Abstract: A syringe set includes a syringe and a heating device. The heating device includes a heating module in thermal engagement with the syringe and a body supporting the heating module. The heating module includes a first electrode, a second electrode and a heating element. The heating element includes a plurality of carbon nanotubes forming at least one electrically conductive path. The first electrode and the second electrode electrically connect with the carbon nanotubes.

Abstract: Surgical systems, devices and methods including one or more tissue stimulation elements that, in some instances, may also be used for sensing purposes. Some of the surgical devices also include a tissue coagulation element.

Abstract: Skin tissue is subjected to thermal energy that creates heating of the area being treated causing pores and follicle ducts to open so that excess oil, sebum, fatty deposits, or other unwanted deposits can be removed. A vacuum device is used to direct suction to the treated skin area helping to remove the unwanted deposits. Patterned thermal modification of tissue is used to expedite healing and minimize pain. The heating is controlled so that no skin tissue is damaged while still providing enough heat to the skin to alter the flow of sebum and destroy bacteria in the treated area.

Abstract: An auxiliary mat for a hyperthermo-therapeutic apparatus, a hyperthermo-therapeutic apparatus including the same, and a method of using the hyperthermo-therapeutic apparatus are provided. In a hyperthermo-therapeutic apparatus including a main mat and an auxiliary mat, a receiving groove is formed at a side of the main mat or the auxiliary mat, and an external hyperthermo-therapeutic unit is detachably mounted in the receiving groove. In a state where a user sits astraddle on the main mat or the auxiliary mat, the external hyperthermo-therapeutic unit is operated so that a hot compress effect or an effect generated by radiating far infrared rays can be simply obtained on a lower part of a user's body. Upon use of the hyperthermo-therapeutic apparatus, there are advantages in that the user does not need to take an uncomfortable posture for receiving a hot compress on the lower part of her/his body.

Abstract: A radio frequency diathermy application device, including a flexible pad and a flexible coil structure coupled to and supported by the pad The flexible coil structure has a flexible spiral-like primary winding and a flexible spiral-like secondary winding coupled to the primary winding, the primary and secondary windings each substantially lying in separate substantially parallel planes when the pad is in an unflexed state.

Abstract: Disclosed are a method for bending a self-regulating cable having a function of maintaining a predetermined temperature by applied electric power, in which the self-regulating cable is arranged in zigzags by easily bending the self-regulating cable, and a heating mat for preventing overheating using the same. A heating mat comprises: a heat generating means for maintaining a predetermined temperature with applied electric power; a control unit electrically connected to the heat generating means, for regulating the electric power supplied to the heat generating means; and an exterior material surrounding the heat generating means. The method comprises: setting a bent portion of the self-regulating cable; exposing the semi-conductive polymer by removing a portion of the insulation film, which corresponds to the bent portion; exposing a pair of wires by removing the exposed semi-conductor polymer; and bending portion of the pair of wires, which correspond to the exposed bent portion.

Abstract: The present invention provides an apparatus and a method for generating and applying an electric field according to a user configured arbitrary waveform pulsing train. A control module allows the user to input operation parameters and configure the arbitrary waveform pulsing train for the electroporation process. A micro-controller unit coupled to the control module controls an arbitrary waveform generator unit and a customized power module. During the electroporation process, the arbitrary waveform generator unit produces the arbitrary waveform pulsing train that is amplified by the customized power module. The customized power module is coupled to at least two electrodes, wherein the at least two electrodes will produce an electric field across a target media.

Abstract: This invention relates to a heating device for low voltage thermal therapy in which a heating layer is provided on the protector body and a lead wire is extended from the heating layer, a terminal being provided on the lead wire which is connected with the terminal of a thermostat. With this structure, low voltage direct current is supplied to the heating layer for generating heat required and temperature is regulated by the thermostat such that restoration effect on the injury condition of affected part is further enhanced.

Abstract: This relates to methods and devices for achieving contact between the wall of a cavity or passageway and a medical device under conditions in which an access path and the subject anatomy are not aligned.

Abstract: An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.

Abstract: An apparatus and method for the dissociation of soft proteinaceous tissue using pulsed rapid variable direction energy field flow fractionization is disclosed. The pulsed rapid disruptive energy field is created by the use of a probe which surrounds the soft proteinaceous tissue to be removed. Once the adhesive mechanism between tissue constituents has been compromised, fluidic techniques are used to remove the dissociated tissue.

