Intravascular Patents (Class 600/467)
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Publication number: 20100249605Abstract: Harmonic capacitive micromachined ultrasonic transducer (“cMUT”) devices and fabrication methods are provided. In a preferred embodiment, a harmonic cMUT device generally comprises a membrane having a non-uniform mass distribution. A mass load positioned along the membrane can be utilized to alter the mass distribution of the membrane. The mass load can be a part of the membrane and formed of the same material or a different material as the membrane. The mass load can be positioned to correspond with a vibration mode of the membrane, and also to adjust or shift a vibration mode of the membrane. The mass load can also be positioned at predetermined locations along the membrane to control the harmonic vibrations of the membrane. A cMUT can also comprise a cavity defined by the membrane, a first electrode proximate the membrane, and a second electrode proximate a substrate. Other embodiments are also claimed and described.Type: ApplicationFiled: November 1, 2009Publication date: September 30, 2010Applicant: Georgia Tech Research CorporationInventor: F. Levent Degertekin
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Publication number: 20100249604Abstract: An imaging core, that is configured and arranged for insertion into a catheter, includes a mirror disposed at a distal end of a rotatable driveshaft; a motor coupled to the driveshaft and including a rotatable magnet and at least two magnetic field windings disposed around at least a portion of the magnet on a rigid slotted material; and at least one fixed transducer positioned between the motor and the rotatable mirror. The driveshaft extends through an aperture in the magnet to allow passage of the driveshaft through the at least one transducer to the rotatable mirror. At least one transducer conductor is electrically coupled to the at least one transducer and in electrical communication with the proximal end of the catheter. At least one motor conductor is electrically coupled to the magnetic field windings and in electrical communication with the proximal end of the catheter.Type: ApplicationFiled: March 31, 2009Publication date: September 30, 2010Applicant: Boston Scientific CorporationInventors: Roger N. Hastings, Michael J. Pikus, Tat-Jin Teo, Leonard B. Richardson, Kevin D. Edmunds
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Publication number: 20100249602Abstract: An ultrasound catheter housing with electromagnetic shielding properties and methods of manufacturing is provided. The ultrasound catheter housing comprises a an inner thin wall polymer tube extruded using an ultrasonically transparent polymer, a thin metalized layer deposited on the outer surface of the inner tube, and an outer thin wall polymer tube, which may be the same or a different ultrasonically transparent material. In another embodiment an ultrasound catheter comprising the ultrasound catheter housing is provided.Type: ApplicationFiled: March 25, 2009Publication date: September 30, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Donald Joseph Buckley, Douglas Glenn Wildes, Warren Lee, Weston Blaine Griffin
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Publication number: 20100249603Abstract: A catheter assembly for an intravascular ultrasound system includes an imaging core configured and arranged for inserting into a distal end of a lumen of a catheter. The imaging core includes at least one transducer mounted to a driveshaft and configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. A motor is coupled to the driveshaft between the one or more transducers and the transformer. The motor includes a rotatable magnet and at least two magnetic field windings disposed around at least a portion of the magnet.Type: ApplicationFiled: March 31, 2009Publication date: September 30, 2010Applicant: Boston Scientific SciMed, Inc.Inventors: Roger N. Hastings, Michael J. Pikus, Tat-Jin Teo, Kevin D. Edmunds
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Patent number: 7798966Abstract: An ultrasonic diagnostic apparatus including: an ultrasonic observation device that transmits and receives an ultrasonic wave by an ultrasonic transducer arranged on a tip end of a probe, and that acquires a plurality of two-dimensional ultrasonic tomographic images for a subject in a living body; a position data calculator that detects information indicating a reference position of each of the two-dimensional ultrasonic tomographic images and an orientation of a tomographic plane of the each two-dimensional ultrasonic tomographic image; and an image processor is provided. The image processor generates a band-shaped longitudinal image including a curved plane along a moving path of the ultrasonic transducer.Type: GrantFiled: October 14, 2004Date of Patent: September 21, 2010Assignee: Olympus CorporationInventors: Tomonao Kawashima, Shun Yokoi
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Patent number: 7774933Abstract: An ultrasonic catheter is manufactured by providing an inner tube having an inner diameter sufficient to accommodate a guidewire, and mounting a tubular ultrasound radiating member around a distal region of the inner tube. Two electrical conductors are positioned along the inner tube, such that one of the electrical conductors contacts an inner side of the ultrasound radiating member while the other electrical conductor contacts an outer side of the ultrasound radiating member. An outer tube is then concentrically translated over the inner tube and the ultrasound radiating member, and radially shrunken onto the inner tube.Type: GrantFiled: May 4, 2006Date of Patent: August 17, 2010Assignee: Ekos CorporationInventors: Richard R. Wilson, Tim Abrahamson, Leonard R. Oliver
