Infrared, Visible Light, Or Ultraviolet Radiation Directed On Or Through Body Or Constituent Released Therefrom Patents (Class 600/310)
  • Patent number: 9265457
    Abstract: A tissue analyte measuring device (2) includes a light source (4) structured to emit unpolarized light toward the skin surface of a subject, and a detector assembly (8) configured to receive light reflected from the skin surface of the subject and the transcutaneous tissues of the subject, the detector assembly including a polarizing filter (12) and a number of light detector subassemblies (14). The polarizing filter is structured to filter out s-polarized light and pass only p-polarized light to light detector subassemblies. The light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at a predetermined angle with respect to a normal to a light emitting plane of the measuring device, wherein the predetermined angle is an angle (the Brewster's angle) at which only s-polarized light will be reflected by the skin surface when the unpolarized light is incident thereon.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: February 23, 2016
    Assignee: Koninklijke Philips N.V.
    Inventors: Srinivas Rao Kudavelly, Eduard Johannes Meijer
  • Patent number: 9259185
    Abstract: An ear sensor provides a sensor body having a base, legs extending from the base and an optical housing disposed at ends of the legs opposite the base. An optical assembly is disposed in the housing. The sensor body is flexed so as to position the housing over a concha site. The sensor body is unflexed so as to attach the housing to the concha site and position the optical assembly to illuminate the concha site. The optical assembly is configured to transmit optical radiation into concha site tissue and receive the optical radiation after attenuation by pulsatile blood flow within the tissue.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: February 16, 2016
    Assignee: MASIMO CORPORATION
    Inventors: Yassir Abdul-Hafiz, Ammar Al-Ali, Kevin Forrest, Eugene Mason, John Schmidt, Virginia Thanh Ta
  • Patent number: 9248282
    Abstract: Embodiments disclosed herein are directed to systems configured to power at least one device disposed in a living subject, apparatuses configured to be disposed in a living subject and export power stored in an energy-storage device, and related methods of powering at least one device disposed in the living subject.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: February 2, 2016
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Dennis J. Rivet, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 9241139
    Abstract: Observation is performed at a more appropriate sensitivity without reducing an image quality. Provided is a fluorescence observation device (1) including: an excitation light source (3) that emits excitation light to be radiated onto a subject (A); a fluorescence-image acquiring section (21) provided with an imaging element (18) that acquires a fluorescence image (G2) by imaging fluorescence produced in the subject (A) when the excitation light emitted from the excitation light source (3) is radiated onto the subject (A); and a sensitivity adjusting section (22) that adjusts, based on luminance information of the fluorescence image (G2) acquired by the imaging element (18) of the fluorescence-image acquiring section (21), a number of pixels for binning summing (B) and/or an exposure time (t) in the imaging element (18) such that a SN ratio of the fluorescence image (G2) is equal to or larger than a predetermined threshold.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: January 19, 2016
    Assignee: OLYMPUS CORPORATION
    Inventor: Yasushige Ishihara
  • Patent number: 9226689
    Abstract: A surgical instrument is disclosed having an elongated body portion having a proximal end and a distal end. The body portion is formed from a plastically deformable material such that the body portion can be bent between the proximal and distal ends from a first configuration to a second bent configuration and maintains the bent configuration. A flexible circuit having at least a pair of lead wires disposed around the body portion. The pair of lead wires are configured to conform to the bent configuration of the body portion such that they do not break during bending of the body portion. A tracking device adapted to cooperate with a navigation system to track the distal end of the instrument is coupled to the flexible circuit.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: January 5, 2016
    Assignee: MEDTRONIC XOMED, INC.
