Means For Reducing Piston Sliding Friction (e.g., Oil Applicator, Use Of Low Friction Material, Etc.) Patents (Class 604/230)
  • Patent number: 10143804
    Abstract: A stable biopolymer-based emulsion lubricant including Agar is provided to reduce the friction between a syringe barrel plunger and the interior surface of the syringe barrel. According to exemplary embodiments the emulsion has a friction of less than 4N, the emulsion is temperature stable in a range of 4-23 degrees Celsius and the emulsion is stable for a period of at least 60 days.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: December 4, 2018
    Assignee: ZebraSci, Inc
    Inventors: Frederick Talley Gertz, Jaan Noolandi, Robert James Schultheis
  • Patent number: 9327080
    Abstract: A piston for a medical hollow body such as a syringe or a carpule includes at least one sliding surface for contact with the hollow body. The piston has at least one receiving area in which a lubricant can be received, and at least one dispensing mechanism for dispensing the at least one lubricant from the at least one receiving area to the at least one sliding surface.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: May 3, 2016
    Assignee: ARZNEIMITTEL GMBH APOTHEKER VETTER & CO. RAVENSBURG
    Inventors: Frank Boettger, Benjamin Boebst
  • Patent number: 9220631
    Abstract: The present invention relates to a syringe, particularly to a small volume syringe such as a syringe suitable for ophthalmic injections.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: December 29, 2015
    Assignee: Novartis AG
    Inventors: Juergen Sigg, Christophe Royer, Andrew Mark Bryant, Heinrich Martin Buettgen, Marie Picci
  • Patent number: 9108012
    Abstract: Medical articles with coatings are disclosed herein, as well as methods and systems for depositing these coatings onto medical articles. Surfaces of such articles may be coated. The coating(s) may serve as lubricants for reducing suction between such surfaces or between a coated surface and another surface.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: August 18, 2015
    Assignee: GVD Corporation
    Inventors: Hilton G. Pryce Lewis, Neeta P. Bansal, Erik S. Handy
  • Patent number: 9089637
    Abstract: A plunger head moveable in an axial direction within a reservoir having an interior volume for containing fluidic media may have a first portion in contact with fluidic media when fluidic media is in the interior volume of the reservoir, the first portion comprising a first material compatible with fluidic media in the interior volume of the reservoir, a second portion located on an opposite side of the plunger head from the interior volume of the reservoir, the second portion connectable to a plunger arm, and a third portion located between the first portion and the second portion of the plunger head, at least one of the first portion, second portion, and the third portion is made of a material that comprises one of a cyclic olefin copolymer and a cyclic olefin polymer.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: July 28, 2015
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Colin A. Chong, Eric M. Lorenzen, Rafael Bikovsky, Truong Gia Luan, Arsen Ibranyan
  • Publication number: 20150126941
    Abstract: A method for providing a saccharide based lubricating or protective coating or layer on a substrate surface is provided. In particular, a lubricity and/or protective coating or layer made by said method is provided. Pharmaceutical packages or other vessels coated by said method and the use of such pharmaceutical packages or other vessels protecting a compound or composition contained or received in said vessel with a protective coating against mechanical and/or chemical effects of the surface of the vessel without a protective coating material are also provided.
    Type: Application
    Filed: May 9, 2013
    Publication date: May 7, 2015
    Applicant: SiO2 Medical Products, Inc.
