Additional Ring Containing Patents (Class 568/807)
  • Patent number: 4127733
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: November 28, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4125558
    Abstract: A known effective choleretic, cis-2-hydroxy-2-phenyl-r-1-cyclohexane carboxylic acid is obtained with a novel method wherein 1-phenylcyclohexene is reacted with formaldehyde in formic acid or mixture of formic acid with other solvents. The reaction mixture is hydrolyzed (alkaline hydrolysis) to provide a substituted cyclohexanol concurrently with a substituted dioxan. The substituted diol is separated from the substituted dioxan and finally oxidized to obtain the expected acid.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: November 14, 1978
    Assignee: Guidotti Internationale S.A.
    Inventor: Cosimo B. Torsi
  • Patent number: 4118487
    Abstract: Azol-1-ylmethanes substituted on the methane carbon atom by (a) phenyl or lower alkyl and (b) by a biphenyl-4-yl, 4-phenoxyphenyl, 4-phenylthiophenyl, 4-phenylsulfinylphenyl or 4-phenylsulfonylphenyl group are antimycotic and antibacterial agents. The compounds, of which (biphenyl-4-yl)phenyl-imidazol-1-ylmethane is a typical example, are prepared from the correspondingly substituted carbinol through treatment with thionyl-bis-azole or from the correspondingly substituted methyl halide with the azole or a derivative thereof.
    Type: Grant
    Filed: December 5, 1975
    Date of Patent: October 3, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Wilfried Draber, Karl Heinz Buchel, Manfred Plempel
  • Patent number: 4117119
    Abstract: Prostaglandin analogues of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## X represents trans-vinylene or ethylene and Y represents cis-vinylene or ethylene, R represents hydrogen or alkyl of 1 through 12 carbon atoms, R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, or alkyl of 1 through 12 carbon atoms or an aryl group, with the proviso that at least one of the symbols R.sup.1, R.sup.2 and R.sup.3 represents an alkyl or aryl group, are new compounds possessing useful pharmacological properties; they are especially useful for the treatment of gastric ulceration.
    Type: Grant
    Filed: May 6, 1977
    Date of Patent: September 26, 1978
    Assignee: Ono Pharmaceutical Company
    Inventors: Masayasu Kurono, Hisao Nakai, Takashi Muryobayashi
  • Patent number: 4117234
    Abstract: Estrogenic steroids are synthesized by combining under conditions favoring the formation of a trans-olefin, a .gamma.-arylpropanal with a 5,5,8,8-tetraalkoxy Wittig reagent. After hydrolysis of the gem-diethers, the resulting dioxo is internally condensed to form a cyclopentenone. The ketone is reduced to an oxy group and the resulting 2-(6'-arylhex-3'-enyl-1)cyclopent-2-en-1-ol or derivative thereof is cyclized to the .DELTA..sup.13,17 -estrene, preferably 17-alkyl-.DELTA..sup.13,17 -estrene with the A ring aromatized. After epoxidation, the 17-alkyl derivative is rearranged to form the 13-alkyl-1,3,5(10)-estratien-17-one. New compounds are provided as intermediates and final products.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: September 26, 1978
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: William S. Johnson, Paul A. Bartlett
  • Patent number: 4115456
    Abstract: Alkyne compounds of the formula ##STR1## wherein R.sup.1 is H, alkyl of up to 4 carbon atoms or phenyl; R.sup.2 is H, aliphatic acyl of up to 6 carbon atoms or aroyl of up to 11 carbon atoms; R.sup.3 and R.sup.4 are H, F, Cl or Br and n is 0 or 1, and physiologicaly acceptable metals salts thereof, have antiinflammatory activity. These compounds can be made from compounds of the formula ##STR2## wherein Q is a functionally-modified hydroxy and R.sup.1, R.sup.3, R.sup.4 and n are as above by treatment with a solvolyzing agent.
