Abstract: Disclosed is a container and method for filling same. The container includes a thermally resealable portion that is fusible in response to thermal energy, and a container body having a sealed empty chamber in fluid communication with the resealable portion for receiving therein a substance. The container also includes a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. Each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion. The method of filling the container includes penetrating the resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member while engaging the base of the body to substantially prevent axial movement of the body, and applying thermal energy to the resealable portion to thermally fuse the penetrated region thereof.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: An ampoule including a casing, a facing side and a seal, wherein the casing has an outer diameter and the seal extends radially beyond the outer diameter and seals the facing side.

Abstract: The invention includes a device having a chamber within a syringe. A fluid passageway extends through a syringe piston. A valve is associated with the passageway controlling fluid passage through the piston. The invention includes a piercing structure having a head segment and a body portion, with a channel through the body portion and through at least one surface of the head without passing through the tip. In another aspect the invention encompasses a method of preparing an agent for administration to an individual. A first component is provided within a syringe and a second component is provided within a vial. A closed valve is associated with a fluid passageway between the vial and the syringe barrel through a piston. Valve repositioning allows fluid passage and sliding of the piston joins the first and second components. Repeated sliding of the piston mixes the components to produce the medication agent.

Abstract: Disclosed is a dispenser having a first chamber containing a first fluid and a second chamber containing a second material. Each chamber has screw threads that are selectively joinable so that the first and second chambers are twistable relative to one another. The first chamber includes an open top end that is, before use, covered with a breakable membrane. A breaker ring is located within the second chamber and is configured to break the breakable membrane when the dispenser is transitioned between an extended position and a compact position. In the compact position with the breakable membrane broken, the first fluid and second material form a mixture that can be dispensed via an opening in an openable tip.

Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.

Abstract: A needle assembly is disclosed, which includes a needle hub, a metal cannula and a plastic tip. The needle hub defines a fluid flow path therethrough. The metal cannula is supported on a distal end of the needle hub, where the metal cannula defines a fluid flow path into the distal end of the needle hub. The plastic tip member is connected to a distal end of the metal cannula, where the plastic tip member defines a fluid flow path into the distal end of the metal cannula. Plastic tip further includes a channel groove that runs along the length of the plastic tip to allow fluid to flow into a distal end of the metal cannula. Additionally, the plastic tip member is configured to pierce a septum of a vial.

Abstract: A fluid transfer device for transferring fluid from a first fluid container to a second fluid container such as a piercing member protection device is provided. The fluid transfer device can include a longitudinal axis and a first connection part having a connection means for connecting to a first fluid container. The fluid transfer device can further include a second connection part rotatably mounted to the first connection part by mounting means, and the second connection part can further include connection means for connecting a second fluid container. The mounting means can enable turning of the second connection part with respect to the first connection part. Such a device can allow a user to safely turn e.g., a syringe after assembly to read a volume indication or similar.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: An apparatus for removal of premixed drugs or reconstitution of lyophilized drugs and for the injection of the reconstituted drug into the patient. The apparatus includes a syringe assembly and an adapter assembly that can be removably connected to a medicament container containing a premixed drug or lyophilized medicament. The syringe assembly of the apparatus includes a liquid chamber between the forward end of the body portion and the piston and a syringe cannula assembly. The syringe cannula assembly, which can be removably interconnected with the body portion, comprises a cannula support and a hypodermic needle sealably connected to the cannula support. The adapter assembly comprises an adapter preferably molded from a moldable plastic that includes a top wall, an adapter cannula connected to and extending from the top wall and a variety of connectors connected to the top wall for removably interconnecting the adapter with the medicament container.

