Abstract: The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.

Abstract: An intraosseous injection device includes a tool having a distal portion, a proximal portion, and a solution dispensing opening. The distal portion has one or more cutting surfaces. The tool can be coupled with a protective carrier. The tool can be rotatably coupled to a tool actuation mechanism. A housing has a distal end and a proximal end. The housing releasably receives a solution cartridge containing a solution. A solution dispensing mechanism dispenses solution from the solution cartridge. A gripping member grips a proximal portion of the tool. A rotation device rotates the gripping member and thereby rotates the tool about an axis. The proximal portion of the tool connects directly to the solution cartridge such that solution from the cartridge can be delivered through the solution dispensing opening. The tool is configured to rotate relative to the solution cartridge.

Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract: The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.

Abstract: A medicament delivery device includes distal and proximal housings; a medicament container having a slidable stopper partially, slidably arranged within the proximal housing; a plunger rod within the distal housing having a proximal end abutting the stopper; a driver within the distal housing operably connected to the plunger rod for driving the plunger rod and stopper toward the device's proximal end; and a priming device having a distal end including an engagement mechanism arranged to cooperate with an engagement mechanism at the housing's proximal end, an end wall abutting the container's proximal end, and a passage on the end wall. An engagement mechanism at the priming device's proximal end cooperates with a delivery member engagement mechanism. Distal displacement of the priming device relative to the proximal housing causes distal displacement of the container relative to the plunger rod, forcing proximal displacement of the stopper, thereby priming the container.

Abstract: A pen injection device designed for use with dual or multi-chamber cartridges (14), is provided with an extended length plunger (24) having a non-drive portion (24?) on its forward end and the usual screw-threaded drive portion (24?) on its rearward end. This arrangement allows the plunger to be pushed forwardly whilst the dosing drive mechanism is disengaged to effect a reconstitution movement of the rearward bung (18?) in the cartridge. Thereafter the threaded portion on the plunger (24?) engages the drive mechanism to allow metered dosing.

Abstract: A housing for a dispensing apparatus. The housing comprising a main housing and a dose dial sleeve. The dose dial sleeve comprising a helical groove configured to engage a threading provided by the housing. A dose knob is disposed near a proximal end of the dose dial sleeve and a piston rod is provided within the housing. The piston rod is non-rotatable during a dose setting step. A driver comprises an internal threading near a distal portion of the driver and is adapted to engage an external thread of the piston rod. A tubular clutch is located adjacent a distal end of the dose knob and operatively coupled to the dose knob. The dose dial sleeve may extend circumferentially around at least a portion of the tubular clutch.

Abstract: A device for mixing a substance comprised of two constituents contained in a cartridge (12) and having a cartridge holder (32) thereabout, the device comprising a plunger rod (46) for pushing a closure member (20) to permit the transfer of a diluent in a second chamber (28) through a by-pass channel (24) to mix with a constituent in a first chamber (26), the plunger rod (48) being driven by means of a rack (48) and a pinion gear (50) arrangement to prevent overly rapid movement of the plunger rod (46).

Abstract: A hand-held remote for a medical fluid injector includes a syringe and a conduit which may be coupled to a pressure transducer on a control circuit of the injector. Movement of a plunger within a syringe body on the syringe creates a pressure which is sensed by the pressure transducer and the control circuit responds to the sensed pressure by causing fluid to be ejected from, or drawn into, a syringe mounted to the injector. The pressure developed by the remote provides tactile feedback to an operator for improved control over injections.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: A dosing device for an injection device, the dosing device including an actuating element for adjusting and/or dispensing a dose from the injection device, a thrust element for generating a forward movement for discharging a dose and a coupling to which the actuating element and the thrust element are coupled such that a rotational movement of the actuating element is transmitted directly to the thrust element and an axial movement of the actuating element is different than an axial movement of the thrust element.

Abstract: A dispenser device comprising a pistol housing, a needle direction control mechanism, a boost mechanism, a quantification control mechanism, and a combination of a housing, a needle direction control mechanism, a boost mechanism, and a syringe positioning mechanism or a holding ring embodies the present invention with features and advantages shown as follows, (1) Uniform injection of agents synchronously mixed by not less than two contents; (2) Mixed agents not exposed in air; (3) Uniform injection, high air tightness, injection direction controlled by easy turning, smooth and convenient operation, high powerful operation via shifts of a push rod driven by a pressed trigger, promoted yield rate, assembly easily constructed, reduced manufacture cost, and convenient maintenance.

