Using Flexible Catheter Patents (Class 600/433)
  • Patent number: 10342956
    Abstract: Various methods employing transvascular access devices are described, including a method of placing a central catheter in a peripheral vein in an arm of a patient; a method of providing percutaneous access to the heart of a patient; a method of clearing a clotted arteriovenous dialysis graft; a method of creating multiple access points into a single blood vessel; a method of creating an AV fistula in a patient; and a method of providing a bypass to a blockage in a popliteal artery in a patient.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: July 9, 2019
    Assignee: Vascular Access Technologies, Inc.
    Inventor: Lakshmikumar Pillai
  • Patent number: 10314498
    Abstract: According to one embodiment, a tissue penetrating device includes an elongate shaft having a proximal end, a distal end, and a lumen extending there between. A first needle is disposed within the lumen of the elongate shaft and is extendable therefrom between a first configuration and a second configuration. In the first configuration, the first needle is disposed within the elongate shaft's lumen and is substantially aligned with an axis of the lumen. In the second configuration, the first needle extends distally of the elongate shaft's distal end and bends away from the lumen's axis. A second needle is disposed within a lumen of the first needle and is extendable therefrom when the first needle is positioned in the first configuration and when the first needle is positioned in the second configuration. The second needle may be extended from the first needle to penetrate tissue of a patient.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: June 11, 2019
    Assignee: BioVentrix, Inc.
    Inventors: Kevin Van Bladel, Meir Moshe, Lon Annest
  • Patent number: 10159462
    Abstract: A method is provided for creating a volume graphic via a catheter for introduction into a vessel which has an ultrasound unit, which is embodied to transmit ultrasound, to measure an echo of the transmitted ultrasound, and to create image data for a two-dimensional cross-section of the vessel on the basis of the measured echo. The method involves creating image data of a cross-section with the ultrasound unit at a plurality of different positions on a movement track of the catheter, and, in addition to the image data, creating position data for the current position of the ultrasound unit with a localization device. The method further involves creating the volume graphic from the image data of all cross-sections in which the cross-sections are arranged relative to one another in accordance with the position data.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: December 25, 2018
    Assignee: Siemens Healthcare GmbH
    Inventor: Yuan Jiang
  • Patent number: 10154826
    Abstract: A method for identifying a target anatomy by use of a device having an ultrasound transducer. Using the ultrasound transducer, a portion of a patient's anatomy is scanned during a scanning process. A voltage trace of the patient's anatomy is determined and compared to a predetermined trace. If the voltage trace of the patient's anatomy matches the predetermined trace, a notification may be output.
    Type: Grant
    Filed: July 12, 2014
    Date of Patent: December 18, 2018
    Assignee: Tissue Differentiation Intelligence, LLC
    Inventors: Kern Singh, Sachin Gupta, Michael Oelze
  • Patent number: 10124149
    Abstract: A deflectable catheter including an outer member having a proximal portion and a distal portion, an elongated column member extending distally from the outer member and an inner member positioned coaxial with the outer member and attached to the column member. The inner member extends distally of the outer member and has a distal tip portion. A reinforcement member is positioned over the column member to restrict axial movement of the column member such that when one of the inner member or outer member is moved with respect to the other, axial compression of the column member is restricted by the reinforcement member causing the distal tip portion of the inner member to deflect laterally.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: November 13, 2018
    Assignee: Curvo Medical, Inc.
    Inventor: Stephen J. Hebert
  • Patent number: 10123871
    Abstract: An implant capsule (10) and an implant delivery system are disclosed. The implant capsule (10) includes, sequentially from a proximal end to a distal end, a flexural section (102, 102a-102e), a reinforcement section (101, 101a-101e) and a radiopaque reinforcement ring (104a-104e). The reinforcement section (101, 101a-101e) has higher strength than the flexural section (102, 102a-102e). The implant delivery system includes the implant capsule (10). The implant capsule (10) can ensure the implant to be deployed in a coaxial condition and prevent over-expansion due to large expansion forces exerted by a stent of the implant.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: November 13, 2018
    Assignee: Shanghai Microport Cardioflow Medtech Co., Ltd.
