Carbonyl Or Oxy Containing (e.g., Ketone Containing, Etc.) Patents (Class 568/37)
  • Patent number: 9574122
    Abstract: There is provided a method for reducing the content of at least one water soluble volatile organic compound in a gas. The method comprises contacting the gas with an aqueous acidic oxidizing composition comprising H2O2 and a metal catalyst, and submitting the at least one water soluble volatile organic compound and the aqueous acidic oxidizing composition to an UV radiation.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: February 21, 2017
    Assignees: Uniboard Canada Inc., EXP Services Inc.
    Inventors: Pierre-André Gignac, Martin Beaulieu, Yves Charest, Stéphane Chabot, Abderrahman Mahfoud, Jules Lemay
  • Patent number: 9056817
    Abstract: The invention discloses a one pot process for the arylation of ?-dicarbonyl compounds. Particularly, the present invention discloses transition-metal-free, chemo-selective, one pot process for the C-arylation of malonamide esters having Formula I at room temperature provide temperature range to obtain the arylated compounds of formula II with good yield, wherein the arylated compounds are selected from mono-arylated compound and di-arylated compound or mixture thereof.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: June 16, 2015
    Assignee: Council of Scientific and Industrial Research
    Inventors: Mhaske Baburao Santosh, Ranjeet Ashokrao Dhokale, Pramod Rameshrao Thakare
  • Patent number: 9012693
    Abstract: Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: April 21, 2015
    Assignee: Kappa Bioscience AS
    Inventors: Lars Skattebol, Inger Reidun Aukrust, Marcel Sandberg
  • Patent number: 8993768
    Abstract: Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment or prevention of infection by human immunodeficiency virus (HIV).
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: March 31, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Beutler, Stuart F. J. LeGrice, Craig Thomas, Jian-Kang Jiang, Suhman Chung, Jennifer Wilson
  • Publication number: 20150087833
    Abstract: An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.
    Type: Application
    Filed: April 11, 2013
    Publication date: March 26, 2015
    Applicants: IHARA CHEMICAL INDUSTRY CO., LTD., KUMIAI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Kei Domon, Keiji Toriyabe, Yutaka Ogawa, Junichiro Bessho, Kei Kawamoto, Akira Watanabe, Masaaki Komatsu, Takeshi Matsuda, Seisuke Ito
  • Publication number: 20150044839
    Abstract: A photoresist stripping and cleaning composition free from N-alkylpyrrolidones and added quaternary ammonium hydroxides comprising a component (A) which comprises the polar organic solvents N-methylimidazole, dimethylsulfoxide and 1-aminopropane-2-ol.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 12, 2015
    Applicant: BASF SE
    Inventors: Simon Braun, Christian Bittner, Andreas Klipp
  • Publication number: 20140249181
    Abstract: Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment or prevention of infection by human immunodeficiency virus (HIV).
    Type: Application
    Filed: May 10, 2012
    Publication date: September 4, 2014
    Applicant: The united States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: John A. Beutler, Stuart F.J. LeGrice, Craig Thomas, Jian-Kang Jiang, Suhman Chung, Jennifer Wilson
  • Patent number: 8808702
    Abstract: Compounds useful as antiproliferative agents according to formula (I): wherein Ar1, Ar2, Ar3, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: August 19, 2014
    Assignee: Temple University-of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Publication number: 20140228219
    Abstract: The present invention provides a compound having an excellent efficacy for controlling weeds. A cyclohexanone compound of the formula (I): wherein m is an integer of 1, 2 or 3; n is an integer of any one of 1 to 5; X represents CH2, O, S, S(O) or S(O)2; R1 represents a hydrogen atom or a methyl group; R2 and R3 represents a hydrogen atom, a C1-6 alkyl group and the like; R4 represents a C6-10 aryl group or a five- to six-membered heteroaryl group; G represents a hydrogen atom and the like; Z represents a halogen atom, a cyano group, a nitro group, a phenyl group, a C1-6 alkyl group and the like; is useful as an active ingredient for herbicides.
