Measuring Respiratory Flow Impedance Or Lung Elasticity Patents (Class 600/533)
  • Publication number: 20110218451
    Abstract: Described herein are passive nasal device having a resistance to exhalation that is greater than the resistance to inhalation. Also described are devices, methods and systems for sensing and measuring intranasal pressure when a subject is wearing a passive nasal respiratory device that is configured to inhibit exhalation more than inhalation. Also described are adapters for nasal devices and methods of using a nasal device adapter. Adapters may be used so that a passive nasal device may be applied indirectly in communication with a subject's nose; in some variations this may allow the passive nasal device to be re-used. Also described herein are nasal devices having a billowing airflow resistor that is configured to have a greater resistance to exhalation than to inhalation.
    Type: Application
    Filed: September 15, 2009
    Publication date: September 8, 2011
    Inventors: Danny Yu-Youh Lai, Arthur Ferdinand, Michael P. Wong, Elliot Sather, Rajiv Doshi, Bryan Loomas, Toru Mino, Jonathan Patrick Summers, Arthur G. Sandoval, Jonathan Downing, Jeffrey W. Servaites, Ryan K. Pierce, Motohide Hatanaka
  • Patent number: 7967759
    Abstract: The system 10 includes an endoscopic probe 20 and an expired air sampling device 24 functionally connected to a control console 28. In use, the endoscopic probe 20 is routed through a body lumen of a patient to, for example, visualize a selected region of a patient's body. As the endoscopic probe 20 is routed through the body lumens, the expired air sampling device 24 collects expired air from the patient, generates signals indicative of patient respiratory status, and outputs the generated signals to the control console 28. The control console 28 processes the signals and monitors the respiratory status of the patient. If the respiratory status of the patient changes based on the processed signals of the expired air sampling device 24, the control console 28 may output an audible or visual alert signal.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: June 28, 2011
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Lucien Alfred Couvillon, Jr.
  • Patent number: 7942822
    Abstract: A method for use in an implantable medical device comprises the steps of monitoring respiration with an amplifier having a gain, generating a moving apneic threshold based on recent respiration cycles, accumulating differences between amplitudes of respiration cycles and the moving apnea detection threshold and comparing the accumulated differences against an apnea detection threshold to detect the onset of an episode of apnea. The method further comprises measuring respiration levels upon detecting the onset of apnea, confirming the episode of apnea based upon the respiration levels measured upon detecting the onset of apnea; and adjusting one of the gain of the amplifier and the apnea detection threshold so that the time from the detection of onset of apnea to the time of confirmation of the episode of apnea is within a predetermined time range following the detection of the onset of apnea.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: May 17, 2011
    Assignee: Pacesetter, Inc.
    Inventor: Steve Koh
  • Patent number: 7907998
    Abstract: A method of determining an impedance of at least one lung of a patient having an implanted pacemaker that comprises first and second leads and a case, the method comprising: a) using the leads and the case to acquire at least a first and a second impedance measurement responsive to impedance of the patient's chest that are at least partially independent; and b) using the impedance measurements to determine the impedance of at least one of the lungs substantially independently of impedance of the other lung.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: March 15, 2011
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventor: Shimon Arad (Abboud)
  • Publication number: 20110060237
    Abstract: Continuous measurement of respiratory impedance with very high precision is enabled by executing noise removal. An air vibration pressure by an oscillation wave obtained by frequency culling such that the oscillation wave has only frequency components left by the culling from a plurality of different frequencies, is applied by a loudspeaker 21 to the inside of an oral cavity. The pressure in the oral cavity is detected and the flow of breathing is detected. These signals obtained are Fourier-transformed by a Fourier transforming means 32 and, thereby, a spectrum is obtained. A breathing high frequency component that contributes as a noise is obtained by the extracting means 33 using a spectrum that corresponds to the frequency components culled from the result of the Fourier transformation. The breathing high frequency component is subtracted from the spectrum that corresponds to the frequency components left by the culling and, thereby, the oscillation wave component is extracted.