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Publication number: 20100198056Abstract: Described herein are devices, methods and kits for assessing and/or enhancing the accessibility of a subvalvular space of a heart, accessing the subvalvular space of the heart (e.g., to provide access for one or more other devices), and/or positioning one or more devices in the subvalvular space of the heart. The devices described herein may, for example, comprise catheters that may be used to manipulate one or more chordae tendineae, diagnostic catheters having different sizes and/or shapes (e.g., different curvatures), guide catheters having different sizes and/or shapes (e.g., different curvatures), and visualization catheters. In some variations, the devices, methods, and/or kits may be used to visualize a target site, such as a subannular groove of a heart valve. In certain variations, the devices, methods, and/or kits may be used to manipulate chordae tendineae to provide additional space in a ventricle of a heart (e.g., enhancing the accessibility of the ventricle).Type: ApplicationFiled: January 19, 2010Publication date: August 5, 2010Inventors: Mariel Fabro, John To
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Patent number: 7762954Abstract: An intravascular ultrasonic imaging catheter is provided with a flexible circuit electrically coupled to a transducer array mounted on the distal end of the catheter, a portion of the flexible circuit being helically wound about the catheter in order to enhance the flexibility of the circuit. The catheter may be a balloon catheter which is also provided with a stent mounted on the balloon, the stent carrying one or more drugs designed to be eluted or washed into a patient's blood stream after the stent has been delivered, by a the balloon catheter, into a target area within the patient's vascular system.Type: GrantFiled: April 28, 2006Date of Patent: July 27, 2010Assignee: Volcano CorporationInventors: Elvin Nix, William Howes, Robert Dickinson, Stephan Wnendt
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Publication number: 20100179434Abstract: A catheter assembly for an intravascular ultrasound system includes a catheter and an imaging core disposed in the catheter. The imaging core includes a rotatable driveshaft, at least one light source, and at least one transducer. The at least one light source is disposed at a distal end of the rotatable driveshaft. The at least one light source is configured and arranged for rotating with the driveshaft and also for transforming applied electrical signals to light for illuminating an object in proximity to the catheter. The at least one transducer is also disposed at the distal end of the rotatable driveshaft. The at least one transducer is configured and arranged for rotating with the driveshaft. The at least one transducer is configured and arranged for receiving acoustic signals generated by the object in response to illumination of the object by the light emitted from the at least one light source.Type: ApplicationFiled: January 9, 2009Publication date: July 15, 2010Applicant: Boston Scientific SciMed, Inc.Inventor: Peter Thornton
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Patent number: 7749168Abstract: Medical examination and/or treatment system having a catheter (1) with a sensor (3, 4) connected to an image recording system, said sensor being connected to an image processing unit (24, 25) for evaluating the sensor signals recorded in an examination area, a display unit (26) for displaying the images (12) of the image processing unit (24, 25) and a means for detecting the position and/or orientation of the catheter tip, whereby the system can generate three-dimensional images from the two-dimensional images (12) of the image recording system based on the detected position and/or direction of the catheter tip.Type: GrantFiled: November 15, 2004Date of Patent: July 6, 2010Assignee: Siemens AktiengesellschaftInventors: Michael Maschke, Norbert Rahn
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Patent number: 7747047Abstract: A method for planning left atrial appendage (LAA) occlusion for a patient includes obtaining acquisition data from a medical imaging system, and generating a 3D model of the left atrium of the patient. One or more left atrial anatomical landmarks are identified on the 3D model, and saved views of the 3D model are registered on an interventional system. One or more of the registered saved views are visualized with the interventional system.Type: GrantFiled: May 7, 2003Date of Patent: June 29, 2010Assignees: GE Medical Systems Global Technology Company, LLCInventors: Darin R. Okerlund, Jasbir S. Sra, Melissa L. Vass, Shankara B. Reddy
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Publication number: 20100160788Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.Type: ApplicationFiled: December 19, 2008Publication date: June 24, 2010Applicant: Volcano CorporationInventors: Stephen Charles Davies, Norman Hossack, Peter Howard Smith