    Type: Application
    Filed: May 29, 2012
    Publication date: August 14, 2014
    Inventors: Yosuke Nakashima, Yoshinobu Jin, Masato Konobe
  • Publication number: 20140205945
    Abstract: To provide a charge controlling agent for electrophotography, which presents sufficient triboelectric chargeability to a toner, is useful particularly for a color toner and further for a polymerized toner, increases a charge rising rate, has a high electric charge amount, is excellent in charging characteristics, stability over time and environmental stability and yet is safe without posing any problem regarding waste regulations, and a negatively chargeable toner for developing an electrostatic image, which uses such a charge controlling agent and which has a high charging performance.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 24, 2014
    Applicant: HODOGAYA CHEMICAL CO., LTD.
    Inventors: Ikuo KIMURA, Masami ITO, Masaya TOJO, Masafumi ASAKAI
  • Patent number: 8722745
    Abstract: The invention relates to a sulfur-containing compound and the preparation thereof. The invention also relates to the uses of the sulfur-containing compound in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2. This invention also describes a series of chemical analogues of the said sulfur-containing compound and the preparation of these compounds.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: May 13, 2014
    Assignee: National Sun Yat-Sen University
    Inventors: Jyh-Horng Sheu, Chih-Hua Chao, Zhi-Hong Wen
  • Patent number: 8580998
    Abstract: Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the derivatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO2-phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: November 12, 2013
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Timothy Edward Long, Sravan Kumar Patel
  • Patent number: 8455657
    Abstract: A process is described for the preparation of 3-alkylsulfinylbenzoyl derivatives of the formula (IIIa) by reaction of 3-alkylsulfinylbenzoic acids of the formula (Ib) with compounds of the formula (II) in the presence of a chlorinating agent and a base. In the formulae specified above, Y is a radical such as pyrazolyl and cyclohexanedionyl. R1, R2 and R3 are radicals such as halogen, nitro, cyano and alkyl.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: June 4, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Mark James Ford, Jan Peter Schmidt, Helmut Kohlhepp
  • Publication number: 20130123514
    Abstract: The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.
    Type: Application
    Filed: May 27, 2011
    Publication date: May 16, 2013
    Applicant: GRAPHEA, INC.
    Inventors: Christopher W. Bielawski, Daniel R. Dreyer, Hong-Peng Jia
  • Patent number: 8399661
    Abstract: The invention relates to a sulfur-containing compound and the preparation thereof. The invention also relates to the uses of the sulfur-containing compound in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2. This invention also describes a series of chemical analogues of the said sulfur-containing compound and the preparation of these compounds.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: March 19, 2013
    Assignee: National Sun Yat-Sen University
    Inventors: Jyh-Horng Sheu, Chih-Hua Chao, Zhi-Hong Wen
  • Publication number: 20130018026
    Abstract: The present invention provides compositions and methods for the targeted delivery, release and/or formation of a drug compound at a target site(s) within the body of an individual, such as a diseased and/or inflamed tissue in the body of the individual. These compositions may comprise a halogenated phenol ring cleavably linked to a core structure of a drug compound. Due to the variety of substituents that may be utilized in forming the different types of linkages, numerous examples of drug compounds linked to a halogenated phenol ring are proposed. The present invention further provides compositions comprising halogenated phenol starting compounds that do not undergo cleavage during a dehalogenation reaction to form a drug compound in a targeted tissue when administered to an individual. Methods of administering these non-cleaving compounds are further provided.
    Type: Application
    Filed: July 13, 2012
    Publication date: January 17, 2013
    Inventor: Keith R. Latham
  • Publication number: 20120184478
    Abstract: The present invention relates to the use of (oxidized) thioethers of polyalkylene oxides in washing and cleaning compositions, especially in dishwashing compositions, and to washing and cleaning compositions, especially dishwashing compositions, which comprise (oxidized) thioethers of alcohol alkoxylates. These (oxidized) thioethers are especially suitable as surfactants with rinse aid function (rinse aid surfactants). “Oxidized” relates to the sulfur atom in the thioether, which may be present in oxidized form as sulfoxide (SO) or sulfonyl (SO2). The invention also relates to particular oxidized thioethers of polyalkylene oxides.
