Absorbable In Body Patents (Class 606/230)
  • Patent number: 5695879
    Abstract: A surgical suture material of absorbable, synthetic polymer is formed from glycolide-trimethylene carbonate copolymer with a glycolide content higher than 76 wt. % and with a statistical distribution of the monomers. Within 9 to 21 days, the suture material has a complete breaking strength loss and is completely absorbed in vivo after 35 to 91 days.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: December 9, 1997
    Assignee: B. Braun Surgical GmbH
    Inventors: Helmut Goldmann, Helmut Hierlemann, Erhard Mueller, Heinrich Planck
  • Patent number: 5690675
    Abstract: Wounds in lung tissue are closed in a two step method consisting essentially of applying fasteners to a region adjacent to the wound, wherein the fasteners may cause penetrations. The fasteners are present in a preformed layer of collagen, fibrin, fibrinogen, elastin, albumin, or a combination thereof, and energy is applied to the region to fuse the material to the tissue and seal perforations in the tissue.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 25, 1997
    Assignee: Fusion Medical Technologies, Inc.
    Inventors: Philip N. Sawyer, Philip M. Sawyer, Cary J. Reich
  • Patent number: 5683417
    Abstract: A suture for particular use in endoscopic surgery includes a distal end needle, a preferably braided suture body, and a bulbous proximal end. The method includes stitching the tissue, then passing the needle/distal end through the bulbous proximal end, where the body of the suture is held frictionally or adhesively under proper tension.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: November 4, 1997
    Inventor: William I. Cooper
  • Patent number: 5662682
    Abstract: A suture is provided with a solid spiroid braid construction. The suture exhibits greater flexibility, better hand and less chatter and drag than tubular braided sutures of known construction.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: September 2, 1997
    Assignee: United States Surgical Corporation
    Inventors: Michael P. Chesterfield, Ilya Koyfman, Matthew E. Hain
  • Patent number: 5660854
    Abstract: A surgical implant or external wound dressing which functions as both a hemostat and a device to safely and effectively deliver any of a number of pharmaceuticals to targeted tissue at a controlled rate is disclosed. The device generally comprises a carrier in the form of fibers, sutures, fabrics, cross-linked solid foams or bandages, a pharmaceutical in solid micoparticulate form releasably bound to the carrier fibers, and a lipid adjuvant which aids the binding of the microparticles to the fibers as well as their function in the body.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: August 26, 1997
    Inventors: Duncan H Haynes, Ben H. Bodeker, Mark D. Kline
  • Patent number: 5633343
    Abstract: Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers glycolide, and p-dioxanone are described. The segmented copolymers exhibit a broad range of properties, especially high strength and stiffness, and fast absorption rates and breaking strength retention (BSR) profiles, useful in a variety of medical devices. Most importantly, for suture applications where Vicryl.RTM.-like polyglcolide-polylactide sutures with excellent tensile properties, but shorter BSR profiles than Vicryl.RTM. are needed. The copolymers of the present invention have such properties, making them useful in plastic surgery where faster absorption times would lead to less tissue scarring.
    Type: Grant
    Filed: June 30, 1995
    Date of Patent: May 27, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Kevin Cooper, Dennis D. Jamiolkowski, Hugh D. Newman, Jr.
  • Patent number: 5626611
    Abstract: The present invention relates to composite materials having a core portion formed from a first bioabsorbable material and at least one shell portion of a second bioabsorbable material joined to the core portion. The first and second bioabsorbable materials have different rates of bioabsorption. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The materials of the present invention may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: May 6, 1997
    Assignee: United States Surgical Corporation
    Inventors: Cheng-Kung Liu, Ying Jiang, Mark S. Roby, Steven L. Bennett, Richard P. Stevenson, Jeffrey P. Pietrangeli
  • Patent number: 5621050
    Abstract: This invention relates to materials for medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk properties, but inappropriate frictional properties. This invention also relates to a hydrophilic coating material that provides improved frictional properties.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 15, 1997
    Assignee: American Cyanamid Company
    Inventors: Peter K. Jarrett, George Jessup, Louis Rosati, Chris Martin, John W. Maney
  • Patent number: 5618313
    Abstract: Absorbable copolymers are fabricated from a predominant component of dioxanone randomly copolymerized with minor amounts of other bioabsorbable monomers. The copolymers are useful in forming surgical articles, including both monofilament and multifilament sutures.
