Abstract: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also includes a transfer device having a cannula with a first end and a second end. The first and second ends are adapted to puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers.

Abstract: Provided is a system for sampling and pretreating biological fluid. It comprises: a piercing unit having at a lower portion a capillary tip which is to be inserted into skin to a predetermined depth to take biological fluid therethrough; a dropper, connected to an upper portion of the piercing unit, having an injection tube at an upper portion thereof, the injection tube communicating with the capillary tip; and a reagent container, designed to accommodate the piercing unit therein in an airtight manner so as to seal an outer circumference of the piercing unit, functioning to contain a reagent for treating the biological fluid of the capillary tip of the piercing unit. The system allows even a novice to sample and pretreat biological fluid with high accuracy without the use of expensive precision devices. The system employs fewer expendable supplies, thus providing higher convenience for the user.

Abstract: A vial for storing multiple doses of a substance to be dispensed into one or more syringes or other delivery devices. The vial has a body, a variable-volume storage chamber within the body for storing multiple doses of the substance therein, and a one-way valve connectable in fluid communication with a syringe or other delivery device. The one-way valve is moveable relative to the body between first and second positions (i) one of which permits the valve to open so that substance from the variable-volume storage chamber can flow therethrough and into the syringe or other delivery device connected in fluid communication therewith, and (ii) one of which prevents the valve from opening.

Abstract: The present invention relates to a medical device connector for connecting a piercing device (3), with a vial (2) comprising a base member. A plurality of grip members (50), each grip member (50) comprising a distal end (D) and a proximal end (P) and each comprising a wedge portion (61) adapted to temporarily or permanently lock the medical device connector (1) to the vial (2). The base member (30) further comprises a plurality of flanges (40), wherein the proximal ends (P) of the grip members (50) are arranged to the flanges (41, 40). The flanges (40) extend substantially out from the periphery of the base member (30) in a direction substantially perpendicular to the direction of the grip members, wherein the space formed between the flanges (40) of the base member (30) forms at least one grip portion.

Abstract: The present invention relates to a first medical device (1, 100) configured to permit connection to a second medical device (3). The medical device (1, 100, 200) comprises a guiding track (12) for receiving a lock protrusion (4). The guiding track (12) comprises a surface (16) having a lock edge (15) extending between a first and a second level (H1, H2). The lock edge (15) extends in a smooth curvature between the first and the second level (H1, H2), the curvature of which is a function of at least of radius (Ra). The medical device (1, 100) may comprise a neck element (11) with at least one guiding track (12) for receiving a lock protrusion (4) of a second medical device (3) or optionally the medical device may comprise a sleeve member (202) which comprises the guiding track (12). The present invention provide for a connection site which enables a smooth lock but especially a smooth unlock motion of the second medical device being connected.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle.

Abstract: A needle safety guard device adapted to attach to a liquid container is provided. The device includes a disk-shaped shield having a medial opening connected with a radial opening between two radial edges. The device also includes a substantially U-shaped holder having two sidewalls coupled substantially perpendicular to the disk-shaped shield along the two radial edges, and a top cover connecting to the two sidewalls and extending from the shield above the radial opening. The U-shaped holder includes a wedged protrusion and a curved protrusion extending from each of the two sidewalls, the curved protrusion being between the top cover and the wedged protrusion for blocking a cap of the liquid container from moving toward the medial opening.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: A primary package for simultaneously dispensing microdoses of from 5 to 500 microliters of one medicament contained in a medicated module and another medicament contained in an attached injection system is disclosed, where the primary package contains a single dose of medicament contained within a reservoir cavity sealed with closure caps that secure top and bottom septa.

Abstract: In certain embodiments, a syringe mount of the invention may include a plate, an actuator, and one or more movable members located between the plate and the actuator. Each of the plate and the actuator may have an orifice defined therein, and an imaginary reference axis of the syringe mount may extend through one or both of these orifices. The actuator may be movable relative to the plate in a direction substantially perpendicular to the reference axis. Further, the moveable member(s) may be designed to move (e.g., pivot) toward the reference axis due to movement of the actuator from a first position to a second position and to move (e.g., pivot) away from the reference axis due to movement of the actuator from the second position to the first position.

