Abstract: Compositions, systems and methods utilizing engineered surgical irrigants providing delivery of components with therapeutic or other secondary benefits. Engineered irrigants provide targeted delivery of desired agents, including agents for propulsion of nano-devices, agents including molecular probes, gene expression agents, magnetically orientable agents, agents for discrete tissue temperature detection and tissue regeneration agents.

Abstract: A fluid injection device includes: a pulse generation section that includes a fluid chamber whose volume is changeable, and an inlet flow passage and an outlet flow passage that are connected to the fluid chamber; a first connection flow passage connected to the outlet flow passage, having an end portion; a second connection flow passage connected to the inlet flow passage; a fluid injection opening formed at the end portion of the first connection flow passage, having a diameter smaller than the diameter of the outlet flow passage; a connection flow passage tube including the first connection flow passage and having rigidity adequate to transmit pulses of fluid flowing from the fluid chamber to the fluid injection opening; and a pressure generation section that supplies fluid to the inlet flow passage.

Abstract: Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

Abstract: An apparatus and method to suppress vacuum surges in a surgical aspiration system is disclosed and claimed. A vacuum surge suppressor includes a first fluid path for coupling to a surgical instrument, and a filter attached to the first fluid path. A flow restrictor is coupled to the filter with the filter disposed upstream of the flow restrictor. The vacuum surge suppressor also includes a second fluid path for coupling to a vacuum pump. The second fluid path is connected to the flow restrictor and disposed downstream of the flow restrictor. The second fluid path defines a path internal pressure. A third fluid path is coupled to the filter and is connected to the second fluid path, bypassing the flow restrictor. A valve in the third fluid path obstructs flow in the third fluid path in response to the path internal pressure.

Abstract: A method and apparatus for performing modulated fluid delivery and aspiration during a surgical procedure such as phacoemulsification is provided. The method and apparatus include delivering fluid and/or aspirating fluid in a modulated or pulsed manner during a surgical procedure, including applying fluid and/or aspirating fluid in connection with ultrasonic energy at a level and for a time period sufficient to induce transient cavitation. Fluid may be applied and/or aspirated at a timing sequence and duty cycle similar to or different from application of ultrasonic energy delivery.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: A fluid injection device includes: a pulse generation section that includes a fluid chamber whose volume is changeable, and an inlet flow passage and an outlet flow passage that are connected to the fluid chamber; a first connection flow passage connected to the outlet flow passage, having an end portion; a second connection flow passage connected to the inlet flow passage; a fluid injection opening formed at the end portion of the first connection flow passage, having a diameter smaller than the diameter of the outlet flow passage; a connection flow passage tube including the first connection flow passage and having rigidity adequate to transmit pulses of fluid flowing from the fluid chamber to the fluid injection opening; and a pressure generation section that supplies fluid to the inlet flow passage.

Abstract: A pin for hygienic and/or medical use in the anal region includes a first section extending from a predetermined end of the pin in the longitudinal direction thereof, and a second section that is offset from the first section in the longitudinal direction of the pin. The first section is introduced into the anal region of a patient and the second section enables a user to hold the pin. The first section includes, on its surface, one or more receiving elements, by way of which stool remainders can be removed from the anal region and/or substances can be supplied to the anal region.

Abstract: Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.

Abstract: A medical pump that provides advance guidance to a user regarding existence and limits of a valid input range for a pump programming parameter includes an input device for entering a value of a pump programming parameter, a memory for storing constraints related to the pump programming parameter, and a processor in communication with the memory and the input device. The processor dynamically utilizes the constraints to determine and generate a signal indicating whether a valid input range exists for a to-be-entered value of the pump programming parameter and notifies the user.

Abstract: An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.

Abstract: A system for collecting and disposing of liquid medical waste includes a fluid collection cart and a draining and cleaning station. The fluid collection cart includes a pair of containers, each of which includes a draining port and a cap. Each cap includes an outer portion having a flushing port and a bore formed therein and an inner portion having vacuum and patient ports formed therein. The inner cap portion is disposable and removably positioned within the bore of the outer cap portion. Liquid level detectors also communicate with each container. The cart also includes a regulator so a low vacuum level may be pulled on one of the containers while a full vacuum level is pulled on the other container. Fluids are collected in the containers via suction tubes connected to the patient ports. The flushing and drain ports of the containers are connected to corresponding flushing and drain connectors on the station when the containers are full so that they may be drained and flushed.

