Determining Blood Constituent Patents (Class 600/322)
  • Patent number: 8996089
    Abstract: A continuous analysis apparatus capable of transmitting information about components in body fluid to another apparatus such as medicine dosing apparatus more correctly without giving a user displeasure. The continuous analysis apparatus according to the present invention includes a sensing unit 2 including a sensor that is held in subcutaneous tissue for obtaining information with respect to an objective substance in a sample; and a data holding unit 3 having a storage means for storing the information obtained from the sensor or data corresponding to the information, the sensing unit and the data holding unit having configuration so that they are separably joined to each other.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 31, 2015
    Assignee: ARKRAY, Inc.
    Inventors: Kazuya Iketani, Koji Katsuki, Yasuhide Kusaka
  • Publication number: 20150087938
    Abstract: Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor displays a line associated with a patient wellness level.
    Type: Application
    Filed: December 2, 2014
    Publication date: March 26, 2015
    Inventors: Ammar Al-Ali, Joe E. Kiani
  • Patent number: 8983564
    Abstract: An embodiment of the present disclosure seeks to smooth a perfusion index measurement through use of a baseline perfusion index measurement and/or through the use of multiple PI calculations. The combination of the baseline perfusion index measurement reduces an error between a calculated measurement of PI and actual conditions.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: March 17, 2015
    Assignee: Masimo Corporation
    Inventor: Ammar Al-Ali
  • Publication number: 20150073241
    Abstract: The present disclosure provides systems and methods for calibrating medical devices and processing physiological measurements using a medical device management system. As an example, the medical device can be a handheld glucometer configured for invasive testing and non-invasive testing of physiological parameters of a patient.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 12, 2015
    Inventor: Marcelo M. Lamego
  • Publication number: 20150065825
    Abstract: Devices, methods and systems are disclosed for assisting patients in behavioral modification and cessation programs aimed at terminating undesired behaviors such as smoking, alcohol use and others. Patient devices configured to be easily carried or worn including test units such as carbon monoxide blood level sensors with automated patient prompting for self-testing, analysis of test results and data logging are included in a networked system with a specifically designed treatment modality. Devices and methods disclosed are particularly suited to use in smoking cessation treatment and programs.
    Type: Application
    Filed: November 10, 2014
    Publication date: March 5, 2015
    Inventor: David Scott Utley
  • Patent number: 8969097
    Abstract: Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 3, 2015
    Assignee: Intuity Medical, Inc.
    Inventors: Jeffrey L. Emery, Carole R. Stivers
  • Patent number: 8971600
    Abstract: An ultrasonic diagnostic apparatus is provided for displaying a color map on which a difference in blood flow dynamics is reflected. Setting a test subject who is administered a contrast agent is assumed as an imaging target, and a probe transmits and receives ultrasonic waves to and from the target for contrast imaging. Image data is constructed based on signals received by the probe and a time-intensity curve is generated from intensity values of the image data. According to the time-intensity curve, a value of a predetermined parameter is calculated for producing a distribution image of blood flow dynamics. The distribution image (color map) of the blood flow dynamics is produced from the parameter value. The color map is a two-dimensional or a three-dimensional image being color-coded according to the parameter value.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: March 3, 2015
    Assignee: Hitachi Medical Corporation
    Inventors: Hideki Yoshikawa, Takashi Azuma
  • Patent number: 8964171
    Abstract: Methods and systems for identifying reticulocytes in a blood sample deposited on a substrate include: illuminating the sample with incident light at two different wavelengths, obtaining a two-dimensional image of the sample corresponding to a first one of the wavelengths, and obtaining a two-dimensional image of the sample corresponding to a second one of the wavelengths; analyzing the images to identify a set of representative red blood cells; determining an area of each of the red blood cells in the set; determining a color value of each of the red blood cells in the set; and, for each one of the red blood cells in the set, identifying the red blood cell as a reticulocyte if the area of the red blood cell exceeds an area cutoff value and the color value of the red blood cell is less than a color cutoff value.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: February 24, 2015
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Michael Zahniser, Russell Zahniser
  • Patent number: 8965471
    Abstract: A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site. The tissue profile is responsive to the physiological parameter. The limits are defined for at least a portion of the tissue profile.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: February 24, 2015
    Assignee: Cercacor Laboratories, Inc.
