Abstract: A dual-chamber syringe has a plunger within an inner delivery chamber in fluid communication with an ejection port. The deliver chamber is formed within a tubular element axially slidable within a tubular guide. The tubular guide and the syringe outer barrel form an outer reservoir chamber. The outer reservoir chamber is sealed from the delivery chamber while the tubular element is in a first position within the guide. Upon withdrawal of the plunger, frictional contact imparted by the plunger seal causes the tubular element to slide away from sealing engagement with the barrel into a second position within the guide. In the second position of the tubular element, a fluid passageway is opened from the reservoir to the delivery chamber allowing fluid to be drawn into the delivery chamber. A porous seal between the plunger rod and barrel allows air into the reservoir during transfer of fluid to the delivery chamber.

Abstract: A pre-filled syringe having an elastic-sliding valve to produce a hermetic closure inside a pre-filled syringe which keeps the liquid content to be injected totally isolated, in order to prohibit the liquid from coming in contact with the needle or the external air.

Abstract: A method and a needleless injection system for administering a medication. In order to simplify as far as possible the handling necessary for loading the injector with medication and thereby eliminate risks caused by a complex handling the method and system according to the invention provide loading of medication into a needleless injector device by means of a syringe prefilled with a medication, this loading step preferably including connecting the syringe to the injector device by means of a suitable coupling member or adapter and operating the syringe for transferring medication prefilled therein into the injector device. After this transfer the syringe and/or the coupling member or adapter are detached from the injector device, which is then ready to be operated for ejecting the loaded dosage of said medication from the injector device and thereby pass the selected dosage through the skin of an injection receiver.

Abstract: A controlled medicament security enclosure system that houses liquid filled reservoirs which consists of a portable enclosure (20) formed with a top half (22) and a bottom half (24) that permanently snap together to form a secure inseparable repository for the reservoirs. Inside the enclosure is at least one glass vial (36) for storing the liquid medicament with each vial having a sliding piston stopper (42) within that seals the inside of the vial and slides to maintain the liquid air free regardless of the volume. An adapter socket (48) is removably attached to the stopper and includes a hollow needle that pierces the stopper and permits a flowpath for the liquid. A flexible outlet tube (62) along with connectors on each end transmit the medicament to a mechanical drug delivery system that has a peristaltic pump and a control module.

Abstract: This reconstitution and injection system delivers a drug in solution under pressure, and injects powdered or lyophilized drugs that require reconstitution, rehydration or dilution. In one embodiment, the system includes a syringe having a barrel, a plunger, a handle, a pump and a channel communicating the barrel with an injection needle. The pump pushes a liquid from the barrel through the injection needle via the channel upon fluid communication between the barrel and the injection needle for delivery of the liquid. In another embodiment, the system includes a first port receiving a syringe, a second port receiving a drug vial, a channel providing communication between the first and second ports, and a controller permitting or inhibiting fluid communication between the first and second ports. In yet another embodiment, the system includes an actuator and a housing having a channel providing fluid communication between a reservoir and the injection needle.

Abstract: A closure element for sterile closure of connections, in particular connections of filter modules for dialysis, hemofiltration or ultrafiltration is described. A closure element with a simple design that provides a reliable seal is formed by having the closure element include a wall with an automatically closing slit-shaped indentation which when closed creates a germ-proof seal. The sealing element is used for sterile closure of connections of medical items, as well as for the medical items themselves.

Abstract: A fluid spray device comprising an outlet channel (120) terminating in a spray orifice (125), a first tank (110) containing a first substance, a second tank (210) containing a second substance, said two tanks (110, 210) being interconnected by a passage (160, 260) and prior to actuation of the device, being separated from each other in leakproof manner by sealing means (115, 215) disposed in said passage (160, 260), mixer means (130, 135; 235) being provided to open said passage (160, 260) and to mix together the two substances before they are dispensed, and dispenser means (235, 135) being provided for dispensing said mixture, the device being characterized in that said sealing means comprise at least one ball (115, 215) adapted to be expelled from the passage (160, 260) by said mixer means (130, 135; 235), said mixer means comprising a first piston (135; 235) slidably received in one of the tanks (110; 210) to transfer one of the substances from its tank (110; 210) into the other tank (210; 110), said dispe

Abstract: A closure element for sterile closure of connections, in particular connections of filter modules for dialysis, hemofiltration or ultrafiltration is described. A closure element with a simple design that provides a reliable seal is formed by having the closure element include a wall with an automatically closing slit-shaped indentation which when closed creates a germ-proof seal. The sealing element is used for sterile closure of connections of medical items, as well as for the medical items themselves.

