compound 2) in the treatment of a neurodegenerative disease, such as Parkinson's disease. The invention also relates to the use of the compound depicted as compound 2 or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of a neurodegenerative disease such as Parkinson's disease.Type: ApplicationFiled: February 27, 2006Publication date: December 31, 2009Inventors: John Ernest Doe, Nicholas Crispinian Sturgess, Kim Zachary Travis
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Patent number: 7619004Abstract: Methods for concomitant administration of colchicine together with one or more macrolide antibiotics, e.g., clarithromycin or erythromycin, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for co-administration of colchicine together with macrolide antibiotics are also provided.Type: GrantFiled: December 3, 2008Date of Patent: November 17, 2009Assignee: Mutual Pharmaceutical Company, Inc.Inventor: Matthew W. Davis
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Patent number: 7608740Abstract: The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skeleton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.Type: GrantFiled: September 27, 2005Date of Patent: October 27, 2009Assignee: Avra Laboratories Pvt. LtdInventors: Ramakrishna Rao, Venkata Rama Rao Alla
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Patent number: 7601758Abstract: Methods for treating gout flares comprising concomitant administration of colchicine together with one or more macrolide antibiotics, e.g., clarithromycin or erythromycin, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for co-administration of colchicine together with macrolide antibiotics are also provided.Type: GrantFiled: February 10, 2009Date of Patent: October 13, 2009Assignee: Mutual Pharmaceutical Company, Inc.Inventor: Matthew W. Davis
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Patent number: 7598289Abstract: The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, Ralk, —ORO, and -Q are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and/or activity, and inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.Type: GrantFiled: August 19, 2008Date of Patent: October 6, 2009Assignee: The University Court of the University of AberdeenInventors: Stuart H. Ralston, Iain R. Greig, Aymen I. I. Mohamed, Robert J. Van 'T Hof
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Patent number: 7589123Abstract: Compounds of general formula I: wherein: R1 and R2 are, independently of each other, selected from hydrogen, optionally substituted C1-10alkyl, optionally substituted —CO—(C1-10alkyl), optionally substituted C3-10cycloalkyl, optionally substituted —CO—(C3-10cycloalkyl), optionally substituted C2-10alkenyl, optionally substituted —CO—(C2-10alkenyl), optionally substituted aryl, and optionally substituted —CO-aryl, or R1 and R2 together represent an optionally substituted saturated or unsaturated C1-10alkylidene group, or an optionally substituted saturated or unsaturated C3-10cycloalkylidene group, or R1 and R2 together with the carbon atom to which they are attached represent an optionally substituted saturated or unsaturated organic ring containing 3, 4, 5, 6, 7 or 8 ring carbon atoms and optionally 1, 2 or 3 ring heteroatoms selected from O, N and S; R3, which may be the same as, or different from, either of R1 and R2, is selected from optionally substituted C1-10alkyl, optionally substituted C3-10cyclType: GrantFiled: July 5, 2007Date of Patent: September 15, 2009Assignee: Phytopharm PLCInventors: Daryl David Rees, Phillip James Gunning, Antonia Orsi, Patrick A. Howson, Paul Barraclough, Noelle Callizot
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Patent number: 7563789Abstract: The present invention relates to the compounds of the general formula (I), a composition for and a method of treating breast cancer or other proliferative disorders in a subject using a compound of general formula [I], wherein the substituents are as defined in the specification.Type: GrantFiled: April 7, 2006Date of Patent: July 21, 2009Inventors: Gloria Long Anderson, Tawfeq Abdul-Raheem Kaimari
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Publication number: 20090163741Abstract: This invention is directed to a method of performing a stereoselective reaction without use of a solvent comprising contacting a reactant with a chiral reagent under sonication conditions to form an excess of an enantiomer.Type: ApplicationFiled: December 19, 2008Publication date: June 25, 2009Inventors: Matthew P. Meyer, Hui Zhu
