Including Means For Controlling Piston Stroke Length Patents (Class 604/208)
  • Publication number: 20130211374
    Abstract: An injection control device (ICD) for a syringe, injects/extracts material into/from at a rate controllably proportional to the rate of movement of the syringe. The device has body with a first and opposite second side, syringe holder, first aperture in the first side to accommodate a cannula of the accommodated syringe, second aperture in the first side, and third aperture in the second side. A positionable transmission reference member may be linearly extendable from the second aperture; a spooling rotating member with an axle is coupled to the body; a clutch is coupled to the rotating member; and a transmission system is interior to and coupled to the body which translates body motion, in relation to a fixed state of the reference member, to move the plunger of the syringe, causing injected/extracted of material into/from a subject as the syringe's cannula is traveling with the moving body.
    Type: Application
    Filed: January 5, 2013
    Publication date: August 15, 2013
    Inventor: Hugh Hetherington
  • Publication number: 20130211341
    Abstract: A dose setting mechanism for a drug delivery device. The mechanism may comprise a drug delivery device housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A split threaded insert is in threaded engagement with the dose dial component. The insert can transform from a first configuration to a second configuration when the dose dial component is rotated. In one dose setting mechanism arrangement, the first configuration may comprise a first open configuration and the second configuration may comprise a second closed configuration.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 15, 2013
    Applicant: Sanofi-Aventis Deutschland GmbH
    Inventors: Simon Lewis Bilton, David Martin Leak
  • Publication number: 20130204203
    Abstract: The present invention relates to a drug delivery device for dispensing of a dose of a medicinal product, comprising: a first housing component (12, 52; 62) adapted to receive a cartridge (16) comprising the medicinal product and further comprising a piston (18) slidably arranged therein in an axial direction, a second housing component (14; 54; 64) adapted to receive a dose dispensing mechanism having a piston rod (20) to be operably engaged with the cartridge's piston (18), wherein the first and the second housing components (12, 14; 52, 54; 62, 64) are displaceably arranged in axial direction relative to each other for reducing an axial distance (34) between the piston (18) and the piston rod (20) to a pre-defined degree, and an interlock means (30) adapted to interact with at least one of first and second housing components (12, 14; 52, 54; 62, 64) for mutually locking into position first and second housing components (12, 14; 52, 54; 62, 64).
    Type: Application
    Filed: March 16, 2011
    Publication date: August 8, 2013
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Lutz Mueller, Claudia Matthias, Michael Helmer, Steffen Raab, Axel Forstreutter
  • Patent number: 8500693
    Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: August 6, 2013
    Assignee: Becton Dickinson France
    Inventor: Lionel Maritan
  • Patent number: 8500700
    Abstract: A dosing unit for an ambulatory infusion device and a method of operation are disclosed. The dosing unit includes a stationary member, a movable member, and a plunger. The movable member and the stationary member, together, make a charging valve and a discharging valve. The plunger is located, at least in part, in a metering cavity of the movable member and the movable member is adapted to selectively couple and decouple a driving unit, such that, by operating the driving unit with the movable member being coupled with the driving unit, the movable member moves with the plunger to maintain a position of the plunger relative to the movable member along a displacement axis, and by operating the driving unit with the movable member being decoupled from the driving unit, the plunger is displaced while the position of the movable member is maintained.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: August 6, 2013
    Assignee: Roche Diagnostics International AG
    Inventors: Ulrich Haueter, Martin Wyss, Florian Kuehni
  • Patent number: 8500701
    Abstract: A device for administering a product dose, the device including a display drum for displaying the product dose, a housing, a first conveying member moveable relative to the housing in a conveying direction, a second conveying member moveable relative to the housing in and counter to the conveying direction, the second conveying member in a first threaded engagement with the first conveying member while being rotationally movable relative to the housing and the first conveying member and being translationally movable relative to the first conveying member counter to the conveying direction, a metering apparatus by which the product dose can be adjusted and which encompasses the display drum, the display drum being rotationally movable relative to the housing while being translationally movable in and counter to the conveying direction in a second threaded engagement, and a coupling element which interconnects the first conveying member and the display drum in a torsion-resistant manner in a coupling engagement
    Type: Grant