Abstract: Multi-sectioned fluid delivery devices with sensor membranes for use in detection of target molecules in gas or liquid samples are provided.

Abstract: An apparatus for altering characteristics of a fluid. The apparatus includes a canister having a side wall, a first end wall, and a second end wall defining a chamber therein. A beneficial agent is disposed in the chamber. The end walls define apertures therethrough. The apparatus further includes a tubing portion defining a first end portion constructed for connection to a fluid source and an outlet portion. The tubing portion also defines a canister-receiving portion intermediate the first end portion and the outlet portion. The canister-receiving portion defines a first fluid flow channel fluidly connecting the first end portion and the second outlet portion of said tubing portion. The canister-receiving portion also defines first and second fluid flow orifices therethrough.

Abstract: The present invention provides a receptacle used in a passive drug delivery system. The receptacle includes first flow path for supplying along a fluid conduit a medical liquid, second flow path for introducing the medical liquid into a container containing a beneficial agent, third flow path for delivering a mixed solution containing the medical liquid and agent, and a guide valve for controlling the flow path by closing or opening the flow path.

Abstract: A resealable vial featuring a fluid access device having a membrane for selectively opening or sealing a fluid passageway between the bottle and the fluid access device. The vial includes a body disposed on said bottle. The fluid access device can be configured as a spike assembly, a needle assembly, or a luer lock assembly, and features a hollowed rod in sliding, fluid-tight relation to an orifice defined by the body. A membrane, preferably formed from an elastomeric material, is secured across both the orifice and the open top of the bottle, and may be retained between the top surface of the bottle and the body. The membrane preferably includes a central area sealing the orifice from the open top of the bottle, with one or more fluid passages defined on a portion of the membrane outside of the central area.

Abstract: A prefilled, two-constituent system is provided with first and second containers or barrels. The first barrel includes a first chamber having a dispensing end or delivery end. The delivery end defines a dispensing passage or delivery passage communicating through the delivery end to accommodate the dispensing of fluid from the first chamber. A movable seal or reciprocable stopper is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the delivery end and the stopper. A second container or barrel is sized to be disposed in the first barrel and has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the second barrel. A plunger is slidably disposed within the second barrel. A liquid second constituent is provided in the second barrel between the discharge end and the plunger.

Abstract: An apparatus for controlled delivery of a liquid consists of a delivery unit which comprises a liquid container (3) having at least one movable wall (12) and a liquid outlet which is provided with a flow restriction, and a power unit which comprises a second container (21) which also has at least one movable wall (29) and wherein a vacuum may be established, and a mechanical coupling (31) between the movable wall (12) of the liquid container(3) and the movable wall (29) of the second container (21). The delivery unit and the power unit are connected together coaxially when the apparatus is prepared for delivery, and in this connecting together, the movable wall (29) of the second container is displaced by means of the mechanical coupling (31) such that the vacuum is established.

Abstract: An apparatus for separately storing a medicament component, such as a drug and for mixing this component with a liquid component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the liquid component. The device includes a novel collapsible vial structure which can be used for controllably introducing a support structure carrying the medicament component into the liquid container whereby the medicament and liquid components will thoroughly mix under sterile conditions.

Abstract: A resealable assembly for a container such as a bottle or vial featuring a membrane for selectively opening or sealing a fluid path between the bottle and a medical delivery device introduced into the assembly. The assembly includes a body disposed on said bottle, and a luer connector hub which may be separately provided with the body or formed integrally therewith. The luer connector hub features a connector end open for access by the medical delivery device, and an opposed end which is disposed for fluid communication with the open top of the bottle. A membrane, preferably formed from an elastomeric material, is secured across both the opposed end of the luer connector hub and the open top of the bottle, and may be retained between the top surface of the bottle and the body. The membrane preferably includes a central area sealing the opposed end of the luer connector hub from the open top of the bottle, with one or more fluid openings defined on a portion of the membrane outside of the central area.