Abstract: This invention relates to sterilized cyanoacrylate adhesive compositions with x-ray imagining capabilities, methods of making such compositions, and methods of using such compositions.

Abstract: Provided is a surgical instrument which can provide a field of view over a surgical site by sucking blood from a bleeding site during surgery such as tissue dissection and illuminating a dark and deep surgical site. The surgical instrument includes a first body including at least one suction port provided at a front end thereof, a second body configured to cross the first body and to be rotatably coupled to the first body, a suction unit provided in the first body to suck blood from a bleeding site of a patient through the suction port during surgery, and an illuminator provided in the second body to illuminate a space between front ends of the first and second bodies.

Abstract: An infusion system comprises a disposable wearable infusion device having a body arranged to be adhered to a patient's skin and a reservoir for holding a liquid medicament to be infused into the patient. The infusion system further comprises a filler device arranged to be detachably received by the infusion device and to provide a positive pressure directly to the liquid medicament to transfer a volume of the liquid medicament to the infusion device reservoir.

Abstract: An embodiment of the present invention relates to a device, which can be implanted into a patient, for an in vivo measurement. In an embodiment, the device includes a catheter for guiding a sample of the patient town analysis unit in the device. A measurement result is determined in the analysis unit by analyzing the sample with the aid of a reagent. In an embodiment, the device furthermore includes an interchange chamber, with the aid of which the reagent can be removed from the device or can be inserted into the device. The interchange chamber has a connector allowing removal or insertion of the reagent while the device is implanted.

Abstract: Apparatuses and methods for administering a hemostatic agent to the tissue surrounding an opening in a body lumen are disclosed. The apparatus can include a tissue-contacting region and an optional body lumen-penetrating region. At least one hemostatic agent is included as a component of a coating over and/or a mixture with the material of at least a portion of the tissue-contacting region.

Abstract: A process comprises the phases of: activating a pusher, which exerts a push force on a plunger of a syringe containing the infusion liquid; measuring the push force by means of a load cell; comparing the push force with a maximum threshold; halting the pusher when the maximum threshold is exceeded; after a predetermined pause, restarting the pusher and emitting a consent signal indicating correct loading of the syringe if, within a certain time from the restart, the push force again exceeds the maximum threshold. The infusion device serves to inject an anticoagulant into an extracorporeal blood circuit. The control process guarantees against loss of infusion due to an incorrect initial loading of the syringe.

Abstract: Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

Abstract: One embodiment having features of the invention is directed to a guide block for an MRI device which has a block body with a proximal face, a distal face, and four parallel passageways extending between the two faces. The first passageway is centrally disposed, the second passageway is disposed vertical or horizontal to the first, the third passageway is located diagonal to the first and has a longitudinal opening in fluid communication with the first passageway, and the fourth passageway is diagonal to the first and in an opposite side of the body from the third passageway. In an alternative embodiment the guide block has at least one passageway that is not parallel to the longitudinal axis.

Abstract: One embodiment having features of the invention is directed to a guide block for an MRI device which has a block body with a proximal face, a distal face, and four parallel passageways extending between the two faces. The first passageway is centrally disposed, the second passageway is disposed vertical or horizontal to the first, the third passageway is located diagonal to the first and has a longitudinal opening in fluid communication with the first passageway, and the fourth passageway is diagonal to the first and in an opposite side of the body from the third passageway. In an alternative embodiment the guide block has at least one passageway that is not parallel to the longitudinal axis.

Abstract: The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.

Abstract: An apparatus for connecting a respiratory device with a patient is provided, including a breathing tube for insertion into a patient's trachea, an inflatable cuff positioned around the breathing tube, a connection tube connected to the cuff for providing inflating air flow thereto, a pressurized air reservoir, and a valve connected to the pressurized air reservoir and to the proximal end of the connection line. The valve includes an entry port associated with an entry differential force chamber, a first exit port associated with a first differential force chamber and coupled with the connection line, a second exit port associated with a second differential force chamber and coupled with the pressurized air reservoir, and a flexible membrane selectively sealingly separating the differential force chambers. The flexible membrane is configured to selectively connect the first and second differential force chambers to maintain a substantially constant air pressure in the cuff.