Abstract: A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C.

Abstract: The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

Abstract: Devices and methods for the treatment of skin conditions and lesions are disclosed herein. One aspect of the invention is a compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices described herein employ the application of heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 70° C. to about 400° C. by the devices, are achieved in less than about 1 second, and maintained for less than about 1 second. In some embodiments, the skin surface is heated with heat pulses. Thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.

Abstract: A refrigerant-containing bladder or container is positioned underneath the body. Heat absorbed from the body vaporizes the refrigerant, which expands to cooler remote regions of the bladder. Heat is then withdrawn from the edges of the container by thermally conductive pathways that distribute heat from this container to a cooler area that is not underneath the body. The cooled refrigerant condenses, and is returned to the regions of the device that are under or adjacent to the central and warmest parts of the body. The heavier and warmer portions of the body force the bladder to the lowest point. Alternatively, heat is transferred from the body via a specific highly thermally conductive layer or layers of material(s) that is (are) soft, pliable, and comfortable to sit or lie on. This layer joins conductive materials that are configured to transport heat and diffuse it to the cooler environment.

Abstract: A radiant therapeutic wrist heating pad, which is not hot to the touch, provides substantial infrared radiation to a user's wrist to alleviate symptoms of carpal tunnel syndrome. It can be used for extended periods without feeling uncomfortable to the skin, while imparting deep therapeutic heat to the user's wrist. The heating pad is comprised of a radiant heat generating layer having a plane surface comprising means for radiating heat evenly from its surface, a pair of flexible electrically insulating and radiation permeable layers located adjacent and covering opposite sides of the layer, a thermal insulation layer disposed against and covering one of the electrically insulating layers, and a sealed radiation permeable envelope enclosing the entire heater.

Abstract: A medical warming system includes a plurality of heating elements respectively adapted to be disposed closed to various parts of a plurality of patients' bodies, a first group of sensors disposed at the proximity of the heating elements and configured for measuring the temperatures of the heating elements, a second group of sensors adapted to be disposed at the various parts of the patients' bodies and configured for measuring the temperatures of the various parts of the patients' bodies, and a controller being in communication with the first group and the second group of sensors. The controller is configured for receiving temperature data from the sensors and controlling the temperature of each heating element accordingly. Each heating element includes a conductive layer made from a nano-thickness material.

Abstract: A device for generating atmospheric pressure cold plasma inside a hand-held unit discharges cold plasma with simultaneously different rf wavelengths and their harmonics. The device includes an rf tuning network that is powered by a low-voltage power supply connected to a series of high-voltage coils and capacitors. The rf energy signal is transferred to a primary containment chamber and dispersed through an electrode plate network of various sizes and thicknesses to create multiple frequencies. Helium gas is introduced into the first primary containment chamber, where electron separation is initiated. The energized gas flows into a secondary magnetic compression chamber, where a balanced frequency network grid with capacitance creates the final electron separation, which is inverted magnetically and exits through an orifice with a nozzle. The cold plasma thus generated has been shown to be capable of accelerating a healing process in flesh wounds on animal laboratory specimens.

Abstract: Disclosed is a method and an apparatus for ablating biological tissues, in which a cannula is configured to affect biological tissue and a heat transmitting end-effecter is coupled to the cannula. A source of electromagnetic energy is provided via an electro-magnetic energy emitter and a wall of the heat transmitting end-effecter is made of an electromagnetic-energy-absorbing material that absorbs electromagnetic waves.

Abstract: The present invention is directed to a body temperature controlling system comprising at least one member receiving a flow of gas from at least one blower in communication with said at least one member, said at least one member directing said flow of gas onto a wearer thereof.

Abstract: A system and method are presented for treating branches of the superior hemorrhoidal artery by photocoagulation using laser energy. The inflamed dilated blood vessels in and around the anal region, often called hemorrhoids or piles, are caused due to a connective tissue disorder, a relative increase in pressure in the superior hemorrhoidal artery and a weakening of the vessels' valves. A suitable treatment system and a method are given for treating such conditions in a minimally invasive manner. The treatment system photocoagulates the branches of a superior hemorrhoidal artery in the anal and rectal regions using laser energy while causing minimal pain or discomfort to the patient. The system is provided with a transparent operational window. The distal end of the fiber and Doppler system channel are at the operational window. The system also includes a viewing window. The post operative recovery is faster than alternative approaches with no complications.