    Inventors: John T. Felts, Thomas E. Fisk, Robert S. Abrams, John Ferguson, Jonathan R. Freedman, Robert J. Pangborn, Peter Sagona, Christopher Weikart, Jacob Israelachvili
  • Patent number: 8968260
    Abstract: A gasket for use in a syringe so formed as to liquid-tightly and slidably contact an inner surface of an outer cylinder of the syringe, the gasket including a gasket body made of an elastic body and a coating layer formed on a portion thereof which contacts at least the syringe, wherein the coating layer includes a composition containing a silicone resin which comprises a condensate of a reactive silicone resin having a terminal silanol group and which has a siloxane bond derived from the silanol group, and does not contain solid fine particles.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: March 3, 2015
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Aiko Horiuchi, Eiji Watanabe, Shigeru Suzuki, Masami Shimoda
  • Publication number: 20150018800
    Abstract: Pre-loaded syringes for delivering an embolic agent are disclosed herein. Methods related to syringes pre-loaded with an embolic agent are also disclosed.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Inventors: Philippe Reb, Peter C. Sutcliffe
  • Patent number: 8900205
    Abstract: An object of the present invention is to provide a syringe for prefilled syringe in which the adsorption of a low-molecular medical agent or a protein for a long term is precluded. In accordance with the present invention, the above-described object is achieved by a syringe for prefilled syringe including: a plunger in which a gasket is attached to a top; and a syringe barrel in which the plunger is slidably accommodated, wherein the surface of the gasket and the inner wall of the syringe barrel are subjected to surface modification with a polymer containing zwitterion.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: December 2, 2014
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Naoki Ishii
  • Patent number: 8876783
    Abstract: The present invention relates to a medicament delivery device comprising a housing (12); a medicament container (14) arranged within said housing; medicament delivery drive means (22, 24); manually operable release means (38); and a movement speed control mechanism (44, 46, 48) comprising at least one fixed, flexible and elongated compartment (48) containing a liquid, and at least one flexible speed control member (44, 46) connected to the medicament delivery drive means; wherein said at least speed control member is arranged to be pressing on said at least one compartment for forcing said liquid past said member and thereby creating a movement speed control of said medicament delivery drive means when moved.
    Type: Grant
    Filed: November 26, 2009
    Date of Patent: November 4, 2014
    Assignee: SHL Group AB
    Inventor: Anders Holmqvist
  • Patent number: 8845592
    Abstract: The present invention relates to a medicament delivery device (10) comprising a front housing (12) and a rear housing (14) connected to each other; a medicament container (18) disposed within the front housing (12), wherein the container (18) has a front opening with or for a delivery member for delivering the medicament therethrough and at least one movable stopper (25); and a compression spring (26) having a predetermined compressed length and a predetermined outer diameter, wherein the compressed length is the length of the spring when it is in a pre-tensioned state; wherein the device further comprises a first guide means comprising a front part (28) having a predetermined first length (61), a middle part (42) having a predetermined second length (62), and a rear part (34) having a predetermined third length (63), wherein said predetermined third length corresponds to the predetermined compressed length of the compression spring, wherein the front part (28) is arranged to be in contact with the movable st
    Type: Grant
    Filed: November 26, 2009
    Date of Patent: September 30, 2014
    Assignee: SHL Group AB
    Inventor: Anders Holmqvist
  • Publication number: 20140249484
    Abstract: An article is described including an article surface, a primer coating or layer of SiOx, SiOxCy or SiNxCy applied to the article surface, and a deposit of lubricant applied to the primer coating or layer. The primer coating or layer of SiOx, SiOxCy or SiNxCy is applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. A first deposit of lubricant is applied to the primer coating or layer. The primer coating or layer improves the adhesion or wetting of the lubricant on the surface to be lubricated. Examples of such an article are a prefilled syringe having a barrel with a lubricated interior portion and a plunger tip that slides along it. Another example of such an article is a vial having a lubricated opening to receive a septum. Another aspect of the invention is a method of making such an article.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 4, 2014
    Applicant: SIO2 MEDICAL PRODUCTS, INC.