    Inventor: Marcelo Lamego
  • Patent number: 8965474
    Abstract: An in vivo monitoring method in a laparoscope system is provided. An object image is sequentially created with expression of a surface color of an object in a body cavity. A lock area (specific area) is determined within the object image, the lock area being movable by following motion of the object. A monitor image including a graph of oxygen saturation is generated according to a part image included in the object image and located in the lock area. The monitor image is displayed. Preferably, the oxygen saturation of the lock area is acquired according to two spectral data with respect to wavelengths of which an absorption coefficient is different between oxidized hemoglobin and reduced hemoglobin in data of the object image. The object is constituted by a blood vessel.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: February 24, 2015
    Assignee: FUJIFILM Corporation
    Inventor: Hiroshi Yamaguchi
  • Publication number: 20150051461
    Abstract: What is disclosed is a system and method for performing a medical diagnosis for a subject of interest using a RGB video camera and a spot radiometer in a non-contact, remote sensing environment. In one embodiment, video images are captured using a RGB video camera in real-time of a subject of interest for medical diagnostic purposes. The video images are analyzed to identify a region of exposed skin for which measurements are desired to be obtained. A relative position of a spot radiometer is then adjusted such that the spot radiometer can measure incident radiation at a desired wavelength range from the identified region of exposed skin. The measurements are then used to perform a medical diagnosis for the subject. Various embodiments are disclosed.
    Type: Application
    Filed: August 16, 2013
    Publication date: February 19, 2015
    Applicant: XEROX CORPORATION
    Inventors: Edul N. DALAL, Wencheng WU, Lalit Keshav MESTHA
  • Publication number: 20150051460
    Abstract: A non-invasive system (100) and method for locating blood vessel and analyzing blood of a subject under observation have been disclosed. The system (100) comprises a processor (108), an imaging module in communication with said processor (108) to capture at least a portion of a subject under observation and a display module (112) in communication with said processor to display said portion of the subject under observation (116). In further embodiments said processor (108) is configured to receive data from said imaging module and to construct a surface map of said portion of said section of said surface under observation (116).
    Type: Application
    Filed: April 4, 2013
    Publication date: February 19, 2015
    Inventors: NOOPUR SAXENA, SULAKSHNA SAXENA
  • Patent number: 8958858
    Abstract: A living-body component measuring apparatus measures a component of an inner tissue of a living body serving as an object to be measured by emitting laser light having two or more wavelengths from a light source and measuring reflected light of the laser light from the inner tissue of the living body. The living-body component measuring apparatus includes a beam splitter that changes optical paths of a part of the laser light and the reflected light, a reference-light measuring unit that measures, as reference light, the part of the laser light having the optical path changed by the beam splitter, a reflected-light measuring unit that measures the reflected light having the optical path changed by the beam splitter, and an analysis unit that analyzes the inner tissue by measuring a spectrum of the reflected light or the reference light.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: February 17, 2015
    Assignee: Yokogawa Electric Corporation
    Inventors: Shin-ichiro Tezuka, Hitoshi Hara
  • Publication number: 20150038813
    Abstract: A photoacoustic diagnosis device that diagnoses a state of a skin of a human body, includes a pulsed light source, an electric signal converter, a blood distribution obtaining section, and a diagnosis section. The pulsed light source generates a pulsed light. The electric signal converter receives a photoacoustic wave generated at the skin by the pulsed light and converts the photoacoustic wave into an electric signal. The blood distribution obtaining section obtains distribution of blood in the skin based on the electric signal. The diagnosis section diagnoses a state of the skin based on a result obtained by the blood distribution obtaining section.