    Inventors: Brad Jacobsen, Bruce M. Burg, Orey G. Block, Andrew Bzostek, Vince J. Doerr, Abhishek Jain, Brandon Merkl, Joseph Thomas Cilke
  • Patent number: 9226666
    Abstract: A method for determining a ratio of hemoglobin absorption within a biological tissue using a handheld device is provided. The method includes focusing at least one light pulse into a predetermined area inside an object using at least one excitation wavelength, wherein a fluorescence signal is based on at least a local excitation optical fluence and properties of fluorophores in the predetermined area. The method further includes receiving a photoacoustic signal emitted by the object in response to the at least one light pulse, the photoacoustic signal being a product of the local excitation optical fluence, an optical absorption coefficient of hemoglobin, and an acoustic detection sensitivity. The method further includes determining the ratio of hemoglobin absorption based on a hemoglobin absorption coefficient that is based at least partially on the fluorescence signal and the photoacoustic signal.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: January 5, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Lihong Wang, Konstantin Maslov
  • Patent number: 9220411
    Abstract: In-vivo optical molecular imaging methods for producing an image of an animal are described. A time series of image data sets of an optical contrast substance in the animal is acquired using an optical detector Each image data set is obtained at a selected time and has the same plurality of pixels, with each pixel having an associated value. The image data sets are analyzed to identify a plurality of distinctive time courses, and respective pixel sets are determined from the plurality of pixels which correspond to each of the time courses. In one embodiment, each pixel set is associated with an identified anatomical or other structure, and an anatomical image map of the animal can be generated which includes one or more of the anatomical structures.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: December 29, 2015
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventor: Elizabeth M.C. Hillman
  • Patent number: 9220460
    Abstract: A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: December 29, 2015
    Assignee: Nellcor Puritan Bennett Ireland
    Inventors: Paul Stanley Addison, James Nicholas Watson
  • Patent number: 9220423
    Abstract: A physiological monitoring system may determine physiological information, such as physiological rate information, from a physiological signal. The system may receive a calculated value indicative of a period associated with a physiological rate. The system may generated a first sorted difference signal based on a segment of the physiological signal having a size corresponding to the period. The system may generate second and third sorted difference signals based on segments of the physiological signal having sizes corresponding to a fraction of the period and a multiple of the period. The system may analyze the first, second, and third sorted difference signals, and qualify or disqualify the calculated value based on the analysis.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: December 29, 2015
    Assignee: Covidien LP
    Inventors: Fernando Rodriguez-Llorente, Pirow Engelbrecht, Nicholas James Wooder
  • Patent number: 9222832
    Abstract: The invention relates to a device for detecting and monitoring ingredients or properties of a measurement medium, for example physiological blood values, wherein said device contains a light source (20) for generating broad-spectrum measurement light (2) and for acting on a measurement area (3), and means (9) for fanning out the analysis light (4) reflected by the measurement area (3). The device also has a sensor array (11) for picking up the fanned light. The sensor array (11), the light source (20) and the means for dispersing the analysis light (4) are arranged as a compact unit in a housing.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: December 29, 2015
    Assignee: Senspec GmbH
    Inventor: Axel Kulcke
  • Patent number: 9216000
    Abstract: A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: December 22, 2015
    Assignee: ViOptix, Inc.
    Inventors: Kate LeeAnn Bechtel, Lester John Lloyd
  • Patent number: 9204843
    Abstract: There is provided an operation method of an optical distance measurement system including a first mode and a second mode. The first mode is configured to detect a finger distance. The second mode is configured to detect a physiological characteristic, wherein the optical distance measurement system transfers from the first mode to the second mode when the finger distance is within a predetermined range. There is further provided an optical distance measurement system.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: December 8, 2015
    Assignee: PIXART IMAGING INC.