Abstract: A radiant therapeutic heating apparatus may include a radiant heat generating layer having a plane surface including an infrared radiator adapted to radiate heat evenly from its surface, a pair of flexible electrically insulating and radiation-permeable layers located adjacent and covering opposite sides of the layer, a thermal insulation layer disposed against and covering one of the electrically insulating layers, and a sealed radiation permeable envelope enclosing the heating apparatus. The flexible heat generating layer may include a fiberglass material impregnated with a resistive material, which material may provide a surface temperature, when current is conducted therethrough, of no greater than about 54 degrees Celsius. Current limiting thermostats may be provided to prevent energy and temperature spikes. A stiffening element may help protect the components, and may orient portions of a user's body (such as, e.g., but not limited to, the wrist for repetitive strain injuries) in a therapeutic position.

Abstract: A climate control pad includes a pad body having a climate treating surface and an air circulating circuit formed thereon for preserving a volume of air within the air circulating circuit in a circulating manner, and a heat generating element, which is a fiber heating wire, disposed in the air circulating circuit for generating heat to increase the temperature of the air within the air circulating circuit so as to evenly distribute the heat from the heat generating element on the climate treating surface of the pad body. In addition, the pad body is adapted to incorporate with a cooling source to provide a cooling air towards the climate treating surface of the pad body.

Abstract: Improved corrective procedures for conductive keratoplasty are disclosed. Over correction can be relieved by the addition of one or two spots along one of the rings on the cornea.

Abstract: A radio-electric conveyer includes one or more radiofrequency generators supplied by a power group; one or more irradiating antennas coupled with the generator and which are able to create a radiofrequency field; a variable modulator; and one or more electrodes connected to generator and able to be applied to one or more predetermined parts of a body object of the therapy treatment, placed inside the field, in order to convey radiofrequency currents to the body.

Abstract: Methods, devices, and systems for treating the support structures of the body, particularly for incontinence, take advantage of two mechanisms to enhance the support provided by the fascia, ligaments and tendons: first, the invention increases a modulus of elasticity of these tissues, and particularly of the fascial tissues. The increase in modulus can be effected by directing sufficient energy to the fascial tissue so as to promote the formation of scar tissue. The second mechanism attaches tissue planes together, often by directing energy to an interface between adjacent fascial tissues.

Abstract: A skin-contacting heatable dressing including a pressure-sensitive adhesive layer having a first skin-contacting side and a second side; heat generating conductive carbon fibers contained within the skin-contacting pressure sensitive adhesive layer; and a source of electrical energy electrically connected to the carbon fibers. In one embodiment, the pressure-sensitive adhesive layer may include a transdermally absorbable medicament. In one embodiment, the dressing may include a backing layer. In one embodiment, the source of electrical energy may be a thin film battery, which may supplement or take the place of the backing layer.

Abstract: An endoscopic forceps for treating tissue includes a handle assembly having a elongated shaft extending therefrom which is movable relative to the handle assembly by an actuator. The forceps also including an end effector assembly attached to a distal end of the shaft which has first and second jaw members which are movable about a pivot from a first position in spaced relation relative to one another to a second position for clamping tissue. Each of the jaw members include: an insulative outer housing having an electrically conductive, inwardly facing tissue contacting surface and a proximal flange with a camming surface. The proximal flange being provided with a spring-like tail which mounts within the distal end of the elongated shaft to bias the jaw members in an open configuration. The actuator is movable relative to the handle to actuate the elongated shaft to cam the proximal flanges to pivot the jaw members toward the second position to clamp tissue.

Abstract: A high frequency electrosurgical power generator configured to produce electrical power at a frequency of about 1 to about 14 MHz and preferably having an essentially sinusoidal waveform with a voltage level up to 1,000 Vrms, and a current level up to 5 Amps. The output of the high frequency electrosurgical power generator is connected to an electrosurgical tool configured to receive the voltage and current produced by the electrosurgical power generator and deliver the voltage and current to an electrosurgical site. The output of the electrosurgical generator preferably is an essentially sinusoid waveform with a frequency between about 3 MHz and about 8 MHz, up to about 700 volts rms, up to about 2 amps, with a total power of up to 1,000 watts.

Abstract: Methods and devices for the treatment of skin lesions resulting from bacterial, fungal or viral infections or from exposure to irritants are disclosed. The invention relates methods and devices for delivering a controlled dose of thermal energy to the infected or irritated tissue and thereby speed the recovery process.