    Inventors: Xiang Liu, Baozhu Gui, Yu Li, Mingming Wu, Zhixiu He, Haishan Wang
  • Patent number: 10078713
    Abstract: Cardiac catheterization is carried out by constructing a left atrial model of a heart of a living subject, selecting a global catheter that is dimensioned to conform to the left atrial model, representing the catheter in the left atrial model; extending the length axis of the catheter in the left atrial model to form an intersection with the foramen ovale, and reporting the intersection as a recommended site of transseptal puncture for insertion of the catheter therethrough.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: September 18, 2018
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Shmuel Auerbach, Aharon Turgeman
  • Patent number: 10022518
    Abstract: A medical tube includes a first portion, a second portion, a third portion, and a fourth portion in this order from a proximal side to a distal side thereof. The first portion has a tubular resin layer, the second portion has a tubular inner layer and outer layer, the third portion as an inner layer and outer layer, and the fourth portion has a tubular resin layer. When flexural rigidity of the first portion, the second portion, the third portion, and the fourth portion is G1, G2, G3, and G4, respectively, the flexural rigidity of each portion being configured to have a relationship with each other portion based upon the following expression (1): G1>G2>G3>G4??(1).
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: July 17, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasunori Yamashita, Tooru Oota, Youichi Ito, Naoko Katou
  • Patent number: 9999761
    Abstract: The present invention is a hemostatic plug for use with Extracorporeal Membrane Oxygenation (ECMO) cannulas that allow quick access to the blood vessel as well as maintaining a sterile environment to resume ECMO, if needed. It is designed to be a universal fit for use with adult ECMO circuits. The plug consists of a hemostatic membrane, a collection chamber and a cap. The membrane is designed to allow catheter delivery of up to a 19 French diameter through the ECMO cannula. The collection chamber allows the distribution of blood pressure over a broader surface, which allows additional hemostasis in addition to the membranes. The plug is then further reinforced with a cap that provides additional hemostasis, but when removed, allows hemostatic access into the blood vessel via the ECMO cannula.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: June 19, 2018
    Assignee: Jumark Properties LLC
    Inventors: Mark Joseph, Kenneth Jose Addison
  • Patent number: 9950137
    Abstract: A guidewire device comprising: a micro-fabricated elongated outer member having an outer surface and an interior surface forming a lumen extending from a proximal end to a distal end, wherein said outer member is formed from two or more stock materials; and an inner member disposed within a portion of said lumen, and embodiments thereof.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: April 24, 2018
    Assignee: Scientia Vascular, LLC
    Inventors: John Lippert, Edward J. Snyder
  • Patent number: 9814534
    Abstract: A remote workstation for the control of percutaneous intervention devices is provided. The remote workstation includes a control system for remotely and independently controlling at least two percutaneous intervention devices. The control system includes at least one input device to control the percutaneous intervention devices. The control system controls movement of at least one of the percutaneous intervention devices along at least two degrees of freedom. The remote workstation also includes a graphical user interface for displaying icons representative of the operational status of each of the percutaneous intervention devices.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: November 14, 2017
    Assignee: CORINDUS, INC.