    Filed: August 22, 2007
    Date of Patent: August 6, 2013
    Assignee: TecPharma Licensing AG
    Inventor: Fritz Kirchhofer
  • Patent number: 8491538
    Abstract: An injection device including a drive unit, a delivery unit, a dosing unit, a trigger for triggering an injection, a first coupling mechanism between the drive unit and the delivery unit, and a second coupling mechanism between the dosing unit and the drive unit, wherein the drive unit is tensioned by a rotation of the dosing unit and when the drive unit is tensioned the first coupling mechanism is disengaged and the second coupling mechanism is engaged, and wherein when an injection is triggered first the first coupling mechanism is engaged and then the second coupling mechanism is disengaged. In some embodiments, the device may include a third coupling mechanism which only releases the delivery unit after the engagement and disengagement which follow a triggering.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: July 23, 2013
    Assignee: TecPharma Licensing AG
    Inventors: Philippe Kohlbrenner, Peter Stettler, Patrick Hostettler, Juergen Wittmann, Martin Wittwer
  • Patent number: 8491536
    Abstract: A dose setting mechanism for a medicament delivery device is presented having a pinion mounted to a locking member where the axis of rotation of the pinion is offset and parallel to the longitudinal axis of the housing containing the dose setting components. Primary and secondary dose members are engaged with the pinion to indicate a set dose of medicament.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: July 23, 2013
    Assignee: SHL Group AB
    Inventors: Lucio Giambattista, Antonio Bendek
  • Publication number: 20130184651
    Abstract: An assembly is disclosed comprising: a reservoir holder, a dose setting mechanism, and flexible fastener configured to fasten the reservoir holder to the dose setting mechanism, wherein the flexible fastener is provided at one of the reservoir holder and the dose setting mechanism. The flexible fastener is configured to releasably fasten the reservoir holder and the dose setting mechanism to each other. Moreover, said flexible fastener is arranged on a retention ring provided at the one of the reservoir holder and the dose setting mechanism. Furthermore, a drug delivery device with such an assembly is disclosed.
    Type: Application
    Filed: September 28, 2011
    Publication date: July 18, 2013
    Applicant: Sanofi-Aventis Deutschland GmbH
    Inventors: Richard James Vincent Avery, Aled Meredydd James
  • Publication number: 20130184677
    Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.
    Type: Application
    Filed: January 17, 2013
    Publication date: July 18, 2013
    Inventor: Daniel Py
  • Patent number: 8480633
    Abstract: A pump drive and a method thereof to dispense a liquid drug from a container having a plunger piston are disclosed. The pump drive provides a unidirectional clutch provided about a rotational axis which supports centrally a wheel. The clutch has an inner race operably connected to the plunger piston, wherein the clutch is configured to rotate both the inner race about the axis in unison with rotation of the wheel in only a first direction to advance the plunger piston, and to let the wheel rotate relative to the inner race about the axis in a second direction opposite to the first direction without advancing the piston plunger. The drive in one embodiment includes at least one shape memory alloy wire which when excited rotates the wheel in the first rotational direction to advance the piston plunger and dispense the liquid drug from the container.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: July 9, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Steven N. Roe
  • Patent number: 8475413
    Abstract: A drive device for advancing an advancing element (2; 33) relative to a housing (1; 30) over a entire advancing distance (G) comprises a tensioning device having a tensioning element (3; 39) for tensioning a spring device (4). A predetermined distance (A) between the tensioning element (39) and the advancing element (33) or between the counter element (7) and the tensioning element (3) that engages with advancing element can be set according to the advancing of the advancing element (2; 33) by a partial advancing distance that is less than the entire advancing distance (G). According to a method for discharging a fluid product from a container (16) via an outlet (17), a plunger (18) is displaced inside the container (16) by means of a drive device provided with an advancing element (2; 33) and with a spring device (4), whereby the spring device (4) is tensioned by a tensioning device according to the advancing of the advancing element (2; 33) by a partial advancing distance.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: July 2, 2013
    Assignee: Roche Diagnostics International AG
    Inventors: Hanspeter Heiniger, Stefan Jost, Roger Siegenthaler, Heinz Wu thrich
  • Patent number: 8469930