    Type: Application
    Filed: January 13, 2012
    Publication date: July 19, 2012
    Applicant: BASF SE
    Inventors: Sophie Maitro-Vogel, Jürgen Tropsch, Wolfgang Spiegler, Roman Benedikt Raether
  • Publication number: 20120165540
    Abstract: A process is described for the preparation of 3-alkylsulfinylbenzoyl derivatives of the formula (IIIa) by reaction of 3-alkylsulfinylbenzoic acids of the formula (Ib) with compounds of the formula (II) in the presence of a chlorinating agent and a base. In the formulae specified above, Y is a radical such as pyrazolyl and cyclohexanedionyl. R1, R2 and R3 are radicals such as halogen, nitro, cyano and alkyl.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 28, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Mark James FORD, Jan Peter SCHMIDT, Helmut KOHLHEPP
  • Publication number: 20120021902
    Abstract: (4-Trifluoromethyl-3-thiobenzoyl)cyclohexanediones and use thereof as herbicides A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Application
    Filed: July 19, 2011
    Publication date: January 26, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut AHRENS, Andreas VAN ALMSICK, Elmar GATZWEILER, Dieter FEUCHT, Isolde HÄUSER-HAHN, Stefan LEHR, Christopher Hugh ROSINGER
  • Publication number: 20120021904
    Abstract: A description is given of (4-haloalkyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, Y, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Application
    Filed: July 20, 2011
    Publication date: January 26, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut AHRENS, Dieter FEUCHT, Elmar GATZWEILER, Isolde HAUSER-HAHN, Christopher Hugh ROSINGER
  • Patent number: 8058313
    Abstract: ?,?-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: wherein R1, R2, M1, M2, L, E1, E2, Q1, Q2 and n are as defined herein, are useful as anti-angiogenesis agents, as agents for treatment of age related senile dementia, and as antiproliferative agents including, for example, as anticancer agents.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: November 15, 2011
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Publication number: 20110269985
    Abstract: Compounds having stable isotopes 13C and/or 2H were synthesized from precursor compositions having solid phase supports or affinity tags.
    Type: Application
    Filed: June 2, 2011
    Publication date: November 3, 2011
    Applicant: Los Alamos National Security, LLC
    Inventors: Jurgen G. Schmidt, David B. Kimball, Marc A. Alvarez, Robert F. Williams, Rudolfo A. Martinez
  • Patent number: 8043786
    Abstract: The invention provides novel acid generators which are unproblematic in combustibility and accumulation inside the human body and can generate acids having high acidities and high boiling points and exhibiting properly short diffusion lengths in resist coating films and which permit the formation of resist patterns excellent smoothness with little dependence on the denseness of a mask pattern; sulfonic acids generated from the acid generators; sulfonyl halides useful as raw material in the synthesis of the acid generators; and radiation-sensitive resin compositions containing the acid generators. The acid generators have structures represented by the general formula (I), wherein R1 is a monovalent substituent such as alkoxycarbonyl, alkylsulfonyl, or alkoxysulfonyl; R2 to R4 are each hydrogen or alkyl; k is an integer of 0 or above; and n is an integer of 0 to 5.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: October 25, 2011
    Assignee: JSR Corporation
    Inventors: Satoshi Ebata, Yong Wang, Isao Nishimura
  • Patent number: 8017656
    Abstract: A compound given by the formula (I): has an excellent controlling activity against noxious arthropods.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: September 13, 2011
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Miyazaki
  • Patent number: 7947831
    Abstract: Polymers grafted with a compound of formula I, wherein the general symbols are as defined within, have outstanding stability against oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: May 24, 2011
    Assignee: BASF SE Ludwigshafen
    Inventors: Hans-Rudolf Meier, Gerrit Knobloch, Pierre Rota-Graziosi, Samuel Evans, Paul Dubs, Michèle Gerster
  • Patent number: 7943551
    Abstract: What is described are 3-cyclopropyl-4-(3-thiobenzoyl)pyrazoles of the general formula (I) and their use as herbicides In this formula (I), R1, R2, R3, X and Y are radicals such as hydrogen and organic radicals, such as alkyl. R4 is hydrogen or a protective group, such as tosyl.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: May 17, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Andreas van Almsick, Stefan Lehr, Monika Schmitt, Jan Dittgen, Dieter Feucht, Martin Hills, Heinz Kehne, Christopher Rosinger
  • Patent number: 7932242
    Abstract: Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: April 26, 2011
    Assignees: Temple University - Of The Commonwealth System of Higher Education, Onconova Therapeutics Inc.