    Inventors: Tal Wenderow, Thomas Bromander, David Handler
  • Patent number: 9808598
    Abstract: A flexible tip dilator is disclosed. The flexible tip dilator includes a hollow elongated tubular member with a proximal region and a tapered distal region. The tapered distal region has three regions with a first region made from at least a first material but not a second material and a third region made from at least the second material but not the first material. The second region is includes both the first and second materials overlapping one another.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: November 7, 2017
    Assignee: TELEFLEX MEDICAL INCORPORATED
    Inventors: Christopher N. Korkuch, Allen R. Mantz
  • Patent number: 9723971
    Abstract: Obtaining a surface image captured by an endoscope inserted in a tubular organ associated with a surrounding blood vessel and representing an inner surface of a wall of the organ, generating, from a three-dimensional image representing a three-dimensional area including the organ, an adjacent blood vessel image depicting a portion of the blood vessel adjacent to the wall from a viewpoint in the three-dimensional image corresponding the viewpoint of the surface image, generating, from a three-dimensional image representing a three-dimensional area including a surrounding area of the organ, a surrounding blood vessel image depicting the blood vessel from a viewpoint in the three-dimensional image corresponding the viewpoint of the surface image, and causing the surface image, adjacent blood vessel image, and surrounding blood vessel image to be displayed in this order on a display unit.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: August 8, 2017
    Assignee: FUJIFILM Corporation
    Inventor: Yoshinori Itai
  • Patent number: 9625386
    Abstract: An imaging system includes: a first lighting device for irradiating an imaging target object with visible light; a second lighting device for irradiating the imaging target object with near-infrared light; and an image sensor for photodetecting visible light caused by the visible light and coming from the imaging target object and fluorescence caused by the near-infrared light and coming from the imaging target object during a predetermined shutter open period every frame of a predetermined period. The image sensor outputs photodetection signals corresponding to photodetection amounts of the visible light and the fluorescence. The imaging system also includes a controller that generates a composite image of a visible image and a fluorescence image based on the photodetection signals, and has a lighting controller that turns on the second lighting device with optical power corresponding to the shutter open period in synchronism with the shutter open period.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: April 18, 2017
    Assignees: IWASAKI ELECTRIC CO., LTD., KOCHI UNIVERSITY
    Inventors: Mitsuyuki Hatanaka, Takashi Sato, Nozomu Kajiwara, Takaaki Komiya, Takayuki Sato
  • Patent number: 9522073
    Abstract: An endovascular stent graft delivery device has portion to remain outside a patient in use and a proximal portion to be introduced into a patient. The proximal portion has a dilator at the proximal end and a length extending module is fastened to the dilator and extends proximally. The length extending module has a proximal end which in use extends out of the patient. The dilator has a dilator marker and the length extending module has a first and second marker at the distal and proximal ends of the length extending module. The first marker and the second marker are at the same relative circumferential position on the length extending module so that the rotational position of the elongate body within the patient can be determined.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: December 20, 2016
    Assignee: Cook Medical Technologies LLC
    Inventors: Piotr Miroslaw Kasprzak, Werner Ducke, Blayne A. Roeder
  • Patent number: 9445745
    Abstract: A medical tool includes a location sensor at a distal end. While the tool is being maneuvered to a desired region of interest, a control unit records a first location reading obtained according to an output from the sensor when requested by a user, indicative of when a patient's anatomy constrains free movement of the tool in at least one degree of freedom. Once the tool has reached the region of interest, the control unit records a second location reading according to the sensor output indicative of a current location. A relaxation shape of the tool forms a shape constraint on the tool shape reconstruction. The control unit determines a reconstruction representing the current shape of the tool based on the positional constraints and the shape constraint. The reconstruction is graphically superimposed on an image of the region of interest.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: September 20, 2016
    Assignee: MediGuide Ltd.
    Inventor: Amit Cohen
  • Patent number: 9421397
    Abstract: Methods and systems for automated treatment planning for radiation therapy are disclosed. Such methods and systems may be useful for treatment planning for intensity-modulate radiotherapy (IMRT). Also provided are user interfaces for automated radiation therapy treatment planning.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: August 23, 2016
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Thomas G. Purdie, Michael B. Sharpe
  • Patent number: 9402978
    Abstract: A guidewire includes a wire body having a first wire arranged on a distal end side and a second wire arranged on a proximal end side of the first wire. A proximal end surface of the first wire and a distal end surface of the second wire are joined to each other to form a joint portion. An outer member is arranged on an outer peripheral side of the wire body and forms a tubular shape which covers the wire body at least from a distal end portion of the first wire to the joint portion. An inner member is arranged between an outer peripheral portion of the wire body and an inner peripheral portion of the outer member and covers the joint portion. The inner member is an inner coil formed by winding a wire for the inner member into a coil shape.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 2, 2016
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Hideo Sato
  • Patent number: 9314311
    Abstract: A remote workstation for the control of percutaneous intervention devices is provided. The remote workstation includes a control system for remotely and independently controlling at least two percutaneous intervention devices. The control system includes at least one input device to control the percutaneous intervention devices. The control system controls movement of at least one of the percutaneous intervention devices along at least two degrees of freedom. The remote workstation also includes a graphical user interface for displaying icons representative of the operational status of each of the percutaneous intervention devices.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: April 19, 2016
    Assignee: CORINDUS, INC.