    Abstract: A dosing unit for an ambulatory infusion device and a method of operation are disclosed. The dosing unit includes a stationary member, a movable member, and a plunger. The movable member and the stationary member, together, make a charging valve and a discharging valve. The plunger is located, at least in part, in a metering cavity of the movable member and the movable member is adapted to selectively couple and decouple a driving unit, such that, by operating the driving unit with the movable member being coupled with the driving unit, the movable member moves with the plunger to maintain a position of the plunger relative to the movable member along a displacement axis, and by operating the driving unit with the movable member being decoupled from the driving unit, the plunger is displaced while the position of the movable member is maintained.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: June 25, 2013
    Assignee: Roche Diagnostics International AG
    Inventors: Ulrich Haueter, Martin Wyss, Florian Kuehni
  • Patent number: 8444606
    Abstract: The invention concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a housing having an interior thread formed as an outwardly pointing thread carried on an upstanding tower centrally located in the pen shaped device. This outwardly pointing thread forms a first thread connection with the interior thread of the rotatable scale drum. The injection device further comprises a driver for moving the piston rod forward when moved axially. The driver operates the piston rod through a second thread connection having a pitch different than the first thread connection.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: May 21, 2013
    Assignee: Novo Nordisk A/S
    Inventors: Bo Radmer, Claus Schmidt Moller, Lars Morch Groth, Klaus Thogersen
  • Publication number: 20130102969
    Abstract: The present disclosure is directed to a dose setting mechanism that may be used with a drug delivery device. The dose setting mechanism may include an inner body having a helical thread along an outer cylindrical surface of the inner body, and a drive sleeve for driving a piston rod in an axial direction, the drive sleeve positioned within at least a portion of the inner body. The dose setting mechanism may further include a dose dial sleeve rotatably engaged with the helical thread of the inner body and a dial grip connected to the dose dial sleeve and releasably connected to the drive sleeve. Further when a dose is set, the dial grip is rotated so that both the dose dial sleeve and the drive sleeve rotate with respect to the inner body.
    Type: Application
    Filed: November 2, 2012
    Publication date: April 25, 2013
    Applicant: DCA DESIGN INTERNATIONAL LTD
    Inventor: DCA Design International Ltd
  • Publication number: 20130090603
    Abstract: A dosage control syringe includes a barrel, a plunger, an adjustable lock member supported along a guide (such as a track) that is disposed along or outside an outer wall of the syringe barrel, and a stop member coupled to the plunger or the lock member. The stop member is generally aligned between the adjustable lock member and a portion of the plunger so as to limit or preclude further movement of the plunger upon engagement of the stop member with both the lock member and the plunger. The plunger is stopped by the lock member, via the stop member, when the plunger has traveled a predetermined distance set by the lock member, the distance corresponding to a desired dosage of fluid from the syringe.
    Type: Application
    Filed: June 28, 2011
    Publication date: April 11, 2013
    Inventor: John D. Hoyle, JR.
  • Patent number: 8409150
    Abstract: Ampoules for dispensing flowable substances and metering systems incorporating the same are described herein. An ampoule for a flowable substance includes an ampoule body comprising an interior space for receiving the flowable substance and an inner circumferential surface having a guide region and a sealing region. A piston may be disposed in the interior space of the ampoule body such that the piston is slidably displaceable along a direction of displacement. The piston includes at least one sealing element for forming a seal with the inner circumferential surface in a contact zone on the outer circumference of the sealing element. The sealing element has a first compression state when the contact zone is in the guide region and a second compression state when the contact zone is in the sealing region. A second blocking device prevents movement of the contact zone from the sealing region to the guide region.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: April 2, 2013
    Assignee: Roche Diagnostics International AG
    Inventors: Ruedi Zihlmann, Ronny-Patric Horisberger, Daniel Fehlmann
  • Patent number: 8409148
    Abstract: A device for the dosed administration of a fluid product including a housing, a conveying device for the product, a drive element influenced by the selection of a product dose, a coupling input member coupled to the drive element, a coupling output member coupled to the conveying device, a retaining device which maintains the coupling elements in a maintaining position uncoupled from each other, wherein at least one of the coupling elements is displaceable by a coupling movement from the maintaining position into a coupling state, and wherein a driving force of the drive element causes a delivery movement of the conveying device via the coupling elements.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: April 2, 2013
    Assignee: TecPharma Licensing AG
    Inventors: Patrick Fiechter, Philippe Kohlbrenner, Daniel Kuenzli, Christof Meier, Peter Stettler, Juergen Wittmann, Urs Widmer
  • Publication number: 20130046249
    Abstract: An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.