    Type: Application
    Filed: May 2, 2013
    Publication date: February 5, 2015
    Inventors: Yasushi Kawaguchi, Taiichiro Ida
  • Patent number: 8948833
    Abstract: In a combination invasive and non-invasive bioparameter monitoring device an invasive component measures the bioparameter and transmits the reading to the non-invasive component. The non-invasive component generates a bioparametric reading upon insertion by the patient of a body part. A digital processor processes a series over time of digital color images of the body part and represents the digital images as a signal over time that is converted to a learning vector using mathematical functions. A learning matrix is created. A coefficient of learning vector is deduced. From a new vector from non-invasive measurements, a new matrix of same size and structure is created. Using the coefficient of learning vector, a recognition matrix may be tested to measure the bioparameter non-invasively. The learning matrix may be expanded and kept regular. After a device is calibrated to the individual patient, universal calibration can be generated from sending data over the Internet.
    Type: Grant
    Filed: January 23, 2011
    Date of Patent: February 3, 2015
    Assignee: Cnoga Ltd.
    Inventor: Yosef Segman
  • Publication number: 20150025342
    Abstract: Optical changes of tissue during wound healing measured by Near Infrared and Diffuse Reflectance Spectroscopy are shown to correlate with histologic changes. Near Infrared absorption coefficient correlated with blood vessel in-growth over time, while Diffuse Reflectance Spectroscopy (DRS) data correlated with collagen concentration. Changes of optical properties of wound tissue at greater depths are also quantified by Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths. The diffusion equation for semi-infinite media is used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain or time domain device. An increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared to the non wounded sites was observed. The changes correlated with the healing stage of the wound.
    Type: Application
    Filed: August 6, 2014
    Publication date: January 22, 2015
    Inventors: Elisabeth S. Papazoglou, Michael S. Weingarten, Leonid Zubkov, Michael T. Neidrauer, Linda Zhu, Kambiz Pourrezaei
  • Publication number: 20150025341
    Abstract: Blood information such as hemolysis (a plasma-free hemoglobin concentration) and a blood coagulation level (thrombus) can be obtained by extracting only reflected light in a plasma layer, and non-invasively and continuously obtaining information only on a plasma component independently of a hematocrit without separating blood components by a mechanical or chemical process. First measurement light 30 is caused to be incident on a boundary surface between blood 10 flowing through a flow cell 40 formed of a transparent material having a different refractive index from plasma (layer) 12 in the blood 10 and the flow cell 40, from an oblique direction at an angle smaller than 90 degrees. Reflected light 32 regularly reflected at the boundary surface between the flow cell 40 and the blood 10 is subjected to spectrometry. Information on a plasma component (a refractive index Np of plasma) is obtained from an absorption spectrum measured.
    Type: Application
    Filed: February 13, 2013
    Publication date: January 22, 2015
    Inventors: Daisuke Sakota, Setsuo Takatani
  • Publication number: 20150018646
    Abstract: A noninvasive analyzer apparatus and method of use thereof is described using a sample mapping phase to establish one or more analyzer/software parameters used in a subsequent individual and/or group specific data collection phase. For example, in the sample mapping phase distance between incident and collected light is varied as a function of time for collected noninvasive spectra. Spectra collected in the sample mapping phase are analyzed to determine a physiological property of the subject, such as dermal thickness, hydration, collagen density, epidermal thickness, and/or subcutaneous fat depth. Using the physiological property or measure thereof, the analyzer is optically reconfigured for the individual to yield subsequent spectra having enhanced features for noninvasive analyte property determination.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 15, 2015
    Inventors: Sandeep Gulati, Thomas George, Timothy Ruchti, Alan Abul-Haj, Kevin H. Hazen
  • Publication number: 20150011852
    Abstract: An optical sensor unit (10) for measuring a concentration of a gas is provided, comprising at least one sensing layer (122) adapted to be irradiated with a predetermined radiation; at least one gas-permeable layer (121) adjacent to one side of the at least one sensing layer (122) and adapted to pass gas which concentration is to be measured through the gas-permeable layer (121) towards the sensing layer (122); a removable protective layer (150) covering at least the gas-permeable layer (121) and adapted to be removed before use of the optical sensor unit (10), wherein the optical sensor unit (10) is adapted to measure an optical response of the at least one sensing layer (122), which optical response depends on the concentration of the gas.