    Type: Application
    Filed: March 9, 2009
    Publication date: March 10, 2011
    Inventors: Hajime Kurosawa, Yoshio Shimizu, Toshiaki Hoki
  • Patent number: 7901361
    Abstract: A breathing apparatus is provided for the treatment of obstructive sleep apnea that optimizes the positive pressure to the airway of a patient. The apparatus is configured to detect flow limitations in the patient airway from an analysis of inspiratory flow waveforms. The airway pressure setting is raised, lowered or maintained depending on whether a flow limitation has been detected and on the previous actions taken by the apparatus. The apparatus may include a blower, a flow sensor, a pressure sensor, a microprocessor, a pressure controller and a nasal fitting. The apparatus is configured to increase the airway pressure when a flow limitation is detected in the airway of the patient and to decrease the airway pressure when a flow limitation is not detected.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: March 8, 2011
    Assignee: New York University
    Inventors: David M. Rapoport, Robert G. Norman
  • Patent number: 7878980
    Abstract: A gas flow diverter for increasing the turbulence of an incoming respiratory gas flow through a respiratory gas sensor is provided. The diverter is positioned at a patient or inlet end of a tube section of the sensor in order to divert the respiratory gas flow from the patient generally equally across the cross-sectional area of the tube section. The diverter can be formed integrally as a part of the sensor, or can be releasably attached to the sensor or to an adapter that is releasably connected to the inlet end of the sensor for use in situations in which the volume of the incoming respiratory gas flow from the patient is greatly reduced due to the size of the patient, i.e., when the patient is an infant.
    Type: Grant
    Filed: June 8, 2004
    Date of Patent: February 1, 2011
    Assignee: Treymed, Inc.
    Inventor: Robert H. Ricciardelli
  • Patent number: 7867172
    Abstract: A combination toothbrush and peak flow meter system for increasing the compliance of peak flow measurements in children and adults with asthma. The combination toothbrush and peak flow meter system includes a peak flow meter and a toothbrush head connected to an end of the peak flow meter.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: January 11, 2011
    Inventors: Dingane Baruti, Mary A. Dean
  • Publication number: 20100275921
    Abstract: Devices and systems provide methods of detecting a severity change in respiratory insufficiency (RI) or chronic obstructive pulmonary disease (COPD) condition of a patient. In an example embodiment, a detection monitoring device determines one or more severity change indicators based on a measure of supplied pressure or other representative measure determined by the device. The supplied pressure may optionally be determined during pressure treatment that satisfies a target ventilation. The supplied pressure or representative data may be compared to one or more thresholds that are selected to represent a change in the condition of the RI or COPD patient such as an exacerbation of a prior condition. Results of the comparisons may trigger one or more warnings or messages to notify a patient or physician of a pending change to the patient's RI or COPD condition so that the patient may more immediately seek medical attention to treat the condition.
    Type: Application
    Filed: March 31, 2010
    Publication date: November 4, 2010
    Applicant: RESMED LIMITED
    Inventors: Klaus Henry Schindhelm, David John Bassin, Glenn Richards
  • Publication number: 20100228142
    Abstract: A method for determining dynamically a respiratory feature in a spontaneously breathing patient receiving mechanical ventilatory assist comprises: modifying a level of mechanical ventilatory assist to the patient, measuring an airway pressure, detecting a change of gradient of the measured airway pressure and determining the respiratory feature based on the measured airway pressure upon detecting the change of gradient of the airway pressure. Furthermore, the method also comprises: measuring a respiratory neural drive of the patient and detecting a lowest level of the measured respiratory neural drive for determining the respiratory feature based on the detected lowest level of respiratory neural drive.
    Type: Application
    Filed: January 19, 2007
    Publication date: September 9, 2010
    Applicant: Maquet Critical Care AB
    Inventor: Christer Sinderby
  • Patent number: 7775993
    Abstract: A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: August 17, 2010
    Assignee: Medtronic, Inc.
