Abstract: Devices, systems and methods are disclosed for treating or preventing a stroke and/or a transient ischemic attack in a patient. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. Vagus nerve stimulation is used to modulate the release of GABA, norepinephrine, and/or serotonin, thereby providing neuroprotection to the patient; to modulate the activity of resting state neuronal networks, particularly the sensory-motor network or resting state networks containing the insula; and to avert a stroke or transient ischemic attack that has been forecasted.

Abstract: Trigeminal nerves are stimulated based upon pulse counting and chronobiology. A cutaneous electrode assembly is applied to the forehead to stimulate the ophthalmic nerves. A method may include determining a number of pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves with the determined number of pulses. Another method may include determining a pulse repetition frequency for pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves at the pulse repetition frequency.

Abstract: A windowed electrode assembly includes a foam layer having windows. Each window receives a corresponding gel pad that is sized such that it is contained by the window's sidewalls. The windowed electrode assembly includes a foam backing layer that forms a back wall for the windows such that each gel pad is encased by the window's sidewalls and back wall.

Abstract: An example of a system may include an electrode arrangement, a neural modulation generator configured to use electrodes in the electrode arrangement to generate a modulation field, a communication module configured to receive commands, a memory configured to store modulation field parameter data, and a controller configured to control the neural modulation generator to generate the modulation field. The controller may be configured to implement a trolling routine to troll the modulation field through neural tissue positions, and implement a marking routine multiple times as the modulation field is trolled through the neural tissue positions to identify when the modulation field provides patient-perceived modulation.

Abstract: A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes, a user interface configured for receiving input from a user that selects one of a plurality of different shapes of a modulating signal and/or selects one of a plurality of different electrical pulse parameters of an electrical pulse train, neuromodulation output circuitry configured for outputting an electrical pulse train to the plurality of electrical terminals, and pulse train modulation circuitry configured for modulating the electrical pulse train in accordance with the selected shape of the modulating signal and/or selected electrical pulse parameter of the electrical pulse train.

Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.

Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.

Abstract: Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient's spinal cord.

Abstract: An example of a system for applying neuromodulation to a patient includes a modulation output circuit and a modulation control circuit. The modulation output circuit may be configured to deliver dorsal horn stimulation. The modulation control circuit may be configured to control the delivery of the dorsal horn stimulation by executing a neuromodulation algorithm using modulation parameters. The modulation control circuit may include a response input and a parameter calibrator. The response input may be configured to receive response information indicative of one or more responses to the stimulation of the dorsal horn. The parameter calibrator may be configured to adjust one or more of the modulation parameters using the response information.

Abstract: Some implementations provide a method for treating craniofacial pain in a patient, the method including: placing a wirelessly powered passive device through an opening into a target site in a head or neck region of the patient's body, the wirelessly powered passive device configured to receive an input signal non-inductively from an external antenna; positioning the wirelessly powered passive device adjacent to or near a nerve at the target site; and causing neural modulation to the nerve through one or more electrodes on the wirelessly powered passive device.

Abstract: A spinal cord modulation system is disclosed. While in one embodiment the system is used for the treatment of pain, other embodiments are also provided. In particular embodiments, the spinal cord modulation system generates and delivers an electrical therapy signal at a frequency in the range of from about 5 kHz to about 15 kHz to address pain without creating unwanted sensory and/or motor side effects. The system may further include various signal delivery devices to deliver the therapy signal to a patient's spinal cord region.

Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.

Abstract: A neuromodulation device is configured with a set of testing program configuration instructions including therapeutic neuromodulation field-setting parameters. The device determines a custom priming program in response to the testing program configuration instructions. The custom priming program controls the neuromodulation device to generate a priming field with specific correspondence to the therapeutic neuromodulation field to be produced by the testing program.

Abstract: An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to generate a user interface to receive a therapy efficacy indication from a human subject for an neurostimulation treatment, receive user input in the user interface to select a therapy efficacy indication of the neurostimulation treatment, and identify a modification to a neurostimulation program based on the user input. For example, a therapy efficiency indication received in the user interface may indicate a perceived stimulation intensity, a perceived pain level, and a perceived location characteristic of the neurostimulation treatment. Based on the therapy efficacy indication and other user input in the graphical user interface, an updated setting to modify a parameter setting and implement a change to the neurostimulation treatment with a neurostimulation device can be provided.

