Abstract: A container comprises a bottle for a liquid product and having at the end of its neck a leakproof envelope enclosing an additional product to be stored separately from the liquid in the bottle. A cap on the neck includes a slidable push button carrying a perforator to open the envelope in a central region of the envelope to allow the additional product to mix with the liquid and then to be discharged through an eccentric duct in the cap rather than having to pass through the center of the cap where the perforator is positioned.

Abstract: An improved additive transfer device for storing and subsequently transferring a fluid material from an additive container to a rigid or semirigid solution container having an exposed closure. The improved additive transfer device is mounted on the additive container and includes a closure assembly fabricated from three components; a pierceable stopper, a slidable piercing pin and a hood member. The closure assembly is adapted to be positioned on the solution container. The two ended slidable piercing pin is disposed in a central opening in the pierceable stopper so that one end will pierce a diaphragm contained in the pierceable stopper. Resistance elements are provided between the slidable piercing pin and the central opening in the pierceable stopper to hold the slidable piercing pin away from the diaphragm in the pierceable stopper in one position and allow the slidable piercing pin to pierce the diaphragm and retain it within the central opening in a second position.

Abstract: A mixing container and an adapter to interconnect the mixing container to a second container to permit intermixing of the contents of the containers. The mixing container has a neck with a plurality of raised circumferential ribs thereon. The adapter has a central cylindrical sleeve. A first end of the sleeve is surrounded by a cylindrical skirt. The interior surface of the first end of the sleeve has a plurality of circumferential grooves which enable the adapter to engage the ribs on the neck of the mixing container. The interior surface of the cylindrical skirt has a screw thread to enable the adapter to engage a conventional threaded container neck. The opposite, or second, end of the sleeve has a cutting sleeve therein, concentric with the sleeve. The cutting sleeve is adapted to pierce a seal on the mixing container. The second end of the sleeve frictionally engages the raised circumferential ribs on the mixing container during the mixing operation.

Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by attaching an additive assembly with a piercing element to an additive port of the diluent container to pierce a diaphragm in the additive port and a diaphragm or stopper in the additive container. In one embodiment, the additive assembly includes a bellows portion which will permit movement of the piercing element through the additive assembly stopper and the port diaphragm while maintaining a sterile medicament in a glass vial.

Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by moving a piston member with a piercing element in the direction of the diluent container to pierce a diaphragm or stopper in the medicament container. In one embodiment, the medicament container is sealed by means of a flange to the diluent container wall and the piercing element will pierce a diaphragm and the container wall with the piercing member also serving as an injection site.

Abstract: A cannula assembly especially for medical use is disclosed which virtually eliminates coring during the piercing of a barrier. The cannula assembly includes a hollow cylindrical shank and a piercing tip removably mounted in and closing one end of the shank. Pressurized introduction of fluid through the shank forces the piercing tip out of engagement with the shank, placing opposite sides of the barrier in fluid communication.

Abstract: A sterile, closed drug delivery system (10) is provided comprising a flexible container (12), a capsule (22) coupled to the flexible container and a standard glass drug vial (36) positioned within the capsule. The flexible container has a liquid diluent therein. The capsule has supporting legs (32-35) which extend inwardly from the capsule to support the vial and also a highly flexible, pleated cap (28) which enables the drug vial to be manually moved relative to the supporting legs. The capsule is coupled to the flexible container by means of a hollow spike (54) located within the capsule and a frangible member (58) located within the flexible container, which frangible member allows fluid passage only when it is broken. Manual pressing of the pleated cap moves the drug vial downwardly onto the spike, piercing the stopper of the drug vial. Once the frangible member is broken, there is sterile communication between the drug vial and the liquid diluent contents of the flexible container.

Abstract: A multi-cartridge syringe assembly includes one cartridge containing a diluent and insertable within another cartridge containing dry medication. The nose of the diluent cartridge supports a cannula and is surrounded by a lock head member. In an initial mode, the exposed cannula is surrounded by a resilient cover. A retaining element extending rearwardly from a piston in the medication cartridge includes lock elements sequentially engageable with first and second annular devices on the lock head member as the two cartridges are axially displaced towards each other. In a first position the two cartridges are locked together without any axial displacement between the cannula and its cover while in a second position the cover is forced rearwardly of the cannula as the point of the cannula pierces the cover as well as the piston in the medication cartridge.

Abstract: A multimedication syringe for temporary storage and injection of at least two fluid substances comprising a hollow tubular housing having a generally cylindrical wall, an open rear end and a generally tapered partially closed front end defining a discharge passage; a plunger including a portion sized for moving axially within the housing through substantially the entire length thereof, the portion including a plug surrounding the portion for engaging the inner surface of the housing in a fluid-tight manner, the plunger for forcing fluid in the housing out the discharge passage when the plunger is moved axially within the housing from the open end toward the discharge passage; and a resealable tube in the wall of the housing for transmitting fluid into the housing.