    Type: Application
    Filed: October 15, 2010
    Publication date: February 21, 2013
    Applicant: OWEN MUMFORD LIMITED
    Inventor: Toby Cowe
  • Patent number: 8376997
    Abstract: The present invention relates to a device for expelling a predetermined quantity of medicament comprising driving means comprising an energy-accumulating member, a nut, and a driver for driving a pressure means; and activation means for activating said driving means wherein said pressure means comprises a movable wall part arranged inside a 2 container and a threaded plunger rod arranged to interact with said driving means for pushing said movable wall part forwardly, and wherein said activation means comprises a manually operated push button arranged on the front end of the device for promoting an ergonomic handling of the device and wherein said activation means are capable of interacting with said driving means in a stepwise mode; such that each time said push button is depressed said pressure means moves an step exerting pressure on the medicament inside the container and expelling a predetermined quantity of the medicament through the opening.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: February 19, 2013
    Assignee: SHL Group AB
    Inventors: Stefan Hogdahl, Anders Karlsson
  • Publication number: 20130041344
    Abstract: A medication delivery device (100) comprises a container (101) for holding a medication (104) and a piston (102) which is at least partly arranged within the container (101) and which is axially displaceable with respect to the container (101). The piston (102) is at least partly arranged at a distance from an inner surface (112) of the container (101), thereby providing a channel (116) between the piston (102) and the container (101). The device (100) further comprises a seal (103), the seal (103) being arranged to limit the channel (116) proximally.
    Type: Application
    Filed: September 15, 2010
    Publication date: February 14, 2013
    Applicant: SANOFI-AVENTIS DETUSCHLAND GMBH
    Inventor: Michael Heald
  • Publication number: 20130041325
    Abstract: A drug delivery device comprises a housing and a piston rod arranged in the housing. The piston rod is adapted to be moved along an axial direction to dispense a fluid. A drive member arranged in the housing is operatively coupled to the piston rod and adapted to set up a dose of fluid for dispense in response to a first movement. The drive member is also adapted to move the piston rod to dispense the dose in response to a second movement. The drug delivery device also comprises a pre-dispensing drive member operatively coupled to the drive member and the housing and adapted to move at least the drive member by a pre-dispensing distance between its first and second movement.
    Type: Application
    Filed: December 2, 2010
    Publication date: February 14, 2013
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Helmer, Steffen Raab
  • Patent number: 8366680
    Abstract: A resettable drive mechanism comprising a housing, a drive member rotatable in a second direction for delivering a dose of a medication, a piston rod driven by the drive member when it rotates in the second direction. A stop member prevents rotation of the drive member in a first direction opposite to the second direction, when the stop member engages the drive member. A clutch member is movable between a delivery position and a reset position. When the clutch member is in the delivery position, the stop member and the drive member are engaged and the drive member is prevented from rotating in the first direction, and when the clutch member is in the reset position, the drive member and the stop member are disengaged, the drive member is rotatable in the first direction and the piston rod is movable in the proximal direction.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: February 5, 2013
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Steffen Raab
  • Publication number: 20130030409
    Abstract: The instant application is directed to an assembly for a drug delivery device which is arranged to operate in two distinct modes, a priming mode starting from a pre-priming state and a dispense mode operating in a post-priming state, and a drug delivery device comprising this assembly. The assembly comprises a dose member, an actuating member and a piston rod which is configured to act on a bung of an assembled cartridge containing the drug. In the pre-priming state the actuating member is configured to be moved by a user such that the movement of the actuating member causes a movement of the dose member and such that the movement of the dose member causes a movement of the piston rod. In the post-priming state the dose member is configured to be moved by a user without causing a movement of the actuating member in order to perform a set and dispense action of the drug delivery device.
    Type: Application
    Filed: September 29, 2010
    Publication date: January 31, 2013
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Catherine Anne Macdonald, Robert Veasey, Garen Kouyoumjian, Christopher Jones, Alexander Ian Bailey
  • Publication number: 20130023830
    Abstract: The present invention relates to drug delivery device for dispensing of a predefined amount of a medicinal product, comprising: at least one housing component (2), a cartridge holder component (4) to receive a product-containing cartridge (3), the cartridge having a piston slidably arranged therein, a drive mechanism component operably engageable with the piston of the cartridge (3) for dispensing of a dose of the medicinal product, wherein at least one of said components (2, 4, 6) at least partially comprises a biodegradable plastic material comprising at least one additive adapted to modify a degradation process of the plastic material.