Abstract: Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor ?B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.

Abstract: A programming-device user interface may include multiple levels of abstraction for programming treatment settings. A stimulation zone-programming interface may be at a highest level of abstraction and may include idealized stimulation zones. A field strength-programming interface may be at a middle level of abstraction and may include electromagnetic field-strength patterns generated by the stimulation zones, and/or electrode settings, and a depiction of how the electromagnetic fields interact with each other. An electrode-programming interface may be at a lowest level of abstraction and may depict treatment settings at an electrodes-view level. These interfaces may include a display of a stimulatable area of the patient's body. The display may include a depiction of leads and/or the underlying physiology, such as a depiction of a portion of a spine. Algorithms map treatment settings from one level of abstraction to settings at one or more other levels of abstraction.

Abstract: The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve or the pulmonary branches of the vagus nerves. The signal is able to treat bronchoconstriction and prevent and/or ameliorate bronchoconstriction.

Abstract: A method of operating an implantable neuromodulator coupled to an electrode array implanted adjacent tissue of a patient having a medical condition comprises conveying electrical modulation energy to tissue of the patient in accordance with a modulation parameter set, wherein conveying the electrical modulation energy to tissue of the patient in accordance with the modulation parameter set stimulates dorsal horn neuronal elements more than dorsal column neuronal elements.

Abstract: A device is provided for stimulating neurons that includes an implantable stimulation unit that generates stimuli in multiple stimulation elements. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation elements. Moreover, the device includes a control unit that controls the stimulation unit to repeatedly generates sequences of the stimuli with the order of the stimulation elements in which stimuli are generated within a sequence being constant for 20 or more successively generated sequences before it is varied.

Abstract: A method for treating pain or discomfort in a patient is disclosed. The method comprises stimulating a cranial nerve with an electrical signal. The pain or discomfort may be a withdrawal symptom. The cranial nerve may be in an auricular area of the patient. The cranial nerve may be cranial nerve V, cranial nerve VII, cranial nerve IX, cranial nerve X, or branches of greater and lesser occipital nerves thereof and their associated neurovascular bundles. The withdrawal symptom may result from cessation of an opioid. The method may further comprise administering a secondary drug treats one or more of the withdrawal symptoms and addiction. The secondary drug may be administered about one day to about one week after initiating the stimulating step.

Abstract: A regenerative interface electrode comprising a multilayer or sandwiched stack of dies that are oriented at their distal ends with at least one layer inset such that it forms a groove into which a nerve may be positioned inside the groove. The die layers include electrodes that connect to the nerve, allowing the nerve to be modulated. The electrodes in the die layers are connected to a PCB, which may communicate with a recording device. The distal end of the sandwiched die layers forming the groove is inserted into a nerve tube, into which the nerve is inserted.

Abstract: A media-playback device acquires a heart rate, selects a song with a first tempo, and initiates playback of the song. The song meets a set of qualification criteria and the first tempo is based on the heart rate, such as being equal to or less than the heart rate. The media-playback device also initiates playback of a binaural beat at a first frequency. Over a period of time, the binaural beat's first frequency is changed to a second frequency. Over the period of time, the first tempo can also be changed to a second tempo, where the second tempo is slower than the first tempo.

Abstract: Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: stimulation means for electrically stimulating at least one nerve with at least one stimulation pulse; control means connected to the stimulation means for controlling at least one characteristic of the at least one stimulation pulse; and modulating means connected to the control means for modulating the at least one characteristic of the at least one stimulation pulse according to the time of day.

Abstract: The present disclosure generally relates to extraforaminal electrical stimulation systems and leads for electrical stimulation of the dorsal root and dorsal root ganglion (DRG), minimally invasive implantation methods therefore, and related methods of providing extraforaminal electrical stimulation of the dorsal root and DRG for the treatment of a medical condition. In accordance with certain aspects, the extraforaminal electrical stimulation leads and methods are particularly suited for stimulation of dorsal roots and DRG of the cervical and thoracic spine.