    Type: Application
    Filed: February 19, 2013
    Publication date: January 8, 2015
    Inventors: Hans Willem Van Kesteren, Josephus Henricus Henricus Maria Kahlman, Nicolaas Lambert
  • Patent number: 8929628
    Abstract: The measuring unit computes at least one of an area and a perimetrical length of a polygon, based on three or more measuring points including an indeterminate point of which a position is changed by a move instruction input through an operation unit, wherein the measuring points are designated on the image by an instruction of a user input through the operation unit. The controller updates the position of the indeterminate point, when the move instruction is input through the operation unit after display the computational result, controls the measuring unit to recompute at least one of the area and the perimetrical length of the polygon based on the measuring points including the updated indeterminate point, and controls the display unit to display at least one of the recomputed area and the recomputed perimetrical length of the polygon, as recomputational result after updated the indeterminate point.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: January 6, 2015
    Assignee: Olympus Corporation
    Inventor: Kiyotomi Ogawa
  • Patent number: 8929964
    Abstract: A physiological sensor has light sources arranged in one or more rows and one or more columns. Each light source is activated by addressing at least one row and at least one column. The light sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: January 6, 2015
    Assignee: Cercacor Laboratories, Inc.
    Inventors: Ammar Al-Ali, Robert Smith, David Dalke, Mohamed Diab, Marcelo Lamego
  • Patent number: 8929967
    Abstract: A flexible sensor pad includes a cavity to hold a sensor unit with an attached cable. According to one aspect of the present invention, a light-shielding layer is coupled to a bottom surface of the sensor pad, surrounds the sensor unit, and extends past two sides of the sensor pad. A transparent adhesive layer is coupled to the light-shielding layer and extends past two sides of the light-shielding layer. Another light shielding layer is coupled to a top surface of the sensor pad and covers the sensor unit. The cable divides the sensor pad into a first side and a second side which are mirror images of each other.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: January 6, 2015
    Assignee: ViOptix, Inc.
    Inventors: Jimmy Jian-min Mao, Robert E. Lash
  • Patent number: 8922382
    Abstract: Aspects of the present disclosure include a sensor configured to store in memory indications of sensor use information and formulas or indications of formulas for determining the useful life of a sensor from the indications of sensor use information. A monitor connected to the sensor monitors sensor use and stores indications of the use on sensor memory. The monitor and/or sensor compute the useful life of the sensor from the indications of use and the formulas. When the useful life of the sensor is reached, an indication is given to replace the sensor.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: December 30, 2014
    Assignee: Masimo Corporation
    Inventors: Ammar Al-Ali, Walter M. Weber, Ryan Timothy McHale
  • Patent number: 8923944
    Abstract: There is provided a system and method for canceling shunted light. The method includes transmitting electromagnetic radiation at tissue of interest and generating a signal representative of detected electromagnetic radiation. A portion of the generated signal representing shunted light is canceled from the generated signal and the remaining portion of the generated signal is used to compute physiological parameters.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: December 30, 2014
    Assignee: Covidien LP
    Inventor: Ethan Petersen
  • Patent number: 8923945
    Abstract: Methods and systems are provided for transmitting and receiving photon density waves to and from tissue, and processing the received waves using wavelet transforms to identify non-physiological signal components and/or identify physiological conditions. A pulse oximeter may receive the photon density waves from the tissue to generate a signal having phase and amplitude information. A phase signal may be proportional to a scattering by total particles in the tissue, and an amplitude signal may correlate to an absorption by certain particles, providing information on a ratio of different particles in the tissue. Processing the phase and amplitude signals with wavelet transforms may enable an analysis of signals with respect to time, frequency, and magnitude, and may produce various physiological data.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: December 30, 2014
    Assignee: Covidien LP
    Inventor: Edward M. McKenna
  • Patent number: 8920317
