Abstract: The present disclosure relates to a monitoring unit for a medicament delivery device, where the monitoring unit has a monitoring circuit arranged in the housing that is capable of detecting and monitoring functions of the medicament delivery device. The monitoring device also has an attachment mechanism provided arranged with releasable locking elements, a mechanical interface arranged to interact with a mating mechanical interface arranged on a medicament delivery device, and an activation switch arranged to activate said monitoring circuit.

Abstract: An apparatus for implanting electrodes in neural tissue to connect a neural modulator to the tissue to send and receive signals from the neural tissue and a method for implanting the electrodes.

Abstract: A method and apparatus are provided for use in locating a target region which is situated in the body of a subject, for example for the delivery of drugs. The system includes an assembly for controlling the flow of fluid from a fluid reservoir to a conduit, such as a needle. A sensor detects a characteristic indicative of the fluid pressure in the conduit. The system processes data from the sensor to detect the presence of a pulsatile waveform. A controller may control further operation of the system based on information regarding the presence of the pulsatile waveform and features of the waveform, such as amplitude.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves determining a current value for a physiological condition of the user influenced by the fluid violates a first threshold value, determining a predicted value for the physiological condition of the user violates a second threshold value, and automatically altering operation of the infusion device to modify delivery of the fluid to the user after determining the predicted value violates the second threshold value when the current value violates the first threshold value.

Abstract: Ambulatory infusion pumps, durable assemblies, and disposable assemblies, including energy sources, reservoirs, baseplates, and related components therefor, as well as component combinations and related methods.

Abstract: A system for measuring an amount of liquid in an elastic bag, where there is formed in the lower area of the elastic bag a liquid opening for retrieving liquid from the elastic bag. The system includes push elements, which abut at opposite walls of the elastic bag and which are spaced apart from one another, a drive unit, which is configured to drive at least one push element, sensors, and a control unit. The sensors are configured to measure a liquid level of the liquid in the elastic bag. The control unit is configured to calculate an amount of liquid in the elastic bag on the basis of the liquid level and the distance between the push elements. The liquid level of the liquid in the elastic bag is changeable by reducing the distance between the push elements by means of the at least one drive unit.

Abstract: A control unit for an electronically controlled pump unit controls the pump unit to infuse insulin into a diabetic's body in a substantially continuous way according to a preset infusion schedule as a function of time. The control unit includes an intervention unit that continuously evaluates a blood-glucose indicative input for detecting an actual or expected hypoglycaemia and executes, in response to an actual or expected hypoglycaemia, a temporary hypoglycaemia intervention. The intervention includes, for an intervention time interval, overriding the preset infusion schedule by temporarily suspending insulin infusion or temporarily reducing insulin infusion below the preset infusion schedule. The intervention unit adapts its way of operation with respect to executing the hypoglycaemia intervention in accordance with a control signal that is separate from the blood-glucose indicative input. The control unit automatically generates the control signal as a function of time and/or based on sensor input.

Abstract: Methods, computers, and systems used to improve accuracy of analyte level measurement of an in vivo positioned analyte sensor are disclosed herein. The methods, computers, and systems disclosed herein may be used to provide a calibrated analyte level. Specific embodiments relate to methods, computers, and systems for improving accuracy of glucose measurement of an in vivo positioned glucose sensor.

Abstract: A system and method for calibrating an IV pump infusion system tube comprises a fluid source, an infusion system comprising, an IV pump, a drive unit, a chamber with known constant volume, a control unit, and IV tubing with a known inner diameter tolerance, and a sensor and floating detection object. The system administers medicinal fluid, calculates the flow rate of the medicinal fluid in the chamber by measuring the time the floating detection object and medicinal fluid rises in the chamber, compares the calculated flow rate with a set flow rate of the IV pump input in the control unit prior to infusion, and adjusts the IV pump and flow rate based on the compared deviations for more accurate delivery to a patient. This configuration may provide a more precise delivery rate of medicinal fluid, preventing harm to the patient and waste of medicine.