    Type: Grant
    Filed: October 11, 1994
    Date of Patent: April 8, 1997
    Assignee: United States Surgical Corporation
    Inventors: Mark S. Roby, Donald S. Kaplan, Cheng-Kung Liu, Steven L. Bennett
  • Patent number: 5584857
    Abstract: A coating and tubing fluid for sutures, especially gut sutures, is provided. The coating composition includes linseed oil, an organic solvent and a catalyst. The tubing fluid includes water, a softening agent, a C.sub.2 -C.sub.4 alcohol and a lubricant of fatty acids, fatty acid alcohols and/or triglycerides of fatty acids. Gut sutures coated with the coating composition may be stored or packaged in the tubing fluid to provide sutures with improved flexibility, pliability, run-down performance and superior resistance to fraying and breaking.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: December 17, 1996
    Assignee: United States Surgical Corporation
    Inventors: Nagabhushanam Totakura, Shalaby W. Shalaby, Lyudmila Kokish
  • Patent number: 5584877
    Abstract: An antibacterial vascular prosthesis obtained by winding a tube, fiber or sheet formed from a polymeric material and combined with an antibacterial substance on the outer surface of a vascular prosthesis composed of a tubular porous body formed of a synthetic resin is provided. The antibacterial vascular prosthesis can exhibit an antibacterial activity over a long period of time without impairing the porous structure, antithrombogenicity and histocompatibility inherent in the vascular prosthesis composed of the tubular porous body formed of the synthetic resin. An antibacterial surgical suture comprising a tube or fiber formed from a polymeric material and combined with an antibacterial substance is also provided.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: December 17, 1996
    Assignee: Sumitomo Electric Industries, Ltd.
    Inventors: Shinichi Miyake, Shigehiko Ito, Yumiko Oka, Jun-ichi Kambayashi, Kazuhiro Okahara
  • Patent number: 5584859
    Abstract: A suture assembly made of bioabsorbable material is disclosed having a central body member with a plurality of elongated lateral members in a plane extending perpendicularly on each side therefrom and interconnected to the central body member by elastic connectors, each lateral member having a plurality of barb members extending at an acute angle therefrom, for the lateral members to be inserted laterally into two sides of a cut in body tissue, stretching the elastic connectors so that after insertion the two sides of the cut are joined at the incision junction around or above the central body member and are retained securely and non-withdrawably in the body tissue by the barb members on such lateral members, with such lateral members and attached body tissue being pulled toward the central body member by the contracting action of the elastic connectors. Also disclosed is a method for utilizing the suture assembly of this invention.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: December 17, 1996
    Inventor: Gregory R. Brotz
  • Patent number: 5569302
    Abstract: A multifilament surgical suture has an end portion tipped with cyanoacrylate resin. The suture can also include filling agents and lubricants which are incorporated into the suture prior to the suture being tipped. A typical filling agent is glycerol. A typical lubricant includes a copolymer of glycolide and lactide. Tipping is accomplished by passing a portion of the suture through a mist of monomeric cyanoacrylate resin and allowing the resin to harden by curing. The tipped portion may then be cut to create a tipped end for insertion into a surgical needle.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: October 29, 1996
    Assignee: United States Surgical Corporation
    Inventors: George R. Proto, Francis D. Colligan, Harold Bellmore, Jr.