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Patent number: 7736317Abstract: An ultrasound transducer array (408) includes at least one transducer element (412) having a first (604) and second (606) portions separated by an acoustical discontinuity (520). The first portion (604) has the desired length to form a half-wave k31 resonance, while the second portion (606) has a resonant length for an undesired very low frequency out-of-band k31 resonance. The thickness of the transducer element (412) is designed for k33 half-resonance. Given the design, the transducer element (412) can operate and provide for both forward-looking (514) and side looking (512) elevation apertures. A method is also disclosed for using the disclosed ultrasound transducer (412) in ultrasound imaging.Type: GrantFiled: September 13, 2002Date of Patent: June 15, 2010Assignee: Volcano CorporationInventors: Douglas N. Stephens, Matthew O'Donnell
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Patent number: 7717853Abstract: A method for delivering ultrasound energy to a patient's intracranial space involves forming at least one hole in the patient's skull, advancing at least one ultrasound delivery device at least partway through the hole(s), and transmitting ultrasound energy from the ultrasound delivery device(s). According to various embodiments, ultrasound delivery devices may be advanced into the epidural space, one or both ventricles and/or an intracerebral space of the patient's brain. In alternative embodiments, one or multiple holes may be formed in the skull, and any number of ultrasound delivery devices may be used. Intracranial ultrasound delivery may be used in diagnostic or therapeutic treatment of ischemic stroke, head trauma, atherosclerosis, perfusion disorders and other acute or chronic neurological conditions.Type: GrantFiled: August 15, 2005Date of Patent: May 18, 2010Inventor: Henry Nita
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Patent number: 7704210Abstract: Device for removing a complete vascular occlusion using a CTO catheter, at the distal end of which are disposed stretching tongs and IVUS monitoring, whereby the CTO catheter is combined with an IVUS catheter to form an integrated unit.Type: GrantFiled: March 29, 2005Date of Patent: April 27, 2010Assignee: Siemens AktiengesellschaftInventor: Michael Maschke
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Patent number: 7706854Abstract: In order to improve the quality of cross-sectional images, which have been recorded along a longitudinal axis of a vessel of a body, it is proposed to add successive cross-sectional images to an overall cross-sectional image. Artifacts in the cross-sectional images are hereby weakened and pathological structures to be detected are high-lighted.Type: GrantFiled: April 25, 2006Date of Patent: April 27, 2010Assignee: Siemens AktiengesellschaftInventors: Martin Kleen, Marcus Pfister
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Publication number: 20100094125Abstract: A system and method for recording and depicting ultrasound images of a moving object are disclosed. In a preferred embodiment, ultrasound images are acquired as the field of view of an ultrasound probe is advanced across the tissues of interest during a resting period between periods of relatively large-scale heart cycle motion. A series of images acquired during a particular resting period may be represented as a three-dimensional volume image, and the comparison of volume images from adjacent cardiac resting periods enables three-dimensional volume image modulation analysis which may be presented for a user as a moving volume image of the objects of interest within the field of view.Type: ApplicationFiled: October 9, 2009Publication date: April 15, 2010Applicant: HANSEN MEDICAL, INC.Inventors: Robert G. YOUNGE, Daniel T. WALLACE
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Patent number: 7658715Abstract: The present invention relates to a new intravascular imaging device based on a Shape Memory Alloy (SMA) actuator mechanism embedded inside an elongate member such as a guide wire or catheter. The present invention utilizes a novel SMA mechanism to provide side-looking imaging by providing movement for an ultrasound transducer element. This novel SMA actuator mechanism can be easily fabricated in micro-scale, providing an advantage over existing imaging devices because it offers the ability to miniaturize the overall size of the device, while the use of multiple transducer crystals maximizes field of view. Also disclosed are methods of using the same.Type: GrantFiled: May 2, 2006Date of Patent: February 9, 2010Assignee: Fluid MedicalInventors: Byong-Ho Park, Stephen M. Rudy
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Patent number: 7645238Abstract: A system and method for regional anesthesia using ultrasound to assist in locating the anesthetic needle are disclosed. One or more piezo-electric crystal transducers is placed either at the tip of the needle or near the tip of the needle on a stylet which is inserted into the lumen of the needle. The transducer(s) are pulsed with ultrasonic frequency, the reflected ultrasonic signals from structures are detected and converted into a digital signal and may be displayed in an oscilloscopic format to indicate anatomical structures forward to the needle and allow the medical professional to avoid errors and/or increase efficiency and accuracy. An array of transducers can be pulsed in a phased array fashion to generate a 2D image, or a single transducer can be pulsed to generate a 1D image.Type: GrantFiled: December 2, 2005Date of Patent: January 12, 2010Assignee: The Cooper Health SystemInventor: Robert Hirsh
