Abstract: Improved/efficient fiber laser systems are provided for medical/cosmetic applications, comprising at least one pump source, optically coupled with at least one fiber laser. The fiber laser comprises an irregularly-shaped single-, double- or multiple-clad fiber of unconventional structure and geometry, and means for partially/completely reflecting the pump radiation, such as Bragg gratings. The fiber laser system further comprises at least one fiber optic delivery device optically coupled with the pump source, with the irregularly-shaped single-, double- or multiple-clad fiber laser, or with both, to convey laser radiation to a treatment site. The fiber optic delivery device comprises one or more waveguides, preferably optical fibers. The irregularly-shaped fiber laser and waveguides of the fiber optic delivery device have the same or different tip configurations to perform the treatment according to therapeutic needs.

Abstract: Embodiments of the present invention provide a laser surgical system with a basic set of functionality which is remotely controllable to implement an advanced set of functionality. According to one embodiment of the present invention, a basic laser surgical system may be coupled to an advanced control unit such that the basic laser surgical system may be controllable by the advanced control unit to implement a broader set of functionality. By moving less frequently used functionality to an advanced unit, the basic unit may be streamlined with regards to both cost and size, and the learning curve required to utilize the basic unit may be reduced relative to a more feature-ladened unit, allowing the basic unit to be utilized in myriad situations or procedures where an “all-in-one” unit would be less than desirable.

Abstract: An ophthalmic laser treatment apparatus comprises: a laser source that emits a laser beam for treatment of an affected part of a patient's eye; an optical fiber that transmits the laser beam emitted from the laser source; and a delivery optical system that irradiates the laser beam emitted from the optical fiber to the affected part of the patient's eye, the delivery optical system including: a plurality of diffraction optical elements each being configured to shape a beam profile of the laser beam at an emission end face of the optical fiber into a beam profile having one of a uniform intensity and a lower intensity in the center than on the periphery on the affected part and also to shape the laser beam to have a different spot size on the affected part of the patient's eye; and a changing unit which selectively disposing one of the diffraction optical elements on an optical path.

Abstract: The present invention provides methods and compositions for regulating transgene expression in a subject using heat generated by electro-magnetic radiation in a target cell. The heat is generated by a thermo generator resided in the target cell upon application the electromagnetic radiation. The amount of the heat is controlled by the energy delivered by the electromagnetic radiation.

Abstract: Devices to perform femtolaser ablation and phacoemulsification are physically and/or operationally combined. In some embodiments the femtolaser ablation and phacoemulsification are housed together, and in other embodiments they are housed separately, but operated through a common display screen. At least some software can be shared by the femtolaser ablation and phacoemulsification functionalities. A non-transitory computer-readable memory can provide data that can be used to operate each of at least one femtolaser ablation functionality and at least one phacoemulsification functionality.

Abstract: Systems and methods for treating tissue by concentrating a laser emission to at least one depth at a fluence sufficient to create an ablation volume in at least a portion of the target tissue and controlling pulse width within the picosecond regime to provide a desired mechanical pressure in the form of shock waves and/or pressure waves.

Abstract: A laser can produce pulses of light energy to eject a volume of the tissue, and the energy can be delivered to a treatment site through a waveguide, such as a fiber optic waveguide. The incident laser energy can be absorbed within a volume of the target tissue with a tissue penetration depth and pulse direction such that the propagation of the energy from the tissue volume is inhibited and such that the target tissue within the volume reaches the spinodal threshold of decomposition and ejects the volume, for example without substantial damage to tissue adjacent the ejected volume.

Abstract: An apparatus for generating cut surfaces in the cornea of an eye in order to correct ametropia is provided, said apparatus comprising a laser unit, which can focus pulsed laser radiation into the cornea and move it therein in order to generate cut surfaces, and a control unit, which controls the laser unit for generating cut surfaces such that a predetermined lenticle to be removed is separated from the surrounding corneal material in the cornea by at least one cut surface, and that at least two mutually spaced apart cut surfaces are formed as opening cuts, each extending from the lenticle to the anterior corneal surface, the position and shape of the opening cuts being selected such that the opening cuts contribute to the correction of the ametropia of the eye or do not counteract the correction of the ametropia of the eye.

Abstract: Disclosed is an exemplary illumination device for enhancing the brightness of wavelength converting element. The illumination device includes a wavelength converting element operable for receiving light from a light source at a first wavelength range and converting the light to a second wavelength range. The wavelength converting element includes a first face, a second face opposite the first face, and a side edge extending between the first and second faces. A reflective optical element is arranged adjacent the side edge of the wave converting element. The reflective optical element is configured to reflect light in at least the first wavelength range toward the wavelength converting element.

