Absorbable In Body Patents (Class 606/230)
  • Publication number: 20080195147
    Abstract: Barbed surgical sutures comprised of surface eroding materials are provided having increased degradation rates due to the formation of barbs and an increase in the surface area of the suture.
    Type: Application
    Filed: February 9, 2007
    Publication date: August 14, 2008
    Applicant: TYCO HEALTHCARE GROUP LP
    Inventor: Joshua Stopek
  • Publication number: 20080161831
    Abstract: A buttress for use with circular surgical staplers that does not require adhesive to securely fasten the buttress to the stapler. Following cutting and stapling by the circular stapler, the buttress has an adaptive opening through its central region with a diameter smaller than the outer diameter of the stapler anvil. Because of relief features built into the buttress, the stapler anvil may be pulled through the buttress material without causing permanent alteration to the buttress. These relief features may be provided regardless of whether the buttress is made of inelastic or elastic materials. The buttress is generally circular in shape with an outer diameter sized to coincide with the outer diameter of the stapler body staple compression surface and the outer diameter of the anvil compression surface of a circular stapler with which it is used. Prior to surgical use, the buttress is attached to the stapler with disruptable portions extending from outer perimetal areas of the buttress.
    Type: Application
    Filed: January 16, 2008
    Publication date: July 3, 2008
    Inventors: Ann M. Bauman, Stuart E. Broyles, Jerald M. Crawley, John R. Daugherty, Norman Pih
  • Publication number: 20080161851
    Abstract: The invention concerns absorbable, thermally steam-treated, surgical suture based on polyglycolic acid and/or lactide copolymer comprising rapid degradation and rapid decrease in knot-pull breaking strength under in vivo conditions and an initial knot-pull breaking strength which is high for the rapid degradation.
    Type: Application
    Filed: February 3, 2006
    Publication date: July 3, 2008
    Inventors: Erich Odermatt, Jurgen Egloff, Rainer Bargon, Erhard Muller
  • Publication number: 20080161850
    Abstract: A first extruded member in joined to a molded member to form an integrated component. In one exemplary form, a surgical anchor is overmolded onto the end of an extruded suture to form a suture/anchor system.
    Type: Application
    Filed: December 28, 2006
    Publication date: July 3, 2008
    Inventors: William Bruce Weisenburgh, Michael S. Cropper, Robert P. Gill, David T. Martin, Christopher J. Hess, James W. Voegele
  • Patent number: 7378144
    Abstract: A device is formed by the process into a bone screw or fastener, wherein the head has a degree of polymer alignment and strength, and wherein the shank has a higher degree of polymer alignment and strength. In practice of the present invention, the polymer slug is pressed into the die cavity by the actuation of ram press, causing the slug to conform to the die cavity. Through this process, the polymer molecular orientation is aligned to different degrees, in different zones of the device.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: May 27, 2008
    Assignee: Kensey Nash Corporation
    Inventors: Joseph DeMeo, Patrick E. Hearn, Robert L. McDade
  • Publication number: 20080119893
    Abstract: The present invention provides a biocompatible suture material made from denatured human serum albumin. The suture material can be constructed by molding and denaturing a liquid human serum albumin, or by precision cutting a denatured albumin lamina into thin, threadlike ribbons. The denatured albumin material is strong, flexible, absorbable and biocompatible based on both in vitro and in vivo testing.
    Type: Application
    Filed: October 10, 2007
    Publication date: May 22, 2008
    Inventor: Yasmin Wadia
  • Publication number: 20080109036
    Abstract: Barbed surgical sutures and a method of forming a barbed surgical suture from a degradable material are provided having degradation rates tailored to provide the suture with a desired mass loss profile.