    Inventors: Ren-Hau Gu, Chi-Chieh Liao, Ming-Tsan Kao, Sen-Huang Huang
  • Patent number: 9198624
    Abstract: The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: December 1, 2015
    Assignee: HITACHI MEDICAL CORPORATION
    Inventors: Tsukasa Funane, Hirokazu Atsumori, Takusige Katura, Masashi Kiguchi, Tsuyoshi Takatera, Michiyuki Fujiwara
  • Patent number: 9186797
    Abstract: A multi-axis force sensing apparatus that is installed at an operational end of a surgery robot and is capable of measuring force acting upon the operational end and a robot arm including the force sensing apparatus includes a body that is elastically deformable and has a pipe form extending along an axial direction of the body, an optical fiber strain gauge attached to a surface of the body to measure a tension and compression of the body in at least three directions. The optical fiber strain gauge may include at least three fiber Bragg gratings (FBGs) that are attached to the surface of the body and extended in an axial direction of the body, a light source providing light to each of the FBGs, and a light detector detecting light reflected by the FBGs or light that has passed through the FBGs.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: November 17, 2015
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jun-hyung Kim, Hyun-do Choi, Yeon-ho Kim, Chang-bae Park
  • Patent number: 9183427
    Abstract: A diagnostic system comprises a spectral image pickup means that picks up a spectral image in a predetermined wavelength region in a body cavity and obtains spectral image data, an image processing means that obtains, from the spectral image data, an index-value for discriminating between a diseased portion and a healthy portion, and generates and outputs an indicator image based on the index-value, and a monitor on which the indicator image is displayed, wherein, for each pixel of the spectral image, the image processing means defines ? obtained by a predetermined expression as the index-value, while using the spectral image data P1 at a first wavelength which is around a wavelength of 542 nm, the spectral image data P2 at a second wavelength which is around a wavelength of 558 nm and the spectral image data P3 at a third wavelength which is around a wavelength of 578 nm.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: November 10, 2015
    Assignee: HOYA CORPORATION
    Inventor: Toru Chiba
  • Patent number: 9179874
    Abstract: A physiological sensor assembly includes a physiological sensor having at least one light source and at least one optical receiver. A substantially transparent barrier layer is disposed between the physiological sensor and the patient's skin such that the barrier layer is removably adhered to the physiological sensor and removably adhered to the patient's skin.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: November 10, 2015
    Assignee: Covidien LP
    Inventors: Oleg Gonopolskiy, Arik Anderson, Ronald A. Widman
  • Patent number: 9162058
    Abstract: Embodiments disclosed herein are directed to systems configured to power at least one device disposed in a living subject, apparatuses configured to be disposed in a living subject and export power stored in an energy-storage device, and related methods of powering at least one device disposed in the living subject.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 20, 2015
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Dennis J. Rivet, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 9162057
    Abstract: Embodiments disclosed herein are directed to systems configured to power at least one device disposed in a living subject, apparatuses configured to be disposed in a living subject and export power stored in an energy-storage device, and related methods of powering at least one device disposed in the living subject.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 20, 2015
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Dennis J. Rivet, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 9149224
    Abstract: Described herein are systems and techniques for a motion capture system and a three-dimensional (3D) tracking system used to record body position and/or movements/motions and using the data to measure skin strain (a strain field) all along the body while a joint is in motion (dynamic) as well as in a fixed position (static). The data and technique can be used to quantify strains, calculate 3D contours, and derive patterns believed to reveal skin's properties during natural motions.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: October 6, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Dava J. Newman, Ashley M. Wessendorf
  • Patent number: 9138181
    Abstract: Medical sensors configured to provide enhanced patient comfort when worn over a period of time are provided. The medical sensors may include a first padding layer and a second padding layer disposed on either side of an emitter and a detector for measuring a physiological parameter of a patient. The medical sensors may also include an island padding layer secured to a patient-facing side of the second padding layer for reducing localized pressure points that may be caused by protrusions of the sensor. Additionally or alternatively, certain edges of the sensors may be rounded and/or stepped to reduce marking on the patient's tissue and to reduce strain and shear forces produced on the patient's tissue. Still further, certain embodiments provide enhanced light transmission between the emitter and detector of the sensors.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 22, 2015
    Assignee: COVIDIEN LP
    Inventors: Charles K. Haisley, Andy S. Lin, Friso Schlottau, Sarah Hayman
  • Patent number: 9131851
    Abstract: There are provided a biological information imaging apparatus that can measure ultrasound generated from an optical absorber in a deep part of a subject living body with high sensitivity, and a method for analyzing biological information using the biological information imaging apparatus. The biological information imaging apparatus that detects ultrasound and images biological information, includes: a light source that irradiates the subject with light for generating ultrasound from an optical absorber existing in the subject; an ultrasound transmission unit that transmits focused ultrasound to a specific region where the optical absorber exists; and an ultrasound detection unit that detects an ultrasound synthesized signal due to interaction between ultrasound generated from the optical absorber that absorbs the light and the focused ultrasound transmitted to the specific region.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: September 15, 2015
    Assignee: Canon Kabushiki Kaisha
    Inventors: Kazuhiko Fukutani, Takao Nakajima, Yasufumi Asao
  • Patent number: 9126049
    Abstract: An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: September 8, 2015
    Assignee: Medtronic, Inc.
