Controlled Release Therapeutic Device Or System Patents (Class 604/890.1)
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Patent number: 9378333Abstract: This document discusses, among other things, an apparatus comprising a pump configured to deliver insulin, a processor, and a user interface including a bistable display. A display element of the bistable display is placed in one of two stable orientations upon application of a biasing voltage and stays in the stable orientation when the biasing voltage is removed. The processor includes a display module configured to display a non-blank reversion display screen on the bistable display when no input is received at the user interface after a specified time duration, and to recurrently change the reversion display screen until input is received at the user interface.Type: GrantFiled: September 23, 2011Date of Patent: June 28, 2016Assignee: Smiths Medical ASD, Inc.Inventors: Michael Blomquist, Timothy Bresina, Gail Bynum, Michael Welsch
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Patent number: 9372404Abstract: The invention provides an organic film composition comprises (A) a heat-decomposable polymer, (B) an organic solvent, and (C) an aromatic ring containing resin, with the weight reduction rate of (A) the heat-decomposable polymer from 30° C. to 250° C. being 40% or more by mass. There can be provided an organic film composition having not only a high dry etching resistance but also an excellent filling-up or flattening characteristics.Type: GrantFiled: April 30, 2013Date of Patent: June 21, 2016Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takeru Watanabe, Seiichiro Tachibana, Toshihiko Fujii, Kazumi Noda, Toshiharu Yano, Takeshi Kinsho
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Patent number: 9358033Abstract: A minimally invasive skin treatment system includes a platform having a recessed area on its bottom and one or more injection ports orthogonal to its top, each injection port including a through-hole to the recessed area. The system includes an injection device including a needle slidably disposed in a selective port such that the needle passes into the recessed area and percutaneously through a dermis disposed within the recessed area. A nozzle is configured to discharge a fluid at a high pressure in a direction orthogonal to an axis of the needle and parallel to the top of the platform to cut create a plane of dissection within the subcutaneous tissue.Type: GrantFiled: May 25, 2010Date of Patent: June 7, 2016Assignee: Ulthera, Inc.Inventors: Sowmya Ballakur, Robert L. Clark, III, James E. Chomas, Ben F. Brian, III, David M. Clapper
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Patent number: 9333282Abstract: The invention relates to a wound-stimulating unit comprising a wound-stimulating device for use in combination with a vacuum assisted closure. The closure comprises a hydrophilic body to be placed on a wound surface, a cover sealing the hydrophilic body and a skin portion surrounding the wound surface, and a vacuum system for generating an underpressure in a closure space limited by the wound surface, the skin portion surrounding the wound surface and the cover. Further, the wound-stimulating device comprises a connector provided with an intermediate channel structure having an input section and multiple output sections, the device further comprising a pressure system for supplying wound stimulating agents to the input section of the intermediate channel structure.Type: GrantFiled: August 30, 2006Date of Patent: May 10, 2016Assignee: KCI Medical ResourcesInventor: Rene Remmelt Willie Johan Van der Hulst
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Patent number: 9327076Abstract: An electronically and remotely controlled pill (500) or medicament delivery system is provided. The pill (500) includes a housing (102); a medicament reservoir (104) for storing a medicament; an electronically controlled release valve or hatch (106) for dispensing one or more medicaments stored in the medicament reservoir (104) while traversing the gastrointestinal tract; control and timing circuitry (108) for opening and closing the valve (106); and a battery (109). The control and timing circuitry (108) opens an closes the valve (106) throughout a dispensing time period in accordance with a preset dispensing timing pattern which is programmed within the control and timing circuitry (108). RF communication circuitry receives control signals for remotely overriding the preset dispensing timing pattern, reprogramming the control and timing circuitry (108) or terminating the dispensing of the medicament within the body.Type: GrantFiled: August 26, 2013Date of Patent: May 3, 2016Assignee: Medimetrics Personalized Drug DeliveryInventors: Karen I Trovato, Gerhard Spekowius