    Inventors: Joseph A. Jones, Christopher Weikart, Steven J. Martin
  • Patent number: 8764703
    Abstract: In a pre-filled syringe having an intermediate gasket, a liquid drug is enclosed in the second chamber located on the base end side with respect to the intermediate gasket while a powdered drug is enclosed in the first chamber located on the front end side with respect to the intermediate gasket. The intermediate gasket has at least two layers including a front end layer corresponding to a wall of the first chamber and a base end layer corresponding to a wall of the second chamber, and also has a low water-absorptive layer in the layer on the base end side with respect to the front end layer. The base end layer is formed of a material having low water-absorptivity and not lowering a pH of the liquid drug.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: July 1, 2014
    Assignee: Nipro Corporation
    Inventors: Takashi Asai, Tsutomu Takahashi, Kenyu Ito, Atsushi Ishikawa
  • Patent number: 8740856
    Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with the main body adjacent the closed front end. The core member includes a nose portion having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 3, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Michael Vincent Quinn, Eric Schiller, Gang Ju, E Guan
  • Patent number: 8668972
    Abstract: Medical articles with coatings are disclosed herein, as well as methods and systems for depositing these coatings onto medical articles. Surfaces of such articles may be coated. The coating(s) may serve as lubricants for reducing stiction between such surfaces or between a coated surface and another surface.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: March 11, 2014
    Assignee: GVD Corporation
    Inventors: Hilton G. Pryce Lewis, Neeta P. Bansal, Erik S. Handy
  • Publication number: 20140052076
    Abstract: The present invention provides rubber sealing members having an exterior surface adapted to sealingly engage an inner surface of a chamber of a medical device, the exterior surface of the sealing member having a coating thereon prepared from a curable composition including: (a) a first organopolysiloxane having at least two alkenyl groups; and (b) a second organopolysiloxane having at least two pendant hydrogen groups, the second organopolysiloxane being different from the first organopolysiloxane, wherein at least one of the first organopolysiloxane, the second organopolysiloxane or an optional third organopolysiloxane of the curable composition comprises a fluoro group.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: Becton, Dickinson and Company
    Inventors: Xia Zhao, Yongming Liu
  • Patent number: 8632508
    Abstract: A pressurized injection device comprises a mechanical loading mechanism comprising a double set of rackets (17,18) and ball bearings/pins running in a curved track (20) which enables a resilient element (7) to be pre-stressed by—twisting the two outer house parts of the device relative to each other back and forth. When twisted in one direction one set of rackets (17) engages the teeth of the piston rod (9) connected to the resilient element and when twisted in the opposite direction, the other set of rackets (18) engages same piston rod. The resilient element is set off to engage a plunger of a container holding a drug to be injected by pressing the release button (1), which can be secured by a safety switch.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: January 21, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Torben Stroem Hansen, Matias Melander
  • Publication number: 20130338606
    Abstract: In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.
    Type: Application
    Filed: August 16, 2013
    Publication date: December 19, 2013
    Applicant: MOMENTIVE PERFORMANCE MATERIALS INC.
    Inventors: Samuel Conzone, David M. Rusinko, Chandrashekar Raman, Indumathi Ramakrishnan, Anantharaman Dhanabalan, Mayank Kumar Dubey, Markus Bley, Hans Rafael Winkelbach
  • Patent number: 8551054
    Abstract: The present invention relates to damper for a medicament delivery device, which device comprises a container containing medicament, a stopper arranged in said container and movable for expelling said medicament through a dose delivery means, a plunger rod having opposing proximal and distal ends and capable of acting on said stopper, and force means capable of exerting a force on said plunger rod, wherein said damper comprises a tubular sleeve having opposing proximal and distal ends; said sleeve comprises a compartment formed by a closed end wall at the proximal end of the sleeve and the proximal end of the plunger rod which is positioned in an open end at the distal end of the sleeve; and wherein said compartment comprises a sealable and resilient pad, a fluid, and at least one passage for expelling said fluid in an annular space between said sleeve and an inner wall of said container, thereby creating a dampening force, upon movement of said plunger rod.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: October 8, 2013
    Assignee: SHL Group AB
    Inventor: Carlos Guillermo
  • Patent number: 8540683
    Abstract: A syringe device and injector system including a vent for relieving a vacuum within a syringe is provided. Embodiments provide a syringe device including a reservoir having a sidewall. The reservoir includes a dispensing distal end a proximal end. The syringe device also includes a piston in movable sealing engagement with the sidewall. Furthermore, the sidewall defines a vent extending from the proximal end of the reservoir. The vent is configured to interrupt the sealing engagement between the piston and the sidewall so as to allow a gas to enter the reservoir through the proximal aperture and past the piston member as the piston member is moved from the distal end to the proximal end of the tubular aperture.
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: September 24, 2013
    Assignee: ACIST Medical Systems, Inc.
    Inventors: Robert C. Williams, Jr., Vito De Monte
  • Patent number: 8517997
    Abstract: A dispenser assembly for liquid products is disclosed. Such an assembly may include an elongated barrel, and an elongated plunger having a flexible sealing lip disposed at an end thereof. The sealing lip may have an outer diameter in a relaxed state that is greater than an internal cross-sectional diameter of the barrel. When the plunger and barrel are actuated axially relative to one another, the sealing lip flexes inwardly and provides the sole contact between the plunger and the barrel.