Abstract: Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

Abstract: A quality control accessory (QC accessory) is provided which is adapted for use in linear accelerator quality control or in verification of an arbitrary isocentric radiation treatment plan of a patient or radiation sensitive body. The accessory includes an absorber, a detector and an optional orientation device. The absorber is rotationally symmetric, preferably spherical or hemispherical. The detector is adapted to be fixed in a stationary spatial relationship with respect to the absorber. The optional orientation device is adapted to maintain the two dimensional detector (2d detector) and the absorber in a fixed relative spatial relationship with respect to the beam focus of the linear accelerator, when the gantry is rotated, so that the central axis of the beam is essentially orthogonal to the 2d detector and the phantom axis of symmetry is parallel to or aligned with the central axis of the gantry rotation axis.

Abstract: An eye contact device and assembly for stabilizing a human eye at a selected position in an external coordinate system is disclosed. The device includes an eye-contact member having an inner contact surface for contacting a front surface of an eye, and a vacuum port formed within the eye-contact member by which a negative pressure can be applied between the eye and the contact surface, to stabilize the position of the eye with respect to the device. The device, which is adapted to be biased against the patient's eye, to secure the device to the eye, may be pivotally coupled to a positioning arm, and may carry one or more beam-directing elements by which the position of the device in an external coordinate system can be determined.

Abstract: A system and method for providing treatments of electromagnetic radiation to areas of post-partum abdominal skin. The treatments provide for raising the temperature in a portion of post-partum abdominal skin to a treatment temperature, which is sufficient to reduce the laxity or redundancy of the post-partum skin. In one embodiment the treatment can provide treatment exposures to sub-areas, of an area of post-partum abdominal skin which has been identified for treatment, and bring a temperature of the tissue being treated to at 50° C.

Abstract: An integral laser imaging and coagulation apparatus, and associated systems and methods that allow an ophthalmologist to perform laser retinal surgical procedures with an integral laser imaging and coagulation apparatus disposed at a first (i.e. local) location from a control system disposed at a second (i.e. remote) location, e.g., a physician's office. In some embodiments, communication between the integral laser imaging and coagulation apparatus and control system is achieved via the Internet®.

Abstract: A laser can produce pulses of light energy to eject a volume of the tissue, and the energy can be delivered to a treatment site through a waveguide, such as a fiber optic waveguide. The incident laser energy can be absorbed within a volume of the target tissue with a tissue penetration depth and pulse direction such that the propagation of the energy from the tissue volume is inhibited and such that the target tissue within the volume reaches the spinodal threshold of decomposition and ejects the volume, for example without substantial damage to tissue adjacent the ejected volume.

Abstract: A system and method for using a light source to treat tissue with NIR light. The operation provides for generating higher temperatures in deeper layers of tissue relative to higher layers of tissue. The increased temperature in dermal layers can operate to induce collagen shrinkage, or remodeling. One of the light sources for providing a broad spectrum of NIR light is a filament light. The light from the filament lamp can be selectively filtered, and after filtering this light is applied to the skin, where the selective filtering can enhance the ability to elevate the temperature of deeper layers of tissue, relative to layers of tissue which are closer to the surface of the skin.

Abstract: A method is disclosed for substantially cutting and cauterizing tissue during a surgical procedure. The method involves using a first laser beam to irradiate a first area. The first laser beam is configured in intensity and duration to cut the tissue within the first area, and further causes a temporary increase in an absorptivity of tissue in a second area in proximity to the first area. A second laser beam is used to irradiate the second area while the temporary increase in absorptivity is occurring. The second laser beam has a different intensity than the first laser beam and cauterizes tissue within the second area substantially simultaneously with the cutting of the tissue in the first area.

Abstract: A system includes a laser catheter and a rotating optical member to receive a laser beam along an optical path and rotate to a selected position to redirect the laser beam from the optical path onto one or more selected optical fibers of a laser catheter, wherein a distal end of the laser catheter irradiates an endovascular structure.

Abstract: A gradual ramp-up of output power in a medical laser prevents rapid temperature rise at a fiber tip of a laser handpiece when residual contamination from a prior medical procedure remains on the fiber tip after an extended cooling period. The gradual ramp-up eliminates effects of an acoustic shock wave resulting from the rapid temperature rise to prevent damage to fiber and optical components in the laser device.