    Abstract: A sensor port is adapted to connect to either a sensor or a data source. A reader is configured to identify which of the sensor and the data source is connected to the sensor port. A data path is configured to communicate an analog signal associated with the sensor and digital data associated with the data source to a signal processor according to the identification made by the reader.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: December 30, 2014
    Assignee: Masimo Corporation
    Inventors: Ammar Al-Ali, Robert A. Smith, Rex J. McCarthy
  • Patent number: 8922761
    Abstract: A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: December 30, 2014
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Michael Zahniser, Russell Zahniser
  • Publication number: 20140378777
    Abstract: A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 25, 2014
    Inventors: Andrew Conrad, Eric Peeters
  • Publication number: 20140371557
    Abstract: A biological signal measuring system includes: a light emitter emitting light beams having different N kinds of wavelengths, where N is an integer of four or more; a light receiver outputting N kinds of signals respectively in accordance with received light intensities of the N kinds of light beams that have been passed through or reflected from a living tissue; a first calculating section acquiring N kinds of light attenuations based on the N kinds of signals; a second calculating section acquiring (N?1) kinds of blood-derived light attenuations based on two light attenuations related to (N?1) kinds of combinations selected from the N kinds of light attenuations; a third calculating section identifying concentrations of (N?1) kinds of in-blood substances based on the (N?1) kinds of blood-derived light attenuations; and an outputting section outputting the identified concentrations.
    Type: Application
    Filed: May 23, 2014
    Publication date: December 18, 2014
    Applicant: NIHON KOHDEN CORPORATION
    Inventors: Naoki Kobayashi, Hideaki Hirabara
  • Patent number: 8914088
    Abstract: According to embodiments, sensors and systems for medical spectroscopy may include adaptive optical components, such as digital light processing components. Adaptive light emitting elements may allow such sensors to alter the intensity profile of emitted light photons to change the distribution of photons through the tissue or to scan areas of tissue to determine if certain areas may be associated with improved measurements. In addition, sensors with adaptive light detecting elements as provided may adapt to selectively detect light of certain wavelengths or from certain regions of the tissue.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: December 16, 2014
    Assignee: Covidien LP
    Inventors: Carl Buice, Edward McKenna
  • Publication number: 20140364708
    Abstract: Disclosed is an apparatus for measuring the indicators of a specific ingredient in a solution. According to one embodiment of the present invention, said apparatus comprises: a signal collector for collecting a plurality of signals from a target in a selected volume of the solution. Beam splitters for splitting said signals and several designs for generating and transmitting the signals to the detectors. After the signal's detection, a mold-in algorithm is used to remove the noise. The filtered signals are used to get several indicators, which are correlated to the concentration of ingredients in the solution. This apparatus is designed to enhance the power of the mold-in algorithm. The present invention provides an apparatus for effectively measuring in-situ without the need of extracting the solution out of its original container.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 11, 2014
    Inventor: Wei-Kung Wang
  • Patent number: 8909313
    Abstract: The invention relates to a device for diagnosis and/or therapy of a selected portion of a body by optical reflectance or optical transmission. The device according to the invention has a laminar body (12) containing a tissue-facing surface (13). The laminar body (12) integrally forms a transmitter opening destined to accommodate a transmitter fiber terminal (24) and a receiver opening destined to accommodate a receiver fiber terminal (38a, 38b). Furthermore, it contains annular light shielding means for shielding said transmitter fiber terminal (24) and receiver fiber terminal (38a, 38b) from ambient light sources. Thereby, said annular transmitter and receiver light shielding means are formed as an annular transmitter light shielding bulge (46) and an annular receiver light shielding bulge (48a, 48b), respectively, which are firmly arranged with respect to said laminar body (12), whereby their free ends are protruding with respect to said tissue-facing surface (13) of said laminar body (12).