    Type: Grant
    Filed: February 12, 2008
    Date of Patent: August 27, 2013
    Assignee: Comar, Inc.
    Inventors: David A. Manera, John D. Buehler
  • Publication number: 20130211344
    Abstract: This invention relates to components useful for medical articles, such as a syringe assemblies, having sliding contact surface (s) coated with at least one coating layer, wherein the contact surface has an average surface roughness (Ra) ranging from about 10 nm to about 1700 nm and/or the coating layer has crystalline domains, the mass of the crystalline domains being at least about 20% of the total mass of the coating layer, and methods of making the same.
    Type: Application
    Filed: December 31, 2009
    Publication date: August 15, 2013
    Inventors: Nestor Rodriguez, Paolo Mangiagalli
  • Publication number: 20130209766
    Abstract: A method for coating a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising an organosilicon precursor and optionally O2. The lubricity, hydrophobicity and/or barrier properties of the coating are set by setting the ratio of the O2 to the organo silicon precursor in the gaseous reactant, and/or by setting the electric power used for generating the plasma. In particular, a lubricity coating made by said method is provided. Vessels coated by said method and the use of such vessels protecting a compound or composition contained or received in said coated vessel against mechanical and/or chemical effects of the surface of the uncoated vessel material are also provided.
    Type: Application
    Filed: May 11, 2011
    Publication date: August 15, 2013
    Inventors: John Felts, Tom Fisk, Robert Abrams, John Ferguson, Jonathan Freedman, Robert Pangborn, Peter Sagona
  • Publication number: 20130138050
    Abstract: The present invention relates to a drive mechanism for a drug delivery device, comprising a number of mechanically interacting functional components among which at least a piston rod is adapted to transfer thrust to a piston of a cartridge that contains a medicinal product to be dispensed, wherein at least one of the functional components at least in sections comprises a friction-reducing slide coating. In this way, a force level required for dispensing and/or setting of a dose can be effectively reduced.
    Type: Application
    Filed: May 3, 2011
    Publication date: May 30, 2013
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Jugl, Günther Sendatzki, Axel Teucher
  • Patent number: 8322577
    Abstract: A plunger for a syringe used to inject gas and liquid chromatography samples has an end portion surrounded by a flexible sleeve. The sleeve forms a seal in the bore of a barrel traversed by the plunger, the bore being in fluid communication with a cannula attached to the end of the barrel. The plunger has an end surface that is exposed and is flush with an annular end surface of the sleeve. The plunger end surface, and not the sleeve, contacts the cannula upon injection and avoids imposing cyclical hoop stresses on the barrel which tend to crack the barrel after a finite number of cycles. In a further embodiment, a thin layer of sleeve material covers the end surface of the plunger. The thin layer avoids inducing significant barrel stress.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: December 4, 2012
    Assignee: Agilent Technologies, Inc.
    Inventor: Ponna Pa
  • Patent number: 8308726
    Abstract: A system to minimize fluid turbulence inside a tissue cavity during endoscopic procedures. A body tissue cavity of a subject is distended by continuous flow irrigation using a solenoid operated pump on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by the outflow positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss into the subject's body system during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: November 13, 2012
    Inventors: Atul Kumar, Alka Kumar
  • Publication number: 20120172818
    Abstract: A first movable element (4) and a second movable element (7) of a mechanism in a medical device are arranged in such a manner that, during an operation of the mechanism, a surface of the first element slides on a surface of the second element. The first element and the second element are formed from materials providing a coefficient of sliding friction of said surfaces on one another of less than 0.14 at a relative velocity of 2 mm per second.
    Type: Application
    Filed: March 31, 2010
    Publication date: July 5, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Harms, Steffen Raab, Uwe Dasbach
  • Publication number: 20120143148
    Abstract: The present invention provides rubber sealing members having an exterior surface adapted to sealingly engage an inner surface of a chamber of the medical device, the exterior surface of the sealing member having a coating thereon prepared from a curable composition including: (a) a first organopolysiloxane having at least two alkenyl groups; and (b) a second organopolysiloxane having at least two pendant hydrogen groups, the second organopolysiloxane being different from the first organopolysiloxane, wherein at least one of the first organopolysiloxane, the second organopolysiloxane or an optional third organopolysiloxane of the curable composition comprises a fluoro group.
