Solid Dissolved In Liquid Patents (Class 604/92)
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Patent number: 7938816Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.Type: GrantFiled: April 8, 2010Date of Patent: May 10, 2011Assignee: Laboratoire AguettantInventor: Pierre Frezza
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Patent number: 7927618Abstract: This invention relates to kits for the preparation of a composition, which comprises a carrier phase that forms an implant or particles in the body, on the body or under physiological conditions. The carrier phase comprises at least one solid carrier material and a solvent, wherein the carrier material and the solvent are stored separately in the kit. The kit can also include an additional liquid phase to aid in forming the particles. An active compound included in the carrier phase is generally released in an extended manner. This invention also relates to compositions prepared from this kit and to methods for the preparation of the kits and the composition.Type: GrantFiled: July 10, 2002Date of Patent: April 19, 2011Assignee: Laboratorios Farmacéuticos Rovi S.A.Inventor: Roland Bodmeier
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Publication number: 20110086010Abstract: Methods and devices for the preparation of a biological pharmaceutical composition outside of a classified environment, such as Biological Safety Cabinet type environment, are described. In one aspect of the present technology, a method is provided to prepare a biological pharmaceutical composition preferably in an area next to a patient's bedside or at a facility's pharmacy. The method comprises transferring an appropriate amount of a diluent from a diluent component (645) into a mixing receptacle (605) using a transfer device (620), connecting a pooling (630) harness between a biological pharmaceutical component (640) and the mixing receptacle, transferring a biological pharmaceutical composition through the pooling harness to the mixing receptacle, mixing the diluent and the biological pharmaceutical composition to form a biological pharmaceutical composition mixture and administering the biological pharmaceutical composition mixture to a patient for either flat based or weight based dosing needs.Type: ApplicationFiled: April 23, 2008Publication date: April 14, 2011Inventors: Robert E. Newman, Roman M. Salasznyk
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Publication number: 20110015568Abstract: The present disclosure relates to an apparatus and method for combining a solid particulate with a solvent prior to an injection protocol within an injector device. The solid particulate may be a pharmaceutical compound and the microcapsules contain a solvent for such particulate. Upon application of pressure, the microcapsules may be configured to burst and release the solvent, thereby dispersing and/or partially dissolving the particulate. The injector therefore allows for the use of relatively unstable pharmaceutically active compounds in a device that requires relatively long storage times and the use of pharmaceutical compounds that are relatively stable in the dry state.Type: ApplicationFiled: July 14, 2009Publication date: January 20, 2011Applicant: Southwest Research InstituteInventors: Joseph T. PERSYN, Joseph A. MCDONOUGH, James D. OXLEY
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Patent number: 7862537Abstract: Medical device for in situ liquid drug reconstitution in medicinal vessels containing drug contents. The medical device includes a body member having a vessel port for insertion into a medicinal vessel containing drug contents, and a syringe port for receiving a syringe containing a diluent for reconstituting the drug contents into a reconstituted liquid drug. The medical device includes a one-way flow restriction mechanism between the two ports for positively restricting injection of diluent into a medicinal vessel and only slightly restricting aspiration of reconstituted liquid drug therefrom, if at all.Type: GrantFiled: February 13, 2006Date of Patent: January 4, 2011Assignee: Medimop Medical Projects Ltd.Inventors: Freddy Zinger, Igor Denenburg
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Publication number: 20100286603Abstract: A kit and method for preparing a Degarelix solution for administration to a patient. The kit includes a first chamber containing lyophilised Degarelix, a second chamber containing water, a syringe for transferring the water from the first chamber to the second chamber, at least one of a hypodermic needle, a safety needle device, or a needleless device for delivery of the Degarelix to the patient, and a mixing apparatus. The mixing apparatus is configured to receive the first chamber to mix the Degarelix and water to produce a Degarelix solution suitable for deliver to a patient. The method includes transferring a volume of water from a first chamber into a second chamber containing lyophilised Degarelix, connecting the second chamber to a mixing apparatus and mixing the water and lyophilised Degarelix for a period of time.Type: ApplicationFiled: May 5, 2010Publication date: November 11, 2010Inventor: Carin WINDERSTRĂ–M