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: December 9, 2014
    Assignee: NeMoDevices AG
    Inventor: Jürg Froehlich
  • Publication number: 20140343371
    Abstract: A device for monitoring health information. The device comprises a material capable of being worn on a person's body, an optical generator, an optical sensor, a processor, and an interface for communicating with an external device. The device may also include two EKG sensors. The device non-invasively monitors a variety of health characteristics and transmits the health data to a base station such as a smartphone. The base station includes a software application that can display, store, and analyze the user's health data. The user may review his health information on the base station's display. In an alternative embodiment, the base station transmits the health data to a secure remote server. The user may review his health information on a website associated with the remote server.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 20, 2014
    Inventors: THOMAS SKERIK SOWERS, II, JOHN F. VOLKMAR
  • Publication number: 20140336482
    Abstract: Disclosed is a laser device which can emit light having first and second wavelengths, having the advantage of increasing laser efficiency without causing an increase in cost. A flash lamp irradiates excitation light onto a laser rod. An optical resonator includes a pair of mirrors facing each other with the laser rod interposed therebetween. A wavelength switching unit includes a long path filter which transmits light having a wavelength equal to or greater than a first wavelength. The wavelength switching unit inserts the long path filter on the optical path of the optical resonator when the wavelength of laser light to be emitted is the first wavelength.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 13, 2014
    Inventors: Tadashi KASAMATSU, Kazuhiro HIROTA
  • Publication number: 20140323831
    Abstract: Provided is a measurement device including a measurement unit to radiate measurement light having a predetermined wavelength to at least a part of a living body, to detect the measurement light scattered inside the living body and then discharged from a surface of the living body, and to acquire a captured image of the living body by collecting the discharged measurement light using a lens array having a plurality of light receiving lenses arranged in an array shape, a vein position specification unit to specify a position of a vein present inside the living body based on the captured image, a vein depth specification unit to specify a depth of the vein based on the captured image, and a blood component estimation unit configured to estimate a blood component of the vein based on information obtained from the detected measurement light using the position and the depth of the vein.
    Type: Application
    Filed: December 3, 2012
    Publication date: October 30, 2014
    Applicant: SONY CORPORATION
    Inventor: Hideo Sato
  • Patent number: 8874181
    Abstract: A pulse oximeter method and apparatus which provides (1) a notch filter at a distance between a modulation frequency and a common multiple of commonly used power line frequencies (50, 60, 100 and 120) and also (2) a demodulation frequency greater than a highest pulse rate of a person and lower than any harmonic of 50, 60, 100 or 120 Hz, to filter ambient light interference, while choosing an optimum demodulation frequency that avoids interference from the notch filter or from harmonics of the line interference. Also, ambient light for any low frequency interference, such as power line interference, is measured both before and after each of the light emitter wavelengths and the average of the ambient light is then subtracted from the detected signal.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: October 28, 2014
    Assignee: Covidien LP
    Inventors: Ethan Petersen, William Shea, Bradford B. Chew
  • Publication number: 20140316227
    Abstract: The invention concerns a measurement device to capture at least one vital parameter of a person in a motor vehicle with a steering wheel. The measurement device includes a finger sensor device with an optical sensor device, where the finger sensor device is attached to the steering wheel in the transition zone between a steering wheel spoke and the hub of the steering wheel.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 23, 2014
    Inventors: Ludger Rake, Andreas Giefer, Joerg Meyer
  • Publication number: 20140316226
    Abstract: An exemplary system comprises an energy transmitter, an energy receiver, and an analyzer. The energy transmitter may project energy at a first wavelength and a second wavelength into tissue of a user, the first wavelength and the second wavelength being associated with at least one nutrient of a set of nutrients in blood of the user. The energy receiver may generate a composite signal based on a fraction of the energy at the first wavelength and the second wavelength, the fraction of the energy being received through the tissue of the user. The analyzer may separate the composite signal into a first signal corresponding to the first wavelength and a second signal corresponding to the second wavelength, and detect, in the blood of the user, a concentration of the at least one nutrient of the set of nutrients based on the first signal and the second signal.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 23, 2014
    Applicant: ECHO LABS, INC.
    Inventors: Elad Ferber, Pierre-Jean Cobut
  • Patent number: 8864821
    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: October 21, 2014
    Assignee: VisEn Medical, Inc.