    Inventors: Jonathan L. Kuhn, Can Cinbis, David A. Anderson, James K. Carney
  • Patent number: 9113795
    Abstract: Some embodiments provide a wearable fitness monitoring device including a motion sensor and a photoplethysmographic (PPG) sensor. The PPG sensor includes (i) a periodic light source, (ii) a photo detector, and (iii) circuitry determining a user's heart rate from an output of the photo detector. Some embodiments provide methods for operating a heart rate monitor of a wearable fitness monitoring device to measure one or more characteristics of a heartbeat waveform. Some embodiments provide methods for operating the wearable fitness monitoring device in a low power state when the device determines that the device is not worn by a user. Some embodiments provide methods for operating the wearable fitness monitoring device in a normal power state when the device determines that the device is worn by a user.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: August 25, 2015
    Assignee: Fitbit, Inc.
    Inventors: Jung Ook Hong, Shelten Gee Jao Yuen
  • Patent number: 9084569
    Abstract: A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal in to separate output signals. Pre-demodulation signal values are used to adjust the demodulation scheme.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: July 21, 2015
    Assignee: Cercacor Laboratories, Inc.
    Inventors: Walter M. Weber, Ammar Al-Ali
  • Patent number: 9086365
    Abstract: Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. A sample is illuminated by, for example, a pulsed laser and following the absorption of optical energy, a photoacoustic pressure is generated via thermo-elastic expansion. The acoustic waves then propagate and are detected by a transducer. The optical absorption coefficient of the sample is quantified from spectra of the measured photoacoustic signals. Factors, such as system bandwidth and acoustic attenuation, may affect the quantification but are canceled by dividing the acoustic spectra measured at multiple optical wavelengths.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: July 21, 2015
    Inventors: Lihong Wang, Zijian Guo
  • Patent number: 9078560
    Abstract: The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: July 14, 2015
    Assignee: GLT ACQUISITION CORP.
    Inventors: Matthew J. Schurman, Walter J. Shakespeare, William Henry Bennett
  • Patent number: 9075054
    Abstract: The present invention is a C-reactive protein imprinted polymer film. The C-reactive protein antibody imprinted polymer film comprises a plurality of imprinted nanocavities with unified orientation and distribution formed by removing a plurality of C-reactive proteins from a polymer film. Its ability to capture the target proteins can achieve 99% compared with the natural antibodies. The present invention further provides a C-reactive protein microchip system formed by the dynamic capacitance sensing method with the above imprinted polymer film. The C-reactive protein microchip system comprises a body having a first chamber and a second chamber, and a detector.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: July 7, 2015
    Assignees: MACKAY MEMORIAL HOSPITAL, NATIONAL TSING HUA UNIVERSITY
    Inventors: Chien-Chong Hong, Szu-Ying Chen, Jia-Cherng Horng, Chie-Pein Chen
  • Patent number: 9063074
    Abstract: Light is introduced into a tissue sample. The resulting light that passes through the tissue sample may be spectrally analyzed to determine its intensity at a number of frequencies. From these intensities, a chemical nature of the tissue sample may be determined. By performing this process one or more times, a three-dimensional representation of the morphology of the tissue sample can be developed, and this representation may be used to determine whether the tissue sample is healthy or abnormal.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: June 23, 2015
    Assignee: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventor: Manibrata Paul
  • Patent number: 9066186
    Abstract: A light-based skin contact detector is described, including a boot having an index of refraction less than or equal to another index of refraction associated with skin at a frequency of light, a light emitter and detector coupled to the boot and configured to measure an amount of light energy reflected by an interface of the boot, and a digital signal processor configured to detect a change in the amount of light energy reflected by the interface. Embodiments relate to methods for detecting skin contact by measuring an amount of energy reflected by an interface when a boot is not in contact with skin, measuring another amount of energy reflected by another interface when the boot is in contact with the skin, and detecting a change between the amount of energy and the another amount of energy using a digital signal processor.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: June 23, 2015
    Assignee: AliphCom
    Inventor: Gregory C. Burnett
  • Patent number: 9055869
    Abstract: A physiological monitoring system may perform an optical measurement of a subject to assist a photoacoustic analysis of the subject. For example, an oblique-incidence diffuse reflectance measurement, photon density wave measurement, or other optical measurement may be used to determine one or more optical properties of a subject. Accordingly, the one or more optical properties may be used to determine an optical fluence at a region of the subject. In some arrangements, a physiological monitoring system may include an oximeter, and may use a calculated blood oxygen saturation value to assist a photoacoustic analysis. Photoacoustic analysis may include determining one or more physiological parameters based on a detected acoustic pressure response of a subject to a photonic signal via the photoacoustic effect.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: June 16, 2015
    Assignee: COVIDIEN LP
    Inventors: Youzhi Li, Bo Chen
  • Patent number: 9057689
    Abstract: Methods are disclosed for determining a value associated with an analyte in a sample. The methods include: determining a set of spectra from a model for light attenuation in the sample, where the model includes contributions from at least two different sources of light attenuation in the sample; determining a set of spectral correction factors associated with the analyte in the sample based on the set of spectra; and using the set of spectral correction factors to determine the value associated with the analyte of interest.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: June 16, 2015
    Assignees: University of Massachusetts, Reflectance Medical, Inc.