    Type: Application
    Filed: April 8, 2011
    Publication date: June 7, 2012
    Applicant: Becton, Dickinson and Company
    Inventors: Xia Zhao, Yongming Liu
  • Publication number: 20120101453
    Abstract: A piston for a medical hollow body such as a syringe or a carpule includes at least one sliding surface for contact with the hollow body. The piston has at least one receiving area in which a lubricant can be received, and at least one dispensing mechanism for dispensing the at least one lubricant from the at least one receiving area to the at least one sliding surface.
    Type: Application
    Filed: June 9, 2010
    Publication date: April 26, 2012
    Applicant: ARZNEIMITTEL GMBH APOTHEKER VETTER & CO. RAVENSBURG
    Inventors: Frank Boettger, Benjamin Boebst
  • Publication number: 20120065595
    Abstract: In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.
    Type: Application
    Filed: September 8, 2011
    Publication date: March 15, 2012
    Inventors: Samuel D. Conzone, David M. Rusinko, Chandrashekar Raman, Indumathi Ramakrishnan, Anantharaman Dhanabalan, Mayank Kumar Dubey, Sumi Dinkar, Mayanglambam Rebika Devi, Markus Bley
  • Patent number: 8100865
    Abstract: The invention comprises a disposable hypodermic syringe with means for passive aspiration. The syringe comprises a barrel (10) of clear synthetic plastics material and a plunger (12) comprising an elastic bung (28) slideable in the barrel (10). Pressure on the plunger elastically deforms the bung (28). If this pressure is released the bung (28) resiles to effect aspiration. This aspiration is passive, requiring no active withdrawal of the plunger by the user. After use the syringe may be disposed of as a whole, with no disassembly, using one hand only. The syringe may be made by adapting cartridges conventionally used for dental local anaesthetic.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: January 24, 2012
    Assignee: Hambley Limited
    Inventor: Leonard Morris Spofforth
  • Publication number: 20110252899
    Abstract: Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed, for example using material outgassed from a surface to inspect the properties of a surface coating.
    Type: Application
    Filed: June 27, 2011
    Publication date: October 20, 2011
    Inventors: John T. Felts, Thomas E. Fisk, Robert S. Abrams, John Ferguson, Jonathan R. Freedman, Robert J. Pangborn, Peter J. Sagona
  • Patent number: 8029562
    Abstract: Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: October 4, 2011
    Assignee: Medtronic, Inc.
    Inventors: Kathryn J. Kitching, Catherine E. Taylor
  • Publication number: 20110137263
    Abstract: A syringe stopper that is suitable for use in syringes without silicone oil or other liquid lubricants. The invention provides a low friction barrier between an elastomeric stopper material and a therapeutic in the syringe. The barrier may inhibit materials from leaching from the elastomer material or from extraction of compounds from medicants by the elastomer. A process is also described that allows for molding thin barrier layers while allowing adequate bonding with the elastomer.
    Type: Application
    Filed: October 29, 2010
    Publication date: June 9, 2011
    Inventors: Edgar G. Ashmead, Edward C. Gunzel, Michael P. Moritz
  • Patent number: 7923053
    Abstract: Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: April 12, 2011
    Inventors: Kathryn J. Kitching, Catherine E. Taylor
  • Publication number: 20110082430
    Abstract: In one aspect, a self-lubriating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.
    Type: Application
    Filed: October 1, 2010
    Publication date: April 7, 2011
    Inventors: Samuel D. Conzone, David M. Rusinko, Chandrashekar Raman
  • Publication number: 20100298738
    Abstract: Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.
    Type: Application
    Filed: May 12, 2010
    Publication date: November 25, 2010
    Inventors: John T. Felts, Thomas E. Fisk, Robert S. Abrams, John Ferguson, Jonathan R. Freedman, Robert J. Pangborn, Peter J. Sagona
  • Patent number: 7766882
    Abstract: A rubber-made syringe piston with a film laminated on it includes a plurality of annular ridges of different outer diameters formed continuously and integrally on a sliding surface of a liquid-contacting, leading end portion of the piston. The annular ridges may preferably be different by from 0.01 to 0.2 mm from one to another in outer diameter.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: August 3, 2010
    Assignee: Daikyo Seiko, Ltd.