    Inventors: Tal Wenderow, Thomas Bromander, David Handler
  • Patent number: 9042962
    Abstract: The present invention relates to a model based positioning system that includes a positioning device having at least one transmitter configured to be in a tracking environment, e.g. inserted into a body, a receiver having a plurality of receiver elements arranged outside the tracking environment, a control unit configured to measure amplitude and/or phase information of a signal transmitted from the at least one transmitter and received at each receiving element, and a memory unit M for storing a model for each receiving element. The control unit is also configured to estimate the position P of the positioning device by comparing the model for each receiving element with the measured received signal for each receiving element.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: May 26, 2015
    Assignee: MICROPOS MEDICAL AB
    Inventors: Roman Iustin, Johan Linder, Erik Isberg, Tomas Gustafsson, Bo Lennernäs
  • Publication number: 20150112195
    Abstract: Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about ?15° C. to about ?30° C. for freezing human tissue at the therapy site. Cerebral medical procedures include inter alia employing a local ice ball for sealing a bleeding rupture in an arterial wall in the case of a stroke hemorrhage, employing a local ice ball for mapping electrical disorder foci in a brain, for example, epileptic foci, and the like.
    Type: Application
    Filed: October 10, 2014
    Publication date: April 23, 2015
    Inventors: Abraham BERGER, Avri HAZAN
  • Patent number: 9002089
    Abstract: A method of registering a 4D contrast enhanced image data set, wherein the 4D contrast enhanced image data set includes image data of the same volume of interest acquired at different timeframes with changing contrast enhancement, the volume of interest includes moving structure, and the different timeframes correspond to a predetermined motion phase of interest in different motion cycles of the moving structure, the method, comprising: registering image data corresponding to a plurality of the different timeframes with reference image from one of the timeframes.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: April 7, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Michael Grass, Alfonso Agatino Isola
  • Publication number: 20150093337
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.
    Type: Application
    Filed: December 4, 2014
    Publication date: April 2, 2015
    Inventor: Lixiao Wang
  • Publication number: 20150094576
    Abstract: A system for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid to a patient is provided. The system includes an integrated compressed gas unit having an inlet port to which at least one compressed gas cylinder is selectively connected and an outlet port in communication with the inlet port. The integrated compressed gas unit also includes a regulator valve assembly positioned between the outlet port and the inlet port, wherein the regulator valve assembly includes a press button actuator and regulator adjustment dial. The system also includes a flow control system delivering the fluid in precisely controlled amounts.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 2, 2015
    Inventors: Frank Levy, Kimberley Levy
  • Patent number: 8989847
    Abstract: Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: March 24, 2015
    Assignee: Board Of Regents Of The University Of Texas System
    Inventors: Kristen Adams, Ruchi Sharma, John C. Rasmussen, Eva M. Sevick-Muraca
  • Patent number: 8983577
    Abstract: The present invention relates to a system for determining the orientation of a catheter (2). The system comprises a catheter (2), an asymmetric marker (11) attached to the catheter (2), and an imaging unit (25) for generating a projection image of the asymmetric marker (11), wherein the imaging unit (25) comprises a radiation source for generating radiation for projecting the asymmetric marker (11) in a projection plane and a detection unit for generating the projection image of the asymmetric marker (11) projected in the projection plane. The system comprises further an orientation determination unit for determining the orientation of the asymmetric marker (11) from the projection image of the asymmetric marker (11) and for determining the orientation of the catheter (2) from the determined orientation of the asymmetric marker (11). The asymmetric marker (11) is adapted such that the orientation of the asymmetric marker (11) is determinable from the projection image of the asymmetric marker (11) alone.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: March 17, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Eberhard Sebastian Hansis, Michael Grass
  • Publication number: 20150073274
    Abstract: A medical fluid injection system may include a powered injector and a fluid reservoir that contains a simulated contrast medium. The simulated contrast medium may exhibit a fluid flow property substantially equal to that of an active contrast medium but be devoid of any active contrast agent that provides contrast during diagnostic imaging. During operation, a syringe in the powered injector may be filled with the simulated contrast medium and then evacuated to discharge the simulated contrast medium from the syringe. The simulated contrast medium may be used to test and evaluate the performance of the powered injector prior to use in a medical procedure without exposing personnel to an active contrast agent or creating medical waste that contains the active contrast agent.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 12, 2015
    Inventor: Sidney D. Nystrom
  • Patent number: 8971994
    Abstract: A method for displaying a position of a medical device, such as a catheter, during insertion thereof into a patient. In one example embodiment, the method includes obtaining a first set of detected position data relating to a location marker, such as a permanent magnet, then determining a possible first position thereof. A first confidence level relating to a match between the first set of detected position data and a first set of predicted position data is assigned. A determination is made whether the first confidence level meets or exceeds a first threshold. If the first confidence level meets or exceeds the first threshold, a determination is then made whether the first position of the location marker is within a first detection zone. If the first position of the location marker is within the first detection zone, the first position of the location marker is displayed.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: March 3, 2015
    Assignee: C. R. Bard, Inc.