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Publication number: 20090076113Abstract: Novel biphenylcarboxamides of the formula (I) There is further provided a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms, and also novel intermediates and their preparation.Type: ApplicationFiled: December 5, 2006Publication date: March 19, 2009Applicant: Bayer CropScience AGInventors: Ralf Dunkel, Hans-Ludwig Elbe, Jorg Nico Greul, Herbert Gayer, Arnd Voerste, Ulrike Wachendorff-Neumann, Peter Dahmen
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Patent number: 7452673Abstract: Compounds represented by the following structural formulas can be used as photoacid generators: Such compounds are useful, for example, in fabricating arrays of polymers.Type: GrantFiled: January 16, 2007Date of Patent: November 18, 2008Assignee: Affymetrix, Inc.Inventors: Glenn H. McGall, Andrea Cupoletti
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Publication number: 20080275100Abstract: The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.Type: ApplicationFiled: July 9, 2008Publication date: November 6, 2008Applicant: ABRAXIS BIOSCIENCE, INC.Inventors: Chunlin TAO, Cheng Zhi YU, Neil P. DESAI, Vuong TRIEU
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Patent number: 7439366Abstract: The present invention relates to a phenacylamine derivative of the formula (I) or a salt thereof: wherein A is alkyl, cycloalkyl, phenyl which may be substituted by Y, pyridyl which may be substituted by Y, or pyrazolyl which may be substituted by Y, R1 and R2 are each alkyl, or R1 and R2 may together form a 3- to 6-membered saturated carbocycle, R3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl or COR4, X is halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkylthio, haloalkylthio, alkenylthio, haloalkenylthio, alkynylthio, haloalkynylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, nitro, cyano, phenyl which may be substituted by Y, phenoxy which may be substituted by Y, benzyloxy which may be substituted by Y, or pyridyloxy which may be substituted by Y, and n is an integer of from 0 to 5.Type: GrantFiled: February 9, 2001Date of Patent: October 21, 2008Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Yuji Nakamura, Masayuki Morita, Kenji Izakura
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Publication number: 20080221358Abstract: The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skeleton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.Type: ApplicationFiled: September 27, 2005Publication date: September 11, 2008Inventors: Ramakrishna Rao, Venkata Rama Rao Alla
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Publication number: 20080161391Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: ApplicationFiled: February 13, 2008Publication date: July 3, 2008Applicants: The University of North Carolina, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Publication number: 20080154066Abstract: A polyisocyanate production method that can allow effective use of hydrogen chloride produced secondarily in a polyisocyanate production process, while allowing reduction of environmental burdens, and a polyisocyanate production system for performing the polyisocyanate production method. After chlorine is allowed to react with carbon monoxide to produce carbonyl chloride in a carbonyl chloride producing reactor, the carbonyl chloride produced in the carbonyl chloride producing reactor is allowed to react with polyamine in an isocyanate producing reactor to produce polyisocyanate. Then, after hydrochloric gas produced secondarily in the isocyanate producing reactor is purified in a hydrogen chloride purifying column, the purified hydrochloric gas is oxidized in a hydrogen chloride oxidizing reactor to produce chlorine.Type: ApplicationFiled: March 8, 2006Publication date: June 26, 2008Applicant: Mitsui Chemicals Polyurethanes, IncInventors: Masaaki Sasaki, Takao Naito, Fumiaki Hirata, Masato Saruwatari, Hirofumi Takahashi, Kouji Maeba, Tsugio Imaizumi, Takuya Saeki, Takashi Yamaguchi, Kouichirou Terada
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Publication number: 20080146660Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.Type: ApplicationFiled: February 13, 2008Publication date: June 19, 2008Applicants: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience CorporationInventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
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Patent number: 7368608Abstract: An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisting of saturated or unsaturated C1-4 alkyl group, aralkyl group in which alkyl moiety has 1 to 4 carbon atoms, aryl group, halogen atom, halogenated C1-4 alkyl group, C2-5 alkanoyl group, mono or dialkylcarbamoyl group in which alkyl moiety has 1 to 4 carbon atoms, cyano group and nitro group, and the substituents at positions 3 and 6, or at positions 4 and 5 on the cycle A are different each other. Other ring may be fused at positions 3 and 4, or at positions 5 and 6 on the cycle A to form a condensed polycyclic hydrocarbon with the cycle A. R1 is alkanoyl group or aroyl group, and R2 is hydrogen atom, alkanoyl group or aroyl group, or R1 and R2 may be combined together with the N atom to form a cyclic imido group, which is useful as an intermediate of medicines, etc.Type: GrantFiled: July 19, 2005Date of Patent: May 6, 2008Assignee: Daiso Co., Ltd.Inventors: Yasushi Miki, Masafumi Mikami