    Type: Application
    Filed: November 2, 2006
    Publication date: May 8, 2008
    Applicant: TYCO HEALTHCARE GROUP LP
    Inventors: Joshua Stopek, Matthew D. Cohen
  • Publication number: 20080103525
    Abstract: Silk/absorbable polyester hybrid medical devices for tissue repair and regeneration are formed of degummed, naturally produced, multifilament silk yarn in combination with at least one absorbable polyester in the form of a surface coating, with or without an antimicrobial agent, for producing value-added braided silk sutures and multifilament yarn, as well as silk/absorbable polyester fiber composites, for producing tailored hybrid sutures, meshes, and scaffolds for tissue regeneration.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 1, 2008
    Inventor: Shalaby W. Shalaby
  • Patent number: 7357810
    Abstract: A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: April 15, 2008
    Assignee: Ethicon, Inc.
    Inventors: Ilya Koyfman, Terry E. Lawler, Robert C. Di Luccio, Dennis D. Jamiolkowski
  • Patent number: 7329271
    Abstract: A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 12, 2008
    Assignee: Ethicon, Inc.
    Inventors: Ilya Koyfman, Terry E. Lawler, Robert C. Di Luccio, Dennis D. Jamiolkowski
  • Patent number: 7321008
    Abstract: Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with diketene acetals, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: January 22, 2008
    Assignee: United States Surgical Corporation
    Inventors: Steven L. Bennett, Kevin Connolly, Elliott Gruskin, Ying Jiang
  • Patent number: 7192437
    Abstract: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ?-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Surgical sutures made of mono- or multifilament yams of the present copolymers will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: March 20, 2007
    Assignee: Poly Med Inc
    Inventor: Shalaby W. Shalaby
  • Patent number: 7148315
    Abstract: Monomer addition methodology is provided to adjust monomer addition rates to a polymerization reactor. Advantages of the invention include control of bioabsorbable copolymer structure, improvement of monomer conversion, control of reaction temperature, and reduced reaction time. The overall result is an improved process and enhanced product performance. The technology is particularly useful in the copolymerization of monomers with different reactivity ratios, such as glycolide/lactide copolymers and glycolide/caprolactone copolymers. Monomer reactivity ratios and reaction kinetics are utilized to adjust monomer addition rates.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: December 12, 2006
    Assignee: Ethicon, Inc.
    Inventors: Modesto Erneta, Terry E. Lawler
  • Patent number: 7144412
    Abstract: A method of wound closure comprising providing a gold suture and closing the laceration with the gold suture. The laceration is closed by: inserting the suture into the dermis and through the subcutaneous fat layer on one side of the laceration; inserting the suture at the base of the laceration; inserting the suture through the subcutaneous fat layer and into the dermis on the other side of the laceration to form a loop under the skin; repeating the steps in another insertion 3 to 5 mm from the loop in a continuous or interrupted manner to close the laceration; and tightening the suture line by applying tension to the loops to bring one side of the laceration into contact with the other side of the laceration.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: December 5, 2006
    Assignee: Wolf Medical Enterprises, Inc.
    Inventors: Bradley R. Wolf, Igor A. Bogin, Ruben A. Bogin
  • Patent number: 7141302
    Abstract: A suture material for surgery comprises one or more filaments and is formed with a coating, which is characterized in that the coating at least partly comprises a bioresorbable polymer, which is essentially formed from a random terpolymer with a completely amorphous structure.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: November 28, 2006
    Assignee: Deutsche Institute fur Textil-und Faserforschung Stuttgart Stiftung . . .
    Inventors: Erhard Mueller, Heinrich Planck, Sven Oberhoffner
  • Patent number: 7129319
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: October 31, 2006
    Assignee: Poly Med Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 7070858
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: July 4, 2006
    Assignee: Poly Med Inc
    Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
  • Patent number: 7070610
    Abstract: The present invention relates to a monofilament suture prepared by co-extruding polymers having different Young's moduli and to a process for preparing the same. The suture is prepared in such a form that a polymer having a high Young's modulus surrounds a polymer having a low Young's modulus. The monofilament suture prepared by the present invention has excellent knot security, flexibility and/or knot strength.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: July 4, 2006
    Assignee: Samyang Corporation
    Inventors: Jung-nam Im, Jang-il Seo, Chong-taek Hong, Hye-sung Yoon, Chaul-min Pai
  • Patent number: 7048753
    Abstract: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ?-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Disclosed are coated surgical constructs including sutures made of multifilament yarns of the present copolymers and coated with nitrogenous copolyesters which will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: May 23, 2006
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 7029490
    Abstract: A high strength abrasion resistant surgical suture material with improved tie down characteristics is color coded for visualization and identification purposes. The suture features a multifilament cover formed of strands of ultra high molecular weight long chain polyethylene braided with polyester, nylon or a bioabsorbable material. Selected nylon fibers in the cover are provided in a color contrasting with the other cover fibers to provide an identifiable trace. The cover surrounds a core formed of twisted strands of ultrahigh molecular weight polyethylene. The suture, provided in a #2 size, has the strength of #5 Ethibond, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: April 18, 2006
    Assignee: Arthrex, Inc.