    Inventors: Morihiro Sudo, Tsuyoshi Koshidaka
  • Publication number: 20100186740
    Abstract: Medical articles with coatings are disclosed herein, as well as methods and systems for depositing these coatings onto medical articles. Surfaces of such articles may be coated. The coating(s) may serve as lubricants for reducing stiction between such surfaces or between a coated surface and another surface.
    Type: Application
    Filed: October 23, 2009
    Publication date: July 29, 2010
    Applicant: GVD Corporation
    Inventors: Hilton G. Pryce Lewis, Neeta P. Bansal, Erik S. Handy
  • Patent number: 7648487
    Abstract: A syringe coated with a lubricant containing a silicone oil and a fine silica powder on the inner surface of the barrel of the syringe can be used for injection of a surface-active drug solution without oil droplet formation on the inner surface while preventing an increase of the gasket sliding friction.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: January 19, 2010
    Assignee: Nipro Corporation
    Inventors: Akira Ito, Yoshihisa Murai, Takeshi Nizuka, Shin-ich Kawamura, Dai Sutou
  • Publication number: 20080312607
    Abstract: The present invention relates to a device comprising a piston sliding in a body like, for example, a syringe.
    Type: Application
    Filed: May 12, 2006
    Publication date: December 18, 2008
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Yves A. Delmotte, Agneta Blom
  • Patent number: 7246551
    Abstract: A sample handling tool includes a body having at least one plunger associated with a channel and arranged for axial movement within the channel. A seal is provided in the channel and sealingly engaged with a contact surface. The contact surface may include a surface feature, such that when contact surface moves, the seal and surface feature come into at least partial contact with one another. The seal may include an elastomeric member, such as an O-ring or X-ring, and the contact surface may be formed from any suitable material, including ceramic. The surface feature may take on a variety of forms including any suitable texture, surface porosity or include one or more grooves, holes, recesses, indentations, bumps, protrusions, etc., or a combination thereof.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: July 24, 2007
    Assignee: Protedyne Corporation
    Inventors: Peter Massaro, Michael Paschetto
  • Patent number: 7186242
    Abstract: A medical syringe assembly includes a first opening and a second opening at opposite ends of a tubular barrel having an inner wall. The inner wall includes an inner surface. A stopper having an engagement surface is slidably received in the tubular barrel and includes a portion for engaging the surface of the inner wall of said tubular barrel. A lubricant is disposed over a limited area of at least one member of the inner wall of the tubular barrel and the engagement surface of said stopper, whereby a sufficient amount of the lubricant is available to provide adequate reduction of friction between the surface of the inner wall of the tubular barrel and the engagement surface of the stopper.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: March 6, 2007
    Assignee: Becton, Dickinson and Company
    Inventors: Sandor Gyure, Terry L. Sprieck, Duane L. Schmitt
  • Patent number: 7141042
    Abstract: A method for lubricating a sealing member in a drug delivery device includes the steps of washing and rinsing the sealing members in hot deionized water following by drying the sealing members. The dried sealing members are tumbled with polymeric silicone and then irradiated at a target dose between 2.5 and 4.0 Mrads. The irradiated sealing members are then utilized in a variety of drug delivery devices including syringes, pre-filed syringes, drug cartridges, and needleless injector ampules.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: November 28, 2006
    Assignee: Becton Dickinson and Company
    Inventor: Thea E. Lubrecht
  • Patent number: 7111848
    Abstract: A gasket is capable of providing an excellent slidabiity and holding its sealability without applying lubricant and a gasket that can prevent a resin film from being peeled off of a gasket body and prevent the generation of a molding defect such as pinholes. The gasket can be installed slidably in a outer tube of a syringe, including a gasket body and a resin film formed of a material lower in coefficient of friction than a material of the gasket body, which covers at least an outer periphery of the gasket body, in which when a surface roughness of the resin film on the outer tube side is defined as Ra1 and a surface roughness of the resin film on the gasket body side is defined as Ra2, a relationship of 1.5 Ra1?Ra2 is satisfied.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: September 26, 2006
    Assignees: Terumo Kabushiki Kaisha, Kokoku Intech Co., Ltd.