Abstract: A syringe guide may include a top portion adapted to receive a portion of a syringe, a medial portion extending downwardly from the top portion, and a bottom portion extending downwardly form the medial portion and adapted to receive a portion of a medication vial. The top portion may include top portion sidewalls and an end portion having an outer lip, the sidewalls defining a top portion having a semicircular shape. The medial portion may include medial portion sidewalls that extend substantially the length thereof and an upper portion including an upper lip having a semicircular shape. The medial portion sidewalls may include a passageway formed therethrough. The bottom portion may include a lower end, bottom portion sidewalls connected to and extending upwardly from the lower end, an upper end connected to the bottom portion sidewalls, and a locking mechanism adapted to receive and hold the medication vial.

Abstract: The present invention relates to a first medical device (1, 100) configured to permit connection to a second medical device (3). The medical device (1, 100, 200) comprises a guiding track (12) for receiving a lock protrusion (4). The guiding track (12) comprises a surface (16) having a lock edge (15) extending between a first and a second level (H1, H2). The lock edge (15) extends in a smooth curvature between the first and the second level (H1, H2), the curvature of which is a function of at least of radius (Ra). The medical device (1, 100) may comprise a neck element (11) with at least one guiding track (12) for receiving a lock protrusion (4) of a second medical device (3) or optionally the medical device may comprise a sleeve member (202) which comprises the guiding track (12). The present invention provide for a connection site which enables a smooth lock but especially a smooth unlock motion of the second medical device being connected.

Abstract: An access port for a medical fluid container is provided and in one embodiment includes a shell and a perforator located within the shell, the perforator including an end configured to pierce a medical fluid container. The access port also includes a safety cap, the safety cap initially preventing the perforator from rotating relative to the plane of the container or piercing the container film. The safety cap is manually removable to enable the perforator to pierce the medical fluid container. The shell includes a pair of hinged moving arms and members hinged to the arms. The members push the perforator towards the medical fluid container when the arms are pushed downwardly.

Abstract: The invention concerns a piercing member protection device, a kit of a piercing member protection device, a first and second fluid container and a method a method for transferring a fluid between a first and a second container using a piercing member protection device. The piercing member protection device comprises a protection chamber to protect at least the tip of a piercing member. The piercing member protection device further comprises a first and a second member arranged to each other.

Abstract: A connector assembly is provided with a first connector equipped with a first connector body, a hollow needle supported on the inner side of the first connector body and having a side hole (53), and a first sealing member having a head which can be pierced through by the hollow needle; a second connector equipped with a second connector body and also with a second scaling member which can, when in a mounted state, be pierced through by the hollow needle; and a close-contact maintaining means which can, when in the mounted state, maintain that the head and the second sealing member are in close contact with each other. When the second connector becomes pulled out of the first connector, the head and the second sealing member are held in close contact with each other by the close-contact maintaining means until the hollow needle is pulled out of the second scaling member.

Abstract: A fluid transfer assembly comprises means for connection to a syringe and means for receiving a vial having a closure element. The receiving means is adapted to engage and open the closure element and permit fluid in the vial to be transferred to the syringe from the vial, for example by gravity acting on the fluid in the vial.

Abstract: A spike for penetrating the elastomeric stopper of a container, for example a drug or reagent vial, is provided with an elongated body (5) with a blunt tip (47). The spike may be incorporated into a reagent cassette which accepts containers sealed with a punturable cap.

Abstract: Vacuum break vial assembly and method for reducing the incidence of nosocomial infections, comprising a vial stopper having an apertured needle sheath, and a hole in the bottom of the vial fitted with a single or multi-part bladder-retaining plug/vent assembly. The vial has an aluminum cap holding a plastic flip-off top, removal of which permits access by hypodermic needle through the stopper into the needle sheath. No pre-pressurization of the vial by ambient contaminated air via the hypodermic can occur. Rather, the needle is inserted in the vial through the stopper and the medicinal fluid withdrawn. Air is inlet via a vent into the collapsed bladder secured in the bottom of the vial and the bladder expands to permit withdrawal of fluid into the hypodermic without vacuum lock. No air having pathogen vectors is introduced into the vial medicinal fluid, as the bladder isolates volume-compensating air from the medicinal fluid.