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Patent number: 9320576Abstract: Described is an orthodontic aligner implement that can ensure the accuracy and efficiency of clear aligner orthodontic therapies as well as increase patient compliance by reducing discomfort and combining functionality into a breath-freshening medium. The implement includes a consumable mass having at least two channels disposed on opposite sides of the mass and traversing the width of the mass. The channels are adapted to seat between opposing anterior or incisor teeth. Also described is a method of positioning an orthodontic aligner into a prescribed position that includes placing the aligner approximately in the prescribed position in one's mouth, placing the aligner implement described above into the mouth, and applying the implement in contact with the aligner in one's mouth.Type: GrantFiled: June 20, 2014Date of Patent: April 26, 2016Inventor: David A. Pechersky
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Patent number: 9314430Abstract: An elongate dosage form of generally cylindrical shape having two opposing ends, the dosage form being buoyant in. gastric fluid, wherein the dosage form is weight biased such that. one end is heavier than the ether end. The dosage form is adapted to float on gastric fluid with its long axis substantially perpendicular to the surface of the: fluid with its heavier end pointing: generally; downwards and into the fluid.Type: GrantFiled: July 4, 2011Date of Patent: April 19, 2016Assignee: Jagotec AGInventors: Pascal Grenier, Alain Nhamias, Guy Vergnault
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Patent number: 9259175Abstract: A wearable, conductive textile patch is provided that may include any of a number of features for monitoring body analytes and/or delivering fluids to a body. In one embodiment of the invention, a single, patch-mounted system monitors glucose levels of a diabetic person and provides appropriate doses of insulin in response to the glucose measurements. A hand-held user interface can be provided for wirelessly controlling the system and/or receiving information from it. Conductive pathways can be formed in the fabric of the patch. Components that can be integrated into the flexible patch include a power source, controller, transmitter, antenna, temperature and other sensors, fluid pump, infusion set, electrical pathways, switches, controls, electrodes, connectors, resistors and other circuit elements. Such components can be embedded, interwoven or coated on to the flexible patch instead of or in addition to surface mounting. Methods associated with use of the flexible patch system are also covered.Type: GrantFiled: October 23, 2006Date of Patent: February 16, 2016Assignee: ABBOTT DIABETES CARE, INC.Inventor: Gary Ashley Stafford
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Patent number: 9220838Abstract: A puncture device comprising a hollow needle, a fixing portion fixed to the hollow needle, a sheath portion covering a part/entirety of the hollow needle and including a plastically deformable elongating member, a holding portion holding the hollow needle and the sheath portion in an integrated manner, with the holding portion positioned between the tip portion of the hollow needle and the plastically deformable elongating member, a holding release mechanism that releases the holding of the holding portion between the hollow needle and the sheath portion after the hollow needle and the sheath portion puncture the living body. The sheath portion elongates and is held in an elongated condition when the holding portion moves by the holding release mechanism, or when the holding of the hollow needle using the holding portion in an integrated manner is released, and the elastic portion contracts.Type: GrantFiled: March 25, 2014Date of Patent: December 29, 2015Assignee: TERUMO KABUSHIKI KAISHAInventors: Takahiro Soma, Hiromasa Kohno
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Patent number: 9192715Abstract: A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.Type: GrantFiled: March 21, 2014Date of Patent: November 24, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark Gelfand, Howard R. Levin
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Patent number: 9186175Abstract: A surgical access assembly and method of use is disclosed. The surgical access assembly comprises an outer sheath and an obturator. The outer sheath and obturator are configured to be delivered to an area of interest within the brain. Either the outer sheath or the obturator may be configured to operate with a navigational system to track the location of either within the brain. Once positioned at a desired location, the obturator is removed, leaving a distal end of the outer sheath adjacent an area of interest, and creating a working corridor. Interventional devices may be introduced to the area of interest, as well as a variety of treatments. A subsequent treatment process may also be employed.Type: GrantFiled: April 11, 2012Date of Patent: November 17, 2015Assignee: Nico CorporationInventors: Joseph L. Mark, Amin Kassam
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Patent number: 9174009Abstract: A fluid medicament delivery device includes a patient attachment unit, containing the fluid medicament, and an indicator unit adapted to be detachably coupled to the patient attachment unit. A method for monitoring the fluid medicament includes independently setting a flow rate of a fluid medicament with the patient attachment unit. A pressure and/or a flow rate of the fluid medicament is sensed with a sensor located in a separate indicator unit in a sensing mode. A status of the fluid medicament delivery device is determined based at least in part on the pressure and/or the flow rate.Type: GrantFiled: September 25, 2013Date of Patent: November 3, 2015Assignee: CEQUR SAInventors: Gregory H. Peatfield, Peter Gravesen