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stanley C. Bell
  • Publication number: 20100145060
    Abstract: Embodiments of the invention provide a method of using Schwartz Reagent, Cp2Zr(H)Cl, without accumulating or isolating it. Methods provide mixtures of Cp2ZrCl2, reductants that selectively reduce Cp2ZrCl2, and substrates. After reaction of Cp2ZrCl2 and the reductant, an intermediate reduction product is formed, apparently Schwartz Reagent. The in situ Schwartz Reagent then selectively reduces certain functional groups on the substrate. Substrates include tertiary amides, tertiary benzamides, aryl O-carbamates, and heteroaryl N-carbamates, which are reduced to aldehydes, benzaldehydes, aromatic alcohols, and heteroaromatics, respectively. Compared to prior methods, reagents are inexpensive and stable, reaction times are short, and reaction temperature in certain cases is conveniently room temperature. It has been estimated that using the in situ method described herein instead of synthesized or commercially obtained Schwartz Reagent provides a 50% reduction in cost.
    Type: Application
    Filed: December 3, 2009
    Publication date: June 10, 2010
    Inventors: Yigang Zhao, Victor A. Snieckus
  • Publication number: 20100069675
    Abstract: The present invention is directed to the labeled compounds, wherein C* is each either 13C and 12C where at least one C* is 13C, each hydrogen of the methylene group is hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is sulfide, sulfinyl, or sulfone, Z is an aryl group such as 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, or a phenyl group wherein R1, R2, R3, R4 and R5 are each independently either hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group such as NH2, NHR and NRR? where R and R? are each independently either a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.
    Type: Application
    Filed: September 1, 2009
    Publication date: March 18, 2010
    Applicant: Los Alamos National Security, LLC
    Inventors: Rodolfo A. Martinez, Clifford J. Unkefer, Marc A. Alvarez
  • Publication number: 20100028368
    Abstract: Compounds useful as antiproliferative agents according to formula (I): wherein Ar1, Ar2, Ar3, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
    Type: Application
    Filed: December 12, 2007
    Publication date: February 4, 2010
    Applicant: TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: E. Premkumar Reddy, M.V. Ramana Reddy
  • Patent number: 7569711
    Abstract: Described herein are new enone derivatives and conjugates. Additionally, methods for synthesizing these new enones are also disclosed. These compounds can be employed in cancer therapy.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: August 4, 2009
    Assignee: Cornell Univeristy
    Inventors: Bruce Ganem, Donald J. Creighton, Diana S. Hamilton, Zhebo Ding
  • Publication number: 20080305956
    Abstract: What is described are 3-cyclopropyl-4-(3-thiobenzoyl)pyrazoles of the general formula (I) and their use as herbicides In this formula (I), R1, R2, R3, X and Y are radicals such as hydrogen and organic radicals, such as alkyl. R4 is hydrogen or a protective group, such as tosyl.