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Publication number: 20100286606Abstract: The present invention discloses a device for automatically mixing powder for injection, comprising an injector body, a solvent bottle, a needle, a first impelling unit and a second impelling unit, said injector body has a solute bottle and its mouth is opposite the mouth of said solvent bottle, said first impelling unit is disposed upon said solvent bottle for driving said solvent slide along said solute bottle; said second impelling unit is sleeved with a needle and locate between said mouth of solute bottle and mouth of solvent bottle, further comprising a first and a second impelling sleeve; wherein said first and second impelling sleeve are driven by said solvent bottle to slide along said solute bottle, so the first end of said needle is fixed and extend through said solute bottle, said solvent bottle further drive said first impelling sleeve and said second impelling sleeve to turn with each other, finally said second impelling sleeve slide opposite said first impelling sleeve to make the second end ofType: ApplicationFiled: February 2, 2008Publication date: November 11, 2010Inventor: Yuying Ding
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Patent number: 7815598Abstract: An injection device for use with a two-chamber ampoule, wherein the device includes a front casing part with which the two-chamber ampoule can be associated, a rear casing part, a threaded drive accommodated by the rear casing part, a piston rod which, during a blending movement, is moved by the threaded drive toward a dispensing end of the device and slaves at least a closing piston of the two-chamber ampoule in the process, wherein a spring element presses the piston rod toward the dispensing end during a delivery movement.Type: GrantFiled: September 1, 2005Date of Patent: October 19, 2010Assignee: TecPharma Licensing AGInventors: Edgar Hommann, Benjamin Scherer, Ian Thompson
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Patent number: 7793655Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.Type: GrantFiled: July 11, 2005Date of Patent: September 14, 2010Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventor: Dieter Hochrainer
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Patent number: 7722594Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.Type: GrantFiled: June 2, 2005Date of Patent: May 25, 2010Assignee: Laboratoire AguettantInventor: Pierre Frezza
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Publication number: 20100106139Abstract: A syringe-carpule assembly comprising first and second carpules, a housing holding the first and second carpules in an end-to-end relationship, an outer hollow plunger rod supported by and slidable relative to the housing, and an inner hollow rod having first and second openings and being slidably arranged inside the outer hollow plunger rod. The inner hollow rod is slidable between first and second positions. The inner hollow rod in the first position has the first opening disposed within the first carpule and the second opening disposed within the second carpule. This allows liquid solvent in the second carpule to flow into the first carpule, which comprises an evacuated chamber containing solid matter that dissolves in the presence of that solvent to form a mixture. The second carpule is then removed and the mixture in the first carpule is injected into the patient.Type: ApplicationFiled: October 28, 2009Publication date: April 29, 2010Inventor: Steven Schulhof
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Publication number: 20100087799Abstract: An administering device for administering an active substance from a multi-chamber container comprising a first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance, wherein the administering device comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device, the container being moveable relative to the housing, and the administering device further comprising a first indicator for indicating a position of the container relative to the housing upon completion of a mixing step, and a second indicator for indicating a position of the container relative to the housing upon completion of a venting step.Type: ApplicationFiled: October 2, 2009Publication date: April 8, 2010Inventors: Sofia Galbraith, Ulrich Moser, Juerg Hirschel, Ian Thompson
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Publication number: 20090318361Abstract: An anti-hemorrhage medication pack for administering an anti-hemorrhage drug, in particular for the treatment of hemorrhage caused by trauma in emergency situations comprises an active ingredient selected from the group comprising the 1-24 amino acid sequence of the adrenocorticotropic hormone (ACTH 1-24) and all its fragments and analogues, and analogues of fragments, with agonist activity on the MC4 melanocortin receptors, and all the synthesis agonists, including those with a nonpeptidic structure, of the MC4 melanocortin receptors. An auto-injector (1; 11) includes the drug for automatically injecting a patient with the drug.Type: ApplicationFiled: July 6, 2007Publication date: December 24, 2009Inventors: Giorgio Noera, Alfio Bertolini