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Patent number: 9173857Abstract: A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising a pharmaceutically active amphetamine salt covered with an immediate-release coating and a pharmaceutically active amphetamine salt covered with an enteric coating wherein the immediate release coating and the enteric coating provide for multiple pulsed dose delivery of the pharmaceutically active amphetamine salt. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.Type: GrantFiled: September 26, 2014Date of Patent: November 3, 2015Assignee: Shire LLCInventors: Amir Shojaei, Stephanie Read, Richard A. Couch, Paul Hodgkins
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Patent number: 9168364Abstract: A micro-needle delivery device (1) comprises an active substance accommodating layer (17) having active substance accommodating chambers (20) therein, a drive substance accommodating layer (32) having drive substance accommodating chambers (35) therein aligned with the active substance accommodating chambers (20), an activating layer (45) having heating elements (48) aligned with the drive substance accommodating chambers (35) for heating a drive substance therein, and a micro-needle element (8) having a needle support layer (9) and a plurality of micro-needles (12) extending therefrom. A burstable first membrane (22) is located between and sealably secured to the micro-needle element (8) and to the active substance accommodating layer (17) for sealably closing the active substance accommodating chambers (20) at one end.Type: GrantFiled: November 4, 2009Date of Patent: October 27, 2015Assignee: JANISYS LIMITEDInventors: John O'Dea, Eoin Bambury
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Patent number: 9167990Abstract: A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of optical characteristics may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose or mark the intestinal tract at a determined location along its length.Type: GrantFiled: December 23, 2013Date of Patent: October 27, 2015Assignee: Entrack, Inc.Inventor: Mir A. Imran
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Patent number: 9155654Abstract: Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.Type: GrantFiled: February 17, 2012Date of Patent: October 13, 2015Assignee: GLAUKOS CORPORATIONInventors: Hosheng Tu, Jason Artof, David Steven Haffner, Gregory T. Smedley, Barbara A. Niksch
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Patent number: 9132085Abstract: Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.Type: GrantFiled: April 8, 2009Date of Patent: September 15, 2015Assignee: Warsaw Orthopedic, Inc.Inventors: Phillip E. McDonald, Amira Wohabrebbi, Christopher M. Hobot, Vanja M. King
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Patent number: 9127782Abstract: A microfluidic valve including a microchannel, a membrane arranged so as to seal off the microchannel and equipped with resistive units, characterized in that at least one face of the membrane includes at least one groove, and in that the resistive units are arranged in the groove and are capable, when an electric control current flows through them, of expanding sufficiently under the effect of the heat produced by the flow of the electric current to cause the rupture of at least one part of the membrane.Type: GrantFiled: April 23, 2010Date of Patent: September 8, 2015Assignees: Commissariat a l'energie atomique et aux energies alternatives, UNIVERSITE JOSEPH FOURIERInventors: Marjolaine Allain, Skandar Basrour, Jean Berthier, Patrick Pouteau
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Patent number: 9114111Abstract: Method are provided for treating a patient having bladder pain and/or irritative voiding symptoms. The method includes administering to the patient's bladder lidocaine or another anesthetic agent continuously over a treatment period of 24 hours or more in an amount effective to achieve a therapeutic effect which is sustained beyond the end of the treatment period.Type: GrantFiled: January 10, 2012Date of Patent: August 25, 2015Assignee: Allergan, Inc.Inventors: Julie Himes, Dennis Giesing, Cheryl Larrivee-Elkins, Michael J. Cima, Purnanand Sarma, Paul Goldenheim
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Patent number: 9078805Abstract: A method that relates to the fields of polymer chemistry, pharmacy and medicine and releases drugs as a component of implants into the environment of the implant. A method that, in a simple and easily reproducible manner, generates a drug delivery system, which releases drugs in a locally targeted and controllably delayed manner. Polyanions and polycations are mixed in a liquid in a non-stoichiometric ratio, relative to the charged monomer units, wherein drugs are added to the polyelectrolytes either before, during or after the mixing, or charge-carrying drugs and an oppositely charged polyelectrolyte are mixed, and after the mixing the polyelectrolyte complex produced is applied to the surface of a medical structure or material or is positioned on the surface directly at the location where the drug is to be released.Type: GrantFiled: March 30, 2011Date of Patent: July 14, 2015Assignee: LEIBNIZ-INSTITUT FUER POLYMER-FORSCHUNG DRESDEN E.V.Inventor: Martin Mueller