Abstract: The invention relates to a device to one end of which a syringe can be connected and to the other end of which the mouth or opening of a bottle containing a drug or medicine can be connected. The device comprises a closed chamber having enclosed therein a needle which is in connection with the syringe. Members are provided by means of which the mouth or opening of the bottle is steadily connected to the device and means enabling the needle to perforate a seal plug and then a small rubber plug mounted on the bottle only when the device is blocked onto the bottle so that in any case it cannot be disconnected therefrom. Such a device can be disconnected from the bottle only after the needle has been caused to reenter the closed chamber, so as to prevent any possible dripping of the liquid outside of the device.

Abstract: The invention relates to a hypodermic syringe comprising a cartridge having connected thereto an injection needle, a medicament holder closed by means of a piercible stopper, and a telescopic assembly which detachably connects the cartridge and the holder. The part of the injection needle extending within the telescopic assembly is surrounded entirely by a sheath of a flexible material the closed end of which bears against or is present at a short distance from the stopper of the medicament holder.

Abstract: A kit for the perfusion of sodium nitroprusside and sodium thiosulfate contains as components (1) a container of sodium thiosulfate aqueous solution, (2) a light-opaque syringe, (3) light-opaque tubing, and (4) an ampoule containing lyophilized sodium nitroprusside. Alternatively the kit includes (1) a light-opaque container of mixed sodium nitroprusside-sodium thiosulfate solution, (2) a light-opaque syringe, and (3) light-opaque tubing.

Abstract: A catheter plug for sealing the proximal end of a parenterally placed catheter and permitting repeated small volume injections and delivery of parenteral fluids without disturbing the sterility of the catheter. The catheter plug has a compression chamber for applying compression to a self-sealing elastometric septum thereby enhancing the septum's self-sealing characteristics. Compression force is applied to the septum by screw movement between oppositely threaded male and female couplers. The catheter plug is particularly useful in situations where pressures higher than arterial pressures are encountered or where it is desirable to leave the catheter indwelling for long periods of time.

Abstract: A wet-dry syringe for combining and mixing a liquid and a solid medicament or at least two dissimilar liquid medicaments prior to the application thereof to a patient includes a first vial having liquid or solid medicament disposed between a pair of identical vial seals. A second vial functions as a piston rod and includes a pair of end seals with a liquid medicament disposed therein. One of the second vial seals includes a hollow piercing needle which when utilized to pierce one end seal of the first vial causes the medicament therein to flow into the first vial thereby mixing the medicaments prior to application to a patient by means of a needle piercing assembly which pierces the second of the first vial seals and the patient to which the mixed medicaments are to be infused. The second vial functions as a piston rod and aides in the discharge of the medicaments.

Abstract: A closed system for separately storing and selectively mixing two components, such as a drug and a diluent, under sterile conditions. The closed system can incorporate a drug vial of standard construction. A unique junction of the closed system permits a drug vial with a drug therein to be connected in a sterile manner with a compressible chamber having a diluent therein, after the drug and diluent have been separately sterilized. The junction encloses the end portions of access means to each of the receptacles, maintaining the end portions in sterile, spaced relation and providing for the selective establishment of a sterile pathway between the drug and diluent for mixing in a closed environment. The compressible chamber is of a unique design including gas-trapping and reservoir compartments in open communication. The compressible chamber is utilized with the junction to provide an efficient, sterile storage and mixing system.

Abstract: A sterile container for a medicinal material which is to be intermixed in an I.V. solution wherein the container serves as a mixing device as well as a portion of an I.V. administration apparatus. The device of this invention includes a container which is closed at opposing ends by pierceable diaphragm portions. Extending from one end is a piercing pin having a diaphragm piercing portion which can pierce the diaphragm when it is moved inwardly into the container and also provide a fluid passageway for the container contents. At the opposing end a diaphragm is housed in a closure with a tubular guide section for the piercing pin of an I.V. administration set. The container therefore serves a dual function of holding a fluid material such as a powder in a sterile condition yet serving as a component of an I.V. set to thereby afford a quick and simple procedure for mixing additive components into an I.V. administration set.

Abstract: A sterile container for a medicinal material which is to be intermixed in an I.V. solution wherein the container serves as a mixing device as well as a portion of an I.V. administration apparatus. The device of this invention includes a container which is closed at opposing ends by pierceable diaphragm portions. Extending from one end is a piercing pin having a diaphragm piercing portion which can pierce the diaphragm when it is moved inwardly into the container and also provide a fluid passageway for the container contents. At the opposing end a diaphragm is housed in a closure with a flexible end wall and a tubular guide section for the piercing pin of an I.V. administration set. The container therefore serves a dual function of holding a fluid material such as a powder in a sterile condition yet serving as a component of an I.V. set to thereby afford a quick and simple procedure for mixing additive components into an I.V. administration set.