    Type: Grant
    Filed: June 18, 1976
    Date of Patent: September 19, 1978
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Joachim Gante, Hans-Adolf Kurmeier, Dieter Orth, Erich Schacht, Albrecht Wild
  • Patent number: 4109015
    Abstract: The disclosure relates to novel 15-(3-aryl- or 3-aralkyl-cyclobutyl, -cyclopentyl and -cyclohexyl)-.omega.-pentanor prostaglandin analogues, for example 9.alpha.,11.alpha.,15.alpha.-trihydroxy-15-(trans-3-phenylcyclobutyl)-16,1 7,18,19,20-pentanor-5-cis, 13-trans-prostadienoic acid, to pharmaceutical or veterinary compositions containing such a compound, and to a method of inducing luteolysis in animals by orally administering such a compound.
    Type: Grant
    Filed: January 26, 1978
    Date of Patent: August 22, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventor: Peter Robert Marsham
  • Patent number: 4107444
    Abstract: Thermally stable, rigid, aliphatic diols of the formula ##STR1## where R is a substituted or unsubstituted arylene group are useful as intermediates for forming polymers such as thermally stable, rigid polyesters.
    Type: Grant
    Filed: December 16, 1976
    Date of Patent: August 15, 1978
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Elmore Louis Martin
  • Patent number: 4107181
    Abstract: The novel synthesis of chemical compounds of the structures 1 and 2 is disclosed. ##STR1## Compounds 1 and 2 are shown to be useful intermediates in prostaglandin synthesis.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: August 15, 1978
    Assignee: Regent of the University of California
    Inventor: David A. Evans
  • Patent number: 4103097
    Abstract: This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: September 12, 1977
    Date of Patent: July 25, 1978
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Patent number: 4101591
    Abstract: Haloloweralkyl ethynylbenzene compounds and their derivatives which are useful for the treatment for the relief of inflammation, pain and fever.
    Type: Grant
    Filed: November 23, 1976
    Date of Patent: July 18, 1978
    Assignee: William H. Rorer, Inc.
    Inventor: Julius Diamond
  • Patent number: 4097537
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: June 27, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4096337
    Abstract: The disclosure relates to novel 15-(3-aryl- or 3-aralkyl-cyclobutyl, -cyclopentyl and -cyclohexyl)-.omega.-pentanor prostaglandin analogues, for example 9.alpha.,11.alpha.,15.alpha.-trihydroxy-15-(trans-3-phenylcyclobutyl)-16,1 7,18,19,20-pentanor-5-cis,13-trans-prostadienoic acid, to pharmaceutical or veterinary compositions containing such a compound, and to a method of inducing luteolysis in animals by orally administering such a compound.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: June 20, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventor: Peter Robert Marsham
  • Patent number: 4089908
    Abstract: The compounds are 1-aryl-1-alknyl-1-(t-butyl)-substituted methanols, e.g. 3-(2'-naphthyl)-4,4-dimethyl-pent-1-yn-3-ol, are useful as hypolipidemic agents, and are prepared by reacting a 4-aryl-pivalophenone with a metallo-alkynyl reagent under Grignard reaction conditions.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: May 16, 1978
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4087468
    Abstract: Grignard reagents of halo-substituted conjugated dienes are prepared by reaction of 1- or 2-halo-substituted conjugated diene with magnesium metal employing a metal halide/saturated aliphatic halide catalyst system. The Grignard reagent can be employed in the preparation of hydroxy-substituted conjugated dienes and hydroxy-substituted allenes. Adjustment of the molar ratio of the metal halide to the halo-substituted conjugated diene permits favoring of hydroxy-substituted conjugated dienes or hydroxy-substituted allenes in the diene products.
    Type: Grant
    Filed: December 12, 1975
    Date of Patent: May 2, 1978
    Assignee: Phillips Petroleum Company
    Inventor: Paul W. Solomon
  • Patent number: 4087472
    Abstract: An olefinic hydrocarbon is isomerized utilizing a catalyst system consisting essentially of a mixture of a nickel complex of the formula (R.sub.3 P).sub.2 NiX.sub.2 and an alkali metal borohydride.
    Type: Grant
    Filed: August 16, 1976
    Date of Patent: May 2, 1978
    Assignee: Phillips Petroleum Company
    Inventor: William B. Hughes