    Inventors: Eddie K. Burnside, Shayne Messerly, Robert N. Golden, Rand W. Lee
  • Patent number: 8923953
    Abstract: A medical examination apparatus including a control unit, an image-generating modality and a controllable injection apparatus for a contrast agent is provided. The control unit is connected to an alarm signal emitter and the control unit switches the modality and the injection apparatus to a safe mode as a function of an alarm signal.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: December 30, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Stefan Assman, Björn Heismann, Reto Merges, Markus Schmidt, Sebastian Schmidt, Kera Westphal
  • Publication number: 20140343418
    Abstract: Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.
    Type: Application
    Filed: May 29, 2014
    Publication date: November 20, 2014
    Applicant: Bracco Diagnostics Inc.
    Inventors: Charles R. Quirico, Ernest Balestracci, Rolf E. Swenson, Daniel D. Darst, Eric J. Krause, Vishal N. Lokhande, Jacob S. Childs
  • Patent number: 8855746
    Abstract: An endoscopic medical tool is endoscopically inserted into a body cavity in order to eject a member into the body cavity, and includes: a flexible sheath having an inner cavity; an elastically deformable stopper which is provided projecting out toward the inner cavity in a distal end portion of the sheath, and prevents the member which has been loaded inside the sheath from falling out of the sheath; and a pusher which is inserted into the sheath in a freely advancing and retracting manner, and which pushes out and ejects the member from the sheath. In the endoscopic medical tool, the stopper is formed in only a partial region of the inner cavity so that the stopper does not continuously formed over the entire circumference of the inner cavity.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: October 7, 2014
    Assignee: Olympus Medical Systems Corp.
    Inventor: Masaru Yuasa
  • Patent number: 8855747
    Abstract: Embodiments include a fiducial deployment system including a needle and at least two adjacent and releasably-engaged fiducials retained within a lumen of the needle by engagement with each other and/or by engagement with a pusher element. A fiducial may include one or more mechanical engagement structures that interengage with and/or are rupturably attached to one or more adjacent fiducials. The needle, which may include echogenic enhancements, may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. A variety of releasably-engaged fiducials are disclosed, as are methods for use.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: October 7, 2014
    Assignee: Cook Medical Technologies LLC
    Inventors: Mark Murray, Triona Campbell, Vincent McHugo, Michael Clancy, John Neilan
  • Publication number: 20140276042
    Abstract: An integrated catheter and powered injector system includes a pump housed in a self-contained unit, a contrast media supply removably connected to the pump by a fluid supply line, an extension line removably connecting an arterial catheter to the pump, and a control device sending user control signals to the pump. The pump comprises a motorized pump drive sub-system operating the pump, and a battery electrically connected to and powering the pump drive sub-system. In response to signals received from the control device, the pump drive sub-system drives the pump to draw contrast media fluid from the supply into the pump through the fluid supply line and inject the contrast media fluid from the output of the pump through the extension line and into the arterial catheter at a controlled flow rate and/or pressure.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: SYNTHEON, LLC
    Inventors: KEVIN W. SMITH, THOMAS O. BALES, JR., KOREY KLINE, MATTHEW A. PALMER, SEAN McBRAYER, DEREK DEE DEVILLE, ERIC PETERSEN
  • Patent number: 8821476
    Abstract: Devices and methods are described herein for engraftment of stem cells into a pancreas using an endovascular approach. Targeted intra-arterial injection of stem cells selectively in a splenic artery can achieve engraftment of insulin producing cells in the tail of the pancreas with high efficiency and without systemic circulation of these cells to other organs. In one embodiment, a catheter device includes expandable occlusion elements in the form of inflatable balloons that can be used to isolate a proximal and distal end of a pancreatic portion of the splenic artery. In another embodiment, the occlusion elements include a filter element instead of a balloon. In some embodiments, targeted delivery of stem cells to the pancreatic tail can be achieved for treatment of, for example, diabetes. In some embodiments, an arterial section of the splenic artery can be isolated for selective perfusion of therapeutic cells/drugs to the tail of the pancreas.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: September 2, 2014
    Assignee: RenovoRx, Inc.
