Glucose Patents (Class 600/316)
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Patent number: 9483619Abstract: A glycemic control system includes a physician processor, remote processor, and a portable telephone having a data input mechanism, a display, and an internal processor for bi-directional communication with the physician's processor and the remote processor. A patient inputs data to the internal processor responsive to input from the physician's processor and then transmits the information to the remote processor where an optimized number of units to be administered is sent back and displayed on the portable telephone.Type: GrantFiled: September 22, 2015Date of Patent: November 1, 2016Assignee: Aseko, Inc.Inventors: Robert C. Booth, Robert E. Fischell
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Patent number: 9480426Abstract: A process is described for testing a biomedical property of an internal tissue of a patient. Optical energy emitted by an external source is transferred through a nail of the patient to an instrument device implanted beneath the nail. A portion of the transferred optical energy is converted to electrical power for driving components of the implanted instrument. Using the electrical power, a characteristic of the internal tissue associated with the measurement of the biomedical property is sensed and an optical signal based on the sensed characteristic is transmitted through the nail to an external data reader.Type: GrantFiled: January 13, 2014Date of Patent: November 1, 2016Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Aditya Rajagopal, Axel Scherer, Akram Sarwat Sadek
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Patent number: 9456772Abstract: A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris.Type: GrantFiled: August 27, 2014Date of Patent: October 4, 2016Assignee: The University of ToledoInventors: Brent D. Cameron, Anthony J. Webb
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Patent number: 9459203Abstract: A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves.Type: GrantFiled: January 12, 2016Date of Patent: October 4, 2016Assignee: Zyomed, Corp.Inventors: Sandeep Gulati, Timothy L. Ruchti, William Van Antwerp, John L. Smith
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Patent number: 9448165Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The collection of radiation and/or illumination is controlled either to target a particular volume of the medium or such that the spectral energy changes become directionally monotonic with respect to analyte concentration, or both. The collection parameters include: duration of collection, location and/or a size of a collection spot on the medium surface, and angle of a collector relative to the medium surface. The illuminated and/or collection spots may be treated to improve accuracy of analyte measurement.Type: GrantFiled: March 25, 2016Date of Patent: September 20, 2016Assignee: Zyomed Corp.Inventors: Sandeep Gulati, Timothy L. Ruchti, John L. Smith, William Van Antwerp
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Patent number: 9427182Abstract: A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.Type: GrantFiled: December 27, 2013Date of Patent: August 30, 2016Assignee: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Patent number: 9427181Abstract: A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.Type: GrantFiled: December 27, 2013Date of Patent: August 30, 2016Assignee: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Patent number: 9420965Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.Type: GrantFiled: July 1, 2011Date of Patent: August 23, 2016Assignee: DexCom, Inc.Inventors: James H. Brauker, Victoria Carr-Brendel, Paul V. Goode, Apurv U. Kamath, James P. Thrower, Ben Xavier
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Patent number: 9414775Abstract: Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing.Type: GrantFiled: July 9, 2013Date of Patent: August 16, 2016Assignee: Senseonics, IncorporatedInventors: Arthur E. Colvin, Jr., Xiaolin Wang, Colleen Mdingi, Andrew DeHennis
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Patent number: 9364173Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.Type: GrantFiled: September 23, 2009Date of Patent: June 14, 2016Assignee: DexCom, Inc.Inventors: James H. Brauker, Victoria Carr-Brendel, Paul V. Goode, Apurv U. Kamath, James P. Thrower, Ben Xavier
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Patent number: 9314196Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.Type: GrantFiled: September 7, 2012Date of Patent: April 19, 2016Assignee: DexCom, Inc.Inventors: Jack Pryor, Apurv Ullas Kamath, Paul V. Goode, James H. Brauker
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Patent number: 9295383Abstract: The present application describes the acquisition of a tomographic image indicating a polarization state of a subject; a region is extracted from the tomographic image; and a first index indicating a first form in the region and a second index indicating a second form in the region are displayed.Type: GrantFiled: August 23, 2013Date of Patent: March 29, 2016Assignee: Canon Kabushiki KaishaInventors: Yoshihiko Iwase, Makoto Sato, Tomoyuki Makihira, Kazuhide Miyata, Hiroyuki Shinbata, Ritsuya Tomita, Daisuke Kibe