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Patent number: 7597680Abstract: A syringe device and a method of preparing medicine using the device capable of easily and accurately performing operations for mixing and dissolving a lyophilized product into a dissolution liquid before use. A double ended needle assembly and an intermediate holder are fitted to the first cylindrical part of a connection holder, a first syringe in which the dissolution liquid is stored is inserted into the first cylindrical part through the intermediate holder, and a second syringe in which the lyophilized product is stored in a depressurized state is fixedly inserted into the second cylindrical part of the connection holder. First, the intermediate holder is locked by a finger hooking projected piece, the first syringe is pushed into the intermediate holder in the locked state of the double ended needle assembly at an initial position by locking ribs, and the first syringe is unsealed by one end of the double ended needle.Type: GrantFiled: February 8, 2006Date of Patent: October 6, 2009Assignee: Kaken Pharmaceutical Co., Ltd.Inventors: Norio Watanabe, Yasuhiko Sato, Kouichi Sugita, Katsuya Taguchi
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Publication number: 20090221987Abstract: The present invention is generally directed to a system and method for cleansing mucus and in particular, removing mucus from the nasal cavity, mouth, and throat. The sinus and throat cleansing kit includes packets of dry saline, packets of dry salt, a spoon for mixing the dry saline and dry salt with water to produce a saline solution and salt solution, a pot for pouring the saline solution into a nostril of the user cleansing a nasal cavity of mucus, a container lid for pouring the salt solution into the mouth of the user cleansing a mouth and throat of mucus, and a container for collecting saline solution, salt solution, and mucus. The sinus and throat cleansing kit provides a clean and portable way to remove mucus, bacteria, and other viruses of the throat.Type: ApplicationFiled: February 29, 2008Publication date: September 3, 2009Inventor: Syeda J.Z. Mansur
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Publication number: 20080306436Abstract: Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.Type: ApplicationFiled: February 1, 2006Publication date: December 11, 2008Inventors: Evan T. Edwards, Eric S. Edwards, Mark J. Licata
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Publication number: 20080287864Abstract: A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5-250 microns and generally about 50-100 microns.Type: ApplicationFiled: July 30, 2008Publication date: November 20, 2008Inventor: Zeil B. Rosenberg
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Patent number: 7404820Abstract: Medical devices for filtering fluids flowing through a lumen and a method of forming medical devices. The devices can be used in vascular channels, urinary tracts, biliary ducts and the like, and filter emboli and other debris generated at a treatment site.Type: GrantFiled: April 4, 2005Date of Patent: July 29, 2008Assignee: ev3 Inc.Inventors: Rudy Mazzocchi, Timothy Claude, James Segermark
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Publication number: 20080177226Abstract: A syringe device and a method of preparing medicine using the device capable of easily and accurately performing operations for mixing and dissolving a lyophilized product into a dissolution liquid before use. A double ended needle assembly and an intermediate holder are fitted to the first cylindrical part of a connection holder, a first syringe in which the dissolution liquid is stored is inserted into the first cylindrical part through the intermediate holder, and a second syringe in which the lyophilized product is stored in a depressurized state is fixedly inserted into the second cylindrical part of the connection holder. First, the intermediate holder is locked by a finger hooking projected piece, the first syringe is pushed into the intermediate holder in the locked state of the double ended needle assembly at an initial position by locking ribs, and the first syringe is unsealed by one end of the double ended needle.Type: ApplicationFiled: February 8, 2006Publication date: July 24, 2008Applicant: Kaken Pharmaceutical Co., Ltd.Inventors: Norio Watanabe, Yasuhiko Sato, Kouichi Sugita, Katsuya Taguchi
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Patent number: 7396341Abstract: A locking-stressing-mechanism with spring-actuated output drive and a counter with which an apparatus of this kind is fitted, accommodated in a two part housing the two parts of which are mounted to be rotatable relative to each other, can be blocked by means of a pre-stressed leaf spring. The leaf spring is initially accommodated in a recess in the wall of one housing part. As soon as the permitted number of actuations has been reached a push rod pushes the leaf spring out of its resting position. The leaf spring then jumps into a recess in the wall of the other housing part and the two housing parts can no longer be rotated relative to each other. The push rod may be mounted on the pointer of the counter. This blocking device can only be overcome by the application of a force which is sufficient to destroy the device. The device is suitable for blocking a high pressure atomiser or a needleless injector with which a fluid is atomised to form an aerosol or a fluid is injected into a biological tissue.Type: GrantFiled: August 27, 2003Date of Patent: July 8, 2008Assignee: Boehringer Ingelheim International GmbHInventors: Michael Schyra, Herbert Wachtel
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Patent number: 6878338Abstract: A reagent dissolution device and methods of using the same, wherein the device comprises a housing (40), a diluent (25), and at least one reagent bed (35), wherein the diluent (25) and the at least one reagent bed (35) are separated by a friable barrier (50) and a flow distribution disk (100). Alternate embodiments include chambers with a plurality of reagent beds as well as chambers for the mixing of two or more liquid reagents.Type: GrantFiled: May 6, 2002Date of Patent: April 12, 2005Assignee: Prismedical CorporationInventors: Michael A. Taylor, Carolyn Fitzgerald