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Patent number: 9078963Abstract: Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device.Type: GrantFiled: June 15, 2012Date of Patent: July 14, 2015Assignee: Asante Solutions, Inc.Inventor: Mark C. Estes
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Patent number: 9039680Abstract: Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.Type: GrantFiled: April 21, 2008Date of Patent: May 26, 2015Assignee: Acclarent, Inc.Inventors: Joshua Makower, John Y. Chang, Julia D. Vrany, Amrish Jayprakash Walke
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Patent number: 9039679Abstract: Embodiments of the invention are directed to systems, methods and devices for sustained medical infusion with controlled rate injection of a fluid into a body. Such a system may include a first separate reusable unit, a second separate depletable unit a third separate disposable unit having a cannula, and may include a fourth separate remote control unit. Emission of appropriate instructions from the fourth unit, when the first unit, the second unit, and the third unit are coupled together in associative operation and disposed on the skin, power is supplied to an engine for generating motion to a fluid transfer system, and when the cannula is inserted in the body, fluid is transferred from the reservoir to the body, via the tube and the cannula.Type: GrantFiled: October 18, 2013Date of Patent: May 26, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Ofer Yodfat, Avi Neta, Gavriel J. Iddan
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Publication number: 20150141967Abstract: The invention relates to an electronic pill (102) for delivery of a medication (104) inside a mammal. The electronic pill (102) comprises a reservoir (106) for releasing the medication (104) in response to a predefined level of pressure. Furthermore a primary elastic element (108) is comprised for applying said predefined level of pressure to the reservoir (106) via a piston (110) upon release from the piston (110) of its constrained position. The piston (110) in its turn, when in constrained position, induces a predefined level of stress in the primary elastic element (108) by accordingly deforming it. The electronic pill (102) comprises a mechanism (114) for changing, upon actuation, from a constraining configuration in which the piston (110) is maintained at its constrained position to a releasing configuration in which the piston (110) is released.Type: ApplicationFiled: September 29, 2011Publication date: May 21, 2015Applicant: Medimetrics Personalized Drug DeliveryInventors: Michel Gerardus Pardoel, Hans Zou, Jeff Shimizu
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Patent number: 9022996Abstract: An insulin pump comprises a pump device, a control for the pump device, a memory, an operating element for operating the insulin pump and a method for controlling a user interface of the insulin pump are disclosed. The control is designed and programmed such that options for the user of the insulin pump are displayed by the user interface as a function of a user-specific preference profile stored in the memory and as a function of a current time and are provided for selection by using the operating element. The insulin pump can be designed in an auto-adaptive fashion, such that the control continuously updates the user-specific preference profile based on analyzing operating inputs of the user. Embodiments of the invention allow a large range of functions and simple operation, even in the case of miniaturized pumps.Type: GrantFiled: November 16, 2012Date of Patent: May 5, 2015Assignee: Roche Diagnostics International AGInventors: Andreas Eberhart, Michael Krieftewirth, Marcel Both
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Patent number: 9022973Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.Type: GrantFiled: December 17, 2008Date of Patent: May 5, 2015Assignee: New World Pharmaceuticals, LLCInventors: Frederick A. Sexton, Ian Ivar Suni, Cetin Cetinkaya, Stephanie Schuckers, Eduard Sazonov
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Patent number: 9017310Abstract: Devices and methods for transmucosal drug delivery are provided. A device includes a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject. The device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles.Type: GrantFiled: October 8, 2009Date of Patent: April 28, 2015Assignee: Palo Alto Research Center IncorporatedInventors: Scott Uhland, Eric Peeters