Abstract: A syringe (10) has a plunger (20), a barrel (11) and a collar (40, 50) with two pawls (42A, 42B). The plunger has two opposed ratchets (23A, 23B) that align with the one each of the pawls and thereby or impede, withdrawal of the plunger during or following depression of the plunger. The barrel has a collar with an inner (50) and an outer member (40) that are incapable of rotation relative with respect to each other. The outer member has the two pawls (42A, 42B) and two fingers that slidably engage opposed guide slots (28) on the plunger to thereby prevent or minimize rotation of the plunger relative to the collar. The inner member of the collar is operable to prevent engagement of the plunger ratchet by the two pawls until the plunger is depressed.

Abstract: An additive force device (111) is connectible with a drug delivery device (100) to increase the amount of force exerted by a user on the dose setting knob (24) to facilitate injection. The additive force device (111) includes a first spring (121) and a loading barrel (135) connected to the first spring (121) for storing torque therein. A ratchet assembly (129) is connected to the loading barrel (135) and to the first spring (121). The ratchet assembly (129) has a first position in which torque is stored in the first spring (121) and a second position in which torque is released from the first spring (121). An inner barrel (133) is connected to the ratchet assembly and to the drug delivery device (100). The inner barrel (133) transmits the stored torque from the first spring (121) to the drug delivery device (100) to increase an injection force thereof.

Abstract: A dose metering mechanism for use in administering doses of an injectable product from an injection device, the dose metering mechanism including a rack with teeth, a feed sleeve displaceable relative to the rack, a first catch element associated with the feed sleeve for latching in the teeth of the rack, a guide piece relative to which the rack is movable, a second catch element associated with the guide piece for latching in the teeth of the rack, and a latching control device associated with the toothed rack for controlling the latching of at least one of the first and second catch elements in the teeth of the rack. A method of preparing to administer and administering doses of an injectable product from an injection device including the dose metering mechanism is encompassed.

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set the delivery dose. The injector may include a housing, a cartridge containing medicinal product, the cartridge being retained within the housing, means for selecting a dose of medicinal product to be expelled, and means for expelling the selected dose of medicinal product. The housing may be a unitary housing within which the means for selecting a dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston may rotate, a ratchet, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and a clutch which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: A medical injector is provided herein having a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided formed to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally towards a distal end of the body but not proximally towards a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger thereby allowing the engagement portion to by-pass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector.

Abstract: A medical injector has a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally toward a distal end of the body but not proximally toward a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger, thereby allowing the engagement portion to bypass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector.

Abstract: A device for administering a fluid product including a housing, a conveying device for the product, a coupling element provided for the drive of the conveying device and which can be rotated about a rotational axis, a first blocking element connected in a rotationally secure manner to the coupling element, a second blocking element detachably engageable with the first blocking element thereby preventing a rotational movement thereof in the drive direction and enabling said rotational movement to take place in the counter dosing direction, a torsion spring connected to the coupling element such that it is stressed by the rotational movement when the blocking elements are engaged in a blocked position and drives the coupling element in a rotary manner after the blocking position is released, and a release element coupled to at least one of the blocking elements such that a release movement of the release element displaces at least one of the blocking elements from the blocked position, the release element also

Abstract: A drug delivery pump drive which uses a linear piezoelectric motor to advance a syringe piston to deliver a liquid drug and a method thereof are disclosed. The pump drive, provided in a drug delivery pump, provides silent operation and very low energy consumption compared to electric motor-based drives. The small size of the motor helps also to reduce overall size of the pump drive and the resulting drug deliver pump.

Abstract: The present invention relates to a medicament delivery device comprising a generally tubular distal housing part (18); a generally tubular proximal housing part (12) releasibly connected to said distal housing part; a medicament container (70) having opposite proximal and distal ends and a slidable stopper, wherein the container is partially and slidably arranged within the proximal housing part; a plunger rod (72) having opposite proximal and distal ends and being arranged within said distal housing, wherein the proximal end of the plunger rod is abutting the stopper of the container; drive means arranged within said distal housing and being operably connected to said plunger rod for driving said plunger rod and thereby said stopper towards the proximal end of the device; characterised in that the device further comprises a priming device (34) having a distal end comprising tune engagement means (38) arranged to cooperate with corresponding tune engagement means (24) arranged at the proximal housing, an end

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.