    Inventors: Babs R. Soller, Fengmei Zou, Ye Yang, Randy Ross, Boyan Peshlov
  • Patent number: 9050044
    Abstract: Systems and methods for measuring a physiological parameter of tissue in a patient are provided herein. In a first example, a method of measuring a physiological parameter of blood in a patient is provided. The method includes emitting at least two optical signals for propagation through tissue of the patient, detecting the optical signals after propagation, identifying propagation pathlengths of the optical signals, and identifying detected intensities of the optical signals. The method also includes processing at least the propagation pathlengths to scale the detected intensities for determination of a value of the physiological parameter.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: June 9, 2015
    Assignee: Covidien LP
    Inventors: Youzhi Li, Clark R. Baker, Jr.
  • Patent number: 9044181
    Abstract: A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway at a plurality of wavelengths to generate corresponding first detected light intensity output signals, detects emitted light scattered by the volume of tissue delivered along a second pathway different from the first pathway at a plurality of wavelengths to generate corresponding second detected light intensity output signals, determines whether a difference between the emitted light detected along the first pathway and the emitted light detected along the second pathway is greater than a predetermined threshold, and alters sensing by the device in response to the determining whether a difference is greater than the predetermined threshold.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: June 2, 2015
    Assignee: Medtronic, Inc.
    Inventors: Jonathan L. Kuhn, Can Cinbis, James K. Carney
  • Patent number: 9044149
    Abstract: One innovative aspect is directed to heart rate data collection. In some implementations, a circuit includes a light detector for generating a first electrical signal based on received light. The circuit includes a switching circuit, having a first and a second configuration, configured to receive a first voltage signal based on the first electrical signal and to switch among the first and the second configurations. The circuit includes first and second sampling circuits for sampling a value of the first voltage signal when the switching circuit is in the first configuration and second configurations, respectively. The circuit includes an ambient light cancellation circuit for generating a current signal to counter a first component of the first electrical signal when the first switching circuit is in the first configuration.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: June 2, 2015
    Assignee: Fitbit, Inc.
    Inventors: Peter W. Richards, Thomas Samuel Elliot, Shelten Gee Jao Yuen
  • Publication number: 20150148628
    Abstract: Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.
    Type: Application
    Filed: September 29, 2014
    Publication date: May 28, 2015
    Applicant: GEELUX HOLDING, LTD.
    Inventor: Marcio Marc ABREU
  • Publication number: 20150148636
    Abstract: An improved sensor (102) for respiratory and metabolic monitoring in mobile devices, wearables, security, illumination, photography, and other devices and systems uses a broadband ambient light (114), which is then transmitted to a target (125) such as the ear, face, or wrist of a living subject. Some of the scattered light returning from the target to detector (141) is passed through spectral filter set (155) to produce multiple detector regions, each region sensitive to a different narrowband wavelength range, and the detected light is spectrally analyzed to determine a measure of a physiology of the subject such as pulse, respiration, hydration, calories. Additional broadband light can be added when ambient light alone may be sufficient illumination for analysis.
