Abstract: A flow sensor includes a fluid chamber configured to receive a fluid. A diaphragm assembly is configured to be displaced whenever the fluid within the fluid chamber is displaced. A transducer assembly is configured to monitor the displacement of the diaphragm assembly and generate a signal based, at least in part, upon the quantity of fluid displaced within the fluid chamber.

Abstract: The present invention relates to a cap assembly 10 configured to be connectable to a suitable medicament delivery device having a distal and a proximal end. The cap assembly 10 according to the present invention comprises a removable outer 12 cap and a removable inner 16 cap movably connected in relation to each other. Further, said cap assembly is configured to allow said removable outer cap and said removable inner cap to be fixedly connectable to each other such that the removable outer cap is prevented of being movable with respect to the removable inner cap only when the medicament delivery device is held in a substantially vertical position such that both said removable outer cap and said removable inner cap can be removed from the cap assembly.

Abstract: An assembly for a drug delivery device is provided, the assembly having a compression spring, wherein the compression spring is compressed during the setting of a dose of a drug. The assembly further comprises a sleeve member, wherein the compression spring is in direct contact with the sleeve member and wherein the compression spring and the sleeve member are configured such that a relaxation of the compression spring effects a rotational and an axial movement of the sleeve member in a proximal direction, thereby causing a dispensing of a dose from the drug delivery device.

Abstract: A light guide body configured to guide light that enters therein has a light exit surface through which light from the at least one light source exits, and a plurality of linearly arranged pattern groups, each of which has a plurality of linearly arranged reflection patterns that reflect the light from the at least one light source toward the light exit surface. At least one of the plurality of linearly arranged pattern groups differs from at least another of the plurality of linearly arranged pattern groups in light amount difference. The light amount difference is a difference between an amount of light which reaches an observer of the light exit surface after being reflected by each of the plurality of linearly arranged pattern groups and an amount of light which reaches the observer through a region which is adjacent to each of the plurality of linearly arranged pattern groups.

Abstract: A modular medical pump system provides separate pump units that may be pre-associated with flexible tubes. Multiple pump units may be installed in a controller that coordinates operation of the pump units for delivery of multiple medicaments to a patient. The pump units may carry drug information and the controller may hold patient information allowing drug delivery and interaction to be assessed by the controller.

Abstract: An automatic regulating system for regulation of liquid pressure includes a container, a tubing connected between the human tissue and the container, a switch unit controllable to switch between first and second states, a pressure sensor for measuring liquid pressure in the human tissue, a level sensor for detecting a liquid level in the container, and a control module controlling switching of the switch unit according to the liquid pressure and the liquid level detection. Fluid communication between the human tissue and the container is prevented in the first state but is permitted in the second state. Fluid communication between the human tissue and the pressure sensor is permitted in the first state but is prevented in the second state.

Abstract: Some embodiments of a wearable, disposable medicine dispensing device may include a piston rod that is advanced to dispense medicine from the device. A rotational motor may be coupled to a drive mechanism so as to carry out a certain number of revolutions and thereby displace the piston rod by a desired distance. Such a device can be used in a method of dispensing liquid medicine.

Abstract: A fill adapter for filling a reservoir and a related method are disclosed herein. The fill adapter includes a button assembly actuator and a pump chamber plunger actuator hingeably attached to the button assembly actuator, wherein the actuation of the button assembly actuator actuates the pump chamber plunger actuator and wherein the pump chamber plunger actuator actuates a pump chamber membrane before the at least one button assembly is actuated.

Abstract: A sensor system of a medical system, in particular a manually operable, gravimetric system for continuous ambulant peritoneal dialysis (CAPD), provides for detection of a treatment status. In particular, the sensor system provides for detection of a phase segment and/or a phase transition during the peritoneal dialysis.