Abstract: A pen-type injector is improved so that a user may select a delivery dose of medicinal product from a multidose cartridge. The injector includes a housing. a cartridge containing medicinal product retained within a housing, a piston rod, a dose selecting member to select a dose of medicinal product to be expelled, and a drive member to expel the selected dose of medicinal product. The housing is formed unitary so that the dose selecting member and the drive member are moveably retained within the housing. The injector may include ratchet means associated with the insert to ensure the piston rod only rotates in a single direction through the insert, a button located on the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: A threaded rod for an injection device, wherein the rod includes a thread on an external surface, the thread supporting or carrying, at least partially, engaging elements and/or teeth. In one embodiment, the present invention encompasses a dosing mechanism for an injection device, including a rotational defining element which enables a threaded rod to be rotated in one direction, rotation being blocked or prevented in the counter direction by at least one blocking element which co-operates with a thread of the threaded rod, wherein the thread carries, supports or has associated teeth and/or engaging elements. In one embodiment, the present invention encompasses an injection device including at least one engaging element which co-operates with a blocking element associated with a threaded rod, whereby the threaded rod is rotatable in one direction in relation to the injection device, rotation in the opposite direction being prevented.

Abstract: Embodiments disclosed herein relate to syringe systems for delivering and removing materials, instrument kits that include the syringe systems provided herein, and methods of using the syringe systems and kits provided herein.

Abstract: An administering apparatus for administering a fluid product, including a casing, a reservoir for the product, a driven device which acts on the product contained in the reservoir to deliver the product, and a drive device which acts on the driven device and performs a delivery stroke in a drive direction from a delivery position up to a delivery stopper to deliver a product dosage to be administered, wherein a priming stopper is provided for the drive device and limits a priming stroke of the drive device, which serves to bleed, in the drive direction, wherein the priming stroke is axially shorter than a maximum delivery stroke, and wherein the drive device can be moved in the drive direction from a priming position up to the priming stopper and transversely to the drive direction as far as the delivery position.

Abstract: Disclosed is an ultra-low dose injection delivery system. The system includes a pistol grip having front and rear handles, a barrel containing an injectable fluid, and a bottle mount integrated with the barrel for receiving and securing a bottle holder, the bottle mount including a conduit running from a spike tip that punctures a bung of the bottle into the barrel. The system further includes a needle coupling attached to the barrel adapted to receive and secure a needle and a plunger for assisting in drawing an injectable fluid from a bottle into the barrel and for forcing the injectable fluid out of the barrel. A ratcheting mechanism incrementally advances a selectable ultra-low dose of injectable fluid out of the barrel upon a full stroke of the pistol grip. A full stroke is defined as advancing the plunger forward by squeezing the front and rear handles together until the ratcheting mechanism stops the plunger from further advancing yet still allows the front and rear handles to be fully squeezed.

Abstract: A hand-held device (10) useful for dispensing a liquid material includes a housing (11) containing the material to be dispensed and having a dispensing nozzle (12) and a resettable ratchet (13, 50) operatively connected to a biased piston (30). The ratchet mechanism (13, 50) including a release lever (13) normally preventing movement of the piston (30) until released. When the lever (13) is released the piston (30) is biased toward the dispensing nozzle (12), such that an amount of the material is urged to flow toward the nozzle (12). The housing (11) is configured to be pen-like.

Abstract: A device for the dosed administration of an injectable product, including a housing with a receptacle for the product and a drive mechanism movable via a dosing element supported displaceably in the housing, wherein the drive mechanism includes engagement elements situated together in groups, the distance between the groups corresponding to a dosing amount of the injectable product and the distance between the engagement elements corresponding to a priming amount of the injectable product, and wherein the dosing element is coupled to the drive mechanism so that the dosing element at one time interacts with a group of engagement elements to administer the dosing amount and at another time interacts with an engagement element to release the priming amount.

Abstract: A drive mechanism for an injection device is disclosed in which piston means are selectively driven to expel medicament from within a medicament cartridge. The drive mechanism comprises a drive means associated with a first ratchet member, a second ratchet member associated with the piston means, a housing, the first ratchet member and the second ratchet member being disposed within the housing. The second ratchet member being biased by biasing means toward the first ratchet member. The drive means is actuable reciprocally to drive the first ratchet member in a first angular direction such that the first ratchet member drives the second ratchet member along its longitudinal axis against the biasing means along at least a part of its movement and subsequently drives the first ratchet member and the second ratchet member together in a second angular direction thereby to drive the piston means.

Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.

Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.