Abstract: A lead having proximal and distal ends. At the distal end, a first branch includes a first biasing member and a first insulation covering. The first biasing member is disposed within the first insulation covering, which in turn includes a first inner surface. At the distal end, a second branch includes a second biasing member and a second insulation covering. The second biasing member is disposed within the second insulation covering, which in turn includes a second inner surface. The branches define a receiving channel and a stimulation region. The biasing members are movable away from each other to receive a target anatomy through the receiving channel and biasly movable toward each other to retain the target anatomy within the stimulation region. An electrode is disposed on one or both of the inner surfaces adjacent to the stimulation region, and is operable to stimulate the target anatomy.

Abstract: Some computer-assisted methods include: presenting configuration options to a user of the implanted stimulator device, the configuration options comprising stimulation parameters for the implanted stimulator; receiving a user specification of the configuration options in response to the presented configuration options; receiving user feedback when the user specified configuration options are implemented at the implanted stimulator device, the user feedback comprising a quantitative index of pain resulting from implementing the user specified configuration options on the implanted stimulator device; building a user profile for the user based on the user specified configuration options and the user feedback, the user profile including the user specified configuration options as well as the corresponding quantitative index of pain; and selecting at least one configuration option based on the user profile when the configuration options are subsequently presented to the user for a later treatment.

Abstract: An electric stimulator for brain, heart, skin and internal organs in animals and plants where the electrodes are distributed on a supporting structure. The supporting structure may be adapted for brain, heart, skin or other internal organs, as for DBS, heart pacemaker, TENS, etc. The invention discloses a plurality of electrodes at the surface of the supporting structure, from which electrically stimulating currents can be injected into the organism. Turning off an electrode while turning on another electrode has the effect of moving the stimulation within the body of the organism from one point to another point, with the same effect but with less spent energy than physically moving the whole electrode support. We call this electrode shifting. Rotational and translational electrode shifting are possible. The invention also discloses random changes of the electrode shifting, and random changes of the stimulation time and of the stimulation duration.

Abstract: The present invention relates to a formulation comprising an opioid, a Na channel blocker, an alpha2-receptor agonist, an opioid mu or delta receptor competitive antagonist and an intravenous anesthetic and/or a neurologic acting agent for use in pain control and/or cognitive function improvement.

Abstract: An example of a system may include electrodes on at least one lead configured to be operationally positioned for use in modulating neural tissue. The neural tissue may include at least one of dorsal horn tissue, dorsal root tissue or dorsal column tissue. The system may include an implantable device including a neural modulation device and a controller. The neural modulation device may be configured to use at least some of the electrodes to generate a modulation field to deliver sub-perception modulation to the neural tissue. The sub-perception modulation may have an intensity below a patient-perception threshold. The patient-perception threshold may be a boundary below which a patient does not sense generation of the modulation field. The controller may be configured to control the neural modulation device to generate the modulation field, and automatically adjust the modulation field in response to a patient input.

Abstract: The present invention relates to a wearable band for low frequency therapy and, more specifically, to a wearable band for low frequency therapy, the wearable band enabling a wearer to connect to a low frequency therapy device while wearing, on a body part, a cylindrical wearable band in which knitted pile yarn is formed from conductive fiber, thereby providing low-frequency stimulation to the part of the wearer's body such that the wearer can receive physical therapy.

Abstract: A system includes a head-mounted device to be worn by a person; a content generator driving the head-mounted device to engage the person to keep the person still in a predetermined position with sexually explicit visualization for the patient and sensors to detect a body position of the person and if the person have moved the body position, the sensors notify the content generator to encourage the person to move back into the predetermined position.