  • Patent number: 5554170
    Abstract: Block copolymers wherein one of the blocks is made from hard phase forming monomers and another of the blocks is made from soft phase forming monomers copolymerized with randomly intermingled units of other soft phase forming monomers. The copolymers are useful in forming surgical articles, including both monofilament and multifilament sutures.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: September 10, 1996
    Assignee: United States Surgical Corporation
    Inventors: Mark S. Roby, Steven L. Bennett, Cheng-Kung Liu
  • Patent number: 5540717
    Abstract: A higher order polyamide monofilament suture exhibits improved properties such as greater resistance to creep, greater knot security and greater chemical stability in aqueous environments.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: July 30, 1996
    Assignee: U.S. Surgical Corporation
    Inventors: Cheng-Kung Liu, John C. Brewer
  • Patent number: 5531761
    Abstract: Suture devices, particularly useful in endoscopic surgery, include a suture device made of bioabsorbable material having an elongate body member with a sharp distal end for penetrating tissue and means for locking the suture device in tissue to prevent forward and rearward movement and a suture device made of bioabsorbable material having a hinge-like joint for folding a distal portion at a precise location to be juxtaposed with a proximal portion for adjustable locking. Methods of using the suture devices for joining tissue sections, such as in tuboplasty, for closing anatomical lumens and for subcuticular suturing.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: July 2, 1996
    Inventor: Inbae Yoon
  • Patent number: 5530074
    Abstract: This invention relates to materials for medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk properties, but inappropriate frictional properties. This invention also relates to a hydrophilic coating material that provides improved frictional properties.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 25, 1996
    Assignee: American Cyanamid Company
    Inventors: Peter K. Jarrett, George Jessup, Louis Rosati, Chris Martin, John W. Maney
  • Patent number: 5525706
    Abstract: A nonwoven fabric comprised of a lactide polymer. The lactide polymer comprises a plurality of poly(lactide) polymer chains, residual lactide in concentration of less than about 2 percent and water in concentration of less than about 2000 parts-per-million. A process for manufacturing a nonwoven fabric with the lactide polymer composition is also disclosed.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: June 11, 1996
    Assignee: Cargill, Incorporated
    Inventors: Patrick R. Gruber, Jeffrey J. Kolstad, Christopher M. Ryan, Eric S. Hall, Robin S. Eichen Conn
  • Patent number: 5522841
    Abstract: Block copolymers have one of the block made from hard phase forming monomers and another block made from soft phase forming monomers copolymerized with randomly intermingled units of other soft phase forming monomers. Particularly useful copolymers are initiated with a polyalkylene oxide initiator. The copolymers are useful in forming surgical articles, including both monofilament and multifilament sutures.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: June 4, 1996
    Assignee: United States Surgical Corporation
    Inventors: Mark S. Roby, Cheng-Kung Liu, Steven L. Bennett
  • Patent number: 5522842
    Abstract: Crystalline, low melting .epsilon.-Caprolactone polymers which undergo accelerated hydrolysis for use, for example, as absorbable coatings for surgical sutures; the polymers bearing basic amine functionalities, ionically or covalently linked to the ester chain, which induce autocatalyzed hydrolysis.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: June 4, 1996
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 5521280
    Abstract: A composition of an absorbable polymer and a filler to increase the stiffness of the polymer is disclosed. The filler is a poly[succinimide], which is a bioabsorbable polymer that degrades into a nontoxic, simple amino acid. The composition can be melt processed to prepare medical and surgical devices, particularly those devices which are designed to penetrate bodily tissue or to withstand heavy loads. Typical surgical devices which can be made from the composition include surgical staples and ligating clips.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: May 28, 1996
    Assignee: Ethicon, Inc.