    Inventors: Kenneth T. Heruth, Keith A. Miesel
  • Patent number: 7766840
    Abstract: An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: August 3, 2010
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jonathan Kwok, Marina Brockway, Kent Lee, Quan Ni, Yachuan Pu, Jeffrey Stahmann, Yi Zhang, Jesse Hartley
  • Publication number: 20100147305
    Abstract: The present invention refers to a system and a method for the automatic detection of the expiratory flow limitation of a subject. In an embodiment thereof the system for the automatic detection of expiratory flow limitation of a subject comprises determining the respiratory impedance of the subject comprising an imaginary component and, eventually, of a real part or, at least, by applying a forcing signal with one or more spectral components to the airway opening of a subject combined with measuring time courses of pressure and flow at the airway opening; determining at least one index linked to respiratory impedance or pressure and flow time courses; indicating the positioning of at least one index in relation to a preset threshold value.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 17, 2010
    Applicant: POLITECNICO DI MILANO
    Inventors: Raffaele Dellaca', Andrea Aliverti, Antonio Pedotti
  • Patent number: 7708697
    Abstract: Airway monitoring apparatus 30 includes a driver 6 for applying sound in the audible frequency range to the airway of a subject and a detector 7 for monitoring the response of the airway, e.g. by detecting transmitted sound signal components and/or reflected sound signal components. Variations in the detected sound signal, e.g. energy, due to attenuation of the signal, give an indication of the state of the airway, e.g. airway patency, and can be used to monitor sleep-disordered breathing events, such as apnea and hypopnea, and to provide a breathing event index, e.g. AHI. The apparatus may provide servo-control for a respiratory assist device, such as a positive airway pressure device, so as to provide an appropriate pressure level setting. It may allow for home use of such devices and for home titration. It may also assist in discriminating central and obstructive breathing events, and in providing a measure of airway resistance.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: May 4, 2010
    Assignee: Pulmosonix Pty Ltd
    Inventors: Malcolm Howard Wilkinson, Clive Andrew Ramsden, Philip John Berger, Peter Camilleri, Jacqueline Anne Wilson, Frank Samuhel
  • Patent number: 7690378
    Abstract: Methods, systems and devices are provided for monitoring respiratory disorders based on monitored factors of a photoplethysmography (PPG) signal that is representative of peripheral blood volume. The monitored factors can be respiratory effort as well as respiratory rate and/or blood oxygen saturation level. The systems and devices may or may not be implanted in a patient.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: April 6, 2010
    Assignee: Pacesetter, Inc.
    Inventor: Robert G. Turcott
  • Patent number: 7661428
    Abstract: Methods and apparatus for determining leak and respiratory airflow are disclosed. A pressure sensor (34) and a differential pressure sensor (32) have connection with a pneumotach (24) to derive instantaneous mask pressure and airflow respectively. A microcontroller (38) estimates a non-linear conductance of any leak path occurring at a mask (12) as being the low pass filtered instantaneous airflow divided by the low pass filtered square root of the instantaneous pressure. The instantaneous leak flow is then the conductance multiplied by the square root of the instantaneous pressure, and the respiratory airflow is calculated as being the instantaneous airflow minus the instantaneous leak flow. The time constants for the low pass filtering performed by the microcontroller (38) can be dynamically adjusted dependent upon sudden changes in the instantaneous leak flow.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: February 16, 2010
    Assignee: Resmed Limited
    Inventor: Michael Berthon-Jones
  • Patent number: 7603887
    Abstract: A device, a system and a process is provided for the use of a breath alcohol-measuring device (1) with improved personal identification. The breath alcohol-measuring device (1) is combined with a pulse oscillometer (4) such that the initially measured values of the complex airway resistance of a test subject are stored in an evaluating and control unit (3) connected to the breath alcohol-measuring device (1) and to the pulse oscillometer (4) and compared to subsequently measured values of a test subject. A breath alcohol measurement is released and/or a vehicle immobilizer (2) is actuated in case of agreement of stored values with subsequently measured values.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: October 20, 2009
    Assignee: Dräger Medical AG & Co. KG
    Inventor: Mladen Schlichte
  • Patent number: 7588543
    Abstract: A method of creating a non-invasive predictor of both physiologic and imposed patient effort from airway pressure and flow sensors attached to the patient using an adaptive mathematical model. The patient effort is commonly measured via work of breathing, power of breathing, or pressure-time product of esophageal pressure and is important for properly adjusting ventilatory support for spontaneously breathing patients. The method of calculating this non-invasive predictor is based on linear or non-linear calculations using multiple parameters derived from the above-mentioned sensors.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: September 15, 2009
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Neil R. Euliano, Victor L. Brennan, Paul B. Blanch, Michael J. Banner
  • Publication number: 20090216145
    Abstract: A system which generates a warning signal in the event of looming pulmonary edema and/or looming decompensation. The system has an impedance detection unit for determining impedance values, which represent a transthoracic impedance course, and an impedance analysis unit (78), which is connected to the impedance detection unit. The impedance analysis unit (78) is implemented to determine the degree of modulation for a particular impedance course detected by the impedance detection unit.