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Publication number: 20080103240Abstract: The invention is based on the discovery that the compounds and compositions described herein are useful as film-forming adhesives for use in a variety of applications, including, for example, adhesive tapes for the electronic packaging industry. The invention compositions described herein can be cured in a variety of ways with or without a catalyst.Type: ApplicationFiled: November 1, 2006Publication date: May 1, 2008Inventor: Stephen M. Dershem
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Patent number: 7335687Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.Type: GrantFiled: December 15, 2004Date of Patent: February 26, 2008Assignee: Hoffmann-La Roche Inc.Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
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Patent number: 7279340Abstract: The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophilic attack; reacting the activated benzoic acid derivative with a polyamine to produce the benzoic acid derivative of Formula 3: and binding the benzoic acid derivative of Formula 3 to a latex polymer having functional groups that react with aliphatic amino groups. A method of conducting an immunoassay using the immobilized procainamide analog Formula 3 is described, comprising the steps of preparing a solution comprising said immobilized procainamide analog; adding a sample suspected of containing procainamide to said solution; adding an anti-procainamide antibody to said solution and observing the rate of increase in solution turbidity following antibody addition.Type: GrantFiled: April 7, 2004Date of Patent: October 9, 2007Assignee: Dade Behring Inc.Inventors: Victor P. Chu, Zhu Teng, Steve P. A. Goss, Ronald L. Edwards, Kelle M. Garvey, Timothy J. Gorzynski, William D. Bedzyk
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Patent number: 7160887Abstract: Compounds of a formula: wherein Ring A represents an optionally-substituted aromatic ring; Ring B represents an optionally-substituted cyclic hydrocarbon group; Z represents an optionally-substituted cyclic group; R1 represents a hydrogen atom, an optionally-substituted hydrocarbon group, an optionally-substituted heterocyclic group, or an acyl group; R2 represents an optionally-substituted amino group; D represents a chemical bond or a divalent group; E represents —CO—, —CON(Ra)—, COO—, N(Ra)CON(Rb)—, —N(Ra)COO—, —N(Ra)SO2—, N(Ra)—, —O—, —S—, —SO— or —SO2— (in which Ra and Rb each independently represent a hydrogen atom or an optionally-substituted hydrocarbon group); G represents a chemical bond or a divalent group; L represents (1) a chemical bond or (2) a divalent hydrocarbon group optionally having from 1 to 5 substituents selected from; (i) a C1-6 alkyl group, (ii) a halogeno-C1-6 alkyl group, (iii) a phenyl group, (iv) a benzyl group, (v) an optionally-substituted amino group, (vi) an optionallyType: GrantFiled: October 19, 1999Date of Patent: January 9, 2007Assignee: Takeda Pharmaceutical Company LimitedInventors: Satoru Oi, Nobuhiro Suzuki, Kazuyoshi Aso, Yoshihiro Banno
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Patent number: 7041853Abstract: It is an object of the present invention to provide a process for producing highly pure 4-bromothioanisole, which is useful in the manufacture of medicinal chemicals, agrochemicals or functional materials, in a simple and industrially advantageous manner. The present invention is related to a process for producing 4-bromothioanisole which comprises adding an alcoholic solvent to a 4-bromothioanisole-containing product resulting from the reaction of thioanisole with bromine to cause crystallization of 4-bromothioanisole.Type: GrantFiled: March 21, 2001Date of Patent: May 9, 2006Assignee: Sumitomo Seika Chemicals Co., Ltd.Inventors: Kenichi Wakimura, Hitoshi Karino, Hirokazu Kagano
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Patent number: 6951963Abstract: The invention provides processes for preparing N-protected ?-amino aldehyde compounds which are useful as synthetic intermediates for preparing glycopeptide antibiotic derivatives. The processes include cleaving a carbon-carbon double bond to form the N-protected ?-amino aldehyde compound.Type: GrantFiled: June 16, 2003Date of Patent: October 4, 2005Assignee: Theravance, Inc.Inventors: Junning Lee, Jyanwei Liu
