Abstract: A bariatric device and method of causing at least partial satiety in a recipient includes positioning a body in a recipient, the body having a wall defining a lumen, the wall configured to generally conform to the shape and size of the proximal cardiac portion of the stomach. Force is exerted with the wall on the proximal cardiac portion of the stomach in the absence of food thereby activating receptors located in the proximal cardiac portion of the stomach, thereby influencing a neurohormonal feedback mechanism of the recipient to cause at least partial satiety by augmenting fullness caused by food and simulating fullness in the absence of food.

Abstract: Apparatuses for manipulating a collapsible medical device include a sheath, a first shaft including a first grasping member and a second grasping member. The second grasping member is separated from the first grasping member by a distance. The collapsible medical device may be manipulated by actuating the first grasping member and the second grasping member and by increasing the distance between the first grasping member and the second grasping member. Methods of using the apparatuses are provided.

Abstract: A stent delivery system for delivering a stent, the stent delivery system having a push catheter, a guide member, and an elongated stent securing material having a first portion arranged to a push catheter outer surface, a second portion, a third portion, and a fourth portion arranged to the push catheter outer surface, in that order. The first portion and the fourth portion are arranged to the push catheter outer surface such that only one of the first portion and the fourth portion is present on a cross-section plane orthogonal to the longitudinal axis. The stent delivery system is configured to have a secured configuration in which the guide member is arranged within a push catheter lumen and a stent lumen and through a loop formed by a section between the second portion and the third portion to secure the stent.

Abstract: A device and method for treating bone fractures/lesions using an inflatable body is provided. The inflatable body includes a balloon having a substantially flat horizontal surface for quick easy insertion into bone beneath the fracture so as to align misaligned fragments of the fracture and/or to collapsed bone. The body has a shape and size to compress at least a portion of the cancellous bone to form a cavity in the cancellous bone and/or to restore the original position of the outer cortical bone, if fractured or collapsed. The inflatable body has a stylet attached to its distal end so that once the inflatable body is deflated it can be twisted about the stylet to have a smaller profile so as to be easily withdrawn from the bone.

Abstract: The invention relates to an implantable radiopaque stent adapted to be disposed in a body lumen. In one aspect of the invention, a plurality of elongate filaments including one or more radiopaque filaments are arranged to form a hollow tubular structure having a tubular wall that defines an inner surface and an outer surface and opposing first open end and second open end. One of the open ends of the stent is formed by an intersection of adjacent filament ends. A radiopaque compound is applied to the intersection, the radiopaque compound comprising radiopaque material and polymeric material. The radiopaque compound and radiopaque filament provide improved external imaging of the tubular structure on imaging equipment.

Abstract: A coupling device, set to be linked to an interventional delivery system, for coupling and releasing a medical implant. The coupling device comprises a generally tubular channel sized and shaped to be conducted in an intravascular catheter and a pivot extended in and along the generally tubular channel having a distal end comprising a lower surface for applying pushing force a medical implant and an upper surface, mounted above the lower generally tubular surface and having at least one niche for receiving at least one anchoring element of the medical element so that a tip of each the anchoring element is placed between the lower and upper surfaces.

Abstract: A liner support frame is configured to be positioned in a gastrointestinal tract of a human and to support a liner which inhibits nutrient absorption and anchor the liner in place in the gastrointestinal tract, the liner support frame includes a plurality of frame members connected to one another so that the liner support frame possesses a plurality of openings. The liner support frame includes a plurality of frame portions arranged axially and possessing different tapers.

Abstract: Systems, methods, and kits for performing endoscopic fusion with neuromonitoring. The endoscopic fusion may be performed, for example, through a cannula providing a portal to the disc space. Throughout various steps in the procedure, neuromonitoring may occur to minimize the possibility of injuring or contacting a nerve.

Abstract: A seal anchor member defines a housing defining a longitudinal axis, the housing having leading and trailing ends, and including a plurality of lumens extending between the leading and trailing ends, each lumen being adapted for substantially sealed reception of an object therein and defining a longitudinal axis, wherein at least two of the lumens define longitudinal axes that are non-parallel to facilitate angled, at-rest placement of multiple instruments within the seal anchor member.

Abstract: A method of forming an access opening through a psoas muscle to a patient's spine includes laterally inserting a stimulating dilator into the psoas muscle. The stimulating dilator has a stimulation channel formed in an outer surface thereof. An electrical pulse is transmitted via an EMG into the stimulating dilator to locate a position of a nerve in the patient's psoas muscle. The stimulating dilator is laterally inserted through the psoas muscle and toward the patient's spine in a way that avoids the nerve. A stimulating probe is inserted into the stimulation channel along the outer surface of the stimulating dilator while transmitting an electrical pulse via the EMG into the stimulating probe to verify the position of the nerve.