Abstract: A drug injection system includes a cartridge adapter and a drug injection device. The cartridge adapter includes: a main body case; an attachment portion provided on the main body case used for attachment to the drug injection device; an accommodating portion that accommodates therein a drug cartridge; a piston; a piston gear that allows the piston to slide therethrough; a stopper that stops movement of the piston gear; and a release lever that releases a locked state of the piston gear. The drug injection device includes: a casing that accommodates therein a portion of the cartridge adapter; an engagement portion that engages with the cartridge adapter; a drive gear to which the piston gear of the cartridge adapter is connected; a motor connected to the drive gear; and a release bar that drives the release lever of the cartridge adapter.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: A medication safety device and method can include an infusion pump and a drug library in communication with the infusion pump. The drug library can have upper hard and soft limits and lower hard and soft limits associated with at least one drug. A graphical user interface can display a bar chart showing upper and lower soft limit bars for the at least one drug. The upper and lower soft limit bars can be grabbed and dragged on the graphical user interface in touch-screen fashion to new positions associated with new upper and lower soft limits. The graphical user interface and associated hardware and software can be configurable to responsively re-analyze data and compare a particular infusion to the new upper and lower soft limits.

Abstract: Methods and apparatus for wireless power transfer and communications are provided. In one embodiment, a wireless power transfer system comprises a transmit resonator configured to transmit wireless power, a receive resonator configured to receive the transmitted wireless power from the transmit resonator, a medical device configured to receive power from the receive resonator, a controller configured to change an operating parameter of the medical device resulting in a change to a sonic signature of the medical device, and a listening device configured to determine an intended communication from the implanted medical device or the implanted receive resonator based on the change to the sonic signature coming from the implanted medical device.

Abstract: An infusion pump is provided, including a specially programmed microprocessor, a flow sensor for measuring flow from a source of fluid through an output tubing, a pumping section including a plurality of fingers in operational relationship to the output tubing, an outlet valve associated with the output tubing, and a first actuator configured for sequentially displacing the plurality of fingers to displace fluid through the output tubing. An inlet valve is disposed between the pumping section and the source of fluid; and a second actuator is also included. For detection, by the flow sensor, of flow above a predetermined level, the microprocessor is configured for one of: closing the outlet valve independently of the inlet valve using the first actuator; and closing the inlet valve independently of the outlet valve using the second actuator.

Abstract: The present invention provides a device (1) for monitoring the application of a drug to a patient by means of a drug pen (100), whereby the drug pen comprises a front end provided with an injection needle and a rear end provided with an actuation pushbutton, the device comprising a body (2) which can be dismountably coupled to the pen; an injection detection means determining when a drug injection is carried out; and a processing means configured for storing the date and time of the injection when the injection detection means detects that a drug injection is carried out, whereby the body is configured to be coupled to the pushbutton of the pen such that the pushbutton is actuated by pushing directly on the body, whereby the injection detection means is implemented as actuation detector configured for detecting said pushing action.

Abstract: A medical pump, in particular an infusion pump for conveying a medium, includes a seating for a hose clamp which is separate from the pump and arranged on the hose. Two clamping portions of the hose clamp which can be moved relative to each other can be transferred into a closed relative position in which they pinch off the hose arranged therebetween in such a manner that it is not possible for any medium to flow through the interior of the hose. Moreover, the clamping portions can be moved with respect to each other into an opened relative position in which the hose arranged between the clamping portions is not pinched off, so that the medium is able to flow through the interior of the hose. The pump is distinguished in that a sensor is provided thereon, in particular in the seating for the hose clamp, which sensor detects at least when the hose clamp is received in the seating—whether their clamping portions are in the closed or opened relative position.

Abstract: An infusion pump is provided, including a specially programmed microprocessor, a flow sensor for measuring flow from a source of fluid through an output tubing, a pumping section including a plurality of fingers in operational relationship to the output tubing, an outlet valve associated with the output tubing, and a first actuator configured for sequentially displacing the plurality of fingers to displace fluid through the output tubing. An inlet valve is disposed between the pumping section and the source of fluid; and a second actuator is also included. For detection, by the flow sensor, of flow above a predetermined level, the microprocessor is configured for one of: closing the outlet valve independently of the inlet valve using the first actuator; and closing the inlet valve independently of the outlet valve using the second actuator.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: Systems and methods for delivering a drug with a tracer or contrast agent are disclosed herein, as are systems and methods that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

Abstract: A system and method provide for enhanced reliability and safety of programming and/or operating a medical device, such as an infusion pump, with a remote control device, such as a mobile phone (e.g., a smartphone) can determine whether the smartphone is compatible with the medical device by checking the type and version of the smartphone as well as the versions of the operating software and/or firmware resident on the phone.

Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

Abstract: A medical device comprising an infusion device comprising a fluid reservoir to contain a therapeutic fluid and a transcutaneous access tool fluidly coupled to the fluid reservoir, the transcutaneous access tool configured to deliver the therapeutic fluid subcutaneously to a patient; wherein the infusion device operates in a stand-by mode prior to the therapeutic fluid being introduced into the fluid reservoir; wherein the infusion device operates to deploy the transcutaneous access tool within a predetermined deployment time period upon filling the fluid reservoir to a predetermined fill level with the therapeutic fluid.

Abstract: A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements.

Abstract: A system for sensing empty soft drink syrup containers in a soda pop dispensing arrangement is provided that includes at least one soft drink syrup container; a mixing station for mixing water and CO2 with soft drink syrup to make a soda pop mixture; a pump for pumping soft drink syrup to the mixing station and beyond to be dispensed; a CO2 container providing CO2 gas; and a soda pop dispenser apparatus. The system also includes a first tubing transmission line extending between the soft drink syrup container and the pump for carrying soft drink syrup, a second tubing transmission line for carrying soft drink syrup between the pump and the mixing station, and a third tubing transmission line extending between the mixing station and the soda pop dispenser for carrying soda pop to be dispensed.

Abstract: A reusable medication delivery device that can determine medication remaining in a simple fashion. The device includes a first sensor (200) for sensing when a cartridge is mounted in the device, and at least one second sensor for sensing a retraction of a drive member (160) that engages a cartridge plunger (132). The device includes a controller that determines, based on inputs from the first sensor and the at least one second sensor, that a newly installed cartridge is to be considered full or not full of medication. The controller calculates, after a medication delivery and based on an input from a means for determining an amount of medication delivered by operation of a dose delivery mechanism, and if the cartridge was considered full when newly installed, a quantity of medication remaining in the installed cartridge after the medication delivery.

Abstract: Systems and methods for continuous infusion of a fluid, which may be heated, into a balloon catheter. A system for balloon inflation, the system comprising a catheter having an inflow lumen and an outflow lumen, a balloon positioned at a distal end of the catheter, the balloon being in fluid communication with the inflow and the outflow lumen, and an infusion device in fluid communication with the balloon through the inflow and outflow lumens, the infusion device configured for continuously circulating a fluid into and out of the balloon to maintain the balloon at a constant pressure and volume by matching a flow of the fluid into the balloon via the inflow lumen with a flow of the fluid out of the balloon via the outflow lumen in order to keep the balloon volume and pressure constant during an entire infusion.

Abstract: A method and apparatus are provided for use in locating a target region which is situated in the body of a subject, for example for the delivery of drugs. The system includes an assembly for controlling the flow of fluid from a fluid reservoir to a conduit, such as a needle. A sensor detects a characteristic indicative of the fluid pressure in the conduit. The system processes data from the sensor to detect the presence of a pulsatile waveform. A controller may control further operation of the system based on information regarding the presence of the pulsatile waveform and features of the waveform, such as amplitude.

Abstract: The invention is directed to an ophthalmosurgical system which includes a console for accommodating an irrigation fluid vessel containing irrigation fluid and a cassette, insertable into the console, for directing the irrigation fluid to a surgical instrument for an eye to be treated. An irrigation fluid flow path leads from the irrigation fluid vessel to the cassette and to the surgical instrument. A first fluid pump includes a first pump chamber having a first volume and a first drive chamber separated therefrom by a first elastic partition and having a second volume. A second fluid pump is arranged in parallel to the first fluid pump and includes a second pump chamber having a third volume and a second drive chamber separated therefrom by a second elastic partition and having a fourth volume. The first volume or the third volume has a magnitude within the range from 1 to 25 cm3.

Abstract: Some embodiments of a wearable infusion pump system can include a pump device having a drive system to dispense a medicine to a user, an activity sensor that detects a possible change in an activity level of the user, and a controller to activate the drive system to dispense the medicine to the user. The controller device can query the user to indicate whether a detected activity level of the user represents an actual change in the activity level of the user. The controller device can alter the medicine dispensing schedule based on the user indicated changes in activity level.