    Inventors: Eugene P. Reilly, Steven C. Arnold, Angelo G. Scopelianos
  • Patent number: 5502159
    Abstract: A block copolymer for use in the fabrication of bioabsorbable articles such as monofilament surgical sutures is prepared by copolymerizing one or more hard phase forming monomers and 1,4-dioxan-2-one, and then polymerizing one or more hard phase forming monomers with the dioxanone-containing copolymer.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: March 26, 1996
    Assignee: United States Surgical Corporation
    Inventors: Cheng-Kung Liu, Steven L. Bennett, John Kennedy, Donald S. Kaplan, Ross R. Muth
  • Patent number: 5486593
    Abstract: This invention relates to medical devices formed totally or in part from homopolymers or copolymers comprising recurring carbonate moieties.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: January 23, 1996
    Assignee: United States Surgical Corporation
    Inventors: Regianld T. Tang, Frank Mares, William J. Boyle, Jr., Tin-Ho Chiu, Kundanbhai M. Patel
  • Patent number: 5483009
    Abstract: A moldable and/or extrudable polymer which is useful for the manufacture of surgical devices such as sutures, staples, clips, etc., possesses structural units derived from a cyclic amide monomer containing oxygen, sulfur or nitrogen in the ring.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: January 9, 1996
    Assignee: United States Surgical Corporation
    Inventor: Ying Jiang
  • Patent number: 5480961
    Abstract: Bioabsorbable polymers are obtained from the polymerization of cyclic ether-esters which are derived from crown ethers. The bioabsorbable polymers are useful in forming surgical articles including sutures and suture coating compositions.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: January 2, 1996
    Assignee: United States Surgical Corporation
    Inventors: Ying Jiang, John S. Bobo
  • Patent number: 5480411
    Abstract: A method for suturing a wound using a suture manufactured from polyamide ester having the reaction product of at least one molecular weight diols; at least one dicarboxylic acids and at least one polyoxyalkylene diimide diacid to create a wound closure.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: January 2, 1996
    Assignee: United States Surgical Corporation
    Inventors: Cheng-Kung Liu, John C. Brewer
  • Patent number: 5478355
    Abstract: A method is provided for improving the in vivo strength retention of a bioabsorbable implantable medical device such as a suture.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: December 26, 1995
    Assignee: United States Surgical Corporation
    Inventors: Ross R. Muth, Nagabhushanam Totakura, Cheng-Kung Liu
  • Patent number: 5470340
    Abstract: A copolymer of p-dioxanone and a prepolymer of p-dioxanone and lactide and/or glycolide, and absorbable surgical devices such as sutures, surgical meshes, surgical staples, hemostatic clips, suture knot clips, and the like made therefrom.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: November 28, 1995
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Shalaby W. Shalaby, Donald F. Koelmel
  • Patent number: 5468253
    Abstract: Medical devices or components for medical devices formed from bioabsorbable elastomers comprising a random copolymer are disclosed. The random copolymer is a copolymer of from about 30 to about 70 weight percent of: a) .epsilon.-caprolactone, trimethylene carbonate, an ether lactone, or a mixture of these, and b) the balance being substantially glycolide, para-dioxanone, or a mixture of these. The random copolymers surprisingly exhibit elastomeric properties, and the copolymers are bioabsorbable. The combination of physical and biological properties of these elastomeric copolymers are particularly well-suited for numerous medical and surgical applications.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: November 21, 1995
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Angelo G. Scopelianos
  • Patent number: 5454834
    Abstract: A surgical suture material is provided with a thread (1) and, in some cases, a needle (2) to allow formation of a knot with the greatest possible security while expending little effort, even in situations where space is limited--for example, during an endoscopic operation. The suture material has at least one inherently stable coil, loop or similar preformed feature in at least one initial preformed section (3,4) of its length. Another section of the thread (1) or an end of the thread can be threaded or guided through this preformed feature for the purpose of forming a loop and/or knot. The preformed section can take the form of a preformed feature with an approximately spiral shape, for example.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: October 3, 1995
    Assignee: Richard Wolf GmbH
    Inventors: Manfred Boebel, Bernd Klemm
  • Patent number: 5454833
    Abstract: A system for obturating an orifice in a perforated organ or vessel such as a vessel having undergone an operation. In the system a deformable obturator element capable of being introduced in a deformed state inside a member through the orifice is used. In a position of use the obturator element has a substantially flat face that is applied in a tight manner on an inner face of the organ or vessel. The obturator element has a first portion of wire unwindable by pulling from its center. The system also uses an extractor element that consists of a second portion of wire extending from substantially the center of the obturator element. The extractor element is used to bring the flat face into contact with the inner face of the organ. After the orifice has been obturated the extractor element is used to remove the obturator element from the orifice.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: October 3, 1995
    Assignee: Laboratoire, Nycomed S.A.