Abstract: The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.

Abstract: A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.

Abstract: A laser therapy device includes a solid-state laser configured for a CW operation and including a pump source, and a controller configured to generate at least one first pulse of the laser in a first-pulse operation. The controller is configured to switch on the pump source to a pump power level S1 at least once during the first-pulse operation. A rise time E, after which the pump power level S1 of the pump source is attainable and starting from the time the pump source is switched on, is in a range of 50 ns to 350 ns.

Abstract: A portable, small-footprint laser device contains one or more housings in which a laser energy source and an optical arrangement are disposed. The housing produces a laser beam spot that may be rotated and scanned to apply laser energy to a target area. The laser device receives treatment parameters and uses them to program a treatment regimen in which activation and movement of the housings is automated. The laser device may be used to apply a treatment regimen to a patient's hands or feet that are infected by Onychomycosis. In the treatment regimen, certain wavelengths of laser energy are applied at a predetermined duration. The treatment may be repeated, and a topical anti-fungal medication may be applied to aid in the efficacy of the treatment.

Abstract: Embodiments of an apparatus and method for sealing of tissue during uncontrollable bleeding situations during surgery are described. In one aspect, an apparatus comprises a laser unit and a laser beam delivery unit. The laser unit is configured to emit a laser beam suitable for sealing an opening on a tissue. The laser beam delivery unit is detachably coupled to the laser unit, and is configured to guide and direct the laser beam to seal the opening on the tissue.

Abstract: An apparatus for refractive ophthalmic surgery by laser radiation including a source of radiation which emits a processing beam a beam path for focusing and scanning. The beam path focuses the processing beam into a cornea of an eye and shifts a position of a focus therein. A beam splitting device generates several foci in the cornea and divides the processing beam into a primary beam and at least one secondary beam. The primary and secondary beams have substantially the same cross section as the processing beam which is incident on the beam splitting device and the beam-splitting device introduces a separation between the primary and secondary beams. The primary and secondary beams expand in the beam path. A contact glass induces a pre-defined geometric boundary surface at the cornea.

Abstract: A system is provided for identifying the sufficiency of lesions formed during a tissue ablation procedure. The system captures live and still images from the surgical site and provides composite imaging to the operator. Through the use of the system, the aiming light used to direct ablative energy is captured on the still images and used to indicate locations in a surgical site where energy has been directed. Through the use of processing modules, the system can analyze the lesions and determine the sufficiency thereof.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: A technique for detecting and providing alerts or indications that can be used for controlling or altering the displacement speed of an applicator coupling skin heating energy across a treated skin. A temperature sensor monitors the rate of skin temperature change and provides feedback related to altering the applicator displacement speed according to the rate of skin temperature change. Disclosed is also an applicator for implementing this method.

Abstract: In a method of ablating a tunica of a patient, a laser fiber is inserted into the tunica of the patient. Portions of the tunica are exposed to laser light discharged from the laser fiber. The portions of the tunica that are exposed to the laser light are ablated. In one embodiment, a device is used to control the exposure of the tunica to the laser light. In one embodiment, a penile prosthesis is implanted in the ablated tunica.

Abstract: A therapeutic energy system for performing interstitial laser therapy and brachytherapy includes two categories of components. The first category includes components usable to perform both interstitial laser therapy and brachytherapy. The second category of components includes components usable to perform either interstitial laser therapy or brachytherapy, but not both. The components co-act to apply therapeutic energy to tissue. The components of the first system include components inserted percutaneously into the tissue, such that interstitial laser therapy and brachytherapy can be performed sequentially without removing and re-inserting percutaneous components. Components of the second category include components not requiring additional puncturing of the skin of a patient, such that removing and inserting components of the second category from a patient is done easily and painlessly. An energy probe component does not maintain a cavity around the tumor mass.

Abstract: A light system for medical photodynamic applications comprises an incoherent light source emitting a light with a power and a light guide which has a distal end and an entrance interface. The entrance interface and the light source have a position relative to one another and are able to be positioned relative to one another. The light system further comprises a luminous power meter for measuring a luminous power emitted at the distal end of the light guide, a motorized positioning unit for positioning the entrance interface and the light source relative to one another, and a control unit which controls the positioning unit as a function of the luminous power measured by the luminous power meter.