Abstract: The present invention provides for compositions and constructs for craniofacial reconstruction implants, and methods for making and using same. Specific embodiments provide for a biocompatible scaffold having an auricular shape and a permanent bendable framework within the scaffold, wherein the permanent bendable framework allows deformation and return to pre-deformation shape, and thus maintains the auricular shape of the scaffold.

Abstract: A stent delivery system can include a core member, first and second restraints, and a stent engagement component. The core member can have a distal segment. The first and second restraints can be coupled to the core member distal segment and axially spaced apart from each other to provide an axial gap. The first and second restraints can each have an outer profile that tapers radially inwardly in directions away from the gap. The stent engagement component can be at least partially disposed in the axial gap between the first and second restraints such that the component is slidably and rotatably coupled to the core member distal segment.

Abstract: A scaffold is mounted on a balloon of a balloon catheter. The scaffold has closed cells which deform upon balloon expansion and generate forces that cause struts or other components of the scaffold to deflect outwardly to a diameter that is greater than the inflated diameter balloon. The deflected struts apply forces to fracture plaque of other hardened lesions and also form an annular gap surrounding the balloon to provide for bypass flow of blood or other body fluids. A sheath may be located over the deflected struts to protect adjacent tissue structures from the deflected struts and/or to further define the gap.

Abstract: Detachment of an implant from a delivery assembly can be electrolytic. A distal end of a core member and a proximal end of an implant can be joined together by one or more weld joints disposed axially between the distal end and the proximal end, the one or more weld joints being further disposed at a radially outermost periphery of the distal end and a radially outermost periphery of the proximal end. Delivery of a detachable implant as described herein can include advancing, to a target location within a patient, an implant having a proximal end and being connected to a distal end of a core member by one or more weld joints, as described above, and separating the implant from the core member by corroding the one or more weld joints.

Abstract: An apparatus for releasably engaging an implantable medical device during delivery includes an elongate, tubular body having an open distal end a plurality of deflectable jaw members extending distally from the distal end of the body and terminating in distal tip portions, and an actuating member slidably disposed within the body and including a distal end portion operable to prevent inward deflection of the jaw members when positioned proximate the distal tip portions. The jaw members are adapted to releasably engage an engagement feature of the implantable medical device.

Abstract: The present disclosure provides an inflatable weight control device that is implanted long-term with an endoscope in obese and bariatric human patients to promote early and prolonged satiety. The device includes a flexible member coupled to a valve body assembly and an elongated durable module residing within the flexible member. The flexible member is selectively inflated to form two bulbs with a central passageway extending through the bulbs and the valve body assembly. Once the bulbs are inflated, the device is retained within the patient's pyloric valve to form a gastric outlet obstruction wherein chyme accumulates and then is directed through the central passageway to reach the patient's duodenum. Due to its unique configuration, the implanted device reduces gastric outflow which results in early and prolonged satiety when the patient consumes normal-sized meals or food portions, thereby reducing food consumption and increasing the patient's weight loss.

Abstract: Disclosed herein are embodiments of a prosthesis and delivery device, as well as methods of use. The delivery device can be composed of an inner retention assembly configured to carry an expandable prosthesis to an in situ target location. The inner retention assembly can slide within an outer elongate hollow member which can cover the expandable prosthesis. The outer elongate hollow member can further be longitudinally collapsed into a receiving member located at the distal end of the outer elongate hollow member.

Abstract: An intestinal implant includes a proximal anchor self-expandable from a radially compressed position to a radially expandable position for engagement with a wall of the intestinal lumen and a flexible sleeve coupled to the anchor. The sleeve is implanted with the anchor downstream from the pylorus and the sleeve extending further downstream through the intestinal lumen.

Abstract: An volume filling device for treatment of obesity is placed outside the stomach wall of the patient to reduce the inner volume of the stomach, thereby affecting the patient's appetite. By providing the volume filling device outside the stomach wall, contact with stomach acids is avoided, thereby increasing the life of the device. Furthermore including a stretching device to stretch a portion of the stomach wall to further affecting the patient's appetite.

Abstract: One preferred embodiment includes a stent delivery system including a retractable sheath and an outer stability sheath. The stability sheath freely rotates relative to the retractable sheath, relieving compression forces caused by twisting of stability sheath in when in a tortuous conformation.