Abstract: Methods and apparatus are provided for mixing and dispensing multi-component compositions. The preferred embodiment utilizes a syringe barrel as a mixing chamber and for dispensing of the mixed components. A mixer element, preferable including a paddle member and finger grip means for rotating the paddle member, is provided for insertion into the syringe barrel to effect the desired mixing. A scraper element is used to scrape mixed components from the mixer element so as to retain the mixed components within the syringe barrel upon removal of the paddle member after mixing is completed. Mixing is preferably performed with the multiple components placed in side-by-side orientation within the syringe barrel rather than one on top of another.

Abstract: A prefilled, two-constituent system is provided with first and second containers. The first container includes a first chamber having a dispensing end. The dispensing end defines a dispensing passage communicating through the dispensing end to accommodate the dispensing of fluid from the first chamber. A movable seal is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the dispensing end and the seal. A second container includes a barrel that is sized to be disposed in the first container and that has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the barrel. A plunger is slidably disposed within the barrel. A liquid second constituent is provided in the barrel between the discharge end and the plunger.

Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for controllably ejecting the first component from the glass vial so that it will fall by force of gravity into the second container whereby the first and second components will thoroughly mix under sterile conditions.

Abstract: A unitary syringe assembly including a diluent syringe and a jell syringe stores and enables convenient transport of isolated components required for injection. A valve is placed between the two syringes. Immediately before required injection, the valve is opened and intermixing injection and reception of the diluent and jell between the two syringes occurs to thoroughly intermix the diluent and jell. The valve aperture size is selected to provide viscous resistance by the jell until thorough mixing has occurred to provide the user with a tactile indication of sufficient mixing. Upon complete mixing, a needle is attached and injection occurs. Paired side-by-side unitary syringes are utilized with an interconnecting mixing manifold with injection occurring from one syringe only to enable higher needle injection pressure.

Abstract: A valved medication container for facilitating needleless transfer of medication from the container to a patient. Four embodiments of valve members are disclosed. The first embodiment employs a slidable actuator which is engaged by the nose portion of a syringe and deflected into the container through a slit elastomeric membrane. A second embodiment employs a duckbill which the nose of the syringe biases to an open position. The third embodiment uses axially opposed flapper valves which the nose of the syringe pushes open. The fourth embodiment employs a slidable actuator with a T-shaped passageway which is moved to the open position by the syringe. A vent having a one-way valve for influx of air is provided for larger containers.

Abstract: An infusion port for subcutaneous placement and dialysis procedures is shown and described as including two chambers, two corresponding large area membrane access panels, and two corresponding barbs providing access between the infusion port and a patient's blood circulatory system. A valve selectively couples the chambers and the barbs in one state, and in another state isolates the barbs and couples directly the two chambers. The valve can operate externally by pressure applied to patient's skin. Hemodialysis is performed in the first state, and in the second state the port is flushed clean of residual blood by injecting cleansing fluid into one chamber and withdrawing it from the other. Also disclosed, an access needle includes a tube carrying a removable penetration pin. The tube fluidly couples to an external barb. The needle is fluidly coupled to the infusion port by driving the needle through the skin of the patient and membrane of the infusion port.

Abstract: An IV bag has at least one opening and a valve associated with the opening. The valve is normally closed to prevent fluid communication through the opening. A needleless connector can be engaged with the valve to open the valve and thereby establish a passageway for fluid communication through the opening.

Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for mixing the components under sterile conditions.

Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for mixing the components under sterile conditions.

Abstract: A pharmaceutical mixing container for storing a liquid having at least two factions which tend to separate during storage. A housing has an inner volume and is closed at one end by a septum arrangement and at another end by a combination sealing and pumping member. The combination sealing and pumping member has an integrally formed outer diaphragm element forming a diaphragm chamber with the inner structure of this element, and a plurality of fluid channels extending through the sealing and pumping element from the diaphragm chamber to the surface facing the inner volume of the container. A driving member assembly is coupled to the diaphragm element to enable this element to be extended and retracted by manipulating the driving element assembly inwardly and outwardly of the container.

Abstract: A unitary syringe assembly including a diluent syringe and a jell syringe stores and enables convenient transport of isolated components required for injection. A valve is placed between the two syringes. Immediately before required injection, the valve is opened and the diluent and jell between the two syringes are thoroughly intermixed. Valve aperture size is selected to provide viscous resistance to the flow of the jell until thorough mixing has occurred to provide the user with a tactile indication of sufficient mixing. Upon complete mixing, a needle is attached and injection occurs.