Abstract: An apparatus and process using a high-power, short-pulsed thulium laser to output infrared laser pulses delivered through an optical fiber, for cutting and ablating biological tissue. In some embodiments, the pulse length is shortened sufficiently to keep inside the stress-confined ablation region of operation. In some embodiments, the pulse is shortened to near the stress-confined ablation region of operation, while being slightly in the thermal-constrained region of operation. In some embodiments, the laser is coupled to a small low-OH optical fiber (˜100 ?m diameter). In some embodiments, the device has a pulse duration of about 100 ns for efficient ablation; however in some embodiments, this parameter is adjustable.

Abstract: The present invention relates to an apparatus for optical surgery and to the method for controlling same, and provides the apparatus for optical surgery and a method for controlling same, comprising: a cutting open-energy source for generating the cutting open-energy for cutting open a surgery area; a hemostasis energy source for generating energy for hemostasis, which is formed separately from the cutting open-energy source, for stopping bleeding at the cut open surgery area; a hand piece, which is connected to the cutting open-energy source and the hemostasis energy source, for providing the cutting open-energy and the hemostasis energy to the surgery area; and a control part for controlling the cutting open-energy and the hemostasis energy, which are provided through the hand piece.

Abstract: A system may include a laser configured to output laser light with a wavelength between 600-780 nm, and a radiation delivery device. The radiation delivery device may be configured to output the laser light to a mesh or suture implant so that the mesh or suture implant is exposed to the laser light. The mesh or suture implant is attached to a patient and surrounded at least partially by tissue of the patient. The mesh or suture implant is vaporized by exposure to the laser light while tissue exposed to the laser light is not damaged by the laser light.

Abstract: A tissue ablation device employs one or more energy emitters (21) and one or more photoacoustic sensors (22) in a cooperative arrangement for applying a tissue ablation therapy to a tissue (60). In operation, the energy emitters (21) emit a tissue ablation beam (TA) into a target portion of the tissue (60) to form a lesion (61) therein, and alternatively or concurrently emit a photoexcitation beam (PE) into the target portion of the tissue (60) to excite a photoacoustic response from the tissue (60). The photoacoustic sensor(s) (22) sense the photoacoustic response of the tissue (60).

Abstract: The present invention relates to a system for treatment of skin wounds, comprising an energy source for activation of a biochemical healing effect, and at least one dressing intended to be placed on the wound before the step of activation by said energy source, characterized in that said dressing comprises an identification means interacting in a contactless manner with a sensor that triggers the function of the energy source only when the distance between the sensor and said identification means is below a threshold value.

Abstract: The use of multiple pulses having controllable temporal relationships can produce higher optical ablative pulse peak power using split by color pulses. Split pulses can be controllably delayed to increase pulse peak power, average power and/or repetition rate in single-amplifier or multi-amplifier systems.

Abstract: An imaging and diagnostic system and method to differentiate between malignant and non-malignant tissue of a prostate and surrounding region. The system acquires imaging data from the prostate and surrounding proximal region, and processes the data to differentiate areas of tissue malignancy from non-malignant tissue. A sectioning device or ablative device is provided. The ablative device is operable by automation for receiving the imaging output coordinates and defining the trajectory and quantity of energy or power to be delivered into the malignant tissue. A control system determines calculated energy or power to be deposited into the malignant tissue during ablation, to minimize destruction of the non-malignant tissue within the prostate and surrounding tissue. The system operates on generated ablative device output data.

Abstract: A device and a method for treating Vulnerable Plaque by pulsed focused energy is described. The present invention describe a device and a method for a) breaking through plaque blocking arteries (totally occluded arteries) so that wires and stents can introduced to open the blocked or totally occluded arteries, and b) applying a controlled amount of energy to VP (possibly with cooling or energy removal applied to the surface layers) so that at least some of the constituents of the VP are stabilized or denatured so they can no longer cause blood clotting or are stabilized to prevent emergence into the blood stream and thus prevent clotting. Additionally an imaging method (for example, OCT, side looking OCT, IVUS, Ultrasound, OCT, thermography, IR imaging, Florence imaging, luminescent imaging, MRI, Videography, or other imaging technologies, allow viewing of the progress of the damage caused to the VP blood clot—causing components or the progress in the stabilization of the VP.

Abstract: Devices, systems, and methods control pulse energies of excimer and other lasers, particularly for refractive correction in which a pulse rate, pulse energy, or other parameters of a pulsed laser is varied during use. A calibration laser mode may be used to fire a series of laser pulses to characterize a correlation between laser energy and a laser operation parameter (typically discharge high voltage) throughout a range. During an operation mode, subsequent voltages may be set based on energies of prior pulses while accounting for a curve or change in rate of the correlation.