Abstract: The invention discloses a novel uterine stimulant, which is in the form of the stick. The uterine stimulation stick, on administration, helps a woman's uterus to contract, or to increase the frequency and intensity of the contractions. Such medicine can be suitably used to induce (start) or augment (speed) labor; facilitate uterine contractions following a miscarriage; induce abortion; or reduce hemorrhage following childbirth or abortion. The proposed medicine produces normal result for desired purpose, without any significant side effect for the mother or fetus.

Abstract: A device for measuring a flow rate of Ringer's solution includes a key input unit including a number input key through which a user can make an input each time when a drip drips in a drip chamber; a power supply unit for supplying power; an oscillation circuit for oscillating a signal having a preset frequency; a display unit for quantitatively outputting a calculated flow rate of Ringer's solution; and a control unit for calculating an elapsed time when the input is made through the number input key of the key input unit for a preset number of times, calculating the number of drips per an hour using the preset number of times and the calculated elapsed time, acquiring a quantitative flow rate of Ringer's solution by multiplying a preset volume of each drip and the calculated number of drips, and outputting the acquired flow rate to the display unit.

Abstract: A spinal platform for delivering a therapeutic agent to a spinal cord target includes a brace member for attachment to a plurality of bony structures surrounding at least a portion of the spinal cord target, a carriage member operatively coupled to and movable along the brace member, and a universal joint for adjusting the coronal or sagittal angle of a surgical instrument. The brace member includes at least one longitudinal rail and a plurality of attachment members. The plurality of attachment members is operably connected to the at least one longitudinal rail. The at least one longitudinal rail includes a proximal end portion, a distal end portion, and a middle portion extending between the proximal and distal end portions. The universal joint is seated within a portion of the carriage member and is capable of delivering the therapeutic agent to the spinal cord target.

Abstract: An improved method and apparatus for anchoring bone screws into bones of living beings includes a cannulated screw or bone anchor that is provided with at least one discharge opening in the distal end thereof. The head of the screw is configured to receive therein a material delivery probe in sealing relationship therewith. A fluid insertion device is connected to the material delivery probe and pumps a highly viscous material through the material delivery probe and into the interior of a bone in which the distal end of the screw has been inserted. The screw can be anchored proximally in bone to prevent backpressure from dislodging the delivery cannula and aides in achieving the high pressures necessary to cause the positive effects of materials previously not injectable in the bone or surrounding areas with the current methods and apparatia.

Abstract: The invention allows an increase in scope of application of a surgical device wherein the operational handpiece is embodied in the form of two parts, one of which includes a handpiece with an injection cannula and the other being a complementary part. The complementary part includes a stabilization handle and can be placed onto the injection cannula in addition to being able to be fixed to the handpiece of the operational handpiece.

Abstract: A one dose at a time, non-pressurised fluid dispensing canister from which the or each dose is dispensed as a result of two surfaces (21, 22) of the canister moving towards one another under the control of the user,—characterised in that the canister incorporates a mechanism which, once a first dose has been dispensed, automatically prevents any further dispensing movement of the said surfaces (21, 22) (in the case where the canister is a one-dosage only canister) or (where the canister is a multiple-dosage-dispensing canister) allows such movement only after the two surfaces (21, 22) have first been moved in a direction or directions other than that which alone caused the first dose to be dispensed.

Abstract: Disclosed is a receptacle for use with a medical suction device which is equipped with a cover body and an external case for detachably holding and air-tightly surrounding the receptacle and a patient-side tube for introducing waste liquid into the receptacle, and designed to create a negative pressure in both an interior space of the cover body and the external case and an interior space of the receptacle so as to allow waste liquid to be sucked into the receptacle through the patient-side tube. The receptacle has an air-pervious/liquid-impervious element having air perviousness and liquid imperviousness. The air-pervious/liquid-impervious element at least partly constitutes a portion of the receptacle to be surrounded by the cover body and the external case.