Abstract: Disclosed herein are vaso-occlusive devices for forming occluding the vasculature of a patient. More particularly, disclosed herein are vaso-occlusive devices having a textured outer surface for promoting tissue in-growth.

Abstract: A method for producing an in-vivo indwelling member includes a step of winding a metal wire (1) to form a primary coil (2-4), a step of giving the primary coil (2-4) a shape to form a secondary coil (10-19), and a step of inserting the secondary coil (10-19) into an inner hollow section (43) of a shaping mold (40). The secondary coil (10-19) includes different patterns such as a helical shape (20, 22-25, 29, 61, 63-65), a linear shape (21, 26, 28), and a circular arc shape (27, 50-53, 60, 62). When the secondary coil (10-19) is pushed into the inner hollow section (43), the secondary coil (10-19) makes contact with the inner wall surface of the inner hollow section (43), and a portion between different patterns is randomly curved. Accordingly, the in-vivo indwelling member has a three-dimensional structure that corresponds to the shape of the inner hollow section (43). The in-vivo indwelling member is less likely to deviate from the inside of an aneurysm when released into the aneurysm.

Abstract: A deployment device having a carrier tube, for bringing a sealing plug into position within a puncture tract or incision and deploying the sealing plug within the incision or puncture tract, towards the outer surface of a tissue puncture, is provided. The carrier tube is designed to facilitate easier deployment and improved compaction of the sealing plug, the sealing plug often made of collagen. The carrier tube is adapted to prevent the premature hydration of the sealing plug, where premature hydration of the sealing plug may result in difficulty in deploying the sealing plug. The carrier tube is designed to facilitate easier loading of puncture tract closing elements into the distal end of the carrier tube.

Abstract: An endoluminal prosthesis for placing in a body passage of a patient, includes a ureteral stent, the ureteral stent having a generally tubular housing having a proximal end and a distal end and a lumen longitudinally disposed therethrough, with cation-exchange resin beads disposed within the tubular housing, and at least one anchoring mechanism disposed on a distal end of the tubular housing, where at least one retention screen is disposed within the lumen of the ureteral stent configured to retain the plurality of beads.

Abstract: Systems, apparatuses, and methods for treating native heart valves are disclosed herein. A system for delivering a prosthetic device into a heart of a patient includes an elongated catheter body and a delivery capsule. The delivery capsule can be hydraulically driven to deploy at least a portion of a prosthetic heart valve device. The delivery capsule can release the prosthetic heart valve device at a desired treatment site in a patient.

Abstract: An inter-ureter signaling device intended to provide a surgeon with a signal to identify when a ureter is grasped by a surgical clamping device, such as a pair of forceps, the device being comprised of a catheter, a signal generator, and wiring, such that when the catheter component of the device, having been inserted into a ureter, is compressed by the surgical clamping device an electrical circuit is closed and the signal generator generates a human perceptible signal, indicating that the clamp has been placed on the ureter.

Abstract: A prosthesis (14) that is useful as an anti-reflux device or an anti-obesity device within a gastro-intestinal tract of a living organism, such as a human, comprises an elastic portion including a helical elastic spring (15) embedded in a biocompatible material.

Abstract: Space-occupying devices for treating voids within the body are disclosed. The devices can have multiple elements connected to a flexible leader. The devices can be coated by a binding agent. The devices can also be fillable. Methods of making and using the devices are also disclosed.

Abstract: A cardiac ablation device, including a steerable catheter (10) and an expandable ablation element (18) incorporating one or more balloons (20,22) at the distal end of the catheter, has a continuous passageway (28, 30) extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. A probe (72) carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop (82) which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the sensor probe.

Abstract: A dilation introducer for orthopedic surgery is provided for minimally invasive access for insertion of an intervertebral implant. The dilation introducer may be used to provide an access position through Kambin's triangle from a posterolateral approach. A first dilator tube with a first longitudinal axis is provided. A second dilator tube may be introduced over the first, advanced along a second longitudinal axis parallel to but offset from the first. A third dilator tube may be introduced over the second, advanced along a third longitudinal axis parallel to but offset from both the first and the second. An access cannula may be introduced over the third dilator tube. With the first, second, and third dilator tubes removed, surgical instruments may pass through the access cannula to operate on an intervertebral disc and/or insert an intervertebral implant.

Abstract: A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releaseably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion.