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Patent number: 9295419Abstract: It is disclosed a device for measuring a concentration of glucose, for example, in a translucent piece of a body, like an earlobe, a tissue connecting two fingers, a nasal ala, or a cheek. The piece is illuminated by a linearly polarized laser beam at a certain polarization direction. Consequently, a diffused radiated light is emitted from the piece, including a directed beam. The device includes a polarizing beam splitter which receives the directed beam, a lens, a sensor array, and means for connecting to a processor. The splitter splits components of the directed beam at two mutually orthogonal linear polarization directions into two polarized beams propagating at two respective different directions. The lens images the distribution of the directed beam on the translucent piece on two spatially separated groups within the sensor arrays.Type: GrantFiled: May 6, 2013Date of Patent: March 29, 2016Assignee: T.G.M. TECHNOLOGIES LTDInventors: Aryeh Uri Weiss, Nataly Oren, Eitan Koren
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Patent number: 9274658Abstract: There is provided a method of detecting biomolecules using a capacitive touch screen receiving a touch with a conductor as an input signal to perform an output on a display screen, and more particularly to a method of detecting target biomolecules by applying biomolecules having electrical conductivity to a touch panel and detecting a change in capacitance of a surface of a touch panel generated according to the concentration of the biomolecules.Type: GrantFiled: January 10, 2012Date of Patent: March 1, 2016Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Hyun Gyu Park, Byoung Yeon Won
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Patent number: 9265455Abstract: A method is provided for initializing an analyte sensor, such as a glucose sensor. Where a sensor has been disconnected and reconnected, a disconnection time is determined and a sensor initialization protocol is selected based upon the disconnection time. The sensor initialization protocol may include applying a first series of voltage pulses to the sensor. A method for detecting hydration of a sensor is also provided.Type: GrantFiled: November 13, 2012Date of Patent: February 23, 2016Assignee: Medtronic MiniMed, Inc.Inventors: Rebecca K. Gottlieb, Chia-Hung Chiu, Ashwin K. Rao
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Patent number: 9239619Abstract: Various embodiments relate to apparatuses and methods of using light transmission thought compressed living tissue to detect force. Transmission of light through living tissue such as a finger is affected by how much the tissue is compressed, for example by the finger being pressing on a surface. Light is introduced into the tissue, passes through the tissue, and a sensor receives the light exiting the tissue. The compression of the tissue can be determined using various characteristics of the received light, such as the light intensity, as determined based at least partly on sensor readings.Type: GrantFiled: November 8, 2013Date of Patent: January 19, 2016Assignee: APPLIED INVENTION, LLCInventor: Michael Keesling
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Patent number: 9220449Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.Type: GrantFiled: July 9, 2013Date of Patent: December 29, 2015Assignee: DexCom, Inc.Inventors: Jack Pryor, Apurv Ullas Kamath, Paul V. Goode, Jr., James H. Brauker
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Patent number: 9188537Abstract: This invention relates to a sensing method and a sensing device for quantifying the concentration of an analyte by using the property that interaction between an analyte and a labeled compound changes fluorescence intensity. A fluorescence sensor is used to acquire fluorescence intensity at predetermined quantification time points. Then, the concentration of an analyte is quantified in accordance with a non-steady concentration quantification law including the relationship between the acquired fluorescence intensity and the time derivative quantity thereof.Type: GrantFiled: March 5, 2012Date of Patent: November 17, 2015Assignee: TERUMO KABUSHIKI KAISHAInventors: Toshio Fukai, Atsushi Matsumoto, Kazuya Matsumoto, Takuro Suyama
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Patent number: 9179871Abstract: Generally, embodiments of the invention relate to analyte determining devices (e.g., electrochemical analyte monitoring systems) that include an indicator element that provides information relating to service history of the analyte determining devices, including, for example, previous use of the analyte determining devices. Also provided are systems and methods of using the, for example electrochemical, analyte determining devices in analyte monitoring.Type: GrantFiled: January 9, 2013Date of Patent: November 10, 2015Assignee: Abbott Diabetes Care Inc.Inventors: Zenghe Liu, Benjamin J. Feldman, Brian Cho
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Patent number: 9173604Abstract: A measurement device (1) includes a probe (7) which irradiates a specific part or a specific location of a living body with excitation light and which receives fluorescence generated by irradiating the specific part or the specific location with excitation light.Type: GrantFiled: November 17, 2010Date of Patent: November 3, 2015Assignee: SHARP KABUSHIKI KAISHAInventors: Mikihiro Yamanaka, Megumi Hijikuro, Keita Hara