Abstract: A subpalpebral lavage catheter device for a mammal comprising a subpalpebral catheter having a first and a second end wherein the first end is located under the skin of the mammal and the second end further comprises an injection port, a hollow pouch, wherein the pouch has an opening adapted to receive the injection port of the catheter, a means for closing the opening of said pouch, and a plurality of loops attached to a side of the pouch, spaced apart and of a length wherein the loops are adapted to be braided into hair of the mammal.

Abstract: The present invention describes physiological sensors embodiment having a pressure ring around the sensors. The pressure ring embodiment is compressible and stretchable and non shearable. One or more electrode sensors embodiments are integrated to a stretchable strap that can be worn by a person on the torso. This system is capable of monitoring and measuring physiological information of the wearer more accurately and reliably and providing a comfortable to wear platform at the same time. Further the sensors in the embodiment can be replaced by actuators and used as an actuator embodiment with lesser motion artifacts.

Abstract: A waste collection and disposal system for use in health care facilities is provided. The system includes a mobile waste collection unit for moving between use areas in the health care facility to collect waste material generated during medical procedures including body fluids, body tissues, saline, etc. The waste collection unit includes stacked upper and lower waste containers for receiving the waste material. During use, the upper waste container can be emptied into the lower waste container for temporary storage. In addition, different vacuum levels can be provided in the waste containers during complex procedures. Once a user desires to empty the waste collection unit, the waste collection unit is wheeled to a docking station. At the docking station, the waste material is off-loaded to a waste drain and the waste collection unit is cleaned and rinsed for further use.

Abstract: Methods and devices are disclosed to reduce the tissue trauma that occurs when a physician retracts or otherwise deforms a patient's tissues for surgery or other medical procedures. In one part, methods and devices are disclosed for cooling the tissue around the incision. In another part, methods and devices are disclosed that elute drugs into the tissues of the tissue margin. In another part, methods and devices are disclosed to engage tissues during retraction to cushion, to sense tissue state, and to modulate tissue state.

Abstract: A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardium and deployment instruments and associated components for deploying the inserts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or non-resorbable. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enable blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used.

Abstract: The invention provides a device for Encapsulated Cell Therapy. The device includes an implantable capsule containing cells which secrete a biologically active compound for providing a biological function. The capsule has a semi permeable outer membrane for delivery of the compound e.g. at a site in the central nervous system or the spinal cord, e.g. In the brain of a patient. The capsule is connected to a tether which e.g. facilitates removal of the capsule from the patient. To facilitate insertion of the capsule into the patient, a stiffener may be attached to the tether to make the tether more rigid. The invention further provides a container for storing a cell therapy device and a method of locating the device in the body of a patient.

Abstract: A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand-held computer. Electronics determine the amount of glucose present in a sample of body fluid, when the test strip is positioned in the receptacle and the body fluid is placed on a test strip, and communicate the glucose amount to the hand-held computer via the connector portion.

Abstract: Methods and systems tell patients when to take their medications, control medication dispensing based on compliance to the prescribed dosage, and determine that the proper dosage has been taken. This system integrates with other devices related to home telehealth by including support for a world-wide web-based medical record associating the patient, his/her medication requirements or prescription, compliance with that prescription, and other associated medical telemetry data that may be used to determine patient response to said medication.

Abstract: The mouth moisturizing device for treatment of an individual suffering from xerostomia comprises a mouth moisturizing guard, including an attaching strap to be fit around the head holding the moisture guard gently over the mouth while sleeping.

Abstract: A device and method for delivering a pharmaceutical composition. The device includes an electronically controllable jetting device in communication with a source of a pharmacologically active material and a solid or fluidic mixing medium for receiving the ejected pharmacologically active material and directing it toward an end use destination.