    Type: Application
    Filed: February 20, 2009
    Publication date: August 27, 2009
    Inventors: Olaf SKERL, Micahel Lippert, Gerald Czygan, Stefan Paule
  • Patent number: 7540843
    Abstract: Methods of diagnosis and treatment of sleep apnea by taking measurements from a subject suffering from sleep apnea are disclosed. The methods include modelling the air flow through the upper airway of a subject suffering from sleep apnea.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: June 2, 2009
    Assignee: Universiteit Antwerpen
    Inventor: Wilfried De Backer
  • Patent number: 7491174
    Abstract: A system for performing electrical impedance tomography. The system includes a first set of electrodes positioned in a first plane and a second set of electrodes positioned in a second plane. The system also includes a third set of electrodes positioned in a third plane between the first and second planes. The third set of electrodes is rotatable around an axis intersecting the third plane. Furthermore, the third set of electrodes may be moveable in an axial direction between the first and second planes to various other planes, e.g., a fourth plane, a fifth plane, etc. The processor is further configured to process the voltage measurements taken by the voltage measurement device so as to generate a current density distribution in the various other planes. In addition, the processor is further configured to generate a three-dimensional image corresponding to the current density distribution between the first and second planes.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: February 17, 2009
    Assignee: Renal Research Institute, LLC
    Inventors: Fansan Zhu, Nathan W. Levin
  • Publication number: 20090012395
    Abstract: The present disclosure concerns embodiments of an acoustic plethysmograph for measuring pulmonary function of an animal, such as a mouse. The plethysmograph in exemplary embodiments can measure thoracic tidal volume of an unrestrained animal. The plethysmograph in exemplary embodiments acoustically excites the chamber containing the animal and detects changes in the acoustic pressure in the chamber, which correlate to the thoracic tidal volume of the animal. Unlike the conventional whole-body plethysmograph, this acoustic plethysmograph provides a direct measure of thoracic tidal volume. The plethysmograph also can be configured to measure chamber flow (the flow of air into and out of the chamber). Specific airway resistance of the animal can then be determined from the thoracic tidal volume and plethysmograph flow measurements.
    Type: Application
    Filed: July 7, 2008
    Publication date: January 8, 2009
    Inventors: Jeffrey S. Reynolds, David G. Frazer
  • Publication number: 20080281219
    Abstract: The present invention discloses a novel non-invasive, bedside system and method to monitor parameters associated lung changes. A novel approach for monitoring the operation of the respiratory system of a subject is provided. There is also provided a method for objectively evaluating the benefit of one mode of ventilation over another, and for assessing the differences in regional lung vibration during different modes of mechanical ventilation. The method comprises recording one or more signals from the subject, the signal varying in time according to operation of the respiratory system; and; processing the recorded signals to obtain a predetermined functional thereof presenting one or more time-varying energy functions of the subject, an abnormality in the one or more energy functions being indicative of a suspected abnormality in the operation of the respiratory system.
    Type: Application
    Filed: February 21, 2008
    Publication date: November 13, 2008
    Applicant: DeepBreeze Ltd.
    Inventors: Yael Glickman, Igal Kushnir, Smith Jean, Phillip Dellinger
  • Publication number: 20080269592
    Abstract: In a method for diagnosing functional lung illnesses, image exposures of the lungs are obtained at various phase points in time of the respiration of a subject, such as at maximum inhalation and maximum expiration, and the image exposures are segmented and at least two of the image exposures are compared on a segment-by-segment basis to identify a change in tissue density between the compared segments, as an indicator of lung functioning.
    Type: Application
    Filed: May 17, 2004
    Publication date: October 30, 2008
    Inventors: Rainer Kuth, Sabine Rupprecht, Thomas Rupprecht, Maren Zapke
  • Publication number: 20080257337
    Abstract: A method for delivering a medicament to a mechanically ventilated patient receiving a flow of breathing gas comprises delivering a respiratory maneuver to such a patient, monitoring the physiological effects of the respiratory maneuver on such patient, automatically establishing an optimized respiratory maneuver in response to the monitored physiological effects, and delivering the optimized respiratory maneuver to such a patient. A system for delivering an aerosolized medicament to a ventilated patient is also provided.