    Inventors: R. Donald Grafton, Reinhold Schmieding
  • Patent number: 7026437
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: April 11, 2006
    Assignee: Poly-Med, INC
    Inventors: Shalaby W. Shalaby, Dan Åkerfeldt, Fredrik Preiniz, Per Egnelöv, Torbjörn Mathisen
  • Patent number: 7001410
    Abstract: Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: February 21, 2006
    Assignee: Biopsy Sciences, LLC
    Inventors: John S. Fisher, Frederick Ahari, Lucjan J. J. Hronowski
  • Patent number: 6994719
    Abstract: A high strength abrasion resistant surgical suture material with improved tie down characteristics is color coded for visualization and identification purposes. The suture features a multifilament cover formed of strands of ultra high molecular weight long chain polyethylene braided with polyester, nylon or a bioabsorbable material. Selected nylon fibers in the cover are provided in a color contrasting with the other cover fibers to provide an identifiable trace. The cover surrounds a core formed of twisted strands of ultrahigh molecular weight polyethylene. The suture, provided in a #2 size, has the strength of #5 Ethibond, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle. The identifiable trace preferably is provided along one half of the length of the suture, so that when the suture is loaded onto a suture anchor, for example, the two legs of the length of suture on either side of the suture anchor can be readily identified.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: February 7, 2006
    Assignee: Arthrex, Inc.
    Inventor: R. Donald Grafton
  • Patent number: 6977231
    Abstract: A suturable adhesion-preventing membrane has high suture strength, good biocompatibility, decomposition and absorption in a living body, sufficient adhesion-preventing effect, and desirable guided tissue regeneration. The membrane is composed of at least one non-woven fabric layer made of collagen fibers, or a laminated membranous substance consisting of at least one non-woven fabric layer made of collagen fibers and at least one sponge layer made of collagen, and a coating layer of gelatin or hyaluronic acid on the surface or surfaces of the above membrane. Preferably, the membrane comprises one to six compressed cross-linked collagen non-woven fabric layers wherein a layer has a fibers having a fiber diameter of 0.05 mm to 1.0 mm, a bulk density of 5.0×10?4 to 5 g/cm3 and a thickness of 0.1 mm to 50 mm, and a coating layer containing gelatin or hyaluronic acid and having a thickness of 0.05 mm to 20 mm, wherein the coating layer covers one or both sides or a part or whole of the surface of the membrane.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: December 20, 2005
    Assignee: Nipro Corporation
    Inventor: Kazuhisa Matsuda
  • Patent number: 6945985
    Abstract: A method for making a surgical article is provided which comprises exposing a bioabsorbable material, e.g., a copolymer derived from a major amount of glycolide and a minor amount of lactide, to a humid environment either prior to coating the material or prior to or following sterilization of the material for a time period and at a temperature sufficient to predegrade the resulting surgical article.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: September 20, 2005
    Assignee: Tyco Healthcare Group LP
    Inventors: John Kennedy, Mark S. Roby, Matthew E. Hain
  • Patent number: 6881766
    Abstract: Sutures fabricated from and/or coated with compositions including water-soluble glass are described herein. Pledgets containing water-soluble glass within the interstices of the pledget and/or coated with compositions including water-soluble glass are also described herein. The water-soluble glass optionally includes a therapeutic agent, e.g., silver to promote wound repair.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: April 19, 2005
    Assignee: Tyco Healthcare Group LP
    Inventor: Matthew Hain
  • Patent number: 6878757
    Abstract: Compositions with antimicrobial properties contain a fatty acid ester salt mixed with a bioabsorbable copolymer. These compositions are useful in forming coatings for surgical articles, including multifilament sutures.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: April 12, 2005
    Assignee: Tyco Healthcare Group LP
    Inventor: Mark Roby
  • Publication number: 20040267314
    Abstract: A method of wound closure comprising providing a gold suture and closing the laceration with the gold suture. The laceration is closed by: inserting the suture into the dermis and through the subcutaneous fat layer on one side of the laceration; inserting the suture at the base of the laceration; inserting the suture through the subcutaneous fat layer and into the dermis on the other side of the laceration to form a loop under the skin; repeating the steps in another insertion 3 to 5 mm from the loop in a continuous or interrupted manner to close the laceration; and tightening the suture line by applying tension to the loops to bring one side of the laceration into contact with the other side of the laceration.