    Inventors: Ramtin Agah, Kamran Najmabadi
  • Publication number: 20140236005
    Abstract: A method of imaging a blood vessel includes delivering a bubble-based contrast agent within the vessel and positioning at least one ultrasound device in the vicinity of the bubble-based contrast agent within the vessel. A first burst of low-frequency ultrasound energy can be delivered to excite the bubble-based contrast agent into oscillation within the vessel, and a second burst of high-frequency ultrasound energy can be delivered at the excited bubble-based contrast agent. A return signal from the burst of high-frequency ultrasound energy can be received and processed to obtain one or more images.
    Type: Application
    Filed: August 24, 2012
    Publication date: August 21, 2014
    Applicant: University of Pittsburgh-Of the Commonwealth Systems of Higher Education
    Inventors: Xucai Chen, Francois T.H. Yu, Flordeliza S. Villanueva
  • Patent number: 8734366
    Abstract: The invention provides a method for replacing a first introducer, whose distal end is inside a vessel and whose proximal end is outside the skin of a patient, with a second introducer. The method comprises the steps of inserting a guide rod into the first introducer, removing the first introducer, passing the second introducer over the guide rod, and removing the guide rod. The guide rod to be used according to the method has preferably a flexible distal portion with a blunt distal end and a stiff proximal portion with a tapered proximal end.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: May 27, 2014
    Assignee: Radi Medical Systems AB
    Inventors: Per Egnelöv, Fredrik Preinitz, Lars Tenerz
  • Publication number: 20140121514
    Abstract: Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 1, 2014
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Kristen ADAMS, Ruchi SHARMA, John C. RASMUSSEN, Eva M. SEVICK-MURACA
  • Patent number: 8706198
    Abstract: A catheter device comprising a chamber containing an opacity enhancing substance is disclosed. The opacity enhancing substance is in a dried or semi-dried form within the chamber of the device. Release of a liquid into the chamber suspends the substance and forms an opacity enhancing solution that is released into the lumen of the device in order to enhance the opacity of the device for imaging.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: April 22, 2014
    Assignee: Quali-Med GmbH
    Inventor: Eric K. Mangiardi
  • Patent number: 8694077
    Abstract: An apparatus for targeting a desired target site on a body tissue that separates a first body cavity from a second body cavity of a patient includes a catheter having a longitudinally extending catheter lumen and adapted to provide access to the first body cavity. A framing member has a collapsed condition in which the framing member is adapted for insertion into the first body cavity through the catheter lumen and an expanded condition in which the framing member is adapted for placement within the first body cavity. The framing member has a framing member body. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. At least one target pathway is attached to at least one target point. At least a portion of the target pathway extends through the catheter lumen. The target pathway is substantially spaced apart from the framing member body. A method of using the apparatus is also described.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: April 8, 2014
    Assignee: The Cleveland Clinic Foundation
    Inventor: Samir Kapadia
  • Patent number: 8670818
    Abstract: A marker delivery device is configured for deploying a tissue marker. The marker delivery device includes a handle having a chamber, and a cannula. According to one aspect, the cannula has a flexible portion formed by a slot arrangement having of a plurality of spaced-apart substantially parallel peripheral slots extending through the side wall of the cannula to the lumen. A marker introducer rod is movably disposed in the lumen of the cannula for deploying the mark, and has a flexible region that corresponds to the flexible portion of the cannula. According to another aspect, a retraction mechanism is mounted to the handle and is configured to facilitate a complete retraction of both the cannula and the marker introducer rod into the chamber of the housing of the handle upon an actuation of the retraction mechanism.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: March 11, 2014
    Assignee: C. R. Bard, Inc.