Abstract: A disposable electrical stimulation device and method for providing therapeutic treatment and pain management in a convenient, compact configuration. Electrode size and shape and relative configuration can be varied according to an intended application and use, or a universal configuration can be provided for use on almost any area of the body. The common structure of communicatively coupled dual electrodes including control circuitry and a power source accommodates a range of different sizes, configurations, stimulation treatment intensities, and other physical and electrical characteristics that can be pre-customized and packaged for specific, limited time use. The device can therefore be used in methods of providing therapy, managing pain, and achieving other treatment goals by electrical stimulation.

Abstract: An example of a system may include an arrangement of electrodes configured to be operationally positioned for use in modulating targeted neural tissue, a neural modulator, a communication module, and a controller. The neural modulator may be configured to use at least some electrodes within the arrangement of electrodes to generate a modulation field. The communication module may be configured to receive user-provided selections. The controller may be configured to use the communication module to receive a user-provided selection of a desired electrode list where the electrode list identifies electrodes within the arrangement of electrodes that are available for use in modulating the targeted neural tissue, control the neural stimulation modulator to generate the modulation field, and use the electrodes identified in the electrode list to modulate the targeted neural tissue.

Abstract: A multi-purpose wearable patch includes a stretchable and permeable substrate, a first sensing unit mounted in the stretchable and permeable substrate, the sensing unit that can conduct a first measurement of a user to produce a first measurement signal, a treatment unit that produces a first treatment field in the user's body; a circuit electrically connected with the treatment unit and the sensing unit; and a semiconductor chip in connection with the circuit and configured to receive the first measurement signal from the sensing unit. The semiconductor chip produces a first treatment control signal to control the treatment unit to produce a first treatment field in the user's body.

Abstract: Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.

Abstract: An example of a system for delivering neurostimulation may include a display and an interface control circuit. The interface control circuit may be configured to define a stimulation waveform according to which the neurostimulation is delivered. The stimulation waveform is defined by waveform parameters including one or more user-adjustable parameters. The interface control circuit may include a parameter selector, an effect analyzer, and a parameter generator. The parameter selector may be configured to present values for each user-adjustable parameter on the display and allow the user to select a value for each user-adjustable parameter from the presented values. The effect analyzer may be configured to estimate an interactive effect of different stimuli of the neurostimulation. The parameter generator may be configured to select a rate rule based on the estimated interactive effect and to generate the values for each user-adjustable parameter according to the selected rate rule.

Abstract: The invention relates to a drive mechanism (9) for a needle insertion arrangement (1), the drive mechanism (9) comprising an actuator (5) coupled to a parallel linkage (10) adapted to convert a linear movement of the actuator (5) in a longitudinal direction (L) to a linear movement of a cross beam (7) in transverse direction (T) substantially at right angles with respect to the longitudinal direction (L).

Abstract: Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: a housing; stimulation means for electrically stimulating at least one nerve; an electrode releasably mounted to the housing and connectable to the stimulation means for electrical stimulation of the at least one nerve; monitoring means for monitoring the user's body orientation and movement; analysis means for analyzing said orientation and movement; and control means for controlling the output of the stimulation means in response to said analysis of said orientation and movement.

Abstract: System and methods are provided for determining a stimulation threshold for closed loop spinal cord stimulation (SCS). The system and methods provide a lead coupled to an implantable pulse generator (IPG). The system and methods deliver SCS pulses from the IPG to the lead electrodes in accordance with an SCS therapy, and determine an evoked compound action potential (ECAP) amplitude based on an ECAP waveform resulting from the SCS therapy. The system and methods increase the SCS therapy by increasing at least one of an amplitude, a duration, and number of the SCS pulses associated with the SCS therapy. The system and methods also include iteratively repeat the delivering, determining and increasing operations until the ECAP amplitude exhibits a downward trend divergence. The system and methods define a stimulation threshold based on the ECAP amplitude at the trend divergence.

Abstract: Systems and methods for detecting intrathecal penetration are disclosed. A method in accordance with one embodiment includes detecting a value corresponding to an impedance of an electrical circuit that in turn includes an electrical contact located within the patient, and patient tissue adjacent to the electrical contact. The method further includes comparing the detected value to a predetermined criterion, and, if the detected value meets the predetermined criterion, identifying penetration of the patient's dura based at least in part on the detected value.