Abstract: An injection device for injecting selectable amounts of a substance includes an activating mechanism including an axially moveable operating button which can rotated in a resting position only, a tubular drive element non-rotatably connected to the operating button, an axially fixed and non-rotatable guiding element, and an axially moveable driven member held non-rotatably in the device. A rotational grid is operationally between rotatable and non-rotatable components of the injection device such that the operating button can be moved two rotational directions when in the resting position whereby a selected amount of the substance to be injected can be selectively varied. For example, a dosage inadvertently selected too large by rotating the operating button too far in one direction can, in accordance with the present invention, be reduced by rotating the operating button in the opposite direction.

Abstract: A controlled volume injection/aspiration device includes a syringe having a body for containing a medicament, a needle and a piston slidably disposed within the body. A shell is provided for receiving the syringe body and a plunger rack is disposed within the shell. A manually operated control is disposed in an operative relationship with the plunger rack for moving the plunger rack in a stepwise forward direction causing the piston to eject discrete doses of medication from the syringe body through the needle. The manual operated control is also operative for moving the piston in a stepwise reverse direction causing the piston to aspirate fluid into the syringe body through the needle.

Abstract: The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.

Abstract: The present invention is directed to an assembled syringe for administering powder medicament in the field of medicine. By using a connecting tube, a solvent bottle containing diluent communicates with a solute bottle containing powder by external force, and the diluent is injected into the solute bottle through the connecting tube under pressure. After the powder is dissolved and mixed uniformly, the mixed solution is injected directly into a patient or added to a transfusion bottle or tube. Both the solvent and solute bottles are packaged into a sleeve to avoid contamination. Buckles on the plunger sleeve are fitted into restricting slots on the sleeve. The fitting of the slots and buckles restricts the position of the syringe, self-locking and controlling the magnitude of force by which the solute bottle is communicated with the solvent bottle, controlling the depth of insertion of the needle into the body, and preventing misoperation or damage during transport, fetching and using.

Abstract: A syringe is provided for limiting the dosage of medication delivered to a patient to a pre-determined amount. The syringe assembly includes an injector assembly and vial of medication. The injector assembly has an adjustable dosage control which rides in a track on the injector assembly for limiting vial movement. Once an appropriate dosage is selected using the dosage control, the vial is engaged with the injector assembly. As the vial is pressured into the injector assembly medication is forced through the needle. Once the vial reaches the dosage control, vial movement is obstructed and dosage effectively limited.

Abstract: A syringe (10) has a plunger (20), a barrel (11) and a collar (40, 50) with two pawls (42A, 42B). The plunger has two opposed ratchets (23A, 23B) that align with the one each of the pawls and thereby or impede, withdrawal of the plunger during or following depression of the plunger. The barrel has a collar with an inner (50) and an outer member (40) that are incapable of rotation relative with respect to each other. The outer member has the two pawls (42A, 42B) and two fingers that slidably engage opposed guide slots (28) on the plunger to thereby prevent or minimize rotation of the plunger relative to the collar. The inner member of the collar is operable to prevent engagement of the plunger ratchet by the two pawls until the plunger is depressed.

Abstract: A controlled volume injection/aspiration device includes a syringe having a body for containing a medicament, a needle and a piston slidably disposed within the body. A shell is provided for receiving the syringe body and a plunger rack is disposed within the shell. A manually operated control is disposed in an operative relationship with the plunger rack for moving the plunger rack in a stepwise forward direction causing the piston to eject discrete doses of medication from the syringe body through the needle. The manual operated control is also operative for moving the piston in a stepwise reverse direction causing the piston to aspirate fluid into the syringe body through the needle.

Abstract: A controlled volume injection/aspiration device includes a syringe having a body for containing a medicament, a needle and a piston slidably disposed within the body. A shell is provided for receiving the syringe body and a plunger rack is disposed within the shell. A manually operated control is disposed in an operative relationship with the plunger rack for moving the plunger rack in a stepwise forward direction causing the piston to eject discrete doses of medication from the syringe body through the needle. The manual operated control is also operative for moving the piston in a stepwise reverse direction causing the piston to aspirate fluid into the syringe body through the needle.

Abstract: A veterinary syringe comprises a base body for receiving a syringe barrel with a guiding element for a plunger rod that is guided therein so as to be movable in a longitudinal direction. At one end of the plunger rod, a plunger is attached that extends into the syringe barrel. The syringe further comprises a handle and an operating lever. The operating lever is connected to a guiding element that engages with a toothed rack associated with the plunger rod, and with a locking device for the plunger rod that engages with the toothed rack. The locking device acts as a locking slider disposed inside the guiding element and has an opening through which the plunger rod is guided and extends into the toothed rack from below, locking the toothed rack so as to prevent it from withdrawing.