    Type: Application
    Filed: April 10, 2008
    Publication date: October 23, 2008
    Inventors: Jonathan S. H. Denyer, Ivan R. Prince
  • Patent number: 7427269
    Abstract: An apparatus and method to characterize NO gas exchange dynamics in human lungs comprising the steps of: (1) performing a series of breath hold maneuvers of progressively increasingly breath hold times, each breath hold maneuver comprising a) inhaling a gas, b) holding a breath for a selected time duration, and c) exhaling at a flow rate which is uncontrolled but which is effective to ensure evacuation of the airway space and (2) measuring airway NO parameters during consecutive breath hold maneuvers. As a result disease states of the lungs are diagnosed using the measured airway NO parameters.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: September 23, 2008
    Assignee: The Regents of the University of California
    Inventors: Steven C. George, Hye-Won Shin, Peter Condorelli
  • Patent number: 7425201
    Abstract: A method of creating a non-invasive predictor of both physiologic and imposed patient effort from airway pressure and flow sensors attached to the patient using an adaptive mathematical model. The patient effort is commonly measured via work of breathing, power of breathing, or pressure-time product of esophageal pressure and is important for properly adjusting ventilatory support for spontaneously breathing patients. The method of calculating this non-invasive predictor is based on linear or non-linear calculations using multiple parameters derived from the above-mentioned sensors.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: September 16, 2008
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Neil R. Euliano, Victor L. Brennan, Paul B. Blanch, Michael J. Banner
  • Publication number: 20080221470
    Abstract: Described herein are nasal respiratory devices including an attachment site for a sensors and sensor adapters for securing at least a portion of a sensor to a nasal respiratory device. Sensor adapters typically have a body frame having at least two regions: an attachment region for securing the sensor adapter to the nasal respiratory device; and a sensor connector region for securing a sensor across from an outlet of the nasal respiratory device.
    Type: Application
    Filed: March 7, 2008
    Publication date: September 11, 2008
    Inventors: Elliot Sather, Toru Mino, Arthur Ferdinand, Bryan Loomas, Ryan Kendall Pierce, Rajiv Doshi
  • Patent number: 7418859
    Abstract: A device for measuring a volume flow, especially a tidal volume flow sensor, with a flow channel (1) and with a sensor element (6) arranged within the flow channel (1), is shown and described. The task of providing such a device, in which the sensor signal, which is generated by sensor elements arranged in the flow channel, remains as free as possible from distortions during the transmission to an evaluating unit, is accomplished by providing an internal circuit (3), which is arranged within the flow channel (1) and includes the sensor element (6). An external circuit (7) is arranged outside the flow channel (1). The external circuit (7) is designed for contactless, inductive coupling with the internal circuit (3) for supplying same with energy and for reading.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: September 2, 2008
    Assignee: Dräger Medical AG & Co. KG
    Inventors: Volkmar Schulz, Henning Gerder
  • Patent number: 7402139
    Abstract: An apparatus for determining the impedance (Zaw) of a patient's respiratory tract, by measuring the alternating pressure (dp) in the region of the patient's mouth after producing an oscillating air pressure signal, includes a mouthpiece, an electroacoustic transducer having a mechanical oscillation system for generating the oscillating air pressure signal, a tube for connecting the electroacoustic transducer to the mouthpiece, a reference resistance for determining the reference impedance (Zref), and a computing device for calculating the impedance (Zaw) of the respiratory tract on the basis of the reference impedance (Zref) of the reference resistance, the entire impedance (Zges) and the entire phase angle (Phi). The change in the deflection of the mechanical oscillation system on the electroacoustic transducer, caused by the alternating pressure (dp) of the breathing of the patient, can be measured in a contactless manner using at least one measuring device.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: July 22, 2008
    Inventor: Peter Ganshorn
  • Patent number: 7387124
    Abstract: The present invention provides a snore detection device comprising a pressure sensor for detecting vibration generated by the human body with respiration, a sound sensor for detecting sound generated by the human body with respiration, and a judging circuit for judging the occurrence of snoring based on output signals of the two sensors. The judging circuit detects a peak occurrence time in variations generated by the output signal of the pressure sensor and a peak occurrence time in variations generated by the output signal of the sound sensor, to judge whether snoring occurs based on the peak occurrence times, respectively, of vibration and sound.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: June 17, 2008
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Satoshi Noda, Takeshi Minamiura, Hidetaka Sakai
  • Publication number: 20080139956
    Abstract: The present invention generally relates to an apparatus and method analyzing the respiratory characteristics of a human respiratory system from impulse oscillometry data, through the use of a linear network of electrical components. The present invention offers an improved alternative to the RIC respiratory circuit model, with an addition of a peripheral resistance to account for the resistance presented by the respiratory system's small airways and of a capacitor to account for extrathoracic compliance. After air pressure and air flow measurements are obtained from the subject by performing Impulse Oscillometry System testing, a graphical representation of a mechanical impedance characteristic may be derived. This allows for the estimation and adjustment of parameter values of the linear network whose components correlate to the resistances, compliances and inertances inherent in the respiratory system.