Abstract: Methods for making an using convenience kits for hazardous drug (liquid) transfer from vials to syringes and target IV connectors. The following methods for making and using are disclosed: (1) Using a conventional plastic bag as a vial and vial adapter enclosing shroud. (2) Using of a flange (i.e. latch arm) free vial adapter which may, therefore, be used for a large variety of vial sizes. (3) Providing a seal about an access hole through which a vial adapter dispensing portion provides a closed fluid dispensing pathway. (4) Using the shrouding bag and an associated elastic band to provide desired stability of a spiked vial. (5) Accessing, measuring and transferring vial contents directly from a vial to a target IV container.

Abstract: A fluid ducting assembly for enabling flow communication between a syringe and either one of a vessel and a dispenser for dispensing a fluid contained, a priori in the syringe or in the vessel. The fluid ducting assembly includes a base having a first member, a second member, and a third member for connection to and providing flow communication with the syringe, the vessel and the dispenser, respectively. The fluid ducting assembly further includes a flow controller within the base enabling any one of a flow path between the first member and the second member and a flow path between the first member and the third member. The flow controller has either a first operative position in which the flow path between the first member and the second member in enabled or a second operative position in which the flow path between the first member and the third member is enabled.

Abstract: A withdrawal spike unit (200) comprises a withdrawal spike component (30?) and an integrally formed adapter component (60?) that is adapted to couple with a vial (10) in a safe and secure manner. The integral formation of the component parts (30?, 60?) makes fully automated manufacture and assembly of assemblies comprising such a withdrawal spike unit (200) coupled to a vial (10) possible. As such, human errors associated with the assembly at the point of use are mitigated.

Abstract: A fluid transfer device for use in an infusion system having a first end and a second end for coupling to an injection port of the infusion system. The device further includes at least a first member, a hollow needle attached to the first member, and a second member telescopically displaceable in relation to the first member, allowing the hollow needle to penetrate a flexible barrier member sealing the injection port thereby creating a fluid passage into the infusion system. The first end has a connecting portion for attachment to a drug bottle containing a fixed dose of a medical substance, and the second end has a flexible membrane able to be pressed against the flexible barrier member with a pressure sufficient to create a double-membrane sealing around the hollow needle.

Abstract: This disclosure relates to drug vial spikes, fluid line sets, and related systems. In some aspects, a fluid line set includes a frame, multiple spikes extending from the frame, and multiple fluid lines connected to the frame. The frame is configured to hold the fluid lines in a spaced apart configuration.

Abstract: This disclosure relates to drug delivery devices and related systems and methods. In some aspects, a drug delivery device includes a drug vial holder and a mechanism configured to compress a drug vial between upper and lower members of the drug vial holder.

Abstract: A drug storage and delivery device (1) comprising a reservoir (102) containing a liquid, a vial (101) containing a dry drug, such as a lyophilized drug, means (110) for forcing the liquid from the reservoir to the vial, via an established fluid connection, and valve means (106-108) to ensure a tight fluid connection between reservoir and vial can be established before the fluid paths are opened.

Abstract: A device and method for making an injection with a short needle, which includes a needle cannula and a limiter surrounding the needle cannula and includes a skin engaging surface on the limiter. The limiter is moveable from a first position in which an elongate portion of the needle cannula is exposed for access to a medication vial, to a locked second position in which the limiter is not movable from the second position to the first position. In the second position, the needle tip extends beyond the skin engaging surface a distance which is ordinarily unable to access the vial.

Abstract: Medical devices and methods for delivering therapeutic fluids transcutaneously to a body of a patient via a fluid delivery device and an adapter is provided. A Luer slip connector is provided at a first connecting end of the adapter. A therapeutic fluid container is connected with the second connecting end such that the container's neck is received in the second connecting end and a hollow penetrating member provided in the adapter punctures the septum of the container to admit the therapeutic fluid into a needle-less syringe from the container. After, fluid emerges from the tip of the penetrating member, the second connecting end of the adapter is attached to the fluid delivery device, thereby filling the reservoir with the fluid and pushing the syringe plunger forward to inject fluid into reservoir.