Abstract: An apparatus for removal of premixed drugs or reconstitution of lyophilized drugs and for the injection of the reconstituted drug into the patient. The apparatus includes a syringe assembly and an adapter assembly that can be removably connected to a medicament container containing a premixed drug or lyophilized medicament. The syringe assembly of the apparatus includes a liquid chamber between the forward end of the body portion and the piston and a syringe cannula assembly. The syringe cannula assembly, which can be removably interconnected with the body portion, comprises a cannula support and a hypodermic needle sealably connected to the cannula support. The adapter assembly comprises an adapter preferably molded from a moldable plastic that includes a top wall, an adapter cannula connected to and extending from the top wall and a variety of connectors connected to the top wall for removably interconnecting the adapter with the medicament container.

Abstract: A drug injection apparatus includes a drug container, a needle tube having a first needle tip and a second needle tip, a needle-holding portion which holds the central portion of the needle tube, and a drug container mount from which the second needle tip projects. The drug container has a container body, having a contact portion to be penetrated by the second needle tip and a pressing portion that faces the contact portion, wherein the pressing portion is to be pressed toward the contact portion side so as to deform; a seal member attached to a portion of the contact portion to be penetrated by the second needle tip, and adapted to be brought into close contact with the circumferential surface of the needle tube in liquid-tight manner; and a protective plate adapted to avoid the pressing portion from being penetrated by second needle tip inserted into the container body.

Abstract: This disclosure relates to drug vial spikes, fluid line sets, and related systems. In some aspects, a fluid line set includes a frame, multiple spikes extending from the frame, and multiple fluid lines connected to the frame. The frame is configured to hold the fluid lines in a spaced apart configuration.

Abstract: A tube set insertion apparatus for connection to a bottle of saline solution, comprising a flange adapted to connect to the bottle at an opening in the bottle, a plurality of holding members positioned relative to one another to form a channel and to align a drip chamber disposed therein with the opening, each of the plurality of holding members connected to a corresponding one of a rack and a pinion, and a plurality of levers, each lever adapted to rotate about a corresponding pivot, and each lever connected to a corresponding other of the rack and the pinion. Each pinion positioned relative to a corresponding one of the racks such that rotation of the lever about its pivot causes a bottle, when disposed in the channel, to move toward the opening.

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

Abstract: A system for transferring solutions from a first cartridge into a second cartridge comprises a cartridge holder, a plunger driver, and a cartridge connector. The cartridge connector carries a transfer needle and an exhaust needle. The cartridge holder positions the first cartridge against the cartridge connector so that the transfer needle penetrates the first cartridge septum. The second cartridge is removably inserted into another end of the cartridge connector so that both the transfer needle and the exhaust needle penetrate the second cartridge septum. The plunger driver is disposed to advance a plunger on the first cartridge to transfer solution from the first cartridge into the second cartridge thus displacing solution from the second cartridge through the exhaust needle. The cartridge connector includes a sealed interior waste chamber for receiving the solution from the second cartridge.

Abstract: A vial enshrouded or contained in a protective covering which prevents emission of radiation form the vial contents, shielding the environment and personnel from irradiation. The vial optionally has a V-shaped bottom to allow withdrawal of a maximal amount of the fluid without inverting the vial. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends in to the V-shaped bottom. The vial access adapter may be vented or non-vented.

Abstract: In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. In some embodiments, an anti-reflux valve is positioned within the extractor channel. The anti-reflux valve can be configured to impede or obstruct fluid returning to a fluid source after withdrawal of the fluid from the fluid source.

Abstract: A closed fluid transfer system for fluidly interconnecting a syringe to any one of a patient I.V. set, a vial and an I.V. bag, is provided and includes a first adapter defining a lumen and supporting a seal across a first end of its lumen, the first adapter supporting a rear end of a needle within the lumen, wherein the seal is movable relative to the needle such that a tip of the needle penetrates through the seal; and a second adapter defining a lumen and supporting a seal across a first end of its lumen; wherein when the second adapter is coupled to the first adapter, the second adapter seal abuts the first adapter seal and moves the first adapter seal relative to the tip of the needle such that the tip of the needle penetrates through the abutting first adapter seal and second adapter seal.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: The present application is directed to devices. The device may used for connecting a closed receptacle and a container, such as a syringe.