Abstract: Sensors for catheter pumps are disclosed herein. The catheter pump can include a catheter assembly comprising a catheter and a cannula coupled to a distal portion of the catheter. The cannula can have a proximal port for permitting the flow of blood therethrough. The catheter assembly can include a sensor to be disposed near the proximal port. A processing unit can be programmed to process a signal detected by the sensor. The processing unit can comprise a computer-readable set of rules to evaluate the signal to determine a position of the cannula relative to an aortic valve of a patient.

Abstract: A configuration management resource keeps track of incremental updates to a locally stored copy of configuration information (such as drug library information) used by a medical device to administer treatment to patients. The medical device retrieves a copy of the configuration information from a configuration management resource. Unbeknownst to a user of the medical device, to ensure that the medical device has most up-to-date configuration information, the medical device communicates a request for updates to the configuration management resource. To service the received request for updated configuration information, the configuration management resource forwards incrementally available configuration update information to the requesting medical device. The medical device uses the received configuration update information from the configuration management resource to update its local version of configuration information stored in the medical device.

Abstract: A wound fluid collection system includes a canister with a chamber fluidly connected to a wound dressing in a tissue site through an inlet and also fluidly connected to a reduced pressure source through an outlet. At least a portion of the canister is collapsible and yet can be maintained in an extended state when exposed to subatmospheric pressure. The canister is releasably attachable to a supporting member.

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Abstract: A system and method for a patch-like, self-contained substance infusion device (700) which can be attached to a skin surface via an adhesive contact surface. A push button (780) activation assembly can then be used to remove an interlock (730), allowing a disk or Belleville spring (735) assembly to apply an essentially even and constant pressure to the contents of a fluid reservoir assembly (710). This allows the release of one or more spring-loaded patient needles (760) into the skin surface, and establishes a fluid communication path between the patient needles (760) and the pressurized fluid reservoir contents thereby delivering an infusion into the skin. The push button (780) activation assembly further allows the release of one or more improved safety mechanisms (794) after use.

Abstract: Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values.

Abstract: An injection device with a feedback mechanism includes a housing for a medicament container having a stopper, a plunger rod for acting on the stopper, a button interactively connected to the plunger rod, an activation member having a flexible locking device releasably connected to the plunger rod, a drive force device, a locking member slideably between positions in which the locking member either completely or partially surrounds the flexible locking device, and a guide rod. Audible and tactile information that an injection has started is provided by the plunger rod's hitting the stopper.

Abstract: A system includes a parameter generation system to determine at least one parameter for an injection procedure (for example, a parameter of an injection protocol or an imaging system parameter), the parameter generator system includes a physiologically based pharmacokinetic model to model propagation of a contrast medium injected into a patient including at least one of a non-linear saturation term in a peripheral venous compartment, at least one configurable transport delay term through at least one compartment, or an adaptation to model volumetric flow rate of blood and an effect thereof on the propagation of contrast medium after injection of contrast medium ceases. The physiologically based pharmacokinetic model can, for example, be discretizable.

Abstract: Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting an impending administration of the medication level exceeding a predetermined threshold level, retrieving one or more signals associated with the monitored physiological condition, determining an accuracy indication of the retrieved one or more signals associated with the monitored physiological condition, and executing the administration of the medication level based on the accuracy indication are provided.

Abstract: Assemblies and methods for delivering an implant to a patient are disclosed. A delivery assembly can comprise an elongate tube, an outer magnetic member, and an inner magnetic member. The elongate tube extends from a proximal end portion to a distal end portion and defines a delivery lumen. The outer magnetic member can be movable along an outer surface of the tube; the inner magnetic member can be positioned within the delivery lumen and magnetically coupled to the outer magnetic member through a sidewall of the tube. The inner magnetic member can be movable through the delivery lumen when actuated by relative movement between the outer magnetic member and the tube. The delivery assembly can further comprise a syringe or an inflator/deflator couplable to a hub at the proximal end portion of the tube. The syringe or inflator/deflator can be used to urge fluid against a proximal end portion of the inner magnetic member.