    Type: Application
    Filed: October 8, 2010
    Publication date: January 24, 2013
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Andreas Bode
  • Publication number: 20130023832
    Abstract: A drug delivery device for dispensing of a dose of a medicinal product, comprising a holder (14) for a product-containing cartridge (16), the cartridge (16) having a piston (18) slidably arranged therein in an axial direction, a piston rod (12) to be operably engaged with the cartridge's piston (18) for dispensing of a dose of the medicinal product, and at least one spacer (20) being selected according to a relative distance between piston (18) and piston rod (12) and being disposed between the piston rod (12) and the piston (18) for eliminating axial clearance between piston (18) and piston rod (12).
    Type: Application
    Filed: October 28, 2010
    Publication date: January 24, 2013
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: John Hiles
  • Publication number: 20130023831
    Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicinal product, comprising: a holder for a product-containing cartridge, the cartridge having a piston slidably arranged therein in an axial direction, a piston rod to be operably engaged with the cartridge's piston for dispensing of a dose of the medicinal product, an adjusting assembly adapted to eliminate axial clearance between the piston and the piston rod, wherein the adjusting assembly comprises at least one radially extending spike element for mutually locking in position the piston and the piston rod irrespective of the relative distance between piston and piston rod.
    Type: Application
    Filed: October 8, 2010
    Publication date: January 24, 2013
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Helmer, Claudia Matthias, Peter Nober, Reza Shahbazfar, Benjamin Schaefer, Leo Zeimetz
  • Publication number: 20120330244
    Abstract: The present invention relates to a drug delivery device for dispensing of a predefined dose of a medicinal product, comprising: a housing, a cartridge holder adapted to receive a cartridge containing the medicinal product to be dispensed, the cartridge holder being connectable to the housing, a drive mechanism to be operably engaged with the cartridge for setting and/or dispensing of a predefined dose of the medicinal product, wherein the drive mechanism is axially slidingly supported in the housing for compensating axial clearance between the drive mechanism and the cartridge and wherein the drive mechanism is axially fixable relative to the housing.
    Type: Application
    Filed: October 8, 2010
    Publication date: December 27, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Helmer, Claudia Matthias, Leo Zeimetz, Reza Shahbazfar, Benjamin Schaefer, Carsten Mosebach
  • Publication number: 20120310168
    Abstract: A drug delivery device (4) for dispensing one or more doses of a drug is provided. The device (4) comprises a drive member (1) for driving a piston rod (5) and a dose member (46) for actuating the drive member (1). The piston rod (5) is coupled to the drive member (1) such that a relative translational movement of the drive member (1) and the piston rod (5) is allowed and a relative rotational movement is prevented. The drive member (1) is configured to be driven by the dose member (46) around the longitudinal axis in a first (110) and a second rotational direction (111) opposite to each other. Furthermore, a drug delivery device (4) is provided, wherein the drive member (1) has stable and unstable states and wherein in an unstable state the drive member (1) is biased by biasing means (3) towards a stable state.
    Type: Application
    Filed: September 29, 2010
    Publication date: December 6, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: David Plumptre, Andrew Mark Lindsay, Catherine Anne MacDonald, Robert Veasey, Garen Kouyoumjian, Christopher Jones
  • Publication number: 20120302964
    Abstract: An assembly of a drug delivery device with a longitudinal axis (L) is given, comprising a body (1) with a proximal end (2) and a distal end (3). The drug delivery device further comprises a drive assembly and a first button member (4). The drive assembly is at least partially arranged within the body (1) and is adapted to facilitate dispense of a medicinal product. The first button member (4) acts on the drive assembly to prepare the drug delivery device for dispensing the medicinal product. The first button member (4) is adapted to be detachable from the body (1) after the preparation of the drug delivery device is completed.
    Type: Application
    Filed: September 29, 2010
    Publication date: November 29, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Catherine Anne MacDonald, Robert Veasey, Garen Kouyoumjian, Christopher Jones, Andrew Mark Lindsay, Michael Bainton
  • Publication number: 20120296286
    Abstract: A piston rod is arranged in a body and provided with a helical element and an axial element. A guide element, which is arranged in the body and fixed relatively to the body, is coupled to the helical element to guide a helical movement of the piston rod and coupled to the axial element to guide an axial movement of the piston rod. The axial movement allows a priming of the device preceding the helical movement of the piston rod.