    Inventors: Kouichi Tachikawa, Hiroyuki Yunoki, Yutaka Kikuchi
  • Publication number: 20040122376
    Abstract: A medical syringe assembly includes a first opening and a second opening at opposite ends of a tubular barrel having an inner wall. The inner wall includes an inner surface. A stopper having an engagement surface is slidably received in the tubular barrel and includes a portion for engaging the surface of the inner wall of said tubular barrel. A lubricant is disposed over a limited area of at least one member of the inner wall of the tubular barrel and the engagement surface of said stopper, whereby a sufficient amount of the lubricant is available to provide adequate reduction of friction between the surface of the inner wall of the tubular barrel and the engagement surface of the stopper.
    Type: Application
    Filed: November 5, 2003
    Publication date: June 24, 2004
    Applicant: Becton, Dickinson and Company
    Inventors: Sandor Gyure, Terry L. Sprieck, Duane L. Schmitt
  • Patent number: 6749590
    Abstract: A syringe of improved ergonomics having an ellipsoidal barrel which contains an ellipsoidal plunger. The plunger consists of: a plunger tip of a rigid, non-elastomeric material which interfaces a medical fluid contained in the syringe barrel; and an elastomeric ring which slideably interfaces the inside wall of the syringe barrel. In one embodiment the plunger contains a plastic plunger insert which supports the elastomeric ring, the interior of which is provided with an ellipsoidal cavity. A self-aligning plunger rod having a ball portion on its distal end is inserted into the cavity of the plunger insert. The ball portion freely moves in the cavity and directs the external force exerted on the plunger rod in an axial direction.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: June 15, 2004
    Assignee: Bracco Diagnostics, Inc.
    Inventor: John J. Niedospial, Jr.
  • Patent number: 6746430
    Abstract: A method for lubricating a sealing member and a medicament chamber in a drug delivery device includes providing lubricating silicone on the surface of the stopper and within the plastic material of the chamber. The stopper preferably is first washed and rinsed in hot deionized water followed by drying. The dried sealing member is then tumbled with polymeric silicone and then irradiated at a target dose between 2.5 to 4.0 Mrads to cause the silicone molecules to bond with the elastomeric material of the stopper. The irradiated sealing members are then loaded in any of a series of chambers including syringes, pre-filled syringes, drug cartridges, and needleless injector ampules. The chamber preferably is made from a plastic material that has been mixed with a lubricating solution such as silicone when the plastic is compounded.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: June 8, 2004
    Assignee: Becton, Dickinson and Company
    Inventor: Thea E. Lubrecht
  • Patent number: 6663603
    Abstract: A medical syringe assembly includes a first opening and a second opening at opposite ends of a tubular barrel having an inner wall. The inner wall includes an inner surface. A stopper having an engagement surface is slidably received in the tubular barrel and includes a portion for engaging the surface of the inner wall of said tubular barrel. A lubricant is disposed over a limited area of at least one member of the inner wall of the tubular barrel and the engagement surface of said stopper, whereby a sufficient amount of the lubricant is available to provide adequate reduction of friction between the surface of the inner wall of the tubular barrel and the engagement surface of the stopper.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: December 16, 2003
    Assignee: Becton, Dickinson and Company
    Inventors: Sandor Gyure, Terry L. Sprieck, Duane L. Schmitt
  • Patent number: 6562010
    Abstract: A medical syringe assembly includes a first opening and a second opening at opposite ends of a tubular barrel having an inner wall. The inner wall includes an inner surface. A stopper having an engagement surface is slidably received in the tubular barrel and includes a portion for engaging the surface of the inner wall of said tubular barrel. A lubricant is disposed over a limited area of at least one member of the inner wall of the tubular barrel and the engagement surface of said stopper, whereby a sufficient amount of the lubricant is available to provide adequate reduction of friction between the surface of the inner wall of the tubular barrel and the engagement surface of the stopper.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: May 13, 2003
    Assignee: Becton, Dickinson and Company
    Inventors: Sandor Gyure, Terry L. Sprieck, Duane L. Schmitt