Including Bio-absorbable Material Patents (Class 623/13.18)
  • Patent number: 6458148
    Abstract: A strand-like implant of resorbable polymer material is substantially formed as a random copolymer of L-lactide and glycolide, which are present in a composition in a range of more than 80 mole % lactide and less than 20 mole % glycolide to 95 mole % lactide and 5 mole % glycolide, particularly in a ratio of 90:10, and has in the textile structure a tensile strength of more than 200 N/mm2.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: October 1, 2002
    Assignee: Aesculag AG & Co. KG
    Inventors: Martin Dauner, Helmut Goldmann, Helmut Hierlemann, Heinrich Planck
  • Publication number: 20020062152
    Abstract: A medical, bioresorbable implant, particularly for crucial ligament augmentation, is constructed as a composite structure in textile construction from at least two biocompatible polymer materials, which differ in their chemical composition and/or polymer structure and which are degradable, the implant having a predetermined initial tensile stiffness and a different degradation behaviour of the polymers and/or the textile construction is selected in such a way that the tensile stiffness decreases during degradation.
    Type: Application
    Filed: September 12, 2001
    Publication date: May 23, 2002
    Inventors: Martin Dauner, Helmut Hierlemann, Heinrich Planck, Lutz Claes, Lutz Duerselen, Anita Ignatius
  • Patent number: 6378527
    Abstract: Cells grown on a microcarrier are separated from the microcarrier by enzymatically digesting the microcarrier. More specifically, chondrocytes may be grown on dextran microcarrier beadlets and then the beadlets digested using dextranase to separate the chondrocytes from the carrier. Cells can also be grown on chitosan microcarriers to be used for implantation. In addition, cells can be grown on polysaccharide polymers to be used as implant devices. Various polymers serve as scaffolds for cells to be used for implantation. The polymers can be used for cell culture as well as for preparing scaffolds useful for tissue replacement such as cartilage tissue.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: April 30, 2002
    Assignee: Chondros, Inc.
    Inventors: David S. Hungerford, Carmelita G. Frondoza, Afshin Sohrabi, Alan H. Shikani, Abraham J. Domb
  • Patent number: 6365149
    Abstract: The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: April 2, 2002
    Assignee: Ethicon, Inc.
    Inventors: Murty N. Vyakarnam, Mark C. Zimmerman, Angelo George Scopelianos, Mark B. Roller, David V. Gorky
  • Publication number: 20020022883
    Abstract: The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or absorbable three-dimensional support construct, a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered to an area of interest in a living subject. The biodegradable construct provides an ideal surface for cell or cell extract attachment, while the gel matrix or viscous fluid acts as both a carrier material and a separator for maintaining the space between the constructs as well as the structural integrity of the developing issue.
    Type: Application
    Filed: June 12, 2001
    Publication date: February 21, 2002
    Inventor: Karen J.L. Burg
  • Patent number: 6210441
    Abstract: Linear block polymer having a molecular weight of at least 104 Dalton, comprising urea and urethane groups and ester groups at such a distance from each other that after hydrolysis of these ester groups fragments are created which are so small that they are biologically degradable and can be excreted from a human body and further including an end group selected from primary NH2 and OH groups, which can be substituted by a monoamine. The polymers are intended to be used as implants.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: April 3, 2001
    Assignee: Artimplant Development Artdev AB
    Inventor: Per Flodin