Abstract: An infusion unit has a flexible container and an open-ended pipe having a first opening in communication with the container and a second opening axially opposite the first. The pipe has smaller and larger diameter portions with the smaller diameter portion located between the second opening and the larger diameter portion. An axially moveable plug is receivable within the smaller diameter portion to seal the second opening of the pipe. An axially moveable engaging member with an end for engaging the plug and a needle at the opposite end for piercing the stopper of a vial. The plug may be pushed by the engaging member from the smaller diameter section to the larger diameter section so as to permit flow through the pipe between the first and second openings to the vial and container.

Abstract: A syringe device having a barrel enclosing a first chamber therein containing coaxially aligned primary and secondary plungers. A connectable mixing and delivery tip encloses a second chamber therein and is connected to the barrel by a coupling. A slidable valve having an aperture therethrough to allow passage of air into and out of the secondchamber is disposed between the two chambers. The primary plunger is slidable out one end of the syringe for the selective application of pressure into the syringe barrel. As the primary plunger is urged down into the syringe barrel, air is forced around the secondary plunger and through the valve aperture into the second chamber wherein the substances contained therein are mixed by turbulent aeration. Continued application of pressure on the primary plunger drives the secondary plunger into the slidable valve to plug the aperture in the valve thereby ceasing the agitation of the contents in the second chamber.

Abstract: A terminal reservoir capping device according to the present invention includes a hollow member having first and second open ends. A first plug seals the first open end such that the plug is inwardly displaceable into the hollow member. A second plug seals the second open end. A chamber is defined by the hollow member and the first and second plugs. A reservoir of disinfecting fluid or therapeutic drug is provided in the chamber. Axially extending from the first end of the hollow member is a mechanism for engaging and advancing the tube connector into the chamber so as to inwardly displace the first plug into the chamber. The plug self-releases and allows dispersal of the reservoir fluid into the tube connector.

Abstract: A suction drainage control system wherein waste-treating material is released into a sealed chamber. The chamber comprises of a cover with a flexible liner sealed to and suspended therefrom. A normally closed reservoir is provided on an underside of the cover for storing the waste-treating material therewithin as long as the reservoir remains closed. An externally operated actuator is provided on the cover for opening the reservoir to release the waste-treating material into the sealed chamber.

Abstract: An assembly of containers is provided for efficient and controlled storage of a reagent and subsequent mixing of the reagent with a reagent diluent. The assembly includes a reagent diluent container and a sealed reagent vial. An adapter assembly includes a coupler having one end mountable to the reagent diluent container and having the opposed end defining a hollow plunger. A retainer ring has one end mountable to the coupler and the opposed end mountable to the reagent vial. The reagent vial is engageable with the coupler in a first position and is advanceable into a second position relative to the adapter assembly such that the hollow plunger thereof displaces the seal of the reagent vial permitting the reagent in the reagent vial to flow through the hollow plunger to mix with a buffer or diluent in the reagent diluent container.

Abstract: An ampoule is disclosed having a stopper slidably mounted therein adjacent the proximal end and a rubber diaphragm secured to the distal end. An aperture barrier is provided in the ampoule between the proximal and distal ends, and has an aperture sealed by a plug. Sterile acidified liquid local anaesthetic is contained in an proximal compartment defined in the ampoule by the barrier and the stopper. Sterile alkaline neutralizing reagent is contained in the distal compartment defined in the ampoule by the barrier and the rubber diaphragm. In use, the ampoule is placed in the barrel of a hypodermic syringe, and is then manually advanced in the barrel toward the distal end of the syringe to cause the proximal end of the hypodermic needle of the syringe, which proximal end extends into the barrel of the syringe, to perforate the rubber diaphragm and communicate with the distal compartment of the ampoule. The distal end of the hypodermic needle is then inserted into the oral tissues of the patient.

Abstract: A hypodermic syringe has an elongated tubular body having a front end adapted to carry a needle, a rear end, and a bypass between the ends. A front partition piston defines with the front end a front compartment adapted to hold a substance and a rear piston defines with the front piston a rear compartment adapted to hold a fluid miscible with the front-compartment substance. The front piston is displaceable into a middle position in the bypass for fluid communication between the compartments. A stem projecting rearward out of the body from the rear piston is provided with axially spaced front and rear external screwthreads and has a clear region between the screwthreads. A damper on the rear end of the body can engage the screwthreads for slowing axial movement of the screwthreads past the rear end of the body and for permitting relatively rapid axial movement of the stem in the body when the clear region is level with the damper.