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Patent number: 9171343Abstract: A glycemic control system includes a physician processor, remote processor, and a portable telephone having a data input mechanism, a display, and an internal processor for bi-directional communication with the physician's processor and the remote processor. A patient inputs data to the internal processor responsive to input from the physician's processor and then transmits the information to the remote processor where an optimized number of units to be administered is sent back and displayed on the portable telephone.Type: GrantFiled: September 14, 2012Date of Patent: October 27, 2015Assignee: Aseko, Inc.Inventors: Robert E. Fischell, Robert C. Booth
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Patent number: 9163985Abstract: A spectral characteristic measurement apparatus includes a spectrometer for spatially dispersing incident light depending on wavelengths and a detection portion for receiving light dispersed by the spectrometer. The detection portion includes a first detection area on which a component in a first wavelength range is incident and a second detection area on which a component in a second wavelength range is incident. The apparatus includes a correction portion for correcting stray light detected by the detection portion derived from light to be measured. The correction portion corrects a stray light pattern based on a first amount of change with respect to wavelengths in the first wavelength range of the stray light pattern and a second amount of change with respect to wavelengths included in a result of detection in the first detection area of the detection portion, to calculate a stray light component derived from the light to be measured.Type: GrantFiled: August 26, 2013Date of Patent: October 20, 2015Assignee: Otsuka Electronics Co., Ltd.Inventors: Hiroyuki Sano, Suguru Irie, Tsutomu Mizuguchi
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Patent number: 9155473Abstract: The present invention provides a reflection detection type measurement apparatus for skin fluorescence, which is configured to perform light irradiation and light detection on a reference sample and a measurement target.Type: GrantFiled: March 18, 2013Date of Patent: October 13, 2015Assignee: KOREA ELECTROTECHNOLOGY RESEARCH INSTITUTEInventors: Uk Kang, Garry V Papayan
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Patent number: 9121755Abstract: A novel emission and transmission optical spectrometer is introduced herein, which is capable of optically interrogating solid or liquid samples of organic, inorganic or polymeric chemistry, for pharmaceutical research, forensic and liquid analyses, used for identification, purity check, and/or structural study of chemicals. The beneficial aspects of the system are a single sample compartment as confined within the walls of the spectrometer housing, a more compact accessory, and the capability of making both emission (e.g., Raman and Fluorescence) and Infrared (IR, NIR) transmission measurements at designed sample points.Type: GrantFiled: September 10, 2012Date of Patent: September 1, 2015Assignee: THERMO ELECTRON SCIENTIFIC INSTRUMENTS LLCInventors: Federico Izzia, Michael S. Bradley
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Patent number: 9101308Abstract: A glucose sensor comprising an optical energy source having an emitter with an emission pattern; a first polarizer intersecting the emission pattern; a second polarizer spaced a distance from the first polarizer and intersecting the emission pattern, the second polarizer rotated relative to the first polarizer by a first rotational amount ?; a first optical detector intersecting the emission pattern; a second optical detector positioned proximal to the second polarizer, the first polarizer and the second polarizer being positioned between the optical energy source and the second optical detector, the second optical detector intersecting the emission pattern; a compensating circuit coupled to the second optical detector; and a subtractor circuit coupled to the compensating circuit and the first optical detector.Type: GrantFiled: June 2, 2014Date of Patent: August 11, 2015Assignee: K SCIENCES GP, LLCInventor: Valentin Korman
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Patent number: 9103793Abstract: The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.Type: GrantFiled: July 24, 2006Date of Patent: August 11, 2015Assignee: Massachusetts Institute of TechnologyInventors: Kate Bechtel, Wei-Chuan Shih, Michael S. Feld
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Patent number: 9087149Abstract: A method for conducting a Testing In Pairs (TIPs) blood glucose (bG) test using a handheld diabetes management device carried by a user. A processing subsystem of the device implements a software module for managing the TIPs test. The software module generates a plurality of predetermined acceptance time windows corresponding to different user defined events. The processing subsystem can identify specific ones of a plurality of bG test values read by the device that are obtained during the predetermined bG acceptance time windows, and which are identified as being related pairs of accepted bG test values that correspond to specific ones of the user defined events. The related pairs of accepted bG test values can then be stored in a database.Type: GrantFiled: October 15, 2010Date of Patent: July 21, 2015Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Paul J. Galley, John F. Price, Richard W. Wilson, Lisa McCool