    Inventors: Himanshu Ranpura, Chad C. Van Liere
  • Publication number: 20140051997
    Abstract: Catheters for occluding, visualizing, irrigating, evacuating, and delivering agents to a treatment area are disclosed. The catheters comprise a catheter body comprising five lumens, first and second occlusion balloons coupled to the catheter body, an optional space-occupying balloon coupled to the catheter body and disposed between the first and second occlusion balloons, and an optional visualization means that enables visualization between the first and second occlusion balloons. Methods for using these catheters are also disclosed. A method comprises inflating the first and second occlusion balloons, inflating the space-occupying balloon, allowing fluid to exit via an evacuation lumen, optionally irrigating or aspirating to facilitate fluid exit via said lumen, and delivering an agent to a treatment area via the agent lumen.
    Type: Application
    Filed: February 8, 2013
    Publication date: February 20, 2014
    Applicant: ADVANCED CATHETER THERAPIES
    Inventor: ADVANCED CATHETER THERAPIES
  • Patent number: 8655798
    Abstract: A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: February 18, 2014
    Assignee: University of Virginia Patent Foundation
    Inventors: Joseph A. C. Humphrey, George T. Gillies
  • Patent number: 8649847
    Abstract: A biopsy needle has a central axis and includes one or more sensing regions, each sensing region formed by a plurality of sensing optical fibers located over a particular extent of said central axis and inside the outer shell of the needle. The sensing optical fibers are coupled to a wavelength interrogator. A steerable catheter has a central axis and outer shell, the outer shell coupled to a plurality of optical fibers in sensing regions and actuation regions, the sensing regions formed over particular extents of the central axis by bonding gratings to the inner surface of the outer shell, and the actuation regions formed by coupling optical energy into shape memory alloys bonded to the outer shell.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: February 11, 2014
    Assignee: Intelligent Fiber Optic Systems, Inc.
    Inventors: Yong-Lae Park, Richard James Black, Behzad Moslehi, Mark R. Cutkosky, Santhi Elayaperumal, Bruce Daniel, Alan Yeung, Vahid Sotoudeh
  • Patent number: 8615287
    Abstract: Methods and systems are disclosed for determining information about a position of an object within a distribution of materials having different complex conductivities. The method includes: (i) causing current to flow in the distribution; (ii) measuring an electrical signal at each of multiple locations in the distribution of materials in response to the current flow; (iii) providing spatial information about the distribution of materials with respect to a first reference frame, the spatial information indicative of regions of different complex conductivity in the distribution of materials; and (iv) determining the position of the object with respect to the spatial information about the distribution of materials based on measured electrical signals and the spatial information. In certain embodiments, the object is a catheter inserted into a patients heart cavity for cardiac mapping.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: December 24, 2013
    Assignee: Rhythmia Medical, Inc.