    Inventors: Georges Boussignac, Pierre Hilaire, Pascal Pendaries
  • Patent number: 5442032
    Abstract: This invention provides various copolymers comprising a repeating unit of the chemical formula:(CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CO.sub.2)and other repeating units having a chemical formula selected from the group consisting of:(CHRCO.sub.2),([CH.sub.2 ].sub.5 CO.sub.2),(CH.sub.2 CH.sub.2 OCH.sub.2 CO.sub.2),(CH.sub.2 CH.sub.2 CH.sub.2 OCO.sub.2), andcombinations of two or mope thereof wherein R is a hydrogen atom or a methyl group and the first repeating unit is less than 45 weight percent of the total weight of the copolymer. This invention also relates to use of these copolymers in the fabrication of absorbable surgical devices such as sutures and as coatings for medical devices.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: August 15, 1995
    Assignee: Ethicon, Inc.
    Inventors: Steven C. Arnold, Rao S. Bezwada, Alastair W. Hunter
  • Patent number: 5442016
    Abstract: This invention relates to materials for medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk properties, but inappropriate frictional properties. This invention also relates to a hydrophilic coating material that provides improved frictional properties.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: August 15, 1995
    Assignee: American Cyanamid Company
    Inventors: Peter K. Jarrett, George Jessup, Louis Rosati, Chris Martin, John W. Maney
  • Patent number: 5431679
    Abstract: Block copolymers wherein one of the blocks is made from hard phase forming monomers and another of the blocks is made from soft phase forming monomers copolymerized with randomly intermingled units of other soft phase forming monomers. The copolymers are useful in forming surgical articles, including both monofilament and multifilament sutures.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: July 11, 1995
    Assignee: United States Surgical Corporation
    Inventors: Steven L. Bennett, Cheng-Kung Liu
  • Patent number: 5425747
    Abstract: A suture made of bioabsorbable material is disclosed having a central body member with a plurality of lateral members extending perpendicularly therefrom and in the same general plane with the central body member, each lateral member having a plurality of barb members extending at an acute angle therefrom, allowing the lateral members to be inserted laterally into two sides of a cut in body tissue so that the two sides are joined at an incision junction at the central body member and are retained securely and non-withdrawably in the body tissue by the barb members on such lateral members. Also disclosed is a method for utilizing the suture of this invention.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: June 20, 1995
    Inventor: Gregory R. Brotz
  • Patent number: 5425984
    Abstract: A bioabsorbable fiber useful for the manufacture of medical devices is obtained from a polymer containing from about 15 to about 30 mole percent glycolide in a melt spinning operation carried out under low shear conditions. The fiber is drawn at a ratio of about 1.5 to 2.7. The fiber possesses excellent tensile strength and a high level of retention of its original strength on storage.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: June 20, 1995
    Assignee: United States Surgical Corporation
    Inventors: John Kennedy, Cheng-Kung Liu
  • Patent number: 5425949
    Abstract: A bioabsorbable copolymer is obtained from the polymerization of a major amount of .epsilon.-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of an initiator possessing at least two carboxylic acid groups. The copolymer is useful, inter alia, as a coating for a surgical suture.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: June 20, 1995
    Assignee: United States Surgical Corporation
    Inventors: Steven L. Bennett, Mark S. Roby, Ross R. Muth
  • Patent number: 5423859
    Abstract: A bioabsorbable surgical suture which includes at least one multifilament yarn having at least one portion wherein the filaments of the yarn are entangled. The suture has a core formed by combining a length of the entangled yarn with a length of at least one other entangled yarn to form a plied yarn which is then entangled and twisted in a particular direction. This entangled and twisted yarn is then combined with another entangled and twisted yarn, both yarns having been twisted in the same direction. The combined yarns are then twisted together in the opposite direction to form a suture core.