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Patent number: 6817987Abstract: A syringe holding a solvent and a soluble component has a tubular body formed its front and rear ends with a bypass, a plunger axially slidable in the body, and a stem projecting axially rearward out of the body from the plunger. A cover fits over the front end of the body and is so tight that the front compartment can be pressurized to a superatmospheric pressure without leakage out the front end. A free piston slidable in the body forward of the plunger subdivides the body forward of the plunger into a front compartment at the front body end holding the soluble component and a rear compartment between the plunger and the piston and holding the solvent. Stops are provided for arresting the free piston when it is level with the bypass in a position permitting flow through the bypass between the compartments.Type: GrantFiled: August 16, 2002Date of Patent: November 16, 2004Assignee: Arzneimittel GmbH Apotheker Vetter & Co. RavensburgInventors: Udo J. Vetter, Thomas Otto
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Patent number: 6793646Abstract: A pen-style injector (20) includes an automated mover (70) that completes a combination of two substances such as a reconstitution process to reconstitute a lyophilized medicament prior to making an injection. The automated mover (70) is preloaded selectively released to automatically reconstitute the medicament at a controlled rate. The illustrated embodiment includes a mechanical spring (70) that provides the necessary movement of components within the injector (20) to complete the automated reconstitution process. The injector also has safety features (100) to prevent an injection prior to completing the automated combination of the substances.Type: GrantFiled: January 18, 2002Date of Patent: September 21, 2004Assignee: Becton Dickinson and CompanyInventors: Lucio Giambattista, David DeSalvo
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Patent number: 6719719Abstract: A spike for facilitating the introduction of liquid under pressure into a container containing a substance is provided which includes an elongate spike shaft having a spike side wall, a longitudinal axis, a distal end and a proximally located end portion, where the distal end has a sharp, pointed tip. An introduction channel is located within the spike shaft for receiving liquid into the container where a portion of the introduction channel is angled to cause liquid to travel out of the introduction channel in a direction non-parallel to the longitudinal axis of the spike shaft. An extraction channel may be included within the spike shaft for removing liquid from the container, where the extraction channel extends through the elongate spike shaft towards the proximally located end portion.Type: GrantFiled: May 23, 2001Date of Patent: April 13, 2004Assignee: Elan Pharma International LimitedInventors: Ehoud Carmel, Gilad Lavi, Gil Yigal, Izrail Tsals
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Patent number: 6702778Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a dry compartment located within a housing for storing a predetermined dry charge of the medicament therein, a wet compartment within the housing for storing a predetermined amount of liquid injection solution therein, an activation assembly for causing the liquid injection solution in the wet compartment to be transferred to the dry wet compartment, and at least one compression assembly for maintaining the medicament located in the dry compartment under a continuous compressive state as the liquid injection solution passes through the dry compartment.Type: GrantFiled: June 8, 2001Date of Patent: March 9, 2004Assignee: Meridian Medical Technologies, Inc.Inventors: Robert Leavitt Hill, Maria Cristina D'Erasmo, John G. Wilmot, Gerald L. Wannarka
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Publication number: 20040015128Abstract: A microinjection system comprises a device for housing dried forms of medical reagents, such as vaccines, hormones, etc. in single doses. Within a single chamber, a dry reagent bed is provided adjacent a compression component that keeps the bed compacted. In operation, diluent flows through the chamber to carry the reagent out of the chamber in fluid form. In the illustrated embodiments, the fluid carrying reagent is directly delivered from the chamber via a needle. Integral or connectable diluent delivery devices are disclosed for providing an appropriate volume of diluent to the reagent chamber. Unstable formulations of drugs, for example, can be safely stored in dry form. When injection is needed, the drug can be delivered almost instantly in fluid form simply by releasing diluent through the chamber, where the reagent bed is dissolved or suspended while the remaining reagent is continually compacted.Type: ApplicationFiled: May 12, 2003Publication date: January 22, 2004Inventor: Michael A. Taylor