Abstract: A system for recommending insulin bolus quantities to an insulin user includes a display unit and memory unit coupled to a control circuit with a user blood glucose target stored in the memory unit. The control circuit is programmed to receive the user's current blood glucose value, to determine and display via the display unit a recommended correction insulin bolus quantity if the current blood glucose value exceeds the blood glucose target, to compute a difference value as the current blood glucose value less the blood glucose target, and to produce a modified blood glucose target as a sum of the blood glucose target and the difference value for a lock-out time period if the difference value is positive. Additional correction insulin bolus quantities may be recommended during the lock-out time period if the user's current blood glucose value exceeds the modified blood glucose target.

Abstract: A device for delivering an allograft patch through a cannula provides for feeding of the device and the allograft patch through the cannula and provides for deploying of the allograft patch after feeding through the cannula.

Abstract: An apparatus for providing multiple vaccinations of poultry simultaneously is described. A neck injection, breast injection, two wing injections, and an eye mist or drop may be performed in one operation. The apparatus holds the bird in position for precise location of injections, thereby reducing wasted vaccine. The risk of injury to the bird during the process is minimized by greatly reducing the manual handling of the bird during vaccination. Vaccination costs are also reduced by the reduction of labor otherwise required in this process.

Abstract: Various embodiments of the present invention concern improving the dosing accuracy and efficacy of systems that calculate medicine doses for injection in animals and prepare the correct dose in an automated syringe subsystem. In an embodiment, the improvement is gained by simultaneously protecting the medicine from ambient outdoor temperatures that thermally degrade its efficacy while precisely monitoring the amount of medicine remaining inside the source vial to prevent inadvertent under-dosing due to undetected source depletion. This dual-sleeve system (one for temperature, one for data storage concerning the source vial contents) forms an intelligent adjunct to current and future automated injection technology used to maintain healthy livestock.

Abstract: A process is provided for sterilizing brachytherapy devices with Ethylene Oxide gas and releasing the devices on a parametric release basis. Devices that can be sterilized with this process include interstitial radiation seed strand implants and the needles used for implantation. In order to be sterilized effectively by EtO gas, the devices are constructed such that surfaces not readily infused with EtO gas are made to be gas permeable, and will not retain the gas after the sterilization process. Performance qualification of the sterilization process is performed through physical and microbiological studies, and set of established physical process parameters. Maintaining the physical process parameters in subsequent sterilization cycles will consistently yield the desired sterility assurance level without having to test the devices for sterility.

Abstract: The present disclosure relates to sleeves that are configured to facilitate release of nitric oxide.

Abstract: Ultrasonic devices for preventing microbubbles and/or microparticles from reaching the brain during a PCI or cardiovascular surgery. Devices 27 and 77 are designed for implantation in the chest cavity and operate in combination with needle vents or other vent systems for removing diverted microbubbles. Systems 77 and 83 are designed for noninvasive employment. Devices 57 and 87 are particularly designed to prevent microbubbles from reaching the great origins of the carotid arteries and/or for diverting bubbles that might reach the vicinity and otherwise pass through. Improved devices 11 and 94 separate microbubbles from a flowing bloodstream and produce a cleansed stream.

Abstract: Disclosed is a medical infusion device, such as an externally worn insulin pump, capable of being in remote communication with a controller or data acquisition unit such as a blood glucose meter. The disclosed medical infusion device includes a dual frequency antenna to facilitate communication with the remote device and the antenna is mounted using a spring-design that inhibits transmission of vibration to the antenna.

Abstract: An infusion device comprises a pusher for a plunger of a syringe containing a liquid to be infused. A load cell measures the push force. An encoder associated to a motor commanding the pusher measures the displacement of the pusher. A controller signals an alarm when the ratio between the variation of the push force and the displacement exceeds a predetermined threshold. The device, which serves for infusing an anticoagulant into an extracorporeal blood circuit in a dialysis apparatus, is able to signal an onset of an anomalous situation of lack of infusion in good time.

Abstract: Onions (Allium Cepa and its close relatives, as opposed to Allium Sativum) contain potent coagulation modulators, as well as platelet inhibitors. Clinical, in vivo and in vitro testing confirms that the efficacy of commonly consumed quantities of onions in terms of the efficacy of its impact on coagulation and platelet function rivals and in many respects exceeds the potency of any other modalities available today. Additionally, onion compounds have unique effects as described later in this application.