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Patent number: 9078606Abstract: A system and method for measuring glucose levels in a user's blood without having to draw a blood sample. A wave energy source emits wave energy. A resonance chamber is provided that receives the wave energy and produces a frequency oscillation. An opening leads into the resonance chamber that is small yet enables a significant amount of sample tissue to bulge through the opening. The sample tissue of the user is pressed against the opening. At least a portion of the sample tissue passes through the opening and into the resonance chamber. The sample tissue loads the resonance chamber and alters the frequency oscillation created by the resonance chamber. At least some of the altered frequency oscillation is indicative of blood glucose levels within the sample tissue.Type: GrantFiled: August 5, 2011Date of Patent: July 14, 2015Inventor: Sarijit S. Bharj
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Patent number: 9066696Abstract: The present invention provides a sensor insertion and removing device which is user-friendly and which does not cause infection. The sensor insertion and removing device has a sensor; a puncture blade member; a housing which houses the sensor and the puncture blade member; a guide part which is provided within the housing and which glidably supports the puncture blade member; a puncture blade operating part which inserts the sensor under the skin by causing the puncture blade member to glide along the guide part integrally with the sensor, upon delivering the puncture blade member outside the housing to puncture the skin, and which causes the puncture blade member to glide along the guide part in a state of being separated from the sensor, upon removing the puncture blade member from under the skin into the housing, and a sensor operating part which pulls out the sensor from under the skin and removes it from under the skin into the housing.Type: GrantFiled: August 30, 2011Date of Patent: June 30, 2015Assignee: ARKRAY, Inc.Inventors: Tomohiro Shoshihara, Yosuke Murase, Akihiro Yamamoto
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Patent number: 9065554Abstract: System and methods for analyzing a network are disclosed. One method can comprise determining a parameter for each of a plurality of devices, generating a signature for each of the plurality of devices based upon the determined parameters, comparing the signatures of two or more of the plurality of devices, and grouping the plurality of devices based upon the comparison of the signatures of the two or more of the plurality of devices.Type: GrantFiled: August 1, 2012Date of Patent: June 23, 2015Assignee: Comcast Cable Communications, LLCInventors: Lawrence D. Wolcott, Jonathan A. Leech, Nicholas A. Pinckernell
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Patent number: 9056168Abstract: A system and method for automatically adjusting parameters for predicting blood glucose levels and/or controlling the dispensing of insulin. In one embodiment, the system is a stand-alone system. In one embodiment, the system is part of a system for controlling the dispensing of insulin.Type: GrantFiled: August 30, 2013Date of Patent: June 16, 2015Assignee: Dose SafetyInventors: Robert C. Kircher, Jr., Richard S. Mauseth, Jason N. Bishop, Donald P. Matheson, Suray Bhatia, Jeff A. Bilmes
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Publication number: 20150148627Abstract: A sensing system and method for sensing a component in a liquid is disclosed. The system comprises a microfluidic channel, the microfluidic channel comprising a first end and a second end, wherein the microfluidic channel is open at the first end and closed at the second end. The system also comprises at least one measurement sensor positioned adjacent the first end, the measurement sensor being arranged for detecting a measurement signal and a reference sensor positioned in the microfluidic channel adjacent the second end, the reference sensor being arranged for detecting a reference signal of the liquid. The system further is configured for combining the measurement signal and the reference signal so as to filter out background influences.Type: ApplicationFiled: November 27, 2013Publication date: May 28, 2015Applicant: UNIVERSITEIT GENTInventors: Roeland BAETS, Eva RYCKEBOER
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Publication number: 20150147275Abstract: A water-soluble compound of the formula (I): (Formula (I)) wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.Type: ApplicationFiled: April 26, 2013Publication date: May 28, 2015Inventors: Chenfeng Ke, Anthony P. Davis
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Publication number: 20150148628Abstract: Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.Type: ApplicationFiled: September 29, 2014Publication date: May 28, 2015Applicant: GEELUX HOLDING, LTD.Inventor: Marcio Marc ABREU
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Publication number: 20150141778Abstract: In a combination invasive and non-invasive bioparameter monitoring device an invasive component measures the bioparameter and transmits the reading to the non-invasive component. The non-invasive component generates a bioparametric reading upon insertion by the patient of a body part. A digital processor processes a series over time of digital color images of the body part and represents the digital images as a signal over time that is converted to a learning vector using mathematical functions. A learning matrix is created. A coefficient of learning vector is deduced. From a new vector from non-invasive measurements, a new matrix of same size and structure is created. Using the coefficient of learning vector, a recognition matrix may be tested to measure the bioparameter non-invasively. The learning matrix may be expanded and kept regular. After a device is calibrated to the individual patient, universal calibration can be generated from sending data over the Internet.Type: ApplicationFiled: December 24, 2014Publication date: May 21, 2015Inventor: Yosef SEGMAN