    Type: Application
    Filed: September 3, 2010
    Publication date: November 22, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Steffen Raab, Sandra Arnhold
  • Publication number: 20120296285
    Abstract: An assembly of a drug delivery device comprises a body (10) having a distal end (11) and a proximal end (12), a drive assembly (4) arranged substantially within the body (10) to facilitate dispense of a medicinal product and a button member (5) arranged at the proximal end (12) of the body (10) and adapted to act upon the drive assembly (4). The drive assembly (4) has an initial pre-ready state, a transient state and a ready state; in the pre-ready and transient states the button member (5) is twistable with respect to the body (10) to act upon the drive assembly (4) and wherein in the ready state the button member (5) is axially moveable but not substantially twistable with respect to the body (10) to act upon the drive assembly (4) to dispense a dose of the medicinal product.
    Type: Application
    Filed: September 29, 2010
    Publication date: November 22, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Catherine Anne MacDonald, Robert Veasey, Garen Kouyoumjian, Christopher Jones, Andrew Mark Lindsay, Michael Bainton
  • Publication number: 20120289908
    Abstract: A resettable drive assembly for a drug delivery device (1) is provided. The drive assembly comprises a drive unit (3) for driving a piston rod (5) in a dispense operation of the device (1). The drive unit (3) comprises a first drive member (35), a second drive member (37) and locking means preventing a relative rotational movement of the first (35) and the second drive member (37) during a dispense operation and allowing a relative rotational movement for enabling a resetting of the device (1). Moreover, a drug delivery device (1) comprising a resettable drive assembly is provided.
    Type: Application
    Filed: September 29, 2010
    Publication date: November 15, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Garen Kouyoumjian, Robert Veasey, David Plumptre, Christopher Jones, Catherine Anne MacDonald, James May
  • Publication number: 20120283653
    Abstract: A resettable drive mechanism for a drug delivery device (1) comprises a piston rod assembly (32) and an interaction member (23). The piston rod assembly (32) comprises a guide track (18) running along the piston rod assembly (32), the guide track (18) comprising at least one delivery section (18A) and at least one reset section (18B). The reset section (18B) is arranged to continue the delivery section (18A). The delivery section (18A) comprises at least one blocking means (19). The interaction member (23) is configured to cooperate with the guide track (18). For delivering a dose of a drug (24), the piston rod assembly (32) is axially displaceable in a dose delivery direction away from an axial starting position, the interaction member (23) cooperating with the delivery section (18A) and the blocking means (19) passing the interaction member (23) when the piston rod assembly (32) is displaced in the dose delivery direction.
    Type: Application
    Filed: September 29, 2010
    Publication date: November 8, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Catherine Anne MacDonald, Robert Veasey, Christopher Jones, Garen Kouyoumjian
  • Publication number: 20120283649
    Abstract: A plunger and a lever are arranged in a body and provided with engaging elements engaging the lever with the plunger. The lever is disengageable from the plunger by a shift of the lever, thus enabling a movement of the plunger relatively to the body in the proximal direction.
    Type: Application
    Filed: September 29, 2010
    Publication date: November 8, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Robert Veasey, Simon Lewis Bilton, Christopher Jones, Garen Kouyoumjian, Catherine Anne Macdonald
  • Publication number: 20120283657
    Abstract: The present invention relates to an assembly forming a piston rod for advancing a cartridge bung in a drug delivery device, the assembly comprising a first member and a second member wherein in a first state, the first and the second member are moveable with respect to each other to adjust the length of the piston rod and wherein in a second state the first member is locked in position with respect to the second member in order to define a fixed length of the piston rod. Furthermore, it relates to a drug delivery device comprising the assembly and to a method for assembling such a drug delivery device.
    Type: Application
    Filed: September 29, 2010
    Publication date: November 8, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Garen Kouyoumjian, Robert Veasey, David Plumptre, Christopher Jones, Catherine Anne Macdonald, Matthew Jones
  • Publication number: 20120283650
    Abstract: The present invention relates to an assembly for a drug delivery device comprising a proximal end, a distal end and a moveable member, a dose member, a fixed member and coupling means, wherein in a first state, the moveable member is moveable in an axial direction with respect to the fixed member and the dose member and the coupling means retains the dose member to the fixed member, and wherein in a second state of the assembly, the moveable member is permanently connected with the dose member by means of the coupling means and the dose member is released from the fixed member and the assembly is configured to set and dispense a dose of a fluid medicinal product out of an assembled cartridge by movement of the dose member. Furthermore it relates to a method for setting-up a drug delivery device.