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Patent number: 9017311Abstract: An integrated diabetes management (IDM) system includes a safety layer which, in one configuration has two components, one located between a glucose sensor and a controller and a second component located between a controller and a pump, to monitor various aspects of signals and modify those signals for compatibility and safety purposes. In one application, the safety layer receives output control signals from a controller and modifies those control signals as a function of an actual amount of insulin delivered to the user. The safety layer allows for an increased level of safety in the IDM system and permits development of separate hardware and software upgrades with the safety layer assuring that compatibility between components will continue.Type: GrantFiled: March 18, 2013Date of Patent: April 28, 2015Assignee: Abbott Diabetes Care Inc.Inventor: Erwin S. Budiman
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Publication number: 20150112316Abstract: A method includes logically associating an intravenous catheter and an electronic patient record stored on a computer readable storage medium, wherein the electronic patient record includes medical information specific to an identified patient. An identification code of a syringe to be administered to the identified patient is read in order to identify a liquid contained in the syringe. The blocking member may be electronically actuated to provide fluid communication between a catheter chamber and a catheter line inserted into the identified patient, wherein the fluid communication is provided only while the syringe is received within the catheter chamber and only in response to determining that administration of the identified liquid to the identified patient is compatible within the medical information.Type: ApplicationFiled: October 23, 2013Publication date: April 23, 2015Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Gary D. Cudak, Lydia M. Do, Christopher J. Hardee, Adam Roberts
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Publication number: 20150112315Abstract: A system includes an intravenous catheter having a catheter chamber, a catheter line for insertion into a blood vessel of the identified patient, and an electronically actuatable blocking member providing selective fluid communication between the catheter chamber and the catheter line. A reader is secured to the catheter chamber for reading an identification code that identifies a liquid in a syringe received within the catheter chamber. A control system accesses an electronic patient record that includes medical information specific to an identified patient and runs an application program logically associating the intravenous catheter and the medical information specific to the identified patient, determining whether the administration of the identified liquid to the identified patient is compatible within the medical information specific to the identified patient, and controlling electronic actuation of the blocking member.Type: ApplicationFiled: October 22, 2013Publication date: April 23, 2015Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Gary D. Cudak, Lydia M. Do, Christopher J. Hardee, Adam Roberts
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Patent number: 9011376Abstract: The present invention provides a drug delivery device comprising a drug reservoir chamber (15) containing a substance (16) to be delivered in fluid connection with a drug administration means (17) and (18), and a hydraulic control chamber (9) containing an electrically controlled, non-gassing, volume changing means (13), a coupling means (14) coupling said hydraulic control chamber (9) to said drug chamber (15), the arrangement being such that a change in the electrical control means (11) causes a change in the volume of the volume changing means (13), the volume change being conveyed by the coupling means (14) to the drug chamber (15) such that the substance (16) is expelled from the drug chamber (15) towards the drug administration means (17) and (18).Type: GrantFiled: July 3, 2006Date of Patent: April 21, 2015Assignee: SteadyMed Ltd.Inventors: Amir Genosar, Jonathan Goldstein
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Patent number: 9014799Abstract: Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.Type: GrantFiled: October 8, 2009Date of Patent: April 21, 2015Assignee: Palo Alto Research Center IncorporatedInventors: Scott Uhland, Eric Peeters, Serena Wong
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Patent number: 9005169Abstract: A cannula insertion device includes a housing defining an opening for receiving therethrough a cannula and further defining a channel, and a cannula forming a lumen, the cannula adapted for sliding movement within the housing from a retracted position to an extended position. When the cannula is in the retracted position, the lumen is located remotely from the channel and the channel is in fluidic communication with the opening. When the cannula is in the extended position, the lumen is in fluidic communication with the channel.Type: GrantFiled: October 27, 2010Date of Patent: April 14, 2015Assignee: Cequr SAInventors: Peter Gravesen, Heiko Arndt