Abstract: Electrical neurostimulation leads for use in craniofacial peripheral nerve neurostimulation (e.g. occipital neurostimulation). Paddle leads, lead wires, lead wire anchors, tools, or other hardware can be designed for implantation in the craniofacial region. This can address problems of electrical neurostimulation in the craniofacial region such as lead migration, hardware breakage, patient discomfort, or other problems.

Abstract: Extended pain relief via high frequency spinal cord modulation, and associated systems and methods. A method for treating a patient in accordance with a particular embodiment includes selecting a neural modulation site to include at least one of a dorsal root entry zone and dorsal horn of the patient's spinal cord, and selecting parameters of a neural modulation signal to reduce patient pain for a period of time after ceasing delivery of the signals, the period of time being at least one tenth of one second.

Abstract: In a high voltage, variable frequency radiation generation system, a carrier signal supplied to a primary coil of a transformer is varied, e.g., turned ON and OFF at variable frequencies. The ON duration and/or the average amplitude of the carrier signal may also be varied. Moreover, the carrier signal may be modulated using an audio signal. The parameters to control the variation of the carrier can be provided as a recipe via a software application. A server can provide different types of apps providing different control features. The server may also collect user characteristic data and recipe usage data, and may facilitate exchange of these data and may recommend recipes based on a particular user characteristic.

Abstract: An example of a system for programming a neurostimulator may include a storage device and a pattern generator. The storage device may store a pattern library and one or more neuronal network models. The pattern library may include fields and waveforms of neuromodulation. The one or more neuronal network models may each be configured to allow for evaluating effects of one or more fields in combination with one or more waveforms in treating one or more indications for neuromodulation. The one or more neuronal network models may include a first pain model configured to allow for optimization of neurostimulation using paresthesia, the second pain model configured to allow optimization of neurostimulation using anatomy. The pattern generator may be configured to construct and approximately optimize a spatio-temporal pattern of neurostimulation and/or its building blocks using at least one or more of the first pain model or the second pain model.

Abstract: Wearable devices for Noxipoints stimulation have a wearable member containing a grid of electrodes. The device is configured by a computer software to identify at least a pair of Noxipoints for applying one or more voltages to stimulate the Noxipoints.

Abstract: An implantable pulse generator (IPG) that generates spinal cord stimulation signals for a human body has a programmable signal generator that can generate the signals based on stored signal parameters without any intervention from a processor that controls the overall operation of the IPG. While the signal generator is generating the signals the processor can be in a standby mode to substantially save battery power.

Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, a programmer has instructions that, in response to an input, select between a paresthesia-inducing therapy program that includes a frequency of less than 1,500 Hz, and a non-paresthesia-inducing therapy program that includes a frequency in range from 1.5 kHz to 50 kHz.

Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, a programmer has instructions that, in response to an input, select between a paresthesia-inducing electrical therapy signal having a frequency of less than 1.2 kHz, and a non-paresthesia-inducing electrical therapy signal having a frequency in a range from 1.5 kHz to 100 kHz.

Abstract: An acupuncture device can include a frame, an enclosure disposed on the frame to protect the frame, multiple stimulators mounted on the frame. The stimulators can be electrically coupled with a controller that transmits electric pulses to the stimulators for electro-acupuncture purpose. The size of the frame is adjustable to fit different body sizes of the users. The stimulators can be carried by the adjustment of the frame. The acupuncture device can also include one or more position references and the stimulators are positioned at relative distances from the position references. When the size of the frame is adjusted, the stimulators are carried by the frame to new positions that are at relative distances from the position references in proportionality with the extent of adjustment of the frame. Hence, the relative distance between a stimulator and a position reference in light of the size of the frame is maintained.

Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, a programmer has a computer-readable medium containing executable instructions in memory to, in response to an input, select between at least two therapy programs: a first having a frequency of less than 1,500 Hz, and a paresthesia-inducing amplitude between 3 mA and 10 mA; and a second having a frequency between 5 kHz and 15 kHz, and a non-paresthesia-inducing amplitude between 0.5 mA and 10 mA.