Abstract: Some medicaments, such as botulinum toxin, are sold in small glass vials with a cap that comprises a seal. The seal is punctured to allow liquid to be added to reconstitute the medicament, then allow the medicament to be withdrawn through a needle into a syringe. A substantially larger amount of a liquid medicament may be obtained by using an adaptor device. An adaptor device may have a puncture component that allows a flexible tube to be inserted through the seal at an angle that allows an end of a flexible tube to rest on the bottom on a vial around the edge of the vial. This may allow vial to be tipped so that the liquid pools around the end of the flexible tube, thus significantly increasing the amount of liquid that can be withdrawn.

Abstract: The invention concerns a piercing member protection device, a kit of a piercing member protection device, a first and second fluid container and a method a method for transferring a fluid between a first and a second container using a piercing member protection device. The piercing member protection device comprises a protection chamber to protect at least the tip of a piercing member. The piercing member protection device further comprises a first and a second member arranged to each other.

Abstract: A flexible container for fluid administration is provided having a body defining a cavity, a base, and at least one port comprising a flange in contact with a flange of a terminal port having a punctureable membrane layer. The body has a cross-sectional configuration including a lower body section of a first dimension, a middle body section of a second dimension, and an upper body section of a third dimension, wherein the second dimension is smaller than the first dimension and the third dimension. The flexible container may also include a base having a plurality of creases that are foldable to form two folded ends each including an extension having a base of a first dimension and a tip of a second dimension.

Abstract: A connector system for medical fluid administration has a female connection member, which can act as an access port for a container of medical fluid, and a male connection member, for accessing the container of medical fluid. The female connection member defines a sheath for receiving a portion of the male connection member and this sheath is spanned at one end by a septum, which acts to close the container of medical fluid. A lumen is defined through the male connection member to allow passage of fluid therethrough. The septum has a central region and a peripheral region, the central region being of substantially greater thickness than the peripheral region. The male connection member comprises means for rupturing the peripheral region of the septum when it is received in the female connection member to form a connection.

Abstract: In one embodiment, a method of filling a container with a liquid drug from a drug reservoir may include: a) connecting a container and a drug reservoir with a cannula such that the drug reservoir and the container fluidically communicate with each other via the cannula, while being hermetically sealed; b) reducing a first volume contained within the container to displace a gaseous medium from the first volume of the container via the cannula into a second volume contained within the drug reservoir; c) increasing the first volume of the container to displace the liquid drug from the second volume of the drug reservoir into the first volume of the container to fill the container; and d) disconnecting the container and the drug reservoir. Before performing action d), action b) and action c) can be successively performed more than once to stepwise increase an amount of liquid drug displaced.

Abstract: An apparatus for assisting a user in loading a syringe with medication from a medicinal vial comprising an elongated guide having a syringe well and a vial well, the syringe well having a syringe well opening along a surface of the guide. A syringe guide member inserted into and removable from the syringe well through the syringe well opening, the syringe guide member having a bore for receiving and guiding the syringe. The vial well receiving the vial. The guide has a wall separating the syringe well and the vial well, the wall having an aperture formed therethrough providing communication between one end of the bore and the vial, the recess mutually adjacent with the wall. The guide includes a displaceable cover enclosing the syringe well and the vial well. The guide may also include a magnifying element coupled to the cover.

Abstract: Anti-vacuum-lock assemblies for preventing vacuum lock when withdrawing medicinal fluid from a vial comprising a multi-finger bung-type stopper in which the fingers are of sufficient length to protect a collapsing or expanding bladder in the vial from being punctured by the hypodermic needle. In a first embodiment the vial includes one or more side or bottom wall holes to permit ambient air to enter in the space between an internal bladder containing a medicinal fluid and the inner wall of the vial. In another embodiment, an expanding bladder in communication with the exterior expands as fluid is withdrawn from the vial. In a third embodiment a fluted collar is inserted in the vial neck to provide air passages into the space between the medicinal fluid-containing bladder and the interior wall of the vial. The collapse of the medicinal bladder or expansion of the compensation bellows or bladder prevents vacuum lock.