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Patent number: 9005184Abstract: For fixedly implanting a device for material or signal delivery or acquisition or a part of such a device in a human or animal body, an opening is provided in hard tissue of the body, the opening reaching through a hard tissue layer, e.g. through a cortical bone layer into cancellous bone underneath. The device includes a plug portion (P) and/or a cover portion (C) which includes a ring of a material having thermoplastic properties extending around the plug portion (P) or on a tissue facing surface of the cover portion (C). The opening provided in the hard tissue has a cross section at least in the area of its mouth that is adapted to the plug or cover portion such that the plug portion (P) can be introduced through the mouth of the opening or the cover portion (C) can be positioned over the mouth of the opening such that the ring extends around the opening, along its wall and/or on the hard tissue surface around its mouth.Type: GrantFiled: October 19, 2010Date of Patent: April 14, 2015Assignee: Woodwelding AGInventors: Jörg Mayer, Barbara Froesch, Mario Lehmann, Jens Langhoff, Thomas Knecht, Stephanie Mehl, Andrea Mueller
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Patent number: 9005187Abstract: An implantable oxygen generator system is disclosed. The implantable oxygen generator system includes a receiver configured to generate an electrical current, and an electrode set configured to deliver the electrical current to water molecules of an interstitial fluid within a tissue, wherein the electrical current electrolyzes the water molecules into oxygen molecules.Type: GrantFiled: February 3, 2010Date of Patent: April 14, 2015Assignee: Purdue Research FoundationInventors: Babak Ziaie, Teimour Maleki
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Patent number: 8998884Abstract: Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.Type: GrantFiled: November 9, 2005Date of Patent: April 7, 2015Assignee: The Invention Science Fund I, LLCInventors: Leroy E. Hood, Muriel Y. Ishikawa, Edward K. Y. Jung, Robert Langer, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Patent number: 8992471Abstract: The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.Type: GrantFiled: November 5, 2008Date of Patent: March 31, 2015Assignees: Nanocopoeia, Inc., Louisiana State University Health Sciences Center Office of ResearchInventors: Tammy R. Dugas, Alok Khandelwal, James John Kleinedler, III, John Devlin Foley
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Patent number: 8992512Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.Type: GrantFiled: December 8, 2011Date of Patent: March 31, 2015Assignee: Boston Scientific Scimed, Inc.Inventors: Robert E. Richard, Marlene C. Schwarz, Rudolf Faust
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Patent number: 8992511Abstract: Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.Type: GrantFiled: March 9, 2006Date of Patent: March 31, 2015Assignee: The Invention Science Fund I, LLCInventors: Leroy E. Hood, Muriel Y. Ishikawa, Edward K. Y. Jung, Robert Langer, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Patent number: 8992603Abstract: The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.Type: GrantFiled: October 2, 2012Date of Patent: March 31, 2015Assignees: Nanocopoeia, Inc., Louisiana State University Health Sciences Center Office of ResearchInventors: Tammy R. Dugas, Alok Khandelwal, James John Kleinedler, John Devlin Foley
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Patent number: 8986250Abstract: A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a pressure source engageable with the reservoir. The pressure source is movable between a first configuration and a second configuration wherein the pressure source exerts a pressure on the reservoir to urge the drug therefrom. An output conduit is provided for transmitting the drug into the individual. An actuation mechanism is operatively connected to the pressure source and the output conduit. The actuation mechanism is movable between a non-actuated position and an actuated position wherein pressure source moves from the first configuration to the second configuration and wherein the input of the output conduit communicates with the drug and the output end of the output conduit is receivable in the individual.Type: GrantFiled: August 1, 2008Date of Patent: March 24, 2015Assignees: Wisconsin Alumni Research Foundation, Ration, Inc.Inventors: David J. Beebe, Benjamin J. Moga, Tony Escarcega, Kent Chase
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Patent number: 8980297Abstract: An implant comprises a structure that may be implanted into tissue and that has a first material property at normal body temperature. The first material property is variable at elevated temperatures above normal body temperature. The implant also has a plurality of particles dispersed in the structure that are adapted to convert incident radiation into heat energy when irradiated with electromagnetic radiation. The particles are in thermal contact with the structure such that exposure of the particles to incident radiation raises the temperature of the structure thereby changing the first material property relative to the first material property at normal body temperature.Type: GrantFiled: September 28, 2010Date of Patent: March 17, 2015Assignee: J.W. Medical Systems Ltd.Inventors: Patrick H. Ruane, Cameron L. Wilson