Abstract: The present invention relates to methods for treating inflammation in body tissues. More specifically, certain disclosed methods relate to selectively inducing apoptosis in inflammatory immune cells. The methods are particularly suitable for treating inflamed atherosclerotic plaques. The techniques generally involve heating the cells with a catheter that is equipped to produce infrared radiation. The cells are heated for a sufficient time and at a sufficient temperature to induce programmed cell death.

Abstract: A method of achieving tissue changes in bone or bone-derived organic tissue, in which method bone or bone-derived organic tissue is provided, an interfacing agent is applied to the bone or bone-derived organic tissue, and electromagnetic energy is applied to the interfacing agent. The interfacing agent can include collagen, preferably bone-derived collagen, and a therapeutic agent. In a related embodiment, a method of treating bone tissue is provided wherein a bioactive interfacing agent is placed between the bone segments of the bone tissue to be treated.

Abstract: Delivery elements, including needle electrodes and sheaths of tissue ablation devices, containing a conductivity-enhancing agent are discussed. The delivery elements contain a body member and optionally one or more coating layers. The conductivity-enhancing agent is disposed on or in the body member and/or at least one of the one or more coating layers. The conductivity-enhancing agent is capable of eluting from the delivery element when the delivery element is contacted with bodily tissue or fluid and increases conductivity of the tissue, making tissue ablation more efficient.

Abstract: A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction.

Abstract: A forced air warming unit has a casing with inlet and outlet openings. The casing encloses a scroll housing with a curved inside surface in which a blower is disposed. A circuit board in the casing encloses the blower in the scroll housing. At least one opening penetrates the circuit board. A heater plate is disposed between the circuit board and the blower. The blower draws air through the inlet opening, along a first side of the circuit board through the at least one opening into the scroll housing. The blower also forces air along a second side of the circuit board which faces the scroll housing, through air passages in the circuit board, along the first side through the at least one opening, into the scroll housing. The blower accelerates air along the curved inside surface and past the heater plate. Heated, pressurized air exits through the outlet opening.

Abstract: A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C.

Abstract: The present invention provides a bed type hot compress and acupressure apparatus using a means for controlling a location of a hyperthermo-radiative device wherein a moving location of the hyperthermo-radiative device can be controlled based on an actually moved distance of the hyperthermo-radiative device.

Abstract: A self-heating, portable massage or therapy table is disclosed. The portable massage table comprises a cushioned pad that is comfortable for a user to sit or lie on. Preferably inside the cushioned pad is an electrical heat mechanism which heats the cushioned pad. The cushioned pad and the heat mechanisms are sectioned so that the surface can be folded. Finally, the table comprises foldable legs that support the table.

Abstract: Disclosed is a bed for diagnosis which can block a water vein and an electromagnetic wave and generate an ultra-long wave. The bed prevents the influence of a water vein or an electromagnetic wave on a patient or a sleeper, and alleviates pains on various parts of the body by its function of thermotheraphy. In addition, the bed generates far-infrared and ultra-long waves to expedite the recovery of health.

Abstract: The present invention features an ultrasonic surgical system including an ultrasonically vibrating blade, and retractable grasper. The grasper includes a grasping jaw or clamp that is movable, in a direction perpendicular to the primary vibratory mode of the ultrasonic blade element, from an open, extended position to a closed position in which tissue is grasped between the jaw and the vibrating blade, and to a retracted position for storage. The jaw is preferably hinge-actuated.

Abstract: A forced air warming unit has a casing that encloses a scroll housing with a curved inside surface. A blower is disposed in the scroll housing inside the curved surface. Inlet and outlet openings are provided in the casing. A circuit board is mounted in the casing, against the scroll housing so that the blower is enclosed in space between the scroll housing and the circuit board. At least one opening is provided through the circuit board into the space in which the blower is disposed. A tapered, elongate, arcuate heater plate is disposed in the scroll housing between the circuit board and the blower, with a relatively wide end near the outlet opening and a second, relatively narrower end near the curved inside surface. Air is conducted in response to operation of the blower through the inlet opening, along a first side of the circuit board through the one or more openings in the circuit board into the scroll housing.

Abstract: In general, the invention provides a transurethral ablation device comprising an electrode for delivery of neurostimulation therapy to a patient to prevent or alleviate pain experienced during the course of a transurethral ablation procedure. The device may include a conductive ablation needle that delivers electrical current for ablation of prostate tissue, as well as neurostimulation current to prevent or alleviate pain encountered in response to the ablation current. In this sense, the ablation needle is integrated with a neurostimulation electrode. Alternatively, the device may incorporate a dedicated neurostimulation electrode independently of the ablation needle, either on the needle or on a catheter body that carries the needle.