    Type: Application
    Filed: November 26, 2014
    Publication date: May 28, 2015
    Inventor: David Alan Benaron
  • Patent number: 9041531
    Abstract: Systems and methods are disclosed herein to a radiation safety system comprising radiation emitting medical equipment; a radiation safety system controller connected to the radiation emitting medical equipment through a first communication means configured to determine a number of people within a radiation room housing the radiation emitting medical equipment and prevent the radiation emitting medical equipment from performing radiation emitting functions if the radiation safety system controller determines that more people than a maximum allowed number of people are presently in the radiation room; and a scanner connected to the radiation safety controller through a second communication means configured to detect people in the radiation room and communicate to the radiation safety system controller that a person has been detected.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: May 26, 2015
    Inventor: Maitland M. DeLand
  • Publication number: 20150141777
    Abstract: A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Applicant: Senseonics, Incorporated
    Inventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
  • Patent number: 9037205
    Abstract: Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: May 19, 2015
    Assignee: GLUSENSE, LTD
    Inventors: Tamir Gil, Yossi Gross, Orly Grinberg, Itamar Weisman, Tehila Hyman, Boaz Hyman
  • Patent number: 9037204
    Abstract: The present embodiments relate generally to patient monitoring system and, more particularly, to optical patient monitoring systems. In an embodiment, a physiological sensor includes a broadband emitter configured to emit two or more wavelengths of light into the tissue of a patient. The sensor also includes a charge coupled device (CCD) or complementary metal-oxide semiconductor (CMOS) photodetector array comprising a plurality of photodetectors. Each photodetector in the photodetector array is configured to receive the light from the tissue of the patient and to produce a corresponding output signal. Additionally, the sensor also includes one or more filter layers disposed on the plurality of photodetectors. The filter layers are configured to only allow light of particular wavelengths, polarizations, or both, to be received by each of the plurality of photodetectors.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: May 19, 2015
    Assignee: COVIDIEN LP
    Inventor: Friso Schlottau
  • Patent number: 9037206
    Abstract: An apparatus for a non-invasive sensing of biological analytes in a sample includes an optics system having at least one radiation source and at least one radiation detector; a measurement system operatively coupled to the optics system; a control/processing system operatively coupled to the measurement system and having an embedded software system; a user interface/peripheral system operatively coupled to the control/processing system for providing user interaction with the control/processing system; and a power supply system operatively coupled to the measurement system, the control/processing system and the user interface system for providing power to each of the systems. The embedded software system of the control/processing system processes signals obtained from the measurement system to determine a concentration of the biological analytes in the sample.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: May 19, 2015
    Assignee: Dominion Assets, LLC
    Inventors: Jeremy Grata, Michael N. Pitsakis
  • Publication number: 20150133751
    Abstract: Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.
    Type: Application
    Filed: June 11, 2014
    Publication date: May 14, 2015
    Inventors: Shona STEWART, Serena AUGUSTINE, Jeffrey COHEN, Ryan PRIORE
  • Patent number: 9031627
    Abstract: According to embodiments, techniques for signal processing using multiple signals are disclosed. A first scalogram may be generated from a first signal and a second scalogram may be generated from a second signal. A modified or masked scalogram may then be generated based on the first and second scalograms. The modified scalogram may then be used to determine at least one physiological parameter. In some embodiments, one or both of the first signal and the second signal may be photoplethysmograph (PPG) signals obtained from a pulse oximeter.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: May 12, 2015
    Assignee: Nellcor Puritan Bennett Ireland
    Inventors: Paul Stanley Addison, James Nicholas Watson
  • Patent number: 9031640
    Abstract: [Subject] To provide laser Doppler blood flow measuring method and device which achieve multi-dimensional measurement efficiently at a high degree of accuracy over a wide range with a simple optical system and device. [Solving Means] Laser light from a semiconductor laser 12 is split and formed into sheet lights Ls using a cylindrical lens 22, and the sheet lights Ls are crossed with each other at a predetermined position. A lens system 30 configured to form an image of scattered lights into a linear shape at a linear irradiation site Lx where the sheet lights Ls cross with each other is provided. An optical fiber array 32 having a plurality of optical fibers 34 is provided at an image-forming position of the lens system 30. Avalanche photodiodes 42 configured to convert the scattered lights which are shifted in frequency by the Doppler effect caused by the blood flow into electric signals for the each optical fiber 34 are provided.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: May 12, 2015