Abstract: A method of performing a certification on an enteral feeding pump based on at least one operating parameter of the pump includes communicating certification information between the pump and a certification application remote from the pump. The at least one operating parameter is compared to a specified operating metric to verify that the at least one operating parameter of the pump is within the specified operating metric.

Abstract: An infusion set insertion device and method of use with an insertion device for an infusion set having an infusion set body including: a barrel defining a pull handle cavity; a pull handle slideably disposed in the pull handle cavity, the pull handle having an outer surface and defining an infusion set cavity and a release button cavity, the pull handle having a cocked position and an advanced position relative to the barrel; a release button slideably disposed in the release button cavity, the release button having a loaded position and a released position relative to the pull handle; and a driver operable to move the pull handle from the cocked position to the advanced position; wherein the release button extends a first axial distance beyond the outer surface when in the loaded position and extends a second axial distance into the infusion set cavity when in the released position.

Abstract: In one embodiment, system for real time monitoring of catheter aspiration includes a housing having a first port adapted for connection to a vacuum source and a second port adapted for connection with an aspiration catheter, a pressure sensor in fluid communication with an interior of the housing, a measurement device coupled to the pressure sensor and configured for measuring deviations in fluid pressure, and a communication device coupled to the measurement device and configured to generate an alert signal when a deviation in fluid pressure measured by the measurement device exceeds a pre-set threshold. In another embodiment, the system for real time monitoring of catheter aspiration further includes a vacuum source for connection to the first port and an aspiration catheter having an aspiration lumen for connection to the second port.

Abstract: The invention relates to a blood pump for the invasive application within a body of a patient comprising a rotor which is drivable about an axis of rotation and is radially compressible or expandable and which has a hub and at least one impeller blade fastened thereto, as well as comprising a housing which is compressible or expandable in the radial direction by an axial stretching or axial compression. The object of making both the rotor and the housing expandable and compressible in as simple a manner as possible is achieved in accordance with the invention in that a control body is provided which passes through the hub in the longitudinal direction, which is freely axially displaceable relative to the hub and which is coupled to the housing on the distal side of the rotor such that it exerts pulling and/or compression forces on the housing by a movement in the longitudinal direction with respect to the housing.

Abstract: A system for identifying information regarding a syringe assembly used with a fluid injector includes at least one syringe assembly having a barrel extending from a distal end to an open proximal end, at least one indicator provided on at least a portion of an outer circumferential surface of the barrel, an injector having at least one syringe port adapted to receive the at least one syringe assembly, and at least one sensor provided on or within at least a portion of each syringe port. The at least one indicator may conduct electricity corresponding to information regarding the at least one syringe assembly, which is identified by the at least one sensor.

Abstract: Apparatus are provided for medical devices and related operating systems and methods. An exemplary medical device includes a motor, one or more data storage elements to maintain control information, and a control module coupled to the motor and the one or more data storage elements. The control module is configured to obtain updated control information via a peer-to-peer communication session over a network, store the updated control information in the one or more data storage elements, and thereafter operate the motor based at least in part on the updated control information.

Abstract: A miniature portable multifunctional infusion device includes a liquid bottle (4) and a film box body (16) secured to a support frame (1). The film box body (16) is respectively provided with a directional input interface (17) and a directional output interface (14) in communication with the liquid bottle (4) and a needle via an infusion pipe. The film box body (16) is installed with an elastic film (27), and a transmission system (31) is arranged at a side of the elastic film (27). The transmission system (31) includes a miniature direct current motor (32) connected to a frequency modulating system (28). The miniature direct current motor (32) is connected to a spiral straightening device (34) via a speed reducer (33), and the spiral straightening device (34) is connected to a reciprocating film propping device (36) via a two-order shaft (43). A truncated cone (39) of the reciprocating film propping device (36) at a front end is in contact with the elastic film (27).