    Type: Application
    Filed: December 6, 2006
    Publication date: June 12, 2008
    Inventor: Billy Ming Diong
  • Patent number: 7347824
    Abstract: The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: March 25, 2008
    Assignee: Pulmosonix Pty Ltd.
    Inventors: Malcolm Howard Wilkinson, Clive Andrew Ramsden, Philip John Berger
  • Patent number: 7325545
    Abstract: The present invention refers to a system and a method for the automatic detection of the expiratory flow limitation of a subject. In an embodiment thereof the system for the automatic detection of expiratory flow limitation of a subject comprises determining the respiratory impedance of the subject comprising an imaginary component and, eventually, of a real part or, at least, by applying a forcing signal with one or more spectral components to the airway opening of a subject combined with measuring time courses of pressure and flow at the airway opening; determining at least one index linked to respiratory impedance or pressure and flow time courses; indicating the positioning of at least one index in relation to a preset threshold value.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: February 5, 2008
    Assignee: Politecnico di Milano
    Inventors: Raffaele Dellaca', Andrea Aliverti, Antonio Pedotti
  • Patent number: 7322937
    Abstract: In a method and breathing apparatus for assessing pulmonary stress, wherein pressure controlled flow of respiratory gas is generated, an ensuing flow is measured, resistance and compliance are determined based on measured pressure and flow and a stress index value is determined based on pressure, flow, resistance and compliance. The stress index value is 1 when no stress is present, ?1 when there is a risk for overdistension and ?1 when alveolar units are at a risk of being cyclically closed and opened. Implemented in a breathing apparatus the method can be used to assist an operator in diagnostic and therapeutic considerations in relation to a patient.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: January 29, 2008
    Assignee: Maquet Critical Care AB
    Inventors: Urban Blomberg, Ake Larsson, Kin-Chun Wong
  • Patent number: 7318808
    Abstract: A method for combining breathing rate measurements from two or more independent measurement channels. Independent measurements of breathing rate, for instance by impedance pneumography and photoplethysmography, can be combined to derive an improved measurement eliminating artefacts on one channel. A model of the process generating the breathing rate, is constructed and is run independently for each channel to generate predictions of the breathing rate. The model may be a Kalman filter. The measured values are compared with the predicted values and the difference is used as an indication of the confidence in the measurement, the higher the difference the lower the confidence. The measurements from the two channels are combined using weights calculated from the respected differences.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: January 15, 2008
    Assignee: Isis Innovation Limited
    Inventors: Lionel Tarassenko, Catherine Laura Mason
  • Patent number: 7282032
    Abstract: A portable, handheld device for measuring lung- and airway-specific respiratory parameters. The device defines a chamber in fluid communication with a mouthpiece. A sensor and/or a flow sensor monitor pressure and/or airflow within the device. A respiratory gas source, e.g., an internal pump, or an external compressor, is also in fluid communication with the chamber and a mouthpiece. The device operates in an active phase and a passive phase. In the active phase, a subject forcibly exhales into the device and the sensors collect spirometric data. In the passive phase, the pump is activated to pump air from the device and inflate the subject's lungs to a specific capacity. The sensors monitor pressure and/or flow as the air is introduced into the subject's respiratory system. The data collected by the sensor is used to determine lung and airway specific parameters, including but not limited to, airway conductance, airway resistance, airway compliance and total lung capacity.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: October 16, 2007
    Inventor: Thomas P. Miller
  • Publication number: 20070167855
    Abstract: A system, medium, and method conducing a user's breathing, in which a sound generated during a user's exhale and/or an ambient temperature change occurring during the exhale is sensed to measure a respiratory waveform of the user. Respiratory information of the user may then be produced from the respiratory waveform, and when the respiratory information of the user is different from normal respiratory information of the user, breathing information according to the normal respiratory information may be provided to the user so the user can use the same to modify their breathing.