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Patent number: 7628756Abstract: An emboli detector device receives a blood flow in a perfusion circuit. The connector-like device has a rigid plastic smooth body hermetically sealed from the blood. There is a calculated thin, but rigid window formed as part of the flow-through tubing wall to allow ultrasonic waves to interrogate the flowing blood. A dampening material is included in the ultrasound path to adjust the acoustic levels to an applicable range to monitor emboli. The device incorporates a mechanism to securely hold the transducer during operation and a sensing system for automatically informing a control system of which one of several standard perfusion circuit tubing diameters is being used. The ultrasound echoes detected by the transducer are provided to a controller which detects the emboli and provides a detection signal to warn the surgeon or other operating room personnel of the embolic event.Type: GrantFiled: March 4, 2006Date of Patent: December 8, 2009Assignee: Terumo Cardiovascular Systems CorporationInventors: Thomas G. Hacker, Brent William Allen
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Patent number: 7621874Abstract: The systems and methods described herein provide for the improved three-dimensional imaging of the an internal body lumen of a living being. A medical imaging system is provided which can include an image processing system and a medical imaging device. The medical imaging device can be insertable into the internal lumen and can include an image acquisition system configured to image the lumen and detect the position and orientation of the image acquisition system within the lumen. The image acquisition system can output the image, position and orientation data to the image processing system to be used by the processing system to generate and display a virtual three-dimensional image of the internal lumen to the user. The user can use various software tools provided by the image processing system, such as distance and area measuring tools, to interact with the image.Type: GrantFiled: December 14, 2004Date of Patent: November 24, 2009Assignee: SciMed Life Systems, Inc.Inventors: Richard Romley, Thomas C. Pham, Scott Harshman
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Patent number: 7620445Abstract: In a fluorescence tomography apparatus for obtaining fluorescence tomographic images of a region of an object to be observed: an application unit concurrently applies an ultrasonic wave and excitation light to the region so that ultrasound-modulated fluorescence is emitted from the region under the influence of the ultrasonic wave; and a first image acquisition unit acquires a fluorescence tomographic image of the region on the basis of the ultrasound-modulated fluorescence.Type: GrantFiled: January 26, 2006Date of Patent: November 17, 2009Assignee: FUJIFILM CorporationInventor: Kazuhiro Tsujita
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Patent number: 7618374Abstract: A position of an imaging plane relative to a catheter or other probe is aligned with tissue of interest. Ultrasound tissue images may be registered to the catheter position with minimal rotational ambiguity. The spatial position of an ablation catheter or other device with respect to the imaging plane is more accurately determined, allowing a physician to identify specific anatomy in the relative location of a catheter or catheters. Another alternative or additional approach to determining the position of an imaging plane is to determine the relative position of two or more catheters. A catheter associated with imaging is then moved or bent in a direction having a known spatial relationship with the imaging plane. The position of the catheter is relative to each is then determined again to determine the angle or position of the imaging plane.Type: GrantFiled: September 27, 2004Date of Patent: November 17, 2009Assignee: Siemens Medical Solutions USA, Inc.Inventors: Stephen R. Barnes, Mirsaid Bolorforosh, Vaughn R. Marian, David I. Bruce, Tim Thigpen
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Publication number: 20090275840Abstract: Devices and methods are disclosed for providing a sensing element to scan tissue and detect the presence of structures within the tissue to avoid the structures when performing a procedure on the tissue. A catheter includes a blood vessel sensing assembly and a working lumen adapted to receive a medical appliance or instrument for performing various medical procedures.Type: ApplicationFiled: March 17, 2009Publication date: November 5, 2009Inventors: Edmund J. ROSCHAK, Thomas M. KEAST, Eric J. GWERDER
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Patent number: 7613503Abstract: An imaging device such as a catheter has a plurality of infusion holes adapted to infuse liquid into the blood stream while substantially preventing radial jetting. An example imaging catheter includes an elongated member, having distal and proximal ends, an axis, a lumen along the axis, and an outer surface. Preferably, a plurality of infusion holes are defined along the axis of said elongated member between the lumen and the outer surface. The plurality of infusion holes may be tapered from the outer surface to the lumen. Further, the plurality of infusion holes may be angled outwardly toward the proximal end of the elongated member. The size, shape, spacing and configuration of the infusion holes may be varied as desired.Type: GrantFiled: August 9, 2002Date of Patent: November 3, 2009Assignee: Boston Scientific Scimed, Inc.Inventor: Mark Hamm