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: June 13, 1995
    Assignee: United States Surgical Corporation
    Inventors: Ilya Koyfman, Michael P. Chesterfield
  • Patent number: 5412068
    Abstract: This invention relates to medical devices formed totally or in part from homopolymers or copolymers comprising recurring carbonate moieties.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: May 2, 1995
    Assignee: United States Surgical Corporation
    Inventors: Reginald T.-H. Tang, Frank Mares, William J. Boyle, Jr., Tin-Ho Chiu, Kundanbhai M. Patel
  • Patent number: 5403347
    Abstract: Block copolymers wherein one of the blocks is made from hard phase forming monomers and another of the blocks is made from soft phase forming monomers copolymerized with randomly intermingled units of other soft phase forming monomers. The copolymers are useful in forming surgical articles, including both monofilament and multifilament sutures. The block copolymer preferably comprising:a) a proportion of glycolic acid ester units as end blocks, andb) a center block comprising 1,4 dioxan-2-one randomly polymerized with 1,3 dioxane-2-one.
    Type: Grant
    Filed: March 2, 1994
    Date of Patent: April 4, 1995
    Assignee: United States Surgical Corporation
    Inventors: Mark S. Roby, Steven L. Bennett, Cheng-Kung Liu
  • Patent number: 5391707
    Abstract: Processes of producing 1,4-dioxan-2-one (p-dioxanone) are improved by the addition of a blocking agent to a crude reaction product containing p-dioxanone. The blocking agent reacts with unreacted starting materials in the crude reaction product to protect the active sites thereon with groups that do not initiate polymerization of p-dioxanone. The polymerization of p-dioxanone before its recovery from the process is thereby inhibited.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: February 21, 1995
    Assignee: United States Surgical Corporation
    Inventor: Ying Jiang
  • Patent number: 5380780
    Abstract: Absorbable coating and absorbable blend of polycaprolactone and crystallization modifier especially suitable for use in the coating of surgical sutures and in the controlled release of chemical or pharmaceutical agents.
    Type: Grant
    Filed: September 14, 1992
    Date of Patent: January 10, 1995
    Assignee: Deknatel Technology Corporation, Inc.
    Inventor: James R. Olson
  • Patent number: 5378540
    Abstract: Absorbable coating and absorbable blend of polycaprolactone ant crystallization modifier especially suitable for use in the coating of surgical sutures and in the controlled release of chemical or pharmaceutical agents.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: January 3, 1995
    Assignee: Deknatel Technology Corporation, Inc.
    Inventor: James R. Olson
  • Patent number: 5376102
    Abstract: A deformable surgical repair device is manufactured from a block or graft copolymer. The copolymer comprises a plurality of first linkages selected from the group consisting of glycolic acid ester and lactic acid ester linkages, and mixtures thereof, and a plurality of second linkages selected from the group consisting of 1,3-dioxan-2-one; 1,4-dioxan-2-one and .epsilon.-caprolactone linkages. The plurality of first linkages comprises at least about 50 up to about 90 mole percent of the copolymer. In an alternative Claim, the deformable surgical repair device is manufactured from a blend of a first and a second absorbable polymer. The first absorbable polymer comprises a plurality of linkages selected from the group consisting of glycolic acid ester and lactic acid ester linkages, and mixtures thereof. The second absorbable polymer comprises a plurality of linkages selected from the group consisting of 1,3-dioxan-2-one; 1,4-dioxan-2-one and .epsilon.-caprolactone linkages.