    Type: Application
    Filed: November 22, 2006
    Publication date: July 19, 2007
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sang Hoon Shin, Sun Gi Hong, Kyung Ho Kim, Wan Taek Han
  • Patent number: 7241269
    Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.
    Type: Grant
    Filed: September 2, 2003
    Date of Patent: July 10, 2007
    Assignee: Respiratory Management Technology
    Inventors: Michael McCawley, Gary Ganser, Ian Christie, Tal Gottesman, James Dalton
  • Patent number: 7207947
    Abstract: Techniques are provided for detecting the circadian state of a patient using an implantable medical device based on selected blood carbon dioxide (CO2) parameters. In one example, the implantable device tracks changes in end tidal CO2 (etCO2) levels and changes in maximum variations of pCO2 levels per breathing cycle (?cycleCO2) over the course of the day and determines the circadian state based thereon. It has been found that average etCO2 levels are generally highest and average ?cycleCO2 levels are generally lowest while a patient is asleep and opposite while a patient is awake. Hence, by tracking changes in average etCO2 and ?cycleCO2 levels over the course of the day, circadian states can be detected. Minute ventilation and activity levels are used to assist in the determination of the circadian state. Additional techniques are directed to detecting the stage of sleep.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: April 24, 2007
    Assignee: Pacesetter, Inc.
    Inventors: Steve Koh, Euljoon Park
  • Patent number: 7189204
    Abstract: Devices and methods for sleep detection involve the use of an adjustable threshold for detecting sleep onset and termination. A method for detecting sleep includes adjusting a sleep threshold associated with a first sleep-related signal using a second sleep-related signal. The first sleep-related signal is compared to the adjusted threshold and sleep is detected based on the comparison. The sleep-related signals may be derived from implantable or external sensors. Additional sleep-related signals may be used to confirm the sleep condition. A sleep detector device implementing a sleep detection method may be a component of an implantable pulse generator such as a pacemaker or defibrillator.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: March 13, 2007
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Quan Ni, Zoe Hajenga, Douglas R. Daum, Jeff E. Stahmann, John D. Hatlestad, Kent Lee
  • Patent number: 7172557
    Abstract: A spirometer coupled to a manual resuscitator. An air tube in the spirometer has a converging section, a laminar flow section and a pressure recovery section. A microcontroller and a display of expiratory flow parameters is provided.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: February 6, 2007
    Assignee: Caldyne, Inc.
    Inventor: Frederick A. Parker
  • Patent number: 7169112
    Abstract: This invention relates to non-contact monitoring devices, and more particularly, non-contact respiration monitoring devices. According to the invention there is provided a monitoring device having a body defining an air monitoring channel between an air inlet and an air outlet. Disposed in monitoring channel is a respiration detection means, such as a flap-valve, which operates with associated logic circuitry to report the presence or absence of respiration via visual and audible displays. The device may be configured to attached, or be integrally connected to, the air input orifice of an air filter canister of a gas mask or the like. Alternatively, the device may be associated with the air output orifices or valves of a gas mask or the like.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: January 30, 2007
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Donald W. Caldwell
  • Patent number: 7128717
    Abstract: A method of determining whether an individual's breathing is obstructed. The method includes measuring a transthoracic impedance of the individual over a predetermined time interval, identifying a baseline impedance and selecting an impedance cycle. The method also includes identifying a maximum impedance during the selected impedance cycle, determining an upper difference between the maximum impedance and the baseline impedance, identifying a minimum impedance during the selected impedance cycle, and determining a lower difference between the minimum impedance and the baseline impedance. The method includes determining whether an amplitude of the upper difference is less than about seventy percent of an amplitude of the lower difference, and notifying an observer that the amplitude of the upper difference is less than about seventy percent of the amplitude of the lower difference.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: October 31, 2006
    Assignee: Washington University
    Inventors: Bradley T. Thach, Mary Pylipow
  • Patent number: 7122010
    Abstract: The invention refers to a method for the regional determination of the alveolar opening and alveolar closing of the lung depending on the respiration pressure, wherein according to the method of electrical impedance tomography, an impedance signal is measured in at least one lung zone depending on the respiration pressure. The alveolar opening or closing of a lung zone is determined, in particular to enable an improved artificial respiration.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: October 17, 2006