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Publication number: 20150073393Abstract: A medical device system includes at least one controllable patient-worn or patient-carried medical device, and a plurality of controller devices that are capable of independently controlling features or functions of the patient medical device. Control commands and other data is wirelessly communicated among the patient medical device and the multiple controller devices. A number of techniques, protocols, and other measures are provided to coordinate wireless communication between the various devices in a medical device system. These control command coordination processes address situations where conflicting, redundant, or concurrent control commands might be independently issued by the multiple controller devices.Type: ApplicationFiled: November 10, 2014Publication date: March 12, 2015Inventors: Sheldon B. MOBERG, Ian B. HANSON
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Patent number: 8974439Abstract: Some embodiments an infusion pump system can provide a suggested bolus dosage based on particular parameters (e.g., the user's recent blood glucose characteristics, food intake data, an amount of insulin already delivered to the user which has not yet acted on the user, or other factors). In some circumstances, the infusion pump system can receive information indicative of the user's blood glucose level and suggest an insulin bolus dosage that is at least partially dependent upon the recent rate of change in the user's blood glucose level. Such a feature can be helpful to a user when the infusion pump is operated in conjunction with a glucose monitoring device because the suggested bolus dosage can be at least partially based on recent data indicative of the user's blood glucose level.Type: GrantFiled: January 2, 2009Date of Patent: March 10, 2015Assignee: Asante Solutions, Inc.Inventor: Mark C. Estes
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Patent number: 8971958Abstract: A portable personal medical device, e.g., a wearable insulin pump, is provided with a web server and is controllable over a network by a browser equipped client, thereby enabling comprehensive and comfortable control, operation and/or configuration of the device.Type: GrantFiled: October 10, 2007Date of Patent: March 3, 2015Assignee: Roche Diagnostics International AGInventors: Marcel Frikart, Markus Jungen
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Patent number: 8968274Abstract: Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.Type: GrantFiled: July 8, 2008Date of Patent: March 3, 2015Assignee: The Invention Science Fund I, LLCInventors: Leroy E. Hood, Muriel Y. Ishikawa, Edward K. Y. Jung, Robert Langer, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Patent number: 8961498Abstract: Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.Type: GrantFiled: June 18, 2009Date of Patent: February 24, 2015Assignee: Medimetrics Personalized Drug DeliveryInventors: Hans Zou, Jeff Shimizu, Lucian R. Albu, Johan F. Dijksman
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Patent number: 8951242Abstract: Provided is a bacterium-based microrobot, wherein bacteria are attached to a part of a surface of a microstructure including at least one or more magnetic particle, for actuating a bacterium-based microrobot more effectively.Type: GrantFiled: November 8, 2012Date of Patent: February 10, 2015Assignee: Industry Foundation of Chonnam National UniversityInventors: Suk Ho Park, Jong Oh Park, Sung Jun Park
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Patent number: 8945094Abstract: A method includes receiving measurements from a sensor associated with a patient at a portable medication delivery device. The method also includes controlling delivery of medication to the patient at the portable medication delivery device using a single input, single output (SISO) model predictive control technique. The SISO model predictive control technique includes predicting a characteristic of the patient using the measurements and a model associated with the patient. The SISO model predictive control technique also includes determining whether the characteristic of the patient is predicted to fall outside of a desired range. In addition, the SISO model predictive control technique includes, if the characteristic of the patient is predicted to fall outside of the desired range, determining an amount of medication to deliver to the patient and delivering the determined amount of medication to the patient.Type: GrantFiled: September 8, 2010Date of Patent: February 3, 2015Assignee: Honeywell International Inc.Inventor: Pernell E. T. Nordh
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Patent number: 8926594Abstract: An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.Type: GrantFiled: February 24, 2012Date of Patent: January 6, 2015Assignee: kaleo, Inc.Inventors: Eric Shawn Edwards, Evan Thomas Edwards, Mark J. Licata, Paul F. Meyers, David A. Weinzierl