Abstract: The invention relates to an aspiration catheter for the extraction of thrombotic maternal from blood vessels. The catheter has a first and a second lumen, the first lumen being distally provided with an aspiration opening and the second lumen having a smaller cross section than the first lumen and extending coaxially in the distal region of the first lumen. The second lumen is provided with a lateral as well as a distally located opening, the lateral opening reaching through the wall of the catheter. Within the first lumen a stabilization wire is movably arranged which terminates distally of the lateral opening of the second lumen but proximally of the aspiration opening of the first lumen.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves obtaining a sequence of measurements indicative of a condition of the user that is influenced by the fluid and modifying one or more unusable measurements in the sequence using one or more other usable measurements in the sequence to obtain a modified sequence of measurements. The method continues by determining a predicted value for the condition of the user at a time in the future based at least in part on the modified sequence of measurements and operating the infusion device in a manner that is influenced by the predicted value.

Abstract: Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like.

Abstract: Components for a medical infusion fluid handling system, such as an APD system, in which one or more lines (such as solution lines), spikes or other connection ports may be automatically capped and/or de-capped. This feature may provide advantages, such as a reduced likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines, the spikes or the other connection ports. For example, a fluid handling cassette may include one or more caps that cover a corresponding spike and include a raised and/or recessed feature to assist in removal of the one or more caps from the cassette. A solution line cap may include a hole and a recess, a groove or other feature to engage with a spike cap and enable removal of the spike cap.

Abstract: A medication injection pen (50) includes a housing (1) and a dose set knob (2) rotatably connected to the housing (1) for setting a dose. An indicator member (200) is movable between a visible position indicating a zero position of the dose set knob (2) and a non-visible position indicating a non-zero position of the dose set knob (2). The indicator member is visible to a user in the visible position and not visible to the user in the non-visible position. The dose set knob is in the zero position when a set dose has been completely administered. Accordingly, a visible indication is provided to the user when a set dose has been completely administered.

Abstract: A fluid dispensing device is provided for dispensing a measured amount of fluid into a living organism. The device has a needle having a first end and a second end. The needle is adapted for interfacing, on the first end, with a septum of a flexible hollow membrane, and at a second end thereof, for subcutaneously inserting into a living organism. The needle is guided by a guide to permit an injection into the living organism at a substantially non-orthogonal angle with respect to a surface of the living organism. The first and second ends of the needle pierce their respective piercing surface while translating together in a common direction. In other embodiments, the dispensing device includes a main housing, a flexible fluid reservoir, an injection assembly and a trigger mechanism. The main housing houses the operative components of the device.

Abstract: A device for pumping blood, includes a housing having a distal end adapted to be coupled to a catheter, a proximal end having an outlet, and a tubular body extending between the distal and proximal ends along an axis. A rotor is rotatably disposed within the housing. A first magnetic bearing is operative to levitate the rotor along the axis within the housing. A second magnetic bearing controls a rotational frequency of the rotor. A third magnetic bearing controls a radial position of the rotor.

Abstract: A device for delivering fluid to a user includes a housing, a drive motor assembly in the housing, a force sensor, and an electronics module. The drive motor assembly regulates delivery of fluid by actuating a piston of a fluid reservoir, and the force sensor generates output levels in response to force imparted thereto during, for example, fluid delivery operations. The electronics module processes the output levels of the force sensor to assess the operating health of the force sensor, to check for occlusions in the fluid delivery path, and to monitor the seating status of the fluid reservoir.

Abstract: Apparatus and methods of dispensing fluid intravenously to a subject, and of flushing a line of an intravenous fluid administration apparatus, are provided. The apparatus may include a reservoir pump configured to operate in fluid communication with an upstream source of a first fluid and a downstream pressure-operated valve. The reservoir pump may also be configured to, during operation, automatically refill itself with the first fluid from the first upstream source. The downstream pressure-operated valve may be configured to operate in fluid communication with the reservoir pump and a second fluid source upstream of the pressure-operated valve, and to, during operation, dispense the first fluid to tubing downstream of the pressure-operated valve based on a pressure condition within the pressure-operated valve exceeding a threshold pressure.