    Type: Application
    Filed: June 25, 2003
    Publication date: December 30, 2004
    Inventors: Bradley R. Wolf, Igor A. Bogin, Ruben A. Bogin
  • Publication number: 20040267315
    Abstract: A braided suture for skin lifting comprising gold threads and bioabsorbable threads, wherein the gold threads and bioabsorbable threads are braided to form a braided composite suture. A method of skin lifting providing a braided composite suture comprising gold threads and bioabsorbable threads and implanting the braided composite suture intradermally at a plurality of skin regions.
    Type: Application
    Filed: June 25, 2003
    Publication date: December 30, 2004
    Inventors: Bradley R. Wolf, Igor A. Bogin, Ruben A. Bogin
  • Patent number: 6794484
    Abstract: The present invention is directed to absorbable polylactone copolymers prepared in part from about 2 to about 80 mole percent glycolide, utilizing a combination of a monofunctional polymerization initiator and a di-functional polymerization initiator, to achieve rates of crystallization of the copolymer of at least about 2 times faster than the rate of crystallization of a copolymer made by a similar process utilizing either the mono-functional or the di-functional polymerization initiator alone. Medical devices containing such copolymers are also disclosed.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: September 21, 2004
    Assignee: Ethicon, Inc.
    Inventors: Hugh D. Newman, Jr., Sasa Andjelic, Brian M. Kelly, Dennis D. Jamiolkowski, Rao S. Bezwada
  • Patent number: 6794485
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: September 21, 2004
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
  • Publication number: 20040133237
    Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.
    Type: Application
    Filed: October 9, 2003
    Publication date: July 8, 2004
    Inventor: Shalaby W. Shalaby
  • Patent number: 6747121
    Abstract: The present invention relates in general to implantable, resorbable copolymers containing L-lactide and glycolide repeat units, and in particular to terpolymers containing L-lactide, glycolide, and one other type of repeat unit selected from the group consisting of D-lactide, D,L-lactide, and &egr;-caprolactone. Medical devices for in vivo implantation applications containing such implantable, resorbable copolymers are also described, as well as methods for making such copolymers and devices.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: June 8, 2004
    Assignee: Synthes (USA)
    Inventor: Sylwester Gogolewski
  • Publication number: 20040106734
    Abstract: Polymer compositions comprising poly-glycolic acid (PGA) or a functional derivative thereof with a tensile strength of at least 1200 MPa are disclosed. Processes suitable for manufacturing said compositions are also described, comprising rendering PGA into an amorphous state then drawing to form a highly orientated polymer structure. The polymer compositions can be used to make artefacts, for example sutures, or used in combination with other polymers or non-polymeric substances to produce other artefacts, for example medical devices suitable for implantation into the human body. Processes for the production of said artefacts are also described.