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Publication number: 20030036724Abstract: A syringe holding a solvent and a soluble component has a tubular body formed its front and rear ends with a bypass, a plunger axially slidable in the body, and a stem projecting axially rearward out of the body from the plunger. A cover fits over the front end of the body and is so tight that the front compartment can be pressurized to a superatmospheric pressure without leakage out the front end. A free piston slidable in the body forward of the plunger subdivides the body forward of the plunger into a front compartment at the front body end holding the soluble component and a rear compartment between the plunger and the piston and holding the solvent. Stops are provided for arresting the free piston when it is level with the bypass in a position permitting flow through the bypass between the compartments.Type: ApplicationFiled: August 16, 2002Publication date: February 20, 2003Inventors: Udo J. Vetter, Thomas Otto
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Patent number: 6481435Abstract: The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance concentrate in which the active substance is present as a solution or suspension for storage purposes.Type: GrantFiled: May 31, 2001Date of Patent: November 19, 2002Assignee: Boehringer Ingelheim Pharma KGInventors: Dieter Hochrainer, Bernd Zierenberg
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Patent number: 6419656Abstract: A medical syringe has a tubular body extending along an axis and having a front end and a rear end, a plunger axially slidable in the body and carrying a stem projecting axially rearward out of the body from the plunger, and a free piston slidable in the body forward of the plunger and subdividing the body forward of the plunger into a front compartment at the front body end and a rear compartment between the plunger and the piston. The body is formed with a bypass passage forward of the piston in a starting position so the front compartment can hold a soluble medicament and the rear compartment can hold its solvent. Structure at the rear body end forms a radially inwardly open angularly limited cutout and at least two axially spaced, angularly offset, and radially outwardly projecting stop bumps on the stem are axially displaceable through the cutout in respective angularly offset positions of the stem.Type: GrantFiled: March 20, 2000Date of Patent: July 16, 2002Assignee: Arzneimittel GmbH Apotheker Vetter & RavensburgInventors: Udo J. Vetter, Klaus Schönwetter
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Patent number: 6374876Abstract: A cassette is described including a housing, an inner reservoir located within the housing, a valve coupled to the inner reservoir and coupled to the housing, and a delivery conduit coupled to the inner reservoir and emerging from the delivery opening of the cassette. The cassette also includes a dispensing apparatus that defines a passage and has a first activating device that opens the valve of the cassette. The dispensing apparatus also has a second activating member capable of establishing fluid communication with a medicant container. A method of mixing a powdered drug and a liquid includes establishing fluid communication between the reservoir and the medicant container, dispensing at least a portion of the liquid into the medicant container, and transferring the mixed drug into the reservoir.Type: GrantFiled: March 15, 2001Date of Patent: April 23, 2002Assignee: Deltec, Inc.Inventor: Gail Bynum
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Publication number: 20020042592Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, an activation assembly and a needle assembly for dispensing a dissolved medicament to a user. A dry compartment for storing a predetermined dry charge of dry medicament is located within the interior chamber. A wet compartment for storing a predetermined amount of liquid injection solution is also located within the interior chamber. A separation assembly separates the dry compartment from the wet compartment. The separation assembly prevents transfer of the liquid injection solution from the wet compartment to the dry compartment prior to activation of the automatic injection device. One or more medicament support assemblies located within the dry compartment prevent the passage of undissolved medicament from the dry compartment.Type: ApplicationFiled: October 9, 2001Publication date: April 11, 2002Inventors: John G. Wilmot, Robert L. Hill, John Whittier
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Patent number: 6339718Abstract: A fluid injection arrangement, in the context of patient imaging systems, in which phases of contrast medium injection and flushing medium injection can be freely and selectably ordered so as to make available to the operator and patient a vast array of possible protocols that has hitherto been essentially unattainable. Also contemplated is the use of a “hold” phase, involving an indefinite pause between phases of a protocol, in connection with such imaging systems. Further contemplated is the use of a “pause” phase in which a pause of fixed duration is pre-programmed into the protocols of MRI injector systems.Type: GrantFiled: July 30, 1999Date of Patent: January 15, 2002Assignee: Medrad, Inc.Inventors: Doug Zatezalo, Jeffrey John Thompson, Steven C. Rygg, Scott R. Griffith, John Gardner, Ronald Barbati