Abstract: A method is disclosed for state sensing and controlling of a multi-state drug delivery device. In some embodiments a power switch is reused as a state sensor. Optionally the state sensor may be toggled by user actions and/or the movements of parts of the device, for example needle and/or a protective element. Optionally, drug discharge and/or status indication is controlled in accordance with sensor output. In some embodiments control is by means of a processor. Alternatively or additionally, control is by means of simple physical circuits.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary infusion device includes a motor operable to deliver fluid to a body of a user, a first control module to enable input power for the motor and provide a dosage command for operating the motor, and a second control module coupled to the first control module to receive the dosage command and operate the motor using at least a portion of the input power based at least in part on the dosage command. One of the first control module and the second control module detects an anomalous condition, and in response, disables the input power to the motor, stores diagnostic information for the anomalous condition in its internal memory, and automatically resets thereafter.

Abstract: A method of removing blood from an extracorporeal blood circuit and/or a functional device, each of which is connectable or connected with a blood treatment apparatus for the purpose of a blood treatment of a patient, after concluding a blood treatment session, the method comprising operating a blood pump in a second conveying direction which is opposite to a first conveying direction of the blood pump which is customary during the blood treatment, and an arterial line section of the extracorporeal blood circuit is or will be connected with a venous line section of the extracorporeal blood circuit.

Abstract: Methods and apparatus for wireless power transfer and communications are provided. In one embodiment, a wireless power transfer system comprises a transmit resonator configured to transmit wireless power, a receive resonator configured to receive the transmitted wireless power from the transmit resonator, a medical device configured to receive power from the receive resonator, a controller configured to change an operating parameter of the medical device resulting in a change to a sonic signature of the medical device, and a listening device configured to determine an intended communication from the implanted medical device or the implanted receive resonator based on the change to the sonic signature coming from the implanted medical device.

Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.

Abstract: Methods, devices, and systems of delivering infusion fluid (e.g., medication such as insulin) can detect, at multiple times during a dispensation period of time, a pressure level of the infusion fluid in an infusion fluid pathway, either directly or indirectly. Based on the detected pressure levels, one or more actual dispensation times that are after an intended dispensation time can be determined. In some cases, methods, devices, and systems provided herein can use variable occlusion alarm thresholds, which can depend on variables such as an age of an infusion set and/or a current analyte level. In some cases, methods, devices, and systems provided herein can automate medication delivery and use the actual dispensation times in a control algorithm determining medication deliveries.

Abstract: A drug delivery system provides for controlled mixing of drugs, using at least one mixing chamber. Flow controllers guide drugs into single or multiple catheters, enabling a single lumen catheter to dispense multiple drugs, diluting a concentrated drug to provide varying drug concentration. A buffer fluid can deliver precise drug amounts or can separate drugs within a catheter. A patient's bodily fluid can serve as a diluent or buffer fluid. A drug testing/filler apparatus may be used to facilitate filling of multiple reservoirs. Bolus or continuous delivery of drug to selected distal locations can occur at independent rates. New catheter systems, hub assemblies, and uses therefore are also described. New methods for promotion of healthy pregnancy and treatment of a developing fetus are disclosed.

Abstract: Methods, computer systems and computer readable media provide validation of one or more infusions for a patient without requiring barcode scanning. In embodiments, identification that a clinician has entered a room with one or more infusions is received based on proximity information. The room is associated with a patient that has orders for the one or more infusions. The clinician is automatically logged into an electronic medical record (EMR) associated with the patient, including context based on the clinician entering the room with the one or more infusion. As a result, the one or more infusions are automatically validated for the patient.

Abstract: The present invention provides devices and methods for establishing aseptic connections between two or more components or subassemblies. The devices may be used in medical devices such as drug delivery pumps (10). In some embodiments, a connection is made between a drug container (50, 1050, 2050) and a fluid pathway connection assembly (300, 1300, 2300). The fluid pathway connection assembly may include a connection hub (312, 1312, 2312), a piercing member (316, 1316, 2316), and a piercing member retainer (314, 1314, 2314). The assembly may further include a first film (318, 1318, 2318) covering a cavity (312A, 1312A, 2312A), thereby maintaining the aseptic condition of the cavity. The drug container may hold a fluid drug and include a pierceable seal (326, 1326, 2326). A second film (322, 1322, 2322) may cover a recess (328, 1328, 2328) formed by the seal and thereby maintain the aseptic condition of the interior of the chamber.

Abstract: A technology is provided that enables high accuracy electrical measurement regardless of the performance of a measurement device. An electrical characteristic measurement apparatus includes a measurement unit that measures an electrical characteristic of a biological sample in a plurality of frequencies; and an assignment unit that performs assignment of a number of measurements and/or a measurement amplitude for each frequency. Use of a combination of a frequency for which the signal-to-noise ratio (SNR) is intentionally left low and a frequency for which the SNR is on the contrary improved when an electrical characteristic of a biological sample is measured in multiple frequencies, can provide, as a result, high accuracy electrical measurement optimal for the purpose of measurement.