    Type: Application
    Filed: June 9, 2008
    Publication date: December 11, 2008
    Applicant: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Andreas van Almsick, Stefan Lehr, Monika Schmitt, Jan Dittgen, Dieter Feucht, Martin Hills, Heinz Kehne, Christopher Rosinger
  • Publication number: 20080255370
    Abstract: The chemistry of [13C]methyl phenyl sulfide is exploited to produce new isotopically labeled precursors that allow for the facile assembly of a wide range of labeled molecules from simple and relatively inexpensive starting materials. These compounds are applicable to a variety of research areas such as quantum computing, metabolism and materials science.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 16, 2008
    Inventor: Rodolfo A. Martinez
  • Publication number: 20080255384
    Abstract: Alkoxy[13C]methyl phenyl sulfone is a precursor to the production of Lithium (E)-?-Alkoxy[1,2,3-13C3]acrylate and thence Alkoxy (E)-?-Alkoxy[1,2,3-13C3]acrylate. Alkoxy (E)-?-Alkoxy[1,2,3-13C3]acrylate can then serve as a precursor for the production of a number of other isotopically labeled compounds. Similar chemistry using Alkoxy[14C]methyl phenyl sulfone as the precursor can yield 14C labeled compounds. High purity precursors ensure that the new compounds are also highly pure.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 16, 2008
    Inventor: Rodolfo A. Martinez
  • Patent number: 7417072
    Abstract: The invention provides pharmaceutical compositions and methods of treating immunological disorders. The invention also provides pharmaceutical compositions and methods of inducing eosinophil apoptosis, and methods for treating eosinophil-associated disorders comprising inducing eosinophil apoptosis in an individual in need thereof.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: August 26, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James S. Malter, Stephane Esnault, Zhong-Jian Shen
  • Publication number: 20080058290
    Abstract: Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
    Type: Application
    Filed: March 15, 2005
    Publication date: March 6, 2008
    Applicants: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, ONCONOVA THERAPEUTICS INC.
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stanley C. Bell
  • Patent number: 7196229
    Abstract: The invention relates to benzoylcyclohexenone derivatives of general formula (I) wherein the variables R1 to R10 and n have the designation cited in claim 1.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: March 27, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang von Deyn, Ernst Baumann, Michael Hofmann, Markus Kordes, Ulf Misslitz, Liliana Parra Rapado, Cyrill Zagar, Matthias Witschel, Andreas Landes
  • Patent number: 6919380
    Abstract: Derivatives of C2-substituted indan-1-ol compounds of formula I: its physiologically acceptable salts, and its physiologically functional derivatives for the prophylaxis or treatment of obesity are disclosed herein. Compositions comprising the same, methods for preparing the instant compounds, and methods for reducing weight in mammals and for the prophylaxis or treatment of obesity are also described.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: July 19, 2005
    Assignee: Aventis Pharma Deutschland GmbH.
    Inventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
  • Patent number: 6803385
    Abstract: Hydroxyeicosatetraenoic acid esters and methods of their use in treating dry eye disorders are disclosed.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: October 12, 2004
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow
  • Publication number: 20040049083
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Application
    Filed: July 2, 2003
    Publication date: March 11, 2004
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Patent number: 6552084
    Abstract: Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: April 22, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow
  • Publication number: 20020173672
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: July 1, 2002
    Publication date: November 21, 2002
    Applicant: UNITED THERAPEUTICS CORPORATION
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
  • Patent number: 6451904