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Patent number: 6267154Abstract: A container for holding a concentrated drug for a mixing system includes a barrel with a cover structure including a delivery passage at a first end and a closing structure at an opposite, second end. A female Luer lock fitting defines the delivery passage at the first end. The closing structure and the female Luer lock fitting can each be formed integrally with the barrel, or the closing structure can be a slidable stopper. The closing structure may also include a holder. The holder is constructed to move between two positions. In the first position, the holder is in a elevated position on the second end of the barrel. The barrel can vent vapor around the cover piece. In the second position, the holder is depressed onto the barrel and it cannot vent vapor. The cover structure may include a snap-on cover piece to fit over the first end. The cover piece includes the female luer lock fitting. The cover piece functions similar to the holder.Type: GrantFiled: June 5, 1998Date of Patent: July 31, 2001Assignee: Abbott LaboratoriesInventors: Robert Felicelli, Richard W. Grabenkort, Con A. Lasaitis, Gary N. Smith, John S. Ziegler
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Patent number: 6033377Abstract: In an ampoule for a medicament the space accommodating the medicament is defined by an ampoule wall (1) a pierceable seal (5) closing one end of the ampoule and a piston (7) closing the other end of the ampoule. A metal containing fixation element (8) is secured to one of the parts defining the medicament accommodating space. A mixing element (9, 10) also containing a metal and having a density larger than 1,0 g/cm.sup.3 is movable in medicament accommodating space. At least one of the elements, the fixation element (8) and the mixing element (9, 10), can be attracted by a magnet, and at least one of these elements is a magnetic element, the magnetic strength being so that the mixing element (9, 10) can during normal handling of the ampoule be fixed relative to this ampoule by the magnetic attraction between the fixation element (8) and the mixing element (9, 10) but may be released from its fixed position by manual operation.Type: GrantFiled: February 3, 1998Date of Patent: March 7, 2000Assignee: Novo Nordisk A/SInventors: Thomas Buch Rasmussen, Patric Jannasch, Erling Bonne J.o slashed.rgensen
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Patent number: 5941867Abstract: Sterile solutions containing pharmaceuticals suitable for use in low and micro-gravity environments are prepared with unit dose pharmaceutical dispensers having a pre-measured quantity of medicament. A compressed air reservoir may be activated to rupture the dispenser and positively expel the unit dose into solution. This can be accomplished by inverting a bag containing the pharmaceutical or by operation of a piston which pushes all the pharmaceutical from the dispenser. A robot either places the pharmaceutical dispensers inside a mixing chamber or connects the dispensers to the mixing chamber, which comprises a flexible bag expandable to receive sterile water and pharmaceuticals. The mixing chamber may collapse under cabin pressure to drive prepared solutions from the chamber through a sterilization filter into an intravenous bag or dispensing unit.Type: GrantFiled: May 8, 1998Date of Patent: August 24, 1999Inventor: Ti Kao
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Patent number: 5766149Abstract: An apparatus for separately storing a medicament component, such as a drug and for mixing this component with a liquid component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the liquid component. The device includes a novel collapsible vial structure which can be used for controllably introducing a support structure carrying the medicament component into the liquid container whereby the medicament and liquid components will thoroughly mix under sterile conditions.Type: GrantFiled: February 23, 1996Date of Patent: June 16, 1998Inventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5766147Abstract: A device is disclosed which provides for direct incorporation of a substance from a separate container, such as a drug vial, into the contents of a liquid delivery device, which has a connecter to provide communication between the device and the container, and means for closing the connection prior to dispensing the contents of the device. A method for permitting a substance in a container to be transferred to a liquid delivery device, and contents of the device to be administered to a patient is also disclosed.Type: GrantFiled: June 7, 1995Date of Patent: June 16, 1998Assignee: Winfield MedicalInventors: Gregory E. Sancoff, Mark C. Doyle, Frederic P. Field
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Patent number: 5510115Abstract: An anhydrous solid water-soluble composition and method for direct controlled administration of beneficial agents to a flowing medical fluid. The beneficial agents are geometrically dispersed in a solid matrix and isolated from one and other to allow administration of mutually reactive agents.Type: GrantFiled: December 8, 1994Date of Patent: April 23, 1996Assignee: Baxter Travenol Laboratories, Inc.Inventors: Julian P. Breillatt, Jr., Lecon Woo, Deanna J. Nelson, Richard Appl, Naomi L. Weinless, Sharon Pokropinski, Paul Soltys, Sumner A. Barenberg