    Inventors: Farouc Jaffer, Milind Rajopadhye
  • Patent number: 8868147
    Abstract: The invention relates generally to a probe interface method and apparatus for use in conjunction with an optical based noninvasive analyzer. More particularly, an algorithm controls a sample probe position and attitude relative to a skin sample site before and/or during sampling. For example, a sample probe head of a sample module is controlled by an algorithm along the normal-to-skin-axis. Preferably, the sample probe head is positioned in terms of 3-D location in the x-, y-, and z-axes and is attitude orientated in terms of pitch, yaw, and roll. Further, attitude of the probe head is preferably orientated prior to contact of the sample probe head with the tissue sample using indicators, such as non-contact distance feedback from capacitance sensor, contacting or non-contacting optical sensors, and/or contact electrical sensors.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: October 21, 2014
    Assignee: GLT Acquisition Corp.
    Inventors: Timothy W. Stippick, Thomas B. Blank, Timothy L. Ruchti, Christopher Slawinski
  • Publication number: 20140309506
    Abstract: Confidence in a physiological parameter is measured from physiological data responsive to the intensity of multiple wavelengths of optical radiation after tissue attenuation. The physiological parameter is estimated based upon the physiological data. Reference data clusters are stored according to known values of the physiological parameter. At least one of the data clusters is selected according to the estimated physiological parameter. The confidence measure is determined from a comparison of the selected data clusters and the physiological data.
    Type: Application
    Filed: March 18, 2014
    Publication date: October 16, 2014
    Applicant: Cercacor Laboratories, Inc.
    Inventors: Marcelo Lamego, Mohamed K. Diab, Ammar Al-Ali
  • Publication number: 20140303462
    Abstract: A device for applying a sensor to a measurement site on a patient's skin has a wall arrangement defining an applicator volume above the patient's skin The wall arrangement has a patient's side and a sensor side. At least one gas-permeable membrane separates the applicator volume into a first volume directed to the measuring site at the patient's side of the wall arrangement and a second volume separated from the patient's skin and directed to the sensor side of the wall arrangement.
    Type: Application
    Filed: September 25, 2012
    Publication date: October 9, 2014
    Inventors: Christoph Ellenberger-Girard, Dominik Rudmann, Peter Matthias Schumacher
  • Patent number: 8855732
    Abstract: In a non-invasive human metabolic condition measuring apparatus and method, a micro-light source emits an incident light having a wavelength from 329 nm to 473 nm to trigger a mitochondrial metabolite of a human mucosa tissue, and the metabolite is excited to generate a fluorescent signal having a wavelength from 405 nm to 572 nm, and the fluorescent signal is filtered by an optical filter, received by a micro receiver, and amplified by an amplification circuit sequentially, and then a filter circuit and an analog/digital conversion circuit of a microprocessing unit are provided for filtering and performing an analog/digital signal conversion respectively, so that the metabolite content can be calculated by the computation to provide human metabolic conditions, and a combination of micro components and circuits is used for miniaturizing the apparatus to provide a convenient carry of the apparatus.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: October 7, 2014
    Assignee: Southern Taiwan University
    Inventors: Jenq-Ruey Horng, Shoko Nioka, Chi-Jo Wang, Chih-Chieh Kang, Juing-Shian Chiou, Shih-Chung Chen, Chih-Kuo Liang, Ching-Lung Chu, Hung-Chi Yang, Lian-Jou Tsai, Tsung-Fu Jeng
  • Patent number: 8855734
    Abstract: In an embodiment, a sensor may be adapted to provide information related to its position on a patient's tissue. The sensor may include tissue contact sensors which may relay a signal related to the proper placement of the sensor relative to the tissue of a patient. Such a sensor may be useful for providing information to a clinician regarding the location of the sensor in relation to the skin of a patient in order to provide improved measurements.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: October 7, 2014
    Assignee: Covidien LP
    Inventors: Paul D. Mannheimer, Bruce R. Bowman, Lee M. Middleman, Clark R. Baker, Jr.