    Type: Application
    Filed: September 29, 2010
    Publication date: November 8, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Catherine Anne Macdonald, Robert Veasey, Garen Kouyoumjian, Christopher Jones, Andrew Mark Lindsay
  • Publication number: 20120253293
    Abstract: The present invention related to an injector is provided. The injector includes a case body, a dose setting, a first engagement, a second engagement, an elasticity element, and a button. The dose setting is used to preset a dose. The first engagement is connected with the dose setting. The elasticity element is connected between the first engagement and the second engagement. When the elasticity element is in an extension state, the first engagement and the second engagement are separated. When the button is pushed, the elasticity element is entered into a compress state to combine the first engagement and the second engagement, and then push the dose setting.
    Type: Application
    Filed: March 26, 2012
    Publication date: October 4, 2012
    Inventors: Yi-Hsin Huang, Chih-Chiang Yang, Chao-Wang Chen
  • Publication number: 20120245530
    Abstract: The present disclosure relates to devices for use in conjunction with a syringe in measuring a dose using the syringe. In certain embodiments, a clip is provided that includes an elongated portion for insertion into a barrel of a syringe and a locking portion that locks onto a feature of the syringe. Once inserted, the clip physically prevents retraction of a plunger of the syringe past a certain point corresponding to a desired dose.
    Type: Application
    Filed: March 21, 2011
    Publication date: September 27, 2012
    Applicant: William Marsh Rice University
    Inventors: Maria Oden, Julia Ellen Davidson Lukomnik, Cindy M. Dinh, Amanda Michelle Gutierrez, Carlos Amaro, Rebecca R. Richards-Kortum
  • Patent number: 8267900
    Abstract: The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: September 18, 2012
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Harms, Steffen Raab, Dominic George Webber, James Robert Howarth, Trevor John Beckett, Geoffrey Philip Gray, John David Cross
  • Patent number: 8257318
    Abstract: The application disclosed concerns an injection device for apportioning set doses of a drug from a reservoir (40) to a subject. The injection device comprises a rotatable scale drum (50) which is screwed out from the proximal end of the injection device when a does is set. The rotatable scale drum (50) is coupled to a piston rod drive (100, 130) through a push button (30) and a connector pipe (80). When setting a does, the push button (30) engages the scale drum (50) such that both the push button (30) and the scale drum (50) rotate away from the housing (10). During injection, the scale drum (50) is released from the push button (30) and engaged with the connector pipe (80) in order to rotate the piston rod (120).
    Type: Grant
    Filed: February 9, 2006
    Date of Patent: September 4, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Klaus Thogersen, Thomas Dedenroth Miller, Martin von Bulov, Peter Lundholm Jensen
  • Publication number: 20120220952
    Abstract: Ampoules for dispensing flowable substances and metering systems incorporating the same are described herein. An ampoule for a flowable substance includes an ampoule body comprising an interior space for receiving the flowable substance and an inner circumferential surface having a guide region and a sealing region. A piston may be disposed in the interior space of the ampoule body such that the piston is slidably displaceable along a direction of displacement. The piston includes a one sealing element for forming a seal with the inner circumferential surface in a contact zone on the outer circumference of the sealing element. The sealing element has as first compression state when the contact zone is in the guide region and a second compression state when the contact zone is in the sealing region. A second blocking device prevents movement of the contact zone from the sealing region to the guide region.
    Type: Application
    Filed: May 9, 2012
    Publication date: August 30, 2012
    Applicant: ROCHE DIAGNOSTICS INTERNATIONAL AG
    Inventors: Ruedi Zihlmann, Ronny-Patric Horisberger, Daniel Fehlmann
  • Publication number: 20120220953
    Abstract: Medicament delivery device comprising relatively movable housing parts, a medicament container,a proximal plunger rod part and distal plunger rod part in threaded engagement with each other, wherein said proximal plunger rod part is movably arranged in relation to said housing part sand in contact with a stopper of said medicament container, a lever pivotally attached to said housing parts and to the distal plunger rod part. The housing parts are ergonomically shaped having a grip-size for achieving a full hand grip and wherein said distal housing part and said proximal housing part are operably interconnected to each other through said lever such that a relative movement of said housing parts is capable of operating the lever for setting and injecting a dose.