    Abstract: Novel polymer stabilizers are disclosed. The novel stabilizers have the general formula (R)qSn-(MR″-OCH2-R′CH]m-OT)4-q, P-[(OCH2-R′CH)mOT]3′ wherein M is O or S and R″is (CH2)pCO-, CO-(CH3)p, or CO(CH2)p-. About 0.005 to about 65 phr of the stabilizer can be used in a polymer having a halogen-containing repeating unit, such as poly(vinyl chloride), to reduce yellowing of an article made from the polymer after the article has been exposed to gamma radiation.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 17, 2002
    Assignee: Occidental Chemical Corporation
    Inventors: Qi Wang, Sandor Nagy
  • Patent number: 6372945
    Abstract: The present invention is directed to a new process for the synthesis of vinyl sulfoxides, in particular diarylvinyl sulfoxides
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 16, 2002
    Assignee: Eli Lilly and Company
    Inventors: James A. Aikins, Randal Scot Miller, Tony Y. Zhang
  • Patent number: 6294698
    Abstract: The present invention is directed to new, energy-efficient photoinitiators in the form of organic sulfur-containing compounds. The present invention is also directed to a method of generating reactive species which includes exposing one or more photoinitiators to radiation to form one or more reactive species. Also described are methods of polymerizing unsaturated monomers, methods of curing an unsaturated oligomer/monomer mixture, and methods of laminating using the photoinitiators of the present invention.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: September 25, 2001
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ronald S. Nohr, J. Gavin MacDonald
  • Patent number: 6288242
    Abstract: The invention relates to processes for preparing a compound of the formula and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula X above.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: September 11, 2001
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephanie Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Patent number: 6235198
    Abstract: To purify a dimethyl sulphoxide (DMSO), it is placed in contact with a plurality of cation exchange resins at least one of which is a resin of sulphonic type in —SO3H or —SO3NH4 form, it being possible for the other or others to be of chelating type. The DMSO thus obtained has an iron cation content lower than 1 ppb and a sodium cation content lower than 2 ppb.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: May 22, 2001
    Assignee: Elf Aquitaine Exploration
    Inventors: Annie Commarieu, Francis Humblot
  • Patent number: 6162445
    Abstract: Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: December 19, 2000
    Assignee: Centre International de Recherches Dermatologiques Galderma
    Inventor: Jean-Michel Bernardon
  • Patent number: 6040274
    Abstract: 2- Aroylcyclohexanediones I ##STR1## where X, Y=O or S;Ar=phenyl or heteroaryl in each case having 1-4 substituents: halogen, cyano, nitro, --N.dbd.N--Ph, C.sub.1 -C.sub.4 -alkoxycarbonyl, --N(R.sup.9)--COR.sup.10, --N(R.sup.9)--SO.sub.2 --R.sup.11, --SO.sub.2 --N(R.sup.9)R.sup.10, --S(O).sub.m --R.sup.8 or opt. subst. C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkyl or C.sub.1 -C.sub.4 -haloalkoxy;two adjacent C atoms of the phenyl or heteroaryl ring can also be bridged by means of a chain --C(R.sup.12).dbd.C(R.sup.13)--C(R.sup.14).dbd.C(R.sup.15)--, --Z.sup.1 --C(R.sup.12).dbd.N--, --Z.sup.1 --N.dbd.C(R.sup.12)--, --Z.sub.1 --C(R.sup.12).dbd.C(R.sup.13)--, --Z.sup.1 --C(R.sup.12).dbd.C(R.sup.13)--C(R.sup.14,R.sup.15)--, --Z.sup.1 --C (R.sup.12,R.sup.13)--C(R.sup.14,R.sup.15)--, --Z.sup.1 --C(R.sup.12,R.sup.13)--C(R.sup.14 R.sup.15)--Z.sup.2 --, --C(R.sup.12,R.sup.13)--Z.sup.1 --C(R.sup.14,R.sup.15)--C(R.sup.16,R.sup.17)--, --Z.sup.1 --N(R.sup.20)--Z.sup.2 --, --Z.sup.1 --Z.sup.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: March 21, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Jurgen Kast, Marcus Vossen, Wolfgang von Deyn, Stefan Engel, Regina Luise Hill, Uwe Kardorff, Martina Otten, Peter Plath, Helmut Walter, Karl-Otto Westphalen, Ulf Misslitz
  • Patent number: 6020530
    Abstract: To purify a dimethyl sulfoxide (DMSO), this DMSO is placed in contact with an ion exchange resin of sulfonic type in --SO.sub.3 NH.sub.4 form, and the DMSO is then separated from the resin. The DMSO thus obtained has an iron cation content lower than 1 ppb and a sodium cation content lower than 2 ppb.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: February 1, 2000
    Assignee: Elf Atochem S.A.
    Inventors: Annie Commarieu, Francis Humblot