Abstract: A liquid-transfer adapter operatively interposable between an injector and a vial is provided. The adapter has an injector engaging portion configured for fluidly coupling to an injector and a vial coupling. The vial coupling includes a spike that has a spike axis and a tip portion configured for piercing a septum of a vial. The tip portion includes a plurality of facets that meet each other at one or more edges and at least one of the one or more edges is sloped with respect to the spike axis. The spike defines a channel extending therethrough in fluid communication with the injector engaging portion. A channel opening is defined in at least one of the facets and disposed without interrupting the edges.

Abstract: A method for removing a fluid medium from a container. The method comprises providing a removal device with a closed-off, sterilizable interior, with a needle element being held in the interior, the interior being closed off by a perforable sealing element; providing the container which contains the fluid medium, the container having a container wall with a perforable section; connecting the removal device and the container, the perforable section and the perforable sealing element being interconnected such that a protected region is created between the perforable section and the perforable sealing element, the protected region being closed off with respect to the surroundings in a substantially germ-free fashion as a result of the connection; and perforating the perforable sealing element and the perforable section by means of the needle element, the needle element penetrating the protected region.

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

Abstract: A system and method for intermixing the contents of two containers. The system includes a first container, a second container, and a connector for providing fluid communication between the first and second containers. The connector includes at least one resilient retention member for securing the first container to the connector. In addition, the connector accommodates standard vials containing, for example, medicaments, and prevents the unwanted discharge of the contents of the vial into the environment.

Abstract: Anti-vacuum-lock assemblies for preventing vacuum lock when withdrawing medicinal fluid from a vial comprising a multi-finger bung-type stopper in which the fingers are of sufficient length to protect a collapsing or expanding bladder in the vial from being punctured by the hypodermic needle. In a first embodiment the vial includes one or more side or bottom wall holes to permit ambient air to enter in the space between an internal bladder containing a medicinal fluid and the inner wall of the vial. In another embodiment, an expanding bladder in communication with the exterior expands as fluid is withdrawn from the vial. In a third embodiment a fluted collar is inserted in the vial neck to provide air passages into the space between the medicinal fluid-containing bladder and the interior wall of the vial. The collapse of the medicinal bladder or expansion of the compensation bellows or bladder prevents vacuum lock.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: The present invention relates to an insert for the infusion of drugs. The insert is suitable for connection to a vial and preferably to a circuit or an infusion line. Moreover the insert comprises a main body, a resilient element and a piercing spike. The piercing spike has an axis X and defines a first channel and a second channel and is movable relative to the main body along the axis X between a first closed position A and a second open position B. Moreover the resilient element presses against the piercing spike so as to keep it in the first closed position A when no external forces are applied.

Abstract: The invention relates to a device for removing a fluid from at least one container (300), from a vial for example, said container being closed by a closure (320) that can be punctured. The device comprises a base body (271) with a container receiving portion (272) and a hollow needle-like puncturing organ (277) in order to puncture the closure (320) of the container (300) in a removal position of the container (300). The aim of the invention is to enable mounting the container on the device without unintentionally puncturing the closure. This is achieved in that detent structures (274, 275) are provided which retain the container (300) on the device in a removal position and in a mounting position which is different from said removal position. Such a device can be used in particular to fill an applicator (280) with one or more fluid reservoirs from one or more vitals.

Abstract: A vial adapter includes a base having first and second opposing sides, a spike depending from the first side of the base, the spike having a spike passageway, and a connector disposed on the second side of the base, the connector having a connector passageway that is in fluid communication with the spike passageway. The vial adapter may be combined with a vial.