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Publication number: 20150141777Abstract: A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.Type: ApplicationFiled: November 14, 2014Publication date: May 21, 2015Applicant: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Patent number: 9037206Abstract: An apparatus for a non-invasive sensing of biological analytes in a sample includes an optics system having at least one radiation source and at least one radiation detector; a measurement system operatively coupled to the optics system; a control/processing system operatively coupled to the measurement system and having an embedded software system; a user interface/peripheral system operatively coupled to the control/processing system for providing user interaction with the control/processing system; and a power supply system operatively coupled to the measurement system, the control/processing system and the user interface system for providing power to each of the systems. The embedded software system of the control/processing system processes signals obtained from the measurement system to determine a concentration of the biological analytes in the sample.Type: GrantFiled: March 19, 2012Date of Patent: May 19, 2015Assignee: Dominion Assets, LLCInventors: Jeremy Grata, Michael N. Pitsakis
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Patent number: 9037205Abstract: Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described.Type: GrantFiled: June 30, 2011Date of Patent: May 19, 2015Assignee: GLUSENSE, LTDInventors: Tamir Gil, Yossi Gross, Orly Grinberg, Itamar Weisman, Tehila Hyman, Boaz Hyman
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Patent number: 9035767Abstract: Methods and systems for providing data communication in medical systems are disclosed.Type: GrantFiled: May 30, 2013Date of Patent: May 19, 2015Assignee: Abbott Diabetes Care Inc.Inventors: Martin J. Fennell, Lei He, Mark Kent Sloan
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Publication number: 20150133752Abstract: A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.Type: ApplicationFiled: September 16, 2014Publication date: May 14, 2015Inventors: Nicole M. Iverson, Michael S. Strano, Nigel F. Reuel, Thomas P. McNicholas
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Patent number: 9029164Abstract: An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with evaporative light scattering detection (ELSD); the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.Type: GrantFiled: November 18, 2013Date of Patent: May 12, 2015Assignee: Del Mar PharmaceuticalsInventors: Xiaoyun Lu, Mike Tso-Ping Li
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Publication number: 20150126830Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: ApplicationFiled: August 4, 2014Publication date: May 7, 2015Inventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
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Publication number: 20150119662Abstract: A device for detection or measurement of a carbohydrate analyte in fluid comprises: an optical sensor comprising components of an assay for carbohydrate analyte, the readout of which is a detectable or measurable optical signal, and a light guide having a distal portion optically coupled to the assay components and a proximal portion; and a reader for interrogating the optical sensor, the reader comprising an assay interrogating system including a lens; and an interface portion forming part of at least one of the optical sensor and the reader, the interface portion being capable of removably constraining the proximal portion of the light guide and the lens of the assay interrogating system in an optically coupled arrangement. The device may be combined with an insulin-infusion system.Type: ApplicationFiled: October 13, 2014Publication date: April 30, 2015Inventors: Eric Allan Larson, Voltaire Isaac Lebron, Kevin Holz, Jasson Rodriguez, Ameya Kantak, Soren Aasmul
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Publication number: 20150119661Abstract: A system and optimization algorithm for determining the preferred operational wavelengths of a device configured for measurement of molecular analytes in a sample. Operational wavelengths are determined by solving a system of equations linking empirically defined functions representative of these analytes, spectrally dependent coefficients corresponding to these analytes, path lengths traversed by waves probing the analytes at wavelengths corresponding to the absorption level described by the functions representative of these analytes, and, optionally, a cost-function taking into account at least one of spectral separation between the operational wavelengths, manufacturability of wave source(s) producing wave(s) at operational wavelength(s), and the noise factor associated with the operation of such wave source(s).Type: ApplicationFiled: April 29, 2013Publication date: April 30, 2015Applicant: Mayo Foundation for Medical Education and ResearchInventors: Barry K. Gilbert, Clifton R. Haider, Gary S. Delp