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Publication number: 20090253989Abstract: A multimodal intravascular analysis uses a structural intravascular analysis modality to compensate for a chemical analysis modality. Examples of structural analysis are IVUS, OCT, including optical coherence domain Reflectometry (OCDR) and optical frequency domain imaging (OFDI), and/or sonar range finding. Examples of chemical or functional analysis are optical, NIR, Raman, fluorescence and spectroscopy, thermography and reflectometry. In one example, the structural analysis is used to characterize the environment structurally, such as catheter head-vessel wall distance. This information is then used to select from two or more algorithms which are depth specific (e.g. shallow vs. deep), to achieve improved accuracy in the chemical or functional analysis.Type: ApplicationFiled: April 3, 2008Publication date: October 8, 2009Applicant: INFRAREDX, INC.Inventors: Jay D. Caplan, Huwei Tan
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Publication number: 20090221918Abstract: An electrical connector is described. In one implementation, the connector includes a female portion including one or more electrical contacts and a male portion including one or more electrical contacts. The female portion and the male portion each have a self-orientating geometry that allows the male portion to be mated with the female portion in any rotational position along 360 degrees of rotation. When mated, the electrical contacts of the female portion mate with corresponding one or more electrical contacts of the male portion to form one or more electrical connections between two electronic components.Type: ApplicationFiled: May 12, 2009Publication date: September 3, 2009Applicant: Boston Scientific SciMed, IncInventors: E. Scott Harshman, Donald Masters, Peter Thornton
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Publication number: 20090163818Abstract: The present invention provides low profile intravascular ultrasound catheters adapted to access sites within the patient's body through narrow blood vessels, e.g., the radial artery. In an embodiment, a low profile catheter comprises an catheter sheath, a short guidewire receiver attached to the distal end of the catheter sheath, and a telescope assembly at the proximal end. The catheter sheath comprises a main portion and a tapered portion for increased flexibility toward the distal end of the catheter. In one embodiment, a rotatable and translatable imaging core is received within the catheter sheath for ultrasound imaging. A short guidewire receiver is used to allow the imaging core to be advanced farther distally with respect to the distal end of the catheter. In an embodiment, the catheter sheath extends through a portion of the telescope assembly to provide enhanced support of the imaging core within the telescope assembly.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Inventors: Robert Zelenka, Daniel Okeeffe, Mikael Cars, Bruce McEvers
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Publication number: 20090156941Abstract: A catheter has a proximal end and a distal end and comprises an outer tube having a proximal end, an inner sheath slidingly received within the outer tube and extending distally from the outer tube, and a rotatable shaft extending from the proximal end of the outer tube to within the inner sheath. The rotatable shaft is axially fixed with respect to the outer tube and axially moveable within and with respect to the inner sheath. The rotatable shaft includes a proximal substantially rigid section and a distal flexible section. The catheter further includes a working element carried on the distal flexible section of the rotatable shaft.Type: ApplicationFiled: December 16, 2008Publication date: June 18, 2009Applicant: Silicon Valley Medical Instruments, Inc.Inventor: Thomas C. Moore
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Patent number: 7544166Abstract: The systems and methods described herein provide for a medical device insertable into the body of a living being having an imaging device with a layout that is adjustable from an undeployed layout, where the imaging device is insertable into the inner lumen of a medical device, to a larger deployed layout, where the imaging device preferably has a larger imaging aperture. The medical device can also include a flexible membrane coupled with or located on the distal end of the medical device. The flexible membrane can be expanded or inflated to create a spatial operating region for the deployed imaging device.Type: GrantFiled: June 3, 2005Date of Patent: June 9, 2009Assignee: SciMed Life Systems, Inc.Inventors: Jian R. Yuan, Pei Jie Cao, Richard Romley
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Patent number: 7527594Abstract: The present invention is a guide wire imaging device for vascular or non-vascular imaging utilizing optic acoustical methods, which device has a profile of less than 1 mm in diameter. The ultrasound imaging device of the invention comprises a single mode optical fiber with at least one Bragg grating, and a piezoelectric or piezo-ceramic jacket, which device may achieve omnidirectional (360°) imaging. The imaging guide wire of the invention can function as a guide wire for vascular interventions, can enable real time imaging during balloon inflation, and stent deployment, thus will provide clinical information that is not available when catheter-based imaging systems are used. The device of the invention may enable shortened total procedure times, including the fluoroscopy time, will also reduce radiation exposure to the patient and to the operator.Type: GrantFiled: October 14, 2003Date of Patent: May 5, 2009Assignee: Vascular Imaging CorporationInventors: Gil M. Vardi, Evgeni Spivak, legal representative, Victor Spivak