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Patent number: 5484410Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for controllably ejecting the first component from the glass vial so that it will fall by force of gravity into the second container whereby the first and second components will thoroughly mix under sterile conditions.Type: GrantFiled: December 22, 1994Date of Patent: January 16, 1996Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5478311Abstract: A pill crushing/dispensing device includes a plunger having a handle at one end and an abraded surface at the other, and a barrel/spoon unit which has an opposing abraded surface in its bottom interior so that a pill is crushed between the abraded surfaces as the plunger is advanced into the barrel. After the pill is crushed between the abraded surfaces, the plunger is removed and a fluid added to create a suspension of pill crushings which may then be orally administered by tipping the barrel/spoon unit to a generally horizontal position so that the fluid flows into the spoon unit which may then itself be inserted into a patient's mouth. In alternative embodiments, a central air passageway extends the length of the plunger unit to facilitate the flow of air to and from an air pocket between the abraded surfaces to facilitate the easy movement of the plunger within the closed barrel. A cap may be used to selectively seal the passageway.Type: GrantFiled: June 23, 1994Date of Patent: December 26, 1995Inventor: Jeffrey D. Klearman
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Patent number: 5472421Abstract: A pill crushing syringe is disclosed which includes a barrel and a plunger, with abraded surfaces on each so that a pill placed in the barrel is crushed as the plunger advances within the barrel. The barrel has an aperture located near the closed end with a catheter connected around and extending from the aperture. The plunger has a sealing gland to provide an airtight seal with the barrel so that liquid may be drawn into the barrel through the aperture by withdrawing the plunger from the barrel to thereby suspend the crushed pill in the liquid, and the suspension may be flushed from the barrel by thereafter advancing the plunger into the barrel. In an alternative embodiment, a bi-level barrel has an aperture in spaced relation to the closed end forming a pocket wherein the crushed pill ingredients accumulate. The pocket at the closed end and the separation between the aperture and the barrel closed end helps prevent the medication from escaping the barrel via the catheter prior to aspiration.Type: GrantFiled: December 13, 1994Date of Patent: December 5, 1995Assignee: Lake Medical Products, Inc.Inventors: Jeffrey D. Klearman, Matt Roth, Jerry Roth, Robert Bronson
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Patent number: 5464393Abstract: A pill crushing syringe is disclosed which includes a barrel and a plunger, with abraded surfaces on each so that a pill placed in the barrel is crushed as the plunger advances within the barrel. The barrel has an aperture located near the closed end with a catheter connected around and extending from the aperture. The plunger has a sealing gland to provide an airtight seal with the barrel so that liquid may be drawn into the barrel through the aperture by withdrawing the plunger from the barrel to thereby suspend the crushed pill in the liquid, and the suspension may be flushed from the barrel by thereafter advancing the plunger into the barrel. In an alternative embodiment, a bi-level barrel has an aperture in spaced relation to the closed end forming a pocket wherein the crushed pill ingredients accumulate. The pocket at the closed end and the separation between the aperture and the barrel closed end helps prevent the medication from escaping the barrel via the catheter prior to aspiration.Type: GrantFiled: June 23, 1994Date of Patent: November 7, 1995Assignee: Lake Medical Products, Inc.Inventors: Jeffrey D. Klearman, Jeffrey J. Bierman, Eli Schachet
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Patent number: 5454786Abstract: A cartridge assembly for holding a lyophilized product, forming a disposable portion of a pen injector includes a cylindrical glass cartridge adapted to receive the product, a closure cap, a cartridge case, and a plunger mechanism. The closure cap is adapted to retain an elastomeric disc seal during lyophilization and includes diametrically opposed ledges. The closure cap and seal are adapted to cover a neck portion of the ampule, the neck portion having on its end a radially extending circumferential flange. The ledges of the closure cap and the flange of the neck portion allow the closure cap to remain open during lyophilization, oxygen purge and nitrogen overlay. An oval-shaped indentation formed on the inside of the closure cap aids in snapping the closure cap about the flange without crimping to retain the closure cap underneath the flange.Type: GrantFiled: March 28, 1994Date of Patent: October 3, 1995Assignee: Eli Lilly and CompanyInventor: Dale C. Harris
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Patent number: 5425705Abstract: The invention provides devices and methods for thoracoscopically arresting the heart and establishing cardiopulmonary bypass, thus facilitating a variety of less-invasive surgical procedures on and within the heart and great vessels of the thorax. In one embodiment, the invention provides a thoracoscopic system for arresting a patient's heart including a clamp configured for introduction into the patient's thoracic cavity through a percutaneous intercostal penetration in the patient's chest. The clamp is positionable about the patient's ascending aorta between the coronary arteries and the brachiocephalic artery. The clamp is coupled to the distal end of an elongated handle means for manipulating the clamp from a location outside of the patient's thoracic cavity. A means for actuating the clamp is coupled to the proximal end of the handle means. When actuated, the clamp blocks blood flow through the ascending aorta.Type: GrantFiled: December 27, 1993Date of Patent: June 20, 1995Assignee: Stanford Surgical Technologies, Inc.Inventors: Philip C. Evard, Timothy R. Machold, Hanson S. Gifford, III, Alex T. Roth, Wesley D. Sterman, Lawrence C. Siegel, Jeffry J. Grainger