  • Patent number: 8855735
    Abstract: Systems and methods are provided for spectrophometric measurement of a physiological property of a patient. For example, an embodiment of a patient monitoring system may include a monitor operatively coupled to a spectrophotometric sensor, which may include an emitter configured to transmit light into tissue of the patient and a detector configured to receive the light from the tissue. The emitter may use a photonic crystal light emitting diode to generate the light.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: October 7, 2014
    Assignee: Covidien LP
    Inventor: Youzhi Li
  • Patent number: 8847740
    Abstract: An alarm suspend system utilizes an alarm trigger responsive to physiological parameters and corresponding limits on those parameters. The parameters are associated with both fast and slow treatment times corresponding to length of time it takes for a person to respond to medical treatment for out-of-limit parameter measurements. Audible and visual alarms respond to the alarm trigger. An alarm silence button is pressed to silence the audible alarm for a predetermined suspend time. The audible alarm is activated after the suspend time has lapsed. Longer suspend times are associated with slow treatment parameters and shorter suspend times are associated with fast treatment parameters.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: September 30, 2014
    Assignee: Masimo Corporation
    Inventors: Massi Joe E. Kiani, Steve L. Cebada, Gregory A. Olsen
  • Publication number: 20140288386
    Abstract: A surgical instrument may be configured to sense a light re-emitting probe to resolve tissue oxygenation, the surgical instrument including: an optical emitter configured to excite the light re-emitting probe within an absorption band of the light re-emitting probe; an optical detector configured to receive the re-emitted light from the probe; and a signal processor configured to resolve the tissue oxygenation based on the received light. The surgical instrument can be a surgical stapler anvil or a flexible substrate having a tissue interfacing surface. Further, a monitoring device may be configured to map oxygenation of a tissue containing a light re-emitting probe, the monitoring device including: an optical emitter configured to excite the light re-emitting probe; at least one optical detector configured to receive the re-emitted light from the probe; and a signal processor that is configured to resolve the tissue oxygenation at multiple points to generate an oxygen map.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 25, 2014
    Applicant: SURGISENSE CORPORATION
    Inventors: Jason M. ZAND, Gregory S. FISCHER
  • Publication number: 20140275835
    Abstract: A cloud-based physiological monitoring system has a sensor in communications with a living being so as to generate a data stream generally responsive to a physiological condition of the living being. A monitor receives the data stream from the sensor and transmits the data stream to a cloud server. The cloud server processes the data stream so as to derive physiological parameters having values responsive to the physiological condition. The cloud server derives a medical index based upon a combination of the physiological parameters. The cloud server communicates the medical index to the monitor, which displays the medical index.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Applicant: CERCACOR LABORATORIES, INC.
    Inventors: Marcelo M. Lamego, Abraham Mazda Kiani, Don Sanders, Jeroen Poeze, Massi Joe E. Kiani, Anthony Amir Davia
  • Publication number: 20140275872
    Abstract: A quality control system for patient monitors is disclosed. The quality control system can include a quality check insert having optical properties. In an embodiment, the insert is placed within a sensor, irradiated with light, and then the light is detected after attenuation by the insert. The detected light is processed using the same or different processing methodologies typically used to determine measurement values for physiological parameters of a monitored patient. When a patient monitor is functioning properly, the results of the processing provide values within a predetermined range of values. When the patient monitor is not functioning properly, the results of the processing provide values outside the predetermined range of values. The quality control system can include quality control parameters indicative of a properly functioning active pulse motor of the sensor, emitters of the sensor, detectors of the sensor, accelerometers of the sensors, and/or temperature sensors of the system.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Cercacor Laboratories, Inc.
    Inventors: Sean Merritt, Kevin Pauley, Jesse Chen, Justin Mathew Paul, Marcelo M. Lamego
  • Publication number: 20140275871
    Abstract: Embodiments of the disclosure include a noninvasive physiological patient sensor and a patient monitor capable of wireless communication with one another. An optical communication path can be used to provide the communication path between the noninvasive physiological patient sensor and the patient monitor. The path can be maintained by one or more light sources and detectors traditionally associated with noninvasive optical sensors or by one or more additional dedicated light sources and detectors.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: CERCACOR LABORATORIES, INC.
    Inventors: Marcelo M. Lamego, Massi Joe E. Kiani