Abstract: The present invention concerns an attachable membrane device for providing a piercable liquid barrier membrane to the surface of a pierceable fluid container, such as an infusion bag. The attachable membrane device have a fastening part comprising a fastening surface adapted to be attached to the surface of the pierceable fluid container and thereby provide a liquid tight seal between the fastening surface and the surface of the pierceable fluid container. Additionally, the attachable membrane device is further provided with a barrier membrane part, adapted to provide a liquid tight seal after penetration by a piercing member. Connection means is arranged to the attachable membrane device. The invention simplifies the injection or withdrawal of a fluid in a pierceable fluid container.

Abstract: A vial enshrouded or contained in a protective covering which prevents emission of radiation form the vial contents, shielding the environment and personnel from irradiation. The vial optionally has a V-shaped bottom to allow withdrawal of a maximal amount of the fluid without inverting the vial. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends in to the V-shaped bottom. The vial access adapter may be vented or non-vented.

Abstract: The present invention relates to liquid drug medical devices for enabling the administration of liquid drugs, and also a needle shield removal device for safely removing needle shields.

Abstract: Vacuum break vial assembly and method for reducing the incidence of nosocomial infections, comprising a vial stopper having a 2-part withdrawn-fluid volume compensation assembly having a barbed vent element that secures an apertured needle sheath, a bladder-retainer tube and an expandable/unfoldable bladder. The vial has an aluminum cap holding a plastic flip-off top that removes a central portion of the cap to permit access by hypodermic needle through the stopper into the needle sheath. No pre-pressurization of the vial by ambient contaminated air via the hypodermic can occur. Rather, the needle is inserted in the vial through the stopper and the medicinal fluid withdrawn. Air is inlet into the separate bladder which expands to permit withdrawal of fluid into the hypodermic without vacuum lock. No air having pathogen vectors is introduced into the vial medicinal fluid as the bladder isolates volume-compensating air from the medicinal fluid. Plural embodiments are shown.

Abstract: Apparatus for use in a drug mixing system including a vial adapter assembly including a main body element having a vial receiving portion and a needle puncturable port, the main body element including an axial hollow tubular portion which is in fluid flow engagement with a bore of a vial puncturing spike, the main body element further including a membrane support surface that supports a first membrane which is in fluid flow engagement with the vial puncturing spike via the bore and via a recess formed in an intermediate portion of the main body element, and a second membrane supported by a membrane support member and separated by a gap from the first membrane.

Abstract: A blood chamber for an extracorporeal blood circuit comprises a blood inlet port (2), a blood containment chamber (3), a first conduit (8) which connects the blood inlet port (2) with the blood containment chamber (3) and which has an end tract (8a) that terminates in the blood containment chamber (3) with a horizontal inlet component. The first conduit (8) comprises a pre-terminal tract (8b) which precedes the end tract (8a) and which has at least a second horizontal component which is directed in an opposite direction to the horizontal inlet component. The blood chamber is used in an arterial line of a dialysis set for guaranteeing a regular and gentle blood flow.

Abstract: Cap adapters for a medicament vial configured to facilitate the transfer of liquid medicament from the vial and into a syringe. In one embodiment the cap adapter comprises a wall portion with a first lumen passing through it. A vial-engaging portion secures the cap adapter to the vial. A spike extends from the wall portion and defines a second lumen passing through the wall portion. A cone-shaped shield extends from the first lumen. The shield is configured to guide a hypodermic needle toward the first lumen to thereby reduce a risk of needlestick to a user handling the vial. In certain embodiments, a light source cooperates with the cap adapter to illuminate at least a portion of the cap adapter to reduce a risk of needlestick to a user handling the vial in a darkened environment. In certain embodiments, a secondary sealing member abuts a first face of the wall portion and seals an end of the first lumen.