Abstract: A medical device is disclosed. The medical device includes an RFID reader for receiving information from at least one RFID transponder. The medical device also includes a memory for storing a database and at least one processor for processing information. Also, a remote controller for a medical device is disclosed. The remote controller includes an information receiver for receiving information related to food. The infusion device also includes a memory for storing a database and at least one processor for processing information. A method for use in a medical device is also disclosed. The method includes receiving information from an RFID transponder related to food. Also, the processing the information by comparing the information to a database is included in the method. The method also includes determining the acceptability of the food and providing information related to acceptability to the user.

Abstract: A controller for an artificial pancreas for automated insulin delivery to patients with type 1 diabetes mellitus (T1DM) that enforces safe insulin delivery throughout both day and night, wherein the controller employs zone model predictive control, whereby real-time optimization, based on a model of a human's insulin response, is utilized to regulate blood glucose levels to a safe zone, and time-dependent zones that smoothly modulate the controller correction based on the time of day, wherein the controller strategically strives to maintain an 80-140 mg/dL glucose zone during the day, a 110-220 mg/dL zone at night, and a smooth transition of 2 hour duration in between.

Abstract: A device configured to deliver a medicament to a user by injection, comprising an injection feedback apparatus configured to apply temperature-based feedback to the user regarding the delivery of the medicament.

Abstract: The invention is directed to an ophthalmosurgical system which includes a console for accommodating an irrigation fluid vessel containing irrigation fluid and a cassette, insertable into the console, for directing the irrigation fluid to a surgical instrument for an eye to be treated. An irrigation fluid flow path leads from the irrigation fluid vessel to the cassette and to the surgical instrument. A first fluid pump includes a first pump chamber having a first volume and a first drive chamber separated therefrom by a first elastic partition and having a second volume. A second fluid pump is arranged in parallel to the first fluid pump and includes a second pump chamber having a third volume and a second drive chamber separated therefrom by a second elastic partition and having a fourth volume. The first volume or the third volume has a magnitude within the range from 1 to 25 cm3.

Abstract: Access devices may receive signals over a network and calculate a frequency spectrum of the received signals. An analyzer system may collect the frequency spectrum data from multiple access devices, and based on the collected data, detect, identify, and locate sources of anomalies in a communication network.

Abstract: A pump unit includes a drive motor (14) and a first housing (2), in which a control electronics unit (18) is arranged for operating the drive motor (14). An operating unit (20) having at least one display or operating element (26, 28, 30) can be detachably connected to the first housing in at least two different positions.

Abstract: A regional anesthesia injection apparatus comprising an injection volume determiner. The apparatus configured to determine a volume of a regional anesthetic injection into a target tissue; an injection pressure determiner configured to determine a pressure of the injection; and a controller coupled to the injection volume determiner and to the injection pressure determiner and configured to provide an injection signal to control injection of fluid into the target tissue based on the determined pressure and the determined volume.

Abstract: An infusion pump including an interface unit for receiving first data for a first infusion regimen for a medication, the first regimen including a first unit of measure in which the first regimen is executed and after receipt of the first data, second data for a second infusion regimen for the medication, the second regimen including a second unit of measure in which the second regimen is executed. The pump also includes a processor for comparing the first and second units of measure. In one embodiment, the pump includes a graphical user interface, and the processor identifies a difference between the first and second units of measure; generates, using the processor, a warning message; and displays the message on the graphical user interface. In another embodiment, the processor holds in abeyance initiation of the second infusion regimen in response to identifying the difference between the units of measure.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: A syringe pump is disclosed that includes a body, a syringe seat, a syringe actuator, a memory, and one or more processors. The syringe seat is coupled to the body. The syringe actuator is configured to actuate a syringe secured within the syringe seat. The memory is configured to store a plurality of instructions. The one or more processors, in accordance with the plurality of instructions, is/are configured to: prime the syringe pump in a prime phase; determine if an occlusion exists during the prime phase using a first test; stop the prime phase; initiate fluid delivery into a patient; enter into a start-up phase; determine if an occlusion exists using a second test during the start-up phase; transition from the start-up phase into a steady-state phase; and determine if an occlusion exists during the steady-state phase using a third test.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.