    Inventors: Stephan Böhm, Marcelo B. P. Amato, Peter W. A. Kunst
  • Patent number: 7072706
    Abstract: The present invention offers novel equilibration methods for very high resolution, three-dimensional imaging of imaging of lung compliance and distribution of functional residual capacity (FRC) in the lung using hyperpolarized helium-3 (3He) gas (H3He), and collecting local magnetic resonance image data therefrom. Using the present methods permits many functions that have been performed on a regional level for the whole lung using non-polarized helium, to be calculated for the first time from the local MRI measurements of local H3He, such as measuring volume or compliance.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: July 4, 2006
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James Baumgardner, David Lipson, Rahim Rizi, David Roberts, Mitchell Schnall
  • Patent number: 7063669
    Abstract: A spirometer having a housing with an elongated flow chamber open at one end, a pressure sensing end opposite the open end and an outlet passageway intercepting the flow chamber at an angle ? and proximate the pressure sensing end. A differential pressure sensor is coupled to the pressure sensing end from a port at an angle ? to an axis of the flow chamber. The angle ? is substantially greater than 0° but substantially less than 180° while the angle ? may range from 90° to 180°, such that a significantly increased measured air pressure results over that measured when ?=180° and ?=90°.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: June 20, 2006
    Assignee: Dynamic MT AG
    Inventors: David Brawner, Christopher Hegarty
  • Patent number: 6986745
    Abstract: A device having variable inspiratory resistance suitable for measuring the inspiratory strength of a patient which comprises a chamber in communication with a mouthpiece, said chamber (a) being provided with a calibration system for measuring the inhalation flow rate during inhalation through the mouthpiece and (b) being provided with a variable resistance feature by which the resistance to airflow through the device may be altered.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: January 17, 2006
    Assignee: Smithkline Beecham Corp.
    Inventors: Philip William Farr, Thomas Paul McCarthy
  • Patent number: 6890306
    Abstract: An active medical device have an improved diagnosis of a sleep apnea syndrome. This device measures the respiratory activity of the patient, determines a state of activity, this state being likely to take, according to satisfaction of predetermined criteria, a value representative of a state of sleep of the patient, and analyzes a detected signal corresponding to the respiratory activity to detect, when the aforementioned state is a state of sleep, the presence of respiratory pauses, and thereby to produce an indicating signal of sleep apnea in the event of the occurrence of a respiratory pause of duration longer than a first predetermined duration. The analysis also includes inhibiting the production of the aforesaid indicating signal, or a treatment to resolve an apnea, when the duration of the detected respiratory pause is longer than a second predetermined duration, typically of at least one minute.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: May 10, 2005
    Assignee: ELA Medical S.A.
    Inventor: Yann Poezevera
  • Patent number: 6793629
    Abstract: A diagnostic device having a nose fitting used without connection to a breathing gas supply for obtaining flow data values at ambient pressure. The nose fitting is connected to a pressure or flow sensor that supplies data values to a microprocessor. The detection and measurement of breathing gas flow is made from a tight sealing nose fitting (mask or prongs) configured with a resistive element inserted in the flow stream as breathing gas exits from and enters into the fitting. The nasal fitting is further provided with a port for connection to a flow or pressure transducer. The resistive element causes a pressure difference to occur between the upstream side and the downstream side when air flows through the element. The data values may be stored in computer memory to be analyzed for flow limitations.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: September 21, 2004
    Assignees: New York University, Puritan-Bennett Corporation
    Inventors: David M. Rapoport, Robert G. Norman, Roger A. Gruenke
  • Patent number: 4771899
    Abstract: An accessory rack for storing a plurality of articles such as wearing apparel or clothing accessories including jewelry, scarfs, ties, belts, chains, handbags, beads and the like and which includes a plurality of generally C-shaped hooks which are suspended from a telescoping housing so as to provide upper and lower rows of horizontally oriented and spaced support bars upon which such articles may be selectively and securely supported.
    Type: Grant
    Filed: January 22, 1988
    Date of Patent: September 20, 1988
    Assignee: Benedict Engineering Co., Inc.
    Inventors: Charles E. Benedict, Judith B. McGinnis