Abstract: Cap adapters for a medicament vial configured to facilitate the transfer of liquid medicament from, the vial and into a syringe. In one embodiment the cap adapter comprises a wall portion with a first lumen passing through it. A vial-engaging portion secures the cap adapter to the vial. A spike extends from the wall portion and defines a second lumen passing through the wall portion. A cone-shaped shield extends from the first lumen. The shield is configured to guide a hypodermic needle toward the first lumen to thereby reduce a risk of needlestick to a user handling the vial. In certain embodiments, a light source cooperates with the cap adapter to illuminate at least a portion of the cap adapter to reduce a risk of needlestick to a user handling the vial in a darkened environment. In certain embodiments, a secondary sealing member abuts a first face of the wall portion and seals an end of the first lumen.

Abstract: A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial.

Abstract: A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial.

Abstract: A method and system for handling hazardous materials contained in a vial includes an isolation enclosure having an opening selectively sealable about the vial, a bag body portion, and a cap portion. A latching extraction element is attached to the cap portion and has a preceding engaging member to secure the vial to the isolation enclosure, an extraction member to be inserted into the vial and remove material therefrom, and a primary engaging member to secure the vial to the extraction member. A valve is mounted outside the isolation enclosure and controls the flow of fluid from the vial. An adaptor having a reseal member permits flow when coupled to the valve and restricts flow when uncoupled from the valve. Once uncoupled, the adaptor is removably associated with a second valve located remotely from the isolation enclosure, allowing fluid to pass into the second valve.

Abstract: A vial adapter element for use in a drug mixing system including a body, a vial connection port extending from the body, a hollow vial puncturing spike that protrudes into the vial connection port and is in fluid communication with a syringe-adapter-element connection port that extends from the body, and a plurality of resilient tongues spaced around an inner wall of the body, the tongues being located in gaps formed in the inner wall of the body.

Abstract: A device and method for mixing medical fluids is disclosed. The device has an inlet port, an injection port, an outlet port, a first duct between the injection port and the inlet port, and a second duct between the inlet port and the outlet port. The injection port is sealed by a fluid-proof membrane which can be penetrated by an injection needle. The device further includes at least a first portion made of a first material and a second portion made of a second, substantially more resilient material, wherein the inlet port and the injection port are included in the first portion and the outlet port is included in the second portion, and the first and second portions are attached to each other by means of a combined friction coupling and snap connection.

Abstract: A spike assembly having an elongate spike defining a hollow cannula that is in fluid communication with the interior of a luer connection portion. The spike assembly provides needleless access to a stopper of a vial to facilitate injection and withdrawal of fluids via a syringe barrel selectively secured to the luer connection portion. The syringe can safely be removed from the spike assembly and then be directly attached to a luer compatible connector. The elongate spike may include a frangible tip portion that can break away from the spike assembly within a vial. The spike assembly may have a neck with a pair of gripping wing members. The spike assembly may have a feature that prevents rotation of the spike in the vial stopper, thereby allowing the syringe to be easily and safely disconnected from the spike assembly without having to grasp the spike assembly.

Abstract: An assembly for transferring a fluid between a vessel having a body with an open end and a slidable piston positioned within the body and a vial having a penetrable seal. The assembly includes a housing having first and second open ends, and a bore extending between the first and second open ends. The housing is removably connectable to the piston. The assembly also includes a conduit having first and second ends and first and second apertures adjacent to the first and second ends, respectively. The present invention provides for an assembly for transferring a fluid between a vessel having a body with an open end and a slidable piston positioned within the body and a vial having a penetrable seal. The assembly includes a housing having first and second open ends, and a bore extending between the first and second open ends. The housing is removably connectable to the piston.