    Type: Grant
    Filed: January 13, 1992
    Date of Patent: December 27, 1994
    Assignee: American Cyanamid Co.
    Inventors: Peter K. Jarrett, Donald J. Casey
  • Patent number: 5376118
    Abstract: A support material for cell impregnation is provided. The support material is fabricated from a semiabsorbable composite yarn comprising a nonabsorbable, elastic core yarn and an absorbable, relatively inelastic sheath yarn. A prosthetic device may be formed from the support material. The support material is impregnated with living cells followed by incorporation into the tissue structure of a host organism. The support material impregnated with cells may be cultured in vitro to increase the number of cells prior to incorporation into the host organism.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: December 27, 1994
    Assignee: United States Surgical Corporation
    Inventors: Donald S. Kaplan, John Kennedy, Ross R. Muth, Elliot A. Gruskin
  • Patent number: 5374268
    Abstract: A device for repairing torn tissue or muscle such as the meniscus of the knee. The device consists of a pair of needles detachably secured to a pair of anchoring members having a plurality of barb-like projections extending outwardly therefrom. The anchoring members are joined by a suture which connects the ends of the anchoring members opposite the needles.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: December 20, 1994
    Assignee: United States Surgical Corporation
    Inventor: Thomas Sander
  • Patent number: 5352515
    Abstract: This invention relates to materials medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk properties, but inappropriate frictional properties. This invention also relates to a hydrophilic coating material that provides improved frictional properties.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: October 4, 1994
    Assignee: American Cyanamid Company
    Inventors: Peter K. Jarrett, George Jessup, Louis Rosati, Chris Martin, John W. Maney
  • Patent number: 5349047
    Abstract: Polyesters having predetermined monomeric sequence are produced by stepwise addition of monomeric hydroxyacids to a growing polymeric chain. Included herein are various polyesters having predetermined primary sequence, various methods of producing polyesters having predetermined primary sequence, various articles formed from polyesters having predetermined primary sequence and various methods of using such articles.
    Type: Grant
    Filed: June 16, 1993
    Date of Patent: September 20, 1994
    Assignee: United States Surgical Corporation
    Inventors: Matthew E. Hermes, Bin Huang
  • Patent number: 5342376
    Abstract: An inserting device is disclosed for positioning a barbed tissue connector in tissue to close a wound. The barbed tissue connector is of a type which includes a generally rigid elongated body having a pointed leading end and a plurality of axially spaced barbs on the elongated body. The inserting device comprises a tubular body which is adapted to receive the connector therein with the pointed leading end of the connector protruding from an open leading end of the tubular body. The inserting device and the connector contained therein are positioned in tissue such that at least one of the barbs on the connector is engaging tissue, and the device is then retracted from the tissue, leaving the connector in place.
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: August 30, 1994
    Assignee: Dermagraphics, Inc.
    Inventor: Gregory L. Ruff
  • Patent number: 5338822
    Abstract: A lactide polymer composition combining compositional and purity limitations and catalyst optimization or addition of stabilizing agents resulting in a melt-stable polymer is disclosed. The melt-stable lactide polymer comprises a plurality of polylactide polymer chains, residual lactide in concentration of less than 2 percent and water in concentration of less than 1000 parts-per-million. A stabilizing agent in an amount sufficient to reduce depolymerization of the lactide polymer during melt-processing or alternatively, control of catalyst level at a molar ratio of monomer to catalyst greater than 3000:1 is also included in the melt-stable composition. A process for manufacture of a melt-stable lactide polymer composition includes polymerizing a lactide mixture and adding stabilizing agents sufficient to reduce depolymerization of the polylactide during melt-processing, followed by devolatilizing the polylactide to remove monomer and water.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: August 16, 1994
    Assignee: Cargill, Incorporated
    Inventors: Patrick R. Gruber, Jeffrey J. Kolstad, Eric S. Hall, Robin S. Eichen Conn, Christopher M. Ryan