    Type: Application
    Filed: September 25, 2003
    Publication date: June 3, 2004
    Inventor: John Rose
  • Patent number: 6743505
    Abstract: The present invention relates to a process of forming bioabsorbable, multifilament yarn from Lactide-rich copolymers, including the steps of extruding and spinning a Lactide-rich copolymer to form a spun multifilament yarn, pre-tensioning the spun multifilament yarn to form a pre-tensioned yarn, heating the pre-tensioned yarn to form a pre-tensioned, preheated yarn, annealing and drawing the pre-tensioned, preheated yarn for a first time, annealing and drawing the yarn for a second time, cooling the twice-drawn yarn to a lower temperature, and taking-up the cooled multifilament yarn, to yarns prepared by the process and to medical devices prepared from such yarns.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: June 1, 2004
    Assignee: Ethicon, Inc.
    Inventors: Attila Antal, Gaoyuan Chen, Dominick Egidio, Anthony Tiano, Edward Walker
  • Publication number: 20040098049
    Abstract: The present invention relates to a monofilament suture prepared by co-extruding polymers having different Young's moduli and to a process for preparing the same. The suture is prepared in such a form that a polymer having a high Young's modulus surrounds a polymer having a low Young's modulus. The monofilament suture prepared by the present invention has excellent knot security, flexibility and/or knot strength.
    Type: Application
    Filed: September 29, 2003
    Publication date: May 20, 2004
    Inventors: Jung-Nam Im, Jang-Il Seo, Chong-Taek Hong, Chaul-Min Pai, Hye-Sung Yoon
  • Patent number: 6712838
    Abstract: The present invention discloses a process for producing a braided suture having an improved knot strength comprising heating a braided suture coated with a low molecular weight biocompatible polymer to a temperature sufficient to melt the low molecular weight biocompatible polymer for a time sufficient to allow the low molecular polymer to be redistributed into the interstices of the braided suture thereby providing a coated braided suture with an improved knot tensile strength. Also disclosed is the coated braided suture having a low molecular weight polymer optimally dispersed throughout the braided suture's cross-section.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: March 30, 2004
    Assignee: Ethicon, Inc.
    Inventors: Margaret D'Aversa, Howard L. Scalzo, Jr., Dennis D. Jamiolkowski, Rao S. Bezwada, Donald G. Hill, Alastair W. Hunter
  • Patent number: 6706058
    Abstract: The invention relates to a coating material for medical treatment, particularly a wound contact material, of resorbable, synthetic material, which is formed from a terpolymer based on lactide, trimethylene carbonate and &egr;-caprolactone with a maximum lactide content of 85 wt. %, trimethylene carbonate in the range 5 to 20 wt. % and &egr;-caprolactone in the range 5 to 20 wt. %, a method for its manufacture and its use.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: March 16, 2004
    Assignee: Deutsche Institute fur Textil- und Faserforschung Stuttgart Stiftung des offentlichen Rechts
    Inventors: Helmut Hierlemann, Heinrich Planck
  • Patent number: 6703035
    Abstract: This invention deals with crystalline, nitrogen copolyester lubricant coating devices comprising sutures, wherein said lubricant comprises a triaxial copolyester chain with a central nitrogenous base or a copolyester with more than one carboxylic group ionically linked to a basic amino acid.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 9, 2004
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6689153
    Abstract: A coated/impregnated anchoring device and/or suture to prevent infection, deliver site specific drugs, and deliver human growth factors to the surgical site. The coatings can include anti-microbial agents to prevent or fight infection en route to and at the surgical site. The coatings can also include site specific drugs and/or human growth factors to fight infection, anesthetize tissue and/or bone en route and at the site, promote tissue regeneration, promote bone regeneration, and/or other desired medical processes.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: February 10, 2004
    Assignee: Orthopaedic Biosystems Ltd, Inc.
    Inventor: Jeffry B. Skiba
  • Publication number: 20030187476
    Abstract: The present invention relates to a monofilament suture prepared by co-extruding polymers having different Young's moduli and to a process for preparing the same. The suture is prepared in such a form that a polymer having a high Young's modulus surrounds a polymer having a low Young's modulus. The monofilament suture prepared by the present invention has excellent knot security, flexibility and/or knot strength.