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Patent number: 7507205Abstract: Steerable catheters are provided including an elongated flexible member having a proximal end, a distal end and a lumen extending therebetween (i.e., between the proximal end and the distal end). A plurality of electrical cables is bundled together and positioned within the lumen of the flexible member. The cross-section of the bundle of electrical cables is substantially ovular or rectangular so as to be bendable in two approximately opposite directions. Methods of steering such a catheter within a body include advancing the catheter within a body while a first force is applied to the bundle of electrical cables to cause the distal end of the elongate flexible member to form a bend. The catheter is farther advanced within the body while a second, opposite force is applied to the bundle of electrical cables to remove the bend in the distal end.Type: GrantFiled: April 7, 2004Date of Patent: March 24, 2009Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.Inventors: Simcha Borovsky, Praveen Dala-Krishna, Charles Bryan Byrd
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Publication number: 20090069694Abstract: A coronary access catheter system simplifies the insertion of objects into distal branches of the coronary sinus. The system incorporates a real-time forward-imaging means to view the os and the branches of the coronary sinus. Preferably, the catheter uses near-infrared light as the forward-imaging means, but it could also include ultrasound or electromagnetic transducer. As the image is viewed, the catheter tip can be steered into the coronary sinus os and deflected in a tight radius bend on the distal end to navigate the short radius, right angle turns found in the coronary sinus branches. At that point, a flexible sheath can be placed over the guide catheter or objects such as guidewires can be inserted into channels of the guide catheter. The system consists of a catheter and image acquisition unit, which displays the forward image.Type: ApplicationFiled: October 2, 2008Publication date: March 12, 2009Inventors: David Amundson, H. John Hanlin, Larry Blankenship
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Patent number: 7500954Abstract: A foldable transducer array is unfolded or deployed for use, providing a larger radiating surface. While folded, the transducer array has a smaller width or volume for insertion into and withdrawal from the patient.Type: GrantFiled: September 22, 2005Date of Patent: March 10, 2009Assignee: Siemens Medical Solutions USA, Inc.Inventors: Walter T. Wilser, John Paul Mohr
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Patent number: 7493219Abstract: A method for discriminating particle groups comprises generating, by a particle analyzer, a particle characteristic distribution histogram in which the abscissa indicates respective channels for representing the characteristics of the particles, and the ordinate indicates the particle count; setting a valid area selection height in the particle characteristics distribution histogram; and generating an equivalent negative histogram based on the set height and the particle characteristic distribution histogram.Type: GrantFiled: December 27, 2007Date of Patent: February 17, 2009Assignee: Shenzhen Mindray Bio-Medical Electronics Co.Inventors: Huan Qi, Wenjun Tong
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Patent number: 7481774Abstract: The disclosed embodiments present improved catheters with physiological sensors. In one embodiment, the catheter includes, generally, a pressure transducer/electronics assembly connected to a pressure transmission catheter. The pressure transmission catheter includes a hollow tube made from a low compliance material. The distal end of the hollow tube is filled with a gel-like material or plug which acts as a barrier between the catheter liquid and the target fluid. The hollow tube is partially filled with a low viscosity liquid and is in fluid communication with the gel-like material and the pressure transducer. The pressure of the target fluid is transmitted to the liquid in the hollow tube through the gel-like material and/or the wall of the distal tip and is fluidically transmitted to the pressure transducer. The pressure transmission catheter may be inserted into a vessel lumen or into a lumen of a therapeutic or diagnostic catheter for biomedical applications.Type: GrantFiled: April 22, 2003Date of Patent: January 27, 2009Assignee: Transoma Medical, Inc.Inventors: Brian P. Brockway, Lynn M. Zwiers, Perry A. Mills, Mark J. Drexler
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Publication number: 20090024040Abstract: The present invention provides intravascular diagnostic catheters that include one or more wall-contacting/wall-approaching probes including IVUS probe elements and diagnostic systems including such catheters, for the evaluation and diagnosis of blood vessels. Also provided are intravascular catheters in which the wall-contacting/wall-approaching probes further include an optical probe element and systems including such catheters, for combined IVUS and optical analysis of a blood vessel wall.Type: ApplicationFiled: June 11, 2008Publication date: January 22, 2009Applicant: Prescient Medical, Inc.Inventor: Eduardo Ignacio Cespedes
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Publication number: 20090005675Abstract: An endovascular access and guidance system has an elongate body with a proximal end and a distal end; a non-imaging ultrasound transducer on the elongate body configured to provide in vivo non-image based ultrasound information of the vasculature of the patient; an endovascular electrogram lead on the elongate body in a position that, when the elongate body is in the vasculature, the endovascular electrogram lead electrical sensing segment provides an in vivo electrogram signal of the patient; a processor configured to receive and process a signal from the non-imaging ultrasound transducer and a signal from the endovascular electrogram lead; and an output device configured to display a result of information processed by the processor.Type: ApplicationFiled: June 26, 2008Publication date: January 1, 2009Inventors: Sorin Grunwald, Fiona Maria Sander, Wilfred J. Samson, Bradley Hill, E. Tina Cheng