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Patent number: 6858651Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.Type: GrantFiled: August 9, 2001Date of Patent: February 22, 2005Assignee: Hoffmann-La Roche Inc.Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
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Patent number: 6855696Abstract: The present invention provides illudin analogs of the general formula I: wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I, intermediates and processes useful for preparing compounds of formula I, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I.Type: GrantFiled: November 5, 2001Date of Patent: February 15, 2005Assignee: The Regents of the University of CaliforniaInventors: Trevor C. McMorris, Michael J. Kelner
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Publication number: 20040122260Abstract: The present invention is an improved process for preparing 2-nitro-4′-fluorobenzophenone which comprises contacting 2-nitrobenzoyl chloride and fluorobenzene in a reaction medium the presence of anhydrous ferric chloride. The process is typically performed at a temperature of about −20° C. to about 25° C.Type: ApplicationFiled: December 20, 2002Publication date: June 24, 2004Inventor: Robert Joseph Maleski
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Patent number: 6680385Abstract: A method for the preparation of aryl methyl ketones converts a variety of ethyl arenas to the corresponding aryl methyl ketones using a dioxygen-containing gas as the oxidant. The catalyst used for the reaction is a metal complex bearing general formulas as disclosed.Type: GrantFiled: January 25, 2002Date of Patent: January 20, 2004Assignees: The Hong Kong Polytechnic University, Sichuan UniversityInventors: Albert Sun-Chi Chan, Jian-Ying Qi, Cheng-Chao Pai, Xian-Jun Li, Li-Sheng Deng, Wen-Zao Li, Bin Sun, Jia-Yuan Hu
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Publication number: 20030229252Abstract: The present invention relates to a process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate, in which 4-(2-nitrophenyl)-n-butyronitrile is converted to 4-(2-nitrophenyl)-n-butyric acid.Type: ApplicationFiled: May 28, 2003Publication date: December 11, 2003Inventors: Joachim Zechlin, Kai Verkerk, Dietmar Wastian, Katrin Joschek, Tim Loddenkemper, Wilfried Pinke, Michael Schelhaas, Georg Ronge
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Publication number: 20030199707Abstract: Provided are processes for the preparation of the compound of the formula 1Type: ApplicationFiled: April 25, 2003Publication date: October 23, 2003Applicant: Onconova Therapeutics, Inc.Inventors: M. V. Ramana Reddy, Stanley C. Bell
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Publication number: 20030171422Abstract: The present invention relates to the compounds of formula: 1Type: ApplicationFiled: February 12, 2003Publication date: September 11, 2003Applicant: Merck Patent GmbHInventors: Claude Lardy, Jaques Barbanton, Herve Dumas, Francois Collonges, Phillppe Durbin
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Patent number: 6608233Abstract: The present invention relates to a process for producing a bis(4-hydroxy-3-nitrophenyl) compounds, characterized by nitrating a bis(4-hydroxyphenyl) compound wherein two phenyl groups are bonded to each other directly or through an electron-donating bridging group, sulfoxide group, sulfone group or carbonyl group in an inert solvent using nitric acid under the condition of substantially free from any other acid. According to the process, the target compounds reduced in the content of trinitrates can be produced in high yield and further recrystallizing the compound easily gives in high yield a high-purity products suitable for use as a raw material of producing a heat-resistant polymer and so on because the content of a trinitro-substitued compound in that compound is low.Type: GrantFiled: October 10, 2002Date of Patent: August 19, 2003Assignee: Nippon Kayaku Kabushiki KaishaInventors: Eiichi Tanaka, Masaki Fujimoto
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Patent number: RE38796Abstract: Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-amino-3-oxo-2-halogenobutanoic acid ester derivative, and hydrolysis and decarboxylation are conducted to produce a 3-amino-2-oxo-1-halogenopropane derivative or its salt. The present method is a useful process for producing a 3-amino-2-oxo-1-halogenopropane derivatives which can easily be converted to a 3-amino-1,2-epoxypropane.Type: GrantFiled: June 16, 2000Date of Patent: September 13, 2005Assignee: Ajinomoto Co.,Inc.Inventors: Yutaka Honda, Satoshi Katayama, Kunisuke Izawa, Masakazu Nakazawa, Takayuki Suzuki, Naoko Kanno