Abstract: The invention relates to an electrosurgical tool which includes in a housing an active and return electrode which can be controlled in use so that it is the active electrode which performs the electrosurgical function in contact with the body tissue. The tool may be controlled with the return electrode in contact with the body tissue but preferably not in contact with the body tissue. The return electrode is typically formed from a number of components spaced with respect to the active electrode.

Abstract: Methods, devices, and systems for treating the support structures of the body, particularly for incontinence, take advantage of two mechanisms to enhance the support provided by the fascia, ligaments and tendons: first, the invention increases a modulus of elasticity of these tissues, and particularly of the fascial tissues. The increase in modulus can be effected by directing sufficient energy to the fascial tissue so as to promote the formation of scar tissue. The second mechanism attaches tissue planes together, often by directing energy to an interface between adjacent fascial tissues.

Abstract: The Flash Technique is a new concept in thermodynamics. This technique of accumulating heat energy in a small air plenum being instantaneously flashed over the problem region of the body in a thermowave manner is capable of accomplishing with high efficiency and simultaneously Thermotherapy, Immunetherapy and Chemotherapy treatments in the patients' own home. The term “problem region” refers to tumors, a set of muscles, or any other site causing difficulty and which lends to the use of instantaneous high temperature air pulse flashes. The low power and the small size and weight of this home unit lend to the use of a flexible belt to support two applicators against different parts the body.

Abstract: A method for treating cancerous or benign conditions of a body or organ employs selective irradiation of the body tissue with energy. The method includes the steps of monitoring temperatures of the skin surface adjacent the body, positioning at least one energy applicator around the body, delivering energy to the at least one energy applicator to selectively irradiate the body tissue with energy and treat at least one of cancerous and benign conditions of the body, adjusting the level of power to be delivered to the at least one energy applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the at least one energy applicator, determining total energy delivered to the at least one energy applicator, and completing the treatment when the desired total energy dose has been delivered by the at least one energy applicator to the body.

Abstract: A heating pad assembly includes a cover member designed for abutting the back of a user. The cover member defines an interior space. A heating assembly is positioned within the cover member. The heating assembly has a first portion and a second portion. The first portion is positioned on a first side of the interior space. The second portion is positioned on a second side of the interior space. The first and second portions are positioned such that a center column through the interior space does not have either the first or second portions of the heating assembly positioned therein. A cord assembly is operationally coupled to the heating assembly. The cord assembly is designed for coupling to a conventional household electrical outlet. The cord assembly facilitates flow of electrical current through the heating assembly.

Abstract: A device for monitoring temperature generated by an ablation apparatus on organic tissue is provided. The device comprises a temperature sensing pad; and an output device to receive and display a representation of a lesion found on the ablated organic tissue. Ablation systems incorporating the device and methods of using the device are also provided.

Abstract: A technique and apparatus therefor adapted to treat in situ specified tissue, especially a malignant tumor, use being made of electrodes implanted in the tissue at spaced positions. Applied across the electrodes is a voltage causing a current to flow through the tissue to be treated. This current in one embodiment of the invention produces an electrochemical reaction yielding multiple reaction products, some of which are cytotoxic agents destructive of cancer cells, the voltage being regulated to optimize the yield of those agents having the greatest efficacy. In another embodiment, fed to the tissue is one or more reagents which when current flows through the tissue react with the material of an electrode to yield a cytotoxic agent in situ. Alternatively, the surface of the electrode can serve as a catalyst for the formation of the cytotoxic agents.

Abstract: A method for treating cancerous or benign conditions of an organ includes the steps of inserting an E-field probe sensor to a depth in the organ tissue, monitoring temperatures of the skin surface adjacent the organ, positioning two or more energy applicators around the organ, setting the initial relative phase delivered to each energy applicator to focus the energy at the E-field probe positioned in the organ tissue, delivering energy to the applicators to selectively irradiate the organ tissue, adjusting the power level to be delivered to each applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the applicators, determining total energy delivered to the applicators and displaying the total energy in real time during the treatment, and completing the treatment when the desired total energy dose has been delivered by the energy applicators to the organ. Either focused or non-focused may be employed.