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Publication number: 20080200815Abstract: Intravascular ultrasound techniques provide for intravascular imaging using contrast agents and nonlinear techniques. An ultrasound imaging device for detecting internal properties of a target body comprises an ultrasound transducer positioned at a distal end portion of a catheter, for transmitting excitation pulses and for receiving echo signals. A signal processor analyses echo signals at harmonics and/or subharmonics of the transmit frequency. The catheter may include a contrast agent delivery conduit extending along the catheter, the delivery conduit having an exit orifice proximal to the ultrasound transducer. The device may discriminate between echo signals respectively arising from interaction with tissue and from the interaction with contrast agent. The device may generate an image of the site of interest using non-linear components of the received ultrasound echo signals.Type: ApplicationFiled: August 11, 2005Publication date: August 21, 2008Applicant: Stichting Voor De Technische WetenschappenInventors: Antonius Franciscus Wilhelmus Van Der Steen, David Eric Goertz, Martin Egbert Frijlink
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Publication number: 20080167560Abstract: The present invention provides self-aligning rotational connectors. In an non-limiting embodiment, a catheter system comprises a catheter connectable to a drive unit. The catheter includes a rotator, and at least one orientating feature extending proximally from the rotator, and configured to be inserted into an orienting slot of a shaft connector of the drive unit. When the orienting feature is inserted into the slot of the shaft connector, the slot transmits torque from the shaft connector to the orientating feature, and therefore the rotator of the catheter. Electrical contacts are provided on the rotator and the shaft connector, wherein the contacts of the rotator are properly aligned with and engage the contacts of the shaft connector. Further, the shaft connector has a slopping surface that slops downward into the slot for automatically aligning the rotator rotationally with the shaft connector during insertion of the catheter into the drive unit.Type: ApplicationFiled: January 9, 2007Publication date: July 10, 2008Inventor: Peter Thornton
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Patent number: 7396332Abstract: A single transducer element that is capable of oscillation at a plurality of natural resonant frequencies may be used in an ultrasonic imaging catheter assembly including a catheter body configured to be inserted and guided through the vascular system of a living being, a lumen and a rotatable imaging core adapted to pass through the lumen, the imaging core including a flexible drive-shaft. Because the transducer element is capable of oscillation at a plurality of natural resonant frequencies, a user can switch from one frequency to another in order to improve the depth of field or resolution without having to switch out the catheter or imaging core.Type: GrantFiled: June 10, 2002Date of Patent: July 8, 2008Assignee: SciMed Life Systems, Inc.Inventors: Miriam H. Taimisto, Richard Lardner
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Publication number: 20080161696Abstract: In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.Type: ApplicationFiled: November 8, 2007Publication date: July 3, 2008Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Christopher Petersen, Toru Ohashi, Tetsuya Nakamatsu
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Patent number: 7393501Abstract: An apparatus, system and method for preventing or treating biofilm associated with catheters. A piezo-ceramic element may be attached to a catheter, and a vibration processor may be connected to the piezo-ceramic element. The vibration processor may provide electric signals that generate acoustic vibrations in the piezo-ceramic element, causing vibrations in or around the catheter. These vibrations may be particularly administered to disperse microbe colonies, thereby preventing or inhibiting formation of biofilm that may lead to infections. Vibrations may be amplified significantly due to resonance conditions in the catheter balloon, which may be powerful enough to be used to disperse microbe colonies that have grouped around the catheter or are attempting to do so.Type: GrantFiled: May 28, 2003Date of Patent: July 1, 2008Assignee: Nano Vibronix IncInventors: Jona Zumeris, Jacob Levy, Yanina Zumeris
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Publication number: 20080154137Abstract: Systems, methods and computer products for display of the inside of the coronary artery as an intravascular ultrasound (IVUS) view with separation of the lumen of the coronary, the wall of the vessel and calcified plaque. Exemplary embodiments include a cardiac volume rendering method, including obtaining intravascular ultrasound views of a blood vessel, detecting calcifications within the blood vessel, separating components of the blood vessel for display on a graphical user interface, defining several renderings of the components and displaying combinations of the several renderings on the graphical user interface.Type: ApplicationFiled: November 16, 2007Publication date: June 26, 2008Inventors: Celine Pruvot, DeAnn Marie Haas, Laurent Launay, James Donald Markvicka, Jean Louis Sablayrolles