    Inventors: Doron Harlev, Adam Pidlisecky
  • Patent number: 8611989
    Abstract: A method of generating an image of a segment of a lumen structure comprises acquiring volumetric image data that comprises image data representative of a longitudinal segment of a lumen structure, extracting the segment of lumen structure from the volumetric image, calculating a thickness of planar MPR slab that at least encompasses the longitudinal segment of lumen structure, and rendering a planar MPR slab image based on the thickness and the volumetric image data.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: December 17, 2013
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Colin Roberts
  • Patent number: 8610022
    Abstract: Methods of using the device for conducting business transactions are also included. An impedance spectroscopy system for monitoring ischemic mucosal damage in hollow viscous organs comprises a sensor catheter and an impedance spectrometer for electrically driving the catheter to obtain a complex tissue impedance spectrum. Once the catheter is in place in one of a patient's hollow viscous organs, the impedance spectrometer obtains the complex impedance spectrum by causing two electrodes in the tip of the catheter to inject a current into the mucosal tissue at different frequencies, while two other electrodes measure the resulting voltages. A pattern recognition system is then used to analyze the complex impedance spectrum and to quantify the severity of the mucosal injury. Alternatively, the complex impedance spectrum can be appropriately plotted against the spectrum of normal tissue, allowing for a visual comparison by trained personnel.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: December 17, 2013
    Inventor: Emilio Sacristan Rock
  • Patent number: 8600479
    Abstract: A catheter system adapted for navigating, guiding and implanting a catheter or a plurality of catheters in a spatially-defined implantation within the tissue of a patient is provided. The system can include a tissue navigation system and a probe to inform the navigation system to guide emplacement of the catheters within a target tissue. The probe can provide images, such as fiberoptic visual images, or ultrasound images, or can provide radiolocation data, to guide the catheter emplacement. The catheters supply a pressurized liquid including a bioactive agent, such as can be used in the treatment of cancer, for example 123I- or 125I-IUDR. The system and methods provided can be used in the treatment of locally advanced tumors, such as cancers of the brain, head or neck, esophagus, prostate, ovary, liver, pancreas, bladder or rectum.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: December 3, 2013
    Assignee: Peak Biosciences, Inc.
    Inventors: William D. Dalke, Kevin Lillehei, Thomas A. Jellison, Michael J. Gerber, James E. Matsuura, Stephen L Warren
  • Publication number: 20130317359
    Abstract: This disclosure provides systems and methods for measuring fluid flow in a vasculature system of a patient. Some systems may include an injection system configured to inject a bolus of fluid into a vessel of a patient. Some systems may include a measurement engine configured to monitor the bolus of fluid in the vessel using measurement data generated by an intravascular measuring device. The measurement engine may determine a travel distance of the bolus of fluid and an elapsed time during which the bolus of fluid traversed the travel distance based on the measurement data. A fluid flow rate (e.g., velocity, volumetric flow) of the vessel may be calculated using the travel distance and the elapsed time.
    Type: Application
    Filed: May 24, 2013
    Publication date: November 28, 2013
    Inventors: Robert F. Wilson, Edward R. Miller, Sidney Donald Nystrom, Kendall R. Waters
  • Publication number: 20130281850
    Abstract: An introducer having a dilator positioned in a sheath is inserted into a first artery and, thereafter, only the dilator tube is drawn out of the first artery and the sheath while the sheath remains in the first artery. A diagnostic instrument having an outer diameter smaller than a maximum outer diameter permitting insertion into the sheath tube is inserted into the second artery, and a stenosis of the second artery is diagnosed. While keeping the sheath indwelling in the first artery, a therapeutic instrument or a catheter permitting the therapeutic instrument to be inserted therein, which therapeutic instrument or catheter has a maximum outer diameter permitting insertion into the sheath tube, is inserted into the second artery, and the second artery is treated.
    Type: Application
    Filed: April 19, 2013
    Publication date: October 24, 2013
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Naofumi OKAJIMA, Ryo Okamura
  • Patent number: 8560052
    Abstract: Echogenic medical devices, methods of fabrication and methods of use are disclosed. The device can be adapted to be inserted into a patient. The echogenic construction can be incorporated into the device at the time of fabrication providing acoustic impedance different from that of the surrounding biological tissue or fluid. The medical device is designed for use with an ultrasound imaging system to provide real-time location of the insertion and guidance at the time the device is implanted in a patient, such as in brachytherapy. Following placement of the device the position can be evaluated over time to insure the device remains in proper alignment and functional. Furthermore, the device is designed to incorporate a spacer element at one or both ends to provide separation between radioactive elements.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: October 15, 2013
    Assignee: Core Oncology, Inc.
    Inventor: Stanley L. Mills