Abstract: The present invention provides devices and methods for mixing a formulation containing two or more constituents, such as a drug product and a diluent. The devices have a chamber for securing a container of the drug product. Various embodiments are presented. In one embodiment the device has two or more sides connected by a hinge, the two or more sides defining the chamber between them, and a handle for grasping and manipulating the device. In another embodiment the device has a housing with two or more side bars defining the chamber, the container being visible from outside the housing between the side bars and having a stopping element at the distal end, and a handle having two arms for grasping.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A package assembly for a drug reconstitution assembly includes a body, a drug reconstitution assembly and a removable lid. The body includes a plurality of protrusions configured to mate with a plurality of corresponding features of the drug reconstitution assembly to inhibit axial and rotational translation of the drug reconstitution assembly and its constituent parts during shipping and handling. By preventing axial and rotational shifting during shipment, premature and accidental puncture or contamination of the medication or the spikes within the drug reconstitution assembly is minimized.

Abstract: A female piercing member protection device for connection with a male connection part, and a method for connecting the device to a male connection part. The device includes an outer casing and a connection member at least partly enclosed in the outer casing. The outer casing is moveable between first and second positions. In the first position, the connection member is substantially locked from movement along the longitudinal axis A, and in the second position the connection member is able to move along the longitudinal axis A. The device also has an activated position and an inactivated position. When the outer casing is in the second position, a deformable locking device is prevented from deformation by the outer casing to prevent disengagement of the male connection part. A secure piercing member protection device significantly minimizes the risk for a user to be exposed to contaminants and the piercing member itself.

Abstract: A method for contamination-free transfer of liquid from one container to another, and devices to carry out the method are disclosed. Contamination-free transfer means that during the transfer process there is no (1) leakage of (a) the liquid, (b) air contaminated by the liquid, and (c) vapor from the liquid to the surroundings, and (2) surrounding contaminants from outside the containers that contact the liquid. The method's advantages include its simplicity, and the contamination-free transfer as defined above. The devices are adapted to effect contamination-free transfer of a hazardous drug to and from any container equipped with a standard connector port.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A filling system for syringes utilizing short needles to be filled from a vial having a thick septum is described. The system may be useful in any situation where the septum or vial stopper of a medication container is thicker than the usable length of the needle on the delivery device. Preferably, the syringe is filled just prior to use. The short needle includes an optional limiter which only permits a certain predetermined length of the needle cannula to protrude beyond the limiter a distance which limits penetration of the needle tip into both the skin and a vial stopper. The system and adapter may be useful for needles having a protrusion distance from approximately 0.5 mm to 3 mm, or any needle with a protrusion length shorter that the thickness of a septum to be accessed. Furthermore, a device is provided with shielding capabilities to shield the needle of the device.

Abstract: A system for removing or tranferring a pharmaceutical product from a reservoir including an ampoule with a moveable piston therein and an adaptor which includes, generally along a longitudinal axis, a reservoir connector and an ampoule connector for coupling to the ampoule, wherein the ampoule connector includes at least one locking mechanism which, in a side wall, includes a resilient element generally corresponding to a portion of the side wall which extends along the periphery thereof and, at opposing ends, merges with the side wall.

Abstract: The present invention is directed toward fluid transfer devices including a vial adapter having a top wall and a cannula with a cannula tip, and an elastic O-ring like sealing element sealingly encircling the cannula and initially disposed towards the cannula tip and spaced apart from the top wall, the sealing element being brought into initial contact with the vial stopper subsequent to the cannula tip contacting the vial stopper at a puncture site and thereafter being slidingly urged towards the top wall and continuously sealing the puncture site during snap fit mounting the vial adapter on the vial.

Abstract: A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle.

Abstract: A coupling device for transferring substances, in particular medical substances, is disclosed. The coupling device can be used for transferring medical substances between a patient and an infusion bag containing the medical substances. In one or more embodiments, the coupling device may include a piercing member for connection to a medical device such as the infusion bag. A piercing member for a coupling device is also disclosed.

Abstract: An object is to provide a communicating needle of simple construction which is attached to a medical infusion bag to connect two or more containers in fluid communication with each other. The communicating needle for connecting two or more containers to communicate includes a tip having an outlet opening formed thereon and a seal member integrally formed with the communicating needle to seal the outlet opening. The seal member readily comes off the communicating needle when acted upon by an external force, causing the outlet opening to open. The communicating needle may be covered by a seal body.