    Assignees: Institute of National Colleges of Technology, Japan, National Univeristy Corporation of Toyama
    Inventors: Tadashi Hachiga, Hiroki Ishida, Shunsuke Akiguchi, Hiroki Shirakawa, Tsugunobu Andoh, Yasushi Kuraishi
  • Patent number: 9026188
    Abstract: A measurement apparatus comprises a probe system (100) operably coupled, when in use, to a processing resource (134). The probe system (100) and the processing resource (134) are arranged, when in use, to measure an apparent thickness change of a volume of the medium (108) to be measured and to determine a physiological parameter using the measurement of the apparent thickness change.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: May 5, 2015
    Assignee: Lein Applied Diagnostics
    Inventors: Robin Taylor, Richard Holley, Austen Hearn
  • Publication number: 20150119661
    Abstract: A system and optimization algorithm for determining the preferred operational wavelengths of a device configured for measurement of molecular analytes in a sample. Operational wavelengths are determined by solving a system of equations linking empirically defined functions representative of these analytes, spectrally dependent coefficients corresponding to these analytes, path lengths traversed by waves probing the analytes at wavelengths corresponding to the absorption level described by the functions representative of these analytes, and, optionally, a cost-function taking into account at least one of spectral separation between the operational wavelengths, manufacturability of wave source(s) producing wave(s) at operational wavelength(s), and the noise factor associated with the operation of such wave source(s).
    Type: Application
    Filed: April 29, 2013
    Publication date: April 30, 2015
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Barry K. Gilbert, Clifton R. Haider, Gary S. Delp
  • Publication number: 20150110719
    Abstract: Described are catheters associated with a hydrogel for release of a molecule of interest. The molecule of interest may be an antibody. Further described are sensors useful for detecting the presence or amount of an analyte, and associated methods. A sensor for use in detecting the presence or amount of an analyte may comprise a catheter having one or more apertures. The sensor may also include means for detecting binding of the analyte to an antibody.
    Type: Application
    Filed: May 8, 2013
    Publication date: April 23, 2015
    Inventors: Zhao Jie, Li Min She
  • Publication number: 20150112170
    Abstract: A device and method for non-invasively measuring analytes and physiological parameters by measuring terahertz radiation emitted though biological tissue. Terahertz pulses are emitted from a miniaturized quantum cascade laser to a fiber optic array into the wrist of the user. A corresponding sensor on the opposite side of the wrist receives the terahertz signals that have been modified by interacting with organic molecules. The data from the sensor is compiled and analyzed on a RAM chip and logic chip, where a program uses an algorithm to compare measurements to a library of existing measurements and topographic maps generated when the user first dons the device. Once the algorithm has parsed all the data points, a value, such as blood glucose level, appears on a display of the device. The device may be equipped with a gasket to reduce ambient light from contacting the sensor.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Applicant: AMERSON, LLC
    Inventors: Robert Lee Amerson, III, Robert Lee Amerson, II, Elizabeth Roshae Amerson
  • Patent number: 9011330
    Abstract: An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more sensors on the chip layer and coupled to the power source and a hydrogel matrix including one or more angiogenesis stimulating factors in contact with the chip layer. The stimulating factors stimulate growth of organic material through the plurality of holes when the biosensor is implanted in a subject.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: April 21, 2015
    Assignee: California Institute of Technology
    Inventors: Akram Sarwat Sadek, Axel Scherer, Muhammad Mujeeb-U-Rahman
  • Patent number: 9014772
    Abstract: In a special mode, a superficial wavelength set having plural types of narrow band light in a blue wavelength band of 400 to 500 nm is chosen. The plural types of narrow band light are successively applied to an internal body portion. A CCD captures images of the internal body portion under the narrow band light. A blood information calculation section calculates an oxygen saturation level of hemoglobin in a blood vessel based on an image signal. A comparison section compares the calculated oxygen saturation level with a predetermined threshold value. When the oxygen saturation level is less than the threshold value, a hypoxic region detection signal is outputted to a wavelength set switching section. The wavelength set switching section switches from the superficial wavelength set to a middle wavelength set and to a deep wavelength set, so the oxygen saturation levels at middle and deep depths are measured.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 21, 2015
    Assignee: FUJIFILM Corporation
    Inventors: Hiroshi Yamaguchi, Takaaki Saito