Abstract: A fluid dispenser device comprising a body (1), dispensing means (30) for dispensing the fluid, a first reservoir (10) containing a first fluid and a second reservoir (20) containing a second fluid, the first and second fluids being to be mixed prior to dispensing so as to form one or more doses of fluid to be dispensed, said fluid dispenser device being characterized in that it further comprises a mixture-forming system for mixing the first and second fluids in one of said reservoirs (10, 20), said mixture-forming system having a manual actuating element (50) that is mounted to move in a direction that is substantially perpendicular to the direction in which the fluid is dispensed, said manual actuating element (50) being actuatable with one hand and acting, after said first and second fluids have been mixed, to actuate the dispensing means (30) for dispensing the fluid, without any further manipulation of the device being necessary.

Abstract: A hand-held device (10) useful for dispensing a liquid material includes a housing (11) containing the material to be dispensed and having a dispensing nozzle (12) and a resettable ratchet (13, 50) operatively connected to a biased piston (30). The ratchet mechanism (13, 50) including a release lever (13) normally preventing movement of the piston (30) until released. When the lever (13) is released the piston (30) is biased toward the dispensing nozzle (12), such that an amount of the material is urged to flow toward the nozzle (12). The housing (11) is configured to be pen-like.

Abstract: A gas-powered, durable, needle-less hypodermic jet injection device (10, 210) includes a hand-held injector (12, 212) which receives into an injection cylinder a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its usability, particularly for users with hands that are possibly weak, feeble, or arthritic, for example; and also includes additional features which improve manufacturability, durability, and cost effectiveness of the device.

Abstract: The invention refers to a device for administering an injectable product in doses, comprising a casing, itself comprising: a reservoir for the product; a piston which forces product out of the reservoir when moved in a feed direction towards a reservoir outlet; a drive member; a driven member which is slaved by the drive member when the drive member is moved in the feed direction, so moving the piston in the feed direction; and a dosing member which may be rotated about the sliding axis of the drive member, to set the product dosage to be administered. The drive member and the dosing member abut each other via at least one dosage stopper each, one of which is provided on the drive member and the other on the dosing member. At least one of these dosage stoppers at least partially encircles the sliding axis of the drive member in the form of a spiral. The at least one spiral dosage stopper exhibits a continuous course with a constant pitch &agr;.

Abstract: A system, method and apparatus are provided for administering medical liquids to a patient. The invention is particularly apt for use in the intravenous administration of multiple doses of a flush solution over an extended period of therapy. In certain aspects of the invention methods and apparatus are directed to the provision and utilization of a packaged syringe filled with a medical liquid and having a tubing length interconnected thereto, wherein the volume of pre-filled medical liquid is sufficient to allow for multiple administrations to a given patient. By way of primary example, where the syringe is pre-filled with a flush solution, a volume of at least about 40 ml. is preferred. In other aspects, methods and apparatus are directed to the administration of medical liquids from a pre-filled syringe utilizing an apparatus that is particularly adapted for administering a medical liquid in successive increments over a plurality of separated time intervals.

Abstract: The invention concerns a device for administering an injectable product in doses, wherein the device includes a casing, comprising a reservoir for the product, a piston, which when moved in a feed direction towards an outlet of the reservoir forces product from the reservoir, a gear rack, moving the piston in the feed direction, comprising a first series of teeth and a second series of teeth, a drive member, movable relative to the casing in and counter to the feed direction, and slaving the gear rack when moved in the feed direction, and a blocking means, arranged secured against shifting relative to the casing and cooperating with one of the series of teeth such that it prevents the gear rack from being moved counter to the feed direction and allows the gear rack to be moved in the feed direction.

Abstract: The present invention provides a novel apparatus for delivering a liquid or gel-like surgical material to a target site within a body cavity. The apparatus is characterized in part by an elongated structural member adapted for engagement with a conventional syringe and cannula assembly. In preferred embodiments of the present invention, devices of the invention further comprise a highly flexible applicator tip which permits application of the surgical material at variable delivery angles and even against gravity. Methods also are disclosed for applying the surgical material to the target site using. devices of the present invention.

Abstract: Injector devices and methods for their operation for containers having an opening with or for an injection needle. The container is optionally of syringe type with a barrel of substantially constant axial cross-section. In one embodiment, the devices include a penetration arrangement operable to move the needle from a rear position to a forward position, an injection arrangement operable at least to expel container content through the needle, and a transmission and a switch system allowing manual energy applied to the device to manually operate the penetration arrangement and then manually operate the injection arrangement.