Abstract: A liquid ejecting apparatus includes: an inflow channel to which liquid is supplied; an outflow channel communicated with a nozzle; a liquid chamber formed with a spiral flow channel having a substantially constant cross-sectional area between the inflow channel and the outflow channel and having a given volume; a volume changing portion configured to deform the liquid chamber so as to change the volume of the liquid chamber to a volume smaller than the given volume; and an ejection control unit configured to cause the liquid to be ejected from the nozzle in a pulsed manner by driving the volume changing portion in a state in which the liquid chamber is filled with the liquid.

Abstract: An infusion system for infusing a liquid into a body includes an external infusion device and a remote commander. The external infusion device includes a housing, a receiver, a processor and an indication device. The receiver is coupled to the housing and for receiving remotely generated commands. The processor is coupled to the housing and the receiver to receive remotely generated commands and to control the external infusion device in accordance with the commands. The indication device indicates when a command has been received and indicates when the command is being utilized to control the external infusion device so that the external infusion device is capable of being concealed from view when being remotely commanded. The remote commander includes a commander housing, a keypad for transmitting commands, and a transmitter for transmitting commands to the receiver of the external infusion device.

Abstract: A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the valve to open and close the first fluid pathway and to open and close the second fluid pathway.

Abstract: The invention relates to a stopper arrangement for a drug delivery device, comprising a stopper, a linear actor coupled with one end to the stopper and with an opposite end to a coupling arrangement, wherein the stopper arrangement is configured to be disposed within a container of a drug delivery device, wherein a shape and/or material of the stopper and the coupling arrangement are configured such that a first frictional force between the coupling arrangement and the container is lower than a frictional force between the stopper and the container when the linear actor is contracting and that second frictional force between the coupling arrangement and the container is greater than the frictional force between the stopper and the container when the linear actor is expanding.

Abstract: A device for the measurement of forces on the tip of a jet injector drug ampoule. Sensor consists of multiple spokes with strain sensing capability where each spoke has a modified linkage to allow for quasi-free bending behavior on one spoke end. By using the strain output of all three full bridges in parallel, it is possible to discriminate between lateral forces and axial forces directed collinear with the center axis of the ampoule applied to the tip of the nozzle. This information can be relayed to the user to attain, for example, a pre-determined contact force between the nozzle and an area receiving an injection.

Abstract: An apparatus for use in tube feeding has a cylindrical body provided with first opening and second openings connected by a flow channel. The body has a reagent, for determining a characteristic of fluid disposed in the body and a transparent window to view the reagent. In use, a first end of an internal feeding tube releasably engages with the first opening. The second, distal end of the feeding tube is disposed inside a patient. A second feeding tube engages with the second opening. The second feeding tube connects the apparatus to a bi-directional pump operable: to pump internal fluid from a reservoir, through the apparatus and into the internal feeding tube; and to pump fluid from the patient into the body of the apparatus. This allows a user to pump fluid from the patient into the body of the apparatus to react with the reagent.

Abstract: The present invention relates to a fluid delivery system that comprises a fluid container having a chamber structured to hold a fluid therein and a delivery device operable to control delivery of a fluid from the chamber of the fluid container. The fluid container includes a geometric mating member extending from an outer surface thereof. The delivery device includes a geometric mating receptacle structured to mate with at least a portion of the geometric mating member of the fluid container to verify compatibility of the fluid container with the delivery device. Alternatively or additionally, the fluid container may include a first data fixture component and the delivery device may include a second data fixture component that cooperates with the first data fixture component of the fluid container to verify compatibility of the fluid container with the delivery device.