Abstract: Systems and techniques for providing variable scanning control in delivering a laser beam of laser pulses to a surgical target are provided. The described systems and techniques can be used for laser surgery within the anterior segment of the eye and the crystalline lens via photodisruption caused by laser pulses from a femtosecond laser.

Abstract: A laser system for the irradiation of an eye includes a laser configured to emit a laser beam; a focusing device configured to focus the laser beam; and a beam-shaping device configured to generate a predetermined intensity distribution in a cross section of the laser beam such that an intensity minimum of the laser beam is disposed in region of a center of the cross section of the laser beam.

Abstract: Skin disorders such as, for example, atopic dermatitis, dyshidrosis, eczema, lichen planus, psoriasis, and vitiligo, are treated by applying high doses of ultraviolet light to diseased regions of a patients skin. The dosage employed exceeds 1 MED, an MED being determined for the particular patient being treated, and may range from about 1 MED to about 20 MED or higher. The ultraviolet light has a wavelength within the range of between about 295 nanometers to about 320 nanometers and preferably is between about 300 nanometers and about 310 nanometers. High doses of ultraviolet light are restricted to diseased tissue areas so as to avoid risk of detrimental side affects in healthy skin, which is more susceptible to damage from UV light. Cooling the skin prior to and/or while exposing the skin to the UV light can be used to minimize tissue damage resulting from exposure to the UV light. Higher doses of UV light can therefore be employed without injurious affects.

Abstract: The invention related to a method and a system for non- or minimally disruptive photomanipulation of the lens and/or its constituents collectively or selectively of an animal or human eye, comprising focusing a treatment laser beam into a selected part of the lens and/or its constituents collectively or selectively where treatment is intended to occur, pulsing of said treatment laser beam, scanning the beam over at least a part of the lens, measuring one or more types of radiation from the said selected part and utilizing this measurement to decide to stop the said treatment laser beam or to adjust at least one of the parameters: focus, intensity, wavelength, pulse length, repetition frequency, pulse train length, scan velocity, size of scanned volume, scan repetitions, and scan pattern of said treatment laser beam.

Abstract: An integral laser imaging and coagulation apparatus, and associated systems and methods that allow an ophthalmologist to perform laser retinal surgical procedures with an integral laser imaging and coagulation apparatus disposed at a first (i.e. local) location from a control system disposed at a second (i.e. remote) location, e.g., a physician's office. In some embodiments, communication between the integral laser imaging and coagulation apparatus and control system is achieved via the Internet®.

Abstract: A dermatological treatment device is disclosed for generating a matrix of two dimensional treatment spots on the tissue. A handpiece carries a laser which generates a beam of laser pulses. The pulses are focused onto the tissue with a lens system. A diffractive element is positioned between the laser and the lens system for splitting the laser beam into a plurality of sub-beams. A scanner translates the beam over the diffractive element to generate the two dimensional spot pattern. The laser has a semi-monolithic resonator design with one integral end minor defining the output coupler and a second, independent mirror for adjustment.

Abstract: A method for ablating a presbyopic lens for restoring accommodation in human eye and a system thereof wherein a laser beam is directed obliquely to carry out multiple photoablations in circular way within the lens behind the iris and preferably near the edge or equator of the lens and/or in the vicinity of zonules to re-establish accommodation of the lens lost due to presbyopia.

Abstract: A blood test device using a laser as a puncture member. More specifically, in a blood test device using a laser as a puncture member, the skin can be fixed at a definite position by raising the punctured skin under negative pressure, and thus the skin is brought into close contact with a blood sensor and the laser is focused on the vicinity of the blood sensor face. Thus, it is possible to provide a blood test device of the laser puncture type in which the skin can be surely punctured while giving little pain to a patient.

Abstract: An apparatus for material processing by laser radiation, including a laser source which emits a processing beam, and a beam path for focusing and scanning, the beam path focusing the processing beam into a processing volume and shifting the position of the focus therein. A beam splitting device generates several foci in the processing volume and the beam splitting device splits the processing beam up into a primary beam and at least one secondary beam and leaves the cross section of the beam in a pupil plane of the beam path unchanged during said division and introduces an angle of separation between the primary and secondary beams, so that these beams expand in the beam path in directions which differ by the angle of separation.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.