Abstract: The invention includes a device having a chamber within a syringe. A fluid passageway extends through a syringe piston. A valve is associated with the passageway controlling fluid passage through the piston. The invention includes a piercing structure having a head segment and a body portion, with a channel through the body portion and through at least one surface of the head without passing through the tip. In another aspect the invention encompasses a method of preparing an agent for administration to an individual. A first component is provided within a syringe and a second component is provided within a vial. A closed valve is associated with a fluid passageway between the vial and the syringe barrel through a piston. Valve repositioning allows fluid passage and sliding of the piston joins the first and second components. Repeated sliding of the piston mixes the components to produce the medication agent.

Abstract: The invention refers to a medical system comprising a first subsystem with a first connection portion (7), and a second subsystem with a second connection portion (12). The invention also refers to a device and a method for connecting the subsystems to each other. One of the subsystems contains a fluid. The connecting device is adapted to connect the subsystems to each other to permit transport of the fluid from one of the subsystems to the other subsystem. The device comprises a container (21) enclosing an inner space. A substantially sterile atmosphere is provided in the inner space. The container receives the first connection portion and the second connection portion in the inner space. A mechanism is provided for connecting, from outside the container, the first connection portion and the second connection portion to each other in the inner space.

Abstract: The invention comprises a novel apparatus for delivering a nutritive substance comprising a container body having a base at one end thereof, an upper portion adapted for removable receipt of a closure, the upper portion defining an opening therein, and a chamber defined by the container body, the chamber being in fluid communication with the upper portion opening. A laminate seal having at least two layers is bonded across the upper portion opening and is adapted to provide an airtight seal across the opening and prevent contact between said nutritive substance and the contents of said container until said seal is altered. The laminate seal comprises a first layer permanently bonded to a rim defining the opening in the container upper portion and a second layer that is releasably coupled to the first layer. A nutritive substance is bonded to the first layer of the laminate seal. The container additionally comprises a closure removably coupled to the upper portion.

Abstract: A device and method for easily filling a syringe with one hand is disclosed. The device includes a flat hand for holding a medicine bottle, a syringe holder with a curved finger for holding a syringe, a mounted post for securing the device and a swivel arm mounted to the post which holds the flat hand, wherein the swivel arm allows the user to invert the flat hand and the medicine bottle secured therein, and easily draw medicine from the medicine bottle into the syringe with one hand.

Abstract: The invention relates to an injection device, especially for a device for injecting an injectable product. Said device comprises a reservoir (12) for receiving the product, a first outlet arrangement (14) comprising a needle and used to transfer the product from the reservoir (12) to the injection site, and an actuating device (16) for applying a pressure (P) to the product in the reservoir (12), the actuating device (16) comprising a second, needleless outlet arrangement (44, 54) for transferring the product from the reservoir (12) to the injection site or being arranged against the second needleless outlet arrangement (46, 56) in a replaceable manner.

Abstract: A syringe adapter element for use in a drug mixing system including a housing element having a syringe port adapted for fluid connection with a syringe and a fluid port adapted for fluid connection with a fluid flow adapter element, a needle and at least one septum disposed in the housing element, the needle having a sealed orientation wherein the at least one septum blocks fluid flow through the needle and a fluid flow orientation wherein the needle punctures the at least one septum so as to permit fluid to flow through the needle, and an anti-separation device adjacent the fluid port, such that when the syringe adapter element is connected to a fluid flow adapter element, the anti-separation device applies a force that acts against separating the syringe adapter element from the fluid flow adapter element.

Abstract: The invention refers to a new system for packaging pharmaceutical compositions comprising active principles that may be administered intravenously, in particular it concerns a system for packaging in bottles which makes it possible to ensure the complete transfer of the content of the bottle into the liquid for intravenous infusion and at the same time prevent any accidental contact with the active principle by the health-care personnel preparing said intravenous infusion, and a complete kit for intravenous administration.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.