    Type: Application
    Filed: August 13, 2002
    Publication date: October 2, 2003
    Inventors: Jung-Nam Im, Jang-Il Seo, Chong-Taek Hong, Hye-Sung Yoon, Chaul-Min Pai
  • Patent number: 6624097
    Abstract: An implantable medical article as well as an implantable fiber which is particularly useful for medical implants is disclosed. The fiber includes comprises a first component formed from a substantially resorbable material and a second component formed from a fiber-forming polymer.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: September 23, 2003
    Assignee: Solutia Inc.
    Inventors: Donald H. Martin, John H. Southern
  • Patent number: 6616687
    Abstract: The present invention relates to a coating material for surgical sutures which comprises as essential ingredients a copolymer having repeating units of lactic acid and &egr;-caprolacton and calcium stearate; and a surgical suture comprising a lactic acid/&egr;-caprolacton copoymer in which a lactide/&egr;-caprolacton ratio is (70-85 mol %)/(30-15 mol %) and the number of &egr;-caprolacton repeating unit is 2.5 or greater on the average.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: September 9, 2003
    Assignee: Gunze Limited
    Inventors: Kenji Tomihata, Masakazu Suzuki, Ikuo Sasaki
  • Patent number: 6607548
    Abstract: A novel polymer composition is provided which includes a base material including a biodegradable polymer or copolymer, and a copolymer additive including one or more monomers imparting a tensile strength to the polymer composition at room temperature that is lower than a tensile strength at room temperature for the base material.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: August 19, 2003
    Assignee: Inion Ltd.
    Inventors: Timo Pohjonen, Harri Happonen, Pertti Helevirta, Auvo Kaikkonen, Jan Nieuwenhuis, Piet E. Haers, Hermann Sailer
  • Patent number: 6605294
    Abstract: Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: August 12, 2003
    Assignee: Incept LLC
    Inventor: Amarpreet S. Sawhney
  • Publication number: 20030078617
    Abstract: Unitary surgical devices are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors connected to fixed lengths suture. The anchors and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms connected to a base prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base or supported on the base. The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus.
    Type: Application
    Filed: July 15, 2002
    Publication date: April 24, 2003
    Inventors: Herbert E. Schwartz, Prasanna Malaviya, Amit K. Singla, Pamela Lynn Plouhar, Mark Joseph Pelo
  • Publication number: 20030023209
    Abstract: A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide include bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatable surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF-&bgr; activity is also provided.
    Type: Application
    Filed: January 25, 2002
    Publication date: January 30, 2003
    Applicant: United States Surgical Corporation
    Inventors: Elliott A. Gruskin, Christofer T. Chistoforou
  • Patent number: 6503991
    Abstract: The present invention is directed to crystalline, absorbable block/segmented copolymers which are the reaction product of a linear prepolymer which is a polytrimethylene dicarboxylate of succinic, glutaric, or adipic acid and either glycolide, 1-lactide, or mixtures thereof. Preferably the prepolymer is preliminarily end-grafted with a further monomer such as trimethylene carbonate or &egr;-caprolactone. The crystalline copolymers of this invention are tailored for fabrication into several forms of absorbable biomedical devices including monofilament sutures.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: January 7, 2003
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6498229
    Abstract: The present invention is directed to a method for the direct, one-step synthesis of crystalline segmented glycolide copolymers having less than 80 percent glycolide-based sequences in the copolyester chain. The copolyester chain can also be formed using a polyether glycol as the initiator for the ring-opening copolymerization of glycolide and other cyclic monomers to form highly hydrophilic materials.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: December 24, 2002
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6494898
    Abstract: A synthetic absorbable monofilament comprising glycolide and epsilon caprolactone is provided. The monofilament exhibits physical characteristics equivalent to or superior than gut sutures. The monofilaments can be fabricated into a wide variety of surgical devices such as sutures, meshes, and the like.
    Type: Grant
    Filed: September 26, 1998
    Date of Patent: December 17, 2002
    Assignee: United States Surgical Corporation
    Inventors: Mark S. Roby, Ying Jiang, Lyudmila K. Kokish