Abstract: A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including: a main body having a bottom enclosure (104) that has a top surface including a button guide latch (268); a reservoir (160) disposed within the main body for containing the medicament; an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and communicating with the reservoir (160) when the device (100) is activated; a pressurizing system (140, 144) for pressurizing the reservoir (160) when the device (100) is activated; and an activator button (128) movably disposed on the main body and movable from a pre-activated position to an activated position. The activator button (128) includes an activation arm (228). When the activator button (128) moves from the pre-activated position to the activated position, an end of the activation arm (228) engages with the button guide latch (268) and prevents return movement of the activator button (128).

Abstract: The position of blood vessels can be more appropriately specified by means of appropriately selecting, on the basis of the conditions and components utilized, and angle between a light emitting unit optical axis of a near-infrared light emitting unit and a normal light of an irradiated surface, and angle between an optical axis of a light receiving side lens and the normal line of the irradiated surface, and an angle between a light receiving surface of a photo diode array and the light receiving unit optical axis. Thus, the subcutaneous blood vessel depth in the direction of the normal line from the irradiated surface can be specified based on changes in illumination intensity in a photodiode array. Consequently, the position of subcutaneous blood vessels can be easily specified.

Abstract: A syringe includes a barrel having a proximal end, a distal end, and a sidewall extending between the proximal end and the distal end along a longitudinal axis. At least one syringe retaining member protrudes radially outwardly relative to an outer surface of the sidewall. The at least one syringe retaining member tapers axially in a direction from the distal end toward the proximal end. The at least one syringe retaining member is configured for selective engagement with a locking mechanism on a fluid injector to releasably lock the syringe with the fluid injector. A taper of the at least one syringe retaining member is configured to rotationally guide the syringe into alignment with the locking mechanism.

Abstract: An insertion device for use with an insertion set is provided. The insertion device includes a first housing and a first member received in the first housing and movable relative to the first housing between a first position and a second position. The insertion device also includes a second housing substantially surrounding at least a portion of the first housing such that a gap exists between the first housing and the second housing. The first member is received in the gap in the second position. The second housing has at least one locking arm to couple the insertion set to the second housing. The first member is movable from the first position to the second position to uncouple the insertion set from the housing.

Abstract: A dosing device for an infusion system comprises a dosing unit having a variable volume and at least one opening in fluid connection with the variable volume, through which opening the variable volume can be filled with a substance or the substance can be dispensed from the variable volume. The dosing device is operable in a first state for filling the substance from a supply conduit, in a second state for preventing filling and dispensing, or in a third state for dispensing through a dispensing conduit. No direct fluid connection exists between the supply conduit and the dispensing conduit at any time. Methods for dosing a substance with the dosing device.

Abstract: A system to treat a patient comprises a user interface that allows a physician to view an image of tissue to be treated in order to develop a treatment plan to resect tissue with a predefined removal profile. The image may comprise a plurality of images, and the planned treatment is shown on the images. The treatment probe may comprise an anchor, and the image shown on the screen may have a reference image marker shown on the screen corresponding to the anchor. The planned tissue removal profile can be displayed and scaled to the image of the target tissue of an organ such as the prostate, and the physician can adjust the treatment profile based on the scaled images to provide a treatment profile in three dimensions. The images shown on the display may comprise segmented images of the patient with treatment plan overlaid on the images.

Abstract: A portable infusion pump can communicate with continuous glucose monitor (CGM) to receive continuous feedback relating to a user's blood glucose level during insulin or other medicament therapy and can automatically deliver insulin to a user when the CGM data indicates a need for additional insulin. Because patient behavior can interfere with the accuracy and efficacy of such closed loop or semi-closed loop therapy, a system can employ various mechanisms for manual temporary suspension of closed-loop therapy when a patient is aware that current or future behavior may inhibit therapy.

Abstract: An infusion pump system is disclosed. The system includes at least one infusion pump, a companion device, the companion device in wireless communication with the infusion pump, and a user interface on the companion device, the user interface adapted to receive textual input.