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Publication number: 20080108937Abstract: An ultrasound catheter has an elongate flexible catheter body having a lumen extending longitudinally therethrough, and an ultrasound transmission member extending longitudinally through the lumen of the catheter body. The ultrasound transmission member has a proximal end that is coupled to a separate ultrasound generating device, and a distal end that terminates at the distal end of the catheter body, with at least a portion of the distal end of the ultrasound transmission member extending outside the lumen of the catheter body and beyond the distal end of the catheter body, and with the ultrasound transmission member directly attached to the catheter body via an attachment device.Type: ApplicationFiled: November 7, 2006Publication date: May 8, 2008Inventor: Henry Nita
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Patent number: 7364546Abstract: The present invention provides multi-functional medical catheters, systems and methods for their use. In one particular embodiment, a medical catheter (100) includes a flexible elongate body (105) having a proximal end (110) and a distal end (120). A plurality of spaced apart electrodes (130-136) are operably attached to the flexible body near the distal end. At least some of the electrodes are adapted for mapping a tissue and, in some embodiments, at least one of the electrodes is adapted for ablating a desired portion of the tissue. The catheter includes a plurality of tissue orientation detectors (140-146) disposed between at least some of the electrodes. In this manner, the medical catheter is capable of tissue mapping, tissue imaging, tissue orientation, and/or tissue treatment functions.Type: GrantFiled: March 19, 2007Date of Patent: April 29, 2008Assignee: Boston Scientific SciMed, Inc.Inventors: Dorin Panescu, David K. Swanson
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Patent number: 7359554Abstract: A system and method is provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device. In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon—i.e., a border-detection application, an extrapolation application, and an active-contour application. These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e.Type: GrantFiled: August 26, 2003Date of Patent: April 15, 2008Assignee: Cleveland Clinic FoundationInventors: Jon D. Klingensmith, D. Geoffrey Vince, Anuja Nair, Barry D. Kuban
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Patent number: 7338452Abstract: An ultrasonic diagnostic system according to the present invention has an ultrasonic transducer mounted on a catheter, an instantaneous distortion value calculator which calculates an instantaneous distortion value at the location to be evaluated in the blood vessel based on received signal representative of received reflection by the ultrasonic transducer, an analyzer which analyzes a state of the location to be evaluated using time-series data of instantaneous distortion values which are calculated at a plurality of times in a chronological sequence by the distortion value calculator, and a display which displays an analyzed result produced by the analyzer.Type: GrantFiled: May 6, 2004Date of Patent: March 4, 2008Assignee: Terumo Kabushiki KaishaInventors: Tsuyoshi Shiina, Naotaka Nitta, Hiroyuki Yagami
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Patent number: 7335180Abstract: Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Ultrasound catheter devices generally include an elongate flexible catheter body with one or more lumens, an ultrasound transmission member extending longitudinally through the catheter body lumen and a distal head coupled with the transmission member and positioned adjacent the distal end of the catheter body for disrupting occlusions. Improved features of ultrasound catheters include catheter bodies and ultrasound transmission members with increasing distal flexibility, guidewire tubes allowing contact between a guidewire and an ultrasound transmission member, distal heads with improved guidewire lumens, and torquable proximal housings for enhancing disruption of blood vessel occlusions.Type: GrantFiled: November 24, 2003Date of Patent: February 26, 2008Assignee: FlowCardia, Inc.Inventors: Henry Nita, Jeff Sarge
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Publication number: 20080009746Abstract: Devices and methods for assessing the size, shape, and topography of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the size, shape, topography, and compliance of the native heart valves to facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an assessment mechanism fixed to a distal end of the catheter. The assessment mechanism generally includes an expandable member, such as a balloon. The assessment mechanism may also include an imaging member, a physical assessment member, an electronic mapping construction, an alignment mechanism, a valvuloplasty balloon, or any combinations thereof. The methods typically comprise deploying the balloon percutaneously to a target location, expanding the balloon, and determining one or more physical parameters associated with the target location.Type: ApplicationFiled: May 24, 2006Publication date: January 10, 2008Applicant: AORTX, INC., A California CorporationInventors: David C. Forster, Brian Beckey, Brandon Walsh, Scott Heneveld