Abstract: An energy treatment device includes a probe in which a suction path is defined inside along a longitudinal axis to a distal surface portion. The probe includes a first protrusion protruding an outer peripheral distal end of an outer peripheral portion toward a first perpendicular direction perpendicular to the longitudinal axis and perpendicular to open/close directions of the jaw. The distal surface portion includes an inclined plane in which it goes toward a distal direction side as it goes from the first perpendicular direction toward a second perpendicular direction that is opposite to the first perpendicular direction, the inclined plane extending from a first end position, located to the first perpendicular direction side of a first root position of a first protrusion, to a second end position, located to the second perpendicular direction side of the suction path.

Abstract: A directional sequential dilation system includes a dilation tube assembly having a plurality of cylindrical, nesting directional dilation tubes including an initial cylindrical dilation tube that provides a passage for neuro-monitoring. Subsequent cylindrical directional dilation tubes sequentially increase in size including the increase in diameter. Each tube is configured to nest onto a previous cylindrical directional dilation tube via an off-centered structure formed in each of the subsequent cylindrical directional dilation tubes. The off-centered cutouts allow the subsequent cylindrical dilation tubes to dilate the soft tissue while at the same time sequentially migrate the incision dilation in a particular direction and distance from the initial cylindrical dilation tube insertion point (i.e. the initial neuro-monitoring insertion point). The directional sequential dilation system is particularly useful in spinal surgery.

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

Abstract: In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.

Abstract: An apparatus for elevating tissue within a body, including a tubular member having a proximal end and a distal end and a central axis defined therethrough, in which the tubular member comprises a first lumen and a second lumen, separately formed therein, a balloon secured to a region of the tubular member, in which a region of the tubular member is engagable with an injection mechanism, in which the engaged injection mechanism is engagable to be in communication with the first lumen of the tubular member, and in which the first lumen of the tubular member provides a path to an interior of the balloon.

Abstract: A surgical balloon composed of an aseptically recovered umbilical cord vessel is provided. Methods of preparing a balloon and methods of using the same are also provided.

Abstract: A delivery device for an annular implant is provided, comprising an annular implant having an adjustable dimension; a plurality of movable elongated deployment members, each having a proximal end and a distal end and an annular implant deployment region therebetween; and a distal joining member for joining the distal ends of the deployment members, wherein the deployment members are expandable by an expansion means to a deployment configuration, and the implant deployment regions of the deployment members are substantially parallel in an expanded configuration. The annular implant can comprise an adjustment mechanism in communication with a releasably attached elongated adjustment tool, whereby the size or shape of the annular implant can be incrementally adjusted.

Abstract: A bariatric device and method of causing at least partial satiety in a recipient includes positioning a body in a recipient, the body having a wall defining a lumen, the wall configured to generally conform to the shape and size of the proximal cardiac portion of the stomach. Force is exerted with the wall on the proximal cardiac portion of the stomach in the absence of food thereby activating receptors located in the proximal cardiac portion of the stomach, thereby influencing a neurohormonal feedback mechanism of the recipient to cause at least partial satiety by augmenting fullness caused by food and simulating fullness in the absence of food.

Abstract: A device for recovering one or more blastocysts from the uterus of a human includes an outer guide member for insertion into a cervical canal of the human. The outer guide member includes a distal portion with an activatable seal for isolating the uterus from the external environment and defines a lumen having a longitudinal axis. The device also includes an inner catheter located within the lumen and slidable along the longitudinal axis of the lumen relative to the outer guide member. The inner catheter has a distal tip positionable distally of the seal to extend into the uterus and includes a fluid delivery lumen terminating at a distal fluid delivery port for delivering fluid into the uterus. The device defines a distal suction port for aspirating fluid and entrained blastocysts from the uterus. The distal fluid delivery port and the distal suction port are arranged such that, in use, fluid delivered from the distal fluid delivery port travels through the distal suction port to the uterus.

Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.

Abstract: A reconfigurable delivery system is disclosed having a multi-lumen delivery catheter configuration that permits the delivery and staged release of a self-expanding main vessel stent-graft and a delivery sheath configuration that permits the introduction of various medical devices for the delivery and implantation of various branch vessel stent-grafts that are to be mated with the main vessel stent-graft. A method is disclosed wherein the delivery system is first used in the multi-lumen delivery catheter configuration to deliver and release a main vessel stent-graft that is configured for placement in the abdominal aorta for treatment of short-neck infrarenal, juxtarenal, and/or suprarenal aneurysms and then used in the delivery sheath configuration to facilitate the delivery of branch vessel stent-grafts that are configured to extend from the main vessel stent-graft into a respective renal artery.