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Publication number: 20150112169Abstract: A finger-placement sensor fixture aligns and removably secures a finger to a sensor pad of a reusable finger-clip optical sensor so as to assure the finger is repeatably aligned between the sensors emitters and detectors and that the finger stays aligned during a test procedure. The sensor fixture has a sensor pad configured to removably install within a sensor clip. The sensor pad has a sensor cavity custom molded to the shape of an individual's fingertip. A plurality of metal strips are embedded within the sensor pad. A plurality of magnets are embedded within the sensor clip. The sensor pad metal strips are configured to align with the sensor clip magnets so that the sensor pad can be removed, disposed of, replaced and consistently aligned with the sensor clip.Type: ApplicationFiled: March 14, 2014Publication date: April 23, 2015Inventors: Marcelo M. Lamego, Hung The Vo, Cristiano Dalvi, Sean Merritt
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Publication number: 20150112170Abstract: A device and method for non-invasively measuring analytes and physiological parameters by measuring terahertz radiation emitted though biological tissue. Terahertz pulses are emitted from a miniaturized quantum cascade laser to a fiber optic array into the wrist of the user. A corresponding sensor on the opposite side of the wrist receives the terahertz signals that have been modified by interacting with organic molecules. The data from the sensor is compiled and analyzed on a RAM chip and logic chip, where a program uses an algorithm to compare measurements to a library of existing measurements and topographic maps generated when the user first dons the device. Once the algorithm has parsed all the data points, a value, such as blood glucose level, appears on a display of the device. The device may be equipped with a gasket to reduce ambient light from contacting the sensor.Type: ApplicationFiled: October 17, 2014Publication date: April 23, 2015Applicant: AMERSON, LLCInventors: Robert Lee Amerson, III, Robert Lee Amerson, II, Elizabeth Roshae Amerson
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Patent number: 9008742Abstract: An object of the present invention is to provide a noninvasive constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method, in which accurate measurement can be performed by superimposing two photoacoustic signals having the same frequency and reverse phases to nullify the effect from the other constituent occupying large part of the object to be measured. The constituent concentration measuring apparatus according to the invention includes light generating means for generating two light beams having different wavelengths, modulation means for electrically intensity-modulating each of the two light beams having different wavelengths using signals having the same frequency and reverse phases, light outgoing means for outputting the two intensity-modulated light beams having different wavelengths toward a test subject, and acoustic wave detection means for detecting an acoustic wave generated in the test subject by the outputted light.Type: GrantFiled: November 5, 2012Date of Patent: April 14, 2015Assignee: Nippon Telegraph and Telephone CorporationInventors: Kazunori Naganuma, Takuro Tajima, Yuichi Okabe, Shoichi Sudo
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Patent number: 9000886Abstract: The present invention relates to a method, computer program product, and system for preventing an inadvertent configuration of an electrical device provided with an infrared interface (30). The method, computer program product, and system include activation of one or more infrared buttons (31, 32, 33, or 34) provided on the infrared interface (30) in order to configure the electrical device. The method, computer program product, and system include a display (40) that indicates an infrared button sequence), wherein said button sequence is entered before the configuration occurs and includes activation of at least a first infrared button (31, 32, 33, or 34) and at least a second infrared button (31, 32, 33, or 34).Type: GrantFiled: April 1, 2008Date of Patent: April 7, 2015Assignee: Micro Motion, Inc.Inventors: Michael Ezra Sobel, Xiaoling DiGrazia
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Patent number: 8996089Abstract: A continuous analysis apparatus capable of transmitting information about components in body fluid to another apparatus such as medicine dosing apparatus more correctly without giving a user displeasure. The continuous analysis apparatus according to the present invention includes a sensing unit 2 including a sensor that is held in subcutaneous tissue for obtaining information with respect to an objective substance in a sample; and a data holding unit 3 having a storage means for storing the information obtained from the sensor or data corresponding to the information, the sensing unit and the data holding unit having configuration so that they are separably joined to each other.Type: GrantFiled: June 25, 2010Date of Patent: March 31, 2015Assignee: ARKRAY, Inc.Inventors: Kazuya Iketani, Koji Katsuki, Yasuhide Kusaka
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Publication number: 20150080685Abstract: Embodiments of the present invention relates to analyte sensors. In particular, the preferred embodiments of the present invention relate to non-consuming intravascular glucose sensors based on fluorescence chemistry.Type: ApplicationFiled: April 17, 2014Publication date: March 19, 2015Applicant: Medtronic MiniMed, Inc.Inventors: David R. Markle, William Markle