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Patent number: 5405343Abstract: The invention is directed to a blood bag system for blood products comprising a bag (3) and at least one tubing (11) connected thereto, the system being made of at least partly transparent plastics material, wherein photoactive substances (31) may be enclosed in a closed-off section (A) of the tubing (11) of the ready-for-use system, which may be handled individually as an independent unit. Every blood bag system of this kind is adapted to be combined with another blood bag system, which may comprise one or several bags (3, 5, 7, 9) and may likewise be handled as an independent unit, by interconnecting both systems.Type: GrantFiled: September 2, 1993Date of Patent: April 11, 1995Assignee: Blutspendedienst der Landesverbande des Deutschen Roten Kreuzes Niedersachsen, Oldenburg und Bremen G GmbHInventor: Harald Mohr
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Patent number: 5380315Abstract: An apparatus is provided for separately storing and selectively mixing a first component, which is in a liquid form, and a second component. The apparatus is formed of a first container made of a flexible material, having a communication mouth with an isolator and adapted to store the first component therein, a supporting case connected to the communication mouth, a second container having a mouth portion held in the case and a plug fitted in the mouth portion and adapted to store the second component, and a hollow, inflexible communication device capable of penetrating through the isolator and the plug. The communication device is accommodated in the first container and is attached to the communication mouth movably therein.Type: GrantFiled: January 26, 1993Date of Patent: January 10, 1995Assignee: Material Engineering Technology Laboratory IncorporatedInventors: Keinosuke Isono, Tatsuo Suzuki
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Patent number: 5376072Abstract: A pill crushing syringe includes a barrel and a plunger, with abraded surfaces on each so that a pill placed in the barrel is crushed as the plunger advances within the barrel. The barrel has an aperture located near the closed end with a catheter connected around and extending from the aperture. The plunger has a sealing gland to provide an airtight seal with the barrel so that liquid may be drawn into the barrel through the aperture by withdrawing the plunger from the barrel to thereby suspend the crushed pill in the liquid, and the suspension may be flushed from the barrel by thereafter advancing the plunger into the barrel.Type: GrantFiled: December 15, 1993Date of Patent: December 27, 1994Assignee: Lake Medical Products, Inc.Inventors: Jeffrey D. Klearman, Jeffrey J. Bierman, Eli Schachet
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Patent number: 5342346Abstract: A fluid container comprises a drug container, a deformable solvent container, a double-pointed hollow needle having a sharp piercing edge at each end and being arranged between the drug container and the solvent container, a guide capsule with a cap rotatably mounted thereon, and a means for converting rotary motion of the cap to a linear motion of the drug container to push the drug container toward the solvent container in cooperation with the cap and the guide capsule so that a fluid communication is made between two containers through the needle.Type: GrantFiled: April 9, 1993Date of Patent: August 30, 1994Assignee: Nissho CorporationInventors: Minoru Honda, Masanobu Iwasa, Tetuzi Miyamoto, Koji Ikeda, Toshihiro Kikuchi
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Patent number: 5318524Abstract: The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.Type: GrantFiled: March 2, 1992Date of Patent: June 7, 1994Assignee: CryoLife, Inc.Inventors: Brenda S. Morse, A. Denise Turner, Robert T. McNally
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Patent number: 5312336Abstract: A two component mixing syringe for mixing and then self-administering a pharmaceutical by injection. A first liquid component is contained within an annular volume between a pair of coaxial housings. A pair of sealing bands defines the upper and lower boundaries of the annular volume. The lower sealing band is located above an aperture communicating with the inner housing interior. A driving sleeve is mounted with a driving end resting on the upper sealing band, the sleeve being located in the annular space between the two housings. Downward motion of the sleeve forces the upper sealing band downwardly causing the liquid component to drive the lower seal downwards past the cross bore. Thereafter, the liquid is free to flow through the cross bore and mix with the second component in the interior of the inner housing element.Type: GrantFiled: April 14, 1993Date of Patent: May 17, 1994Assignee: Habley Medical Technology CorporationInventors: Terry M. Haber, William H. Smedley, Clark B. Foster