Abstract: A surgical apparatus includes a seal anchor member including a compressible material. The seal anchor member may be adapted to transition between a first condition for insertion of at least a portion of the seal anchor member within a tissue tract and a second condition to facilitate a securing of the seal anchor member within a tissue tract and in substantial sealed relation with tissue surfaces defining a tissue tract. The seal anchor member may define at least one port extending between the proximal and distal ends, the at least one port being adapted for the reception of an object whereby compressible material defining the at least one port is adapted to deform to establish a substantial scaled relation with the object. The seal anchor member may include indicia that indicates to a user a location at which the member may be cut to reduce the size of the member.

Abstract: A medical device package includes an elongate tubular holder having a first and a second detachable tip, and a medical device positioned within a cavity and contained within the holder via the first and second detachable tips. The medical device has a self-shaping bias and is loaded in opposition to the bias via contact with an inner surface of the holder defining the cavity. The first and second detachable tips may include snap-off tips, such that upon detachment the cavity is opened for removing the medical device. Related methodology is disclosed.

Abstract: An infusion catheter includes an elongate catheter body having a longitudinally extending fluid supply passage, and a plurality of stellate side ports for infusing a treatment fluid from the fluid supply passage into a body lumen of a passage. Each of the stellate side ports is defined by sets of at least three convergent leaves having an attached basal edge, a terminal tip, and first and second free edges extending between the attached basal edge and the terminal tip. Making an infusion catheter includes forming a plurality of stellate side ports in fluid communication with a fluid supply passage of an elongate catheter body, each of the stellate side ports being defined by a set of at least three convergent leaves, and setting an infusion length of the infusion catheter during the forming step via spacing the stellate side ports between proximal and distal ends of the elongate catheter body.

Abstract: The present embodiments provide apparatus and methods suitable for coupling a graft member to tissue, closing a bodily opening, and the like. In one embodiment, a tacking device comprises a wire having first and second ends, and further having delivery and deployed states. In the contracted state, the wire comprises an elongated configuration that is substantially parallel to a central longitudinal axis. In the expanded state, the wire comprises a head region and a body region, the head region comprising at least one full turn having a first diameter, and the body region comprising at least two full turns having a second diameter, wherein the first diameter is greater than the second diameter. One or more of the tacking devices may be delivered using a laparoscopic, endoscopic or percutaneous approach.

Abstract: A stent removal device for removing or repositioning a stent from within a lumen is provided. The stent typically comprises at least one element arranged circumferentially about the stent. The stent removal device includes a tube positioned within the lumen proximate to the stent, wherein the tube is capable of receiving at least a portion of the stent. The stent removal device also includes a pusher positioned within the tube capable of engaging the stent and/or the element. The stent removal device further includes a hook positioned within the tube and including a hook member capable of engaging the element such that force applied to the hook causes the stent to purse string.

Abstract: A surgical instrument for use with a surgical portal apparatus includes an elongate shaft having proximal and distal ends and defining a longitudinal axis and a dilating member disposed at the distal end of the elongate shaft. The dilating member has a first longitudinal arc segment and a second longitudinal arc segment in diametrical opposed relation to the first longitudinal arc segment. The first and second longitudinal arc segments define respective first and second radii of curvature transverse to the longitudinal axis. The first and second radii of curvature decrease from proximal to distal to define a generally tapered configuration of the dilating member. The first radius of curvature is greater than the second radius of curvature at predefined longitudinal positions of the dilating member such that the first longitudinal arc segment extends distally beyond the second longitudinal segment to define a penetrating tip.

Abstract: An occluding device for occluding fluid flow through a lumen of a body vessel. The device comprises a coil and fibers attached to the coil. The coil has about 5 to 60 grams of initial tension to facilitate the coil to fold when deployed. The fibers extend from the coil at a length.

Abstract: A surgical access device includes a proximal housing having proximal and distal end portions, the distal end portion of the housing being configured and adapted to engage a proximal portion of a flexible wound retractor. The proximal housing can be provided with a plenum chamber being defined therein, the plenum chamber being in fluid communication with at least one nozzle. The nozzle is preferably configured to direct pressurized fluid in an axial direction from the plenum chamber into a central bore of the surgical access device to provide a constant gaseous seal around a surgical instrument inserted therethrough, while inhibiting a loss of pressurized fluid from the body cavity therethrough. The plenum chamber can be adapted and configured to receive pressurized fluid and conduct the pressurized fluid to the at least one nozzle.