    Type: Application
    Filed: October 29, 2010
    Publication date: August 30, 2012
    Applicant: SHL GROUP AB
    Inventor: Anders Holmqvist
  • Patent number: 8246584
    Abstract: An intraosseous injection device includes a tool having a distal portion, a proximal portion, and a solution dispensing opening. The distal portion has one or more cutting surfaces. The tool can be coupled with a protective carrier. The tool can be rotatably coupled to a tool actuation mechanism. A housing has a distal end and a proximal end. The housing releasably receives a solution cartridge containing a solution. A solution dispensing mechanism dispenses solution from the solution cartridge. A gripping member grips a proximal portion of the tool. A rotation device rotates the gripping member and thereby rotates the tool about an axis. The proximal portion of the tool connects directly to the solution cartridge such that solution from the cartridge can be delivered through the solution dispensing opening. The tool is configured to rotate relative to the solution cartridge.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: August 21, 2012
    Assignee: W&H Dentalwerk B├╝rmoos GmbH
    Inventors: Ines M. Aravena, Ajay Kumar, Hamid Abedi
  • Publication number: 20120209213
    Abstract: An assembly for a drug delivery device comprises a housing having a proximal end and a distal end, a dose button configured to be moved with respect to the housing for setting and delivering a dose of a drug, and a resilient setting member. For a dose delivery movement, the dose button is arranged to be moveable in the distal direction with respect to the housing from a dose delivery position, thereby deforming the resilient setting member to store energy in the resilient setting member. The assembly is configured to use the energy stored in the resilient setting member for a dose setting movement to move the dose button in the proximal direction with respect to the housing into the dose delivery position. Furthermore, a drug delivery device is provided.
    Type: Application
    Filed: December 5, 2011
    Publication date: August 16, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Axel Theucher
  • Publication number: 20120203184
    Abstract: An administering device, e.g. an injection device, includes a housing, a reservoir for a drug, the reservoir formed or accommodated by the housing, a dosing member which can perform a dosing movement relative to the housing for setting a dosage of the drug to be administered and a conveying member for delivering the dosage set, wherein the dosing member is blocked or locked in the direction of the dosing movement in a releasable dosing blocking engagement in an initial state of the administering device and released from the block at the end of a priming movement of the conveying member.
    Type: Application
    Filed: December 22, 2011
    Publication date: August 9, 2012
    Inventors: Anjan Selz, Manfred Rettenbacher, Fritz Kirchhofer
  • Patent number: 8226618
    Abstract: An injection device comprising: a base member (102); a plunger (104) for driving a piston in a distal direction; a driving member (106); and a gear mechanism (108) providing a gearing between the driving member (106) and the plunger (104) such that then the driving member (106) is moved at a first speed relative to the base member (102), the plunger (104) is moved at a second speed relative to the base member (102); wherein at least two of the base member (102), the plunger (104) and the driving member (106) are pivotally connected to the gear mechanism (108).
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: July 24, 2012
    Assignee: Novo Nordisk A/S
    Inventor: Thomas Geertsen
  • Patent number: 8226631
    Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: July 24, 2012
    Assignee: Sanofi Aventis Deutschland GmbH
    Inventors: Malcolm Boyd, Richard Letham, David Plumptre, Robert Veasey, James May
  • Patent number: 8216193
    Abstract: A plurality of dosage-control members are detachably connected to the plunger rod of a multi-dose syringe along two opposing sides of the rod. Each dosage-control member has a cut in which the external diameter of the top rim of the syringe fits to prevent forward and reverse movement of the rod. Removal of one dosage-control member from one of the two opposing sides of the rod permits forward movement of the rod and plunger until the top rim snaps into the cut of another dosage-control member. Flexible salient arms extend obliquely from the rod in one-to-one correspondence with the dosage-control members to prevent reverse movement of the rod.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: July 10, 2012
    Inventor: Jose Santiago Rolla
  • Publication number: 20120172815
    Abstract: The present invention relates to a medicament delivery device comprising an elongated housing (10, 10?) having opposite distal and proximal ends, a medicament container (18; 18?) arranged inside said housing, a medicament delivery member (16; 16?) attachable to said medicament container; a plunger rod (22; 22?) arranged to act on a stopper (20; 20?) inside said medicament container; driving means arranged to interact with said plunger rod; wherein said device further comprises an operation member (38; 38?) transversally protruding through an elongated opening (39; 39?) on the longitudinal surface of the elongated housing and interactively connected to the driving means for both setting and actuating the delivery of a dose of medicament.
    Type: Application
    Filed: March 29, 2010
    Publication date: July 5, 2012
    Applicant: SHL GROUP AB
    Inventor: Anders Holmqvist