Abstract: A dual chambered vial is equipt with a dislodgeable stopper device between the two chambers, whereby components of a mixture may be maintained in separate chambers until comingling is desired. The stopper is dislodged by means of a plunger activated by depression of flexible walls of one chamber.

Abstract: A two-compartment syringe having a bypass through which the liquid can be forced into the medicament compartment by advance of the piston connected to the stem, has a brake retarding the displacement of this piston until it reaches the bypass to prevent undesired discharge of the injectable substance from the syringe. Once the latter piston has reached the bypass, the stem can be axially displaced independently of a braking action by the damping means for normal injection.

Abstract: A cartridge 444, 644, 744 having a drug or other beneficial agent 608 therein and including an adapter 477 is positioned on a receptacle 442, 642 within a parenteral fluid administration set 420. Also disclosed is an adapter 477' for connecting the receptacle 442, 642 to a chamber 606 having a beneficial agent therein. The cartridge and adapter permit a single opening through the injection site at the receptacle and at the chamber at opposite ends of the flow path means while still permitting simultaneous flow both into and out of the chamber and the receptacle.

Abstract: A container comprises a bottle for a liquid product and having at the end of its neck a leakproof envelope enclosing an additional product to be stored separately from the liquid in the bottle. A cap on the neck includes a slidable push button carrying a perforator to open the envelope in a central region of the envelope to allow the additional product to mix with the liquid and then to be discharged through an eccentric duct in the cap rather than having to pass through the center of the cap where the perforator is positioned.

Abstract: This invention relates to a device for dosing and mixing of two or more liquids. According to the invention, the liquids are led to a chamber (26) where they are mixed, an outlet (30) from the chamber being closed at the same time. When the chamber (26) has been filled, the outlet (30) is opened while the inlets (21, 22) for the starting liquids are simultaneously closed, and when the chamber (26) has been emptied, the outlet (30) is closed again and the inlet or inlets (21, 22) are opened. This cyclic process is repeated any desired number of times. The chamber has a variable volume, and changes of the volume are sensed by a sensor (28), which controls the opening and closing of the inlets and the outlets.The device for carrying out the method is provided with a mechanical bistable flip-flop device, which in one of its stable positions opens the inlets (21, 22) and closes the outlet (30), and in the other stable position closes the inlets and opens the outlet.

Abstract: The invention relates to a device for preparing and dispensing a solution. A bottle containing a substance to be disolved is closed by a disc-shaped base having a rigid rod thereon and a deformable head. A tube of solvent is closed by an apertured slidable piston. Mixing is effected by placing the piston against the rigid rod and applying axial pressure which dispenses the solvent from the tube, through a capillary channel in the rod and into the bottle. Slots in the rod are revealed during this operation to allow the air to escape from the bottle. The deformable head also serves to pressurize the bottle to permit dispensing therefrom.

Abstract: A three-way valve for automatic sequencing of fluid flow from a syringe into an IV administration set comprises a housing which forms a fluid chamber having a first and a second inlet and an outlet. A sleeve having a fluid passageway normally closed by a check valve is slidably disposed within the fluid chamber for reciprocal movement between a first position and a second position for respective fluid sealing engagement with the first and second inlets. With the sleeve in the second position, fluid flows through the chamber from the first inlet to the outlet. Engagement of a syringe with the second inlet urges the sleeve into the first position to permit fluid flow from the syringe into the second inlet and through the chamber to the outlet. Upon emptying of the syringe, the syringe plunger seals the second inlet and urges against a probe that opens the check valve to permit resumption of fluid flow from the first inlet to the outlet.

Abstract: A container housing liquid medication is provided together with a syringe and a coupling member for use in orally administering the medication to a patient. The coupling member is fastened to the container and includes a head member projecting upwardly to receive an inner tip of the syringe barrel. The liquid medication is dispensed from the container into a barrel of the syringe through a bore of the head member when a plunger is moved within the syringe barrel. After a predetermined amount of medication is received by the syringe barrel, the syringe barrel is removed from the head member and the predetermined amount of medication is administered orally to the patient. A cap member attached to the coupling member by means of a strap closes off the bore so that no medication escapes from the container when the syringe is disconnected from the head member.